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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hidradenitis Suppurativa &#40;HS&#41; is a debilitating&#44; potentially mutilating&#44; chronic&#44; inflammatory systemic skin disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> A long delay between HS onset and its diagnosis is common&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a> and it appears to have an impact in response to biological treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Currently&#44; adalimumab is the sole biological approved for the treatment of moderate-to-severe HS&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We conducted a retrospective study to analyze HS patients treated with adalimumab at a terciary health care center in Lisboa&#44; between 2016 and 2019&#46; Epidemiological&#44; clinical&#44; and therapeutic information was retrieved&#46; HS activity and response to adalimumab were monitored at baseline and Weeks 16 &#40;W16&#41;&#44; 24 &#40;W24&#41;&#44; and 52 &#40;W52&#41;&#46; A baseline observation at the clinic and a minimum of 16 weeks of follow-up were required for inclusion&#46; Patients on adalimumab increased doses and cases of paradoxical HS were excluded&#46; Patients could have adjuvant medical treatments when considered suitable&#46; Severity assessment tools were employed&#44; namely Hurley Staging System&#44; International Hidradenitis Suppurativa Severity Score System &#40;iHS4&#41;&#44; Dermatology Life Quality Index &#40;DLQI&#41;&#44; and visual analog scale for pain &#40;VAS pain&#41;&#46; Response to treatment was evaluated using Hidradenitis Suppurativa Clinical Response &#40;HISCR&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Analysis was performed using IBM SPSS Version 24&#46; Independent samples <span class="elsevierStyleItalic">t</span>-Test was used to test differences between continuous and categorical variables at a significance level of 0&#46;05&#46; Fischer&#8217;s exact test was used to test differences between 2 categorical variables at a significance level of 0&#46;05&#44; two-tailed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Out of 198 HS patients&#44; 51 started treatments with a biological agent and&#44; of these&#44; 36 were on adalimumab and met the study criteria&#46; The comparison between these 36 patients under adalimumab and the 147 patients without biological treatment can be found in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; At baseline&#44; the severity was significantly higher in the adalimumab group&#44; using both objective &#40;Hurley&#58; 2&#46;6 vs&#46; 1&#46;7&#59; p&#160;&#60;&#160;0&#46;001&#59; iHS4&#58; 16&#46;7 vs&#46; 4&#46;1&#59; p&#160;&#60;&#160;0&#46;001&#41; and subjective criteria &#40;DLQI&#58; 15&#46;4 vs&#46; 10&#46;4&#44; p&#160;&#61;&#160;0&#46;002&#41;&#46; Most patients on adalimumab presented with severe disease &#40;iHS4&#160;&#62;&#160;10&#58; 75&#37;&#59; n&#160;&#61;&#160;27&#59; iHS4&#160;&#8804;&#160;10&#58; 25&#37;&#59; n&#160;&#61;&#160;9&#41;&#44; 58&#46;3&#37; &#40;n&#160;&#61;&#160;21&#41; with Hurley III and 41&#46;7&#37; &#40;n&#160;&#61;&#160;15&#41; with Hurley II&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">At W16&#44; HISCR was achieved in 27 patients &#40;75&#37;&#41;&#46; This percentage was similar in patients with moderate &#40;89&#37;&#44; n&#160;&#61;&#160;8&#41; and severe disease &#40;70&#46;4&#37;&#44; n&#160;&#61;&#160;19&#41; &#40;p&#160;&#62;&#160;0&#46;05&#41;&#44; The mean iHS4 was reduced from 16&#46;7 to 7&#46;2 &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46;The time from HS onset to diagnosis was similar &#40;6&#46;7 years vs&#46; 11&#46;8&#59; p&#160;&#61;&#160;0&#46;282&#41;&#46; At W24 the iHS4 reduction was significant &#40;mean iHS4&#160;&#61;&#160;6&#46;5&#59; &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; At W52&#44; the mean iHS4 was 4&#46;7 &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; and HISCR was still achieved in 76&#46;7&#37; &#40;n&#160;&#61;&#160;23&#47;30&#41; of the patients&#46; Between baseline and W52&#44; DLQI and VAS pain shifted from a mean value of 15&#46;4 to 10&#46;5 &#40;p&#160;&#61;&#160;0&#46;001&#41; and 4&#46;4 to 1&#46;8 &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; respectively&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Within the first 16 weeks&#44; in order to successfully control HS inflammatory activity&#44; adjuvant&#44; transitory&#44; and medical treatments were employed in 72&#37; &#40;n&#160;&#61;&#160;26&#41; of the cases&#46; During the remaining period&#44; adjuvant therapeutics were needed in 20 patients to control episodic flares&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Addressing the differences between patients staged as Hurley II and III &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#44; 82&#37; &#40;n&#160;&#61;&#160;9&#41; of male patients were classified as Hurley III&#44; compared to 48&#37; &#40;n&#160;&#61;&#160;12&#41; of females who presented such severity &#40;p&#160;&#61;&#160;0&#46;044&#41;&#46; At baseline&#44; Hurley II patients presented similar severity &#40;mean iHS4&#58; 13&#46;7 vs&#46; 18&#46;8&#59; p&#160;&#61;&#160;0&#46;085&#41; but with a significantlower number of draining fistulae &#40;2&#46;0 vs&#46; 3&#46;9&#59; p&#160;&#61;&#160;0&#46;002&#41;&#46; While both groups recorded HS improvement under treatment&#44; significantly better control of disease activity at W52 was observed within Hurley II patients &#40;iHS4&#58; 1&#46;3 vs&#46; 7&#59; p&#160;&#61;&#160;0&#46;003&#41;&#46; Otherwise&#44; the response to adalimumab measured by HISCR achievement at W16 and W52 was superior and similar in Hurley II patients &#40;W16&#58; 93&#37; vs&#46; 61&#46;9&#37;&#44; p&#160;&#61;&#160;0&#46;051&#59; W52&#58; 83&#46;3&#37; vs&#46; 72&#46;2&#37;&#59; p&#160;&#61;&#160;0&#46;669&#41;&#44; respectively&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Considering the last clinical evaluation of all patients&#44; 78&#37; &#40;n&#160;&#61;&#160;28&#41; witnessed a reduction of at least 50&#37; of their iHS4 at baseline &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; Within