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os receptores para retinoides s&#227;o amplamente expressos e a isotretino&#237;na pode potencialmente regular a express&#227;o de v&#225;rios genes neuronais&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A serotonina &#40;5&#8208;HT&#41; &#233; um neurotransmissor amplamente reconhecido e um mediador&#8208;chave do humor&#46; Desequil&#237;brios nos n&#237;veis de serotonina t&#234;m sido associados a humor deprimido e depress&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> O objetivo deste estudo piloto foi testar a hip&#243;tese de que o tratamento com isotretino&#237;na pode levar a mudan&#231;as mensur&#225;veis nos n&#237;veis de neurotransmissores&#8208;chave relacionados ao humor&#46; Para isso&#44; foi realizado um estudo de coorte prospectivo para avaliar os efeitos da isotretino&#237;na sobre os neurotransmissores serotonina &#40;5&#8208;HT&#41; 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                  \t\t\t\t\ttable-head\n
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          "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Resumo n&#227;o param&#233;trico dos achados para 5&#8208;HT &#40;HT&#41;&#44; 5&#8208;HIAA &#40;HA&#41; e sua raz&#227;o &#40;HTHA&#41; na linha basal &#40;0&#41;&#44; ap&#243;s dois meses &#40;2&#41; e quatro meses &#40;4&#41; de tratamento</p>"
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Carta ‐ Investigação
Efeitos da isotretinoína na serotonina: estudo piloto prospectivo em pacientes com acne
Adam P. Braya, Georgios Kravvasa,
Autor para correspondência
georgios.kravvas@nhs.net

Autor para correspondência.
, Suzanne M. Skevingtonb, Christopher R. Lovellc
a Bristol Dermatology Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, Reino Unido
b Manchester Centre for Health Psychology, School of Psychological Sciences, University of Manchester, Manchester, Reino Unido
c Kinghorn Dermatology Unit, Royal United Hospital, Bath, Reino Unido
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A isotretino&#237;na &#40;&#225;cido 13&#8208;cis retin&#243;ico&#41; &#233; um tratamento altamente eficaz e comumente utilizado contra a acne vulgar&#46; Embora a isotretino&#237;na tenha sido associada a humor deprimido&#44; depress&#227;o e idea&#231;&#227;o suicida&#44; uma associa&#231;&#227;o concreta a mudan&#231;as adversas de humor ainda n&#227;o foi comprovada&#44; com alguns estudos apoiando essa afirma&#231;&#227;o e outros refutando&#8208;a&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Como a isotretino&#237;na atravessa a barreira hematoencef&#225;lica&#44; um mecanismo biol&#243;gico ligando a isotretino&#237;na &#224; depress&#227;o &#233; plaus&#237;vel&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;7&#8211;10</span></a> No c&#233;rebro adulto&#44; os receptores para retinoides s&#227;o amplamente expressos e a isotretino&#237;na pode potencialmente regular a express&#227;o de v&#225;rios genes neuronais&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A serotonina &#40;5&#8208;HT&#41; &#233; um neurotransmissor amplamente reconhecido e um mediador&#8208;chave do humor&#46; Desequil&#237;brios nos n&#237;veis de serotonina t&#234;m sido associados a humor deprimido e depress&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> O objetivo deste estudo piloto foi testar a hip&#243;tese de que o tratamento com isotretino&#237;na pode levar a mudan&#231;as mensur&#225;veis nos n&#237;veis de neurotransmissores&#8208;chave relacionados ao humor&#46; Para isso&#44; foi realizado um estudo de coorte prospectivo para avaliar os efeitos da isotretino&#237;na sobre os neurotransmissores serotonina &#40;5&#8208;HT&#41; e 5&#8208;HIAA &#40;o principal metab&#243;lito da serotonina&#41; em pacientes com acne vulgar&#46; Os n&#237;veis plasm&#225;ticos de 5&#8208;HT e 5&#8208;HIAA foram medidos antes&#44; durante e ap&#243;s o tratamento com isotretino&#237;na&#46; Os dados foram coletados antes do in&#237;cio do tratamento&#44; aos dois e aos quatro meses de tratamento e um m&#234;s ap&#243;s o t&#233;rmino do tratamento&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Amostras de sangue de um total de 27 pacientes foram colhidas antes do in&#237;cio do tratamento&#46; Vinte e quatro e 22 pacientes foram submetidos a medidas no soro aos dois e aos quatro meses de tratamento&#44; respectivamente&#46; Apenas quatro pacientes compareceram para exames de sangue um m&#234;s ap&#243;s o t&#233;rmino do tratamento &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Na linha basal pr&#233;&#8208;tratamento&#44; foram encontrados os seguintes valores m&#233;dios&#58; 5&#8208;HT 10&#44;66 e 5&#8208;HIAA 74&#44;77&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Os valores m&#233;dios aos dois meses de tratamento foram&#58; 5&#8208;HT 9&#44;64 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;633&#41;&#44; 5&#8208;HIAA 44&#44;31 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;082&#41;&#46; Ap&#243;s quatro meses de terapia com isotretino&#237;na&#44; os valores foram&#58; 5&#8208;HT 13&#44;07 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;349&#41;&#44; 5&#8208;HIAA 32&#44;83 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;294&#41;&#46; Esses achados n&#227;o representaram mudan&#231;as estatisticamente significantes em rela&#231;&#227;o aos da linha basal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">O n&#250;mero decepcionantemente baixo de pacientes que compareceram &#224; consulta