array:23 [
  "pii" => "S2666275222002934"
  "issn" => "26662752"
  "doi" => "10.1016/j.abdp.2022.12.004"
  "estado" => "S300"
  "fechaPublicacion" => "2023-03-01"
  "aid" => "674"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "fla"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:18 [
      "pii" => "S0365059622002811"
      "issn" => "03650596"
      "doi" => "10.1016/j.abd.2022.03.007"
      "estado" => "S300"
      "fechaPublicacion" => "2023-03-01"
      "aid" => "674"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "fla"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Serum interleukin-6 levels are increased in post-herpetic neuralgia&#58; a single-center retrospective study"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "202"
            "paginaFinal" => "207"
          ]
        ]
        "contieneResumen" => array:1 [
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig0015"
            "etiqueta" => "Figure 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1772
                "Ancho" => 1680
                "Tamanyo" => 136096
              ]
            ]
            "detalles" => array:1 [
              0 => array:3 [
                "identificador" => "at0015"
                "detalle" => "Figure "
                "rol" => "short"
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Receiver operator curve of IL6 for postherpetic neuralgia&#46; The area under the curve values was 0&#46;896 &#40;95&#37; CI 0&#46;85&#8210;0&#46;95&#44; p&#8239;&#60;&#8239;0&#46;0001&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ding Lin, Changyang Zhong, Quanlong Jiang, Aihua Huang, Yuan Liu"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Ding"
                "apellidos" => "Lin"
              ]
              1 => array:2 [
                "nombre" => "Changyang"
                "apellidos" => "Zhong"
              ]
              2 => array:2 [
                "nombre" => "Quanlong"
                "apellidos" => "Jiang"
              ]
              3 => array:2 [
                "nombre" => "Aihua"
                "apellidos" => "Huang"
              ]
              4 => array:2 [
                "nombre" => "Yuan"
                "apellidos" => "Liu"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "pt" => array:9 [
          "pii" => "S2666275222002934"
          "doi" => "10.1016/j.abdp.2022.12.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "pt"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222002934?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002811?idApp=UINPBA00008Z"
      "url" => "/03650596/0000009800000002/v1_202302171515/S0365059622002811/v1_202302171515/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2666275222002880"
    "issn" => "26662752"
    "doi" => "10.1016/j.abdp.2022.11.033"
    "estado" => "S300"
    "fechaPublicacion" => "2023-03-01"
    "aid" => "669"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "pt" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
      "titulo" => "Achados da pele&#44; mucosa e unhas em pacientes pedi&#225;tricos hospitalizados com a doen&#231;a do coronav&#237;rus&#8208;2019 &#40;COVID&#8208;19&#41;"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "208"
          "paginaFinal" => "215"
        ]
      ]
      "contieneResumen" => array:1 [
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2000
              "Ancho" => 3341
              "Tamanyo" => 509952
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Alguns dos padr&#245;es de erup&#231;&#245;es cut&#226;neas no grupo de estudo&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Tun&#231; &#214;zen, Filiz Cebeci Kahraman, Sevliya &#214;cal, H&#252;sn&#252; Fahri Oval&#305;"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Tun&#231;"
              "apellidos" => "&#214;zen"
            ]
            1 => array:2 [
              "nombre" => "Filiz Cebeci"
              "apellidos" => "Kahraman"
            ]
            2 => array:2 [
              "nombre" => "Sevliya"
              "apellidos" => "&#214;cal"
            ]
            3 => array:2 [
              "nombre" => "H&#252;sn&#252; Fahri"
              "apellidos" => "Oval&#305;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0365059622002768"
        "doi" => "10.1016/j.abd.2022.03.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002768?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222002880?idApp=UINPBA00008Z"
    "url" => "/26662752/0000009800000002/v1_202302281436/S2666275222002880/v1_202302281436/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2666275222003113"
    "issn" => "26662752"
    "doi" => "10.1016/j.abdp.2022.12.022"
    "estado" => "S300"
    "fechaPublicacion" => "2023-03-01"
    "aid" => "692"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
      "titulo" => "Quantifica&#231;&#227;o dos poliomav&#237;rus humanos MCPyV e HPyV6 em les&#245;es cut&#226;neas malignas e n&#227;o malignas"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "198"
          "paginaFinal" => "201"
        ]
      ]
      "contieneResumen" => array:1 [
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marianna T&#46; Venceslau, Gabriella R&#46;M&#46; da Costa, Maria Angelica A&#46;M&#46; Guimar&#227;es, Rafael B&#46; Varella, Flavio B&#46; Luz"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Marianna T&#46;"
              "apellidos" => "Venceslau"
            ]
            1 => array:2 [
              "nombre" => "Gabriella R&#46;M&#46;"
              "apellidos" => "da Costa"
            ]
            2 => array:2 [
              "nombre" => "Maria Angelica A&#46;M&#46;"
              "apellidos" => "Guimar&#227;es"
            ]
            3 => array:2 [
              "nombre" => "Rafael B&#46;"
              "apellidos" => "Varella"
            ]
            4 => array:2 [
              "nombre" => "Flavio B&#46;"
              "apellidos" => "Luz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0365059622003130"
        "doi" => "10.1016/j.abd.2022.02.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622003130?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222003113?idApp=UINPBA00008Z"
    "url" => "/26662752/0000009800000002/v1_202302281436/S2666275222003113/v1_202302281436/pt/main.assets"
  ]
  "pt" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
    "titulo" => "N&#237;veis s&#233;ricos de interleucina&#8208;6 est&#227;o aumentados na neuralgia p&#243;s&#8208;herp&#233;tica&#58; estudo retrospectivo de centro &#250;nico"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "202"
        "paginaFinal" => "207"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ding Lin, Changyang Zhong, Quanlong Jiang, Aihua Huang, Yuan Liu, Yan Zhang"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "Ding"
            "apellidos" => "Lin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Changyang"
            "apellidos" => "Zhong"
            "email" => array:1 [
              0 => "zhongchangyang@aliyun.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Quanlong"
            "apellidos" => "Jiang"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Aihua"
            "apellidos" => "Huang"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Yuan"
            "apellidos" => "Liu"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Yan"
            "apellidos" => "Zhang"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Cardiologia&#44; Hangzhou Third People&#39;s Hospital&#44; Hangzhou&#44; China"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Doen&#231;as Cerebrovasculares&#44; Hangzhou Third People&#39;s Hospital&#44; Hangzhou&#44; China"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Hangzhou Binjiang District Changhe Street Community Health Service Center&#44; Hangzhou&#44; China"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspond&#234;ncia&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1093
            "Ancho" => 1672
            "Tamanyo" => 67362
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis s&#233;ricos de IL&#8208;6 nos grupos de NPH e volunt&#225;rios saud&#225;veis &#40;&#42;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">O v&#237;rus da varicela&#8208;z&#243;ster &#40;VZV&#41; &#233; um herpesv&#237;rus alfa humano&#46; Quando uma pessoa &#233; infectada pelo VZV pela primeira vez&#44; o que geralmente acontece na inf&#226;ncia&#44; ocorre a varicela&#46; O herpes&#8208;z&#243;ster &#40;HZ&#41; &#233; causado pela reativa&#231;&#227;o do VZV latente no nervo craniano ou g&#226;nglios da raiz dorsal na idade adulta&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a> possivelmente levando &#224; neuralgia p&#243;s&#8208;herp&#233;tica &#40;NPH&#41;&#46; Mesmo ap&#243;s a cura das les&#245;es cut&#226;neas&#44; a neuralgia cut&#226;nea local ainda persiste por meses ou anos&#44; ou at&#233; mesmo evolui para neuralgia refrat&#225;ria&#44; que ocorre frequentemente em pessoas de meia&#8208;idade e idosos e causa dor de longa dura&#231;&#227;o&#44; principalmente em mulheres idosas&#46; Al&#233;m disso&#44; a neuralgia refrat&#225;ria tamb&#233;m leva &#224; anorexia&#44; ins&#244;nia e depress&#227;o&#44; que causam s&#233;rio impacto na vida dos pacientes&#46; Estudos recentes mostraram que a NPH &#233; um tipo de dor neurop&#225;tica&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">2</span></a> e os fatores de risco da NPH incluem idade&#44; sexo&#44; sintomas precursores da erup&#231;&#227;o cut&#226;nea&#44; les&#227;o cut&#226;nea grave&#44; dor aguda grave e fatores psicossociais&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">3</span></a> A taxa de incid&#234;ncia de NPH &#233; de cerca de 2 a 4&#44;6 casos por 1&#46;000 pessoas por ano&#44; e essa taxa aumenta para 9&#44;1 casos por 1&#46;000 pessoas por ano na faixa et&#225;ria de 50 a 75 anos&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a> Estudos mostraram que a taxa geral de incid&#234;ncia de NPH na China &#233; de 6&#44;64 casos por 1&#46;000 pessoas&#46; Al&#233;m disso&#44; houve 99 epis&#243;dios recorrentes em 4&#46;313 epis&#243;dios prim&#225;rios de 2015 a 2017&#46; No entanto&#44; o n&#250;mero m&#233;dio de consultas de pacientes com doen&#231;a inicial foi significantemente menor do que o de pacientes recorrentes &#40;3&#44;6 <span class="elsevierStyleItalic">vs</span>&#46; 6&#44;7 por paciente&#41;&#44; e o tempo m&#233;dio de interna&#231;&#227;o de ataques recorrentes &#233; maior do que o do primeiro ataque&#46; Cerca de 9&#37; a 34&#37; dos pacientes desenvolver&#227;o NPH&#44; e as taxas de incid&#234;ncia e preval&#234;ncia aumentam gradualmente com a idade&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Apesar dos danos causados pela NPH&#44; o mecanismo da doen&#231;a permanece obscuro na China&#46; Atualmente&#44; biomarcadores eficazes para prever a NPH permanecem indispon&#237;veis&#44; o que dificulta a preven&#231;&#227;o da NPH e o sucesso de seu tratamento&#46; A rela&#231;&#227;o entre os n&#237;veis s&#233;ricos de citocinas e os graus de dor em pacientes com NPH foi investigada atrav&#233;s da observa&#231;&#227;o das altera&#231;&#245;es dos n&#237;veis s&#233;ricos de citocinas para descobrir os fatores imunol&#243;gicos que afetam o aparecimento da NPH&#44; estabelecendo assim as bases para a interven&#231;&#227;o cl&#237;nica precoce&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Pacientes e crit&#233;rios de elegibilidade</span><p id="par0015" class="elsevierStylePara elsevierViewall">Todos os participantes forneceram consentimento informado oral e por escrito antes de participar do estudo&#46; O desenho deste estudo est&#225; em conformidade com a Declara&#231;&#227;o de Helsinque&#44; e o estudo foi aprovado pelo Comit&#234; de &#201;tica Biom&#233;dica do Hangzhou Third People&#39;s Hospital&#46; Oitenta pacientes &#40;35 homens e 45 mulheres&#41; com NPH atendidos no hospital de abril de 2019 a outubro de 2021 foram considerados aptos para o estudo&#46; A idade dos pacientes variou de 40 a 85 anos&#44; com m&#233;dia de 68&#44;3<span class="elsevierStyleHsp" style=""></span>&#177; 10&#44;1 anos&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Crit&#233;rios de inclus&#227;o para pacientes com NPH&#58; 1&#41; A NPH no presente estudo refere&#8208;se a dor no local da erup&#231;&#227;o um m&#234;s ap&#243;s a cura do HZ&#44; de acordo com os crit&#233;rios diagn&#243;sticos de NPH&#59; 2&#41; os pacientes n&#227;o devem apresentar hist&#243;rico de doen&#231;as org&#226;nicas&#44; tais como doen&#231;as card&#237;acas&#44; pulmonares ou renais&#59; 3&#41; os pacientes n&#227;o devem apresentar nenhum d&#233;ficit na fun&#231;&#227;o cognitiva e na fala&#44; de acordo com os escores da escala Likert&#59; al&#233;m disso&#44; devem ser capazes de entender e aceitar seus escores na escala Likert&#59; 4&#41; os pacientes n&#227;o devem sofrer de outras doen&#231;as do sistema imunol&#243;gico&#44; c&#226;ncer&#44; infec&#231;&#245;es bacterianas ou apresentar outros sintomas relevantes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Crit&#233;rios de exclus&#227;o para pacientes com NPH&#58; 1&#41; pacientes com menos de 40 ou mais de 80&#59; 2&#41; pacientes com disfun&#231;&#227;o cognitiva e de linguagem ou incapazes de obter escores na escala Likert&#59; 3&#41; pacientes com c&#226;ncer ou doen&#231;as autoimunes&#59; 4&#41; uso recente de imunossupressores&#59; 5&#41; mulheres gr&#225;vidas e lactantes&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A escala Likert &#233; frequentemente utilizada em estudos cl&#237;nicos e relatos de casos de NPH&#46; A faixa da pontua&#231;&#227;o dessa escala &#233; de 0 &#40;totalmente indolor&#41; a 100 &#40;a dor mais intensa que pode ocorrer&#41;&#46; Clinicamente&#44; o limiar m&#237;nimo significante de NPH &#233; de 40 pontos&#46; Dor clinicamente significante indica que o escore da escala Likert &#233; superior a 40 pontos&#59; dor intensa indica que o escore da escala Likert &#233; maior que 70 pontos&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Os pacientes com NPH foram divididos em dois grupos de acordo com a escala Likert&#46; Pacientes com escore na escala Likert superior a 70 pontos foram definidos como NPH grave&#46; Aqueles com escore na escala Likert acima de 40 pontos foram definidos como NPH leve &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&#46; O grupo NPH foi definido pela escala Likert no dia da hospitaliza&#231;&#227;o&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Detec&#231;&#227;o