array:22 [
  "pii" => "S2666275224001164"
  "issn" => "26662752"
  "doi" => "10.1016/j.abdp.2024.05.007"
  "estado" => "S300"
  "fechaPublicacion" => "2024-09-01"
  "aid" => "956"
  "copyrightAnyo" => "2024"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:17 [
      "pii" => "S0365059624000977"
      "issn" => "03650596"
      "doi" => "10.1016/j.abd.2023.08.016"
      "estado" => "S300"
      "fechaPublicacion" => "2024-09-01"
      "aid" => "956"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:9 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Letter - Research</span>"
        "titulo" => "Oral minoxidil 7&#46;5&#8239;mg for hair loss increases heart rate with no change in blood pressure in 24&#8239;h Holter and 24&#8239;h ambulatory blood pressure monitoring"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "734"
            "paginaFinal" => "736"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Baltazar Dias Sanabria, Yuri Chiarelli Perdomo, H&#233;lio Amante Miot, Paulo M&#252;ller Ramos"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Baltazar Dias"
                "apellidos" => "Sanabria"
              ]
              1 => array:2 [
                "nombre" => "Yuri Chiarelli"
                "apellidos" => "Perdomo"
              ]
              2 => array:2 [
                "nombre" => "H&#233;lio Amante"
                "apellidos" => "Miot"
              ]
              3 => array:2 [
                "nombre" => "Paulo M&#252;ller"
                "apellidos" => "Ramos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "pt" => array:9 [
          "pii" => "S2666275224001164"
          "doi" => "10.1016/j.abdp.2024.05.007"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "pt"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224001164?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000977?idApp=UINPBA00008Z"
      "url" => "/03650596/0000009900000005/v2_202409130645/S0365059624000977/v2_202409130645/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "S2666275224001152"
    "issn" => "26662752"
    "doi" => "10.1016/j.abdp.2024.05.006"
    "estado" => "S300"
    "fechaPublicacion" => "2024-09-01"
    "aid" => "955"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "pt" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Cartas &#8208; Investiga&#231;&#227;o</span>"
      "titulo" => "Uso de imunoglobulina intravenosa como terapia de resgaste da neurite parainfecciosa hans&#234;nica refrat&#225;ria&#58; s&#233;rie de casos"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "736"
          "paginaFinal" => "739"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jo&#227;o Guilherme Pess&#244;a L&#233;o, Camila Bocchi Siqueira, Jorgeth de Oliveira Carneiro da Motta, Ingrid Faber de Vasconcellos, Yuna Ribeiro de Araujo, Felipe Von Glehn, Patr&#237;cia Shu Kurizky, Ciro Martins Gomes, Cl&#225;udia Porto, Maria Stella Cochrane Feitosa"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Jo&#227;o Guilherme Pess&#244;a"
              "apellidos" => "L&#233;o"
            ]
            1 => array:2 [
              "nombre" => "Camila Bocchi"
              "apellidos" => "Siqueira"
            ]
            2 => array:2 [
              "nombre" => "Jorgeth de Oliveira Carneiro da"
              "apellidos" => "Motta"
            ]
            3 => array:2 [
              "nombre" => "Ingrid Faber de"
              "apellidos" => "Vasconcellos"
            ]
            4 => array:2 [
              "nombre" => "Yuna Ribeiro de"
              "apellidos" => "Araujo"
            ]
            5 => array:2 [
              "nombre" => "Felipe Von"
              "apellidos" => "Glehn"
            ]
            6 => array:2 [
              "nombre" => "Patr&#237;cia Shu"
              "apellidos" => "Kurizky"
            ]
            7 => array:2 [
              "nombre" => "Ciro Martins"
              "apellidos" => "Gomes"
            ]
            8 => array:2 [
              "nombre" => "Cl&#225;udia"
              "apellidos" => "Porto"
            ]
            9 => array:2 [
              "nombre" => "Maria Stella Cochrane"
              "apellidos" => "Feitosa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0365059624000965"
        "doi" => "10.1016/j.abd.2023.09.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000965?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224001152?idApp=UINPBA00008Z"
    "url" => "/26662752/0000009900000005/v2_202409060549/S2666275224001152/v2_202409060549/pt/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2666275224001176"
    "issn" => "26662752"
    "doi" => "10.1016/j.abdp.2024.05.008"
    "estado" => "S300"
    "fechaPublicacion" => "2024-09-01"
    "aid" => "957"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "pt" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Cartas &#8208; Investiga&#231;&#227;o</span>"
      "titulo" => "A f&#237;stula arteriovenosa &#233; fator de risco para o carcinoma espinocelular&#63; Avalia&#231;&#227;o em servi&#231;o universit&#225;rio"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "730"
          "paginaFinal" => "734"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0025"
          "etiqueta" => "Figura 5"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr5.jpeg"
              "Alto" => 2376
              "Ancho" => 1675
              "Tamanyo" => 1005404
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Histologia do tumor da <a class="elsevierStyleCrossRef" href="#fig0020">figura 4</a> &#40;cortes em parafina&#44; Hematoxilina &#38; eosina&#46; &#40;A&#41; Neoplasia exof&#237;tica&#44; com superficializa&#231;&#227;o das papilas&#44; abundante material c&#243;rneo&#44; como as verrugas &#40;prov&#225;vel papel do HPV&#44; pela imunossupress&#227;o&#41;&#46; &#40;B&#41; N&#250;cleos at&#237;picos&#44; embora alguns se destaquem mais pelo grau de hipercromasia&#46; Presen&#231;a de mitoses at&#237;picas &#40;seta amarela&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ariany Tomaz de Aquino Saran Denofre, Thais Helena Buffo, Rafael Fantelli Stelini, Maria Leticia Cintra, Renata Ferreira Magalh&#227;es"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Ariany Tomaz de Aquino Saran"
              "apellidos" => "Denofre"
            ]
            1 => array:2 [
              "nombre" => "Thais Helena"
              "apellidos" => "Buffo"
            ]
            2 => array:2 [
              "nombre" => "Rafael Fantelli"
              "apellidos" => "Stelini"
            ]
            3 => array:2 [
              "nombre" => "Maria Leticia"
              "apellidos" => "Cintra"
            ]
            4 => array:2 [
              "nombre" => "Renata Ferreira"
              "apellidos" => "Magalh&#227;es"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0365059624000989"
        "doi" => "10.1016/j.abd.2023.07.015"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000989?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224001176?idApp=UINPBA00008Z"
    "url" => "/26662752/0000009900000005/v2_202409060549/S2666275224001176/v2_202409060549/pt/main.assets"
  ]
  "pt" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Cartas &#8208; Investiga&#231;&#227;o</span>"
    "titulo" => "Minoxidil 7&#44;5<span class="elsevierStyleHsp" style=""></span>mg oral para queda de cabelo aumenta a frequ&#234;ncia card&#237;aca sem altera&#231;&#227;o da press&#227;o arterial no Holter de 24<span class="elsevierStyleHsp" style=""></span>h e na monitoriza&#231;&#227;o ambulatorial da press&#227;o arterial de 24<span class="elsevierStyleHsp" style=""></span>h"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Prezado Editor&#44;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "734"
