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along with environmental factors&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;4</span></a> Various genes of the immune system have been reported to contribute to the development of this disease&#44; such as the autoimmune regulator &#40;AIRE&#41; gene&#44; human leukocyte antigen &#40;HLA&#41;&#44; interleukin &#40;IL&#41; genes&#44; cytotoxic T lymphocyte-associated antigen 4 &#40;CTLA4&#41;&#44; protein tyrosine phosphatase non-receptor type 22 &#40;PTPN22&#41;&#44; tumor necrosis factor superfamily member 6 or CD95 &#40;FAS&#41; and FAS ligand &#40;FASL&#41; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The cytotoxic T-lymphocyte antigen 4 &#40;CTLA4&#41; gene &#40;2q34&#41; is a member of the immunoglobulin superfamily encoding a protein whose function is that of a potent negative regulator of T-cell response&#46; Also involved in the maintenance of immune tolerance&#44; it has been implicated as a susceptibility gene in human autoimmune diseases&#44; presenting several polymorphisms that have been associated with its development&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> Among the latter&#44; two genetic variants may contribute to AA susceptibility&#58; &#43;49AG &#40;rs231775&#41;&#44; a missense variation leading to a threonine to alanine aminoacid substitution at codon 17 in the leader peptide &#40;T17A&#41;&#59; and CT60 &#40;rs3087243&#41;&#44; located 236 bp downstream of CTLA4 gene &#40;3&#8242;-UTR&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> However&#44; recent studies conducted in different populations have shown that the relationship of these genetic variants in the development of AA is controversial&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The current study sought to determine whether the CTLA4 &#43;49AG &#40;rs231775&#41; 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The patients were recruited from the Dermatology Department after the acceptance and signature of an informed consent&#46; Ethical approval was given by the Institutional Review Board and this study was registered under the code DE09-001&#46; Further details regarding the clinical and demographic characteristics&#44; AA type and distribution of each patient were obtained during the clinical evaluation&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">DNA isolation and genotyping</span><p id="par0025" class="elsevierStylePara elsevierViewall">Genomic DNA was isolated from peripheral venous blood using a &#8220;salting-out&#8221; method and suspended in Tris&#8211;EDTA &#40;pH 7&#46;8&#41; at a final concentration 0&#46;1&#8211;1&#46;0<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;&#956;L before use&#46; Genotype and allele frequencies of the CTLA4 &#43;49AG &#40;rs231775&#41; andCT60 &#40;rs3087243&#41; gene variants were characterized by PCR-RFLP using a MJ Mini PTC1148 thermal cycler &#40;Bio-Rad&#44; Hercules&#59; CA&#44; USA&#41;&#44; specific oligonucleotide primers &#40;IDT&#44; Coralville&#44; IA&#44; USA&#41; and restriction enzymes &#40;New England Biolabs&#44; Ipswich&#44; MA&#44; USA&#41; according to a previously published protocol&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> The fragments obtained were analyzed by electrophoresis in a 2&#46;5&#37; agarose gel containing ethidium bromide&#44; visualized in UVP model 2UV High Performance Transilluminator &#40;Upland&#44; CA&#44; USA&#41; and documented&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Statistical analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">For genetic analysis&#44; the sample size was calculated based on 2&#37; worldwide alopecia areata incidence&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> assuming a power of 99&#46;0&#37; &#40;a <span class="elsevierStyleItalic">Z</span> value of 2&#46;33&#41;&#44; a minimum number of 43 subjects is sufficient&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Data analysis was performed with the SPSS v21&#46;0 software for windows &#40;SPSS&#44; Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41; and the Epi-INFO TM 7 statistical program &#40;Stone&#46; Mountain&#44; GA&#44; USD Inc&#41;&#46; Hardy&#8211;Weinberg equilibrium for the alleles was obtained using a goodness-of-fit test and the genotypic dependence between patients and controls was determined with a <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test&#59; OR was calculated from 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2 contingency tables &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Results</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Clinical characteristics of the participants</span><p id="par0040" class="elsevierStylePara elsevierViewall">The present study analyzed the genotype distribution and allele frequency of CTLA4 &#43;49AG and CT60 gene variants&#46; Our universe &#40;<span class="elsevierStyleItalic">n</span>&#41; consisted of 50 AA patients and 100 control participants&#46; The clinical presentation of AA in the patients was&#58; 41 Patchy AA subjects &#40;single patch <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#44; 8 females and 6 males&#59; multiple patches <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44; 19 females and 8 males&#41;&#44; 4 Ophiasis AA subjects &#40;3 females and 1 male&#41;&#44; 1 female with Totalis AA and 4 Universalis AA subjects &#40;3 males and 1 female&#41;&#46; Ten patients &#40;20&#37;&#41; had a personal history of autoimmune diseases &#40;Vitiligo&#44; type 2 DM&#44; among others&#41; and 36 subjects &#40;72&#37;&#41; have family history of immune disease&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Allele and genotype analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">Several tests were performed for both genetic variants in order to assess the Hardy&#8211;Weinberg equilibrium &#40;HWE&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; all of which had a <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; indicating that rs231775 and rs3087243 gene variants were in HWE in both AA patients and controls&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">We compared the CTLA4 rs231775 and the rs3087243 alleles and genotypes of the control group with AA subjects &#40;all AA types&#41;&#44; and with the different