de n&#237;veis s&#233;ricos de IL&#8208;6 e indicadores bioqu&#237;micos</span><p id="par0040" class="elsevierStylePara elsevierViewall">Para cada paciente&#44; 3<span class="elsevierStyleHsp" style=""></span>mL de sangue venoso foram coletados no segundo dia de hospitaliza&#231;&#227;o antes do tratamento&#46; Outros 3<span class="elsevierStyleHsp" style=""></span>mL de sangue venoso foram obtidos do paciente a partir do 14&#176; dia ap&#243;s o tratamento&#44; e todas as amostras de sangue foram colocadas em tubos com anticoagulante e enviadas ao banco de amostras do hospital para separa&#231;&#227;o e criopreserva&#231;&#227;o&#46; Os n&#237;veis s&#233;ricos de IL&#8208;6 foram medidos por ELISA sandu&#237;che de anticorpos m&#250;ltiplos&#46; O kit ELISA MCP&#8208;1&#47;IP&#8208;10&#47;rnaates&#47;fractalkine humano usado neste estudo foi adquirido da Genzyme&#44; EUA&#44; e o kit inclu&#237;a &#225;gua destilada&#44; um amostrador&#44; um oscilador e um agitador magn&#233;tico&#46; Os indicadores bioqu&#237;micos foram detectados por analisador bioqu&#237;mico autom&#225;tico no laborat&#243;rio cl&#237;nico do hospital&#44; incluindo triglic&#233;rides &#40;TG&#41;&#44; colesterol total &#40;CT&#41;&#44; fator de necrose tumoral&#8208;alfa &#40;TNF&#8208;&#945;&#41;&#44; colesterol lipoprote&#237;co de baixa densidade &#40;LDL&#8208;C&#41;&#44; e interleucina&#8208;10 &#40;IL&#8208;10&#41;&#46; As condi&#231;&#245;es dos pacientes ap&#243;s o tratamento foram avaliadas pelo escore da escala Likert&#46; A correla&#231;&#227;o entre os n&#237;veis s&#233;ricos de IL&#8208;6 na hospitaliza&#231;&#227;o e o escore da escala Likert ap&#243;s o tratamento tamb&#233;m foi analisada&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Todos os pacientes receberam doses apropriadas de gabapentina oral e 1&#46;000 ug de inje&#231;&#227;o intramuscular de mecobalamina diariamente&#46; Pacientes com dor intensa receberam adicionalmente doses apropriadas de comprimidos orais de libera&#231;&#227;o prolongada de cloridrato de oxicodona&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Coleta de dados cl&#237;nicos</span><p id="par0050" class="elsevierStylePara elsevierViewall">Hist&#243;rico m&#233;dico detalhado&#44; hist&#243;rico de medica&#231;&#227;o e o exame f&#237;sico foram realizados em todos os pacientes e volunt&#225;rios saud&#225;veis&#46; Os dados cl&#237;nicos inclu&#237;ram idade&#44; sexo&#44; hist&#243;rico de tabagismo&#44; hist&#243;rico de consumo de &#225;lcool e press&#227;o arterial&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">An&#225;lise estat&#237;stica</span><p id="par0055" class="elsevierStylePara elsevierViewall">As an&#225;lises estat&#237;sticas foram realizadas no software SPSS vers&#227;o 21&#46;0 &#40;International Business Machines&#44; Corp&#46;&#44; Armonk&#44; NY&#44; EUA&#41;&#46; As caracter&#237;sticas dos pacientes foram descritas como frequ&#234;ncias &#40;porcentagens&#41; ou m&#233;dias<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#46; Diferen&#231;as significantes entre os grupos foram avaliadas por an&#225;lise de vari&#226;ncia &#40;ANOVA&#41; unidirecional&#46; O teste de qui&#8208;quadrado foi utilizado para contagem dos dados&#46; A efici&#234;ncia diagn&#243;stica foi calculada pela curva caracter&#237;stica de opera&#231;&#227;o do receptor &#40;ROC&#41;&#59; o valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 foi considerado estatisticamente significante&#46; As figuras foram criadas com o software SPSS Statistics e GraphPad Prism 8&#46;0&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0060" class="elsevierStylePara elsevierViewall">Um total de 80 pacientes com NPH e 80 volunt&#225;rios saud&#225;veis foram inclu&#237;dos no presente estudo&#46; As caracter&#237;sticas dos pacientes e volunt&#225;rios s&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">N&#227;o houve diferen&#231;as significantes entre pacientes com NPH e volunt&#225;rios nas vari&#225;veis&#44; incluindo idade&#44; sexo&#44; n&#237;veis de TNF&#8208;&#945;&#44; CT&#44; TG&#44; IL&#8208;10 e LDL&#8208;C &#40;p<span class="elsevierStyleHsp" style=""></span>&#62; 0&#44;05&#44; respectivamente&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Houve diferen&#231;a significante nos n&#237;veis s&#233;ricos de IL&#8208;6 entre os grupos NPH leve e NPH grave&#44; e os pacientes do grupo NPH grave apresentaram n&#237;veis s&#233;ricos de IL&#8208;6 mais elevados do que os do grupo NPH leve &#40;10&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;97 <span class="elsevierStyleItalic">vs</span>&#46; 6&#44;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;25&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Pacientes com NPH grave ou leve apresentaram n&#237;veis s&#233;ricos de IL&#8208;6 mais elevados do que os volunt&#225;rios saud&#225;veis&#44; com p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Os n&#237;veis s&#233;ricos de IL&#8208;6 em pacientes com herpes&#8208;z&#243;ster foram maiores do que aqueles em volunt&#225;rios saud&#225;veis &#40;7&#44;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;15 <span class="elsevierStyleItalic">vs</span>&#46; 3&#44;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;02&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;00&#59; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">A curva ROC dos n&#237;veis de IL&#8208;6 para NPH &#233; mostrada na <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a>&#46; O valor da &#225;rea sob a curva &#40;AUC&#44; <span class="elsevierStyleItalic">area under the curve</span>&#41; foi de 0&#44;896 &#40;intervalo de confian&#231;a de 95&#37;&#58; 0&#44;85&#8208;0&#44;95&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; De acordo com a curva ROC&#44; o valor de corte dos n&#237;veis s&#233;ricos de IL&#8208;6 para NPH foi de 4&#44;95 pg&#47;mL&#44; com sensibilidade de 80&#37; e especificidade de 86&#44;2&#37;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">No grupo NPH&#44; uma dose apropriada de gabapentina foi administrada por via oral com base nas condi&#231;&#245;es do paciente&#44; e mecobalamina foi administrada atrav&#233;s de inje&#231;&#245;es intramusculares em uma dose di&#225;ria&#46; Ap&#243;s o 14&#176; dia de tratamento&#44; todos os pacientes com NPH foram avaliados pelo escore da escala Likert&#46; Os resultados s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46; Os n&#237;veis s&#233;ricos de IL&#8208;6 na hospitaliza&#231;&#227;o foram associados ao escore da escala Likert ap&#243;s o 14&#176; dia de tratamento &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discuss&#227;o</span><p id="par0085" class="elsevierStylePara elsevierViewall">A NPH &#233; um tipo de dor neurop&#225;tica refrat&#225;ria&#46; Nos &#250;ltimos anos&#44; estudos mostraram que a NPH pode causar danos ao sistema nervoso&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> A doen&#231;a pode apresentar uma variedade de sintomas sist&#234;micos&#44; incluindo fadiga cr&#244;nica&#44; anorexia&#44; perda ponderal&#44; falta de atividade e ins&#244;nia&#44; acompanhados por altera&#231;&#245;es emocionais ou psicol&#243;gicas&#44; como ansiedade&#44; depress&#227;o&#44; desaten&#231;&#227;o etc&#46;&#59; alguns pacientes apresentam tend&#234;ncias suicidas&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> Na China&#44; foi relatado que cerca de 45&#37; dos pacientes com NPH sofreram interfer&#234;ncia emocional moderada a grave&#44; 40&#37; dos pacientes com NPH sofreram interfer&#234;ncia moderada a grave em suas atividades da vida di&#225;ria&#44; mais de 40&#37; dos pacientes tiveram dist&#250;rbios do sono moderados a graves e 59&#44;68&#37; dos pacientes tinham ou frequentemente tiveram pensamentos suicidas&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> Tamb&#233;m &#233; relatado na literatura estrangeira que quanto mais intensa a dor&#44; mais grave o impacto na energia&#44; no sono e na qualidade de vida geral dos pacientes&#46; Al&#233;m disso&#44; a NPH pode ter impacto moderado a grave na vida dos membros da fam&#237;lia&#44; causando fadiga&#44; estresse&#44; ins&#244;nia e sofrimento emocional&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Foi demonstrado que v&#225;rios processos inflamat&#243;rios est&#227;o envolvidos na dor neurop&#225;tica&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> Especificamente&#44; as citocinas s&#227;o capazes de regular diversas fun&#231;&#245;es fisiol&#243;gicas celulares&#46; Elas s&#227;o polipept&#237;dios com pequenos pesos moleculares que s&#227;o sintetizados e secretados por todos os tipos de c&#233;lulas do corpo&#44; desempenhando importante papel nos processos de estresse causados por trauma&#44; dor e infec&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> Atualmente&#44; v&#225;rios tipos de citocinas s&#227;o conhecidas&#44; incluindo a interleucina &#40;IL&#41;&#44; o interferon &#40;IFN&#41;&#44; o fator estimulante de col&#244;nias &#40;CSF&#41;&#44; o fator de necrose tumoral &#40;TNF&#41;&#44; o fator de crescimento neural &#40;NGF&#41; e o fator de crescimento transformador &#40;TGF&#41;&#46; Elas est&#227;o envolvidas na regula&#231;&#227;o da homeostase no sistema imunol&#243;gico e&#44; se houver estresse excessivo&#44; rea&#231;&#245;es patol&#243;gicas ocorrer&#227;o&#46; Estudos anteriores mostraram que as citocinas podem ser categorizadas como pr&#243;&#8208;inflamat&#243;rias ou anti&#8208;inflamat&#243;rias&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a> As primeiras incluem IL&#8208;6&#44; IL&#8208;1&#44; IL&#8208;8 e TNF&#44; enquanto as &#250;ltimas incluem IL&#8208;4&#44; IL&#8208;10&#44; antagonista do receptor de IL&#8208;2 sol&#250;vel e TNF&#46; Em condi&#231;&#245;es fisiol&#243;gicas normais&#44; esses dois tipos de citocinas mant&#234;m bom equil&#237;brio com a ajuda de regula&#231;&#245;es neuroend&#243;crinas e humorais&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> Vale ressaltar que a IL&#8208;6 &#233; uma citocina multi&#8208;efetora produzida por c&#233;lulas Th2&#44; macr&#243;fagos&#8208;mon&#243;citos e c&#233;lulas endoteliais&#46; &#201; uma mol&#233;cula crucial na resposta imune&#44; resposta de fase aguda e regula&#231;&#227;o hematopoi&#233;tica&#46; Al&#233;m disso&#44; como fator de diferencia&#231;&#227;o e crescimento de c&#233;lulas B&#44; c&#233;lulas T e c&#233;lulas endoteliais&#44; a IL&#8208;6 pode ativar genes&#8208;alvo&#44; participar da imunidade humoral&#44; induzir a matura&#231;&#227;o de megacari&#243;citos e atuar no crescimento&#44; na diferencia&#231;&#227;o&#44; regenera&#231;&#227;o e degrada&#231;&#227;o de c&#233;lulas nervosas nos sistemas nervosos perif&#233;rico e central&#46; Em condi&#231;&#245;es fisiol&#243;gicas normais&#44; o conte&#250;do de IL&#8208;6 secretado por macr&#243;fagos&#44; mast&#243;citos&#44; linf&#243;citos&#44; neur&#244;nios e c&#233;lulas gliais est&#225; em n&#237;vel baixo&#44; o que facilita o desenvolvimento normal e o reparo do sistema nervoso&#44; enquanto alto n&#237;vel de IL&#8208;6 pode causar danos ao sistema nervoso&#46; Os estudiosos tamb&#233;m descobriram que o n&#237;vel de IL&#8208;6 em pacientes com NPH ou neuralgia posterior foi positivamente correlacionado com perda sensorial e perda de sensa&#231;&#227;o de frio na &#225;rea da dor&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">15&#8211;19</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Com a les&#227;o do nervo perif&#233;rico&#44; a express&#227;o de IL&#8208;6 e receptores da IL&#8208;6 na medula espinhal &#233; regulada positivamente&#46; Em experimentos com animais&#44; inje&#231;&#245;es de IL&#8208;6 em ratos normais podem inibir suas respostas &#224; estimula&#231;&#227;o t&#233;rmica e mec&#226;nica&#46; Mesmo quando as respostas &#224; dor causadas pela estimula&#231;&#227;o mec&#226;nica foram preservadas&#44; as inje&#231;&#245;es de IL&#8208;6 ainda foram capazes de inibir as respostas &#224; dor causadas pela estimula&#231;&#227;o t&#233;rmica&#46; Portanto&#44; verificou&#8208;se que a IL&#8208;6 desempenha papel importante na dor persistente resultante da les&#227;o de nervos perif&#233;ricos e centrais&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">20&#44;21</span></a> Al&#233;m disso&#44; Arruda et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">22</span></a> realizaram v&#225;rios experimentos em animais&#44; nos quais anticorpos IL&#8208;6 ou IgG alog&#234;nica foram aplicados para tratar ratos com hiperalgesia persistente devido a les&#227;o de nervo perif&#233;rico&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">No presente estudo&#44; verificou&#8208;se que o n&#237;vel s&#233;rico de IL&#8208;6 correlacionou&#8208;se positivamente com o escore da escala Likert&#44; sugerindo o papel da IL&#8208;6 na progress&#227;o patol&#243;gica da NPH&#46; Algumas citocinas&#44; como IFN&#8208;&#947;&#44; IL&#8208;6 e IL&#8208;8&#44; estavam levemente aumentadas no grupo z&#243;ster em compara&#231;&#227;o com um grupo de indiv&#237;duos saud&#225;veis normais de distribui&#231;&#227;o et&#225;ria semelhante&#59; essas diferen&#231;as apenas se aproximaram da signific&#226;ncia&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a> Foi parcialmente consistente com o presente estudo&#44; mas esse estudo confirmou ainda que a IL&#8208;6 estava intimamente relacionada &#224; NPH por meio de agrupamento estratificado&#46; No presente estudo&#44; o n&#237;vel s&#233;rico de IL&#8208;6 em pacientes com NPH grave foi significantemente mais alto do que em pacientes com NPH leve ou no grupo controle saud&#225;vel&#44; e foi maior em pacientes com NPH grave do que em pacientes com NPH leve&#44; sugerindo que pacientes com NPH e altos n&#237;veis de IL&#8208;6 eram mais propensos a desenvolver NPH grave&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">No presente estudo&#44; o n&#237;vel s&#233;rico de IL&#8208;6 mostrou diferen&#231;a estatisticamente significante entre os pacientes com NPH antes e ap&#243;s o tratamento&#46; No estudo de Saxena AK et al&#46;&#44; o tratamento da neuralgia do herpes&#8208;z&#243;ster incluiu terapia cognitivo&#8208;comportamental &#40;TCC&#41; juntamente com pregabalina&#46; O efeito de al&#237;vio da dor foi not&#225;vel&#44; e uma regula&#231;&#227;o negativa significante da express&#227;o de mRNA da IL&#8208;6 foi observada&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a> Resultados consistentes foram confirmados