        "paginaFinal" => "736"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Baltazar Dias Sanabria, Yuri Chiarelli Perdomo, H&#233;lio Amante Miot, Paulo M&#252;ller Ramos"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "Baltazar Dias"
            "apellidos" => "Sanabria"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Yuri Chiarelli"
            "apellidos" => "Perdomo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "H&#233;lio Amante"
            "apellidos" => "Miot"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "Paulo M&#252;ller"
            "apellidos" => "Ramos"
            "email" => array:1 [
              0 => "dermato.paulo@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Universidade Federal do Mato Grosso do Sul&#44; Campo Grande&#44; MS&#44; Brasil"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Faculdade de Medicina de S&#227;o Jos&#233; do Rio Preto&#44; S&#227;o Jos&#233; do Rio Preto&#44; SP&#44; Brasil"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Infectologia&#44; Dermatologia&#44; Diagn&#243;stico por Imagem e Radioterapia&#44; Faculdade de Medicina&#44; Universidade Estadual Paulista&#44; Botucatu&#44; SP&#44; Brasil"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspond&#234;ncia&#46;"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">O minoxidil oral em baixa dose &#40;MOBD&#41; constitui alternativa importante para o tratamento de diferentes causas de queda de cabelo&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Entretanto&#44; seus efeitos adversos cardiovasculares&#44; como taquicardia&#44; hipotens&#227;o e edema&#44; continuam a ser uma preocupa&#231;&#227;o mesmo em doses baixas&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Em geral&#44; a dose padr&#227;o para o tratamento da hipertens&#227;o varia de 10 a 40<span class="elsevierStyleHsp" style=""></span>mg&#47;dia&#44; e n&#227;o h&#225; consenso sobre a dosagem ideal para o tratamento da queda de cabelo&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Uma ampla gama de doses &#40;de 0&#44;25 a 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia&#41; foi avaliada em estudos cl&#237;nicos&#44; sem exceder 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Recentemente&#44; uma metan&#225;lise demonstrou associa&#231;&#227;o positiva dose&#8208;dependente de LDOM com aumento na densidade capilar&#44; bem como nos efeitos adversos&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recentemente&#44; os autores avaliaram 30 homens adultos fazendo uso de 5<span class="elsevierStyleHsp" style=""></span>mg de minoxidil oral para tratamento de alopecia androgen&#233;tica &#40;AA&#41; com monitoriza&#231;&#227;o com Holter de 24 horas e monitoriza&#231;&#227;o ambulatorial da press&#227;o arterial &#40;MAPA&#41; por 24 horas antes e ap&#243;s 24 semanas de tratamento&#46; Os indiv&#237;duos n&#227;o apresentaram altera&#231;&#245;es relevantes em rela&#231;&#227;o ao Holter de 24 horas e &#224; MAPA&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Esses achados foram refor&#231;ados por avalia&#231;&#227;o com MAPA de 10 homens no in&#237;cio e ap&#243;s a primeira dose de 5<span class="elsevierStyleHsp" style=""></span>mg de minoxidil oral&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Estudos farmacocin&#233;ticos anteriores mostraram leve redu&#231;&#227;o na press&#227;o arterial e leve aumento na frequ&#234;ncia card&#237;aca em pacientes normotensos que usam minoxidil oral em doses de at&#233; 10<span class="elsevierStyleHsp" style=""></span>mg&#47;dia&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Para avaliar os potenciais efeitos adversos cardiovasculares de doses mais elevadas de minoxidil oral para queda de cabelo&#44; a dose foi aumentada de 5 para 7&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia em 11 dos 30 pacientes que completaram o estudo anterior&#46; Ap&#243;s seis semanas de uso da dose aumentada&#44; esses pacientes foram reavaliados utilizando monitoriza&#231;&#227;o por Holter de 24 horas e MAPA&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Os principais dados cl&#237;nicos e demogr&#225;ficos dos participantes s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; Os resultados da MAPA e da monitoriza&#231;&#227;o por Holter s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46; Apesar do aumento subcl&#237;nico da frequ&#234;ncia card&#237;aca&#44; o minoxidil oral 7&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia n&#227;o causou hipotens&#227;o&#44; taquicardia ou preju&#237;zo no decr&#233;scimo noturno&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Um participante referiu cefaleia&#44; e nove referiram hipertricose com minoxidil 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia por via oral&#44; o que n&#227;o levou &#224; descontinua&#231;&#227;o do tratamento&#46; Nenhum deles apresentou efeitos adversos como cefaleia&#44; taquicardia&#44; tontura&#44; edema ou ins&#244;nia ap&#243;s aumento da dose para 7&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Esses resultados refor&#231;am os efeitos anti&#8208;hipertensivos leves do minoxidil oral em indiv&#237;duos normotensos&#46; No entanto&#44; sugere&#8208;se que doses acima de 5<span class="elsevierStyleHsp" style=""></span>mg n&#227;o devam ser consideradas padr&#227;o para o tratamento da queda de cabelo&#44; e s&#243; devam ser utilizadas em circunst&#226;ncias excepcionais&#46; Nesses casos&#44; recomenda&#8208;se que os m&#233;dicos aumentem a dose gradualmente&#44; em vez de come&#231;arem com doses mais elevadas&#46; &#201; essencial considerar que mesmo doses muito baixas &#40;0&#44;25<span class="elsevierStyleHsp" style=""></span>mg&#47;dia&#41; de minoxidil oral foram associadas a efeitos adversos idiossincr&#225;ticos incomuns&#44; mas graves&#44; como derrames peric&#225;rdicos e pleurais&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Este estudo fornece dados adicionais de seguimento de uma coorte anterior&#46; Embora o tamanho da amostra tenha sido modesto&#44; n&#227;o impediu a detec&#231;&#227;o de tend&#234;ncias importantes nas manifesta&#231;&#245;es cardiovasculares em pacientes utilizando minoxidil oral 7&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Desse modo&#44; a administra&#231;&#227;o de minoxidil 7&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia para AA em adultos normotensos foi bem tolerada e resultou em leve aumento da frequ&#234;ncia card&#237;aca&#44; sem altera&#231;&#245;es concomitantes na press&#227;o arterial&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0055" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0060" class="elsevierStylePara elsevierViewall">Baltazar Dias Sanabria&#58; Coleta dos dados&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; planejamento do texto&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura e revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Yuri Chiarelli Perdomo&#58; Coleta dos dados&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; planejamento do texto&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura e revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">H&#233;lio Amante Miot&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; planejamento do texto&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura e revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Paulo M&#252;ller Ramos&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; planejamento do texto&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura e revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0080" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Suporte financeiro"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Contribui&#231;&#227;o dos autores"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflito de interesses"
        ]
        3 => array:1 [
          "titulo" => "Refer&#234;ncias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2023-06-07"
