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do Anexo de Dermatologia do Hospital das Cl&#237;nicas da Universidade Federal de Minas Gerais &#40;UFMG&#41;&#44; que apresentavam suspeita de fotodermatose por les&#245;es eczematosas em &#225;reas expostas e agravadas com a exposi&#231;&#227;o solar&#44; ap&#243;s testes epicut&#226;neos que n&#227;o mostraram relev&#226;ncia cl&#237;nica&#44; com a bateria padr&#227;o brasileira&#44; foram selecionados para o FPT com fins diagn&#243;sticos&#46; Usaram&#8208;se al&#233;rgenos da FDA&#8208;Allergenic&#44; RJ e Chemotechnique Diagnostics &#8722; Su&#233;cia &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41; em Finn Chambers&#174; com Scanpor&#174; &#40;Smartpractice&#44; EUA&#41; ou Allergochambers&#174; &#40;Neoflex&#44; S&#227;o Paulo&#41; aplicados em duplicata na pele do dorso&#46; O conjunto de al&#233;rgenos testado foi escolhido com base na literatura e que estavam dispon&#237;veis em nosso servi&#231;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;5</span></a> Removidos 48 horas depois&#44; foram feitas leituras e um conjunto de al&#233;rgenos coberto com compressa cir&#250;rgica e folha de alum&#237;nio&#46; Como nenhum paciente apresentou dose eritematosa m&#237;nima menor que 10<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> de UVA&#44; irradiou&#8208;se o outro conjunto de al&#233;rgenos com 10<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; seguido de leitura imediata e posterior oclus&#227;o&#46; Novas leituras foram feitas 48 horas depois&#44; pelos crit&#233;rios do ICDRG &#40;International Contact Dermatitis Research Group&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Se apenas o lado irradiado mostrasse rea&#231;&#227;o positiva&#44; o diagn&#243;stico seria de rea&#231;&#227;o fotoal&#233;rgica de contato&#46; Se ambos os lados tivessem rea&#231;&#245;es positivas&#44; mas a do irradiado fosse maior&#44; o diagn&#243;stico seria de fotodermatite e dermatite al&#233;rgicas de contato e se as rea&#231;&#245;es fossem iguais em ambos os lados&#44; de dermatite al&#233;rgica de contato &#40;DAC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Entre&#160;os 1&#46;712 pacientes submetidos aos testes epicut&#226;neos&#44; foram selecionados 37 &#40;2&#44;2&#37;&#41;&#44; dos quais 19 eram homens &#40;51&#44;4&#37;&#41; e 18 eram mulheres &#40;48&#44;6&#37;&#41;&#44; entre 30&#8208;80 anos&#59; 22 &#40;59&#44;4&#37;&#41; apresentavam fototipos II e III&#44; 7&#160;&#40;19&#37;&#41; com fototipos IV e V e 8 &#40;21&#44;6&#37;&#41; com fototipo VI&#46; Seis pacientes &#40;16&#44;2&#37;&#41; tinham hist&#243;ria de atopia&#44; 15 &#40;40&#44;5&#37;&#41; usavam protetores solares&#44; 31 &#40;84&#37;&#41; tinham profiss&#245;es variadas&#44; 4 &#40;11&#37;&#41; eram pedreiros e 2 &#40;5&#44;4&#37;&#41; eram lavradores&#46; O tempo de evolu&#231;&#227;o das les&#245;es variava de 5 meses a 20 anos e os locais mais afetados eram &#225;reas expostas&#44; 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6&#59; 16&#37;&#41;&#44; ao perfume mix &#40;n &#61; 5&#59; 13&#44;5&#37;&#41;&#44; &#224; prometazina&#44; clorexidina e ao bicromato de pot&#225;ssio &#40;n &#61; 4&#59; 11&#37;&#41;&#44; &#224; oxibenzona e BHT &#40;n &#61; 3&#59; 8&#37;&#41;&#44; &#224; parafenilenodiamina e ao <span class="elsevierStyleItalic">Compositae</span> mix &#40;n &#61; 2&#59; 5&#44;4&#37;&#41;&#44; ao <span class="elsevierStyleItalic">sesquiterpene lactone</span> mix&#44; tioureia e butilmetoxibenzoilmetano &#40;n &#61; 1&#59; 2&#44;7&#37;&#41;&#46; Seis pacientes &#40;16&#37;&#41; tiveram testes negativos em ambos os lados testados&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Rea&#231;&#245;es positivas aos FPT s&#227;o causadas principalmente por anti&#8208;inflamat&#243;rios t&#243;picos&#44; como cetoprofeno&#44; muito usado na Europa&#46; Estudos mostram cossensibiliza&#231;&#227;o