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especialmente de genes relacionados a doen&#231;as autoimunes e inflamat&#243;rias&#44; al&#233;m de fatores ambientais&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;4</span></a> A literatura relata que v&#225;rios genes do sistema imunol&#243;gico contribuem para o desenvolvimento dessa doen&#231;a&#44; como o gene regulador autoimune &#40;AIRE&#41;&#44; ant&#237;geno leucocit&#225;rio humano &#40;HLA&#41;&#44; genes de interleucina &#40;IL&#41;&#44; ant&#237;geno 4 associado ao linf&#243;cito T citot&#243;xico &#40;CTLA4&#41;&#44; prote&#237;na tirosina fosfatase n&#227;o receptora 22 &#40;PTPN22&#41;&#44; fator de necrose tumoral da superfam&#237;lia 6 ou CD95 &#40;FAS&#41; e ligante FAS &#40;FASL&#41;&#44; entre outros&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">O CTLA4 &#40;2q34&#41; &#233; membro da superfam&#237;lia imunoglobulinas que codificam uma prote&#237;na que &#233; potente reguladora negativa da resposta das c&#233;lulas T&#46; Por seu papel na manuten&#231;&#227;o da toler&#226;ncia imunol&#243;gica&#44; ele tem sido apontado como um gene de suscetibilidade em doen&#231;as autoimunes humanas&#44;e apresenta v&#225;rios polimorfismos associados ao seu desenvolvimento&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> Entre os polimorfismos&#44; duas variantes gen&#233;ticas podem contribuir para a suscetibilidade ao AA&#58;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41;&#44; uma varia&#231;&#227;o <span class="elsevierStyleItalic">missense</span> que leva a uma substitui&#231;&#227;o do amino&#225;cido treonina por alanina no c&#243;don 17 no pept&#237;deo l&#237;der &#40;T17A&#41; e CT60 &#40;rs3087243&#41;&#44; localizada em 236<span class="elsevierStyleHsp" style=""></span>bp <span class="elsevierStyleItalic">downstream</span> no gene CTLA4 &#40;3&#8217;&#8208;UTR&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> No entanto&#44; estudos recentes feitos em diferentes popula&#231;&#245;es indicam que a rela&#231;&#227;o dessas variantes gen&#233;ticas no desenvolvimento de AA &#233; controversa&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">O presente estudo teve como objetivo determinar se as variantes dos genes CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; constituem um fator de predisposi&#231;&#227;o para AA em uma coorte de pacientes mexicanos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Sele&#231;&#227;o de pacientes e controles</span><p id="par0020" class="elsevierStylePara elsevierViewall">O estudo incluiu 50 indiv&#237;duos mexicanos com diagn&#243;stico de AA n&#227;o relacionados entre si &#40;32 mulheres e 18 homens&#59; idade m&#233;dia&#58; 30<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15 anos&#41; e 100 participantes saud&#225;veis &#40;59 mulheres e 41 homens&#59; idade m&#233;dia&#58; 25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8 anos&#41;&#59; os controles apresentavam hist&#243;ria familiar m&#233;dica negativa para doen&#231;as autoimunes&#47;inflamat&#243;rias&#46; Os pacientes foram recrutados no Departamento de Dermatologia ap&#243;s a aceita&#231;&#227;o e assinatura do termo de consentimento livre e esclarecido&#46; Este estudo foi aprovado pelo Comit&#234; de &#201;tica em Pesquisa e registrado sob o c&#243;digo DE09&#8208;001&#46; Detalhes adicionais sobre as caracter&#237;sticas cl&#237;nicas e demogr&#225;ficas&#44; tipo de AA e distribui&#231;&#227;o de cada paciente foram obtidos durante a avalia&#231;&#227;o cl&#237;nica&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Isolamento e genotipagem de DNA</span><p id="par0025" class="elsevierStylePara elsevierViewall">O DNA gen&#244;mico foi isolado do sangue venoso perif&#233;rico com o m&#233;todo <span class="elsevierStyleItalic">salting out</span> e suspenso em Tris&#8208;EDTA &#40;pH 7&#44;8&#41; a uma concentra&#231;&#227;o final de 0&#44;1 a 1&#44;0<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;&#956;L antes do uso&#46; As frequ&#234;ncias genot&#237;picas e al&#233;licas das variantes do gene CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; foram caracterizadas por PCR&#8208;RFLP com um termociclador MJ Mini PTC1148 &#40;Bio&#8208;Rad&#44; Hercules&#59; CA&#44; Estados Unidos&#41;&#44; <span class="elsevierStyleItalic">primers</span> oligonucleot&#237;dicos espec&#237;ficos &#40;IDT&#44; Coralville&#44; IA&#44; Estados Unidos&#41; e enzimas de restri&#231;&#227;o &#40;New England Biolabs&#44; Ipswich&#44; MA&#44; Estados Unidos&#41; de acordo com um protocolo publicado anteriormente&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> Os fragmentos obtidos foram analisados por eletroforese em gel de agarose a 2&#44;5&#37; com brometo de et&#237;dio&#44; observados no transiluminador UVP modelo 2UV de alto desempenho &#40;Upland&#44; CA&#44; E&#41; e documentados&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">An&#225;lise estat&#237;stica</span><p id="par0030" class="elsevierStylePara elsevierViewall">Para an&#225;lise gen&#233;tica&#44; o tamanho da amostra foi calculado com base na incid&#234;ncia mundial de AA de 2&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> assumiu&#8208;se um poder de 99&#44;0&#37; &#40;um valor&#8208;Z de 2&#44;33&#41;&#44; foi obtido o n&#250;mero m&#237;nimo de 43 indiv&#237;duos&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">O <span class="elsevierStyleItalic">software</span> SPSS v21&#46;0 para Windows &#40;SPSS&#44; Inc&#46; Chicago&#44; IL&#44; Estados Unidos&#41; e o programa estat&#237;stico Epi&#8208;INFO<span class="elsevierStyleSup">TM</span> 7 &#40;Stone&#46; Mountain&#44; GA&#44; USD Inc&#41; foram usados para an&#225;lise dos dados&#46; O equil&#237;brio de Hardy&#8208;Weinberg para os alelos foi obtido por meio de um teste de qualidade de ajuste e a depend&#234;ncia genot&#237;pica entre pacientes e controles foi determinada com um teste de &#967;<span class="elsevierStyleSup">2</span>&#46; A raz&#227;o de probabilidades &#40;OR&#41; foi calculada a partir de tabelas de conting&#234;ncia 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2 &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Resultados</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Caracter&#237;sticas cl&#237;nicas dos participantes</span><p id="par0040" class="elsevierStylePara elsevierViewall">O presente estudo analisou a distribui&#231;&#227;o do gen&#243;tipo e a frequ&#234;ncia al&#233;lica das variantes do gene CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG e CT60&#46; O universo do estudo &#40;n&#41; consistiu em 50 pacientes com AA e 100 controles&#46; A apresenta&#231;&#227;o cl&#237;nica da AA nos pacientes foi&#58; 41 pacientes com AA em placas &#40;unifocal n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#44; oito mulheres e seis homens&#59; multifocal n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44; 19 mulheres e 8 homens&#41;&#44; quatro pacientes com AA ofi&#225;sica &#40;tr&#234;s mulheres e um homem&#41;&#44; uma mulher com AA total e quatro pacientes com AA universal &#40;tr&#234;s homens e um mulher&#41;&#46; Dez pacientes &#40;20&#37;&#41; tinham hist&#243;rico pessoal de doen&#231;as autoimunes &#40;vitiligo&#44; diabetes melito tipo 2&#44; entre outros&#41; e 36 indiv&#237;duos &#40;72&#37;&#41; tinham hist&#243;rico familiar de doen&#231;a imunol&#243;gica&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">An&#225;lise de alelos e gen&#243;tipos</span><p id="par0045" class="elsevierStylePara elsevierViewall">V&#225;rios