    "fechaAceptado" => "2023-08-14"
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Como citar este artigo&#58; Sanabria BD&#44; Perdomo YC&#44; Miot HA&#44; Ramos PM&#46; Oral minoxidil&#160;7&#46;5&#160;mg for hair loss increases heart rate with no change in blood pressure in 24<span class="elsevierStyleHsp" style=""></span>h Holter and 24<span class="elsevierStyleHsp" style=""></span>h ambulatory blood pressure monitoring&#46; An Bras Dermatol&#46; 2024&#59;99&#58;734&#8211;6&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Trabalho realizado na Cl&#237;nica Sanabria&#44; Campo Grande&#44; MS&#44; Brasil&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;veis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Valores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade &#40;anos&#41;&#44; m&#233;dia &#40;DP&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;9 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Peso &#40;kg&#41;&#44; m&#233;dia &#40;DP&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#44;2 &#40;13&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Ra&#231;a&#44; n &#40;&#37;&#41;</span><span class="elsevierStyleHsp" style=""></span>Branca<span class="elsevierStyleHsp" style=""></span>Parda<span class="elsevierStyleHsp" style=""></span>Preta</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;73&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Uso concomitante de medicamentos&#44; n &#40;&#37;&#41;</span><span class="elsevierStyleHsp" style=""></span>Finasterida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3644945.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Principais dados cl&#237;nicos e demogr&#225;ficos dos 11 participantes do estudo</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;veis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T0 &#40;Pr&#233;&#8208;tratamento&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T24 &#40;5 mg&#47;dia&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T30 &#40;7&#44;5 mg&#47;dia&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor<a class="elsevierStyleCrossRef" href="#tblfn0020">&#42;</a> &#40;T0<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>T30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor<a class="elsevierStyleCrossRef" href="#tblfn0020">&#42;</a> &#40;T24<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>T30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Frequ&#234;ncia card&#237;aca &#40;24h&#41;&#59; bpm</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&#237;nima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#44;3 &#40;7&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;5 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;0 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;009</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;024</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&#233;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;6 &#40;8&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;7 &#40;9&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#44;3 &#40;7&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;037</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;067&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&#44;9 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#44;5 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&#44;9 &#40;17&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Extra&#8208;s&#237;stoles &#40;eventos por 24h&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Supraventricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;2&#8211;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;2&#8211;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#8211;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;300&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;302&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ventricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#8211;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#8211;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#8211;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Press&#227;o arterial m&#233;dia</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#35;</span></a><span class="elsevierStyleItalic">&#59; mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ao longo do dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#44;4 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;0 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#44;9 &#40;9&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0422&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Em vig&#237;lia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#44;6 &#40;11&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#44;4 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;8 &#40;9&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;396&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;202&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Durante o sono&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#44;8 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#44;9 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#44;0 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;337&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;338&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Decr&#233;scimo noturno &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;15&#44;6 &#40;8&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;11&#44;0 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;14&#44;9 &#40;5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;372&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;136&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">&#8805; 10&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;73&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Press&#227;o arterial sist&#243;lica&#59; mmHg</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ao longo do dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#44;1 &#40;11&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&#44;4 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#44;9 &#40;12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;377&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Em vig&#237;lia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;9 &#40;13&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123&#44;5 &#40;10&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128&#44;9 &#40;12&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;368&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;268&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Durante o sono&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112&#44;4 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112&#44;5 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114&#44;0 &#40;10&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;418&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;419&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Press&#227;o arterial diast&#243;lica&#59; mmHg</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ao longo do dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#44;6 &#40;9&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#44;8 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;4 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;335&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;301&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Em vig&#237;lia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#44;9 &#40;10&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;4 &#40;8&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#44;3 &#40;9&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;291&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;202&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Durante o sono&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;5 &#40;8&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#44;1 &#40;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;0 &#40;8&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;304&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3644946.png"