de seguimento um m&#234;s ap&#243;s a interrup&#231;&#227;o do tratamento n&#227;o possibilitou uma an&#225;lise estat&#237;stica significativa dos efeitos p&#243;s&#8208;isotretino&#237;na&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Um registro detalhado dos achados ao longo do tempo&#44; bem como as rela&#231;&#245;es de mudan&#231;a de HT para HIAA&#44; s&#227;o fornecidas na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">A rela&#231;&#227;o entre isotretino&#237;na e mudan&#231;as adversas de humor &#233; um aspecto altamente debatido da terapia com isotretino&#237;na&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">N&#227;o foi encontrada uma associa&#231;&#227;o significativa entre o tratamento com isotretino&#237;na e altera&#231;&#245;es nos neurotransmissores 5&#8208;HT&#44; 5&#8208;HIAA ou na rela&#231;&#227;o entre os dois&#46; Se houver uma liga&#231;&#227;o causal entre os dois&#44; &#233; prov&#225;vel que seja mediada por uma via neuroqu&#237;mica diferente&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Dito isso&#44; o presente estudo piloto tem um n&#250;mero pequeno de pacientes e uma perda significativa no seguimento&#46; Portanto&#44; mesmo que instrutivo&#44; o presente estudo n&#227;o pode apoiar totalmente essa afirma&#231;&#227;o&#46; Estudos maiores&#44; prospectivos e caso&#8208;controlados provavelmente ser&#227;o necess&#225;rios para abordar em detalhes a associa&#231;&#227;o entre humor&#44; isotretino&#237;na e neurotransmissores&#46; Espera&#8208;se que o presente estudo sirva de orienta&#231;&#227;o e inspira&#231;&#227;o para esses empreendimentos futuros&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0060" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0065" class="elsevierStylePara elsevierViewall">Adam P&#46; Bray&#58; Contribuiu para a concep&#231;&#227;o&#44; recrutamento&#44; gest&#227;o&#44; reda&#231;&#227;o e revis&#227;o da literatura associada a este estudo&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Georgios Kravvas&#58; Contribuiu para a concep&#231;&#227;o&#44; recrutamento&#44; gest&#227;o&#44; reda&#231;&#227;o e revis&#227;o da literatura associada a este estudo&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Suzanne M&#46; Skevington&#58; Contribuiu para a concep&#231;&#227;o&#44; recrutamento&#44; gest&#227;o&#44; reda&#231;&#227;o e revis&#227;o da literatura associada a este estudo&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Christopher R&#46; Lovell&#58; Contribuiu para a concep&#231;&#227;o&#44; recrutamento&#44; gest&#227;o&#44; reda&#231;&#227;o e revis&#227;o da literatura associada a este estudo&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0085" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Bray AP&#44; Kravvas G&#44; Skevington SM&#44; Lovell CR&#46; The effects of isotretinoin on serotonin&#58; a prospective pilot study on acne patients&#46; An Bras Dermatol&#46; 2022&#59;97&#58;526&#8211;8&#46;</p>"
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                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Resumo n&#227;o param&#233;trico dos achados para 5&#8208;HT &#40;HT&#41;&#44; 5&#8208;HIAA &#40;HA&#41; e sua raz&#227;o &#40;HTHA&#41; na linha basal &#40;0&#41;&#44; ap&#243;s dois meses &#40;2&#41; e quatro meses &#40;4&#41; de tratamento</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
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            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris&#58; A Case&#8208;Crossover Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Azoulay"
                            1 => "L&#46; Blais"
                            2 => "G&#46; Koren"
                            3 => "J&#46; Lelorier"
                            4 => "A&#46; Berard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4088/jcp.v69n0403"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Psychiatry&#46;"
                        "fecha" => "2008"
                        "volumen" => "69"
                        "paginaInicial" => "526"
                        "paginaFinal" => "532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18363422"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there an association between isotretinoin therapy and adverse mood changes&#63;&#46; A prospective study in a cohort of acne patients"
                      "autores" => array:1 [
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                            0 => "A&#46;P&#46; Bray"
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                            2 => "S&#46;M&#46; Skevington"
                            3 => "C&#46;R&#46; Lovell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dermatol Treat&#46;"
                        "fecha" => "2019"
                        "volumen" => "30"
                        "paginaInicial" => "796"
                        "paginaFinal" => "801"
                      ]
                    ]
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                    0 => array:2 [
                      "titulo" => "Isotretinoin and psychopathology&#58; a review"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46;P&#46; Kontaxakis"
                            1 => "D&#46; Skourides"
                            2 => "P&#46; Ferentinos"
                            3 => "B&#46;J&#46; Havaki-Kontaxaki"
                            4 => "G&#46;N&#46; Papadimitriou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1744-859X-8-2"