types of AA&#44; detailed results are shown in <a class="elsevierStyleCrossRef" href="#tbl0005"><span class="elsevierStyleBold">table 1</span></a>&#46; For CTLA4 rs231775&#44; 30&#37; of AA patients showed an homozygous wild type AA genotype&#44; 48&#37; showed the heterozygous AG genotype&#44; and the remaining 22&#37; were variant homozygous GG genotype&#46; For CTLA4 rs3087243&#44; 44&#37; of the AA patients showed the homozygous wild type GG genotype&#44; 44&#37; showed the heterozygous AG genotype and the remaining 12&#37; were variant homozygous AA genotype&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Association of the genotypes in patients con alopecia areata</span><p id="par0055" class="elsevierStylePara elsevierViewall">When CTLA4 rs231775 and rs3087243 genotypes and allele frequencies were compared between the whole cohort &#40;all AA types&#41; and controls&#44; we observed that the heterozygous AG genotype for CTLA4 rs231775 and rs3087243 was more frequent in controls than across all AA patient groups&#46; Further&#44; no evidence was observed concerning the association of the allele variants and AA in the analyzed patients &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Furthermore&#44; no relationship was found between genotype and type of AA with the personal&#47;familiar history of autoimmune diseases or the sex of the analyzed patients &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">AA is an autoimmune hair-loss condition that has been associated with multiple gene variants&#44; several of which participate in immune response pathways related to HLA&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> The CTLA4 gene product is a receptor expressed by CD4&#43; and CD8&#43; T-cells&#46; Experiments in knockout mice have demonstrated the important role that CTLA4 plays in protection against autoimmunity&#46; CTLA-4 is a critical negative regulator of T cell responses&#44; and the action of CTLA4 on Treg cells can control the activity of other cells and controlling fatal autoimmunity&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The association between the presence of the CTLA4 gene variants and the development of different autoimmune diseases has been suggested&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#44;15</span></a> However in immune dermatological diseases&#44; the results have been controversial&#59; in vitiligo their participation or lack of influence<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> has been seen&#46; A similar situation has been observed with the development of psoriasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In this regard&#44; considering the possible contribution of the autoimmune function in alopecia&#44; genetic variant studies of CTLA4 gene have been explored in diverse populations&#46; A previous association analysis has suggested the plausible involvement of CTLA4 gene variants as a risk factor in the development of AA in a European population&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> with a stronger effect in patients with severe forms of the disorder&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Another study conducted on an Italian population&#44; where rs231775 and rs3087243 gene variants were analyzed&#44; observed the latter as a risk factor in the development of patchy AA&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> On the other hand&#44; a study conducted on Iran nationals failed to prove the association of the rs3087243 gene variant in the development of AA&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Previously&#44; we observed the participation of genetic variants of TNF&#945; and PTPN22<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> as a risk factor for AA in Mexican patients&#59; both of these genes&#8217; function is related to the regulation of immune mechanisms&#46; However&#44; the participation of CTLA4 genetic variants in AA has not been analyzed in this population&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Some SNPs within the CTLA-4 gene have already been analyzed for susceptibility to rheumatoid arthritis &#40;RA&#41; in the Mexican population&#59; among them&#44; rs5742909&#44; rs231775 and rs3087243&#44; suggesting that the &#8722;319C&#47;&#43;49G&#47;CT60G haplotype of the CTLA-4 gene is a risk factor for RA&#44; whereas that the rs3087243 SNP could be a protective factor against this type of autoimmune disease&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">However&#44; no significant differences were observed for rs231775 and rs3087243 in our study population &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#44; suggesting that these variants are not a risk factor in the development of AA or Patchy AA in the Mexican population&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">In conclusion&#44; the genetic variants rs231775 and rs3087243 of the CTLA4 gene do not constitute a risk factor in the development of AA in the Mexican population of Monterrey&#44; Mexico&#46; Further&#44; these genetic variants have no association between family&#47;personal backgrounds of autoimmune diseases or the gender of the study subjects&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financial support</span><p id="par0100" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Authors&#39; contributions</span><p id="par0105" class="elsevierStylePara elsevierViewall">Mauricio Andr&#233;s Salinas Santander&#58; Statistic analysis&#59; approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; effective participation in research orientation&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Cristina Susana Cantu-Salinas&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; effective participation in research orientation&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Jorge Ocampo-Candiani&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; effective participation in research orientation&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Victor de Jesus Suarez-Valencia&#58; Approval of the final version of the manuscript&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Jennifer Guadalupe Ramirez-Guerrero&#58; Approval of the final version of the manuscript&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the literature&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Celia Nohemi Sanchez-Dominguez&#58; Approval of the final version of the manuscript&#59; elaboration and writing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicts of interest</span><p id="par0135" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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    "fechaRecibido" => "2019-06-06"
