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Th17 e Th&#8208;22&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">2</span></a> Essas c&#233;lulas ativadas produzem muitas citocinas&#44; incluindo fator de necrose tumoral &#40;TNF&#41;&#8208;&#945;&#44; interleucina &#40;IL&#41;&#8208;1&#44; IL&#8208;17&#44; fator de crescimento endotelial vascular &#40;VEGF&#44; <span class="elsevierStyleItalic">vascular endothelial growth factor</span>&#41;&#44; IL&#8208;6&#44; IL&#8208;22&#44; IL&#8208;23 e interferon&#8208;&#947; &#40;IFN&#8208;&#947;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">2&#8211;4</span></a> Al&#233;m disso&#44; esses mediadores podem levar a inflama&#231;&#227;o sist&#234;mica que desencadeia disfun&#231;&#227;o do endot&#233;lio endovascular&#44; aumento do estresse oxidativo&#44; hipercoagula&#231;&#227;o e aumento da angiog&#234;nese&#44; que tamb&#233;m s&#227;o os principais componentes das les&#245;es cardiovasculares e aterosclerose&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">1&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">SCUBE&#8208;1 &#40;<span class="elsevierStyleItalic">Signal peptide&#8208;CUB&#8208;EGF domain&#8208;containing protein 1</span>&#41; &#233; membro de uma fam&#237;lia de prote&#237;nas localizada na superf&#237;cie celular &#8211; as prote&#237;nas SCUBE &#8211; que podem ser detectadas em processos inflamat&#243;rios e angiog&#234;nese&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#8211;8</span></a> Em estudos recentes&#44; a prote&#237;na SCUBE&#8208;1 foi detectada em c&#233;lulas endoteliais vasculares e plaquetas conhecidas por desempenharem pap&#233;is cruciais no processo de trombose arterial&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">9&#44;10</span></a> Al&#233;m disso&#44; h&#225; um estudo avaliando os n&#237;veis s&#233;ricos de VEGF&#44; SCUBE&#8208;1 e SCUBE&#8208;3 em pacientes com psor&#237;ase&#44; no qual os autores afirmam que SCUBE&#8208;1 pode estar relacionada &#224; patog&#234;nese da psor&#237;ase&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">11</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A espessura &#237;ntima&#8208;m&#233;dia carot&#237;dea &#40;EIMC&#41; &#233; a medida da espessura da parede da art&#233;ria car&#243;tida avaliada na ultrassonografia&#44; e mesmo altera&#231;&#245;es iniciais da aterosclerose podem ser diagnosticadas diretamente por esse m&#233;todo&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">12</span></a> Alguns estudos relataram que pacientes com psor&#237;ase t&#234;m valores de EIMC mais altos do que controles saud&#225;veis n&#227;o psori&#225;sicos&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">13&#8211;15</span></a>Al&#233;m disso&#44; eles alegaram que a psor&#237;ase &#233; fator de risco independente para aumento da EIMC&#44; que indica aterosclerose subcl&#237;nica&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">13</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">O presente estudo teve como objetivo avaliar aterosclerose subcl&#237;nica em pacientes com psor&#237;ase pela medida da EIMC&#44; n&#237;veis de SCUBE&#8208;1 e par&#226;metros metab&#243;licos&#44; al&#233;m de compar&#225;&#8208;los entre pacientes psori&#225;sicos e controles saud&#225;veis n&#227;o psori&#225;sicos e&#44; assim&#44; investigar se SCUBE&#8208;1 poderia desempenhar papel tanto na patog&#234;nese da psor&#237;ase quanto da aterosclerose&#46; Que seja de conhecimento dos autores&#44; este &#233; o primeiro estudo na literatura avaliando os n&#237;veis de SCUBE&#8208;1 e a medida da EIMC simultaneamente em pacientes psori&#225;sicos e controles saud&#225;veis&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material e m&#233;todo</span><p id="par0030" class="elsevierStylePara elsevierViewall">Este estudo prospectivo de caso&#8208;controle foi revisado pelo Comit&#234; de &#201;tica do Suleyman Demirel University Hospital e aprovado pela decis&#227;o n&#250;mero 370 em 23&#47;12&#47;2019&#46; Este protocolo de estudo foi consistente com a Declara&#231;&#227;o de Helsinque&#44; e consentimento informado foi obtido de cada um dos participantes&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Popula&#231;&#227;o do estudo</span><p id="par0035" class="elsevierStylePara elsevierViewall">Pacientes diagnosticados com psor&#237;ase na histopatologia e&#47;ou clinicamente&#44; com idade entre 18 e 65 