the group that did not achieve such a response &#40;n&#160;&#61;&#160;8&#41;&#44; half presented with more than five draining fistulas at baseline and two of them switched biological treatment&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Clinical trials have shown that adalimumab is an effective treatment for moderate-to-severe HS with inadequate response to conventional treatments&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> with HISCR achievement rates ranging from 40&#37;&#8210;60&#37; in monotherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6&#44;8&#44;9</span></a> The present study&#8217;s results showed superiority in terms of HISCR achievement at W12&#47;16&#44; W24 and W52 when compared to PIONEER I and II clinical trials and to Marzano et al&#46; multicentre study&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6&#8211;8</span></a> We associated the better results &#40;75&#37; HISCR achievers at W16&#41; with the use of adjuvant intralesional and systemic therapeutics&#46; This&#44; we believe&#44; may be a necessary practice in a real-life setting in order to further reduce inflammation and pain in notably severe cases along with adalimumab induction&#46; Additionally&#44; as flares can still be observed in patients on adalimumab monotherapy&#44; adjuvant therapies may be required to treatment optimization&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The present results showed a greater response to adalimumab in Hurley II patients when compared to Hurley III&#44; especially observable in the mean iHS4 reduction&#46; Also&#44; the delay to HS diagnosis was higher in the Hurley III group&#46; These findings follow the trend within the &#8220;Window of Opportunity&#8221; hypothesis&#44; which has postulated an inverse relationship between HS duration and&#47;or diagnostic delay and adalimumab effectiveness&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;9&#44;10</span></a> It has been suggested that starting adalimumab earlier&#44; when HS is characterized by reversible lesions&#44; encompasses the potential to prevent disease progression&#44; development of fistulas&#44; and permanent deformities&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;10</span></a> Hurley III patients enclose a more severe clinical status&#44; which may justify lower effectiveness of adalimumab&#46; The present findings further highlight the importance of precocious diagnosis&#44; in order to effectively treat and prevent HS natural evolution&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; adalimumab is a useful and effective treatment for HS although in monotherapy may not be sufficient to allow optimal control in some patients&#46; This study supports the need for a proactive treatment&#44; underlining the importance of early referral&#44; the precocious use of adalimumab&#44; and of the benefit of adjuvant therapies in patients under adalimumab&#46; We highlight that real-life evidence is still scarce and more studies must be performed to allow more suitable evidence-based therapeutic guidelines&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors received no financial support for the research&#44; authorship&#44; and&#47;or publication of this article&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0065" class="elsevierStylePara elsevierViewall">Jos&#233; Miguel Neves&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; statistical analysis&#59; study conception and planning&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">N&#233;lia Cunha&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; statistical analysis&#59; study conception and planning&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Andr&#233; Lencastre&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; statistical analysis&#59; study conception and planning&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Joana Cabete&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; statistical analysis&#59; study conception and planning&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declared no potential conflicts of interest with respect to the research&#44; authorship&#44; and&#47;or publication of this article&#46;</p></span></span>"
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    "fechaRecibido" => "2021-09-21"
    "fechaAceptado" => "2021-12-22"
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        "etiqueta" => "&#8902;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Study conducted at the Department of Dermatology and Venereology&#44; Hospital de Santo Ant&#243;nio dos Capuchos&#44; Centro Hospitalar Universit&#225;rio de Lisboa Central&#44; Lisbon&#44; Portugal&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Adalimumab patients &#40;n&#160;&#61;&#160;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Non biological &#40;n&#160;&#61;&#160;147&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Statistical significance&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fermale prevalence&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;69&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">101 &#40;68&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;981&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HS onset &#40;years&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;192&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diagnosis delay &#40;years&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;151&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Number of comorbidities<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;206&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Number of affected sites<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;350&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Past&#47;present smoking history&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;72&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95 &#40;64&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Initial iHS4<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Hurley stage<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">15&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hurley