array:24 [
  "pii" => "S0365059620301197"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2019.11.008"
  "estado" => "S300"
  "fechaPublicacion" => "2020-07-01"
  "aid" => "191"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2020"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "crp"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275220301892"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2020.05.003"
      "estado" => "S300"
      "fechaPublicacion" => "2020-07-01"
      "aid" => "191"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "crp"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso Cl&#237;nico</span>"
        "titulo" => "Linfangioma at&#237;pico e hiperceratose em paciente com obesidade m&#243;rbida"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "tieneResumen" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "477"
            "paginaFinal" => "479"
          ]
        ]
        "contieneResumen" => array:1 [
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 804
                "Ancho" => 1008
                "Tamanyo" => 149158
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Prolifera&#231;&#227;o de vasos linf&#225;ticos dilatados com paredes finas e irregulares&#44; revestidas por c&#233;lulas endoteliais tumefeitas na derme e com agregados linfocit&#225;rios t&#237;picos&#59; histopatologia &#40;Hematoxilina &#38; eosina&#44; 10&#215;&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Cristian Mor&#225;n&#8208;Mari&#241;os, Wendy Nieto&#8208;Gutierrez, Josmel Pacheco&#8208;Mendoza"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Cristian"
                "apellidos" => "Mor&#225;n&#8208;Mari&#241;os"
              ]
              1 => array:2 [
                "nombre" => "Wendy"
                "apellidos" => "Nieto&#8208;Gutierrez"
              ]
              2 => array:2 [
                "nombre" => "Josmel"
                "apellidos" => "Pacheco&#8208;Mendoza"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059620301197"
          "doi" => "10.1016/j.abd.2019.11.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301197?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220301892?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009500000004/v2_202008070652/S2666275220301892/v2_202008070652/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059620301227"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2019.10.005"
    "estado" => "S300"
    "fechaPublicacion" => "2020-07-01"
    "aid" => "194"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "crp"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Multinucleate cell angiohistiocytoma&#58; an uncommon cutaneous tumor"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "480"
          "paginaFinal" => "483"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 563
              "Ancho" => 755
              "Tamanyo" => 76616
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Characteristic irregular multinucleate cells of MCAH&#44; typified by angular borders and multiple potentially hyperchromatic nuclei in the dermis and enlargement of endothelial nuclei in the capillaries &#40;Hematoxylin &#38; eosin&#44; &#215;400&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Anderson Alves Costa, Glaucia Ferreira Wedy, Walter Belda Junior, Paulo Ricardo Criado"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Anderson Alves"
              "apellidos" => "Costa"
            ]
            1 => array:2 [
              "nombre" => "Glaucia Ferreira"
              "apellidos" => "Wedy"
            ]
            2 => array:2 [
              "nombre" => "Walter Belda"
              "apellidos" => "Junior"
            ]
            3 => array:2 [
              "nombre" => "Paulo Ricardo"
              "apellidos" => "Criado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220301922"
        "doi" => "10.1016/j.abdp.2020.05.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220301922?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301227?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301227/v3_202008041755/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S036505962030115X"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2019.08.032"
    "estado" => "S300"
    "fechaPublicacion" => "2020-07-01"
    "aid" => "188"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "crp"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Partial repigmentation of vitiligo with tofacitinib&#44; without exposure to ultraviolet radiation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "473"
          "paginaFinal" => "476"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Figure 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 761
              "Ancho" => 1674
              "Tamanyo" => 126534
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Prior to treatment&#44; numerous white macules&#46; &#40;B&#41; After two years of treatment&#44; repigmentation is nearly complete&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Melpone Komnitski, Angelo Komnitski, Amilton Komnitski Junior, Caio C&#233;sar Silva de Castro"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Melpone"
              "apellidos" => "Komnitski"
            ]
            1 => array:2 [
              "nombre" => "Angelo"
              "apellidos" => "Komnitski"
            ]
            2 => array:2 [
              "nombre" => "Amilton"
              "apellidos" => "Komnitski Junior"
            ]
            3 => array:2 [
              "nombre" => "Caio C&#233;sar"
              "apellidos" => "Silva de Castro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220301867"
        "doi" => "10.1016/j.abdp.2019.08.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220301867?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962030115X?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000004/v3_202008041755/S036505962030115X/v3_202008041755/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
    "titulo" => "Atypical lymphangioma and hyperkeratosis in a patient with morbid obesity"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "477"
        "paginaFinal" => "479"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Cristian Mor&#225;n-Mari&#241;os, Wendy Nieto-Gutierrez, Josmel Pacheco-Mendoza"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Cristian"
            "apellidos" => "Mor&#225;n-Mari&#241;os"
            "email" => array:1 [
              0 => "cp.moran94@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Wendy"
            "apellidos" => "Nieto-Gutierrez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Josmel"
