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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Nevo melanoc&#237;tico pedi&#225;trico com di&#226;metro de 3&#44;5<span class="elsevierStyleHsp" style=""></span>mm&#44; com padr&#227;o homog&#234;neo&#8208;globular no centro e gl&#243;bulos perif&#233;ricos dispostos regularmente em fileira &#250;nica&#46; &#40;B&#41; Aumento no di&#226;metro do nevo para 4&#44;3<span class="elsevierStyleHsp" style=""></span>mm ap&#243;s 12 meses com n&#250;mero semelhante de gl&#243;bulos perif&#233;ricos&#46; &#40;C&#41; O aumento do di&#226;metro do nevo continuou&#44; com diminui&#231;&#227;o dos gl&#243;bulos perif&#233;ricos&#46; &#40;D&#41; Aumento percept&#237;vel na estrutura homog&#234;nea central e diminui&#231;&#227;o significante dos gl&#243;bulos perif&#233;ricos&#59; o nevo come&#231;ou a se estabilizar com di&#226;metro de 4&#44;6<span class="elsevierStyleHsp" style=""></span>mm no 36&#176; m&#234;s de seguimento&#46;</p>"
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valioso para distingui&#8208;las das neoplasias malignas&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Altera&#231;&#245;es que causam suspeita de melanoma em adultos s&#227;o frequentes na faixa et&#225;ria pedi&#225;trica&#44; por se tratar de um per&#237;odo din&#226;mico no desenvolvimento do indiv&#237;duo&#46; Sabe&#8208;se que existe uma varia&#231;&#227;o nos di&#226;metros&#44; quantidade e padr&#245;es dos nevos melanoc&#237;ticos nas diferentes faixas et&#225;rias&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a> Em virtude do n&#250;mero limitado de estudos na literatura sobre monitoramento dermatosc&#243;pico de nevos pedi&#225;tricos&#44; o presente estudo teve como objetivo mostrar o padr&#227;o din&#226;mico e as modifica&#231;&#245;es de di&#226;metro em nevos pedi&#225;tricos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todo</span><p id="par0015" class="elsevierStylePara elsevierViewall">No presente estudo&#44; foram inclu&#237;dos pacientes que se inscreveram na <span class="elsevierStyleItalic">Dermatology Clinic of &#304;stanbul Training and Research Hospital</span> entre janeiro de 2008 e 2022 e foram diagnosticados com nevo melanoc&#237;tico pedi&#225;trico cl&#237;nica e dermatoscopicamente&#46; Foram inclu&#237;dos pacientes que tinham sido atendidos pelo menos duas vezes com videodermoscopia a cada tr&#234;s meses&#46; O presente estudo avaliou 301 nevos melanoc&#237;ticos pedi&#225;tricos em 50 pacientes&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Os registros dermatosc&#243;picos dos indiv&#237;duos inclu&#237;dos no estudo foram realizados com FotoFinderdermoscope &#40;FotoFinder Systems GmbH&#44; Bad Birnbach&#44; Alemanha&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">O estudo foi aprovado pelo Comit&#234; de &#201;tica local&#46; Prontu&#225;rios e fotografias dos pacientes foram revisados retrospectivamente por meio dos registros do hospital e de banco de dados de videodermoscopia&#46; Os pacientes inclu&#237;dos neste estudo deram consentimento informado por escrito para a publica&#231;&#227;o dos detalhes de seus casos&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As seguintes caracter&#237;sticas foram registradas em um banco de dados projetado especificamente para o estudo&#58; achados demogr&#225;ficos dos pacientes&#44; localiza&#231;&#227;o do nevo&#44; padr&#227;o do nevo &#40;basal e seguimento&#41;&#44; di&#226;metro do nevo &#40;basal e seguimento em 3&#44; 12 e 36 meses&#41;&#44; e foram registrados os resultados histopatol&#243;gicos dos nevos submetidos &#224; excis&#227;o total&#46; A mudan&#231;a no di&#226;metro do nevo durante o seguimento foi medida em mil&#237;metros com base no eixo mais longo&#46; A presen&#231;a de gl&#243;bulos perif&#233;ricos&#44; a evolu&#231;&#227;o dos gl&#243;bulos perif&#233;ricos e suas caracter&#237;sticas foram registrados&#46; As caracter&#237;sticas dos gl&#243;bulos perif&#233;ricos foram avaliadas de acordo com o fato de ser circundante &#224; les&#227;o &#40;circunferencial&#41; <span class="elsevierStyleItalic">versus</span> presen&#231;a focal&#44; t&#237;pico &#40;formato e cores uniformes&#41; e ser regular &#40;fileira &#250;nica de gl&#243;bulos ou m&#250;ltiplas fileiras de gl&#243;bulos&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">An&#225;lise estat&#237;stica</span><p id="par0035" class="elsevierStylePara elsevierViewall">As an&#225;lises estat&#237;sticas