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an <span class="elsevierStyleItalic">in vivo</span> non-invasive imaging examination at the cellular level&#44; which showed a fenestrated pattern&#44; with the presence of refractive tumor cords&#44; forming anastomoses and islets of basaloid cells&#44; surrounded by fibrous&#44; hyporefractive stroma&#46; Basaloid cells in palisade arrangement were also observed at the periphery of the cords &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Histopathological analysis was performed and confirmed the diagnosis of fibroepithelioma of Pinkus &#40;FeP&#41;&#44; characterized by interconnected cords of tumor cells&#44; with peripheral palisade&#44; surrounded by fibrous stroma &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>A&#41;&#46; Immunohistochemical analysis showed the expression of the Ber-EP4 in the cords of tumor cells &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>B&#41;&#46; At the lower limit&#44; structures called germ-papillae&#44; characteristic of FeP&#44; were observed&#46; The histological arrangement corresponds to the fenestrated pattern on confocal microscopy&#44; allowing the safe diagnosis of FeP by this technique&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">FeP is a peculiar and uncommon subtype of basal cell carcinoma&#44; which can be clinically similar to benign tumor lesions&#44; such as intradermal nevus&#44; fibroepithelial polyp&#44; and seborrheic keratosis&#44; among others&#44; which are not routinely excised&#46; Classically&#44; FeP presents as a solitary&#44; cupuliform&#44; normochromic&#44; or brownish papule&#46; Dermoscopy may show polymorphous vessels &#40;thin&#44; focused&#44; short arboriform&#44; dotted&#41;&#44; short white lines&#44; milia-like cysts&#44; brownish-gray areas&#44; and bluish-gray dots&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Histopathology is considered essential for diagnosis&#46; It was described by Pinkus as peculiar and unmistakable&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> it features filaments or anastomosing cords of basaloid cells projecting downwards from the epidermis in a fenestrated pattern&#44; surrounded by abundant fibrous stroma&#46; The periphery of the cords is formed by columnar cells&#44; in palisade arrangement&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Immunohistochemistry using the Ber-EP4 marker is a useful tool to diagnose neoplasms with follicular germinative differentiation and can be used to corroborate the histopathological diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">In vivo</span> confocal microscopy also shows the characteristic fenestrated pattern&#46; At the level of the dermal-epidermal junction&#44; hyporefrective spaces can be observed&#44; which correspond to the fibrous stroma&#44; surrounded by cords of tumor cells&#44; with greater refraction&#46; Cords and islets of tumor cells show a palisade arrangement at the periphery and canalicular vessels may also be observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">FeP often goes underdiagnosed on clinical examination&#46; The clinical characteristics are often nonspecific and dermoscopy may not be sufficient to confirm or rule out other hypotheses&#46; However&#44; the specific pattern revealed by confocal microscopy corresponds to the peculiar histopathological characteristics of FeP&#44; making its diagnosis possible with a higher level of safety and specificity&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;8</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#39; contributions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Gabriella Campos do Carmo das Chagas&#58; Design and planning of the study&#59; data collection&#44; or analysis and interpretation of the data&#59; drafting and editing of the manuscript or critical review of important intellectual content&#59; collection&#44; analysis and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; approval of the final version of the manuscript&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">J&#250;lia Bozetti L&#243;ss&#58; Data collection&#44; or analysis and interpretation of data&#59; drafting and editing of the manuscript or critical review of important intellectual content&#59; collection&#44; analysis and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; approval of the final version of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Gustavo Costa Verardino&#58; Data collection&#44; or data analysis and interpretation&#59; drafting and editing of the manuscript or critical review of important intellectual content&#59; collection&#44; analysis and interpretation of data&#59; approval of the final version of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Vol. 98. Núm. 6.
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Vol. 98. Núm. 6.
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Letter - Clinical
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Fibroepithelioma of Pinkus – confocal microscopy as a diagnostic tool
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Gabriella Campos-do-Carmoa,
Autor para correspondência
dragabriellacampos@gmail.com

Corresponding author.
, Júlia Bozetti Lóssa, Gustavo Costa Verardinob
a Department of Dermatology, Gávea Medical Center, Rio de Janeiro, RJ, Brazil
b Department of Pathology, Microimagem, Rio de Janeiro, RJ, Brazil
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Dear Editor,

A 36-year-old female patient presented with an asymptomatic pigmented lesion on her abdomen during total body mapping examination. The patient had no personal history of skin cancer, although she had already had atypical nevi removed.

Clinically, the lesion appeared as a brownish, sessile papule, measuring approximately 0.8cm (Fig. 1). On dermoscopy, the presence of multiple bluish-gray dots were seen in the middle of the brownish amorphous area, as well as discrete thin vessels (Fig. 2).

Figure 1.

Brownish, sessile papule, measuring approximately 0.8cm

(0.1MB).
Figure 2.

Dermoscopic image: presence of multiple bluish-gray dots in the middle of the brownish amorphous area and discrete thin vessels

(0.09MB).

Confocal reflectance microscopy was performed, an in vivo non-invasive imaging examination at the cellular level, which showed a fenestrated pattern, with the presence of refractive tumor cords, forming anastomoses and islets of basaloid cells, surrounded by fibrous, hyporefractive stroma. Basaloid cells in palisade arrangement were also observed at the periphery of the cords (Figs. 3 and 4).

Figure 3.

