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10<span class="elsevierStyleHsp" style=""></span>Hz com dura&#231;&#227;o de pulso de 100<span class="elsevierStyleHsp" style=""></span>&#956;sn &#40;Fotona&#44; XS&#44; Dynamis&#41;&#46; Em virtude da necessidade de sedoanalgesia para as les&#245;es remanescentes&#44; foi oferecida a combina&#231;&#227;o de laser de &#233;rbio fracionado&#58; YAG e imiquimode t&#243;pico&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Os ciclos de tratamento predeterminados de quatro semanas foram repetidos por seis meses como aplica&#231;&#245;es mensais de laser fracionado ablativo &#40;AFL&#44; do ingl&#234;s <span class="elsevierStyleItalic">ablative fractional laser</span>&#41; imediatamente seguidas de creme de imiquimode aplicado cinco dias consecutivos por semana nas primeiras duas semanas&#46; Isso foi seguido por um per&#237;odo sem tratamento de duas semanas&#46; Ocorreu irrita&#231;&#227;o grave&#44; que diminuiu durante os per&#237;odos sem tratamento&#46; No controle de seis meses&#44; o escore autorreferido pela paciente mudou de dez para 0 para a parte tratada com laser de campo completo e dez para dois para as partes tratadas com uma combina&#231;&#227;o de AFL e imiquimode &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; A paciente est&#225; em seguimento h&#225; 1&#44;5 ano sem recorr&#234;ncia &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#44; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>B&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A SBS &#233; uma doen&#231;a autoss&#244;mica dominante caracterizada por neoplasias cut&#226;neas benignas de crescimento progressivo&#44; estigmatizantes&#44; localizadas na pele da face e no couro cabeludo&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A excis&#227;o cir&#250;rgica e modalidades destrutivas alternativas foram relatadas para neoplasias de pele na SBS&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> O objetivo ideal das interven&#231;&#245;es &#233; remover as les&#245;es sem deixar cicatrizes e sem despigmenta&#231;&#227;o&#44; mas ainda de forma suficientemente eficaz para evitar recorr&#234;ncias&#46; Recentemente&#44; tratamentos t&#243;picos com sirolimus e imiquimode foram sugeridos como abordagens n&#227;o invasivas&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">A primeira observa&#231;&#227;o sobre a efic&#225;cia do imiquimode foi relatada em um caso com tricoepiteliomas m&#250;ltiplos faciais &#40;TMF&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> A tretino&#237;na t&#243;pica foi introduzida no sexto m&#234;s para melhorar a penetra&#231;&#227;o do imiquimode&#46; Essa combina&#231;&#227;o foi mantida at&#233; o terceiro ano&#46; Estudo retrospectivo mostrou resposta parcial ap&#243;s 32 semanas de tratamento com imiquimode em dois pacientes com SBS&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Essas dura&#231;&#245;es de tratamento s&#227;o significativamente maiores quando comparadas &#224;s indica&#231;&#245;es aprovadas de imiquimode &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; 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          "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Imagem de perto das les&#245;es de tricoepitelioma localizadas no dorso do nariz&#46; &#40;B&#41; O mesmo local no &#250;ltimo seguimento&#46;</p>"
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          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">TMF&#44; tricoepitelioma m&#250;ltiplo facial&#59; SBS&#44; s&#237;ndrome de Brooke&#8208;Spiegler&#59; IMI&#44; imiquimode&#59; TFD&#44; terapia fotodin&#226;mica&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autor&#44; ano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tipo&#47; quantidade de pacientes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tratamento&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dura&#231;&#227;o semanas &#40;sem&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Urquhart JL&#44; 2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TMF&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IMI&#43;Tretino&#237;na&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">156&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#37; resolu&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alessi SS&#44; 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SBS&#47;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resposta parcial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LoPiccolo MC&#44; 2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SBS&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 grupos IMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grau da doen&#231;a declarado pelo paciente &#40;em compara&#231;&#227;o com a linha basal&#41; 10&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Er&#58; laser YAG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Er&#58; laser YAG &#43; IMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Er&#58; laser YAG &#43; TFD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tu JH et al&#46;&#44; 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TMF&#47;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Laser</span> CO<span class="elsevierStyleInf">2</span> &#43; Sirolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recrescimento limitado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sirolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Progress&#227;o limitada da doen&#231;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dados da literatura sobre as op&#231;&#245;es de tratamento t&#243;pico da SBS&#47;TMF</p>"
