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1&#8211;4</a>&#41;&#46; A distribui&#231;&#227;o das les&#245;es seguia as linhas de Blaschko&#46; A histopatologia mostrou m&#250;ltiplos pequenos t&#250;bulos&#44; cistos e ninhos epiteliais&#44; alguns deles morfologicamente semelhantes a uma v&#237;rgula ou girino&#44; na derme superficial &#40;<a class="elsevierStyleCrossRef" href="#fig0025">fig&#46; 5</a>&#41;&#46; Foi feito o diagn&#243;stico de siringoma linear espor&#225;dico&#46; Por se tratar de doen&#231;a benigna sem potencial maligno&#44; o paciente est&#225; em acompanhamento regular sem nenhum tratamento&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discuss&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">O siringoma &#233; neoplasia benigna que deriva dos ductos das gl&#226;ndulas sudor&#237;paras &#233;crinas&#46; A manifesta&#231;&#227;o cl&#237;nica t&#237;pica s&#227;o p&#225;pulas de cor da pele ou amareladas&#44; &#250;nicas ou m&#250;ltiplas&#44; na p&#225;lpebra inferior&#44; medindo de 1 a 3<span class="elsevierStyleHsp" style=""></span>mm&#46; Friedman e Butler classificaram o siringoma em quatro variantes cl&#237;nicas&#58; generalizada&#44; localizada&#44; familiar e associada &#224; s&#237;ndrome de Down&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> O diagn&#243;stico diferencial do siringoma com base em uma variedade de manifesta&#231;&#245;es cl&#237;nicas inclui milia&#44; xantoma&#44; hidrocistoma&#44; tricoepitelioma&#44; verrugas planas&#44; principalmente nas p&#225;lpebras&#59; outras possibilidades incluem mastocitose cut&#226;nea&#44; fibrofoliculomas&#44; cistos de pelos velos&#44; angiofibromas e papulose fibroel&#225;stica&#44; l&#237;quen plano&#44; esteatocistoma m&#250;ltiplo&#44; cistos de pelos velos eruptivos&#44; granuloma anular disseminado&#44; s&#237;filis secund&#225;ria entre outras&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;3</span></a> O diagn&#243;stico pode ser confirmado por achados histopatol&#243;gicos t&#237;picos&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Embora siringoma seja neoplasia comum&#44; sua patog&#234;nese permanece obscura&#44; e alguns pesquisadores sugeriram que possam ser causados por fatores hormonais&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> O arranjo linear ao longo das linhas de Blaschko &#233; incomum e indica uma associa&#231;&#227;o gen&#233;tica na patog&#234;nese&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Entretanto&#44; nenhuma anormalidade cong&#234;nita foi encontrada no presente caso&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Como &#233; de conhecimento geral&#44; o siringoma raramente apresenta distribui&#231;&#227;o unilateral ou linear&#46; Houve apenas quatro relatos de siringoma linear unilateral&#44; todos envolvendo o tronco e o membro superior&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6&#8211;9</span></a> Sabe&#8208;se&#44; com base em casos relatados anteriormente&#44; que o siringoma linear geralmente se apresenta clinicamente muito semelhante ao siringoma comum&#46; No entanto&#44; no presente caso&#44; o tamanho da maioria das les&#245;es cut&#226;neas era maior que o tamanho usual e a cor era diferente&#44; o que alerta os dermatologistas para a necessidade de considerar o siringoma no diagn&#243;stico diferencial de les&#245;es cut&#226;neas em placas ou p&#225;pulas lineares unilaterais&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Suporte financeiro</span><p id="par0025" class="elsevierStylePara elsevierViewall">Este trabalho recebeu suporte financeiro de Medical Science and Technology Research Projects na Prov&#237;ncia de Guangdong &#40;A2021365&#41; e Science and Technology Plan Projects de Zhuhai &#40;ZH2202200003HJL&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Contribui&#231;&#227;o dos autores</span><p id="par0030" class="elsevierStylePara elsevierViewall">Danyi Huang &#8208; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#46; Yanqing Chen &#8208; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46; Jianjian Li &#8208; ajudou na obten&#231;&#227;o de dados&#46; Han Ma &#8208; concep&#231;&#227;o e planejamento do estudo&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflito de interesses</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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Cartas ‐ Caso clínico
Siringoma linear unilateral no tórax e braço direito
Danyi Huang1, Yanqing Chen1, Jianjian Li, Han Ma
Corresponding author
drmahan@sina.com

Autor para correspondência.