    "fechaAceptado" => "2019-09-24"
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            0 => "Alopecia areata"
            1 => "Autoimmune diseases"
            2 => "Polymorphism"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body&#46; Gene variants of the cytotoxic T-lymphocyte antigen 4 &#40;CTLA4&#41; gene&#44; a negative regulator of T-cell response&#44; have been associated with a predisposition to autoimmune diseases in different populations&#59; however&#44; the involvement of these genetic variants in the development of AA is controversial&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We genotyped &#43;49AG &#40;rs231775&#41; and CT60 &#40;rs3087243&#41; variants in 50 AA patients and 100 healthy control participants through PCR-RFLP&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family&#47;personal history of autoimmune diseases or gender were considered &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; <span class="elsevierStyleItalic">Study limitations&#58;</span> Small sample size of patients and the data were obtained from Northeast Mexico population&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factor for the development of alopecia areata in the analyzed Mexican population&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Salinas-Santander MA&#44; Cantu-Salinas CS&#44; Ocampo-Candiani J&#44; Suarez-Valencia VJ&#44; Ramirez-Guerrero JG&#44; Sanchez-Dominguez CN&#46; CTLA4 &#43;49AG &#40;rs231775&#41; and CT60 &#40;rs3087243&#41; gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico&#46; An Bras Dermatol&#46; 2020&#59;95&#58;283&#8211;8&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Department of Investigation&#44; Facultad de Medicina Unidad Saltillo&#44; Universidad Aut&#243;noma de Coahuila&#44; Coahuila&#44; M&#233;xico&#44; and Dermatology Service&#44; Hospital Universitario Dr&#46; Jos&#233; Eleuterio Gonz&#225;lez&#44; Facultad de Medicina&#44; Universidad Aut&#243;noma de Nuevo Le&#243;n&#44; Nuevo Le&#243;n&#44; M&#233;xico&#46;</p>"
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Analysis of the gene variants CTLA4 &#43;49AG &#40;rs231775&#41; and CT60 &#40;rs3087243&#41; frequencies with the sex and personal&#47;familiar history of autoimmune diseases&#46;</p>"
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                    0 => array:2 [
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                            0 => "T&#46; Simakou"
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                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
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              "identificador" => "bib0110"
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                0 => array:2 [
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                    0 => array:2 [
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                        "tituloSerie" => "Clin Rev Allergy Immunol"
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                        "paginaInicial" => "68"
                        "paginaFinal" => "87"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28717940"
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                          ]
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                    ]
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                    0 => array:2 [
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                        "paginaInicial" => "666"
                        "paginaFinal" => "679"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29979892"
                            "web" => "Medline"
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                        "tituloSerie" => "Indian J Dermatol"
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                        "link" => array:1 [
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                      "titulo" => "CTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in northern Chinese population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Sun"
                            1 => "Y&#46; Meng"
                            2 => "Y&#46; Xie"
                            3 => "H&#46; Zhang"
                            4 => "Z&#46; Zhang"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0101986"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLOS ONE"
                        "fecha" => "2014"
                        "volumen" => "9"
                        "paginaInicial" => "e101986"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25003519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and burden of alopecia areata&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;C&#46; Villasante Fricke"
                            1 => "M&#46; Miteva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/CCID.S53985"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cosmet Investig Dermatol"
                        "fecha" => "2015"
                        "volumen" => "8"
                        "paginaInicial" => "397"
                        "paginaFinal" => "403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26244028"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Betz"
                            1 => "L&#46; Petukhova"
                            2 => "S&#46; Ripke"
                            3 => "H&#46; Huang"
                            4 => "A&#46; Menelaou"
                            5 => "S&#46; Redler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ncomms6966"
                      "Revista" => array:5 [
                        "tituloSerie" => "Nat Commun"
                        "fecha" => "2015"
                        "volumen" => "6"
                        "paginaInicial" => "5966"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25608926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA-4&#58; a moving target in immunotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Rowshanravan"