anos&#44; atendidos no Ambulat&#243;rio de Dermatologia do Suleyman Demirel University Hospital entre janeiro de 2020 a janeiro de 2021&#44; foram considerados para este estudo&#46; Pacientes com hist&#243;rico de qualquer evento cardiovascular ou cerebrovascular&#44; infec&#231;&#227;o ativa e doen&#231;as inflamat&#243;rias sist&#234;micas ou cut&#226;neas&#44; exceto psor&#237;ase&#44; e ingest&#227;o regular de medicamentos por qualquer motivo foram exclu&#237;dos&#46; Obteve&#8208;se hist&#243;rico detalhado dos pacientes&#44; foi realizado exame dermatol&#243;gico e a presen&#231;a de artrite e&#47;ou envolvimento das unhas tamb&#233;m foi avaliada e anotada&#46; Os &#237;ndices de &#193;rea e Gravidade da Psor&#237;ase &#40;PASI&#44; do ingl&#234;s <span class="elsevierStyleItalic">Psoriasis Area and Severity Index</span>&#41;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">16</span></a> foram calculados e&#44; de acordo com os mesmos&#44; os pacientes foram subdivididos em dois grupos&#58; doen&#231;a leve&#44; com escore PASI &#8804; 10&#44; e doen&#231;a moderada a grave&#44; com escore PASI<span class="elsevierStyleHsp" style=""></span>&#62; 10&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Volunt&#225;rios saud&#225;veis pareados por idade e sexo&#44; sem quaisquer doen&#231;as inflamat&#243;rias sist&#234;micas&#44; incluindo doen&#231;as cardiovasculares e&#47;ou neurovasculares&#44; doen&#231;as inflamat&#243;rias da pele e ingest&#227;o regular de medicamentos por qualquer motivo&#44; foram inclu&#237;dos como grupo controle&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Altura&#44; peso&#44; circunfer&#234;ncia da cintura&#44; press&#227;o arterial &#40;PA&#41; diast&#243;lica e sist&#243;lica&#44; e pulsa&#231;&#227;o de todos os indiv&#237;duos foram medidos&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">SCUBE e outros testes laboratoriais</span><p id="par0050" class="elsevierStylePara elsevierViewall">Ap&#243;s 10 horas de jejum&#44; amostras de sangue venoso foram coletadas e colocadas em um tubo separador de soro com ativador de coagula&#231;&#227;o e centrifugadas a 3&#46;000<span class="elsevierStyleHsp" style=""></span>rpm por 10 minutos&#46; Em seguida&#44; essas amostras de soro foram armazenadas a<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>&#176;C at&#233; a an&#225;lise&#46; Testes bioqu&#237;micos&#44; incluindo glicemia de jejum&#44; triglicer&#237;deos &#40;TG&#41;&#44; colesterol total&#44; lipoprote&#237;na de alta densidade &#40;HDL&#41;&#44; lipoprote&#237;na de baixa densidade &#40;LDL&#41; e prote&#237;na C&#8208;reativa &#40;PCR&#41; foram medidos pelo analisador bioqu&#237;mico Beckman Coulter AU 5800 &#40;Beckman Coulter&#44; Brea&#44; CA&#44; EUA&#41;&#46; Os n&#237;veis s&#233;ricos de SCUBE&#8208;1 foram medidos utilizando o <span class="elsevierStyleItalic">kit</span> ELISA &#40;E&#8208;EL&#8208;H5405 Elabscience&#44; Wuhan&#44; Prov&#237;ncia de Hubei&#44; China&#41;&#46; A sensibilidade do <span class="elsevierStyleItalic">kit</span> ELISA era de 0&#44;38 ng&#47;mL&#46; Os resultados foram expressos em unidades de concentra&#231;&#227;o&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Medidas ultrassonogr&#225;ficas de EIMC</span><p id="par0055" class="elsevierStylePara elsevierViewall">Essas medidas foram realizadas pelo mesmo cardiologista certificado e treinado&#46; Os pacientes ficaram em repouso por 10 minutos e foram solicitados a deitar em dec&#250;bito dorsal durante o exame&#46; A ultrassonografia em modo B das art&#233;rias car&#243;tidas direita e esquerda foi realizada pelo m&#233;dico com um transdutor linear de alta resolu&#231;&#227;o &#40;sens&#237;vel a uma espessura de 0&#44;01<span class="elsevierStyleHsp" style=""></span>mm&#41; de 8<span class="elsevierStyleHsp" style=""></span>MHz do aparelho de ultrassom Vivid S6&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">An&#225;lise estat&#237;stica</span><p id="par0060" class="elsevierStylePara elsevierViewall">Os dados foram analisados usando o IBM SPSS Statistics 21&#46;0&#46; Os valores dos dados descritivos foram apresentados como m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP &#40;tamb&#233;m foram fornecidos mediana&#44; valores m&#237;nimos e m&#225;ximos&#41;&#46; As vari&#225;veis categ&#243;ricas foram apresentadas como frequ&#234;ncia e porcentagem&#46; Para a an&#225;lise de vari&#225;veis cont&#237;nuas entre os