Departamento de Dermatologia, the Fifth Affiliated Hospital of Sun Yat‐sen University, Zhuhai, Guangdong, China
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1&#8211;4</a>&#41;&#46; A distribui&#231;&#227;o das les&#245;es seguia as linhas de Blaschko&#46; A histopatologia mostrou m&#250;ltiplos pequenos t&#250;bulos&#44; cistos e ninhos epiteliais&#44; alguns deles morfologicamente semelhantes a uma v&#237;rgula ou girino&#44; na derme superficial &#40;<a class="elsevierStyleCrossRef" href="#fig0025">fig&#46; 5</a>&#41;&#46; Foi feito o diagn&#243;stico de siringoma linear espor&#225;dico&#46; Por se tratar de doen&#231;a benigna sem potencial maligno&#44; o paciente est&#225; em acompanhamento regular sem nenhum tratamento&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discuss&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">O siringoma &#233; neoplasia benigna que deriva dos ductos das gl&#226;ndulas sudor&#237;paras &#233;crinas&#46; A manifesta&#231;&#227;o cl&#237;nica t&#237;pica s&#227;o p&#225;pulas de cor da pele ou amareladas&#44; &#250;nicas ou m&#250;ltiplas&#44; na p&#225;lpebra inferior&#44; medindo de 1 a 3<span class="elsevierStyleHsp" style=""></span>mm&#46; Friedman e Butler classificaram o siringoma em quatro variantes cl&#237;nicas&#58; generalizada&#44; localizada&#44; familiar e associada &#224; s&#237;ndrome de Down&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> O diagn&#243;stico diferencial do siringoma com base em uma variedade de manifesta&#231;&#245;es cl&#237;nicas inclui milia&#44; xantoma&#44; hidrocistoma&#44; tricoepitelioma&#44; verrugas planas&#44; principalmente nas p&#225;lpebras&#59; outras possibilidades incluem mastocitose cut&#226;nea&#44; fibrofoliculomas&#44; cistos de pelos velos&#44; angiofibromas e papulose fibroel&#225;stica&#44; l&#237;quen plano&#44; esteatocistoma m&#250;ltiplo&#44; cistos de pelos velos eruptivos&#44; granuloma anular disseminado&#44; s&#237;filis secund&#225;ria entre outras&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;3</span></a> O diagn&#243;stico pode ser confirmado por achados histopatol&#243;gicos t&#237;picos&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Embora siringoma seja neoplasia comum&#44; sua patog&#234;nese permanece obscura&#44; e alguns pesquisadores sugeriram que possam ser causados por fatores hormonais&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> O arranjo linear ao longo das linhas de Blaschko &#233; incomum e indica uma associa&#231;&#227;o gen&#233;tica na patog&#234;nese&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Entretanto&#44; nenhuma anormalidade cong&#234;nita foi encontrada no presente caso&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Como &#233; 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e Science and Technology Plan Projects de Zhuhai &#40;ZH2202200003HJL&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Contribui&#231;&#227;o dos autores</span><p id="par0030" class="elsevierStylePara elsevierViewall">Danyi Huang &#8208; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#46; Yanqing Chen &#8208; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46; Jianjian Li &#8208; ajudou na obten&#231;&#227;o de dados&#46; Han Ma &#8208; concep&#231;&#227;o e planejamento do estudo&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflito de interesses</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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Article information
ISSN: 26662752
Original language: Portuguese
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