                            1 => "N&#46; Halliday"
                            2 => "D&#46;M&#46; Sansom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2017-06-741033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2018"
                        "volumen" => "131"
                        "paginaInicial" => "58"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29118008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA-4 &#43;49 G&#47;A polymorphism confers autoimmune disease risk&#58; an updated meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Wang"
                            1 => "Q&#46; Zhu"
                            2 => "Y&#46; Lu"
                            3 => "H&#46; Lu"
                            4 => "F&#46; Zhang"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/gtmb.2016.0335"
                      "Revista" => array:6 [
                        "tituloSerie" => "Genet Test Mol Biomarkers"
                        "fecha" => "2017"
                        "volumen" => "21"
                        "paginaInicial" => "222"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28384040"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of cytotoxic T-lymphocyte-associated protein 4 &#40;CTLA4&#41; gene polymorphisms with autoimmune thyroid disease in children and adults&#58; case&#8211;control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;H&#46; Ting"
                            1 => "M&#46;N&#46; Chien"
                            2 => "F&#46;S&#46; Lo"
                            3 => "C&#46;H&#46; Wang"
                            4 => "C&#46;Y&#46; Huang"
                            5 => "C&#46;L&#46; Lin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0154394"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLOS ONE"
                        "fecha" => "2016"
                        "volumen" => "11"
                        "paginaInicial" => "e0154394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27111218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Deeba"
                            1 => "R&#46; Syed"
                            2 => "J&#46; Quareen"
                            3 => "M&#46;A&#46; Waheed"
                            4 => "K&#46; Jamil"
                            5 => "H&#46; Rao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0019-5154.60347"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Dermatol"
                        "fecha" => "2010"
                        "volumen" => "55"
                        "paginaInicial" => "29"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20418973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between cytotoxic T-lymphocyte antigen-4&#43;49A&#47;G polymorphism and psoriasis and vitiligo&#58; a meta-analysis of case&#8211;control studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Liang"
                            1 => "S&#46; Zhang"
                            2 => "Q&#46; Luo"
                            3 => "W&#46; Li"
                            4 => "X&#46; Tian"
                            5 => "F&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.gene.2015.05.051"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gene"
                        "fecha" => "2015"
                        "volumen" => "568"
                        "paginaInicial" => "196"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26013045"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with psoriasis vulgaris&#58; a case&#8211;control study in Turkish population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46;G&#46; Dursun"
                            1 => "H&#46;O&#46; Yilmaz"
                            2 => "R&#46; Dursun"
                            3 => "S&#46; Kulaksizoglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2018/1643906"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol Res"
                        "fecha" => "2018"
                        "volumen" => "2018"
                        "paginaInicial" => "1643906"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29850619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between PTPN22 C1858T polymorphism and alopecia areata risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Salinas-Santander"
                            1 => "C&#46; Sanchez-Dominguez"
                            2 => "C&#46; Cantu-Salinas"
                            3 => "H&#46; Gonzalez-Cardenas"
                            4 => "A&#46;C&#46; Cepeda-Nieto"
                            5 => "R&#46;M&#46; Cerda-Flores"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3892/etm.2015.2728"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Ther Med"
                        "fecha" => "2015"
                        "volumen" => "10"
                        "paginaInicial" => "1953"
                        "paginaFinal" => "1958"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26640579"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "The &#8722;319C&#47;&#43;49G&#47;CT60G haplotype of CTLA-4 gene confers susceptibility to rheumatoid arthritis in Mexican population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Torres-Carrillo"
                            1 => "H&#46; Ontiveros-Mercado"
                            2 => "N&#46;M&#46; Torres-Carrillo"
                            3 => "I&#46; Parra-Rojas"
                            4 => "H&#46; Rangel-Villalobos"
                            5 => "M&#46;G&#46; Ramirez-Duenas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12013-013-9640-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Biochem Biophys"
                        "fecha" => "2013"
                        "volumen" => "67"
                        "paginaInicial" => "1217"
                        "paginaFinal" => "1228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23703660"
                            "web" => "Medline"
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Journal Information
Vol. 95. Issue 3.
Pages 283-288 (1 May 2020)
Visits
6065
Vol. 95. Issue 3.
Pages 283-288 (1 May 2020)
Investigation
Open Access
CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico
Visits
6065
Mauricio Andrés Salinas-Santandera,
Corresponding author
msalinsa@yahoo.com