com benzofenonas&#44; fenofibrato e perfume mix&#46; Rea&#231;&#245;es a outros anti&#8208;inflamat&#243;rios como etofenamato e diclofenaco s&#227;o descritas&#46; Esses s&#227;o os fotoal&#233;rgenos mais frequentes na Europa&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Nos Estados Unidos&#44; filtros solares e antibacterianos s&#227;o os fotoal&#233;rgenos mais frequentes&#44; com redu&#231;&#227;o progressiva da incid&#234;ncia por fragr&#226;ncias&#46; Na &#205;ndia&#44; <span class="elsevierStyleItalic">Pathernium</span> &#233; o mais comum&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> N&#227;o existem dados publicados no Brasil&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Nos pacientes investigados&#44; rea&#231;&#245;es a clorpromazina foram as mais frequentes&#44; como ocorreu em s&#233;rie chinesa&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Trata&#8208;se de antipsic&#243;tico derivado da fenotiazina cujos an&#225;logos como di&#8208;hidroclorotiazida e prometazina s&#227;o muito usados como diur&#233;tico e antipruriginoso no pa&#237;s&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Prometazina foi o quarto fotoal&#233;rgeno&#44; assim como clorexidina e bicromato de pot&#225;ssio&#44; mas apenas um paciente mostrou correa&#231;&#227;o entre clorpromazina e prometazina&#46; O segundo em frequ&#234;ncia foi o b&#225;lsamo do Peru&#44; seguido de perfume mix&#46; Em pesquisa chinesa&#44; o bicromato de pot&#225;ssio tamb&#233;m foi o quarto fotoal&#233;rgeno em frequ&#234;ncia&#44; mostrou mais uma semelhan&#231;a&#44; al&#233;m da clorpromazina&#44; com nosso estudo&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Diferen&#231;as no padr&#227;o de fotopositividade variam de acordo com a &#225;rea e a popula&#231;&#227;o estudada&#46; Esta &#233; uma investiga&#231;&#227;o preliminar&#44; que refletiu h&#225;bitos da popula&#231;&#227;o&#44; como uso de prometazina por via oral e t&#243;pica como antipruriginoso e exposi&#231;&#227;o profissional ou dom&#233;stica ao cimento&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sugere&#8208;se a padroniza&#231;&#227;o de uma bateria para FPT no pa&#237;s <span class="elsevierStyleBold">&#40;</span>esse conjunto de al&#233;rgenos usado seria sugest&#227;o preliminar para se estabelecer uma bateria brasileira para testes fotoepicut&#226;neos&#41;&#44; uma vez que &#233; uma ferramenta eficaz e importante no diagn&#243;stico de dermatites fotossens&#237;veis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0045" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0050" class="elsevierStylePara elsevierViewall">Maria Antonieta Rios Scherrer&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; 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                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Oxibenzona &#40;benzofenona&#8208;3&#41; 10&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sesquiterpene lactone</span> mix 0&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Musk chileno 1&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Prometazina 1&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Perfume mix 7&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Irgasan 1&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Bicromato de pot&#225;ssio 0&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Hidrocloreto de clorpromazina 0&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tioureia 0&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Clorexidina 0&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;gua&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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Carta – Investigação
Testes fotoepicutâneos: série de 37 pacientes brasileiros
Maria Antonieta Rios Scherrer, Vanessa Barreto Rocha
Corresponding author
vanessabarreto.vbr@gmail.com

Autor para correspondência.