testes foram feitos para ambas as variantes gen&#233;ticas&#44; a fim de avaliar o equil&#237;brio de Hardy&#8208;Weinberg &#40;EHW&#59; <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#44; todos com p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; indicaram que as variantes dos genes rs231775 e rs3087243 estavam em EHW nos pacientes com AA e controles&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Os alelos e gen&#243;tipos do CTLA4 rs231775 e do rs3087243 do grupo controle foram comparados com os dos indiv&#237;duos com AA &#40;todos os tipos de AA&#41; e com os diferentes tipos de AA&#59; a <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> apresenta os resultados dessa compara&#231;&#227;o&#46; Para CTLA4 rs231775&#44; 30&#37; dos pacientes com AA apresentaram gen&#243;tipo AA do tipo selvagem homozig&#243;tico&#44; 48&#37; apresentaram o gen&#243;tipo AG heterozig&#243;tico e os 22&#37; restantes&#44; gen&#243;tipo GG variante homozig&#243;tica&#46; Para CTLA4 rs3087243&#44; 44&#37; dos pacientes com AA apresentaram o gen&#243;tipo GG do tipo selvagem homozig&#243;tico&#44; 44&#37; apresentaram o gen&#243;tipo AG heterozig&#243;tico e os 12&#37; restantes&#44; AA variante homozig&#243;tica&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Associa&#231;&#227;o dos gen&#243;tipos em pacientes com alopecia areata</span><p id="par0055" class="elsevierStylePara elsevierViewall">Quando os gen&#243;tipos e frequ&#234;ncias de alelos CTLA4 rs231775 e rs3087243 foram comparados entre toda a coorte &#40;todos os tipos de AA&#41; e controles&#44; observou&#8208;se que o gen&#243;tipo AG heterozig&#243;tico para CTLA4 rs231775 e rs3087243 era mais frequente nos controles do que em todos os grupos de pacientes com AA&#46; Al&#233;m disso&#44; n&#227;o se observou associa&#231;&#227;o entre variantes al&#233;licas e AA nos pacientes analisados &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46; Al&#233;m disso&#44; n&#227;o foi encontrada rela&#231;&#227;o entre o gen&#243;tipo e o tipo de AA com a hist&#243;ria pessoal&#47;familiar de doen&#231;as autoimunes ou o sexo dos pacientes analisados &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discuss&#227;o</span><p id="par0060" class="elsevierStylePara elsevierViewall">AA &#233; doen&#231;a autoimune com perda de cabelos que tem sido associada a m&#250;ltiplas variantes gen&#233;ticas&#44; v&#225;rias das quais participam de vias de resposta imune relacionadas ao HLA&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> O produto do gene CTLA4 &#233; um receptor expresso pelas c&#233;lulas T CD4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>e CD8<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#46; Experimentos em camundongos <span class="elsevierStyleItalic">knockout</span> demonstraram o importante papel que o CTLA4 desempenha na prote&#231;&#227;o contra a autoimunidade&#46; O CTLA&#8208;4 &#233; um regulador negativo cr&#237;tico das respostas das c&#233;lulas T e sua a&#231;&#227;o nas c&#233;lulas Treg pode controlar a atividade de outras c&#233;lulas e a autoimunidade fatal&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Foi sugerida a associa&#231;&#227;o entre a presen&#231;a das variantes do gene CTLA4 e o desenvolvimento de diferentes doen&#231;as autoimunes&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#44;15</span></a> No entanto&#44; nas doen&#231;as imunol&#243;gicas dermatol&#243;gicas&#44; os resultados s&#227;o controversos&#59; no vitiligo&#44; a literatura relata tanto sua participa&#231;&#227;o como n&#227;o influ&#234;ncia&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> Uma situa&#231;&#227;o semelhante foi observada no desenvolvimento da psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Nesse sentido&#44; considerando a poss&#237;vel contribui&#231;&#227;o da fun&#231;&#227;o autoimune na alopecia&#44; estudos de variantes gen&#233;ticas do gene CTLA4 foram conduzidos em diversas popula&#231;&#245;es&#46; Uma an&#225;lise anterior dessa associa&#231;&#227;o sugeriu o poss&#237;vel envolvimento das variantes do gene CTLA4 como fator de risco no desenvolvimento de AA em uma popula&#231;&#227;o europeia&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> com efeito mais forte em pacientes com formas acentuadas da doen&#231;a&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Outro estudo feito em uma popula&#231;&#227;o italiana&#44; no qual foram analisadas as variantes dos genes rs231775 e rs3087243&#44; apontou esse &#250;ltimo como fator de risco no desenvolvimento de AA em placas&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> Por outro lado&#44; estudo feito no Ir&#227; n&#227;o conseguiu provar a associa&#231;&#227;o da variante do gene rs3087243 no desenvolvimento de AA&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Em estudo anterior&#44; os autores observaram a participa&#231;&#227;o de variantes gen&#233;ticas de TNF&#945; e PTPN22<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> como fator de risco para AA em pacientes mexicanos&#59; a fun&#231;&#227;o de ambos os genes est&#225; relacionada &#224; regula&#231;&#227;o dos mecanismos imunol&#243;gicos&#46; No entanto&#44; a participa&#231;&#227;o das variantes gen&#233;ticas do CTLA4 na AA n&#227;o foi analisada nessa popula&#231;&#227;o&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Alguns SNPs dentro do gene CTLA&#8208;4 j&#225; foram analisados quanto &#224; suscetibilidade &#224; artrite reumatoide &#40;AR&#41; na popula&#231;&#227;o mexicana&#59; entre eles&#44; rs5742909&#44; rs231775 e rs3087243&#59; sugere&#8208;se que o hapl&#243;tipo &#8208;319C&#47;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49G&#47;CT60G do gene CTLA&#8208;4 &#233; fator de risco para AR&#44; enquanto que o SNP rs3087243 pode ser fator protetor contra esse tipo de doen&#231;a autoimune&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">No entanto&#44; n&#227;o foram observadas diferen&#231;as significativas para rs231775 e rs3087243 no presente estudo &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#44; sugeriu&#8208;se que essas variantes n&#227;o s&#227;o fator de risco no desenvolvimento de AA ou de AA em placas na popula&#231;&#227;o mexicana&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclus&#227;o</span><p id="par0095" class="elsevierStylePara elsevierViewall">As variantes gen&#233;ticas rs231775 e rs3087243 do gene CTLA4 n&#227;o constituem fator de risco no desenvolvimento de AA na popula&#231;&#227;o mexicana de Monterrey&#44; M&#233;xico&#46; Al&#233;m disso&#44; essas variantes gen&#233;ticas n&#227;o apresentam associa&#231;&#227;o com antecedentes familiares&#47;pessoais de doen&#231;as autoimunes ou com o g&#234;nero dos sujeitos do estudo&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Suporte financeiro</span><p id="par0100" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Contribui&#231;&#227;o dos autores</span><p id="par0105" class="elsevierStylePara elsevierViewall">Mauricio Andr&#233;s Salinas Santander&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Cristina Susana Cantu&#8208;Salinas&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Jorge Ocampo&#8208;Candiani&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Victor de Jesus Suarez&#8208;Valencia&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Jennifer Guadalupe Ramirez&#8208;Guerrero&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Celia Nohemi Sanchez&#8208;Dominguez&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflitos de interesse</span><p id="par0135" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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            0 => "Alopecia areata"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar9030" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata &#233; doen&#231;a autoimune que causa perda de cabelo sem cicatrizes na les&#227;o&#46; As variantes gen&#233;ticas do gene do ant&#237;geno 4 associado ao linf&#243;cito T citot&#243;xico &#40;CTLA4&#41;&#44; um regulador negativo da resposta das c&#233;lulas T&#44; foram associadas a predisposi&#231;&#227;o a doen&#231;as autoimunes em diferentes popula&#231;&#245;es&#59; no entanto&#44; o envolvimento dessas variantes gen&#233;ticas no desenvolvimento da alopecia areata &#233; controverso&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Avaliar a associa&#231;&#227;o potencial de duas variantes do gene CTLA4 e alopecia areata em uma popula&#231;&#227;o mexicana&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Foram genotipadas por PCR&#8208;RFLP as variantes<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; de 50 pacientes com alopecia areata e 100 controles saud&#225;veis&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">N&#227;o foi observada diferen&#231;a estat&#237;stica para alguma das variantes gen&#233;ticas quanto &#224;s frequ&#234;ncias al&#233;licas ou genot&#237;picas entre os pacientes com alopecia areata e controles quando considerados os par&#226;metros de hist&#243;ria familiar&#47;pessoal de doen&#231;as autoimunes ou sexo &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Amostra pequena de pacientes e coleta de dados em apenas uma popula&#231;&#227;o do nordeste do M&#233;xico&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">As variantes gen&#233;ticas rs231775 e rs3087243 do gene CTLA4 n&#227;o s&#227;o um fator de risco para o desenvolvimento de alopecia areata na popula&#231;&#227;o mexicana analisada&#46;</p></span>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Salinas&#8208;Santander MA&#44; Cantu&#8208;Salinas CS&#44; Ocampo&#8208;Candiani J&#44; Suarez&#8208;Valencia VJ&#44; Ramirez&#8208;Guerrero JG&#44; Sanchez&#8208;Dominguez CN&#46; CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; and CT60 &#40;rs3087243&#41; gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico&#46; An Bras Dermatol&#46; 2020&#59;95&#58;283&#8211;8&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Trabalho realizado no Departamento de Investiga&#231;&#227;o&#44; Faculdade de Medicina da Universidade de Saltillo&#44; Universidade Aut&#244;noma de Coahuila&#44; Saltillo&#44; Coahuila&#44; M&#233;xico e Servi&#231;o de Dermatologia&#44; Hospital Universit&#225;rio Dr&#46; Jos&#233; Eleuterio Gonz&#225;lez&#44; Faculdade de Medicina&#44; Universidade Aut&#244;noma de Nuevo Le&#243;n&#44; Nuevo Le&#243;n&#44; M&#233;xico&#46;</p>"
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                  """
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          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise das variantes gen&#233;ticas CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; por sexo e hist&#243;ria pessoal&#47;familiar de doen&#231;as autoimunes</p>"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polymorphism of FAS and FAS Ligand Genes in Alopecia Areata&#58; A Case&#8208;control Study in Egyptian Population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Seleit"
                            1 => "O&#46;A&#46; Bakry"
                            2 => "E&#46;A&#46;E&#46; Gayed"
                            3 => "A&#46;E&#46;D&#46; Gawad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/ijd.IJD_286_17"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "63"
                        "paginaInicial" => "220"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29937558"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Deletion of CTLA&#8208;4 on regulatory T cells during adulthood leads to resistance to autoimmunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Paterson"
                            1 => "S&#46;B&#46; Lovitch"
                            2 => "P&#46;T&#46; Sage"
                            3 => "V&#46;R&#46; Juneja"
                            4 => "Y&#46; Lee"
                            5 => "J&#46;D&#46; Trombley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20141030"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "212"
                        "paginaInicial" => "1603"
                        "paginaFinal" => "1621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26371185"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic variants in CTLA4 are strongly associated with alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;K&#46; John"
                            1 => "F&#46;F&#46; Brockschmidt"
                            2 => "S&#46; Redler"
                            3 => "C&#46; Herold"
                            4 => "S&#46; Hanneken"
                            5 => "S&#46; Eigelshoven"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2010.427"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "131"
                        "paginaInicial" => "1169"
                        "paginaFinal" => "1172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21346773"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytotoxic T&#8208;lymphocyte antigen 4 &#40;CTLA4&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG and CT60 gene polymorphisms in Alopecia Areata&#58; a case&#8208;control association study in the Italian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Megiorni"
                            1 => "B&#46; Mora"
                            2 => "C&#46; Maxia"
                            3 => "M&#46; Gerardi"
                            4 => "A&#46; Pizzuti"
                            5 => "A&#46; Rossi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00403-013-1348-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res&#46;"
                        "fecha" => "2013"
                        "volumen" => "305"
                        "paginaInicial" => "665"
                        "paginaFinal" => "670"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23567921"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in northern Chinese population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Sun"
                            1 => "Y&#46; Meng"
                            2 => "Y&#46; Xie"
                            3 => "H&#46; Zhang"
                            4 => "Z&#46; Zhang"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0101986"
                      "Revista" => array:5 [
                        "tituloSerie" => "PloS One&#46;"
                        "fecha" => "2014"
                        "volumen" => "9"
                        "paginaInicial" => "e101986"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25003519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and burden of alopecia areata&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;C&#46; Villasante Fricke"
                            1 => "M&#46; Miteva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/CCID.S53985"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cosmet Investig Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "8"
                        "paginaInicial" => "397"