In vivo confocal microscopy mosaic: presence of interconnected cords and islets of tumor cells (red arrows), forming anastomoses, surrounded by fibrous stroma (blue arrows)

(0.48MB).
Figure 4.

(A and B) In vivo confocal microscopy: islets and cords of tumor cells with a palisade periphery (red arrows), forming anastomoses, surrounded by fibrous stroma (blue arrows)

(0.99MB).

Histopathological analysis was performed and confirmed the diagnosis of fibroepithelioma of Pinkus (FeP), characterized by interconnected cords of tumor cells, with peripheral palisade, surrounded by fibrous stroma (Fig. 5A). Immunohistochemical analysis showed the expression of the Ber-EP4 in the cords of tumor cells (Fig. 5B). At the lower limit, structures called germ-papillae, characteristic of FeP, were observed. The histological arrangement corresponds to the fenestrated pattern on confocal microscopy, allowing the safe diagnosis of FeP by this technique.

Figure 5.

(A) Histopathology of the lesion showing cords of tumor cells with a palisaded periphery (Hematoxylin & eosin, ×40). (B) Immunohistochemistry demonstrating the expression of BER-EP4 in the cords of tumor cells (×40)

(0.33MB).

FeP is a peculiar and uncommon subtype of basal cell carcinoma, which can be clinically similar to benign tumor lesions, such as intradermal nevus, fibroepithelial polyp, and seborrheic keratosis, among others, which are not routinely excised. Classically, FeP presents as a solitary, cupuliform, normochromic, or brownish papule. Dermoscopy may show polymorphous vessels (thin, focused, short arboriform, dotted), short white lines, milia-like cysts, brownish-gray areas, and bluish-gray dots.1–3

Histopathology is considered essential for diagnosis. It was described by Pinkus as peculiar and unmistakable,4 it features filaments or anastomosing cords of basaloid cells projecting downwards from the epidermis in a fenestrated pattern, surrounded by abundant fibrous stroma. The periphery of the cords is formed by columnar cells, in palisade arrangement.5,6 Immunohistochemistry using the Ber-EP4 marker is a useful tool to diagnose neoplasms with follicular germinative differentiation and can be used to corroborate the histopathological diagnosis.7

In vivo confocal microscopy also shows the characteristic fenestrated pattern. At the level of the dermal-epidermal junction, hyporefrective spaces can be observed, which correspond to the fibrous stroma, surrounded by cords of tumor cells, with greater refraction. Cords and islets of tumor cells show a palisade arrangement at the periphery and canalicular vessels may also be observed.2,3

FeP often goes underdiagnosed on clinical examination. The clinical characteristics are often nonspecific and dermoscopy may not be sufficient to confirm or rule out other hypotheses. However, the specific pattern revealed by confocal microscopy corresponds to the peculiar histopathological characteristics of FeP, making its diagnosis possible with a higher level of safety and specificity.5,8

Financial support

None declared.

Authors' contributions

Gabriella Campos do Carmo das Chagas: Design and planning of the study; data collection, or analysis and interpretation of the data; drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis and interpretation of data; effective participation in research orientation; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; approval of the final version of the manuscript.

Júlia Bozetti Lóss: Data collection, or analysis and interpretation of data; drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis and interpretation of data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; approval of the final version of the manuscript.

Gustavo Costa Verardino: Data collection, or data analysis and interpretation; drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis and interpretation of data; approval of the final version of the manuscript.

Conflicts of interest

None declared.

References
[1]
C. Longo, H.P. Soyer, P. Pepe, A. Casari, E.M.T. Wurm, P. Guitera, et al.
In vivo confocal microscopic pattern of Fibroepithelioma of Pinkus.
Arch Dermatol., 148 (2012), pp. 556
[2]
C. Reggiani, I. Zalaudek, S. Piana, C. Longo, G. Argenziano, A. Lallas, et al.
Fibroepithelioma of Pinkus: case reports and review of the literature.
Dermatology., 226 (2013), pp. 207-211
[3]
M. Viera, S. Amini, R. Huo, M. Oliviero, S. Bassalo, H. Rabinovitz.
A new look at Fibroepithelioma of Pinkus: features on confocal microscopy.
J Clin Aesthet Dermatol., 1 (2008), pp. 42-44
[4]
H. Pinkus.
Premalignant fibroepithelial tumors of skin.
AMA Arch Derm Syphilol., 67 (1953), pp. 598-615
[5]
E.S. Haddock, P.R. Cohen.
Fibroepithelioma of Pinkus revisited.
Dermatol Ther (Heidelb)., 6 (2016), pp. 347-362
[6]
M. Lupu, V.G. Clatici, E. Barinova, V.M. Voiculescu.
Fibroepithelioma of Pinkus: dermoscopic and reflectance confocal microscopic patterns.
Dermatol Ther., 34 (2021),
[7]
S. Ansai, R. Takayama, T. Kimura, S. Kawana.
Ber-EP4 is a useful marker for follicular germinative cell differentiation of cutaneous epithelial neoplasms.
J Dermato., 39 (2012), pp. 688-692
[8]
B.A. Badaró, L.M. Diniz, E. Negris Neto, E.A. Lucas.
Multiple Fibroepitheliomas of Pinkus after radiotherapy.
An Bras Dermatol., 94 (2019), pp. 633-635

Study conducted at the Department of Dermatology, Gávea Medical Center; and Department of Pathology, Microimagem, Rio de Janeiro, RJ, Brazil.

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