              ]
            ]
          ]
          "notaPie" => array:4 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">M&#233;dia &#40;DP&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Mediana &#40;p25&#8211;p75&#41;&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "&#35;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">&#40;2&#42; press&#227;o diast&#243;lica<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>press&#227;o sist&#243;lica&#41;&#47;3&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Valor de p unicaudal do modelo misto generalizado&#44; corrigido &#40;<span class="elsevierStyleItalic">post&#8208;hoc</span>&#41; pelo procedimento de &#352;id&#225;k&#46;</p> <p class="elsevierStyleNotepara" id="npar0025">AST&#44; aspartato aminotransferase&#59; ALT&#44; alanina aminotransferase&#59; LDL&#44; lipoprote&#237;na de baixa densidade&#59; HDL&#44; lipoprote&#237;na de alta densidade&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Principais resultados da monitoriza&#231;&#227;o por Holter de 24 horas e da monitoriza&#231;&#227;o ambulatorial da press&#227;o arterial por 24 horas de 11 homens adultos com alopecia androgen&#233;tica avaliados antes &#40;T0&#41;&#44; ap&#243;s 24 semanas &#40;T24&#41; de tratamento com 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia de minoxidil oral e ap&#243;s seis semanas &#40;T30&#41; de tratamento com 7&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dia de minoxidil oral</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral minoxidil for hair loss&#58; update and perspectives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Muller Ramos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hair Transplant Forum International"
                        "fecha" => "2023"
                        "volumen" => "33"
                        "paginaInicial" => "93"
                        "paginaFinal" => "94"
                        "itemHostRev" => array:3 [
                          "pii" => "S0264410X19312460"
                          "estado" => "S300"
                          "issn" => "0264410X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "There is a positive dose&#8208;dependent association between low&#8208;dose oral minoxidil and its efficacy for androgenetic alopecia&#58; findings from a systematic review with meta&#8208;regression analyses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;K&#46; Gupta"
                            1 => "D&#46;C&#46; Hall"
                            2 => "M&#46; Talukder"
                            3 => "M&#46;A&#46; Bamimore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000525137"
                      "Revista" => array:6 [
                        "tituloSerie" => "Skin Appendage Disord"
                        "fecha" => "2022"
                        "volumen" => "8"
                        "paginaInicial" => "355"
                        "paginaFinal" => "361"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36161084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective cardiovascular evaluation with 24&#8208;hour Holter and 24&#8208;hour ambulatory blood pressure monitoring in men using 5&#8208;mg oral minoxidil for androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46;D&#46; Sanabria"
                            1 => "E&#46; Palmegiani"
                            2 => "A&#46;F&#46; Seron"
                            3 => "Y&#46;C&#46; Perdomo"
                            4 => "H&#46;A&#46; Miot"
                            5 => "P&#46; Muller Ramos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2022.05.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2023"
                        "volumen" => "88"
                        "paginaInicial" => "436"
                        "paginaFinal" => "437"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35597386"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Before&#8208;after study with 24&#8208;hour ambulatory blood pressure monitoring after the first dose of 5&#160;mg oral minoxidil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Jimenez-Cauhe"
                            1 => "D&#46; Saceda-Corralo"
                            2 => "A&#46; Hermosa-Gelbard"
                            3 => "O&#46;M&#46; Moreno-Arrones"
                            4 => "C&#46; Pindado-Ortega"
                            5 => "E&#46;D&#46; Berna-Rico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2022.06.1205"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2022"
                        "volumen" => "87"
                        "paginaInicial" => "e235"
                        "paginaFinal" => "e237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35973597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pharmacokinetics of 2&#46;5&#8208; to 10&#8208;mg oral doses of minoxidil in healthy volunteers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;C&#46; Fleishaker"
                            1 => "N&#46;A&#46; Andreadis"
                            2 => "I&#46;R&#46; Welshman"
                            3 => "C&#46;E&#46; Wright 3rd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/j.1552-4604.1989.tb03307.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol"
                        "fecha" => "1989"
                        "volumen" => "29"
                        "paginaInicial" => "162"
                        "paginaFinal" => "167"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2715373"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pericardial&#44; pleural effusion and anasarca&#58; a rare complication of low&#8208;dose oral minoxidil for hair loss"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46;C&#46; Dlova"
                            1 => "T&#46; Jacobs"
                            2 => "S&#46; Singh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdcr.2022.07.044"
                      "Revista" => array:7 [
                        "tituloSerie" => "JAAD Case Rep"
                        "fecha" => "2022"
                        "volumen" => "28"
                        "paginaInicial" => "94"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36117778"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0264410X20310847"
                          "estado" => "S300"
                          "issn" => "0264410X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/26662752/0000009900000005/v2_202409060549/S2666275224001164/v2_202409060549/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "95147"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Cartas - Investiga&#231;&#227;o"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/26662752/0000009900000005/v2_202409060549/S2666275224001164/v2_202409060549/pt/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224001164?idApp=UINPBA00008Z"
]
Compartilhar
Informação da revista
Vol. 99. Núm. 5.
Páginas 734-736 (1 setembro 2024)
Compartilhar
Compartilhar
Baixar PDF
Mais opções do artigo
Visitas
3721
Vol. 99. Núm. 5.
Páginas 734-736 (1 setembro 2024)
Cartas ‐ Investigação
Acesso de texto completo
Minoxidil 7,5mg oral para queda de cabelo aumenta a frequência cardíaca sem alteração da pressão arterial no Holter de 24h e na monitorização ambulatorial da pressão arterial de 24h
Visitas
3721
Baltazar Dias Sanabriaa, Yuri Chiarelli Perdomob, Hélio Amante Miotc, Paulo Müller Ramosc,
Autor para correspondência
dermato.paulo@gmail.com