            "apellidos" => "Pacheco-Mendoza"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Bibliometric Investigation Unit&#44; Universidad San Ignacio de Loyola&#44; Lima&#44; Peru"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institute for the Evaluation of Health Technologies and Investigation&#44; Seguro Social de Salud del Per&#250;&#44; Lima&#44; Peru"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 702
            "Ancho" => 1007
            "Tamanyo" => 148207
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multiple&#44; grouped lesions of irregular size with purulent discharge&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Circumscribed lymphangioma &#40;LC&#41; is infrequent and usually develops congenitally&#44; being detected up to 90&#37; of the cases in the first decade of life&#59; however&#44; it can also develop in adulthood&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">LC in the adult generally appears in areas affected by trauma&#44; infection&#44; or radiation&#44; but it is also reported to appear spontaneously&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> It is described clinically as lumpy papules&#44; and as verrucose or firm vesicles with a smooth surface&#44; and is classified as a plaque&#44; characterized by its lymphatic content&#46; Histopathological examination describes dilated lymphatic vessels in the papillary dermis that elevate the epidermis above the surrounding skin&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Reports of large-volume lymphangioma are very seldom described in the literature&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 51-year-old male from Peru&#44; with a history of liver failure and morbid obesity&#44; was transferred to the emergency department with a time of illness of eight months due to the presence of small tumor lesions at the pubic level&#44; which evolved to become large&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Upon physical examination&#44; multiple lesions with a cystic appearance&#44; conglomerated&#44; with raised and umbilicated borders were evidenced in the pubis&#59; with a diameter of up to13<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>cm in which&#44; through their orifices&#44; they presented a purulent and foul exudate&#46; The lesions extended to the scrotal region where they were associated with grouped vesicles that bled during mobilization &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The lower limbs showed scaly and cracked plaques with hard-consistency hyperkeratosis due to chronic lymphangitis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Histopathological studies of the biopsy concluded with the diagnosis of circumscribed lymphangioma &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The patient was treated with daily cures and antibiotics such as oxacillin and clindamycin during his hospital stay&#46; After two weeks of treatment&#44; the patient progressed with favorable evolution of the lesions&#44; with a decrease in size at the level of the pubis and scrotal region&#59; however&#44; due to the patient&#39;s underlying liver disease&#44; he died a month before he could undergo surgery&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Lymphangioma is an infrequent and benign malformation of the lymphatic system&#44; which can be classified according to the size or depth of the lesion&#46; Although the authors report this entity as having a large volume&#44; it lacks malignant potential&#44; explaining the increase in size due to its ability to branch out and grow in a disorderly manner&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The location of this entity is more frequent in the extremities&#44; neck&#44; and trunk&#44; while the appearance in the scrotal region is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> The lesions described in the patient are not those that are usually mentioned in the literature&#59; the time of illness and the presence of associated infection&#44; and morbid obesity&#44; which probably contributed to the magnitude of the volume and expansion&#44; must be considered&#46; Moreover&#44; a significant reduction of the size and secretion of the lesions was observed due to the use of antibiotics and daily cures&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The examiner should consider the characteristics of the lesions&#44; which may be confused with condyloma acuminatum&#44; molluscum&#44; contagiosum&#44; or herpes&#46; A thorough inspection and an adequate clinical history can exclude these differential diagnoses&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In lymphangiomas&#44; the basic treatment without risk of infection involves the use of surgical resection&#44; CO<span class="elsevierStyleInf">2</span> laser&#44; or sclerotherapy&#59; however there is the possibility of a spontaneous regression after three months that happens only in the macrocystic lymphangioma&#44; while in the rest&#44; the risk of recurrence appears between six months to six years&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The biopsy sample was considered to be a limitation because it was not representative&#44; since some histopathological characteristics were not similar to those reported by other studies&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> When the sampling was to be repeated in the scrotal region&#44; the patient had died&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In summary&#44; lymphangioma is an infrequent pathology in adults and the authors infer that the time of evolution&#44; infection&#44; and morbid obesity of the patient could have contributed to the atypical clinical manifestations described&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors&#8217; contributions</span><p id="par0075" class="elsevierStylePara elsevierViewall">Cristian Mor&#225;n-Mari&#241;os&#58; Statistical analysis&#59; approval of final version of the manuscript&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Wendy Nieto-Gutierrez&#58; Approval of final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Josmel Pacheco-Mendoza&#58; Approval of final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:3 [
          "identificador" => "xres1370006"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1259078"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        3 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case report"
        ]
        4 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        5 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Financial support"
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Authors&#8217; contributions"
        ]
        7 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conflicts of interest"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-06-25"
