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L&#46;N&#46;B&#44; JAAI&#44; BLM&#44; ERL&#41;&#46; Previous experience on dermoscopy was &#62;10 years &#40;1 observer&#41;&#44; &#62;5 years &#40;2 observers&#41;&#44; and &#60;5 years &#40;2 observers&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A retrospective evaluation of dermoscopic images collected from the database of the Melanoma Unit in our department was performed&#46; Images were obtained using a digital polarized dermoscopy system &#40;Dermlite Photo II Pro HR&#174; &#91;3Gen&#174;&#44; San Juan Capistrano&#44; CA&#44; USA&#93; and an Olympus E-420&#174; camera &#91;Olympus&#44; Tokyo&#44; Japan&#93;&#41;&#46; Lesion diameter had to fit in the picture to be included&#46; Cases without histopathological confirmation&#44; melanoma metastases&#44; or melanomas of special sites &#40;facial&#44; acral&#44; nail&#44; genital&#44; or mucosal melanoma&#41; were excluded&#46; The distribution of diagnosis in our sample is shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The following dermoscopic features were analyzed&#58; colors &#40;light brown&#44; dark brown&#44; black&#44; blue&#47;gray&#44; red&#47;pink&#44; white&#41;&#44; asymmetry of color&#47;structures&#44; atypical&#44; pigmented network&#44; irregular globules&#44; streaks&#44; irregular blotches&#44; shiny white streaks&#44; negative pigment o brown areas&#44; blue-black pigmentation&#44; milky-red areas&#44; rainbow pattern&#44; pseudolacunae&#44; ulceration&#44; and irregular vessels&#46; Data were analyzed using SPSS version 22&#46;0 &#40;Chicago&#44; IL&#44; USA&#41;&#46; Interobserver agreement between the five dermoscopists was evaluated using the Fleiss&#8217; Kappa statistic test&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The results of the concordance analysis are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; Most of the dermoscopic features ranged Kappa values between 0&#46;3&#8210;0&#46;5&#44; which can be considered fair to moderate&#46; Asymmetry of color and structures &#40;yes&#47;no&#41; showed a moderate agreement &#40;0&#46;46&#8210;0&#46;49&#41;&#44; slightly higher than the same evaluation considering one or two axes&#46; The presence of more than three colors presented the moderate agreement as well &#40;0&#46;46&#41;&#46; The melanoma-specific structures that showed more consistency were the shiny white streaks &#40;up to 0&#46;55&#41;&#44; while structureless brown areas had the worst results &#40;0&#46;05&#41;&#46; A few features that have been recently described&#44; such as prominent skin markings and blue-black pigmentation&#44; showed a very poor correlation &#40;0&#46;23 and 0&#46;18&#44; respectively&#41; between all observers&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Previous studies have determined that features regarding the overall organization&#44; colors&#44; and symmetries have a higher agreement and discriminatory power than many well-known diagnostic structures such as atypical pigment networks or irregular blotches&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> Recent dermoscopic algorithms&#44; such as CASH and TADA algorithms&#44; are based on this idea&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> This finding has been confirmed in our concordance analysis and supports this approach&#46; On the other hand&#44; the low values observed in novel features such as prominent skin markings and blue-black pigmentation are noteworthy&#46; Although these features have been well-defined&#44; and their identification may be useful to increase the suspicion of certain lesions&#44; their interobserver agreement might seem too low to be reliable in clinical practice&#46; This variability is expected to be more striking&#44; especially between non-expert dermoscopists&#44; limiting their efficacy on a diagnosis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Dermoscopy might be a subjective diagnostic tool&#44; and its efficacy in detecting malignant lesions dependable on previous experience&#46; We consider that basic algorithms for non-experts should include only dermoscopic structures that are easily identified by most dermatologists&#46; Limitations of our study are its retrospective and single-institution design&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Enrique Rodr&#237;guez-Lomba&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; statistical analysis&#59; study conception and planning&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Bel&#233;n Lozano-Masdemont&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; critical manuscript review&#59; preparation and writing of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Lula Mar&#237;a Nieto-Benito&#58; Approval of the final version of the manuscript&#59; data collection&#44; analysis&#44; and interpretation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; critical manuscript review&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Elisa Hern&#225;ndez de la Torre&#58; Approval of the final version of the manuscript&#59; data collection&#44; analysis&#44; and interpretation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; critical manuscript review&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Ricardo Su&#225;rez-Fern&#225;ndez&#58; Approval of the final version of the manuscript&#59; data collection&#44; analysis&#44; and interpretation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; critical manuscript review&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Jos&#233; Antonio Avil&#233;s-Izquierdo&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; critical manuscript review&#59; preparation and writing of the manuscript&#59; statistical analysis&#59; study conception and planning&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melanocytic nevus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melanocytic nevus with histopathological atypia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Blue nevus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spitz nevus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Basal cell carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Seborrheic keratosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dermatofibroma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Squamous cell carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Other neoplasms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2906291.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Distribution of diagnosis in the 200 cases for evaluation&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">K</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Three or more colors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Color asymmetry &#40;yes&#47;no&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Structure asymmetry &#40;yes&#47;no&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Color asymmetry &#40;0&#8210;2 axes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Structure asymmetry &#40;0&#8210;2 axes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Shiny white streaks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Polymorphous vascular pattern&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regression&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Streaks&#47;pseudopods&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atypical pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pseudolacunae&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Irregular globules&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">Irregular blotches&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Structureless brown areas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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Journal Information
Vol. 97. Issue 3.
Pages 382-384 (1 May 2022)
Visits
4143
Vol. 97. Issue 3.
Pages 382-384 (1 May 2022)
Research Letter
Open Access
Concordance analysis of dermoscopic features between five observers in a sample of 200 dermoscopic images
Visits
4143
Enrique Rodríguez-Lombaa,
Corresponding author
enriquerlomba@outlook.com