Autor para correspondência.
a Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, Brasil
b Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brasil
c Departamento de Infectologia, Dermatologia, Diagnóstico por Imagem e Radioterapia, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brasil
Este item recebeu
Informação do artigo
Texto Completo
Bibliografia
Baixar PDF
Estatísticas
Tabelas (2)
Tabela 1. Principais dados clínicos e demográficos dos 11 participantes do estudo
Tabela 2. Principais resultados da monitorização por Holter de 24 horas e da monitorização ambulatorial da pressão arterial por 24 horas de 11 homens adultos com alopecia androgenética avaliados antes (T0), após 24 semanas (T24) de tratamento com 5mg/dia de minoxidil oral e após seis semanas (T30) de tratamento com 7,5mg/dia de minoxidil oral
Mostrar maisMostrar menos
Texto Completo
Prezado Editor,

O minoxidil oral em baixa dose (MOBD) constitui alternativa importante para o tratamento de diferentes causas de queda de cabelo.1 Entretanto, seus efeitos adversos cardiovasculares, como taquicardia, hipotensão e edema, continuam a ser uma preocupação mesmo em doses baixas.

Em geral, a dose padrão para o tratamento da hipertensão varia de 10 a 40mg/dia, e não há consenso sobre a dosagem ideal para o tratamento da queda de cabelo.2