grupos&#44; as caracter&#237;sticas de distribui&#231;&#227;o foram avaliadas com o teste de Shapiro&#8208;Wilk&#46; A an&#225;lise do qui&#8208;quadrado foi usada para vari&#225;veis categ&#243;ricas e qualitativas&#44; e o teste <span class="elsevierStyleItalic">t</span> de Student tamb&#233;m foi empregado para compara&#231;&#245;es de vari&#225;veis com distribui&#231;&#227;o normal e o teste U de Mann&#8208;Whitney para vari&#225;veis n&#227;o normalmente distribu&#237;das&#44; se existissem dois grupos&#46; A rela&#231;&#227;o entre os par&#226;metros foi avaliada por meio da correla&#231;&#227;o e an&#225;lise de Pearson e Spearman&#46; As an&#225;lises de regress&#227;o log&#237;stica univariada e multivariada consistiram em SCUBE&#8208;1&#44; EIMC e outras vari&#225;veis &#40;PA sist&#243;lica&#44; circunfer&#234;ncia da cintura&#44; glicemia&#44; hs&#8208;PCR&#44; TG&#41;&#46; Signific&#226;ncia estat&#237;stica foi considerada com valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0065" class="elsevierStylePara elsevierViewall">Quarenta e seis pacientes &#40;19 mulheres e 27 homens&#41; com m&#233;dia de idade de 40&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;8 anos e 43 controles &#40;18 mulheres e 25 homens&#41; com m&#233;dia de idade de 39&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;6 anos foram inclu&#237;dos no estudo&#46; N&#227;o houve diferen&#231;a significante entre os dois grupos em rela&#231;&#227;o &#224; m&#233;dia de idade e sexo &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;890&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;958 respectivamente&#41;&#46; A dura&#231;&#227;o m&#233;dia da doen&#231;a dos pacientes foi de 12&#44;6 anos&#46; O escore PASI m&#233;dio foi de 12&#44;3 no grupo de pacientes&#46; Quinze pacientes tinham psor&#237;ase leve e 31 pacientes tinham psor&#237;ase moderada a grave&#44; de acordo com os escores PASI&#46; Os pacientes tinham IMC um pouco maior do que os controles&#44; com diferen&#231;a n&#227;o significante &#40;25&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;8<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span><span class="elsevierStyleItalic">vs</span>&#46; 24&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;2<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;154&#41;&#46; A PA sist&#243;lica m&#233;dia e a circunfer&#234;ncia da cintura foram maiores no grupo de pacientes&#44; e essas diferen&#231;as foram significantes &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;044 e p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#44; respectivamente&#41;&#46; As caracter&#237;sticas descritivas dos participantes s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Par&#226;metros laboratoriais</span><p id="par0070" class="elsevierStylePara elsevierViewall">Diferen&#231;as estatisticamente significantes foram demonstradas entre pacientes e controles saud&#225;veis em rela&#231;&#227;o aos n&#237;veis de glicemia de jejum&#44; TG e PCR &#40;para todos p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Todos esses par&#226;metros foram maiores no grupo de pacientes &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">N&#237;veis de SCUBE&#8208;1 e medidas da EIMC</span><p id="par0075" class="elsevierStylePara elsevierViewall">O valor m&#233;dio de SCUBE&#8208;1 nos pacientes foi de 4&#44;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;40&#44; enquanto no grupo controle foi de 2&#44;66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;49&#44; e essa foi uma diferen&#231;a significante &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Al&#233;m disso&#44; foram encontradas diferen&#231;as significantes entre os grupos em rela&#231;&#227;o &#224;s medidas da EIMC direita&#44; esquerda e m&#233;dia &#40;para todos&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#59; <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">N&#227;o foram mostradas diferen&#231;as significantes entre cada um dos valores de SCUBE&#8208;1 e medidas da EIMC de acordo com a gravidade da doen&#231;a com base nos escores PASI no grupo de pacientes &#40;para todos&#44; p<span class="elsevierStyleHsp" style=""></span>&#62; 0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Os valores de SCUBE&#8208;1 e EIMC foram correlacionados positivamente nos pacientes &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabela 5</a>&#41;&#46; Uma correla&#231;&#227;o positiva