        ]
      ]
    ]
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      "titulo" => "Refer&#234;ncias"
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        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparing ablative fractionated resurfacing&#44; photodynamic therapy&#44; and topical imiquimod in the treatment of trichoblastomas of Brooke&#8208;Spiegler Syndrome&#58; a case study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; Lopiccolo"
                            1 => "R&#46;J&#46; Sage"
                            2 => "D&#46;J&#46; Kouba"
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                    0 => array:2 [
                      "doi" => "10.1111/j.1524-4725.2011.01907.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "2011"
                        "volumen" => "37"
                        "paginaInicial" => "1047"
                        "paginaFinal" => "1050"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21388481"
                            "web" => "Medline"
                          ]
                        ]
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                ]
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            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of cutaneous tumors with topical 5&#37; imiquimod cream"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;S&#46; Alessi"
                            1 => "J&#46;A&#46; Sanches"
                            2 => "W&#46;R&#46; Oliveira"
                            3 => "M&#46;C&#46; Messina"
                            4 => "E&#46;R&#46; Pimentel"
                            5 => "C&#46; Festa Neto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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Carta ‐ Caso clínico
Aplicação de imiquimode associada a laser na síndrome de Brooke‐Spiegler
Aysenur Botsali
Corresponding author
abotsali@hotmail.com

Autor para correspondência.
, Ercan Caliskan
Departamento de Dermatologia, Gulhane Training and Research Hospital, University of Health Sciences, Ancara, Turquia
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Este caso descreve uma paciente de 34 anos com s&#237;ndrome de Brooke&#8208;Spiegler &#40;SBS&#41;&#46; Ao exame dermatol&#243;gico foram detectadas p&#225;pulas normocr&#244;micas confluentes&#44; compat&#237;veis com tricoepiteliomas &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>A&#44; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>A&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Inicialmente&#44; as les&#245;es exuberantes na pele do sulco nasolabial esquerdo foram submetidas &#224; abla&#231;&#227;o com laser de &#233;rbio de campo completo&#58;YAG aplicado na configura&#231;&#227;o com tamanho de ponto de 3<span class="elsevierStyleHsp" style=""></span>mm&#44; 6<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; 10<span class="elsevierStyleHsp" style=""></span>Hz com dura&#231;&#227;o de pulso de 100<span class="elsevierStyleHsp" style=""></span>&#956;sn &#40;Fotona&#44; XS&#44; Dynamis&#41;&#46; Em virtude da necessidade de sedoanalgesia para as les&#245;es remanescentes&#44; foi oferecida a combina&#231;&#227;o de laser de &#233;rbio fracionado&#58; YAG e imiquimode t&#243;pico&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Os ciclos de tratamento predeterminados de quatro semanas foram repetidos por seis meses como aplica&#231;&#245;es mensais de laser fracionado ablativo &#40;AFL&#44; do ingl&#234;s <span class="elsevierStyleItalic">ablative fractional laser</span>&#41; imediatamente seguidas de creme de imiquimode aplicado cinco dias consecutivos por semana nas primeiras duas semanas&#46; Isso foi seguido por um per&#237;odo sem tratamento de duas semanas&#46; Ocorreu irrita&#231;&#227;o grave&#44; que diminuiu durante os per&#237;odos sem tratamento&#46; No controle de seis meses&#44; o escore autorreferido pela paciente mudou de dez para 0 para a parte tratada com laser de campo completo e dez para dois para as partes tratadas com uma combina&#231;&#227;o de AFL e imiquimode &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; A paciente est&#225; em seguimento h&#225; 1&#44;5 ano sem recorr&#234;ncia &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#44; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>B&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A SBS &#233; uma doen&#231;a autoss&#244;mica dominante caracterizada por neoplasias cut&#226;neas benignas de crescimento progressivo&#44; estigmatizantes&#44; localizadas