    "fechaAceptado" => "2019-11-27"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1259078"
          "palabras" => array:3 [
            0 => "Ichthyosis"
            1 => "Lymphangioma"
            2 => "Obesity&#44; morbid"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lymphangioma is a rare and understudied pathology that is usually detected in the first decade of life&#44; and its appearance in adults is rare&#46; This report details a 51-year-old man with morbid obesity who presented&#44; for the last eight months&#44; multiple asymmetric tumor lesions with extension to the scrotal region&#46; The diagnosis of circumscribed lymphangioma with associated infection was confirmed&#46; This case report demonstrates an unusual presentation of the characteristics of the lymphangioma that are seldom described in the literature&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Mor&#225;n-Mari&#241;os C&#44; Nieto-Gutierrez W&#44; Pacheco-Mendoza J&#46; Atypical lymphangioma and hyperkeratosis in a patient with morbid obesity&#46; An Bras Dermatol&#46; 2020&#59;95&#58;477&#8211;9&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Universidad San Ignacio de Loyola&#44; Lima&#44; Peru&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 702
            "Ancho" => 1007
            "Tamanyo" => 148207
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multiple&#44; grouped lesions of irregular size with purulent discharge&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 804
            "Ancho" => 1007
            "Tamanyo" => 162794
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Proliferation of dilated lymphatic vessels with thin&#44; irregular walls&#44; lined by soft endothelial cells in the papillary dermis and with non-atypical lymphocytic aggregates&#59; histopathology &#40;Hematoxylin &#38; eosin&#44; x10&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular anomalies classification&#58; recommendations from the International Society for the Study of Vascular Anomalies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Wassef"
                            1 => "F&#46; Blei"
                            2 => "D&#46; Adams"
                            3 => "A&#46; Alomari"
                            4 => "E&#46; Baselga"
                            5 => "A&#46; Berenstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2014-3673"
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2015"
                        "volumen" => "136"
                        "paginaInicial" => "e203"
                        "paginaFinal" => "e214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26055853"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673619307652"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of lymphangioma circumscriptum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46;W&#46; Whimster"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.1976.tb05134.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1976"
                        "volumen" => "94"
                        "paginaInicial" => "473"
                        "paginaFinal" => "486"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1268059"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lymphangioma of the palatine tonsil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Mardekian"
                            1 => "J&#46;K&#46; Karp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5858/arpa.2012-0678-RS"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Pathol Lab Med"
                        "fecha" => "2013"
                        "volumen" => "137"
                        "paginaInicial" => "1837"
                        "paginaFinal" => "1842"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24283866"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lymphangioma circumscriptum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46;M&#46; Kohn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s15006-016-9104-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "MMW Fortschritte der Medizin"
                        "fecha" => "2016"
                        "volumen" => "158"
                        "paginaInicial" => "59"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27966128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopy of lymphangioma circumscriptum&#58; a morphological study of 45 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Zaballos"
                            1 => "L&#46;J&#46; Del Pozo"
                            2 => "G&#46; Argenziano"
                            3 => "I&#46;K&#46; Karaarslan"
                            4 => "C&#46; Landi"
                            5 => "A&#46; Vera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ajd.12668"
                      "Revista" => array:6 [
                        "tituloSerie" => "Australas J Dermatol"
                        "fecha" => "2018"
                        "volumen" => "59"
                        "paginaInicial" => "e189"
                        "paginaFinal" => "e193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28752523"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spontaneous regression of lymphangiomas in a single center over 34 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Kato"
                            1 => "S&#46; Watanabe"
                            2 => "R&#46; Kato"
                            3 => "H&#46; Kawashima"
                            4 => "T&#46; Iida"
                            5 => "A&#46; Watanabe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/GOX.0000000000001501"
                      "Revista" => array:5 [
                        "tituloSerie" => "Plast Reconstr Surg Glob Open"
                        "fecha" => "2017"
                        "volumen" => "5"
                        "paginaInicial" => "e1501"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29062665"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301197/v3_202008041755/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "80638"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Report"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000004/v3_202008041755/S0365059620301197/v3_202008041755/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301197?idApp=UINPBA00008Z"
]
Compartilhar
Informação da revista
Vol. 95. Núm. 4.
Páginas 477-479 (1 julho 2020)
Compartilhar
Compartilhar
Baixar PDF
Mais opções do artigo
Visitas
6491
Vol. 95. Núm. 4.
Páginas 477-479 (1 julho 2020)
Case Report
Open Access
Atypical lymphangioma and hyperkeratosis in a patient with morbid obesity
Visitas
6491
Cristian Morán-Mariñosa,
Autor para correspondência
cp.moran94@gmail.com