III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Statistical significance &#40;p&#60;0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Number of affected sites&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HS onset &#40;years&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;595&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diagnosis delay &#40;years&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;508&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Initial iHS4 &#40;n&#61;36&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;085&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Initial number of draining fistulas &#40;n&#61;36&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">W16 iHS4 &#40;n&#61;36&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;038&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">W24 iHS4 &#40;n&#61;33&#41;<a class="elsevierStyleCrossRefs" href="#tblfn0010"><span class="elsevierStyleSup">a&#44;b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">W52 iHS4 &#40;n&#61;30&#41;<a class="elsevierStyleCrossRefs" href="#tblfn0010"><span class="elsevierStyleSup">a&#44;c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">W52 number of draining fistulas &#40;n&#61;30&#41;<a class="elsevierStyleCrossRefs" href="#tblfn0010"><span class="elsevierStyleSup">a&#44;c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">W16 HISCR &#40;n&#61;36&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#46;3&#37; &#40;n&#61;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;9&#37; &#40;n&#61;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;051&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">W52 HISCR &#40;n&#61;30&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;3&#37; &#40;n&#61;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;2&#37; &#40;n&#61;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;669&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">W52 Adalimumab only &#40;n&#61;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">41&#46;7&#37; &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;8&#37; &#40;n&#61;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;461&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "identificador" => "tblfn0010"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">n&#61;33 &#8210; two patients were evaluated only at W16 and one had adalimumab discontinued due to primary failure&#46;</p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">n&#61;30 &#8211; two patients had their last evaluation at W24 and one had adalimumab discontinued due to secondary failure&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinical characterization and therapeutic response of Hurley II and Hurley III HS groups&#46;</p>"
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                      "titulo" => "Hidradenitis suppurativa&#47;acne inversa&#58; a practical framework for treatment optimization &#8211; systematic review and recommendations from the HS ALLIANCE working group"
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                        0 => array:2 [
                          "etal" => true
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                            0 => "C&#46;C&#46; Zouboulis"
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                            2 => "J&#46;L&#46; Dickinson-Blok"
                            3 => "W&#46; Gulliver"
                            4 => "B&#46; Horv&#225;th"
                            5 => "R&#46; Hughes"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Eur Acad Dermatology Venereol"
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                        "volumen" => "33"
                        "paginaInicial" => "19"
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                      "titulo" => "Targeted treatments for hidradenitis suppurativa&#58; a review of the current literature and ongoing clinical trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Maarouf"
                            1 => "A&#46;K&#46; Clark"
                            2 => "D&#46;E&#46; Lee"
                            3 => "V&#46;Y&#46; Shi"
                          ]
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                    0 => array:2 [
                      "doi" => "10.1080/09546634.2017.1395806"
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                        "tituloSerie" => "J Dermatolog Treat"
                        "fecha" => "2018"
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29098911"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hidradenitis suppurativa&#58; Advances in diagnosis and treatment"
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                          "autores" => array:2 [
                            0 => "D&#46;M&#46;L&#46; Saunte"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA - J Am Med Assoc"
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                        "volumen" => "318"
                        "paginaInicial" => "2019"
                        "paginaFinal" => "2032"
                      ]
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                    0 => array:2 [
                      "titulo" => "Evidence for a &#8216;window of opportunity&#8217; in hidradenitis suppurativa treated with adalimumab&#58; a retrospective&#44; real-life multicentre cohort study"
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                            0 => "A&#46;V&#46; Marzano"
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                            3 => "C&#46; Moltrasio"
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Journal Information
Vol. 97. Issue 6.
Pages 816-819 (1 November 2022)
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Vol. 97. Issue 6.
Pages 816-819 (1 November 2022)
Research Letter
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Treating hidradenitis suppurativa patients with adalimumab: a real-life experience of a tertiary care center in Lisboa, Portugal
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José Miguel Neves
Corresponding author
josemoneves@gmail.com