foram realizadas no programa SPSS vers&#227;o 23&#46;0&#46; A conformidade das vari&#225;veis &#224; distribui&#231;&#227;o normal foi avaliada por meio de gr&#225;ficos de histograma e teste de Kolmogorov&#8208;Smirnov&#47;Shapiro&#8208;Wilk&#46; Foram utilizados m&#233;dia&#44; desvio padr&#227;o&#44; mediana&#44; valores m&#237;nimo e m&#225;ximo na apresenta&#231;&#227;o das an&#225;lises descritivas&#46; O teste <span class="elsevierStyleItalic">U</span> de Mann&#8208;Whitney foi utilizado na avalia&#231;&#227;o de vari&#225;veis com distribui&#231;&#227;o n&#227;o normal &#40;n&#227;o param&#233;tricas&#41; entre dois grupos&#44; e o teste de Kruskal Wallis foi utilizado na avalia&#231;&#227;o entre mais de dois grupos&#46; O teste de compara&#231;&#245;es m&#250;ltiplas de Bonferroni foi utilizado para diferen&#231;a significante entre os grupos&#46; Na apresenta&#231;&#227;o das vari&#225;veis categ&#243;ricas&#44; foram utilizados os valores de frequ&#234;ncia e percentuais das vari&#225;veis&#59; valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 foi considerado resultado estatisticamente significante&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Resultados</span><p id="par0040" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos no estudo 50 pacientes com um total de 301 nevos&#46; As caracter&#237;sticas demogr&#225;ficas&#44; cl&#237;nicas e histopatol&#243;gicas dos pacientes s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; Dos pacientes&#44; 46&#37; eram do g&#234;nero feminino &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#41;&#44; com m&#233;dia de idade de 11&#44;5 anos&#46; Em 90&#37; dos casos foi observado envolvimento do tronco e extremidades&#44; em 6&#37; envolvimento palmoplantar e em 4&#37; envolvimento do couro cabeludo&#47;face&#46; O padr&#227;o globular foi detectado em 40&#37; na linha de base e diminuiu para 30&#37; no seguimento&#46; Padr&#227;o reticular foi detectado em 31&#37; dos casos&#44; e nenhuma altera&#231;&#227;o foi observada no seguimento&#46; O padr&#227;o de nevo homog&#234;neo basal foi encontrado em 10&#37;&#44; e detectado em 13&#44;9&#37; no seguimento&#46; A propor&#231;&#227;o do padr&#227;o de nevo homog&#234;neo&#47;reticular homog&#234;neo&#47;globular homog&#234;neo foi de 18&#44;1&#37; na linha de base e aumentou para 27&#44;3&#37; no seguimento&#46; Nenhuma diferen&#231;a significante foi observada nas propor&#231;&#245;es de sulcos paralelos&#44; padr&#245;es fibrilares e reticulares&#46; N&#227;o houve diferen&#231;a significante no tamanho dos nevos por localiza&#231;&#227;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;6&#41;&#46; A presen&#231;a de gl&#243;bulos perif&#233;ricos foi observada em 19&#44;3&#37; dos casos&#46; No seguimento&#44; 61&#44;1&#37; dos gl&#243;bulos regrediram completamente&#44; 13&#37; diminu&#237;ram e 5&#44;6&#37; aumentaram&#46; Em 20&#44;4&#37; dos casos&#44; nenhuma altera&#231;&#227;o foi observada no n&#250;mero de gl&#243;bulos perif&#233;ricos durante o per&#237;odo de seguimento&#46; O aumento do di&#226;metro do nevo ao longo do tempo&#44; acompanhado pela diminui&#231;&#227;o dos gl&#243;bulos perif&#233;ricos e&#44; finalmente&#44; a fase de estabiliza&#231;&#227;o do nevo &#233; mostrado na <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46; A <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> mostra a homogeneiza&#231;&#227;o no padr&#227;o dos nevos em transi&#231;&#227;o para a fase de estabiliza&#231;&#227;o&#44; bem como o desbotamento da cor&#46; Junto com a estabiliza&#231;&#227;o&#44; ocorre redu&#231;&#227;o do padr&#227;o globular e acentua&#231;&#227;o do componente d&#233;rmico em alguns nevos&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Gl&#243;bulos perif&#233;ricos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>58&#41; foram observados em 86&#37; com caracter&#237;sticas circunferenciais&#44; 93&#37; regulares e 94&#37; t&#237;picas&#46; Excis&#227;o do nevo foi indicada em apenas 11 dos 301 nevos&#44; e os nevos excisados foram diagnosticados como nevos displ&#225;sicos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; compostos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#44; juncionais &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41; e nevo de Spitz &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#46; A m&#233;dia de idade de acordo com o padr&#227;o est&#225; resumida na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46; N&#227;o