em popula&#231;&#245;es do Leste e do Oeste Asi&#225;ticos&#46; No entanto&#44; n&#227;o foi demonstrado que o n&#237;vel de IL&#8208;6 esteja intimamente relacionado ao progn&#243;stico da NPH&#46; O presente estudo constatou que os n&#237;veis s&#233;ricos de IL&#8208;6 em pacientes com NPH na hospitaliza&#231;&#227;o est&#227;o correlacionados com o escore na escala Likert no 14&#176; dia ap&#243;s o diagn&#243;stico&#46; &#201; sugerido que os n&#237;veis s&#233;ricos de IL&#8208;6 em pacientes com NPH na hospitaliza&#231;&#227;o possam ser fator preditivo para o progn&#243;stico de curto prazo&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A IL&#8208;6 s&#233;rica pode ser indicador diagn&#243;stico de NPH com sensibilidade de 85&#37; e especificidade de 87&#44;5&#37;&#46; A possibilidade do herpes&#8208;z&#243;ster evoluir para neuralgia do herpes&#8208;z&#243;ster pode ser considerada precocemente pelo n&#237;vel de IL&#8208;6&#46; Interven&#231;&#227;o precoce e tratamento regular para pacientes com n&#237;veis elevados de IL&#8208;6 podem ajudar a aliviar a dor e melhorar sua qualidade de vida&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclus&#245;es</span><p id="par0115" class="elsevierStylePara elsevierViewall">O n&#237;vel s&#233;rico de IL&#8208;6 est&#225; relacionado com o grau de neuralgia herp&#233;tica e pode ser um biomarcador para o diagn&#243;stico de NPH&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Suporte financeiro</span><p id="par0120" class="elsevierStylePara elsevierViewall">Zhejiang Provincial Health Science and Technology Project 2022KY977&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Contribui&#231;&#227;o dos autores</span><p id="par0125" class="elsevierStylePara elsevierViewall">Ding Lin&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o de dados</p><p id="par0130" class="elsevierStylePara elsevierViewall">Changyang Zhong&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Quanlong Jiang&#58; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Aihua Huang&#58; Participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Yuan Liu&#58; Elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; an&#225;lise estat&#237;stica&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Yan Zhang&#58; Concep&#231;&#227;o e planejamento do estudo&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflito de interesses</span><p id="par0155" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres1855375"
          "titulo" => "Resumo"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Fundamentos"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "M&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Resultados"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Limita&#231;&#245;es do estudo"
            ]
            5 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Conclus&#245;es"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1613139"
          "titulo" => "Palavras&#8208;chave"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introdu&#231;&#227;o"
        ]
        3 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "M&#233;todos"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Pacientes e crit&#233;rios de elegibilidade"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Detec&#231;&#227;o de n&#237;veis s&#233;ricos de IL&#8208;6 e indicadores bioqu&#237;micos"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Coleta de dados cl&#237;nicos"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "An&#225;lise estat&#237;stica"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Resultados"
        ]
        5 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Discuss&#227;o"
        ]
        6 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conclus&#245;es"
        ]
        7 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Suporte financeiro"
        ]
        8 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Contribui&#231;&#227;o dos autores"
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conflito de interesses"
        ]
        10 => array:1 [
          "titulo" => "Refer&#234;ncias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2022-01-23"
    "fechaAceptado" => "2022-03-07"
    "PalabrasClave" => array:1 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras&#8208;chave"
          "identificador" => "xpalclavsec1613139"
          "palabras" => array:3 [
            0 => "Herpes&#8208;z&#243;ster"
            1 => "Interleucina&#8208;6"
            2 => "Neuralgia p&#243;s&#8208;herp&#233;tica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudos t&#234;m demonstrado que a taxa de incid&#234;ncia global de herpes&#8208;z&#243;ster &#40;HZ&#41; na China &#233; de 6&#44;64 casos por 1&#46;000 pessoas&#59; apesar dos agravos causados pela neuralgia p&#243;s&#8208;herp&#233;tica &#40;NPH&#41;&#44; o mecanismo da doen&#231;a ainda n&#227;o est&#225; claro na China&#46; Atualmente&#44; biomarcadores eficazes para prever a NPH permanecem indispon&#237;veis&#44; o que dificulta a preven&#231;&#227;o da NPH e o sucesso de seu tratamento&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O objetivo do estudo foi determinar o n&#237;vel s&#233;rico de interleucina&#8208;6 &#40;IL&#8208;6&#41; na NPH&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis s&#233;ricos de IL&#8208;6 foram medidos por ELISA sandu&#237;che de anticorpos m&#250;ltiplos&#46; A escala Likert foi utilizada para representar o grau de neuralgia nos pacientes&#46; Aqueles com NPH foram divididos em grupo NPH leve e grupo NPH grave&#44; de acordo com a escala de Likert&#46; A curva ROC foi realizada para avaliar a efici&#234;ncia diagn&#243;stica da IL&#8208;6 para NPH&#46; A correla&#231;&#227;o entre o n&#237;vel de IL&#8208;6 e a escala Likert antes e ap&#243;s o tratamento com gabapentina e mecobalamina foi analisada&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis de IL&#8208;6 em pacientes com NPH mostraram resultados mais elevados em rela&#231;&#227;o aos volunt&#225;rios&#46; Os pacientes do grupo NPH grave apresentaram n&#237;veis s&#233;ricos de IL&#8208;6 mais elevados do que o grupo NPH leve&#46; O escore na escala Likert estava relacionado com os n&#237;veis s&#233;ricos de IL&#8208;6 e a frequ&#234;ncia de n&#237;veis de IL&#8208;6 acima do valor de corte &#40;4&#44;95 pg&#47;mL&#41; nos grupos NPH antes e ap&#243;s o tratamento &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A dor &#233; subjetiva&#46; Alguns estados mentais&#44; como ansiedade e depress&#227;o&#44; influenciam muito a percep&#231;&#227;o individual da dor&#44; e a toler&#226;ncia &#224; dor pode variar entre as pessoas&#46; Portanto&#44; os escores de dor podem ser afetados por diferentes fatores individuais&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis s&#233;ricos de IL&#8208;6 podem ser utilizados como indicadores bioqu&#237;micos da gravidade da NPH&#46;</p></span>"
        "secciones" => array:6 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Fundamentos"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Limita&#231;&#245;es do estudo"
          ]
          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Conclus&#245;es"
          ]
        ]
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Lin D&#44; Zhong C&#44; Jiang Q&#44; Huang A&#44; Liu Y&#44; Zhang Y&#46; Serum interleukin&#8208;6 levels are increased in post&#8208;herpetic neuralgia&#58; a single&#8208;center retrospective study&#46; An Bras Dermatol&#46; 2023&#59;98&#58;203&#8211;8&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Trabalho realizado no Hangzhou Third People&#39;s Hospital e laborat&#243;rio cl&#237;nico&#44; Hangzhou Third People&#39;s Hospital&#44; Hangzhou&#44; China&#46;</p>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1704
            "Ancho" => 1512
            "Tamanyo" => 101340
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis s&#233;ricos de IL&#8208;6 nos grupos de NPH leve&#44; NPH grave e volunt&#225;rios saud&#225;veis &#40;&#42;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1093
            "Ancho" => 1672
            "Tamanyo" => 67362
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis s&#233;ricos de IL&#8208;6 nos grupos de NPH e volunt&#225;rios saud&#225;veis &#40;&#42;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1754
            "Ancho" => 1640
            "Tamanyo" => 132609
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Curva caracter&#237;stica de opera&#231;&#227;o do receptor &#40;ROC&#41; de IL&#8208;6 para NPH&#46; O valor da &#225;rea sob a curva foi de 0&#44;896 &#40;IC95&#37;&#58; 0&#44;85&#8208;0&#44;95&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">TG&#44; triglic&#233;rides&#59; CT&#44; colesterol total&#59; LDL&#8208;C&#44; colesterol lipoproteico de baixa densidade&#59; IL&#8208;10&#44; interleucina&#8208;10&#59; TNF&#8208;&#945;&#44; fator de necrose tumoral&#8208;&#945;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;sticas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neuralgia p&#243;s&#8208;herp&#233;tica leve &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neuralgia p&#243;s&#8208;herp&#233;tica grave &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Volunt&#225;rios saud&#225;veis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Escore na escala</span><span class="elsevierStyleItalic">Likert</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#47;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de &#225;lcool</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tabagismo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hipertens&#227;o</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#47;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#47;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">CT &#40;mmoL&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;52<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;69<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">IL&#8208;10 &#40;pg&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TG &#40;mmoL&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;21<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TNF&#8208;&#945; &#40;pg&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">LDL&#8208;C &#40;mmoL&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Informa&#231;&#245;es cl&#237;nicas detalhadas de pacientes com neuralgia p&#243;s&#8208;herp&#233;tica e volunt&#225;rios saud&#225;veis&#46; &#40;M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#41;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Pacientes com escore na escala Likert superior a 70 pontos foram definidos como NPH grave&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Aqueles com escore na escala Likert acima de 40 pontos foram definidos como NPH leve&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">O valor de corte dos n&#237;veis s&#233;ricos de IL6 para NPH foi de 4&#44;95 pg&#47;mL&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Escore na Escala Likert &#40;pontos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">0&#8208;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">40&#8208;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#8805; 70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Na hospitaliza&#231;&#227;o</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Paciente &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#237;vel de IL&#8208;6 s&#233;rica &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IL&#8208;6 s&#233;rica &#8805; 4&#44;95 pg&#47;mL &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;72&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#40;92&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">14 dias ap&#243;s o tratamento</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Paciente &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#237;vel de IL&#8208;6 s&#233;rica &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IL&#8208;6 s&#233;rica &#8805; 4&#44;95 pg&#47;mL &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;21&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;93&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Antes e ap&#243;s 14 dias de tratamento&#44; os n&#237;veis s&#233;ricos de IL&#8208;6 em cada grupo foram correlacionados com o escore na Escala Likert</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Varicella&#8208;zoster virus&#46; The Fourteenth Fleming lecture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;J&#46; Davison"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1099/0022-1317-72-3-475"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gen Virol&#46;"
                        "fecha" => "1991"
                        "volumen" => "72"
                        "paginaInicial" => "475"
                        "paginaFinal" => "486"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1848588"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of shingles&#58; Head and Campbell&#39;s 1900 monograph"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;L&#46; Oaklander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archneur.56.10.1292"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol&#46;"
                        "fecha" => "1999"
                        "volumen" => "56"
                        "paginaInicial" => "1292"
                        "paginaFinal" => "1294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10520948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy Mayo Clinic Proceedings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Ghanavatian"
                            1 => "C&#46;S&#46; Wie"
                            2 => "R&#46;S&#46; Low"
                            3 => "N&#46; Zhang"
                            4 => "J&#46;M&#46; Montoya"
                            5 => "G&#46;S&#46; Dhaliwal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.mayocp.2018.11.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc&#46;"
                        "fecha" => "2019"
                        "volumen" => "94"
                        "paginaInicial" => "484"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30718068"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pain&#44; itch&#44; quality of life&#44; and costs after herpes zoster"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;J&#46;M&#46; van Wijck"
                            1 => "Y&#46;R&#46; Aerssens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/papr.12518"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pain Pract&#46;"