                        "paginaFinal" => "403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26244028"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genome&#8208;wide meta&#8208;analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Betz"
                            1 => "L&#46; Petukhova"
                            2 => "S&#46; Ripke"
                            3 => "H&#46; Huang"
                            4 => "A&#46; Menelaou"
                            5 => "S&#46; Redler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Nat Commun&#46;"
                        "fecha" => "2015"
                        "volumen" => "6"
                        "paginaInicial" => "5966"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA&#8208;4&#58; a moving target in immunotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Rowshanravan"
                            1 => "N&#46; Halliday"
                            2 => "D&#46;M&#46; Sansom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2017-06-741033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood&#46;"
                        "fecha" => "2018"
                        "volumen" => "131"
                        "paginaInicial" => "58"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29118008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA&#8208;4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49 G&#47;A Polymorphism Confers Autoimmune Disease Risk&#58; An Updated Meta&#8208;Analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Wang"
                            1 => "Q&#46; Zhu"
                            2 => "Y&#46; Lu"
                            3 => "H&#46; Lu"
                            4 => "F&#46; Zhang"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/gtmb.2016.0335"
                      "Revista" => array:6 [
                        "tituloSerie" => "Genet Test Mol Biomarkers&#46;"
                        "fecha" => "2017"
                        "volumen" => "21"
                        "paginaInicial" => "222"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28384040"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of Cytotoxic T&#8208;Lymphocyte&#8208;Associated Protein 4 &#40;CTLA4&#41; Gene Polymorphisms with Autoimmune Thyroid Disease in Children and Adults&#58; Case&#8208;Control Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;H&#46; Ting"
                            1 => "M&#46;N&#46; Chien"
                            2 => "F&#46;S&#46; Lo"
                            3 => "C&#46;H&#46; Wang"
                            4 => "C&#46;Y&#46; Huang"
                            5 => "C&#46;L&#46; Lin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0154394"
                      "Revista" => array:5 [
                        "tituloSerie" => "PloS one&#46;"
                        "fecha" => "2016"
                        "volumen" => "11"
                        "paginaInicial" => "e0154394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27111218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA&#8208;4 A49G gene polymorphism is not associated with vitiligo in South Indian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Deeba"
                            1 => "R&#46; Syed"
                            2 => "J&#46; Quareen"
                            3 => "M&#46;A&#46; Waheed"
                            4 => "K&#46; Jamil"
                            5 => "H&#46; Rao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0019-5154.60347"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Dermatol&#46;"
                        "fecha" => "2010"
                        "volumen" => "55"
                        "paginaInicial" => "29"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20418973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between cytotoxic T&#8208;lymphocyte antigen&#8208;4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49A&#47;G polymorphism and psoriasis and vitiligo&#58; A meta&#8208;analysis of case&#8208;control studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Liang"
                            1 => "S&#46; Zhang"
                            2 => "Q&#46; Luo"
                            3 => "W&#46; Li"
                            4 => "X&#46; Tian"
                            5 => "F&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.gene.2015.05.051"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gene&#46;"
                        "fecha" => "2015"
                        "volumen" => "568"
                        "paginaInicial" => "196"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26013045"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of Cytotoxic T Lymphocyte Antigen&#8208;4 Gene Polymorphisms with Psoriasis Vulgaris&#58; A Case&#8208;Control Study in Turkish Population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46;G&#46; Dursun"
                            1 => "H&#46;O&#46; Yilmaz"
                            2 => "R&#46; Dursun"
                            3 => "S&#46; Kulaksizoglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2018/1643906"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol Res&#46;"
                        "fecha" => "2018"
                        "volumen" => "2018"
                        "paginaInicial" => "1643906"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29850619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between PTPN22 C1858T polymorphism and alopecia areata risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Salinas-Santander"
                            1 => "C&#46; Sanchez-Dominguez"
                            2 => "C&#46; Cantu-Salinas"
                            3 => "H&#46; Gonzalez-Cardenas"
                            4 => "A&#46;C&#46; Cepeda-Nieto"
                            5 => "R&#46;M&#46; Cerda-Flores"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3892/etm.2015.2728"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Ther Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "10"
                        "paginaInicial" => "1953"
                        "paginaFinal" => "1958"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26640579"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "20"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The &#8208;319C&#47;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49G&#47;CT60G haplotype of CTLA&#8208;4 gene confers susceptibility to rheumatoid arthritis in Mexican population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Torres-Carrillo"
                            1 => "H&#46; Ontiveros-Mercado"
                            2 => "N&#46;M&#46; Torres-Carrillo"
                            3 => "I&#46; Parra-Rojas"
                            4 => "H&#46; Rangel-Villalobos"
                            5 => "M&#46;G&#46; Ramirez-Duenas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12013-013-9640-6"
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                        "tituloSerie" => "Cell Biochem Biophys&#46;"
                        "fecha" => "2013"
                        "volumen" => "67"
                        "paginaInicial" => "1217"
                        "paginaFinal" => "1228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23703660"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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Investigação
As variantes do gene CTLA4+49AG (rs231775) e CT60 (rs3087243) não estão associadas à alopecia areata em população mexicana de Monterrey, México
Mauricio Andrés Salinas‐Santandera,
Autor para correspondência
msalinsa@yahoo.com

Autor para correspondência.