Corresponding author.
, Cristina Susana Cantu-Salinasb, Jorge Ocampo-Candianib, Victor de Jesus Suarez-Valenciaa, Jennifer Guadalupe Ramirez-Guerreroa, Celia Nohemi Sanchez-Dominguezc
a Department of Investigation, Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico
b Dermatology Service, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico
c Department of Biochemistry and Molecular Medicine, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, Mexico
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Abstract
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Tables (3)
Table 1. Tests for deviation from Hardy–Weinberg equilibrium in AA patients and healthy controls.
Table 2. Allele and genotype frequency of the gene variants CTLA4 +49AG (rs231775) and CT60 (rs3087243) in AA patients and healthy controls.
Table 3. Analysis of the gene variants CTLA4 +49AG (rs231775) and CT60 (rs3087243) frequencies with the sex and personal/familiar history of autoimmune diseases.
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Abstract
Background

Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial.

Objective

The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population.

Methods

We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP.

Results

No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p>0.05). Study limitations: Small sample size of patients and the data were obtained from Northeast Mexico population.

Conclusion

The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factor for the development of alopecia areata in the analyzed Mexican population.

Keywords:
Alopecia areata
Autoimmune diseases
Polymorphism
Single nucleotide
Full Text
Introduction

Alopecia areata (AA) is an autoimmune disease that produces non-scarring hair loss through the body at any age.1 AA is commonly presented as single or multiple rounded patches, although complete baldness may occur, which is called AA totalis. If the hair loss occurs throughout the body is known as AA universalis. AA can also be presented as in the circumference of the head and is known as AA ophis.2 AA is considered a polygenic disease influenced by a genetically complex inheritance, especially of autoimmune and inflammatory related genes, along with environmental factors.3,4 Various genes of the immune system have been reported to contribute to the development of this disease, such as the autoimmune regulator (AIRE) gene, human leukocyte antigen (HLA), interleukin (IL) genes, cytotoxic T lymphocyte-associated antigen 4 (CTLA4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), tumor necrosis factor superfamily member 6 or CD95 (FAS) and FAS ligand (FASL) among others.5,6

The cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (2q34) is a member of the immunoglobulin superfamily encoding a protein whose function is that of a potent negative regulator of T-cell response. Also involved in the maintenance of immune tolerance, it has been implicated as a susceptibility gene in human autoimmune diseases, presenting several polymorphisms that have been associated with its development.7 Among the latter, two genetic variants may contribute to AA susceptibility: +49AG (rs231775), a missense variation leading to a threonine to alanine aminoacid substitution at codon 17 in the leader peptide (T17A); and CT60 (rs3087243), located 236 bp downstream of CTLA4 gene (3′-UTR).8 However, recent studies conducted in different populations have shown that the relationship of these genetic variants in the development of AA is controversial.3,9

The current study sought to determine whether the CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants constitute a predisposition factor for AA in a cohort of Mexican patients.

MethodsSelection of subjects and controls

The study included 50 unrelated Mexican subjects diagnosed with AA (32 females and 18 males; 30±15 years old on average) and 100 healthy control participants (59 females and 41 males; 25±8 years old on average), the latter showed a negative medical family history for autoimmune/inflammatory diseases. The patients were recruited from the Dermatology Department after the acceptance and signature of an informed consent. Ethical approval was given by the Institutional Review Board and this study was registered under the code DE09-001. Further details regarding the clinical and demographic characteristics, AA type and distribution of each patient were obtained during the clinical evaluation.

DNA isolation and genotyping

Genomic DNA was isolated from peripheral venous blood using a “salting-out” method and suspended in Tris–EDTA (pH 7.8) at a final concentration 0.1–1.0μg/μL before use. Genotype and allele frequencies of the CTLA4 +49AG (rs231775) andCT60 (rs3087243) gene variants were characterized by PCR-RFLP using a MJ Mini PTC1148 thermal cycler (Bio-Rad, Hercules; CA, USA), specific oligonucleotide primers (IDT, Coralville, IA, USA) and restriction enzymes (New England Biolabs, Ipswich, MA, USA) according to a previously published protocol.10 The fragments obtained were analyzed by electrophoresis in a 2.5% agarose gel containing ethidium bromide, visualized in UVP model 2UV High Performance Transilluminator (Upland, CA, USA) and documented.

Statistical analysis

For genetic analysis, the sample size was calculated based on 2% worldwide alopecia areata incidence,11 assuming a power of 99.0% (a Z value of 2.33), a minimum number of 43 subjects is sufficient.

Data analysis was performed with the SPSS v21.0 software for windows (SPSS, Inc., Chicago, IL, USA) and the Epi-INFO TM 7 statistical program (Stone. Mountain, GA, USD Inc). Hardy–Weinberg equilibrium for the alleles was obtained using a goodness-of-fit test and the genotypic dependence between patients and controls was determined with a χ2 test; OR was calculated from 2×2 contingency tables (p<0.05).

ResultsClinical characteristics of the participants

The present study analyzed the genotype distribution and allele frequency of CTLA4 +49AG and CT60 gene variants. Our universe (n) consisted of 50 AA patients and 100 control participants. The clinical presentation of AA in the patients was: 41 Patchy AA subjects (single patch n=14, 8 females and 6 males; multiple patches n=27, 19 females and 8 males), 4 Ophiasis AA subjects (3 females and 1 male), 1 female with Totalis AA and 4 Universalis AA subjects (3 males and 1 female). Ten patients (20%) had a personal history of autoimmune diseases (Vitiligo, type 2 DM, among others) and 36 subjects (72%) have family history of immune disease.

Allele and genotype analysis

Several tests were performed for both genetic variants in order to assess the Hardy–Weinberg equilibrium (HWE) (Table 1) all of which had a p>0.05, indicating that rs231775 and rs3087243 gene variants were in HWE in both AA patients and controls.

Table 1.

Tests for deviation from Hardy–Weinberg equilibrium in AA patients and healthy controls.

SNP/HWE test  AA cases (p-value)  Controls (p-value) 
rs231775
Pearson  0.81  0.88 
Likelihood-ratio  0.81  0.88 
Fisher exact  0.78  1.00 
rs3087243
Pearson  0.89  0.50 
Likelihood-ratio  0.89  0.50 
Fisher exact  1.00  0.54 

We compared the CTLA4 rs231775 and the rs3087243 alleles and genotypes of the control group with AA subjects (all AA types), and with the different types of AA, detailed results are shown in table 1. For CTLA4 rs231775, 30% of AA patients showed an homozygous wild type AA genotype, 48% showed the heterozygous AG genotype, and the remaining 22% were variant homozygous GG genotype. For CTLA4 rs3087243, 44% of the AA patients showed the homozygous wild type GG genotype, 44% showed the heterozygous AG genotype and the remaining 12% were variant homozygous AA genotype.