tamb&#233;m foi mostrada entre os n&#237;veis de SCUBE&#8208;1 e PA sist&#243;lica e diast&#243;lica&#46; Al&#233;m disso&#44; foram encontradas correla&#231;&#245;es positivas entre PA sist&#243;lica e diast&#243;lica&#44; IMC e circunfer&#234;ncia da cintura&#44; colesterol total e n&#237;veis de LDL &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabela 5</a>&#41;&#46; An&#225;lises de regress&#227;o linear m&#250;ltipla revelaram que a presen&#231;a de psor&#237;ase tamb&#233;m foi significantemente associada com EIMC e n&#237;veis de SCUBE&#8208;1 &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">tabela 6</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discuss&#227;o</span><p id="par0090" class="elsevierStylePara elsevierViewall">Evid&#234;ncias sugerem que al&#233;m da inflama&#231;&#227;o&#44; a angiog&#234;nese e a disfun&#231;&#227;o endotelial tamb&#233;m s&#227;o componentes significantes dos mecanismos patog&#234;nicos na psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">17&#44;18</span></a> A associa&#231;&#227;o entre psor&#237;ase e aumento do risco de doen&#231;as cardiovasculares foi comprovada em muitos estudos&#44;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">17&#44;19&#8208;22</span></a> mas os mecanismos subjacentes permanecem indefinidos&#46; Dois mecanismos subjacentes foram propostos&#58; primeiro&#44; fatores de risco cardiovascular no centro das aten&#231;&#245;es &#40;DM&#44; resist&#234;ncia &#224; insulina&#44; hipertens&#227;o&#44; perfis lip&#237;dicos alterados&#44; IMC alto&#44; tabagismo&#41; podem ser vistos com maior frequ&#234;ncia em pacientes com psor&#237;ase em compara&#231;&#227;o com o restante da popula&#231;&#227;o&#59;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">23&#44;24</span></a> o segundo &#233; a pr&#243;pria psor&#237;ase&#44; cuja inflama&#231;&#227;o sist&#234;mica tamb&#233;m pode afetar diretamente as paredes dos vasos e&#44; como resultado&#44; vasos inflamados elevam o risco de doen&#231;as cardiovasculares e mortalidade&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">25</span></a> Em um estudo de base populacional&#44; os autores mostraram que a psor&#237;ase estava associada ao aumento m&#233;dio da EIMC&#44; mas n&#227;o &#224; preval&#234;ncia de placa carot&#237;dea&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">26</span></a> Em outro estudo da It&#225;lia&#44; observou&#8208;se aumento significante nos valores m&#233;dios de EIMC em pacientes com psor&#237;ase&#44; al&#233;m de forte correla&#231;&#227;o positiva entre os escores PASI e EIMC&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">27</span></a> Semelhante &#224; literatura&#44; o presente estudo mostra diferen&#231;a significante nos valores de EIMC de pacientes com psor&#237;ase em rela&#231;&#227;o aos controles saud&#225;veis&#46; Al&#233;m disso&#44; PA sist&#243;lica e diast&#243;lica foram significantemente mais altas no grupo de pacientes&#44; enquanto ambos os grupos n&#227;o mostraram nenhuma diferen&#231;a em termos de h&#225;bitos de tabagismo e consumo de &#225;lcool e IMC&#46; Ao contr&#225;rio do estudo mencionado anteriormente&#44; n&#227;o foram encontradas diferen&#231;as significantes nos valores da EIMC de acordo com a gravidade da doen&#231;a&#44; nem correla&#231;&#227;o entre os valores da EIMC e os escores PASI&#46; Nossos resultados mostraram que mesmo pacientes com doen&#231;a leve podem ter maior risco de presen&#231;a de aterosclerose subcl&#237;nica e&#44; nos pacientes do presente estudo&#44; acredita&#8208;se que o poss&#237;vel mecanismo subjacente causador dessa diferen&#231;a esteja relacionado &#224; pr&#243;pria doen&#231;a&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">SCUBE&#8208;1 pertence &#224; fam&#237;lia de prote&#237;nas SCUBE que est&#227;o aumentadas em processos inflamat&#243;rios e condi&#231;&#245;es associadas &#224; hip&#243;xia&#44; e acredita&#8208;se que tenham papel na angiog&#234;nese fisiol&#243;gica e patol&#243;gica&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">28</span></a> Na literatura&#44; a express&#227;o de SCUBE&#8208;1 foi demonstrada especialmente em c&#233;lulas endoteliais vasculares de tecidos altamente vascularizados&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">8</span></a> e os n&#237;veis de SCUBE&#8208;1 estavam aumentados em condi&#231;&#245;es como s&#237;ndrome coronariana aguda&#44; acidente vascular