houve diferen&#231;a na altera&#231;&#227;o do di&#226;metro em rela&#231;&#227;o com a presen&#231;a de gl&#243;bulos perif&#233;ricos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;1&#41;&#44; como mostrado na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclus&#227;o</span><p id="par0050" class="elsevierStylePara elsevierViewall">O presente estudo avaliou as taxas de crescimento&#44; caracter&#237;sticas dermatosc&#243;picas e altera&#231;&#245;es de padr&#227;o no per&#237;odo de seguimento de nevos pedi&#225;tricos&#46; Os nevos melanoc&#237;ticos pedi&#225;tricos podem apresentar altera&#231;&#245;es din&#226;micas em compara&#231;&#227;o aos nevos em adultos&#44; e as altera&#231;&#245;es de padr&#227;o relatadas na literatura s&#227;o vari&#225;veis&#46; O padr&#227;o globular foi observado com maior frequ&#234;ncia no presente estudo na faixa et&#225;ria pedi&#225;trica&#46; Esse &#233; o padr&#227;o predominante em crian&#231;as e adolescentes&#44; e foi relatado que o padr&#227;o reticular aumenta com a idade&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;2</span></a> O n&#250;mero de nevos globulares diminui com a idade&#44; at&#233; chegar a 1&#37; em idade avan&#231;ada &#40;&#62; 75&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Acredita&#8208;se que os nevos globulares persistem&#44; mas adquirem caracter&#237;sticas d&#233;rmicas e apar&#234;ncia homog&#234;nea&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> No presente estudo&#44; foi observado que a taxa do padr&#227;o globular&#44; que era de 40&#37;&#44; diminuiu para 30&#37; ao longo do tempo&#46; Descobriu&#8208;se que o padr&#227;o globular mudou para padr&#227;o homog&#234;neo&#47;globular homog&#234;neo&#44; j&#225; que os outros padr&#245;es permaneceram praticamente constantes&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Existem muitos estudos e conceitos relacionados &#224; nevog&#234;nese&#46; Como os padr&#245;es globulares e reticulares mostram altera&#231;&#245;es relacionadas &#224; idade&#44; acreditava&#8208;se que a nevog&#234;nese ocorria por diferentes vias&#46; Na primeira via os nevos com padr&#227;o globular se desenvolvem com grandes ninhos d&#233;rmicos na inf&#226;ncia&#44; que&#44; acredita&#8208;se&#44; mant&#234;m seu padr&#227;o geral &#224; medida que a crian&#231;a cresce&#46; Na segunda via de nevog&#234;nese os melan&#243;citos epid&#233;rmicos se desenvolvem em padr&#227;o reticular&#44; na idade adulta e sofrem influ&#234;ncia de fatores externos&#44; como exposi&#231;&#227;o intermitente aos raios ultravioleta&#46; Do ponto de vista histopatol&#243;gico&#44; os nevos globulares aparecem na inf&#226;ncia e os gl&#243;bulos geralmente est&#227;o no componente d&#233;rmico&#46; Os nevos reticulares mostram desenvolvimento juncional&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Embora uma transi&#231;&#227;o do padr&#227;o globular para reticular tenha sido mencionada em v&#225;rios estudos&#44; tal mudan&#231;a de padr&#227;o n&#227;o foi aparente no presente estudo&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">5&#44;6</span></a> Tempos de seguimento mais longos podem ser necess&#225;rios para aumentar a observa&#231;&#227;o do padr&#227;o reticular em consequ&#234;ncia das altera&#231;&#245;es induzidas pela radia&#231;&#227;o ultravioleta&#46; Existe a hip&#243;tese de que os nevos globulares evoluam dermatoscopicamente de duas maneiras&#46; A primeira &#233; a progress&#227;o para nevo intrad&#233;rmico &#8211; essa condi&#231;&#227;o pode ser acompanhada de aspecto papilomatoso ou sem estrutura&#44; e o nevo pode evoluir para uma colora&#231;&#227;o mais clara&#46; A segunda &#233; a evolu&#231;&#227;o em dire&#231;&#227;o ao padr&#227;o misto&#44; que pode ser sem estrutura acompanhado de linhas reticulares ou pode ter a apar&#234;ncia de um ovo frito&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Existem estudos nos quais a classifica&#231;&#227;o dermatosc&#243;pica &#233; avaliada por correla&#231;&#227;o com a microscopia confocal de reflect&#226;ncia &#40;MCR&#41; longitudinal&#46; Esses estudos apoiaram a ideia de que a nevog&#234;nese ocorre por duas vias&#59; entretanto&#44; n&#227;o foram observadas altera&#231;&#245;es significantes nos nevos com MCR durante o seguimento&#44; e as raras altera&#231;&#245;es observadas tamb&#233;m ocorreram no mesmo compartimento &#40;epid&#233;rmico ou juncional e d&#233;rmico&#41;&#46; Essa