                        "fecha" => "2017"
                        "volumen" => "17"
                        "paginaInicial" => "738"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27611885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and disease burden of herpes zoster in the population aged &#8805;50 years in China&#58; data from an integrated health care network"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "X&#46; Sun"
                            1 => "Z&#46; Wei"
                            2 => "H&#46; Lin"
                            3 => "M&#46; Jit"
                            4 => "Z&#46; Li"
                            5 => "C&#46; Fu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jinf.2021.03.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect&#46;"
                        "fecha" => "2021"
                        "volumen" => "82"
                        "paginaInicial" => "253"
                        "paginaFinal" => "260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33774019"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice&#46; Postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;W&#46; Johnson"
                            1 => "A&#46;S&#46;C&#46; Rice"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMcp1403062"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2014"
                        "volumen" => "371"
                        "paginaInicial" => "1526"
                        "paginaFinal" => "1533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25317872"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of sympathetic nerve blocks in herpes zoster and postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;L&#46; Wu"
                            1 => "A&#46; Marsh"
                            2 => "R&#46;H&#46; Dworkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pain&#46;"
                        "fecha" => "2000"
                        "volumen" => "87"
                        "paginaInicial" => "121"
                        "paginaFinal" => "129"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of herpes zoster and post&#8208;herpetic neuralgia on health&#8208;related quality of life in Japanese adults aged 60 years or older&#58; results from a prospective&#44; observational cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Mizukami"
                            1 => "K&#46; Sato"
                            2 => "K&#46; Adachi"
                            3 => "S&#46; Matthews"
                            4 => "K&#46; Holl"
                            5 => "T&#46; Matsuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s40261-017-0581-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Drug Investig&#46;"
                        "fecha" => "2018"
                        "volumen" => "38"
                        "paginaInicial" => "29"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29086340"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical investigation and analysis of postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;Y&#46; Wang"
                            1 => "Bao Jia-jin"
                            2 => "Wei Xing"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chin J Pain Med&#46;"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "198"
                        "paginaFinal" => "200"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pain&#44; medication use&#44; and health&#8208;related quality of life in older persons with postherpetic neuralgia&#58; results from a population&#8208;based survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; Oster"
                            1 => "G&#46; Harding"
                            2 => "E&#46; Dukes"
                            3 => "J&#46; Edelsberg"
                            4 => "P&#46;D&#46; Cleary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpain.2005.01.359"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pain&#46;"
                        "fecha" => "2005"
                        "volumen" => "6"
                        "paginaInicial" => "356"
                        "paginaFinal" => "363"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15943957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A meta&#8208;analysis of stroke risk following herpes zoster infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46; Marra"
                            1 => "J&#46; Ruckenstein"
                            2 => "K&#46; Richardson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12879-016-2122-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Infect Dis&#46;"
                        "fecha" => "2017"
                        "volumen" => "17"
                        "paginaInicial" => "1"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28049444"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytokines and chemokines at the crossroads of neuroinflammation&#44; neurodegeneration&#44; and neuropathic pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Ramesh"
                            1 => "A&#46;G&#46; MacLean"
                            2 => "M&#46;T&#46; Philipp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2013/480739"
                      "Revista" => array:5 [
                        "tituloSerie" => "Mediators Inflamm&#46;"
                        "fecha" => "2013"
                        "volumen" => "2013"
                        "paginaInicial" => "480739"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23997430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of cytokines in acute neurodegeneration in the CNS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;J&#46; Rothwell"
                            1 => "J&#46;K&#46; Relton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0149-7634(05)80152-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosci Biobehav Rev&#46;"
                        "fecha" => "1993"
                        "volumen" => "17"
                        "paginaInicial" => "217"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8515904"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Study on the related factors of post&#8208;herpetic neuralgia in hospitalized patients with herpes zoster in Sichuan Hospital of Traditional Chinese Medicine based on big data analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Li"
                            1 => "J&#46; Wang"
                            2 => "H&#46; Xie"
                            3 => "P&#46; Hao"
                            4 => "C&#46; Qing"
                            5 => "Y&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.14410"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2020"
                        "volumen" => "33"
                        "paginaInicial" => "e14410"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33052606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL&#8208;6 contributes to corneal nerve degeneration after herpes simplex virus type I infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;J&#46; Chucair-Elliott"
                            1 => "J&#46; Jinkins"
                            2 => "M&#46;M&#46; Carr"
                            3 => "D&#46;J&#46;J&#46; Carr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajpath.2016.06.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol&#46;"
                        "fecha" => "2016"
                        "volumen" => "186"
                        "paginaInicial" => "2665"
                        "paginaFinal" => "2678"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27497323"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral Chinese herbal medicine for post&#8208;herpetic neuralgia&#58; A systematic review and meta&#8208;analysis of randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Liang"
                            1 => "M&#46;E&#46; Coyle"
                            2 => "K&#46; Wang"
                            3 => "A&#46;L&#46; Zhang"
                            4 => "X&#46; Guo"
                            5 => "H&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "European Journal of Integrative Medicine&#46;"
                        "fecha" => "2017"
                        "volumen" => "10"
                        "paginaInicial" => "46"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interventional treatments for postherpetic neuralgia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;S&#46; Lin"
                            1 => "Y&#46;C&#46; Lin"
                            2 => "H&#46;C&#46; Lao"
                            3 => "C&#46;C&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pain Physician&#46;"
                        "fecha" => "2019"
                        "volumen" => "22"
                        "paginaInicial" => "209"
                        "paginaFinal" => "228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31151330"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Up&#8208;date on clinical management of postherpetic neuralgia and mechanism&#8208;based treatment&#58; new options in therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Forstenpointner"
                            1 => "A&#46;S&#46;C&#46; Rice"
                            2 => "N&#46;B&#46; Finnerup"
                            3 => "R&#46; Baron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect Dis&#46;"
                        "fecha" => "2018"
                        "volumen" => "218"
                        "numero" => "suppl&#95;2"
                        "paginaInicial" => "S120"
                        "paginaFinal" => "S126"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Relationship between the Level of Serum IL&#8208;6 and the Injury of Never System in Patients with Postherpetic Neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Chen"
                            1 => "P&#46; Xie"
                            2 => "D&#46; Zou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Chin J Neuroimmunol Neurol&#46;"
                        "fecha" => "2005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of galanin on neuropathic pain in streptozotocin&#8208;induced diabetic rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Xu"
                            1 => "Z&#46; Liu"
                            2 => "H&#46; Liu"
                            3 => "X&#46; Yang"
                            4 => "Z&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejphar.2012.01.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Pharmacol&#46;"
                        "fecha" => "2012"
                        "volumen" => "680"
                        "paginaInicial" => "28"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22306246"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of extracts from rabbit skin inflamed by vaccinia virus in the management of postherpetic neuralgia and on serum interleukin&#8208;6 level in aged patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "X&#46;M&#46; Yang"
                            1 => "R&#46;G&#46; He"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nan Fang Yi Ke Da Xue Xue Bao&#46;"
                        "fecha" => "2007"
                        "volumen" => "27"
                        "paginaInicial" => "1941"
                        "paginaFinal" => "1943"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18159027"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intrathecal anti&#8208;IL&#8208;6 antibody and IgG attenuates peripheral nerve injury&#8208;induced mechanical allodynia in the rat&#58; possible immune modulation in neuropathic pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;L&#46; Arruda"
                            1 => "S&#46; Sweitzer"
                            2 => "M&#46;D&#46; Rutkowski"
                            3 => "J&#46;A&#46; DeLeo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Brain Res&#46;"
                        "fecha" => "2000"
                        "volumen" => "879"
                        "paginaInicial" => "216"
                        "paginaFinal" => "225"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Local immune responses and systemic cytokine responses in zoster&#58; relationship to the development of postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Zak-Prelich"
                            1 => "R&#46;C&#46; McKenzie"
                            2 => "A&#46; Sysa-Jedrzejowska"
                            3 => "M&#46; Norval"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-2249.2003.02061.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol&#46;"
                        "fecha" => "2003"
                        "volumen" => "131"
                        "paginaInicial" => "318"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12562395"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modulation of mRNA Expression of IL&#8208;6 and mTORC1 and Efficacy and Feasibility of an Integrated Approach Encompassing Cognitive Behavioral Therapy Along with Pregabalin for Management of Neuropathic Pain in Postherpetic Neuralgia&#58; A Pilot Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;K&#46; Saxena"
                            1 => "N&#46; Bhardwaj"
                            2 => "G&#46;T&#46; Chilkoti"
                            3 => "A&#46; Malik"
                            4 => "G&#46;K&#46; Thakur"
                            5 => "M&#46; Bajaj"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pain Med&#46;"
                        "fecha" => "2021"
                        "volumen" => "22"
                        "paginaInicial" => "2276"
                        "paginaFinal" => "2282"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/26662752/0000009800000002/v1_202302281436/S2666275222002934/v1_202302281436/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "89618"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigo Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/26662752/0000009800000002/v1_202302281436/S2666275222002934/v1_202302281436/pt/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222002934?idApp=UINPBA00008Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Artigo original
Níveis séricos de interleucina‐6 estão aumentados na neuralgia pós‐herpética: estudo retrospectivo de centro único
Ding Lina, Changyang Zhongb,
Corresponding author
zhongchangyang@aliyun.com

Autor para correspondência.
