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1 e 2</a>&#41;&#46; O exame histopatol&#243;gico de bi&#243;psia de les&#227;o axilar evidenciou epiderme com espongiose discreta&#44; infiltrado d&#233;rmico&#44; linfo&#8208;histiocit&#225;rio&#44; perivascular moderado e vasodilata&#231;&#227;o&#46; Aus&#234;ncia de queratin&#243;citos necr&#243;ticos e de derrame pigmenta afastaram eritema pigmentar fixo &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Portanto&#44; os dados da hist&#243;ria cl&#237;nica&#44; dermatol&#243;gicos e histol&#243;gicos&#44; permitiram o diagn&#243;stico de SDRIFE associada ao paracetamol&#46; As les&#245;es desapareceram em poucas semanas ap&#243;s suspens&#227;o do f&#225;rmaco e uso de corticoide t&#243;pico&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Em&#160;2011&#44; 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o quadro sugere rea&#231;&#227;o de hipersensibilidade tardia mediada por c&#233;lulas&#160;T&#46; A maior densidade de gl&#226;ndulas sudor&#237;paras &#233;crinas nas regi&#245;es de dobras explicaria sua manifesta&#231;&#227;o restrita ou predominante &#224;s localiza&#231;&#245;es intertriginosas&#44; onde a excre&#231;&#227;o do f&#225;rmaco sensibilizante precipitaria a dermatose&#46; O tratamento implica na suspei&#231;&#227;o e interrup&#231;&#227;o dos f&#225;rmacos em uso&#46; Os corticoides de uso t&#243;pico ou sist&#234;mico podem acelerar a resolu&#231;&#227;o&#46; Relatos de casos e identifica&#231;&#227;o do f&#225;rmaco desencadeante s&#227;o &#250;teis do ponto de vista did&#225;tico e epidemiol&#243;gico&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0030" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0035" class="elsevierStylePara elsevierViewall">Joana Alexandria Ferreira Dias&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Luana Moraes Campos&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Juliano Vilaverde Schmitt&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">S&#237;lvio Alencar Marques&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0055" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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Carta ‐ Caso clínico
Exantema intertriginoso e flexural simétrico relacionado ao uso de paracetamol
Joana Alexandria Ferreira Dias, Luana Moraes Campos, Juliano Vilaverde Schmitt, Sílvio Alencar Marques
Corresponding author
silvio.marques@unesp.br

Autor para correspondência.
Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brasil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Em 1984&#44; Andersen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> relataram tr&#234;s pacientes que desenvolveram les&#245;es eritematosas na regi&#227;o gl&#250;tea&#44; face interna das coxas e axilas&#44; sem sintomatologia geral associada e expostos sistemicamente a al&#233;rgenos aos quais apresentavam pr&#233;via sensibiliza&#231;&#227;o de contato&#46; Por analogia das les&#245;es ao aspecto morfol&#243;gico gl&#250;teo dos babu&#237;nos &#40;<span class="elsevierStyleItalic">Papio papio</span>&#41;&#44; sugeriram a denomina&#231;&#227;o de s&#237;ndrome de baboon &#40;SB&#41; a esses casos&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Hausermann et al&#46;&#44; em&#160;2004&#44; propuseram a denomina&#231;&#227;o <span class="elsevierStyleItalic">symetrical drug&#8208;related intertriginous and flexural exanthema</span> &#40;SDRIFE&#41; para casos de sensibiliza&#231;&#227;o sist&#234;mica a f&#225;rmacos&#44; sem exposi&#231;&#227;o t&#243;pica&#44; clinicamente id&#234;nticas &#224; SB&#44; e ressaltaram a aus&#234;ncia de sinais e sintomas sist&#234;micos associados&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Relatamos paciente do sexo masculino&#44; 56&#160;anos de idade&#44; com les&#245;es na regi&#227;o inguinal e axilar&#44; pouco pruriginosas e n&#227;o associadas a outros sintomas sist&#234;micos&#46; Referia uso exclusivo de paracetamol h&#225; dois dias e quadro id&#234;ntico ao atual em exposi&#231;&#245;es pr&#233;vias&#46; Ao exame&#44; observaram&#8208;se les&#245;es eritemato&#8208;vinhosas&#44; bem delimitadas&#44; sem sinais de escoria&#231;&#227;o&#44; localiza&#231;&#227;o