Association of the genotypes in patients con alopecia areata

When CTLA4 rs231775 and rs3087243 genotypes and allele frequencies were compared between the whole cohort (all AA types) and controls, we observed that the heterozygous AG genotype for CTLA4 rs231775 and rs3087243 was more frequent in controls than across all AA patient groups. Further, no evidence was observed concerning the association of the allele variants and AA in the analyzed patients (p>0.05) (Table 2). Furthermore, no relationship was found between genotype and type of AA with the personal/familiar history of autoimmune diseases or the sex of the analyzed patients (p>0.05) (Table 3).

Table 2.

Allele and genotype frequency of the gene variants CTLA4 +49AG (rs231775) and CT60 (rs3087243) in AA patients and healthy controls.

Genotype  AA patients no. (%)  Controls no. (%)  χ2  OR  95% CI  p-Value 
All AA types  rs231775           
AA  15 (30)  28 (28.3)  0.086      0.958 
AG  24 (48)  50 (50.5)         
GG  11 (22)  21 (21.2)         
AG+GG  24 (48)+11 (22)  50 (50.5)+21 (21.2)  0.048  1.087  0.515–2.292  0.827 
Alleles
54 (54)  106 (53.5)  0.006  1.019  0.629–1.650  0.939 
46 (46)  92 (46.5)  0.006  0.982  0.606–1.590  0.939 
Patchy AA
AA  13 (31.7)  28 (28.3)  0.225      0.893 
AG  19 (46.3)  50 (50.5)         
GG  9 (22)  21 (21.2)         
AG+GG  19 (46.3)+9 (22)  50 (50.5)+21 (21.2)  0.164  1.177  0.534–2.594  0.685 
Alleles
45 (54.9)  106 (53.5)  0.042  1.056  0.630–1.770  0.837 
37 (45.1)  92 (46.5)  0.042  0.947  0.565–1.589  0.837 
Multiple patch AA
AA  11 (40.7)  28 (28.3)  1.66      0.436 
AG  12 (44.5)  50 (50.5)         
GG  4 (14.8)  21 (21.2)         
AG+GG  12 (44.5)+4 (14.8)  50 (50.5)+21 (21.2)  1.541  1.743  0.721–4.218  0.215 
Alleles
34 (63)  106 (53.5)  1.527  1.476  0.795–2.740  0.217 
20 (37)  92 (46.5)  1.527  0.678  0.365–1.259  0.217 
All AA types  rs3087243           
AA  6 (12)  16 (16)  2.129      0.345 
AG  22 (44)  52 (52)         
GG  22 (44)  32 (32)         
AG+GG  22 (44)+22 (44)  52 (52)+32 (32)  0.426  0.716  0.262–1.959  0.514 
Alleles
34 (34)  84 (42)  1.788  0.711  0.432–1.173  0.181 
66 (66)  116 (58)  1.788  1.406  0.853–2.318  0.181 
Patchy AA
AA  6 (14.6)  16 (16)  1.168      0.558 
AG  18 (43.9)  52 (52)         
GG  17 (41.5)  32 (32)         
AG+GG  18 (43.9)+17 (41.5)  52 (52)+32 (32)  0.041  0.9  0.325–2.49  0.839 
Alleles
30 (36.6)  84 (42)  0.708  0.797  0.469–1.353  0.4 
52 (63.4)  116 (58)  0.708  1.255  0.739–2.132  0.4 
Multiple patch AA
AA  4 (14.8)  16 (16)  0.031      0.985 
AG  14 (51.9)  52 (52)         
GG  9 (33.3)  32 (32)         
AG+GG  14 (51.9)+9 (33.3)  52 (52)+32 (32)  0.023  0.913  0.278–2.998  0.881 
Alleles
22 (40.7)  84 (42)  0.028  0.949  0.515–1.749  0.868 
32 (59.3)  116 (58)  0.028  1.053  0.572–1.941  0.868 
Table 3.

Analysis of the gene variants CTLA4 +49AG (rs231775) and CT60 (rs3087243) frequencies with the sex and personal/familiar history of autoimmune diseases.