encef&#225;lico isqu&#234;mico agudo&#44; DM&#44; neoplasias malignas e tamb&#233;m psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">9&#8211;11&#44;29&#44;30</span></a> Al&#233;m disso&#44; os n&#237;veis de SCUBE&#8208;1 diminu&#237;ram com tratamentos contra IL&#8208;1&#946; e TNF&#8208;&#945;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">8</span></a> At&#233; o momento&#44; h&#225; apenas um estudo avaliando os n&#237;veis de SCUBE&#8208;1 em pacientes com psor&#237;ase&#44; e esse estudo demonstrou que os n&#237;veis de VEGF&#44; SCUBE&#8208;1 e SCUBE&#8208;3 eram significantemente diferentes entre pacientes com psor&#237;ase e controles saud&#225;veis&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">12</span></a> Os autores tamb&#233;m relataram que SCUBE&#8208;1 apresentou 83&#37; de sensibilidade e 62&#37; de especificidade para prever a psor&#237;ase&#46; Assim&#44; eles sugeriram que a fam&#237;lia de prote&#237;nas SCUBE pode ser marcador potencial no processo e na triagem da angiog&#234;nese patol&#243;gica em pacientes psori&#225;sicos&#46; Da mesma maneira&#44; o presente estudo demonstrou n&#237;veis significantemente elevados de SCUBE&#8208;1 no grupo de pacientes em compara&#231;&#227;o aos controles saud&#225;veis&#46; A an&#225;lise de regress&#227;o m&#250;ltipla e os resultados de correla&#231;&#227;o entre EIMC e SCUBE&#8208;1 indicaram que o n&#237;vel de SCUBE&#8208;1 est&#225; fortemente associado &#224; aterosclerose e pode ser um biomarcador &#250;til e independente que demonstra a presen&#231;a de aterosclerose subcl&#237;nica&#44; al&#233;m da medida da EIMC&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">A PCR &#233; uma prote&#237;na de resposta de fase aguda envolvida em muitos processos inflamat&#243;rios&#44; como angiog&#234;nese&#44; trombose e ativa&#231;&#227;o do sistema complemento&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">31</span></a> Foi demonstrado que n&#237;veis elevados de PCR est&#227;o relacionados ao risco de eventos cardiovasculares futuros&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">32</span></a> O presente estudo mostrou n&#237;veis significantemente aumentados de PCR no grupo de pacientes&#44; o que pode demonstrar maior preval&#234;ncia de aterosclerose subjacente e dist&#250;rbios cardiovasculares em pacientes com psor&#237;ase&#46; A circunfer&#234;ncia da cintura &#233; um marcador cl&#237;nico de obesidade associado a aterosclerose e a dist&#250;rbios cardiovasculares&#46; Al&#233;m disso&#44; &#233; considerado medida n&#227;o invasiva independente da aterosclerose subcl&#237;nica&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">33</span></a> No presente estudo&#44; embora os pacientes tivessem IMC semelhante ao dos controles saud&#225;veis&#44; a medida da circunfer&#234;ncia da cintura era significantemente maior no grupo de pacientes&#46; Tamb&#233;m foi demonstrada correla&#231;&#227;o positiva entre a circunfer&#234;ncia da cintura e a PA&#46; Esses resultados sugerem que a medida da circunfer&#234;ncia da cintura tamb&#233;m &#233; um valor importante&#44; indicando aumento da PA e poss&#237;vel aterosclerose subcl&#237;nica&#44; mesmo que os pacientes n&#227;o sejam obesos&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclus&#227;o</span><p id="par0105" class="elsevierStylePara elsevierViewall">Embora o presente estudo tenha algumas limita&#231;&#245;es&#44; como baixo n&#250;mero de participantes e n&#227;o ter inclu&#237;do nenhum outro marcador inflamat&#243;rio relacionado &#224; angiog&#234;nese ou aterosclerose&#44; como VEGF&#44; adiponectina&#44; entre outros&#44; n&#227;o h&#225; nenhum outro estudo na literatura avaliando par&#226;metros metab&#243;licos&#44; SCUBE&#8208;1 s&#233;rico e medida da EIMC simultaneamente em pacientes com psor&#237;ase&#46; Com esses resultados&#44; os autores demostraram que al&#233;m da medida da EIMC&#44; SCUBE&#8208;1 pode ser marcador importante e independente para demonstrar aterosclerose subcl&#237;nica por meio de sua participa&#231;&#227;o no processo patol&#243;gico da angiog&#234;nese em pacientes com psor&#237;ase&#46; Al&#233;m disso&#44; os n&#237;veis s&#233;ricos de PCR e a circunfer&#234;ncia da cintura podem estar particularmente relacionados &#224; aterosclerose subcl&#237;nica e podem ser indicadores de futuras doen&#231;as cardiovasculares&#46; Este estudo pioneiro deve ser validado em futuros estudos