, Quanlong Jiangc, Aihua Huangb, Yuan Liub, Yan Zhangb
a Departamento de Cardiologia, Hangzhou Third People's Hospital, Hangzhou, China
b Departamento de Doenças Cerebrovasculares, Hangzhou Third People's Hospital, Hangzhou, China
c Hangzhou Binjiang District Changhe Street Community Health Service Center, Hangzhou, China
Read
3791
Times
was read the article
1533
Total PDF
2258
Total HTML
Share statistics
 array:23 [
  "pii" => "S2666275222002934"
  "issn" => "26662752"
  "doi" => "10.1016/j.abdp.2022.12.004"
  "estado" => "S300"
  "fechaPublicacion" => "2023-03-01"
  "aid" => "674"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "fla"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:18 [
      "pii" => "S0365059622002811"
      "issn" => "03650596"
      "doi" => "10.1016/j.abd.2022.03.007"
      "estado" => "S300"
      "fechaPublicacion" => "2023-03-01"
      "aid" => "674"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "fla"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Serum interleukin-6 levels are increased in post-herpetic neuralgia&#58; a single-center retrospective study"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "202"
            "paginaFinal" => "207"
          ]
        ]
        "contieneResumen" => array:1 [
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig0015"
            "etiqueta" => "Figure 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1772
                "Ancho" => 1680
                "Tamanyo" => 136096
              ]
            ]
            "detalles" => array:1 [
              0 => array:3 [
                "identificador" => "at0015"
                "detalle" => "Figure "
                "rol" => "short"
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Receiver operator curve of IL6 for postherpetic neuralgia&#46; The area under the curve values was 0&#46;896 &#40;95&#37; CI 0&#46;85&#8210;0&#46;95&#44; p&#8239;&#60;&#8239;0&#46;0001&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ding Lin, Changyang Zhong, Quanlong Jiang, Aihua Huang, Yuan Liu"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Ding"
                "apellidos" => "Lin"
              ]
              1 => array:2 [
                "nombre" => "Changyang"
                "apellidos" => "Zhong"
              ]
              2 => array:2 [
                "nombre" => "Quanlong"
                "apellidos" => "Jiang"
              ]
              3 => array:2 [
                "nombre" => "Aihua"
                "apellidos" => "Huang"
              ]
              4 => array:2 [
                "nombre" => "Yuan"
                "apellidos" => "Liu"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "pt" => array:9 [
          "pii" => "S2666275222002934"
          "doi" => "10.1016/j.abdp.2022.12.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "pt"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222002934?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002811?idApp=UINPBA00008Z"
      "url" => "/03650596/0000009800000002/v1_202302171515/S0365059622002811/v1_202302171515/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2666275222002880"
    "issn" => "26662752"
    "doi" => "10.1016/j.abdp.2022.11.033"
    "estado" => "S300"
    "fechaPublicacion" => "2023-03-01"
    "aid" => "669"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "pt" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
      "titulo" => "Achados da pele&#44; mucosa e unhas em pacientes pedi&#225;tricos hospitalizados com a doen&#231;a do coronav&#237;rus&#8208;2019 &#40;COVID&#8208;19&#41;"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "208"
          "paginaFinal" => "215"
        ]
      ]
      "contieneResumen" => array:1 [
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2000
              "Ancho" => 3341
              "Tamanyo" => 509952
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Alguns dos padr&#245;es de erup&#231;&#245;es cut&#226;neas no grupo de estudo&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Tun&#231; &#214;zen, Filiz Cebeci Kahraman, Sevliya &#214;cal, H&#252;sn&#252; Fahri Oval&#305;"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Tun&#231;"
              "apellidos" => "&#214;zen"
            ]
            1 => array:2 [
              "nombre" => "Filiz Cebeci"
              "apellidos" => "Kahraman"
            ]
            2 => array:2 [
              "nombre" => "Sevliya"
              "apellidos" => "&#214;cal"
            ]
            3 => array:2 [
              "nombre" => "H&#252;sn&#252; Fahri"
              "apellidos" => "Oval&#305;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0365059622002768"
        "doi" => "10.1016/j.abd.2022.03.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002768?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222002880?idApp=UINPBA00008Z"
    "url" => "/26662752/0000009800000002/v1_202302281436/S2666275222002880/v1_202302281436/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2666275222003113"
    "issn" => "26662752"
    "doi" => "10.1016/j.abdp.2022.12.022"
    "estado" => "S300"
    "fechaPublicacion" => "2023-03-01"
    "aid" => "692"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
      "titulo" => "Quantifica&#231;&#227;o dos poliomav&#237;rus humanos MCPyV e HPyV6 em les&#245;es cut&#226;neas malignas e n&#227;o malignas"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "198"
          "paginaFinal" => "201"
        ]
      ]
      "contieneResumen" => array:1 [
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marianna T&#46; Venceslau, Gabriella R&#46;M&#46; da Costa, Maria Angelica A&#46;M&#46; Guimar&#227;es, Rafael B&#46; Varella, Flavio B&#46; Luz"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Marianna T&#46;"
              "apellidos" => "Venceslau"
            ]
            1 => array:2 [
              "nombre" => "Gabriella R&#46;M&#46;"
              "apellidos" => "da Costa"
            ]
            2 => array:2 [
              "nombre" => "Maria Angelica A&#46;M&#46;"
              "apellidos" => "Guimar&#227;es"
            ]
            3 => array:2 [
              "nombre" => "Rafael B&#46;"
              "apellidos" => "Varella"
            ]
            4 => array:2 [
              "nombre" => "Flavio B&#46;"
              "apellidos" => "Luz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0365059622003130"
        "doi" => "10.1016/j.abd.2022.02.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622003130?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222003113?idApp=UINPBA00008Z"
    "url" => "/26662752/0000009800000002/v1_202302281436/S2666275222003113/v1_202302281436/pt/main.assets"
  ]
  "pt" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
    "titulo" => "N&#237;veis s&#233;ricos de interleucina&#8208;6 est&#227;o aumentados na neuralgia p&#243;s&#8208;herp&#233;tica&#58; estudo retrospectivo de centro &#250;nico"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "202"
        "paginaFinal" => "207"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ding Lin, Changyang Zhong, Quanlong Jiang, Aihua Huang, Yuan Liu, Yan Zhang"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "Ding"
            "apellidos" => "Lin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Changyang"
            "apellidos" => "Zhong"
            "email" => array:1 [
              0 => "zhongchangyang@aliyun.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Quanlong"
            "apellidos" => "Jiang"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Aihua"
            "apellidos" => "Huang"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Yuan"
            "apellidos" => "Liu"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Yan"
            "apellidos" => "Zhang"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Cardiologia&#44; Hangzhou Third People&#39;s Hospital&#44; Hangzhou&#44; China"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Doen&#231;as Cerebrovasculares&#44; Hangzhou Third People&#39;s Hospital&#44; Hangzhou&#44; China"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Hangzhou Binjiang District Changhe Street Community Health Service Center&#44; Hangzhou&#44; China"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspond&#234;ncia&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1093
            "Ancho" => 1672
            "Tamanyo" => 67362
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis s&#233;ricos de IL&#8208;6 nos grupos de NPH e volunt&#225;rios saud&#225;veis &#40;&#42;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">O v&#237;rus da varicela&#8208;z&#243;ster &#40;VZV&#41; &#233; um herpesv&#237;rus alfa humano&#46; Quando uma pessoa &#233; infectada pelo VZV pela primeira vez&#44; o que geralmente acontece na inf&#226;ncia&#44; ocorre a varicela&#46; O herpes&#8208;z&#243;ster &#40;HZ&#41; &#233; causado pela reativa&#231;&#227;o do VZV latente no nervo craniano ou g&#226;nglios da raiz dorsal na idade adulta&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a> possivelmente levando &#224; neuralgia p&#243;s&#8208;herp&#233;tica &#40;NPH&#41;&#46; Mesmo ap&#243;s a cura das les&#245;es cut&#226;neas&#44; a neuralgia cut&#226;nea local ainda persiste por meses ou anos&#44; ou at&#233; mesmo evolui para neuralgia refrat&#225;ria&#44; que ocorre frequentemente em pessoas de meia&#8208;idade e idosos e causa dor de longa dura&#231;&#227;o&#44; principalmente em mulheres idosas&#46; Al&#233;m disso&#44; a neuralgia refrat&#225;ria tamb&#233;m leva &#224; anorexia&#44; ins&#244;nia e depress&#227;o&#44; que causam s&#233;rio impacto na vida dos pacientes&#46; Estudos recentes mostraram que a NPH &#233; um tipo de dor neurop&#225;tica&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">2</span></a> e os fatores de risco da NPH incluem idade&#44; sexo&#44; sintomas precursores da erup&#231;&#227;o cut&#226;nea&#44; les&#227;o cut&#226;nea grave&#44; dor aguda grave e fatores psicossociais&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">3</span></a> A taxa de incid&#234;ncia de NPH &#233; de cerca de 2 a 4&#44;6 casos por 1&#46;000 pessoas por ano&#44; e essa taxa aumenta para 9&#44;1 casos por 1&#46;000 pessoas por ano na faixa et&#225;ria de 50 a 75 anos&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a> Estudos mostraram que a taxa geral de incid&#234;ncia de NPH na China &#233; de 6&#44;64 casos por 1&#46;000 pessoas&#46; Al&#233;m disso&#44; houve 99 epis&#243;dios recorrentes em 4&#46;313 epis&#243;dios prim&#225;rios de 2015 a 2017&#46; No entanto&#44; o n&#250;mero m&#233;dio de consultas de pacientes com doen&#231;a inicial foi significantemente menor do que o de pacientes recorrentes &#40;3&#44;6 <span class="elsevierStyleItalic">vs</span>&#46; 6&#44;7 por paciente&#41;&#44; e o tempo m&#233;dio de interna&#231;&#227;o de ataques recorrentes &#233; maior do que o do primeiro ataque&#46; Cerca de 9&#37; a 34&#37; dos pacientes desenvolver&#227;o NPH&#44; e as taxas de incid&#234;ncia e preval&#234;ncia aumentam gradualmente com a idade&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Apesar dos danos causados pela NPH&#44; o mecanismo da doen&#231;a permanece obscuro na China&#46; Atualmente&#44; biomarcadores eficazes para prever a NPH permanecem indispon&#237;veis&#44; o que dificulta a preven&#231;&#227;o da NPH e o sucesso de seu tratamento&#46; A rela&#231;&#227;o entre os n&#237;veis s&#233;ricos de citocinas e os graus de dor em pacientes com NPH foi investigada atrav&#233;s da observa&#231;&#227;o das altera&#231;&#245;es dos n&#237;veis s&#233;ricos de citocinas para descobrir os fatores imunol&#243;gicos que afetam o aparecimento da NPH&#44; estabelecendo assim as bases para a interven&#231;&#227;o cl&#237;nica precoce&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Pacientes e crit&#233;rios de elegibilidade</span><p id="par0015" class="elsevierStylePara elsevierViewall">Todos os participantes forneceram consentimento informado oral e por escrito antes de participar do estudo&#46; O desenho deste estudo est&#225; em conformidade com a Declara&#231;&#227;o de Helsinque&#44; e o estudo foi aprovado pelo Comit&#234; de &#201;tica Biom&#233;dica do Hangzhou Third People&#39;s Hospital&#46; Oitenta pacientes &#40;35 homens e 45 mulheres&#41; com NPH atendidos no hospital de abril de 2019 a outubro de 2021 foram considerados aptos para o estudo&#46; A idade dos pacientes variou de 40 a 85 anos&#44; com m&#233;dia de 68&#44;3<span class="elsevierStyleHsp" style=""></span>&#177; 10&#44;1 anos&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Crit&#233;rios de inclus&#227;o para pacientes com NPH&#58; 1&#41; A NPH no presente estudo refere&#8208;se a dor no local da erup&#231;&#227;o um m&#234;s ap&#243;s a cura do HZ&#44; de acordo com os crit&#233;rios diagn&#243;sticos de NPH&#59; 2&#41; os pacientes n&#227;o devem apresentar hist&#243;rico de doen&#231;as org&#226;nicas&#44; tais como doen&#231;as card&#237;acas&#44; pulmonares ou renais&#59; 3&#41; os pacientes n&#227;o devem apresentar nenhum d&#233;ficit na fun&#231;&#227;o cognitiva e na fala&#44; de acordo com os escores da escala Likert&#59; al&#233;m disso&#44; devem ser capazes de entender e aceitar seus escores na escala Likert&#59; 4&#41; os pacientes n&#227;o devem sofrer de outras doen&#231;as do sistema imunol&#243;gico&#44; c&#226;ncer&#44; infec&#231;&#245;es bacterianas ou apresentar outros sintomas relevantes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Crit&#233;rios de exclus&#227;o para pacientes com NPH&#58; 1&#41; pacientes com menos de 40 ou mais de 80&#59; 2&#41; pacientes com disfun&#231;&#227;o cognitiva e de linguagem ou incapazes de obter escores na escala Likert&#59; 3&#41; pacientes com c&#226;ncer ou doen&#231;as autoimunes&#59; 4&#41; uso recente de imunossupressores&#59; 5&#41; mulheres gr&#225;vidas e lactantes&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A escala Likert &#233; frequentemente utilizada em estudos cl&#237;nicos e relatos de casos de NPH&#46; A faixa da pontua&#231;&#227;o dessa escala &#233; de 0 &#40;totalmente indolor&#41; a 100 &#40;a dor mais intensa que pode ocorrer&#41;&#46; Clinicamente&#44; o limiar m&#237;nimo significante de NPH &#233; de 40 pontos&#46; Dor clinicamente significante indica que o escore da escala Likert &#233; superior a 40 pontos&#59; dor intensa indica que o escore da escala Likert &#233; maior que 70 pontos&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Os pacientes com NPH foram divididos em dois grupos de acordo com a escala Likert&#46; Pacientes com escore na escala Likert superior a 70 pontos foram definidos como NPH grave&#46; Aqueles com escore na escala Likert acima de 40 pontos foram definidos como NPH leve &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&#46; O