Corresponding author.
, Wendy Nieto-Gutierrezb, Josmel Pacheco-Mendozaa
a Bibliometric Investigation Unit, Universidad San Ignacio de Loyola, Lima, Peru
b Institute for the Evaluation of Health Technologies and Investigation, Seguro Social de Salud del Perú, Lima, Peru
Este item recebeu

Under a Creative Commons license
Informação do artigo
Resume
Texto Completo
Bibliografia
Baixar PDF
Estatísticas
Figuras (2)
Abstract

Lymphangioma is a rare and understudied pathology that is usually detected in the first decade of life, and its appearance in adults is rare. This report details a 51-year-old man with morbid obesity who presented, for the last eight months, multiple asymmetric tumor lesions with extension to the scrotal region. The diagnosis of circumscribed lymphangioma with associated infection was confirmed. This case report demonstrates an unusual presentation of the characteristics of the lymphangioma that are seldom described in the literature.

Keywords:
Ichthyosis
Lymphangioma
Obesity, morbid
Texto Completo
Introduction

Circumscribed lymphangioma (LC) is infrequent and usually develops congenitally, being detected up to 90% of the cases in the first decade of life; however, it can also develop in adulthood.1

LC in the adult generally appears in areas affected by trauma, infection, or radiation, but it is also reported to appear spontaneously.2 It is described clinically as lumpy papules, and as verrucose or firm vesicles with a smooth surface, and is classified as a plaque, characterized by its lymphatic content. Histopathological examination describes dilated lymphatic vessels in the papillary dermis that elevate the epidermis above the surrounding skin.2

Reports of large-volume lymphangioma are very seldom described in the literature.

Case report

A 51-year-old male from Peru, with a history of liver failure and morbid obesity, was transferred to the emergency department with a time of illness of eight months due to the presence of small tumor lesions at the pubic level, which evolved to become large.

Upon physical examination, multiple lesions with a cystic appearance, conglomerated, with raised and umbilicated borders were evidenced in the pubis; with a diameter of up to13cm×7cm in which, through their orifices, they presented a purulent and foul exudate. The lesions extended to the scrotal region where they were associated with grouped vesicles that bled during mobilization (Fig. 1).

Figure 1.

Multiple, grouped lesions of irregular size with purulent discharge.

(0.14MB).

The lower limbs showed scaly and cracked plaques with hard-consistency hyperkeratosis due to chronic lymphangitis.

Histopathological studies of the biopsy concluded with the diagnosis of circumscribed lymphangioma (Fig. 2). The patient was treated with daily cures and antibiotics such as oxacillin and clindamycin during his hospital stay. After two weeks of treatment, the patient progressed with favorable evolution of the lesions, with a decrease in size at the level of the pubis and scrotal region; however, due to the patient's underlying liver disease, he died a month before he could undergo surgery.