, Cristina Susana Cantu‐Salinasb, Jorge Ocampo‐Candianib, Victor de Jesus Suarez‐Valenciaa, Jennifer Guadalupe Ramirez‐Guerreroa, Celia Nohemi Sanchez‐Dominguezc
a Departamento de Investigação, Faculdade de Medicina da Universidade de Saltillo, Universidade Autônoma de Coahuila, Saltillo, México
b Serviço de Dermatologia, Hospital Universitário Dr. José Eleuterio González, Universidade Autônoma de Nuevo León, Monterrey, México
c Departamento de Bioquímica e Medicina Molecular, Faculdade de Medicina, Universidade Autônoma de Nuevo León, Nuevo León, México
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especialmente de genes relacionados a doen&#231;as autoimunes e inflamat&#243;rias&#44; al&#233;m de fatores ambientais&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;4</span></a> A literatura relata que v&#225;rios genes do sistema imunol&#243;gico contribuem para o desenvolvimento dessa doen&#231;a&#44; como o gene regulador autoimune &#40;AIRE&#41;&#44; ant&#237;geno leucocit&#225;rio humano &#40;HLA&#41;&#44; genes de interleucina &#40;IL&#41;&#44; ant&#237;geno 4 associado ao linf&#243;cito T citot&#243;xico &#40;CTLA4&#41;&#44; prote&#237;na tirosina fosfatase n&#227;o receptora 22 &#40;PTPN22&#41;&#44; fator de necrose tumoral da superfam&#237;lia 6 ou CD95 &#40;FAS&#41; e ligante FAS &#40;FASL&#41;&#44; entre outros&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">O CTLA4 &#40;2q34&#41; &#233; membro da superfam&#237;lia imunoglobulinas que codificam uma prote&#237;na que &#233; potente reguladora negativa da resposta das c&#233;lulas T&#46; Por seu papel na manuten&#231;&#227;o da toler&#226;ncia imunol&#243;gica&#44; ele tem sido apontado como um gene de suscetibilidade em doen&#231;as autoimunes humanas&#44;e apresenta v&#225;rios polimorfismos associados ao seu desenvolvimento&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> Entre os polimorfismos&#44; duas variantes gen&#233;ticas podem contribuir para a suscetibilidade ao AA&#58;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41;&#44; uma varia&#231;&#227;o <span class="elsevierStyleItalic">missense</span> que leva a uma substitui&#231;&#227;o do amino&#225;cido treonina por alanina no c&#243;don 17 no pept&#237;deo l&#237;der &#40;T17A&#41; e CT60 &#40;rs3087243&#41;&#44; localizada em 236<span class="elsevierStyleHsp" style=""></span>bp <span class="elsevierStyleItalic">downstream</span> no gene CTLA4 &#40;3&#8217;&#8208;UTR&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> No entanto&#44; estudos recentes feitos em diferentes popula&#231;&#245;es indicam que a rela&#231;&#227;o dessas variantes gen&#233;ticas no desenvolvimento de AA &#233; controversa&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">O presente estudo teve como objetivo determinar se as variantes dos genes CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; constituem um fator de predisposi&#231;&#227;o para AA em uma coorte de pacientes mexicanos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Sele&#231;&#227;o de pacientes e controles</span><p id="par0020" class="elsevierStylePara elsevierViewall">O estudo incluiu 50 indiv&#237;duos mexicanos com diagn&#243;stico de AA n&#227;o relacionados entre si &#40;32 mulheres e 18 homens&#59; idade m&#233;dia&#58; 30<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15 anos&#41; e 100 participantes saud&#225;veis &#40;59 mulheres e 41 homens&#59; idade m&#233;dia&#58; 25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8 anos&#41;&#59; os controles apresentavam hist&#243;ria familiar m&#233;dica negativa para doen&#231;as autoimunes&#47;inflamat&#243;rias&#46; Os pacientes foram recrutados no Departamento de Dermatologia ap&#243;s a aceita&#231;&#227;o e assinatura do termo de consentimento livre e esclarecido&#46; Este estudo foi aprovado pelo Comit&#234; de &#201;tica em Pesquisa e registrado sob o c&#243;digo DE09&#8208;001&#46; Detalhes adicionais sobre as caracter&#237;sticas cl&#237;nicas e demogr&#225;ficas&#44; tipo de AA e distribui&#231;&#227;o de cada paciente foram obtidos durante a avalia&#231;&#227;o cl&#237;nica&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Isolamento e genotipagem de DNA</span><p id="par0025" class="elsevierStylePara elsevierViewall">O DNA gen&#244;mico foi isolado do sangue venoso perif&#233;rico com o m&#233;todo <span class="elsevierStyleItalic">salting out</span> e suspenso em Tris&#8208;EDTA &#40;pH 7&#44;8&#41; a uma concentra&#231;&#227;o final de 0&#44;1 a 1&#44;0<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;&#956;L antes do uso&#46; As frequ&#234;ncias genot&#237;picas e al&#233;licas das variantes do gene CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; foram caracterizadas por PCR&#8208;RFLP com um termociclador MJ Mini PTC1148 &#40;Bio&#8208;Rad&#44; Hercules&#59; CA&#44; Estados Unidos&#41;&#44; <span class="elsevierStyleItalic">primers</span> oligonucleot&#237;dicos espec&#237;ficos &#40;IDT&#44; Coralville&#44; IA&#44; Estados Unidos&#41; e enzimas de restri&#231;&#227;o &#40;New England Biolabs&#44; Ipswich&#44; MA&#44; Estados Unidos&#41; de acordo com um protocolo publicado anteriormente&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> Os fragmentos obtidos foram analisados por eletroforese em gel de agarose a 2&#44;5&#37; com brometo de et&#237;dio&#44; observados no transiluminador UVP modelo 2UV de alto desempenho &#40;Upland&#44; CA&#44; E&#41; e documentados&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">An&#225;lise estat&#237;stica</span><p id="par0030" class="elsevierStylePara elsevierViewall">Para an&#225;lise gen&#233;tica&#44; o tamanho da amostra foi calculado com base na incid&#234;ncia mundial de AA de 2&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> assumiu&#8208;se um poder de 99&#44;0&#37; &#40;um valor&#8208;Z de 2&#44;33&#41;&#44; foi obtido o n&#250;mero m&#237;nimo de 43 indiv&#237;duos&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">O <span class="elsevierStyleItalic">software</span> SPSS v21&#46;0 para Windows &#40;SPSS&#44; Inc&#46; Chicago&#44; IL&#44; Estados Unidos&#41; e o programa estat&#237;stico Epi&#8208;INFO<span class="elsevierStyleSup">TM</span> 7 &#40;Stone&#46; Mountain&#44; GA&#44; USD Inc&#41; foram usados para an&#225;lise dos dados&#46; O equil&#237;brio de Hardy&#8208;Weinberg para os alelos foi obtido por meio de um teste de qualidade de ajuste e a depend&#234;ncia genot&#237;pica entre pacientes e controles foi determinada com um teste de &#967;<span class="elsevierStyleSup">2</span>&#46; A raz&#227;o de probabilidades &#40;OR&#41; foi calculada a partir de tabelas de conting&#234;ncia 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2 &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Resultados</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Caracter&#237;sticas cl&#237;nicas dos participantes</span><p id="par0040" class="elsevierStylePara elsevierViewall">O presente estudo analisou a distribui&#231;&#227;o do gen&#243;tipo e a frequ&#234;ncia al&#233;lica das variantes do gene CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG e CT60&#46; O universo do estudo &#40;n&#41; consistiu em 50 pacientes com AA e 100 controles&#46; A apresenta&#231;&#227;o cl&#237;nica da AA nos pacientes foi&#58; 41 pacientes com AA em placas &#40;unifocal n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#44; oito mulheres e seis homens&#59; multifocal n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44; 19 mulheres e 8 homens&#41;&#44; quatro pacientes com AA ofi&#225;sica &#40;tr&#234;s mulheres e um homem&#41;&#44; uma mulher com AA total e quatro pacientes com AA universal &#40;tr&#234;s homens e um mulher&#41;&#46; Dez pacientes &#40;20&#37;&#41; tinham hist&#243;rico pessoal de doen&#231;as autoimunes &#40;vitiligo&#44; diabetes melito tipo 2&#44; entre outros&#41; e 36 indiv&#237;duos &#40;72&#37;&#41; tinham hist&#243;rico familiar de doen&#231;a imunol&#243;gica&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">An&#225;lise