longitudinais prospectivos com amostras maiores e mais marcadores inflamat&#243;rios&#46; Os autores acreditam que&#44; no futuro&#44; quando as vias e os mecanismos pelos quais a SCUBE&#8208;1 atua na patog&#234;nese da psor&#237;ase forem mais bem compreendidos&#44; ela poder&#225; ser um alvo potencial para futuras terap&#234;uticas&#44; especialmente para prevenir a angiog&#234;nese patol&#243;gica subjacente e a aterosclerose subcl&#237;nica na psor&#237;ase&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Suporte financeiro</span><p id="par0110" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Contribui&#231;&#227;o dos autores</span><p id="par0115" class="elsevierStylePara elsevierViewall">Havva Hilal Ayvaz &#199;elik&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Mevl&#252;t Serdar Kuyumcu&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica do manuscrito&#59; an&#225;lise estat&#237;stica&#59; concep&#231;&#227;o e planejamento do estudo&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Fevziye Burcu &#350;irin&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Mehmet Cirit&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Selma Korkmaz&#58; Revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">&#304;jlal Erturan&#58; Revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Seda &#199;elik&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Mehmet Y&#305;ld&#305;r&#305;m&#58; Revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflito de interesses</span><p id="par0155" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A psor&#237;ase &#233; doen&#231;a inflamat&#243;ria cr&#244;nica associada a muitas condi&#231;&#245;es inflamat&#243;rias&#44; como aterosclerose&#44; hipertens&#227;o&#44; entre outras&#46; SCUBE&#8208;1 &#233; uma prote&#237;na que desempenha pap&#233;is no processo de angiog&#234;nese&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O presente estudo teve como objetivo investigar se SCUBE&#8208;1 poderia indicar aterosclerose subcl&#237;nica em pacientes com psor&#237;ase e comparar os n&#237;veis de SCUBE&#8208;1&#44; a medida da espessura &#237;ntima&#8208;m&#233;dia carot&#237;dea &#40;EIMC&#41; e par&#226;metros metab&#243;licos em pacientes com psor&#237;ase e controles saud&#225;veis&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Quarenta e seis pacientes com psor&#237;ase e 43 controles saud&#225;veis foram inclu&#237;dos no estudo&#46; A gravidade da doen&#231;a foi avaliada com o escore &#205;ndice de &#193;rea e Gravidade da Psor&#237;ase &#40;PASI&#44; do ingl&#234;s <span class="elsevierStyleItalic">Psoriase Area Severity Index</span>&#41; no grupo de pacientes&#46; Os n&#237;veis de SCUBE&#8208;1&#44; prote&#237;na C&#8208;reativa &#40;PCR&#41;&#44; lip&#237;dios e glicemia de jejum foram medidos com o m&#233;todo <span class="elsevierStyleItalic">Enzyme&#8208;Linked Immunosorbent Assay</span> &#40;ELISA&#41;&#44; e as medidas de EIMC foram realizadas pelo mesmo cardiologista&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis de SCUBE&#8208;1 e os valores de EIMC foram significantemente maiores no grupo de pacientes &#40;para ambos&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Al&#233;m disso&#44; a press&#227;o arterial sist&#243;lica&#44; os n&#237;veis de PCR e a circunfer&#234;ncia da cintura foram maiores no grupo de pacientes&#44; embora ambos os grupos tivessem IMC semelhantes &#40;para todos&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Correla&#231;&#227;o positiva foi encontrada entre os valores de SCUBE&#8208;1 e EIMC nos pacientes&#44; e an&#225;lises de regress&#227;o m&#250;ltipla revelaram que SCUBE&#8208;1 e EIMC tamb&#233;m est&#227;o significantemente associados &#224; psor&#237;ase&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O baixo n&#250;mero de participantes e a n&#227;o inclus&#227;o de qualquer outro marcador inflamat&#243;rio relacionado &#224; angiog&#234;nese ou aterosclerose como VEGF&#44; adiponectina&#44; s&#227;o as principais limita&#231;&#245;es do presente estudo&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Sem considerar a gravidade da doen&#231;a&#44; mesmo em pacientes psori&#225;sicos com doen&#231;a leve&#44; o n&#237;vel de SCUBE&#8208;1 pode ser um indicador de aterosclerose subcl&#237;nica e indicar risco de doen&#231;a cardiovascular no futuro&#46;</p></span>"