  AA  AG  GG  p-Value  AA  AG  GG  p-Value 
Sex
Female (%)  8 (25%)  16 (50%)  8 (25%)  0.555  4 (12.5%)  14 (43.75%)  14 (43.75%)  0.990 
Male (%)  7 (38.9%)  8 (44.4%)  3 (16.7%)    2 (11.2%)  8 (44.4%)  8 (44.4%)   
Personal history of autoimmune diseases
Yes (%)  3 (30%)  3 (30%)  4 (40%)  0.261  1 (10%)  3 (30%)  6 (60%)  0.515 
No (%)  12 (30%)  21 (52.5%)  7 (17.5%)    5 (12.5%)  19 (47.5%)  16 (40%)   
Familiar history of autoimmune diseases
Yes (%)  10 (27.8%)  19 (52.8%)  7 (19.4%)  0.548  4 (11.1%)  17 (47.2%)  15 (41.7%)  0.761 
No (%)  5 (38.4%)  4 (30.8%)  4 (30.8%)    2 (14.3%)  5 (35.7%)  7 (50%)   
Discussion

AA is an autoimmune hair-loss condition that has been associated with multiple gene variants, several of which participate in immune response pathways related to HLA.12 The CTLA4 gene product is a receptor expressed by CD4+ and CD8+ T-cells. Experiments in knockout mice have demonstrated the important role that CTLA4 plays in protection against autoimmunity. CTLA-4 is a critical negative regulator of T cell responses, and the action of CTLA4 on Treg cells can control the activity of other cells and controlling fatal autoimmunity.13

The association between the presence of the CTLA4 gene variants and the development of different autoimmune diseases has been suggested.14,15 However in immune dermatological diseases, the results have been controversial; in vitiligo their participation or lack of influence16 has been seen. A similar situation has been observed with the development of psoriasis.17,18

In this regard, considering the possible contribution of the autoimmune function in alopecia, genetic variant studies of CTLA4 gene have been explored in diverse populations. A previous association analysis has suggested the plausible involvement of CTLA4 gene variants as a risk factor in the development of AA in a European population,8 with a stronger effect in patients with severe forms of the disorder.

Another study conducted on an Italian population, where rs231775 and rs3087243 gene variants were analyzed, observed the latter as a risk factor in the development of patchy AA.9 On the other hand, a study conducted on Iran nationals failed to prove the association of the rs3087243 gene variant in the development of AA.3

Previously, we observed the participation of genetic variants of TNFα and PTPN2219 as a risk factor for AA in Mexican patients; both of these genes’ function is related to the regulation of immune mechanisms. However, the participation of CTLA4 genetic variants in AA has not been analyzed in this population.

Some SNPs within the CTLA-4 gene have already been analyzed for susceptibility to rheumatoid arthritis (RA) in the Mexican population; among them, rs5742909, rs231775 and rs3087243, suggesting that the −319C/+49G/CT60G haplotype of the CTLA-4 gene is a risk factor for RA, whereas that the rs3087243 SNP could be a protective factor against this type of autoimmune disease.20

However, no significant differences were observed for rs231775 and rs3087243 in our study population (Table 2), suggesting that these variants are not a risk factor in the development of AA or Patchy AA in the Mexican population.

Conclusion

In conclusion, the genetic variants rs231775 and rs3087243 of the CTLA4 gene do not constitute a risk factor in the development of AA in the Mexican population of Monterrey, Mexico. Further, these genetic variants have no association between family/personal backgrounds of autoimmune diseases or the gender of the study subjects.

Financial support

None declared.

Authors' contributions

Mauricio Andrés Salinas Santander: Statistic analysis; approval of the final version of the manuscript; conception and planning of the study; elaboration and writing of the manuscript; obtaining, analysis, and interpretation of the data; effective participation in research orientation; critical review of the literature; critical review of the manuscript.

Cristina Susana Cantu-Salinas: Approval of the final version of the manuscript; conception and planning of the study; elaboration and writing of the manuscript; obtaining, analysis, and interpretation of the data; effective participation in research orientation; critical review of the literature; critical review of the manuscript.

Jorge Ocampo-Candiani: Approval of the final version of the manuscript; conception and planning of the study; effective participation in research orientation; critical review of the literature; critical review of the manuscript.

Victor de Jesus Suarez-Valencia: Approval of the final version of the manuscript; elaboration and writing of the manuscript; obtaining, analysis, and interpretation of the data; critical review of the literature; critical review of the manuscript.

Jennifer Guadalupe Ramirez-Guerrero: Approval of the final version of the manuscript; elaboration and writing of the manuscript; obtaining, analysis, and interpretation of the data; critical review of the literature.

Celia Nohemi Sanchez-Dominguez: Approval of the final version of the manuscript; elaboration and writing of the manuscript; critical review of the literature; critical review of the manuscript.

Conflicts of interest

None declared.

Acknowledgment

Thanks to Daniel Díaz, Ph.D. for his assistance in proofreading this manuscript.