Uma ampla gama de doses (de 0,25 a 5mg/dia) foi avaliada em estudos clínicos, sem exceder 5mg/dia.2 Recentemente, uma metanálise demonstrou associação positiva dose‐dependente de LDOM com aumento na densidade capilar, bem como nos efeitos adversos.2

Recentemente, os autores avaliaram 30 homens adultos fazendo uso de 5mg de minoxidil oral para tratamento de alopecia androgenética (AA) com monitorização com Holter de 24 horas e monitorização ambulatorial da pressão arterial (MAPA) por 24 horas antes e após 24 semanas de tratamento. Os indivíduos não apresentaram alterações relevantes em relação ao Holter de 24 horas e à MAPA.3 Esses achados foram reforçados por avaliação com MAPA de 10 homens no início e após a primeira dose de 5mg de minoxidil oral.4

Estudos farmacocinéticos anteriores mostraram leve redução na pressão arterial e leve aumento na frequência cardíaca em pacientes normotensos que usam minoxidil oral em doses de até 10mg/dia.5 Para avaliar os potenciais efeitos adversos cardiovasculares de doses mais elevadas de minoxidil oral para queda de cabelo, a dose foi aumentada de 5 para 7,5mg/dia em 11 dos 30 pacientes que completaram o estudo anterior. Após seis semanas de uso da dose aumentada, esses pacientes foram reavaliados utilizando monitorização por Holter de 24 horas e MAPA.