Corresponding author.
, Nélia Cunha, André Lencastre, Joana Cabete
Department of Dermatology and Venereology, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal
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Dear Editor,

Hidradenitis Suppurativa (HS) is a debilitating, potentially mutilating, chronic, inflammatory systemic skin disease.1–3 A long delay between HS onset and its diagnosis is common,1,4,5 and it appears to have an impact in response to biological treatment.5 Currently, adalimumab is the sole biological approved for the treatment of moderate-to-severe HS.

We conducted a retrospective study to analyze HS patients treated with adalimumab at a terciary health care center in Lisboa, between 2016 and 2019. Epidemiological, clinical, and therapeutic information was retrieved. HS activity and response to adalimumab were monitored at baseline and Weeks 16 (W16), 24 (W24), and 52 (W52). A baseline observation at the clinic and a minimum of 16 weeks of follow-up were required for inclusion. Patients on adalimumab increased doses and cases of paradoxical HS were excluded. Patients could have adjuvant medical treatments when considered suitable. Severity assessment tools were employed, namely Hurley Staging System, International Hidradenitis Suppurativa Severity Score System (iHS4), Dermatology Life Quality Index (DLQI), and visual analog scale for pain (VAS pain). Response to treatment was evaluated using Hidradenitis Suppurativa Clinical Response (HISCR).

Analysis was performed using IBM SPSS Version 24. Independent samples t-Test was used to test differences between continuous and categorical variables at a significance level of 0.05. Fischer’s exact test was used to test differences between 2 categorical variables at a significance level of 0.05, two-tailed.