grupo NPH foi definido pela escala Likert no dia da hospitaliza&#231;&#227;o&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Detec&#231;&#227;o de n&#237;veis s&#233;ricos de IL&#8208;6 e indicadores bioqu&#237;micos</span><p id="par0040" class="elsevierStylePara elsevierViewall">Para cada paciente&#44; 3<span class="elsevierStyleHsp" style=""></span>mL de sangue venoso foram coletados no segundo dia de hospitaliza&#231;&#227;o antes do tratamento&#46; Outros 3<span class="elsevierStyleHsp" style=""></span>mL de sangue venoso foram obtidos do paciente a partir do 14&#176; dia ap&#243;s o tratamento&#44; e todas as amostras de sangue foram colocadas em tubos com anticoagulante e enviadas ao banco de amostras do hospital para separa&#231;&#227;o e criopreserva&#231;&#227;o&#46; Os n&#237;veis s&#233;ricos de IL&#8208;6 foram medidos por ELISA sandu&#237;che de anticorpos m&#250;ltiplos&#46; O kit ELISA MCP&#8208;1&#47;IP&#8208;10&#47;rnaates&#47;fractalkine humano usado neste estudo foi adquirido da Genzyme&#44; EUA&#44; e o kit inclu&#237;a &#225;gua destilada&#44; um amostrador&#44; um oscilador e um agitador magn&#233;tico&#46; Os indicadores bioqu&#237;micos foram detectados por analisador bioqu&#237;mico autom&#225;tico no laborat&#243;rio cl&#237;nico do hospital&#44; incluindo triglic&#233;rides &#40;TG&#41;&#44; colesterol total &#40;CT&#41;&#44; fator de necrose tumoral&#8208;alfa &#40;TNF&#8208;&#945;&#41;&#44; colesterol lipoprote&#237;co de baixa densidade &#40;LDL&#8208;C&#41;&#44; e interleucina&#8208;10 &#40;IL&#8208;10&#41;&#46; As condi&#231;&#245;es dos pacientes ap&#243;s o tratamento foram avaliadas pelo escore da escala Likert&#46; A correla&#231;&#227;o entre os n&#237;veis s&#233;ricos de IL&#8208;6 na hospitaliza&#231;&#227;o e o escore da escala Likert ap&#243;s o tratamento tamb&#233;m foi analisada&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Todos os pacientes receberam doses apropriadas de gabapentina oral e 1&#46;000 ug de inje&#231;&#227;o intramuscular de mecobalamina diariamente&#46; Pacientes com dor intensa receberam adicionalmente doses apropriadas de comprimidos orais de libera&#231;&#227;o prolongada de cloridrato de oxicodona&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Coleta de dados cl&#237;nicos</span><p id="par0050" class="elsevierStylePara elsevierViewall">Hist&#243;rico m&#233;dico detalhado&#44; hist&#243;rico de medica&#231;&#227;o e o exame f&#237;sico foram realizados em todos os pacientes e volunt&#225;rios saud&#225;veis&#46; Os dados cl&#237;nicos inclu&#237;ram idade&#44; sexo&#44; hist&#243;rico de tabagismo&#44; hist&#243;rico de consumo de &#225;lcool e press&#227;o arterial&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">An&#225;lise estat&#237;stica</span><p id="par0055" class="elsevierStylePara elsevierViewall">As an&#225;lises estat&#237;sticas foram realizadas no software SPSS vers&#227;o 21&#46;0 &#40;International Business Machines&#44; Corp&#46;&#44; Armonk&#44; NY&#44; EUA&#41;&#46; As caracter&#237;sticas dos pacientes foram descritas como frequ&#234;ncias &#40;porcentagens&#41; ou m&#233;dias<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#46; Diferen&#231;as significantes entre os grupos foram avaliadas por an&#225;lise de vari&#226;ncia &#40;ANOVA&#41; unidirecional&#46; O teste de qui&#8208;quadrado foi utilizado para contagem dos dados&#46; A efici&#234;ncia diagn&#243;stica foi calculada pela curva caracter&#237;stica de opera&#231;&#227;o do receptor &#40;ROC&#41;&#59; o valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 foi considerado estatisticamente significante&#46; As figuras foram criadas com o software SPSS Statistics e GraphPad Prism 8&#46;0&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0060" class="elsevierStylePara elsevierViewall">Um total de 80 pacientes com NPH e 80 volunt&#225;rios saud&#225;veis foram inclu&#237;dos no presente estudo&#46; As caracter&#237;sticas dos pacientes e volunt&#225;rios s&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">N&#227;o houve diferen&#231;as significantes entre pacientes com NPH e volunt&#225;rios nas vari&#225;veis&#44; incluindo idade&#44; sexo&#44; n&#237;veis de TNF&#8208;&#945;&#44; CT&#44; TG&#44; IL&#8208;10 e LDL&#8208;C &#40;p<span class="elsevierStyleHsp" style=""></span>&#62; 0&#44;05&#44; respectivamente&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Houve diferen&#231;a significante nos n&#237;veis s&#233;ricos de IL&#8208;6 entre os grupos NPH leve e NPH grave&#44; e os pacientes do grupo NPH grave apresentaram n&#237;veis s&#233;ricos de IL&#8208;6 mais elevados do que os do grupo NPH leve &#40;10&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;97 <span class="elsevierStyleItalic">vs</span>&#46; 6&#44;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;25&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Pacientes com NPH grave ou leve apresentaram n&#237;veis s&#233;ricos de IL&#8208;6 mais elevados do que os volunt&#225;rios saud&#225;veis&#44; com p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Os n&#237;veis s&#233;ricos de IL&#8208;6 em pacientes com herpes&#8208;z&#243;ster foram maiores do que aqueles em volunt&#225;rios saud&#225;veis &#40;7&#44;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;15 <span class="elsevierStyleItalic">vs</span>&#46; 3&#44;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;02&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;00&#59; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">A curva ROC dos n&#237;veis de IL&#8208;6 para NPH &#233; mostrada na <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a>&#46; O valor da &#225;rea sob a curva &#40;AUC&#44; <span class="elsevierStyleItalic">area under the curve</span>&#41; foi de 0&#44;896 &#40;intervalo de confian&#231;a de 95&#37;&#58; 0&#44;85&#8208;0&#44;95&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; De acordo com a curva ROC&#44; o valor de corte dos n&#237;veis s&#233;ricos de IL&#8208;6 para NPH foi de 4&#44;95 pg&#47;mL&#44; com sensibilidade de 80&#37; e especificidade de 86&#44;2&#37;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">No grupo NPH&#44; uma dose apropriada de gabapentina foi administrada por via oral com base nas condi&#231;&#245;es do paciente&#44; e mecobalamina foi administrada atrav&#233;s de inje&#231;&#245;es intramusculares em uma dose di&#225;ria&#46; Ap&#243;s o 14&#176; dia de tratamento&#44; todos os pacientes com NPH foram avaliados pelo escore da escala Likert&#46; Os resultados s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46; Os n&#237;veis s&#233;ricos de IL&#8208;6 na hospitaliza&#231;&#227;o foram associados ao escore da escala Likert ap&#243;s o 14&#176; dia de tratamento &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discuss&#227;o</span><p id="par0085" class="elsevierStylePara elsevierViewall">A NPH &#233; um tipo de dor neurop&#225;tica refrat&#225;ria&#46; Nos &#250;ltimos anos&#44; estudos mostraram que a NPH pode causar danos ao sistema nervoso&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> A doen&#231;a pode apresentar uma variedade de sintomas sist&#234;micos&#44; incluindo fadiga cr&#244;nica&#44; anorexia&#44; perda ponderal&#44; falta de atividade e ins&#244;nia&#44; acompanhados por altera&#231;&#245;es emocionais ou psicol&#243;gicas&#44; como ansiedade&#44; depress&#227;o&#44; desaten&#231;&#227;o etc&#46;&#59; alguns pacientes apresentam tend&#234;ncias suicidas&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> Na China&#44; foi relatado que cerca de 45&#37; dos pacientes com NPH sofreram interfer&#234;ncia emocional moderada a grave&#44; 40&#37; dos pacientes com NPH sofreram interfer&#234;ncia moderada a grave em suas atividades da vida di&#225;ria&#44; mais de 40&#37; dos pacientes tiveram dist&#250;rbios do sono moderados a graves e 59&#44;68&#37; dos pacientes tinham ou frequentemente tiveram pensamentos suicidas&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> Tamb&#233;m &#233; relatado na literatura estrangeira que quanto mais intensa a dor&#44; mais grave o impacto na energia&#44; no sono e na qualidade de vida geral dos pacientes&#46; Al&#233;m disso&#44; a NPH pode ter impacto moderado a grave na vida dos membros da fam&#237;lia&#44; causando fadiga&#44; estresse&#44; ins&#244;nia e sofrimento emocional&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Foi demonstrado que v&#225;rios processos inflamat&#243;rios est&#227;o envolvidos na dor neurop&#225;tica&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> Especificamente&#44; as citocinas s&#227;o capazes de regular diversas fun&#231;&#245;es fisiol&#243;gicas celulares&#46; Elas s&#227;o polipept&#237;dios com pequenos pesos moleculares que s&#227;o sintetizados e secretados por todos os tipos de c&#233;lulas do corpo&#44; desempenhando importante papel nos processos de estresse causados por trauma&#44; dor e infec&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> Atualmente&#44; v&#225;rios tipos de citocinas s&#227;o conhecidas&#44; incluindo a interleucina &#40;IL&#41;&#44; o interferon &#40;IFN&#41;&#44; o fator estimulante de col&#244;nias &#40;CSF&#41;&#44; o fator de necrose tumoral &#40;TNF&#41;&#44; o fator de crescimento neural &#40;NGF&#41; e o fator de crescimento transformador &#40;TGF&#41;&#46; Elas est&#227;o envolvidas na regula&#231;&#227;o da homeostase no sistema imunol&#243;gico e&#44; se houver estresse excessivo&#44; rea&#231;&#245;es patol&#243;gicas ocorrer&#227;o&#46; Estudos anteriores mostraram que as citocinas podem ser categorizadas como pr&#243;&#8208;inflamat&#243;rias ou anti&#8208;inflamat&#243;rias&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a> As primeiras incluem IL&#8208;6&#44; IL&#8208;1&#44; IL&#8208;8 e TNF&#44; enquanto as &#250;ltimas incluem IL&#8208;4&#44; IL&#8208;10&#44; antagonista do receptor de IL&#8208;2 sol&#250;vel e TNF&#46; Em condi&#231;&#245;es fisiol&#243;gicas normais&#44; esses dois tipos de citocinas mant&#234;m bom equil&#237;brio com a ajuda de regula&#231;&#245;es neuroend&#243;crinas e humorais&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> Vale ressaltar que a IL&#8208;6 &#233; uma citocina multi&#8208;efetora produzida por c&#233;lulas Th2&#44; macr&#243;fagos&#8208;mon&#243;citos e c&#233;lulas endoteliais&#46; &#201; uma mol&#233;cula crucial na resposta imune&#44; resposta de fase aguda e regula&#231;&#227;o hematopoi&#233;tica&#46; Al&#233;m disso&#44; como fator de diferencia&#231;&#227;o e crescimento de c&#233;lulas B&#44; c&#233;lulas T e c&#233;lulas endoteliais&#44; a IL&#8208;6 pode ativar genes&#8208;alvo&#44; participar da imunidade humoral&#44; induzir a matura&#231;&#227;o de megacari&#243;citos e atuar no crescimento&#44; na diferencia&#231;&#227;o&#44; regenera&#231;&#227;o e degrada&#231;&#227;o de c&#233;lulas nervosas nos sistemas nervosos perif&#233;rico e central&#46; Em condi&#231;&#245;es fisiol&#243;gicas normais&#44; o conte&#250;do de IL&#8208;6 secretado por macr&#243;fagos&#44; mast&#243;citos&#44; linf&#243;citos&#44; neur&#244;nios e c&#233;lulas gliais est&#225; em n&#237;vel baixo&#44; o que facilita o desenvolvimento normal e o reparo do sistema nervoso&#44; enquanto alto n&#237;vel de IL&#8208;6 pode causar danos ao sistema nervoso&#46; Os estudiosos tamb&#233;m descobriram que o n&#237;vel de IL&#8208;6 em pacientes com NPH ou neuralgia posterior foi positivamente correlacionado com perda sensorial e perda de sensa&#231;&#227;o de frio na &#225;rea da dor&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">15&#8211;19</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Com a les&#227;o do nervo perif&#233;rico&#44; a express&#227;o de IL&#8208;6 e receptores da IL&#8208;6 na medula espinhal &#233; regulada positivamente&#46; Em experimentos com animais&#44; inje&#231;&#245;es de IL&#8208;6 em ratos normais podem inibir suas respostas &#224; estimula&#231;&#227;o t&#233;rmica e mec&#226;nica&#46; Mesmo quando as respostas &#224; dor causadas pela estimula&#231;&#227;o mec&#226;nica foram preservadas&#44; as inje&#231;&#245;es de IL&#8208;6 ainda foram capazes de inibir as respostas &#224; dor causadas pela estimula&#231;&#227;o t&#233;rmica&#46; Portanto&#44; verificou&#8208;se que a IL&#8208;6 desempenha papel importante na dor persistente resultante da les&#227;o de nervos perif&#233;ricos e centrais&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">20&#44;21</span></a> Al&#233;m disso&#44; Arruda et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">22</span></a> realizaram v&#225;rios experimentos em animais&#44; nos quais anticorpos IL&#8208;6 ou IgG alog&#234;nica foram aplicados para tratar ratos com hiperalgesia persistente devido a les&#227;o de nervo perif&#233;rico&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">No presente estudo&#44; verificou&#8208;se que o n&#237;vel s&#233;rico de IL&#8208;6 correlacionou&#8208;se positivamente com o escore da escala Likert&#44; sugerindo o papel da IL&#8208;6 na progress&#227;o patol&#243;gica da NPH&#46; Algumas citocinas&#44; como IFN&#8208;&#947;&#44; IL&#8208;6 e IL&#8208;8&#44; estavam levemente aumentadas no grupo z&#243;ster em compara&#231;&#227;o com um grupo de indiv&#237;duos saud&#225;veis normais de distribui&#231;&#227;o et&#225;ria semelhante&#59; essas diferen&#231;as apenas se aproximaram da signific&#226;ncia&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a> Foi parcialmente consistente com o presente estudo&#44; mas esse estudo confirmou ainda que a IL&#8208;6 estava intimamente relacionada &#224; NPH por meio de agrupamento estratificado&#46; No presente estudo&#44; o n&#237;vel s&#233;rico de IL&#8208;6 em pacientes com NPH grave foi significantemente mais alto do que em pacientes com NPH leve ou no grupo controle saud&#225;vel&#44; e foi maior em pacientes com NPH grave do que em pacientes com NPH leve&#44; sugerindo que pacientes com NPH e altos n&#237;veis de IL&#8208;6 eram mais propensos a desenvolver NPH grave&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">No presente estudo&#44; o n&#237;vel s&#233;rico de IL&#8208;6 mostrou diferen&#231;a estatisticamente significante entre os pacientes com NPH antes e ap&#243;s o tratamento&#46; No estudo de Saxena AK et al&#46;&#44; o tratamento da neuralgia do herpes&#8208;z&#243;ster incluiu terapia cognitivo&#8208;comportamental &#40;TCC&#41; juntamente com pregabalina&#46; O efeito de al&#237;vio da dor foi not&#225;vel&#44; e uma regula&#231;&#227;o negativa significante da express&#227;o de mRNA da IL&#8208;6 foi observada&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a> Resultados consistentes foram confirmados em popula&#231;&#245;es do Leste e do Oeste Asi&#225;ticos&#46; No