Os principais dados clínicos e demográficos dos participantes são apresentados na tabela 1. Os resultados da MAPA e da monitorização por Holter são apresentados na tabela 2. Apesar do aumento subclínico da frequência cardíaca, o minoxidil oral 7,5mg/dia não causou hipotensão, taquicardia ou prejuízo no decréscimo noturno.

Tabela 1.

Principais dados clínicos e demográficos dos 11 participantes do estudo

Variáveis  Valores 
Idade (anos), média (DP)  37,9 (7,7) 
   
Peso (kg), média (DP)  86,2 (13,7) 
   
Raça, n (%)BrancaPardaPreta 
8 (73%) 
2 (18%) 
1 (9%) 
Uso concomitante de medicamentos, n (%)Finasterida  2 (18%) 
Tabela 2.

Principais resultados da monitorização por Holter de 24 horas e da monitorização ambulatorial da pressão arterial por 24 horas de 11 homens adultos com alopecia androgenética avaliados antes (T0), após 24 semanas (T24) de tratamento com 5mg/dia de minoxidil oral e após seis semanas (T30) de tratamento com 7,5mg/dia de minoxidil oral

Variáveis  T0 (Pré‐tratamento)  T24 (5 mg/dia)  T30 (7,5 mg/dia)  p‐valor* (T0×T30)  p‐valor* (T24×T30) 
Frequência cardíaca (24h); bpma           
Mínima  47,3 (7,4)  48,5 (6,4)  53,0 (5,5)  0,009  0,024 
Média  72,6 (8,7)  75,7 (9,1)  81,3 (7,8)  0,037  0,067 
Máxima  129,9 (15,8)  124,5 (11,1)  131,9 (17,5)  0,400  0,142 
Extra‐sístoles (eventos por 24h)b           
Supraventricular  3 (2–14)  4 (2–11)  2 (1–6)  0,300  0,302 
Ventricular  0 (0–0)  0 (0–1)  0 (0–0)  0,416  0,330 
Pressão arterial média#; mmHg           
Ao longo do dia  90,4 (10,4)  87,0 (7,7)  89,9 (9,7)  0422  0,298 
Em vigília  94,6 (11,2)  89,4 (8,6)  93,8 (9,8)  0,396  0,202 
Durante o sono  77,8 (9,3)  76,9 (7,7)  80,0 (8,6)  0,337  0,338 
Decréscimo noturno (%)  −15,6 (8,1)  −11,0 (6,3)  −14,9 (5,7)  0,372  0,136 
≥ 10%  8 (73%)  3 (30%)  5 (50%)  0,096  0,016 
Pressão arterial sistólica; mmHga           
Ao longo do dia  124,1 (11,7)  121,4 (9,3)  124,9 (12,4)  0,416  0,377 
Em vigília  127,9 (13,0)  123,5 (10,2)  128,9 (12,7)  0,368  0,268 
Durante o sono  112,4 (11,1)  112,5 (9,3)  114,0 (10,8)  0,418  0,419 
Pressão arterial diastólica; mmHga           
Ao longo do dia  73,6 (9,9)  69,8 (7,9)  72,4 (9,0)  0,335  0,301 
Em vigília  77,9 (10,9)  72,4 (8,8)  76,3 (9,2)  0,291  0,202 
Durante o sono  60,5 (8,9)  59,1 (8,4)  63,0 (8,7)  0,304  0,257 
a

Média (DP).

b

Mediana (p25–p75).

#

(2* pressão diastólica+pressão sistólica)/3.

*

Valor de p unicaudal do modelo misto generalizado, corrigido (post‐hoc) pelo procedimento de Šidák.

AST, aspartato aminotransferase; ALT, alanina aminotransferase; LDL, lipoproteína de baixa densidade; HDL, lipoproteína de alta densidade.

Um participante referiu cefaleia, e nove referiram hipertricose com minoxidil 5mg/dia por via oral, o que não levou à descontinuação do tratamento. Nenhum deles apresentou efeitos adversos como cefaleia, taquicardia, tontura, edema ou insônia após aumento da dose para 7,5mg/dia.