na pele da face e no couro cabeludo&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A excis&#227;o cir&#250;rgica e modalidades destrutivas alternativas foram relatadas para neoplasias de pele na SBS&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> O objetivo ideal das interven&#231;&#245;es &#233; remover as les&#245;es sem deixar cicatrizes e sem despigmenta&#231;&#227;o&#44; mas ainda de forma suficientemente eficaz para evitar recorr&#234;ncias&#46; Recentemente&#44; tratamentos t&#243;picos com sirolimus e imiquimode foram sugeridos como abordagens n&#227;o invasivas&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">A primeira observa&#231;&#227;o sobre a efic&#225;cia do imiquimode foi relatada em um caso com tricoepiteliomas m&#250;ltiplos faciais &#40;TMF&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> A tretino&#237;na t&#243;pica foi introduzida no sexto m&#234;s para melhorar a penetra&#231;&#227;o do imiquimode&#46; Essa combina&#231;&#227;o foi mantida at&#233; o terceiro ano&#46; Estudo retrospectivo mostrou resposta parcial ap&#243;s 32 semanas de tratamento com imiquimode em dois pacientes com SBS&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Essas dura&#231;&#245;es de tratamento s&#227;o significativamente maiores quando comparadas &#224;s indica&#231;&#245;es aprovadas de imiquimode &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; Em um estudo de caso de sujeito &#250;nico&#44; a efic&#225;cia de v&#225;rios tratamentos foi avaliada&#46; Dois locais receberam imiquimode ou a combina&#231;&#227;o de AFL e imiquimode&#46; No terceiro m&#234;s&#44; o imiquimode t&#243;pico n&#227;o foi eficaz&#46; O resultado do tratamento com AFL e imiquimode tamb&#233;m foi semelhante ao AFL isolado&#46; Diferen&#231;a importante em rela&#231;&#227;o ao presente estudo de combina&#231;&#227;o &#233; que o imiquimode n&#227;o foi aplicado imediatamente&#44; mas dois dias ap&#243;s o AFL&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> &#201; sabido que o AFL aumenta o fluxo de imiquimode de 46 a 127 vezes em m&#250;ltiplas passagens&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> A aplica&#231;&#227;o imediata do agente t&#243;pico &#233; fundamental para o sucesso do tratamento com aplica&#231;&#227;o associada ao laser &#40;LAD&#44; do ingl&#234;s <span class="elsevierStyleItalic">laser assisted delivery</span>&#41;&#44; o que pode explicar as discrep&#226;ncias dos resultados do tratamento&#46; Uma limita&#231;&#227;o da observa&#231;&#227;o atual &#233; que o AFL isolado pode fornecer resultados semelhantes&#44; que n&#227;o podem ser comparados &#224; terapia combinada definida para este caso&#46; Entretanto&#44; deve&#8208;se enfatizar que a aus&#234;ncia de recorr&#234;ncia no seguimento de longo prazo &#233; extremamente rara para a SBS e os resultados detectados s&#227;o not&#225;veis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Como o imiquimode requer dura&#231;&#245;es de tratamento prolongadas para tricoepiteliomas&#44; o LAD pode ajudar a diminuir sua dura&#231;&#227;o&#46; Outra considera&#231;&#227;o importante sobre esse regime de tratamento &#233; a aus&#234;ncia de recorr&#234;ncia no seguimento de longo prazo&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0050" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0055" class="elsevierStylePara elsevierViewall">Aysenur Botsali&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Ercan Caliskan&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0065" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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    "fechaRecibido" => "2020-11-10"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Botsali A&#44; Caliskan E&#46; Laser&#8208;assisted delivery of imiquimod in Brooke&#8208;Spiegler syndrome&#46; An Bras Dermatol&#46; 2022&#59;97&#58;541&#8211;3&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Trabalho realizado no Departamento de Dermatologia&#44; University of Health Sciences&#44; Gulhane Training and Research Hospital&#44; Ancara&#44; Turquia&#46;</p>"
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          "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Na hospitaliza&#231;&#227;o&#44; foram detectadas m&#250;ltiplas p&#225;pulas normocr&#244;micas confluentes no dorso nasal&#44; sulcos alares bilaterais e regi&#245;es nasolabiais&#46; &#40;B&#41; No &#250;ltimo controle&#44; a pele do sulco nasolabial esquerdo apresentava discreta hipopigmenta&#231;&#227;o&#46; Regress&#227;o acentuada&#44; com escore de 80&#37; da paciente&#44; foi observada nas partes restantes que receberam a aplica&#231;&#227;o de imiquimode associada a <span class="elsevierStyleItalic">laser</span>&#46;</p>"
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          "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Imagem de perto das les&#245;es de tricoepitelioma localizadas no dorso do nariz&#46; &#40;B&#41; O mesmo local no &#250;ltimo seguimento&#46;</p>"