Out of 198 HS patients, 51 started treatments with a biological agent and, of these, 36 were on adalimumab and met the study criteria. The comparison between these 36 patients under adalimumab and the 147 patients without biological treatment can be found in Table 1. At baseline, the severity was significantly higher in the adalimumab group, using both objective (Hurley: 2.6 vs. 1.7; p < 0.001; iHS4: 16.7 vs. 4.1; p < 0.001) and subjective criteria (DLQI: 15.4 vs. 10.4, p = 0.002). Most patients on adalimumab presented with severe disease (iHS4 > 10: 75%; n = 27; iHS4 ≤ 10: 25%; n = 9), 58.3% (n = 21) with Hurley III and 41.7% (n = 15) with Hurley II.

Table 1.

Epidemiological and clinical data comparing adalimumab and non-biological HS patients.

Features  Adalimumab patients (n = 36)  Non biological (n = 147)  Statistical significance 
Fermale prevalence, n (%)  25 (69.4%)  101 (68.7%)  0.981 
HS onset (years)a  27.7  24.7  0.192 
Diagnosis delay (years)a  8.0  10.8  0.151 
Number of comorbiditiesa  3.8  3.4  0.206 
Number of affected sitesa  3.5  2.7  0.003 
BMIa  29.3  28.3  0.350 
Past/present smoking history, n (%)  26 (72.2%)  95 (64.6%)  0.558 
Initial iHS4a  16.7  4.1  <0.001 
Hurley stagea  2.6  1.7  <0.001 
Initial DLQIa  15.4  10.4  0.001 

BMI, Body Mass Index; HS, Hidradenitis Suppurativa.

a

Data are reported as means.

At W16, HISCR was achieved in 27 patients (75%). This percentage was similar in patients with moderate (89%, n = 8) and severe disease (70.4%, n = 19) (p > 0.05), The mean iHS4 was reduced from 16.7 to 7.2 (p < 0.001).The time from HS onset to diagnosis was similar (6.7 years vs. 11.8; p = 0.282). At W24 the iHS4 reduction was significant (mean iHS4 = 6.5; (p < 0.001). At W52, the mean iHS4 was 4.7 (p < 0.001), and HISCR was still achieved in 76.7% (n = 23/30) of the patients. Between baseline and W52, DLQI and VAS pain shifted from a mean value of 15.4 to 10.5 (p = 0.001) and 4.4 to 1.8 (p < 0.001), respectively.

Within the first 16 weeks, in order to successfully control HS inflammatory activity, adjuvant, transitory, and medical treatments were employed in 72% (n = 26) of the cases. During the remaining period, adjuvant therapeutics were needed in 20 patients to control episodic flares.

Addressing the differences between patients staged as Hurley II and III (Table 2), 82% (n = 9) of male patients were classified as Hurley III, compared to 48% (n = 12) of females who presented such severity (p = 0.044). At baseline, Hurley II patients presented similar severity (mean iHS4: 13.7 vs. 18.8; p = 0.085) but with a significantlower number of draining fistulae (2.0 vs. 3.9; p = 0.002). While both groups recorded HS improvement under treatment, significantly better control of disease activity at W52 was observed within Hurley II patients (iHS4: 1.3 vs. 7; p = 0.003). Otherwise, the response to adalimumab measured by HISCR achievement at W16 and W52 was superior and similar in Hurley II patients (W16: 93% vs. 61.9%, p = 0.051; W52: 83.3% vs. 72.2%; p = 0.669), respectively.

Table 2.

Clinical characterization and therapeutic response of Hurley II and Hurley III HS groups.