Figure 2.

Proliferation of dilated lymphatic vessels with thin, irregular walls, lined by soft endothelial cells in the papillary dermis and with non-atypical lymphocytic aggregates; histopathology (Hematoxylin & eosin, x10).

(0.16MB).
Discussion

Lymphangioma is an infrequent and benign malformation of the lymphatic system, which can be classified according to the size or depth of the lesion. Although the authors report this entity as having a large volume, it lacks malignant potential, explaining the increase in size due to its ability to branch out and grow in a disorderly manner.3

The location of this entity is more frequent in the extremities, neck, and trunk, while the appearance in the scrotal region is rare.4 The lesions described in the patient are not those that are usually mentioned in the literature; the time of illness and the presence of associated infection, and morbid obesity, which probably contributed to the magnitude of the volume and expansion, must be considered. Moreover, a significant reduction of the size and secretion of the lesions was observed due to the use of antibiotics and daily cures.

The examiner should consider the characteristics of the lesions, which may be confused with condyloma acuminatum, molluscum, contagiosum, or herpes. A thorough inspection and an adequate clinical history can exclude these differential diagnoses.5

In lymphangiomas, the basic treatment without risk of infection involves the use of surgical resection, CO2 laser, or sclerotherapy; however there is the possibility of a spontaneous regression after three months that happens only in the macrocystic lymphangioma, while in the rest, the risk of recurrence appears between six months to six years.6

The biopsy sample was considered to be a limitation because it was not representative, since some histopathological characteristics were not similar to those reported by other studies.5 When the sampling was to be repeated in the scrotal region, the patient had died.

In summary, lymphangioma is an infrequent pathology in adults and the authors infer that the time of evolution, infection, and morbid obesity of the patient could have contributed to the atypical clinical manifestations described.

Financial support

None declared.

Authors’ contributions

Cristian Morán-Mariños: Statistical analysis; approval of final version of the manuscript; drafting and editing of the manuscript; collection, analysis, and interpretation of data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.

Wendy Nieto-Gutierrez: Approval of final version of the manuscript; drafting and editing of the manuscript; critical review of the literature; critical review of the manuscript.

Josmel Pacheco-Mendoza: Approval of final version of the manuscript; drafting and editing of the manuscript; critical review of the literature; critical review of the manuscript.

Conflicts of interest

None declared.

References
[1]
M. Wassef, F. Blei, D. Adams, A. Alomari, E. Baselga, A. Berenstein, et al.
Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies.
Pediatrics, 136 (2015), pp. e203-e214
[2]
I.W. Whimster.
The pathology of lymphangioma circumscriptum.
Br J Dermatol, 94 (1976), pp. 473-486
[3]
S. Mardekian, J.K. Karp.
Lymphangioma of the palatine tonsil.
Arch Pathol Lab Med, 137 (2013), pp. 1837-1842
[4]
F.M. Kohn.
Lymphangioma circumscriptum.
MMW Fortschritte der Medizin, 158 (2016), pp. 59-60
[5]
P. Zaballos, L.J. Del Pozo, G. Argenziano, I.K. Karaarslan, C. Landi, A. Vera, et al.
Dermoscopy of lymphangioma circumscriptum: a morphological study of 45 cases.
Australas J Dermatol, 59 (2018), pp. e189-e193
[6]
M. Kato, S. Watanabe, R. Kato, H. Kawashima, T. Iida, A. Watanabe.
Spontaneous regression of lymphangiomas in a single center over 34 years.
Plast Reconstr Surg Glob Open, 5 (2017), pp. e1501

How to cite this article: Morán-Mariños C, Nieto-Gutierrez W, Pacheco-Mendoza J. Atypical lymphangioma and hyperkeratosis in a patient with morbid obesity. An Bras Dermatol. 2020;95:477–9.

Study conducted at the Universidad San Ignacio de Loyola, Lima, Peru.

Copyright © 2020. Sociedade Brasileira de Dermatologia
Baixar PDF
Idiomas
Anais Brasileiros de Dermatologia (Portuguese)
Opções de artigo
Ferramentas
en pt
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.