Esses resultados reforçam os efeitos anti‐hipertensivos leves do minoxidil oral em indivíduos normotensos. No entanto, sugere‐se que doses acima de 5mg não devam ser consideradas padrão para o tratamento da queda de cabelo, e só devam ser utilizadas em circunstâncias excepcionais. Nesses casos, recomenda‐se que os médicos aumentem a dose gradualmente, em vez de começarem com doses mais elevadas. É essencial considerar que mesmo doses muito baixas (0,25mg/dia) de minoxidil oral foram associadas a efeitos adversos idiossincráticos incomuns, mas graves, como derrames pericárdicos e pleurais.6

Este estudo fornece dados adicionais de seguimento de uma coorte anterior. Embora o tamanho da amostra tenha sido modesto, não impediu a detecção de tendências importantes nas manifestações cardiovasculares em pacientes utilizando minoxidil oral 7,5mg/dia.

Desse modo, a administração de minoxidil 7,5mg/dia para AA em adultos normotensos foi bem tolerada e resultou em leve aumento da frequência cardíaca, sem alterações concomitantes na pressão arterial.

Suporte financeiro

Nenhum.

Contribuição dos autores

Baltazar Dias Sanabria: Coleta dos dados, aprovação da versão final do manuscrito; planejamento do texto; elaboração e redação do manuscrito; revisão crítica da literatura e revisão crítica do manuscrito.

Yuri Chiarelli Perdomo: Coleta dos dados, aprovação da versão final do manuscrito; planejamento do texto; elaboração e redação do manuscrito; revisão crítica da literatura e revisão crítica do manuscrito.

Hélio Amante Miot: Aprovação da versão final do manuscrito; planejamento do texto; elaboração e redação do manuscrito; revisão crítica da literatura e revisão crítica do manuscrito.

Paulo Müller Ramos: Aprovação da versão final do manuscrito; planejamento do texto; elaboração e redação do manuscrito; revisão crítica da literatura e revisão crítica do manuscrito.

Conflito de interesses

Nenhum.

Referências
[1]
P. Muller Ramos.
Oral minoxidil for hair loss: update and perspectives.
Hair Transplant Forum International, 33 (2023), pp. 93-94
[2]
A.K. Gupta, D.C. Hall, M. Talukder, M.A. Bamimore.
There is a positive dose‐dependent association between low‐dose oral minoxidil and its efficacy for androgenetic alopecia: findings from a systematic review with meta‐regression analyses.
Skin Appendage Disord, 8 (2022), pp. 355-361
[3]
B.D. Sanabria, E. Palmegiani, A.F. Seron, Y.C. Perdomo, H.A. Miot, P. Muller Ramos.
Prospective cardiovascular evaluation with 24‐hour Holter and 24‐hour ambulatory blood pressure monitoring in men using 5‐mg oral minoxidil for androgenetic alopecia.
J Am Acad Dermatol, 88 (2023), pp. 436-437
[4]
J. Jimenez-Cauhe, D. Saceda-Corralo, A. Hermosa-Gelbard, O.M. Moreno-Arrones, C. Pindado-Ortega, E.D. Berna-Rico, et al.
Before‐after study with 24‐hour ambulatory blood pressure monitoring after the first dose of 5 mg oral minoxidil.
J Am Acad Dermatol, 87 (2022), pp. e235-e237
[5]
J.C. Fleishaker, N.A. Andreadis, I.R. Welshman, C.E. Wright 3rd.
The pharmacokinetics of 2.5‐ to 10‐mg oral doses of minoxidil in healthy volunteers.
J Clin Pharmacol, 29 (1989), pp. 162-167
[6]
N.C. Dlova, T. Jacobs, S. Singh.
Pericardial, pleural effusion and anasarca: a rare complication of low‐dose oral minoxidil for hair loss.
JAAD Case Rep, 28 (2022), pp. 94-96

Como citar este artigo: Sanabria BD, Perdomo YC, Miot HA, Ramos PM. Oral minoxidil 7.5 mg for hair loss increases heart rate with no change in blood pressure in 24h Holter and 24h ambulatory blood pressure monitoring. An Bras Dermatol. 2024;99:734–6.

Trabalho realizado na Clínica Sanabria, Campo Grande, MS, Brasil.

Baixar PDF
Idiomas
Anais Brasileiros de Dermatologia (Portuguese)
Opções de artigo
Ferramentas
en pt
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.