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                  \t\t\t\t">25 &#40;54&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;46&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;460<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Etilismo&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;30&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;244<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Press&#227;o arterial sist&#243;lica&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;044<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Press&#227;o arterial diast&#243;lica&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;070<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulsa&#231;&#227;o&#44; por minuto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;067<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Circunfer&#234;ncia da cintura&#44; cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
              "identificador" => "tblfn0005"
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            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Qui&#8208;quadrado&#46;</p>"
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              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p>"
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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas basais dos grupos do estudo &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>89&#41;</p>"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Os dados s&#227;o fornecidos como m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>desvio padr&#227;o&#44; n&#250;mero &#40;n&#41;&#46; HDL&#44; lipoprote&#237;na de alta densidade&#8208;colesterol&#59; LDL&#44; lipoprote&#237;na de baixa densidade&#8208;colesterol&#59; Hs&#8208;PCR&#44; prote&#237;na C&#8208;reativa de alta sensibilidade&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupo de pacientes&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>46&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupo controle&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>43&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Glicemia&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>31&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;021<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colesterol total&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">191&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>36&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>36&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;365&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triglicer&#237;deos&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>67&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>46&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>27&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>27&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;088&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs&#8208;PCR&#44; mg&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              ]
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            0 => array:3 [
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              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; teste U de Mann&#8208;Whitney&#46;</p>"
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Par&#226;metros laboratoriais dos grupos do estudo &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>89&#41;</p>"
        ]
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                  \t\t\t\t">4&#44;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;44&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PA diast&#243;lica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Circunfer&#234;ncia da cintura&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Colesterol Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LDL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SCUBE1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">EIMC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PASI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="12" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">IMC</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sig&#46; &#40;bicaudal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="12" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="12" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dura&#231;&#227;o da