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          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">TMF&#44; tricoepitelioma m&#250;ltiplo facial&#59; SBS&#44; s&#237;ndrome de Brooke&#8208;Spiegler&#59; IMI&#44; imiquimode&#59; TFD&#44; terapia fotodin&#226;mica&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autor&#44; ano&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tipo&#47; quantidade de pacientes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tratamento&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dura&#231;&#227;o semanas &#40;sem&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Urquhart JL&#44; 2005&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">TMF&#47;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">IMI&#43;Tretino&#237;na&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">156&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">80&#37; resolu&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Alessi SS&#44; 2009&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">SBS&#47;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">IMI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Resposta parcial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">LoPiccolo MC&#44; 2011&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">SBS&#47;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 grupos IMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Grau da doen&#231;a declarado pelo paciente &#40;em compara&#231;&#227;o com a linha basal&#41; 10&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">TFD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Er&#58; laser YAG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Er&#58; laser YAG &#43; IMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Er&#58; laser YAG &#43; TFD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tu JH et al&#46;&#44; 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TMF&#47;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Laser</span> CO<span class="elsevierStyleInf">2</span> &#43; Sirolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recrescimento limitado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sirolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Progress&#227;o limitada da doen&#231;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dados da literatura sobre as op&#231;&#245;es de tratamento t&#243;pico da SBS&#47;TMF</p>"
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                      "titulo" => "Comparing ablative fractionated resurfacing&#44; photodynamic therapy&#44; and topical imiquimod in the treatment of trichoblastomas of Brooke&#8208;Spiegler Syndrome&#58; a case study"
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                        0 => array:2 [
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                        "fecha" => "2011"
                        "volumen" => "37"
                        "paginaInicial" => "1047"
                        "paginaFinal" => "1050"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21388481"
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              "identificador" => "bib0035"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Treatment of cutaneous tumors with topical 5&#37; imiquimod cream"
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                          "autores" => array:6 [
                            0 => "S&#46;S&#46; Alessi"
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                    ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinics &#40;Sao Paulo&#41;&#46;"
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                        "paginaInicial" => "961"
                        "paginaFinal" => "966"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Use of topical sirolimus in the management of multiple familial trichoepitheliomas"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:2 [
                            0 => "J&#46;H&#46; Tu"
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                  "host" => array:1 [
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                      "Revista" => array:3 [
                        "tituloSerie" => "Dermatol Ther&#46;"
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                        "paginaInicial" => "30"
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                    ]
                  ]
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                    0 => array:2 [
                      "titulo" => "Treatment of multiple trichoepitheliomas with topical imiquimod and tretinoin"
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                    0 => array:2 [
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                            3 => "H&#46;H&#46; Yang"
                            4 => "C&#46;Y&#46; Yuan"
                            5 => "J&#46;Y&#46; Fang"
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Article information
ISSN: 26662752
Original language: Portuguese
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Anais Brasileiros de Dermatologia
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