de alelos e gen&#243;tipos</span><p id="par0045" class="elsevierStylePara elsevierViewall">V&#225;rios testes foram feitos para ambas as variantes gen&#233;ticas&#44; a fim de avaliar o equil&#237;brio de Hardy&#8208;Weinberg &#40;EHW&#59; <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#44; todos com p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; indicaram que as variantes dos genes rs231775 e rs3087243 estavam em EHW nos pacientes com AA e controles&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Os alelos e gen&#243;tipos do CTLA4 rs231775 e do rs3087243 do grupo controle foram comparados com os dos indiv&#237;duos com AA &#40;todos os tipos de AA&#41; e com os diferentes tipos de AA&#59; a <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> apresenta os resultados dessa compara&#231;&#227;o&#46; Para CTLA4 rs231775&#44; 30&#37; dos pacientes com AA apresentaram gen&#243;tipo AA do tipo selvagem homozig&#243;tico&#44; 48&#37; apresentaram o gen&#243;tipo AG heterozig&#243;tico e os 22&#37; restantes&#44; gen&#243;tipo GG variante homozig&#243;tica&#46; Para CTLA4 rs3087243&#44; 44&#37; dos pacientes com AA apresentaram o gen&#243;tipo GG do tipo selvagem homozig&#243;tico&#44; 44&#37; apresentaram o gen&#243;tipo AG heterozig&#243;tico e os 12&#37; restantes&#44; AA variante homozig&#243;tica&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Associa&#231;&#227;o dos gen&#243;tipos em pacientes com alopecia areata</span><p id="par0055" class="elsevierStylePara elsevierViewall">Quando os gen&#243;tipos e frequ&#234;ncias de alelos CTLA4 rs231775 e rs3087243 foram comparados entre toda a coorte &#40;todos os tipos de AA&#41; e controles&#44; observou&#8208;se que o gen&#243;tipo AG heterozig&#243;tico para CTLA4 rs231775 e rs3087243 era mais frequente nos controles do que em todos os grupos de pacientes com AA&#46; Al&#233;m disso&#44; n&#227;o se observou associa&#231;&#227;o entre variantes al&#233;licas e AA nos pacientes analisados &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46; Al&#233;m disso&#44; n&#227;o foi encontrada rela&#231;&#227;o entre o gen&#243;tipo e o tipo de AA com a hist&#243;ria pessoal&#47;familiar de doen&#231;as autoimunes ou o sexo dos pacientes analisados &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discuss&#227;o</span><p id="par0060" class="elsevierStylePara elsevierViewall">AA &#233; doen&#231;a autoimune com perda de cabelos que tem sido associada a m&#250;ltiplas variantes gen&#233;ticas&#44; v&#225;rias das quais participam de vias de resposta imune relacionadas ao HLA&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> O produto do gene CTLA4 &#233; um receptor expresso pelas c&#233;lulas T CD4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>e CD8<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#46; Experimentos em camundongos <span class="elsevierStyleItalic">knockout</span> demonstraram o importante papel que o CTLA4 desempenha na prote&#231;&#227;o contra a autoimunidade&#46; O CTLA&#8208;4 &#233; um regulador negativo cr&#237;tico das respostas das c&#233;lulas T e sua a&#231;&#227;o nas c&#233;lulas Treg pode controlar a atividade de outras c&#233;lulas e a autoimunidade fatal&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Foi sugerida a associa&#231;&#227;o entre a presen&#231;a das variantes do gene CTLA4 e o desenvolvimento de diferentes doen&#231;as autoimunes&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#44;15</span></a> No entanto&#44; nas doen&#231;as imunol&#243;gicas dermatol&#243;gicas&#44; os resultados s&#227;o controversos&#59; no vitiligo&#44; a literatura relata tanto sua participa&#231;&#227;o como n&#227;o influ&#234;ncia&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> Uma situa&#231;&#227;o semelhante foi observada no desenvolvimento da psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Nesse sentido&#44; considerando a poss&#237;vel contribui&#231;&#227;o da fun&#231;&#227;o autoimune na alopecia&#44; estudos de variantes gen&#233;ticas do gene CTLA4 foram conduzidos em diversas popula&#231;&#245;es&#46; Uma an&#225;lise anterior dessa associa&#231;&#227;o sugeriu o poss&#237;vel envolvimento das variantes do gene CTLA4 como fator de risco no desenvolvimento de AA em uma popula&#231;&#227;o europeia&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> com efeito mais forte em pacientes com formas acentuadas da doen&#231;a&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Outro estudo feito em uma popula&#231;&#227;o italiana&#44; no qual foram analisadas as variantes dos genes rs231775 e rs3087243&#44; apontou esse &#250;ltimo como fator de risco no desenvolvimento de AA em placas&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> Por outro lado&#44; estudo feito no Ir&#227; n&#227;o conseguiu provar a associa&#231;&#227;o da variante do gene rs3087243 no desenvolvimento de AA&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Em estudo anterior&#44; os autores observaram a participa&#231;&#227;o de variantes gen&#233;ticas de TNF&#945; e PTPN22<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> como fator de risco para AA em pacientes mexicanos&#59; a fun&#231;&#227;o de ambos os genes est&#225; relacionada &#224; regula&#231;&#227;o dos mecanismos imunol&#243;gicos&#46; No entanto&#44; a participa&#231;&#227;o das variantes gen&#233;ticas do CTLA4 na AA n&#227;o foi analisada nessa popula&#231;&#227;o&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Alguns SNPs dentro do gene CTLA&#8208;4 j&#225; foram analisados quanto &#224; suscetibilidade &#224; artrite reumatoide &#40;AR&#41; na popula&#231;&#227;o mexicana&#59; entre eles&#44; rs5742909&#44; rs231775 e rs3087243&#59; sugere&#8208;se que o hapl&#243;tipo &#8208;319C&#47;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49G&#47;CT60G do gene CTLA&#8208;4 &#233; fator de risco para AR&#44; enquanto que o SNP rs3087243 pode ser fator protetor contra esse tipo de doen&#231;a autoimune&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">No entanto&#44; n&#227;o foram observadas diferen&#231;as significativas para rs231775 e rs3087243 no presente estudo &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#44; sugeriu&#8208;se que essas variantes n&#227;o s&#227;o fator de risco no desenvolvimento de AA ou de AA em placas na popula&#231;&#227;o mexicana&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclus&#227;o</span><p id="par0095" class="elsevierStylePara elsevierViewall">As variantes gen&#233;ticas rs231775 e rs3087243 do gene CTLA4 n&#227;o constituem fator de risco no desenvolvimento de AA na popula&#231;&#227;o mexicana de Monterrey&#44; M&#233;xico&#46; Al&#233;m disso&#44; essas variantes gen&#233;ticas n&#227;o apresentam associa&#231;&#227;o com antecedentes familiares&#47;pessoais de doen&#231;as autoimunes ou com o g&#234;nero dos sujeitos do estudo&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Suporte financeiro</span><p id="par0100" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Contribui&#231;&#227;o dos autores</span><p id="par0105" class="elsevierStylePara elsevierViewall">Mauricio Andr&#233;s Salinas Santander&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Cristina Susana Cantu&#8208;Salinas&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Jorge Ocampo&#8208;Candiani&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Victor de Jesus Suarez&#8208;Valencia&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Jennifer Guadalupe Ramirez&#8208;Guerrero&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Celia Nohemi Sanchez&#8208;Dominguez&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflitos de interesse</span><p id="par0135" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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            0 => "Alopecia areata"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar9030" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata &#233; doen&#231;a autoimune que causa perda de cabelo sem cicatrizes na les&#227;o&#46; As variantes gen&#233;ticas do gene do ant&#237;geno 4 associado ao linf&#243;cito T citot&#243;xico &#40;CTLA4&#41;&#44; um regulador negativo da resposta das c&#233;lulas T&#44; foram associadas a predisposi&#231;&#227;o a doen&#231;as autoimunes em diferentes popula&#231;&#245;es&#59; no entanto&#44; o envolvimento dessas variantes gen&#233;ticas no desenvolvimento da alopecia areata &#233; controverso&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Avaliar a associa&#231;&#227;o potencial de duas variantes do gene CTLA4 e alopecia areata em uma popula&#231;&#227;o mexicana&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Foram genotipadas por PCR&#8208;RFLP as variantes<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; de 50 pacientes com alopecia areata e 100 controles saud&#225;veis&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">N&#227;o foi observada diferen&#231;a estat&#237;stica para alguma das variantes gen&#233;ticas quanto &#224;s frequ&#234;ncias al&#233;licas ou genot&#237;picas entre os pacientes com alopecia areata e controles quando considerados os par&#226;metros de hist&#243;ria familiar&#47;pessoal de doen&#231;as autoimunes ou sexo &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Amostra pequena de pacientes e coleta de dados em apenas uma popula&#231;&#227;o do nordeste do M&#233;xico&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">As variantes gen&#233;ticas rs231775 e rs3087243 do gene CTLA4 n&#227;o s&#227;o um fator de risco para o desenvolvimento de alopecia areata na popula&#231;&#227;o mexicana analisada&#46;</p></span>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Salinas&#8208;Santander MA&#44; Cantu&#8208;Salinas CS&#44; Ocampo&#8208;Candiani J&#44; Suarez&#8208;Valencia VJ&#44; Ramirez&#8208;Guerrero JG&#44; Sanchez&#8208;Dominguez CN&#46; CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; and CT60 &#40;rs3087243&#41; gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico&#46; An Bras Dermatol&#46; 2020&#59;95&#58;283&#8211;8&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Trabalho realizado no Departamento de Investiga&#231;&#227;o&#44; Faculdade de Medicina da Universidade de Saltillo&#44; Universidade Aut&#244;noma de Coahuila&#44; Saltillo&#44; Coahuila&#44; M&#233;xico e Servi&#231;o de Dermatologia&#44; Hospital Universit&#225;rio Dr&#46; Jos&#233; Eleuterio Gonz&#225;lez&#44; Faculdade de Medicina&#44; Universidade Aut&#244;noma de Nuevo Le&#243;n&#44; Nuevo Le&#243;n&#44; M&#233;xico&#46;</p>"
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                  """
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          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise das variantes gen&#233;ticas CTLA4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG &#40;rs231775&#41; e CT60 &#40;rs3087243&#41; por sexo e hist&#243;ria pessoal&#47;familiar de doen&#231;as autoimunes</p>"
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                      "titulo" => "Polymorphism of FAS and FAS Ligand Genes in Alopecia Areata&#58; A Case&#8208;control Study in Egyptian Population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "O&#46;A&#46; Bakry"
                            2 => "E&#46;A&#46;E&#46; Gayed"
                            3 => "A&#46;E&#46;D&#46; Gawad"
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                        "tituloSerie" => "Indian J Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "63"
                        "paginaInicial" => "220"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29937558"
                            "web" => "Medline"
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                      "titulo" => "Deletion of CTLA&#8208;4 on regulatory T cells during adulthood leads to resistance to autoimmunity"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "S&#46;B&#46; Lovitch"
                            2 => "P&#46;T&#46; Sage"
                            3 => "V&#46;R&#46; Juneja"
                            4 => "Y&#46; Lee"
                            5 => "J&#46;D&#46; Trombley"
                          ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20141030"
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                        "tituloSerie" => "J Exp Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "212"
                        "paginaInicial" => "1603"
                        "paginaFinal" => "1621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26371185"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Genetic variants in CTLA4 are strongly associated with alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;K&#46; John"
                            1 => "F&#46;F&#46; Brockschmidt"
                            2 => "S&#46; Redler"
                            3 => "C&#46; Herold"
                            4 => "S&#46; Hanneken"
                            5 => "S&#46; Eigelshoven"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2010.427"
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                        "tituloSerie" => "J Invest Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "131"
                        "paginaInicial" => "1169"
                        "paginaFinal" => "1172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21346773"
                            "web" => "Medline"
                          ]
                        ]
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              "etiqueta" => "9"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Cytotoxic T&#8208;lymphocyte antigen 4 &#40;CTLA4&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49AG and CT60 gene polymorphisms in Alopecia Areata&#58; a case&#8208;control association study in the Italian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Megiorni"
                            1 => "B&#46; Mora"
                            2 => "C&#46; Maxia"
                            3 => "M&#46; Gerardi"
                            4 => "A&#46; Pizzuti"
                            5 => "A&#46; Rossi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00403-013-1348-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res&#46;"
                        "fecha" => "2013"
                        "volumen" => "305"
                        "paginaInicial" => "665"
                        "paginaFinal" => "670"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23567921"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in northern Chinese population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Sun"
                            1 => "Y&#46; Meng"
                            2 => "Y&#46; Xie"
                            3 => "H&#46; Zhang"
                            4 => "Z&#46; Zhang"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0101986"
                      "Revista" => array:5 [
                        "tituloSerie" => "PloS One&#46;"
                        "fecha" => "2014"
                        "volumen" => "9"
                        "paginaInicial" => "e101986"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25003519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0155"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and burden of alopecia areata&#58; a systematic review"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;C&#46; Villasante Fricke"
                            1 => "M&#46; Miteva"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/CCID.S53985"
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                        "tituloSerie" => "Clin Cosmet Investig Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "8"
                        "paginaInicial" => "397"
                        "paginaFinal" => "403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26244028"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genome&#8208;wide meta&#8208;analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Betz"