References
[1]
T. Simakou, J.P. Butcher, S. Reid, F.L. Henriquez.
Alopecia areata: a multifactorial autoimmune condition.
J Autoimmun, 98 (2019), pp. 74-85
[2]
R.M. Trüeb, M.F.R.G. Dias.
Alopecia areata: a comprehensive review of pathogenesis and management.
Clin Rev Allergy Immunol, 54 (2018), pp. 68-87
[3]
H. Moravvej, P.S. Tabatabaei-Panah, R. Abgoon, L. Khaksar, M. Sokhandan, S. Tarshaei, et al.
Genetic variant association of PTPN22, CTLA4, IL2RA, as well as HLA frequencies in susceptibility to alopecia areata.
Immunol Invest, 47 (2018), pp. 666-679
[4]
Z. Zhang, X. Wang, R. Zhang.
Pathogenesis of alopecia areata based on bioinformatics analysis.
Indian J Dermatol, 64 (2019), pp. 1-6
[5]
F. Rajabi, L.A. Drake, M.M. Senna, N. Rezaei.
Alopecia areata: a review of disease pathogenesis.
Br J Dermatol, 179 (2018), pp. 1033-1048
[6]
I. Seleit, O.A. Bakry, E.A.E. Gayed, A.E.D. Gawad.
Polymorphism of FAS and FAS ligand genes in alopecia areata: a case-control study in Egyptian population.
Indian J Dermatol, 63 (2018), pp. 220-226
[7]
A.M. Paterson, S.B. Lovitch, P.T. Sage, V.R. Juneja, Y. Lee, J.D. Trombley, et al.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
J Exp Med, 212 (2015), pp. 1603-1621
[8]
K.K. John, F.F. Brockschmidt, S. Redler, C. Herold, S. Hanneken, S. Eigelshoven, et al.
Genetic variants in CTLA4 are strongly associated with alopecia areata.
J Invest Dermatol, 131 (2011), pp. 1169-1172
[9]
F. Megiorni, B. Mora, C. Maxia, M. Gerardi, A. Pizzuti, A. Rossi.
Cytotoxic T-lymphocyte antigen 4 (CTLA4) +49AG and CT60 gene polymorphisms in alopecia areata: a case–control association study in the Italian population.
Arch Dermatol Res, 305 (2013), pp. 665-670
[10]
L. Sun, Y. Meng, Y. Xie, H. Zhang, Z. Zhang, X. Wang, et al.
CTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in northern Chinese population.
[11]
A.C. Villasante Fricke, M. Miteva.
Epidemiology and burden of alopecia areata: a systematic review.
Clin Cosmet Investig Dermatol, 8 (2015), pp. 397-403
[12]
R.C. Betz, L. Petukhova, S. Ripke, H. Huang, A. Menelaou, S. Redler, et al.
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
Nat Commun, 6 (2015), pp. 5966
[13]
B. Rowshanravan, N. Halliday, D.M. Sansom.
CTLA-4: a moving target in immunotherapy.
[14]
K. Wang, Q. Zhu, Y. Lu, H. Lu, F. Zhang, X. Wang, et al.
CTLA-4 +49 G/A polymorphism confers autoimmune disease risk: an updated meta-analysis.
Genet Test Mol Biomarkers, 21 (2017), pp. 222-227
[15]
W.H. Ting, M.N. Chien, F.S. Lo, C.H. Wang, C.Y. Huang, C.L. Lin, et al.
Association of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene polymorphisms with autoimmune thyroid disease in children and adults: case–control study.
PLOS ONE, 11 (2016), pp. e0154394
[16]
F. Deeba, R. Syed, J. Quareen, M.A. Waheed, K. Jamil, H. Rao.
CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population.
Indian J Dermatol, 55 (2010), pp. 29-32
[17]
J. Liang, S. Zhang, Q. Luo, W. Li, X. Tian, F. Zhang, et al.
Lack of association between cytotoxic T-lymphocyte antigen-4+49A/G polymorphism and psoriasis and vitiligo: a meta-analysis of case–control studies.
[18]
H.G. Dursun, H.O. Yilmaz, R. Dursun, S. Kulaksizoglu.
Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with psoriasis vulgaris: a case–control study in Turkish population.
J Immunol Res, 2018 (2018), pp. 1643906
[19]
M. Salinas-Santander, C. Sanchez-Dominguez, C. Cantu-Salinas, H. Gonzalez-Cardenas, A.C. Cepeda-Nieto, R.M. Cerda-Flores, et al.
Association between PTPN22 C1858T polymorphism and alopecia areata risk.
Exp Ther Med, 10 (2015), pp. 1953-1958
[20]
N. Torres-Carrillo, H. Ontiveros-Mercado, N.M. Torres-Carrillo, I. Parra-Rojas, H. Rangel-Villalobos, M.G. Ramirez-Duenas, et al.
The −319C/+49G/CT60G haplotype of CTLA-4 gene confers susceptibility to rheumatoid arthritis in Mexican population.
Cell Biochem Biophys, 67 (2013), pp. 1217-1228

How to cite this article: Salinas-Santander MA, Cantu-Salinas CS, Ocampo-Candiani J, Suarez-Valencia VJ, Ramirez-Guerrero JG, Sanchez-Dominguez CN. CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico. An Bras Dermatol. 2020;95:283–8.

Study conducted at the Department of Investigation, Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Coahuila, México, and Dermatology Service, Hospital Universitario Dr. José Eleuterio González, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.

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