Corresponding author.
, Belén Lozano-Masdemontb, Lula María Nieto-Benitoa, Elisa Hernández de la Torrea, Ricardo Suárez-Fernándeza, José Antonio Avilés-Izquierdoa
a Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Department of Dermatology, Hospital Universitario de Móstoles, Madrid, Spain
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Tables (2)
Table 1. Distribution of diagnosis in the 200 cases for evaluation.
Table 2. Interobserver agreement of colors and dermoscopic structures (Fleiss’ Kappa statistical test).
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Full Text
Dear Editor,

Dermoscopy is a non-invasive technique that has been proven in recent metanalysis to increase the accuracy in the diagnosis of cutaneous melanoma compared to the naked eye examination. However, its application can be considered subjective and too observer-dependent, with a heavy influence by previous experience. To this date, few reproducibility studies focusing on interobserver agreement of dermoscopic images have been published. Most of them are based on the evaluation of <50 cases by each observer.1–3 Furthermore, since the Internet Consensus Meeting of 40 dermoscopy experts in 2003, a few novel dermoscopic features have been described that were not evaluated.1

The aim of this project was to analyze and determine the reproducibility of the analysis of both classic and novel dermoscopic features for the diagnosis of melanoma in 200 dermoscopic images by five blinded observers (E.H.T., L.N.B, JAAI, BLM, ERL). Previous experience on dermoscopy was >10 years (1 observer), >5 years (2 observers), and <5 years (2 observers).

A retrospective evaluation of dermoscopic images collected from the database of the Melanoma Unit in our department was performed. Images were obtained using a digital polarized dermoscopy system (Dermlite Photo II Pro HR® [3Gen®, San Juan Capistrano, CA, USA] and an Olympus E-420® camera [Olympus, Tokyo, Japan]). Lesion diameter had to fit in the picture to be included. Cases without histopathological confirmation, melanoma metastases, or melanomas of special sites (facial, acral, nail, genital, or mucosal melanoma) were excluded. The distribution of diagnosis in our sample is shown in Table 1.

Table 1.

Distribution of diagnosis in the 200 cases for evaluation.

Diagnosis 
Melanoma  99  49.5 
Melanocytic nevus  45  22.5 
Melanocytic nevus with histopathological atypia  22  11.0 
Blue nevus  2.5 
Spitz nevus  2.0 
Basal cell carcinoma  14  7.0 
Seborrheic keratosis  2.5 
Dermatofibroma  1.0 
Squamous cell carcinoma  1.0 
Other neoplasms  1.0 
Total  200  100 

The following dermoscopic features were analyzed: colors (light brown, dark brown, black, blue/gray, red/pink, white), asymmetry of color/structures, atypical, pigmented network, irregular globules, streaks, irregular blotches, shiny white streaks, negative pigment o brown areas, blue-black pigmentation, milky-red areas, rainbow pattern, pseudolacunae, ulceration, and irregular vessels. Data were analyzed using SPSS version 22.0 (Chicago, IL, USA). Interobserver agreement between the five dermoscopists was evaluated using the Fleiss’ Kappa statistic test.

The results of the concordance analysis are shown in Table 2. Most of the dermoscopic features ranged Kappa values between 0.3‒0.5, which can be considered fair to moderate. Asymmetry of color and structures (yes/no) showed a moderate agreement (0.46‒0.49), slightly higher than the same evaluation considering one or two axes. The presence of more than three colors presented the moderate agreement as well (0.46). The melanoma-specific structures that showed more consistency were the shiny white streaks (up to 0.55), while structureless brown areas had the worst results (0.05). A few features that have been recently described, such as prominent skin markings and blue-black pigmentation, showed a very poor correlation (0.23 and 0.18, respectively) between all observers.