                            1 => "L&#46; Petukhova"
                            2 => "S&#46; Ripke"
                            3 => "H&#46; Huang"
                            4 => "A&#46; Menelaou"
                            5 => "S&#46; Redler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Nat Commun&#46;"
                        "fecha" => "2015"
                        "volumen" => "6"
                        "paginaInicial" => "5966"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0165"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA&#8208;4&#58; a moving target in immunotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Rowshanravan"
                            1 => "N&#46; Halliday"
                            2 => "D&#46;M&#46; Sansom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2017-06-741033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood&#46;"
                        "fecha" => "2018"
                        "volumen" => "131"
                        "paginaInicial" => "58"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29118008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CTLA&#8208;4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49 G&#47;A Polymorphism Confers Autoimmune Disease Risk&#58; An Updated Meta&#8208;Analysis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Wang"
                            1 => "Q&#46; Zhu"
                            2 => "Y&#46; Lu"
                            3 => "H&#46; Lu"
                            4 => "F&#46; Zhang"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/gtmb.2016.0335"
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                        "tituloSerie" => "Genet Test Mol Biomarkers&#46;"
                        "fecha" => "2017"
                        "volumen" => "21"
                        "paginaInicial" => "222"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28384040"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0175"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of Cytotoxic T&#8208;Lymphocyte&#8208;Associated Protein 4 &#40;CTLA4&#41; Gene Polymorphisms with Autoimmune Thyroid Disease in Children and Adults&#58; Case&#8208;Control Study"
                      "autores" => array:1 [
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                            1 => "M&#46;N&#46; Chien"
                            2 => "F&#46;S&#46; Lo"
                            3 => "C&#46;H&#46; Wang"
                            4 => "C&#46;Y&#46; Huang"
                            5 => "C&#46;L&#46; Lin"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "PloS one&#46;"
                        "fecha" => "2016"
                        "volumen" => "11"
                        "paginaInicial" => "e0154394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27111218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0180"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "CTLA&#8208;4 A49G gene polymorphism is not associated with vitiligo in South Indian population"
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                          "etal" => false
                          "autores" => array:6 [
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                            1 => "R&#46; Syed"
                            2 => "J&#46; Quareen"
                            3 => "M&#46;A&#46; Waheed"
                            4 => "K&#46; Jamil"
                            5 => "H&#46; Rao"
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                        ]
                      ]
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                  ]
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                    0 => array:2 [
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                        "tituloSerie" => "Indian J Dermatol&#46;"
                        "fecha" => "2010"
                        "volumen" => "55"
                        "paginaInicial" => "29"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20418973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0185"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between cytotoxic T&#8208;lymphocyte antigen&#8208;4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49A&#47;G polymorphism and psoriasis and vitiligo&#58; A meta&#8208;analysis of case&#8208;control studies"
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                          "autores" => array:6 [
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                            2 => "Q&#46; Luo"
                            3 => "W&#46; Li"
                            4 => "X&#46; Tian"
                            5 => "F&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "volumen" => "568"
                        "paginaInicial" => "196"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26013045"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of Cytotoxic T Lymphocyte Antigen&#8208;4 Gene Polymorphisms with Psoriasis Vulgaris&#58; A Case&#8208;Control Study in Turkish Population"
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                      ]
                    ]
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                        "tituloSerie" => "J Immunol Res&#46;"
                        "fecha" => "2018"
                        "volumen" => "2018"
                        "paginaInicial" => "1643906"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29850619"
                            "web" => "Medline"
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                        ]
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                    ]
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                ]
              ]
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              "identificador" => "bib0195"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Association between PTPN22 C1858T polymorphism and alopecia areata risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Salinas-Santander"
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                            3 => "H&#46; Gonzalez-Cardenas"
                            4 => "A&#46;C&#46; Cepeda-Nieto"
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                        "tituloSerie" => "Exp Ther Med&#46;"
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                        "volumen" => "10"
                        "paginaInicial" => "1953"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26640579"
                            "web" => "Medline"
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                    ]
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                ]
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                    0 => array:2 [
                      "titulo" => "The &#8208;319C&#47;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>49G&#47;CT60G haplotype of CTLA&#8208;4 gene confers susceptibility to rheumatoid arthritis in Mexican population"
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                            2 => "N&#46;M&#46; Torres-Carrillo"
                            3 => "I&#46; Parra-Rojas"
                            4 => "H&#46; Rangel-Villalobos"
                            5 => "M&#46;G&#46; Ramirez-Duenas"
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                        "tituloSerie" => "Cell Biochem Biophys&#46;"
                        "fecha" => "2013"
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                        "paginaInicial" => "1217"
                        "paginaFinal" => "1228"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23703660"
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2020 Setembro 23 10 33
2020 Agosto 12 12 24
2020 Julho 19 16 35
2020 Junho 18 19 37
2020 Maio 7 9 16
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