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with some of them morphologically like a comma or a tadpole&#44; in the superficial dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; A diagnosis of sporadic linear syringoma was made&#46; As it is a benign disease with no malignant potential&#44; the patient has been followed up regularly without any treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">Syringoma is a benign neoplasm that derives from eccrine sweat gland ducts&#46; The typical clinical manifestation is single or multiple skin-color or yellowish papules on the lower eyelid&#44; 1 to 3<span class="elsevierStyleHsp" style=""></span>mm in size&#46; Friedman and Butler classified syringoma into 4 clinical variants&#58; generalized forms&#44; localized forms&#44; familial forms and variants associated with Down&#8217;s syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Differential diagnosis of syringoma based on a variety of clinical manifestations includes milia&#44; xanthoma&#44; hidrocystoma&#44; trichoepithelioma&#44; and flat warts&#44; especially for the eyelids&#59; other considerations include cutaneous mastocytosis&#44; fibrofolliculomas&#44; vellus hair cysts&#44; angiofibroma&#44; and fibroelastic papulosis&#44; lichen planus&#44; steatocystoma multiplex&#44; eruptive vellus hair cysts&#44; disseminated granuloma annulare&#44; secondary syphilis and so on&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Diagnosis can be confirmed by typical histopathologic manifestations&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Though syringoma is a common ailment&#44; the pathogenesis remains unclear&#44; some investigators have suggested that syringomas may be caused by hormonal factors&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The linear arrangement along Blascko&#8217;s lines is unusual and indicated the genetic association in pathogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However&#44; we could not find any congenital abnormalities in the present case&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">As we all know&#44; syringoma rarely shows the unilateral or linear distribution&#46; There have been only 4 reports of unilateral linear syringoma&#44; all involving the upper trunk and limb&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;9</span></a> We learned from previously reported cases that linear syringoma usually presents clinically quite similar to ordinary syringoma&#46; Nevertheless&#44; in the present case&#44; the size of most skin lesions was larger than the usual size and the color was different&#44; which reminds dermatologists of the necessity to consider syringoma in the differential diagnosis of unilateral linear papular or plaque skin lesions&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">This work is supported by <span class="elsevierStyleGrantSponsor" id="gs0005">Medical Science and Technology Research Projects in Guangdong Province</span> &#40;<span class="elsevierStyleGrantNumber" refid="gs0005">A2021365</span>&#41; and <span class="elsevierStyleGrantSponsor" id="gs0010">Science and Technology Plan Projects of Zhuhai</span> &#40;<span class="elsevierStyleGrantNumber" refid="gs0010">ZH2202200003HJL</span>&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors&#39; contributions</span><p id="par0030" class="elsevierStylePara elsevierViewall">Danyi Huang took effective participation in research orientation and completed the preparation and writing of the manuscript&#46; Yanqing Chen was in charge of the data collection&#44; analysis and interpretation&#46; Jianjian Li helped with data collection&#46; Han Ma formed the study conception and planning and approved the final version of the manuscript&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Vol. 98. Núm. 2.
Páginas 263-265 (1 março 2023)
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Vol. 98. Núm. 2.
Páginas 263-265 (1 março 2023)
Letter - Clinical
Open Access
Unilateral linear syringoma on the right chest and arm
Visitas
4418
Danyi Huang1, Yanqing Chen1, Jianjian Li, Han Ma
Autor para correspondência
drmahan@sina.com

Corresponding author.
Department of Dermatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China
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Dear Editor,

A 25-year-old man presented to the dermatology department with an 8-year history of yellowish-brown skin lesions on his right chest, axilla, and arm. The lesions first appeared on the right chest and increased in number and size gradually, showing a linear distribution, with no pain or itching. He was otherwise healthy with no other special medical history. Physical examination revealed a yellowish-brown firm, smooth papules and plaques on his right chest, axilla, and arm, ranging from 1 to 10mm in diameter (Figs. 14). The distribution of the lesions followed Blaschko's lines. Histopathology showed multiple small tubules, cysts, and nests forming by epithelial proliferation, with some of them morphologically like a comma or a tadpole, in the superficial dermis (Fig. 5). A diagnosis of sporadic linear syringoma was made. As it is a benign disease with no malignant potential, the patient has been followed up regularly without any treatment.

Fig. 1.

Physical examination revealed yellowish-brown firm, smooth papules, and plaques on his right chest. Distribution of the lesions followed Blaschko's lines.

(0.2MB).
Fig. 2.