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Gen Psychiatry"
                        "fecha" => "2009"
                        "volumen" => "8"
                        "paginaInicial" => "2"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19154613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of suicide attempts with acne and treatment with isotretinoin&#58; retrospective Swedish cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Sundstr&#246;m"
                            1 => "L&#46; Alfredsson"
                            2 => "G&#46; Sj&#246;lin-Forsberg"
                            3 => "B&#46; Gerd&#233;n"
                            4 => "U&#46; Bergman"
                            5 => "J&#46; Jokinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.c5812"
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                        "tituloSerie" => "BMJ&#46;"
                        "fecha" => "2010"
                        "volumen" => "341"
                        "paginaInicial" => "c5812"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21071484"
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                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "5"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "H&#46;M&#46; Kremers"
                            2 => "C&#46; Vasilakis-Scaramozza"
                          ]
                        ]
                      ]
                    ]
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                        "tituloSerie" => "Arch Dermatol&#46;"
                        "fecha" => "2000"
                        "volumen" => "136"
                        "paginaInicial" => "1231"
                        "paginaFinal" => "1236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11030769"
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                0 => array:2 [
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                      "titulo" => "The psychological and emotional impact of acne and the effect of treatment with isotretinoin"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;C&#46; Kellett"
                            1 => "D&#46;J&#46; Gawkrodger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-2133.1999.02662.x"
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                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "1999"
                        "volumen" => "140"
                        "paginaInicial" => "273"
                        "paginaFinal" => "282"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10233222"
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                          "pii" => "S0301211517301689"
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              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The neurobiology of retinoic acid in affective disorders"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;D&#46; Bremner"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pnpbp.2007.07.001"
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                        "tituloSerie" => "Prog Neuropsychopharmacol Biol Psychiatry&#46;"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "315"
                        "paginaFinal" => "331"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17707566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                  ]
                ]
              ]
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              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Role of retinoid signaling in the adult brain"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;A&#46; Lane"
                            1 => "S&#46;J&#46; Bailey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pneurobio.2005.03.002"
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                        "tituloSerie" => "Prog Neurobiol&#46;"
                        "fecha" => "2005"
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                        "paginaFinal" => "293"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15882777"
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                    0 => array:2 [
                      "titulo" => "Significance of vitamin A to brain function&#44; behavior and learning"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;R&#46; Olson"
                            1 => "C&#46;V&#46; Mello"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mnfr.200900246"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Nutr Food Res&#46;"
                        "fecha" => "2010"
                        "volumen" => "54"
                        "paginaInicial" => "489"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20077419"
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              "identificador" => "bib0100"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "High expression of retinoic acid receptors and synthetic enzymes in the human hippocampus"
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                            2 => "A&#46; Sementilli"
                            3 => "L&#46;V&#46; de Carvalho"
                            4 => "P&#46;J&#46; McCaffery"
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                        "tituloSerie" => "Brain Struct Funct&#46;"
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                        "paginaInicial" => "473"
                        "paginaFinal" => "483"
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