entanto&#44; n&#227;o foi demonstrado que o n&#237;vel de IL&#8208;6 esteja intimamente relacionado ao progn&#243;stico da NPH&#46; O presente estudo constatou que os n&#237;veis s&#233;ricos de IL&#8208;6 em pacientes com NPH na hospitaliza&#231;&#227;o est&#227;o correlacionados com o escore na escala Likert no 14&#176; dia ap&#243;s o diagn&#243;stico&#46; &#201; sugerido que os n&#237;veis s&#233;ricos de IL&#8208;6 em pacientes com NPH na hospitaliza&#231;&#227;o possam ser fator preditivo para o progn&#243;stico de curto prazo&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A IL&#8208;6 s&#233;rica pode ser indicador diagn&#243;stico de NPH com sensibilidade de 85&#37; e especificidade de 87&#44;5&#37;&#46; A possibilidade do herpes&#8208;z&#243;ster evoluir para neuralgia do herpes&#8208;z&#243;ster pode ser considerada precocemente pelo n&#237;vel de IL&#8208;6&#46; Interven&#231;&#227;o precoce e tratamento regular para pacientes com n&#237;veis elevados de IL&#8208;6 podem ajudar a aliviar a dor e melhorar sua qualidade de vida&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclus&#245;es</span><p id="par0115" class="elsevierStylePara elsevierViewall">O n&#237;vel s&#233;rico de IL&#8208;6 est&#225; relacionado com o grau de neuralgia herp&#233;tica e pode ser um biomarcador para o diagn&#243;stico de NPH&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Suporte financeiro</span><p id="par0120" class="elsevierStylePara elsevierViewall">Zhejiang Provincial Health Science and Technology Project 2022KY977&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Contribui&#231;&#227;o dos autores</span><p id="par0125" class="elsevierStylePara elsevierViewall">Ding Lin&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o de dados</p><p id="par0130" class="elsevierStylePara elsevierViewall">Changyang Zhong&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Quanlong Jiang&#58; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Aihua Huang&#58; Participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Yuan Liu&#58; Elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; an&#225;lise estat&#237;stica&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Yan Zhang&#58; Concep&#231;&#227;o e planejamento do estudo&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflito de interesses</span><p id="par0155" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres1855375"
          "titulo" => "Resumo"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Fundamentos"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "M&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Resultados"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Limita&#231;&#245;es do estudo"
            ]
            5 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Conclus&#245;es"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1613139"
          "titulo" => "Palavras&#8208;chave"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introdu&#231;&#227;o"
        ]
        3 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "M&#233;todos"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Pacientes e crit&#233;rios de elegibilidade"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Detec&#231;&#227;o de n&#237;veis s&#233;ricos de IL&#8208;6 e indicadores bioqu&#237;micos"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Coleta de dados cl&#237;nicos"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "An&#225;lise estat&#237;stica"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Resultados"
        ]
        5 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Discuss&#227;o"
        ]
        6 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conclus&#245;es"
        ]
        7 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Suporte financeiro"
        ]
        8 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Contribui&#231;&#227;o dos autores"
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conflito de interesses"
        ]
        10 => array:1 [
          "titulo" => "Refer&#234;ncias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2022-01-23"
    "fechaAceptado" => "2022-03-07"
    "PalabrasClave" => array:1 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras&#8208;chave"
          "identificador" => "xpalclavsec1613139"
          "palabras" => array:3 [
            0 => "Herpes&#8208;z&#243;ster"
            1 => "Interleucina&#8208;6"
            2 => "Neuralgia p&#243;s&#8208;herp&#233;tica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudos t&#234;m demonstrado que a taxa de incid&#234;ncia global de herpes&#8208;z&#243;ster &#40;HZ&#41; na China &#233; de 6&#44;64 casos por 1&#46;000 pessoas&#59; apesar dos agravos causados pela neuralgia p&#243;s&#8208;herp&#233;tica &#40;NPH&#41;&#44; o mecanismo da doen&#231;a ainda n&#227;o est&#225; claro na China&#46; Atualmente&#44; biomarcadores eficazes para prever a NPH permanecem indispon&#237;veis&#44; o que dificulta a preven&#231;&#227;o da NPH e o sucesso de seu tratamento&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O objetivo do estudo foi determinar o n&#237;vel s&#233;rico de interleucina&#8208;6 &#40;IL&#8208;6&#41; na NPH&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis s&#233;ricos de IL&#8208;6 foram medidos por ELISA sandu&#237;che de anticorpos m&#250;ltiplos&#46; A escala Likert foi utilizada para representar o grau de neuralgia nos pacientes&#46; Aqueles com NPH foram divididos em grupo NPH leve e grupo NPH grave&#44; de acordo com a escala de Likert&#46; A curva ROC foi realizada para avaliar a efici&#234;ncia diagn&#243;stica da IL&#8208;6 para NPH&#46; A correla&#231;&#227;o entre o n&#237;vel de IL&#8208;6 e a escala Likert antes e ap&#243;s o tratamento com gabapentina e mecobalamina foi analisada&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis de IL&#8208;6 em pacientes com NPH mostraram resultados mais elevados em rela&#231;&#227;o aos volunt&#225;rios&#46; Os pacientes do grupo NPH grave apresentaram n&#237;veis s&#233;ricos de IL&#8208;6 mais elevados do que o grupo NPH leve&#46; O escore na escala Likert estava relacionado com os n&#237;veis s&#233;ricos de IL&#8208;6 e a frequ&#234;ncia de n&#237;veis de IL&#8208;6 acima do valor de corte &#40;4&#44;95 pg&#47;mL&#41; nos grupos NPH antes e ap&#243;s o tratamento &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A dor &#233; subjetiva&#46; Alguns estados mentais&#44; como ansiedade e depress&#227;o&#44; influenciam muito a percep&#231;&#227;o individual da dor&#44; e a toler&#226;ncia &#224; dor pode variar entre as pessoas&#46; Portanto&#44; os escores de dor podem ser afetados por diferentes fatores individuais&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis s&#233;ricos de IL&#8208;6 podem ser utilizados como indicadores bioqu&#237;micos da gravidade da NPH&#46;</p></span>"
        "secciones" => array:6 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Fundamentos"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Limita&#231;&#245;es do estudo"
          ]
          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Conclus&#245;es"
          ]
        ]
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Lin D&#44; Zhong C&#44; Jiang Q&#44; Huang A&#44; Liu Y&#44; Zhang Y&#46; Serum interleukin&#8208;6 levels are increased in post&#8208;herpetic neuralgia&#58; a single&#8208;center retrospective study&#46; An Bras Dermatol&#46; 2023&#59;98&#58;203&#8211;8&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Trabalho realizado no Hangzhou Third People&#39;s Hospital e laborat&#243;rio cl&#237;nico&#44; Hangzhou Third People&#39;s Hospital&#44; Hangzhou&#44; China&#46;</p>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1704
            "Ancho" => 1512
            "Tamanyo" => 101340
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis s&#233;ricos de IL&#8208;6 nos grupos de NPH leve&#44; NPH grave e volunt&#225;rios saud&#225;veis &#40;&#42;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1093
            "Ancho" => 1672
            "Tamanyo" => 67362
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis s&#233;ricos de IL&#8208;6 nos grupos de NPH e volunt&#225;rios saud&#225;veis &#40;&#42;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1754
            "Ancho" => 1640
            "Tamanyo" => 132609
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Curva caracter&#237;stica de opera&#231;&#227;o do receptor &#40;ROC&#41; de IL&#8208;6 para NPH&#46; O valor da &#225;rea sob a curva foi de 0&#44;896 &#40;IC95&#37;&#58; 0&#44;85&#8208;0&#44;95&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">TG&#44; triglic&#233;rides&#59; CT&#44; colesterol total&#59; LDL&#8208;C&#44; colesterol lipoproteico de baixa densidade&#59; IL&#8208;10&#44; interleucina&#8208;10&#59; TNF&#8208;&#945;&#44; fator de necrose tumoral&#8208;&#945;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;sticas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neuralgia p&#243;s&#8208;herp&#233;tica leve &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neuralgia p&#243;s&#8208;herp&#233;tica grave &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Volunt&#225;rios saud&#225;veis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Escore na escala</span><span class="elsevierStyleItalic">Likert</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#47;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de &#225;lcool</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tabagismo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hipertens&#227;o</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#47;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#47;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">CT &#40;mmoL&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;52<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;69<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">IL&#8208;10 &#40;pg&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TG &#40;mmoL&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;21<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TNF&#8208;&#945; &#40;pg&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">LDL&#8208;C &#40;mmoL&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Informa&#231;&#245;es cl&#237;nicas detalhadas de pacientes com neuralgia p&#243;s&#8208;herp&#233;tica e volunt&#225;rios saud&#225;veis&#46; &#40;M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#41;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Pacientes com escore na escala Likert superior a 70 pontos foram definidos como NPH grave&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Aqueles com escore na escala Likert acima de 40 pontos foram definidos como NPH leve&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">O valor de corte dos n&#237;veis s&#233;ricos de IL6 para NPH foi de 4&#44;95 pg&#47;mL&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Escore na Escala Likert &#40;pontos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">0&#8208;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">40&#8208;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#8805; 70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Na hospitaliza&#231;&#227;o</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Paciente &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#237;vel de IL&#8208;6 s&#233;rica &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IL&#8208;6 s&#233;rica &#8805; 4&#44;95 pg&#47;mL &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;72&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#40;92&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">14 dias ap&#243;s o tratamento</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Paciente &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#237;vel de IL&#8208;6 s&#233;rica &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IL&#8208;6 s&#233;rica &#8805; 4&#44;95 pg&#47;mL &#40;caso&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;21&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;93&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Antes e ap&#243;s 14 dias de tratamento&#44; os n&#237;veis s&#233;ricos de IL&#8208;6 em cada grupo foram correlacionados com o escore na Escala Likert</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Varicella&#8208;zoster virus&#46; The Fourteenth Fleming lecture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;J&#46; Davison"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1099/0022-1317-72-3-475"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gen Virol&#46;"
                        "fecha" => "1991"
                        "volumen" => "72"
                        "paginaInicial" => "475"
                        "paginaFinal" => "486"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1848588"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of shingles&#58; Head and Campbell&#39;s 1900 monograph"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;L&#46; Oaklander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archneur.56.10.1292"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol&#46;"
                        "fecha" => "1999"
                        "volumen" => "56"
                        "paginaInicial" => "1292"
                        "paginaFinal" => "1294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10520948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy Mayo Clinic Proceedings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Ghanavatian"
                            1 => "C&#46;S&#46; Wie"
                            2 => "R&#46;S&#46; Low"
                            3 => "N&#46; Zhang"
                            4 => "J&#46;M&#46; Montoya"
                            5 => "G&#46;S&#46; Dhaliwal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.mayocp.2018.11.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc&#46;"
                        "fecha" => "2019"
                        "volumen" => "94"
                        "paginaInicial" => "484"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30718068"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pain&#44; itch&#44; quality of life&#44; and costs after herpes zoster"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;J&#46;M&#46; van Wijck"
                            1 => "Y&#46;R&#46; Aerssens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/papr.12518"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pain Pract&#46;"
                        "fecha" => "2017"
                        "volumen" => "17"