doen&#231;a</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sig&#46; &#40;bicaudal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;389&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="12" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="12" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tabagismo</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8211;<span class="elsevierStyleHsp" style=""></span>0&#44;193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sig&#46; &#40;bicaudal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;906&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;199&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;778&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;658&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;171&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;255&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;585&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;213&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;079&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR &#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR &#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;970 &#40;0&#44;941&#8208;1&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;052&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;008<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;968 &#40;0&#44;919&#8208;1&#44;019&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;212&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Glicemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;965 &#40;0&#44;936&#8208;0&#44;994&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;019<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;996 &#40;0&#44;969&#8208;1&#44;023&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;764&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs&#8208;PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;733 &#40;0&#44;579&#8208;0&#44;927&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;010<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;848 &#40;0&#44;649&#8208;1&#44;107&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Triglicer&#237;deos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;988 &#40;0&#44;980&#8208;0&#44;996&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;992 &#40;0&#44;981&#8208;1&#44;003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;155&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">EIMC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;960 &#40;0&#44;940&#8208;0&#44;981&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;965 &#40;0&#44;945&#8208;0&#44;976&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;003<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">SCUBE&#8208;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;729 &#40;0&#44;598&#8208;0&#44;888&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;002<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;828 &#40;0&#44;652&#8208;1&#44;051&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;031<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                            0 => "P&#46; Gisondi"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin 17A&#58; toward a new understanding of psoriasis pathogenesis"
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                          "etal" => false
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                            0 => "C&#46;W&#46; Lynde"
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                            2 => "R&#46; Vender"
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                            4 => "S&#46; Khalil"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
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                      "titulo" => "Down&#8208;regulation of the Th1"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Luan"
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                            2 => "H&#46; Wang"
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                    0 => array:2 [
                      "doi" => "10.1016/j.intimp.2015.11.005"
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                        "tituloSerie" => "Th17&#44; and Th22 pathways due to anti&#8208;TNF&#8208;&#945; treatment in psoriasis&#46; Int Immunopharmacol&#46;"
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