Closer look on the right chest. There is a wound after skin biopsy at the bottom.

(0.18MB).
Fig. 3.

Lesions on the axilla.

(0.15MB).
Fig. 4.

Lesions on the right upper limb.

(0.11MB).
Fig. 5.

Histopathology showed multiple small tubules, cysts, and nest forming by epithelial proliferation, with some of them morphologically like a comma or a tadpole, in the superficial dermis (Hematoxilin & eosin, X40).

(0.28MB).
Discussion

Syringoma is a benign neoplasm that derives from eccrine sweat gland ducts. The typical clinical manifestation is single or multiple skin-color or yellowish papules on the lower eyelid, 1 to 3mm in size. Friedman and Butler classified syringoma into 4 clinical variants: generalized forms, localized forms, familial forms and variants associated with Down’s syndrome.1 Differential diagnosis of syringoma based on a variety of clinical manifestations includes milia, xanthoma, hidrocystoma, trichoepithelioma, and flat warts, especially for the eyelids; other considerations include cutaneous mastocytosis, fibrofolliculomas, vellus hair cysts, angiofibroma, and fibroelastic papulosis, lichen planus, steatocystoma multiplex, eruptive vellus hair cysts, disseminated granuloma annulare, secondary syphilis and so on.2,3 Diagnosis can be confirmed by typical histopathologic manifestations.

Though syringoma is a common ailment, the pathogenesis remains unclear, some investigators have suggested that syringomas may be caused by hormonal factors.4 The linear arrangement along Blascko’s lines is unusual and indicated the genetic association in pathogenesis.5 However, we could not find any congenital abnormalities in the present case.

As we all know, syringoma rarely shows the unilateral or linear distribution. There have been only 4 reports of unilateral linear syringoma, all involving the upper trunk and limb.6–9 We learned from previously reported cases that linear syringoma usually presents clinically quite similar to ordinary syringoma. Nevertheless, in the present case, the size of most skin lesions was larger than the usual size and the color was different, which reminds dermatologists of the necessity to consider syringoma in the differential diagnosis of unilateral linear papular or plaque skin lesions.

Financial support

This work is supported by Medical Science and Technology Research Projects in Guangdong Province (A2021365) and Science and Technology Plan Projects of Zhuhai (ZH2202200003HJL).

Authors' contributions

Danyi Huang took effective participation in research orientation and completed the preparation and writing of the manuscript. Yanqing Chen was in charge of the data collection, analysis and interpretation. Jianjian Li helped with data collection. Han Ma formed the study conception and planning and approved the final version of the manuscript.

Conflicts of interest

None declared.

References
[1]
S.J. Friedman, D.F. Butler.
Syringoma presenting as milia.
J Am Acad Dermatol., 16 (1987), pp. 310-314
[2]
K. Williams, K. Shinkai.
Evaluation and management of the patient with multiple syringomas: a systematic review of the literature.
J Am Acad Dermatol, 74 (2016), pp. 1234-1240
[3]
B.B. Beers.
An eruption of asymptomatic brown papules. Eruptive disseminated syringomas.
Arch Dermatol., 126 (1990),
[4]
N. Bal, E. Aslan, F. Kayaselcuk, E. Tarim, I. Tuncer.
Vulvar syringoma aggravated by pregnancy.
Pathol Oncol Res., 9 (2003), pp. 196-197
[5]
C. Moss, S. Larkins, M. Stacey, A. Blight, P.A. Farndon, E.V. Davison.
Epidermal mosaicism and Blaschko’s lines.
J Med Genet., 30 (1993), pp. 752-755
[6]
D. Creamer, A. Macdonald, W.A. Griffiths.
Unilateral linear syringomata. A case report.
Clin Exp Dermatol., 24 (1999), pp. 428-430
[7]
Y. Hayashi, M. Tanaka, S. Nakajima, M. Ozeki, T. Inoue, S. Ishizaki, et al.
Unilateral linear syringoma in a Japanese female: dermoscopic differentiation from lichen planus linearis.
Dermatol Reports., 3 (2011), pp. e42
[8]
H.I. Chi.
A case of unusual syringoma: unilateral linear distribution and plaque formation.
[9]
C.W. Yung, K. Soltani, J.E. Bernstein, A.L. Lorincz.
Unilateral linear nevoidal syringoma.
J Am Acad Dermatol., 4 (1981), pp. 412

Study conducted at the Department of Dermatology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai (ZH), Guangdong (GD), China (CHN).

Danyi Huang and Yanqing Chen contributed equally to this work.

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