observa&#231;&#227;o contestou os paradigmas da migra&#231;&#227;o descendente ou ascendente dos melan&#243;citos&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">7&#8208;9</span></a> Por outro lado&#44; esse estudo foi realizado em adultos&#44; e mais estudos s&#227;o necess&#225;rios para mostrar a evolu&#231;&#227;o dos nevos com MCR na faixa et&#225;ria pedi&#225;trica&#44; na qual ocorrem as principais mudan&#231;as din&#226;micas&#46; Assim&#44; a correspond&#234;ncia dessas altera&#231;&#245;es dermatosc&#243;picas din&#226;micas observadas na faixa et&#225;ria pedi&#225;trica com a MCR elucidar&#225; a evolu&#231;&#227;o do nevo&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">A presen&#231;a de gl&#243;bulos perif&#233;ricos &#233; frequentemente observada em nevos melanoc&#237;ticos pedi&#225;tricos e estava presente em 19&#37; dos casos no presente estudo&#46; As propor&#231;&#245;es de gl&#243;bulos perif&#233;ricos atingem o pico na faixa et&#225;ria dos adolescentes e depois diminuem rapidamente&#46; Durante o per&#237;odo de seguimento&#44; observou&#8208;se regress&#227;o dos gl&#243;bulos perif&#233;ricos na maioria dos casos do presente estudo&#46; Gl&#243;bulos perif&#233;ricos s&#227;o um achado esperado na faixa et&#225;ria pedi&#225;trica e&#44; em geral&#44; n&#227;o requerem interven&#231;&#227;o adicional&#46; No entanto&#44; ap&#243;s os 30 anos&#44; recomenda&#8208;se seguimento dermatosc&#243;pico digital cuidadoso&#44; mesmo na aus&#234;ncia de outros crit&#233;rios espec&#237;ficos de melanoma&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> A presen&#231;a de crit&#233;rios espec&#237;ficos de melanoma&#44; como borr&#245;es&#44; pontos e gl&#243;bulos at&#237;picos ou vasos at&#237;picos com presen&#231;a de gl&#243;bulos perif&#233;ricos&#44; configura maior risco de melanoma&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">No presente estudo&#44; os gl&#243;bulos perif&#233;ricos eram frequentemente circunferenciais&#44; regulares e t&#237;picos&#46; Foi relatado que os gl&#243;bulos perif&#233;ricos nos nevos melanoc&#237;ticos s&#227;o t&#237;picos e circunferenciais&#46; A distribui&#231;&#227;o at&#237;pica e assim&#233;trica de gl&#243;bulos perif&#233;ricos apoia o diagn&#243;stico de melanoma&#44; especialmente na faixa et&#225;ria adulta&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> Melanoma n&#227;o foi detectado na presen&#231;a de gl&#243;bulos perif&#233;ricos em nenhum dos casos do presente estudo&#44; mesmo quando apresentavam aspecto at&#237;pico&#46; Embora gl&#243;bulos perif&#233;ricos estejam associados ao crescimento dos nevos&#44; n&#227;o foram observadas altera&#231;&#245;es significantes no di&#226;metro em real&#231;&#227;o com a presen&#231;a de gl&#243;bulos perif&#233;ricos&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> Como na faixa et&#225;ria pedi&#225;trica todos os nevos podem aumentar de tamanho com ou sem gl&#243;bulos perif&#233;ricos&#44; pode n&#227;o haver altera&#231;&#227;o significante no crescimento em rela&#231;&#227;o com a presen&#231;a de gl&#243;bulos perif&#233;ricos&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Em conclus&#227;o&#44; os padr&#245;es mais comuns foram o globular e o reticular em ordem decrescente no per&#237;odo pedi&#225;trico avaliado no presente estudo&#46; Foi observado que o padr&#227;o globular mudou para padr&#227;o homog&#234;neo&#47;globular homog&#234;neo no seguimento&#46; Embora gl&#243;bulos perif&#233;ricos sejam frequentes&#44; eles podem ser considerados um achado benigno nessa faixa et&#225;ria&#46; Conhecer as caracter&#237;sticas benignas e as altera&#231;&#245;es no padr&#227;o ajudar&#225; a diferenciar a les&#227;o benigna da les&#227;o maligna&#46; Estudos na faixa et&#225;ria pedi&#225;trica apoiados por MCR s&#227;o necess&#225;rios para elucidar a nevog&#234;nese&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Suporte financeiro</span><p id="par0090" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Contribui&#231;&#227;o dos autores</span><p id="par0095" class="elsevierStylePara elsevierViewall">Dilara Ilhan Erdil&#58; Contribui&#231;&#245;es substanciais na concep&#231;&#227;o e planejamento do estudo&#44; obten&#231;&#227;o de dados&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o na elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica de conte&#250;do intelectual importante&#44; revis&#227;o cr&#237;tica da literatura&#44; aprova&#231;&#227;o