                        "paginaInicial" => "738"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27611885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and disease burden of herpes zoster in the population aged &#8805;50 years in China&#58; data from an integrated health care network"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "X&#46; Sun"
                            1 => "Z&#46; Wei"
                            2 => "H&#46; Lin"
                            3 => "M&#46; Jit"
                            4 => "Z&#46; Li"
                            5 => "C&#46; Fu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jinf.2021.03.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect&#46;"
                        "fecha" => "2021"
                        "volumen" => "82"
                        "paginaInicial" => "253"
                        "paginaFinal" => "260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33774019"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice&#46; Postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;W&#46; Johnson"
                            1 => "A&#46;S&#46;C&#46; Rice"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMcp1403062"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2014"
                        "volumen" => "371"
                        "paginaInicial" => "1526"
                        "paginaFinal" => "1533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25317872"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of sympathetic nerve blocks in herpes zoster and postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;L&#46; Wu"
                            1 => "A&#46; Marsh"
                            2 => "R&#46;H&#46; Dworkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pain&#46;"
                        "fecha" => "2000"
                        "volumen" => "87"
                        "paginaInicial" => "121"
                        "paginaFinal" => "129"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of herpes zoster and post&#8208;herpetic neuralgia on health&#8208;related quality of life in Japanese adults aged 60 years or older&#58; results from a prospective&#44; observational cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Mizukami"
                            1 => "K&#46; Sato"
                            2 => "K&#46; Adachi"
                            3 => "S&#46; Matthews"
                            4 => "K&#46; Holl"
                            5 => "T&#46; Matsuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s40261-017-0581-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Drug Investig&#46;"
                        "fecha" => "2018"
                        "volumen" => "38"
                        "paginaInicial" => "29"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29086340"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical investigation and analysis of postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;Y&#46; Wang"
                            1 => "Bao Jia-jin"
                            2 => "Wei Xing"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chin J Pain Med&#46;"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "198"
                        "paginaFinal" => "200"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pain&#44; medication use&#44; and health&#8208;related quality of life in older persons with postherpetic neuralgia&#58; results from a population&#8208;based survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; Oster"
                            1 => "G&#46; Harding"
                            2 => "E&#46; Dukes"
                            3 => "J&#46; Edelsberg"
                            4 => "P&#46;D&#46; Cleary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpain.2005.01.359"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pain&#46;"
                        "fecha" => "2005"
                        "volumen" => "6"
                        "paginaInicial" => "356"
                        "paginaFinal" => "363"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15943957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A meta&#8208;analysis of stroke risk following herpes zoster infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46; Marra"
                            1 => "J&#46; Ruckenstein"
                            2 => "K&#46; Richardson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12879-016-2122-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Infect Dis&#46;"
                        "fecha" => "2017"
                        "volumen" => "17"
                        "paginaInicial" => "1"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28049444"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytokines and chemokines at the crossroads of neuroinflammation&#44; neurodegeneration&#44; and neuropathic pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Ramesh"
                            1 => "A&#46;G&#46; MacLean"
                            2 => "M&#46;T&#46; Philipp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2013/480739"
                      "Revista" => array:5 [
                        "tituloSerie" => "Mediators Inflamm&#46;"
                        "fecha" => "2013"
                        "volumen" => "2013"
                        "paginaInicial" => "480739"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23997430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of cytokines in acute neurodegeneration in the CNS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;J&#46; Rothwell"
                            1 => "J&#46;K&#46; Relton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0149-7634(05)80152-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosci Biobehav Rev&#46;"
                        "fecha" => "1993"
                        "volumen" => "17"
                        "paginaInicial" => "217"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8515904"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Study on the related factors of post&#8208;herpetic neuralgia in hospitalized patients with herpes zoster in Sichuan Hospital of Traditional Chinese Medicine based on big data analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Li"
                            1 => "J&#46; Wang"
                            2 => "H&#46; Xie"
                            3 => "P&#46; Hao"
                            4 => "C&#46; Qing"
                            5 => "Y&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.14410"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2020"
                        "volumen" => "33"
                        "paginaInicial" => "e14410"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33052606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL&#8208;6 contributes to corneal nerve degeneration after herpes simplex virus type I infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;J&#46; Chucair-Elliott"
                            1 => "J&#46; Jinkins"
                            2 => "M&#46;M&#46; Carr"
                            3 => "D&#46;J&#46;J&#46; Carr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajpath.2016.06.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol&#46;"
                        "fecha" => "2016"
                        "volumen" => "186"
                        "paginaInicial" => "2665"
                        "paginaFinal" => "2678"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27497323"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral Chinese herbal medicine for post&#8208;herpetic neuralgia&#58; A systematic review and meta&#8208;analysis of randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Liang"
                            1 => "M&#46;E&#46; Coyle"
                            2 => "K&#46; Wang"
                            3 => "A&#46;L&#46; Zhang"
                            4 => "X&#46; Guo"
                            5 => "H&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "European Journal of Integrative Medicine&#46;"
                        "fecha" => "2017"
                        "volumen" => "10"
                        "paginaInicial" => "46"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interventional treatments for postherpetic neuralgia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;S&#46; Lin"
                            1 => "Y&#46;C&#46; Lin"
                            2 => "H&#46;C&#46; Lao"
                            3 => "C&#46;C&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pain Physician&#46;"
                        "fecha" => "2019"
                        "volumen" => "22"
                        "paginaInicial" => "209"
                        "paginaFinal" => "228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31151330"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Up&#8208;date on clinical management of postherpetic neuralgia and mechanism&#8208;based treatment&#58; new options in therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Forstenpointner"
                            1 => "A&#46;S&#46;C&#46; Rice"
                            2 => "N&#46;B&#46; Finnerup"
                            3 => "R&#46; Baron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect Dis&#46;"
                        "fecha" => "2018"
                        "volumen" => "218"
                        "numero" => "suppl&#95;2"
                        "paginaInicial" => "S120"
                        "paginaFinal" => "S126"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Relationship between the Level of Serum IL&#8208;6 and the Injury of Never System in Patients with Postherpetic Neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Chen"
                            1 => "P&#46; Xie"
                            2 => "D&#46; Zou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Chin J Neuroimmunol Neurol&#46;"
                        "fecha" => "2005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of galanin on neuropathic pain in streptozotocin&#8208;induced diabetic rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Xu"
                            1 => "Z&#46; Liu"
                            2 => "H&#46; Liu"
                            3 => "X&#46; Yang"
                            4 => "Z&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejphar.2012.01.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Pharmacol&#46;"
                        "fecha" => "2012"
                        "volumen" => "680"
                        "paginaInicial" => "28"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22306246"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of extracts from rabbit skin inflamed by vaccinia virus in the management of postherpetic neuralgia and on serum interleukin&#8208;6 level in aged patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "X&#46;M&#46; Yang"
                            1 => "R&#46;G&#46; He"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nan Fang Yi Ke Da Xue Xue Bao&#46;"
                        "fecha" => "2007"
                        "volumen" => "27"
                        "paginaInicial" => "1941"
                        "paginaFinal" => "1943"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18159027"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intrathecal anti&#8208;IL&#8208;6 antibody and IgG attenuates peripheral nerve injury&#8208;induced mechanical allodynia in the rat&#58; possible immune modulation in neuropathic pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;L&#46; Arruda"
                            1 => "S&#46; Sweitzer"
                            2 => "M&#46;D&#46; Rutkowski"
                            3 => "J&#46;A&#46; DeLeo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Brain Res&#46;"
                        "fecha" => "2000"
                        "volumen" => "879"
                        "paginaInicial" => "216"
                        "paginaFinal" => "225"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Local immune responses and systemic cytokine responses in zoster&#58; relationship to the development of postherpetic neuralgia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Zak-Prelich"
                            1 => "R&#46;C&#46; McKenzie"
                            2 => "A&#46; Sysa-Jedrzejowska"
                            3 => "M&#46; Norval"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-2249.2003.02061.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol&#46;"
                        "fecha" => "2003"
                        "volumen" => "131"
                        "paginaInicial" => "318"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12562395"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modulation of mRNA Expression of IL&#8208;6 and mTORC1 and Efficacy and Feasibility of an Integrated Approach Encompassing Cognitive Behavioral Therapy Along with Pregabalin for Management of Neuropathic Pain in Postherpetic Neuralgia&#58; A Pilot Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;K&#46; Saxena"
                            1 => "N&#46; Bhardwaj"
                            2 => "G&#46;T&#46; Chilkoti"
                            3 => "A&#46; Malik"
                            4 => "G&#46;K&#46; Thakur"
                            5 => "M&#46; Bajaj"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pain Med&#46;"
                        "fecha" => "2021"
                        "volumen" => "22"
                        "paginaInicial" => "2276"
                        "paginaFinal" => "2282"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/26662752/0000009800000002/v1_202302281436/S2666275222002934/v1_202302281436/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "89618"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigo Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/26662752/0000009800000002/v1_202302281436/S2666275222002934/v1_202302281436/pt/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222002934?idApp=UINPBA00008Z"
]
Article information
ISSN: 26662752
Original language: Portuguese
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 19 5 24
2024 October 145 62 207
2024 September 145 87 232
2024 August 177 125 302
2024 July 153 97 250
2024 June 136 74 210
2024 May 94 63 157
2024 April 107 96 203
2024 March 95 81 176
2024 February 105 89 194
2024 January 86 63 149
2023 December 88 55 143
2023 November 102 86 188
2023 October 83 80 163
2023 September 91 83 174
2023 August 93 39 132
2023 July 103 51 154
2023 June 99 55 154
2023 May 91 28 119
2023 April 62 43 105
2023 March 83 65 148
2023 February 33 34 67
2023 January 37 66 103
2022 December 31 6 37
Show all

Follow this link to access the full text of the article

Idiomas
Anais Brasileiros de Dermatologia
en pt
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.