Table 2.

Interobserver agreement of colors and dermoscopic structures (Fleiss’ Kappa statistical test).

  K 
Three or more colors  0.46 
Color asymmetry (yes/no)  0.46 
Structure asymmetry (yes/no)  0.49 
Color asymmetry (0‒2 axes)  0.35 
Structure asymmetry (0‒2 axes)  0.36 
Shiny white streaks  0.55 
Polymorphous vascular pattern  0.48 
Regression  0.47 
Streaks/pseudopods  0.45 
Atypical pigment network  0.42 
Pseudolacunae  0.41 
Negative pigment network  0.40 
Irregular globules  0.38 
Irregular vessels  0.37 
Irregular blotches  0.37 
Blue-white veil  0.35 
Rainbow pattern  0.34 
Milky red areas  0.30 
Prominent skin markings  0.23 
Blue-black pigmentation  0.18 
Hypopigmented areas  0.16 
Structureless brown areas  0.05 

Previous studies have determined that features regarding the overall organization, colors, and symmetries have a higher agreement and discriminatory power than many well-known diagnostic structures such as atypical pigment networks or irregular blotches.1–3 Recent dermoscopic algorithms, such as CASH and TADA algorithms, are based on this idea.4,5 This finding has been confirmed in our concordance analysis and supports this approach. On the other hand, the low values observed in novel features such as prominent skin markings and blue-black pigmentation are noteworthy. Although these features have been well-defined, and their identification may be useful to increase the suspicion of certain lesions, their interobserver agreement might seem too low to be reliable in clinical practice. This variability is expected to be more striking, especially between non-expert dermoscopists, limiting their efficacy on a diagnosis.

Dermoscopy might be a subjective diagnostic tool, and its efficacy in detecting malignant lesions dependable on previous experience. We consider that basic algorithms for non-experts should include only dermoscopic structures that are easily identified by most dermatologists. Limitations of our study are its retrospective and single-institution design.

Financial support

None declared.

Authors’ contributions

Enrique Rodríguez-Lomba: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; manuscript critical review; preparation and writing of the manuscript; statistical analysis; study conception and planning.

Belén Lozano-Masdemont: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; critical manuscript review; preparation and writing of the manuscript.

Lula María Nieto-Benito: Approval of the final version of the manuscript; data collection, analysis, and interpretation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; critical manuscript review.

Elisa Hernández de la Torre: Approval of the final version of the manuscript; data collection, analysis, and interpretation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; critical manuscript review.

Ricardo Suárez-Fernández: Approval of the final version of the manuscript; data collection, analysis, and interpretation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; critical manuscript review.

José Antonio Avilés-Izquierdo: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; critical manuscript review; preparation and writing of the manuscript; statistical analysis; study conception and planning.

Conflicts of interest

None declared.

References
[1]
G. Argenziano, H.P. Soyer, S. Chimenti, R. Talamini, R. Corona, F. Sera, et al.
Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet.
J Am Acad Dermatol, 48 (2003), pp. 679-693
[2]
C. Dolianitis, J. Kelly, R. Wolfe, P. Simpson.
Comparative performance of 4 dermoscopic algorithms by non-experts for the diagnosis of melanocytic lesions.
Arch Dermatol, 141 (2005), pp. 1008-1014
[3]
C. Carrera, M.A. Marchetti, S.W. Dusza, G. Argenziano, R.P. Braun, A.C. Halpern, et al.
Validity and reliability of dermoscopic criteria used to differentiate nevi from melanoma. A Web-Based International Dermoscopy Society Study.
JAMA Dermatol, 152 (2016), pp. 798-806
[4]
T. Rogers, M.L. Marino, S.W. Dusza, S. Bajaj, R.P. Usatine, M.A. Marchetti, et al.
A Clinical Aid for Detecting Skin Cancer: The Triage Amalgamated Dermoscopic Algorithm (TADA).
J Am Board Fam Med, 29 (2016), pp. 694-701
[5]
J.S. Henning, S.W. Dusza, S.Q. Wang, A.A. Marghoob, H.S. Rabinovitz, D. Polsky, et al.
The CASH (color, architecture, symmetry, and homogeneity) algorithm for dermoscopy.
J Am Acad Dermatol, 56 (2007), pp. 45-52

Study was conducted using data from patients obtained from the Melanoma Unit of the Hospital General Universitario Gregorio Marañón, Madrid, Spain.

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