da vers&#227;o final a ser publicada&#44; garantia de que quest&#245;es relacionadas &#224; precis&#227;o ou integridade de qualquer parte do trabalho sejam adequadamente investigadas e resolvidas&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Ay&#351;e Esra Koku Aksu&#58; Contribui&#231;&#245;es substanciais na concep&#231;&#227;o e planejamento do estudo&#44; obten&#231;&#227;o de dados&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o na elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica de conte&#250;do intelectual importante&#44; revis&#227;o cr&#237;tica da literatura&#44; aprova&#231;&#227;o da vers&#227;o final a ser publicada&#44; garantia de que quest&#245;es relacionadas &#224; precis&#227;o ou integridade de qualquer parte do trabalho sejam adequadamente investigadas e resolvidas&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Asl&#305; Vefa Erdemir&#58; Obten&#231;&#227;o de dados&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o na elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final a ser publicada&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Duygu Erdil&#58; Obten&#231;&#227;o de dados&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o na elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final a ser publicada&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Cem Leblebici&#58; Obten&#231;&#227;o de dados&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o na elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final a ser publicada&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Asude Kara Polat&#58; Obten&#231;&#227;o de dados&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o na elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final a ser publicada&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflito de interesses</span><p id="par0125" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A inf&#226;ncia e a adolesc&#234;ncia s&#227;o per&#237;odos din&#226;micos em termos de nevog&#234;nese&#44; quando s&#227;o frequentemente observados o desenvolvimento e o crescimento de novos nevos melanoc&#237;ticos&#46; Este estudo objetivou examinar as altera&#231;&#245;es de padr&#227;o e di&#226;metro observadas no seguimento de nevos melanoc&#237;ticos pedi&#225;tricos&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Descrever as altera&#231;&#245;es de padr&#227;o e di&#226;metro observadas no seguimento de nevos melanoc&#237;ticos pedi&#225;tricos&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">O presente estudo envolveu a avalia&#231;&#227;o de 301 nevos melanoc&#237;ticos pedi&#225;tricos de 50 pacientes inscritos na <span class="elsevierStyleItalic">Dermatology Clinic of &#304;stanbul Training and Research Hospital</span> entre janeiro de 2008 e 2022&#46; Os nevos melanoc&#237;ticos pedi&#225;tricos foram diagnosticados cl&#237;nica e dermatoscopicamente&#46; Posteriormente&#44; foi realizado monitoramento videodermatosc&#243;pico desses nevos por um per&#237;odo de tr&#234;s meses a tr&#234;s anos&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Dos pacientes envolvidos no estudo&#44; 46&#37; eram do sexo feminino &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#41;&#44; com m&#233;dia de idade de 11&#44;5 anos&#46; Embora o padr&#227;o dermatosc&#243;pico dos nevos fosse globular em 40&#37; dos pacientes&#44; a taxa de padr&#227;o globular diminuiu para 30&#37; no seguimento&#46; O padr&#227;o basal de nevo homog&#234;neo foi encontrado em 10&#37; dos pacientes&#44; e em 13&#44;9&#37; no seguimento&#46; Gl&#243;bulos perif&#233;ricos foram observados em 19&#44;3&#37; dos casos mas&#44; no seguimento&#44; 61&#44;1&#37; dos gl&#243;bulos regrediram completamente&#46; Excis&#227;o do nevo foi indicada em apenas 11 dos 301 nevos&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Estudo unic&#234;ntrico e pequena quantidade de estudos dispon&#237;veis sobre o assunto&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Os nevos melanoc&#237;ticos pedi&#225;tricos podem apresentar altera&#231;&#245;es din&#226;micas em compara&#231;&#227;o aos nevos melanoc&#237;ticos em adultos&#46; Neste estudo&#44; foram avaliadas taxas de crescimento&#44; caracter&#237;sticas dermatosc&#243;picas e altera&#231;&#245;es de padr&#227;o observadas no seguimento de nevos melanoc&#237;ticos&#46; Padr&#227;o globular foi observado com maior frequ&#234;ncia&#46; A presen&#231;a de gl&#243;bulos perif&#233;ricos &#233; frequentemente