bilateral e sim&#233;trica nas regi&#245;es axilares&#44; inguinocrurais&#44; gl&#250;tea&#44; face lateral das coxas incluindo regi&#227;o popl&#237;tea &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1 e 2</a>&#41;&#46; O exame histopatol&#243;gico de bi&#243;psia de les&#227;o axilar evidenciou epiderme com espongiose discreta&#44; infiltrado d&#233;rmico&#44; linfo&#8208;histiocit&#225;rio&#44; perivascular moderado e vasodilata&#231;&#227;o&#46; Aus&#234;ncia de queratin&#243;citos necr&#243;ticos e de derrame pigmenta afastaram eritema pigmentar fixo &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Portanto&#44; os dados da hist&#243;ria cl&#237;nica&#44; dermatol&#243;gicos e histol&#243;gicos&#44; permitiram o diagn&#243;stico de SDRIFE associada ao paracetamol&#46; As les&#245;es desapareceram em poucas semanas ap&#243;s suspens&#227;o do f&#225;rmaco e uso de corticoide t&#243;pico&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Em&#160;2011&#44; Miyahara et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> propuseram classifica&#231;&#227;o da SB em quatro subtipos&#58; 1&#41; SB cl&#225;ssica&#44; resultante de sensibiliza&#231;&#227;o por al&#233;rgenos de contato e desencadeada por exposi&#231;&#227;o sist&#234;mica aos mesmos&#59; 2&#41; SB induzida por contato com f&#225;rmacos&#44; desencadeada por absor&#231;&#227;o ap&#243;s reexposi&#231;&#227;o cut&#226;nea&#59; 3&#41; SB induzida por sensibiliza&#231;&#227;o sist&#234;mica e quadro desencadeado por exposi&#231;&#227;o cut&#226;nea ao f&#225;rmaco&#59; e 4&#41; SDRIFE&#44; que corresponde &#224; sensibiliza&#231;&#227;o sist&#234;mica e manifesta&#231;&#227;o quando da reexposi&#231;&#227;o sist&#234;mica&#44; excluindo&#8208;se al&#233;rgenos de contato&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> Clinicamente&#44; o SDRIFE caracteriza&#8208;se por exantema sim&#233;trico na &#225;rea gl&#250;tea&#44; intergl&#250;tea e inguinal&#44; al&#233;m do envolvimento de pelo menos uma &#225;rea intertriginosa e flexural como axilar&#44; cubital e popl&#237;tea e considerada manifesta&#231;&#227;o infrequente e benigna de rea&#231;&#227;o de hipersensibilidade com aus&#234;ncia de sintomas sist&#234;micos&#46; O in&#237;cio &#233; de horas a dois dias ap&#243;s exposi&#231;&#227;o ao agente causal&#46; As medica&#231;&#245;es mais relacionadas s&#227;o os beta lact&#226;micos&#44; em particular a amoxicilina&#44; sulfam&#237;dicos&#44; anti&#8208;inflamat&#243;rios&#44; barbit&#250;ricos&#44; tetraciclinas e carbamazepina&#46; Na literatura&#44; h&#225; somente dois casos relatados de SDRIFE associados ao uso de paracetamol&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A patog&#234;nese n&#227;o &#233; completamente compreendida&#44; mas&#44; como na dermatite al&#233;rgica de contato&#44; o quadro sugere rea&#231;&#227;o de hipersensibilidade tardia mediada por c&#233;lulas&#160;T&#46; A maior densidade de gl&#226;ndulas sudor&#237;paras &#233;crinas nas regi&#245;es de dobras explicaria sua manifesta&#231;&#227;o restrita ou predominante &#224;s localiza&#231;&#245;es intertriginosas&#44; onde a excre&#231;&#227;o do f&#225;rmaco sensibilizante precipitaria a dermatose&#46; O tratamento implica na suspei&#231;&#227;o e interrup&#231;&#227;o dos f&#225;rmacos em uso&#46; Os corticoides de uso t&#243;pico ou sist&#234;mico podem acelerar a resolu&#231;&#227;o&#46; Relatos de casos e identifica&#231;&#227;o do f&#225;rmaco desencadeante s&#227;o &#250;teis do ponto de vista did&#225;tico e epidemiol&#243;gico&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0030" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0035" class="elsevierStylePara elsevierViewall">Joana Alexandria Ferreira Dias&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Luana Moraes Campos&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Juliano Vilaverde Schmitt&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">S&#237;lvio Alencar Marques&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0055" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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Article information
ISSN: 26662752
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