  Hurley II  Hurley III  Statistical significance (p<0.05) 
Number of affected sites  3.1  3.9  0.121 
HS onset (years)a  29.1  26.7  0.595 
Diagnosis delay (years)a  6.7  8.9  0.508 
Initial iHS4 (n=36)a  13.7  18.9  0.085 
Initial number of draining fistulas (n=36)a  2.0  3.9  0.002 
W16 iHS4 (n=36)a  3.8  9.6  0.038 
W24 iHS4 (n=33)a,b  1.2  10.4  <0.001 
W52 iHS4 (n=30)a,c  1.3  0.003 
W52 number of draining fistulas (n=30)a,c  0.1  1.9  0.002 
W16 HISCR (n=36)a  93.3% (n=14)  61.9% (n=13)  0.051 
W52 HISCR (n=30)c  83.3% (n=10)  72.2% (n=13)  0.669 
W52 Adalimumab only (n=30)  41.7% (n=5)  27.8% (n=5)  0.461 
a

Data are reported as means.

b

n=33 ‒ two patients were evaluated only at W16 and one had adalimumab discontinued due to primary failure.

c

n=30 – two patients had their last evaluation at W24 and one had adalimumab discontinued due to secondary failure.

Considering the last clinical evaluation of all patients, 78% (n = 28) witnessed a reduction of at least 50% of their iHS4 at baseline (p < 0.001). Within the group that did not achieve such a response (n = 8), half presented with more than five draining fistulas at baseline and two of them switched biological treatment.

Clinical trials have shown that adalimumab is an effective treatment for moderate-to-severe HS with inadequate response to conventional treatments,6–8 with HISCR achievement rates ranging from 40%‒60% in monotherapy.4,6,8,9 The present study’s results showed superiority in terms of HISCR achievement at W12/16, W24 and W52 when compared to PIONEER I and II clinical trials and to Marzano et al. multicentre study.4,6–8 We associated the better results (75% HISCR achievers at W16) with the use of adjuvant intralesional and systemic therapeutics. This, we believe, may be a necessary practice in a real-life setting in order to further reduce inflammation and pain in notably severe cases along with adalimumab induction. Additionally, as flares can still be observed in patients on adalimumab monotherapy, adjuvant therapies may be required to treatment optimization.

The present results showed a greater response to adalimumab in Hurley II patients when compared to Hurley III, especially observable in the mean iHS4 reduction. Also, the delay to HS diagnosis was higher in the Hurley III group. These findings follow the trend within the “Window of Opportunity” hypothesis, which has postulated an inverse relationship between HS duration and/or diagnostic delay and adalimumab effectiveness.4,9,10 It has been suggested that starting adalimumab earlier, when HS is characterized by reversible lesions, encompasses the potential to prevent disease progression, development of fistulas, and permanent deformities.4,10 Hurley III patients enclose a more severe clinical status, which may justify lower effectiveness of adalimumab. The present findings further highlight the importance of precocious diagnosis, in order to effectively treat and prevent HS natural evolution.

In conclusion, adalimumab is a useful and effective treatment for HS although in monotherapy may not be sufficient to allow optimal control in some patients. This study supports the need for a proactive treatment, underlining the importance of early referral, the precocious use of adalimumab, and of the benefit of adjuvant therapies in patients under adalimumab. We highlight that real-life evidence is still scarce and more studies must be performed to allow more suitable evidence-based therapeutic guidelines.

Financial support

The authors received no financial support for the research, authorship, and/or publication of this article.

Authors’ contributions

José Miguel Neves: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic management of studied cases; manuscript critical review; preparation and writing of the manuscript; statistical analysis; study conception and planning.

Nélia Cunha: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic management of studied cases; manuscript critical review; preparation and writing of the manuscript; statistical analysis; study conception and planning.

André Lencastre: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic management of studied cases; manuscript critical review; preparation and writing of the manuscript; statistical analysis; study conception and planning.

Joana Cabete: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic management of studied cases; manuscript critical review; preparation and writing of the manuscript; statistical analysis; study conception and planning.

Conflicts of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Study conducted at the Department of Dermatology and Venereology, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

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