observada em nevos pedi&#225;tricos&#44; sua regress&#227;o foi observada durante o per&#237;odo de seguimento&#46;</p></span>"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Homog&#234;neo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;10&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Homog&#234;neo &#43; reticular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sulcos paralelos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;4&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Reticular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;30&#44;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Padr&#227;o &#40;seguimento&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fibrilar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;2&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Globular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;30&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Globular &#43; homog&#234;neo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;7&#44;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Globular &#43; reticular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;4&#44;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Homog&#234;neo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;13&#44;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Homog&#234;neo &#43; reticular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;6&#44;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sulcos paralelos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;4&#44;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Reticular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;31&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Histopatologia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nevo composto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;18&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nevo displ&#225;sico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;54&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nevo juncional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;18&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nevo de Spitz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;9&#44;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de gl&#243;bulos perif&#233;ricos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;19&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">243&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;80&#44;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas dos gl&#243;bulos perif&#233;ricos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Circunferencial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;86&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Regular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;93&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>T&#237;pico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;94&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Evolu&#231;&#227;o dos gl&#243;bulos perif&#233;ricos</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Desapareceram&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;61&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sem altera&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;20&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diminu&#237;ram&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#44;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Aumentaram&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;5&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Desvio padr&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#177; 4&#44;60&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#177; 3&#44;38&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Globular &#43; homog&#234;neo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Homog&#234;neo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#177; 2&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Homog&#234;neo &#43; reticular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#177; 2&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sulcos paralelos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#177; 4&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Reticular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#177; 2&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab3706837.png"
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