Ambulatório de Dermatologia, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
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do Anexo de Dermatologia do Hospital das Cl&#237;nicas da Universidade Federal de Minas Gerais &#40;UFMG&#41;&#44; que apresentavam suspeita de fotodermatose por les&#245;es eczematosas em &#225;reas expostas e agravadas com a exposi&#231;&#227;o solar&#44; ap&#243;s testes epicut&#226;neos que n&#227;o mostraram relev&#226;ncia cl&#237;nica&#44; com a bateria padr&#227;o brasileira&#44; foram selecionados para o FPT com fins diagn&#243;sticos&#46; Usaram&#8208;se al&#233;rgenos da FDA&#8208;Allergenic&#44; RJ e Chemotechnique Diagnostics &#8722; Su&#233;cia &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41; em Finn Chambers&#174; com Scanpor&#174; &#40;Smartpractice&#44; EUA&#41; ou Allergochambers&#174; &#40;Neoflex&#44; S&#227;o Paulo&#41; aplicados em duplicata na pele do dorso&#46; O conjunto de al&#233;rgenos testado foi escolhido com base na literatura e que estavam dispon&#237;veis em nosso servi&#231;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;5</span></a> Removidos 48 horas depois&#44; foram feitas leituras e um conjunto de al&#233;rgenos coberto com compressa cir&#250;rgica e folha de alum&#237;nio&#46; Como nenhum paciente apresentou dose eritematosa m&#237;nima menor que 10<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> de UVA&#44; irradiou&#8208;se o outro conjunto de al&#233;rgenos com 10<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; seguido de leitura imediata e posterior oclus&#227;o&#46; Novas leituras foram feitas 48 horas depois&#44; pelos crit&#233;rios do ICDRG &#40;International Contact Dermatitis Research Group&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Se apenas o lado irradiado mostrasse rea&#231;&#227;o positiva&#44; o diagn&#243;stico seria de rea&#231;&#227;o fotoal&#233;rgica de contato&#46; Se ambos os lados tivessem rea&#231;&#245;es positivas&#44; mas a do irradiado fosse maior&#44; o diagn&#243;stico seria de fotodermatite e dermatite al&#233;rgicas de contato e se as rea&#231;&#245;es fossem iguais em ambos os lados&#44; de dermatite al&#233;rgica de contato &#40;DAC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Entre&#160;os 1&#46;712 pacientes submetidos aos testes epicut&#226;neos&#44; foram selecionados 37 &#40;2&#44;2&#37;&#41;&#44; dos quais 19 eram homens &#40;51&#44;4&#37;&#41; e 18 eram mulheres &#40;48&#44;6&#37;&#41;&#44; entre 30&#8208;80 anos&#59; 22 &#40;59&#44;4&#37;&#41; apresentavam fototipos II e III&#44; 7&#160;&#40;19&#37;&#41; com fototipos IV e V e 8 &#40;21&#44;6&#37;&#41; com fototipo VI&#46; Seis pacientes &#40;16&#44;2&#37;&#41; tinham hist&#243;ria de atopia&#44; 15 &#40;40&#44;5&#37;&#41; usavam protetores solares&#44; 31 &#40;84&#37;&#41; tinham profiss&#245;es variadas&#44; 4 &#40;11&#37;&#41; eram pedreiros e 2 &#40;5&#44;4&#37;&#41; eram lavradores&#46; O tempo de evolu&#231;&#227;o das les&#245;es variava de 5 meses a 20 anos e os locais mais afetados eram &#225;reas expostas&#44; predominaram face &#40;33&#37;&#8208;89&#37;&#41;&#44; membros superiores &#40;25&#37;&#8208;67&#37;&#41; e pesco&#231;o &#40;24&#37;&#8208;65&#37;&#41;&#46; Tr&#234;s pacientes &#40;8&#37;&#41; apresentaram les&#245;es disseminadas&#46; Teste de contato pr&#233;vio mostrou rea&#231;&#245;es para Kathon e <span class="elsevierStyleItalic">quaternium</span> 15 em um paciente&#44; formalde&#237;do em um e bicromato de pot&#225;ssio em dois&#59; um paciente apresentava rea&#231;&#245;es a n&#237;quel&#44; timerosal e hidroquinona&#46; Foram observadas 74 rea&#231;&#245;es positivas&#44; das quais 54 ocorreram no lado irradiado e 20 no lado n&#227;o irradiado&#44; o que levou aos diagn&#243;sticos de FDAC em 23 &#40;62&#37;&#41; pacientes e de DAC em 12 &#40;32&#37;&#41; &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1 e 2</a>&#41;&#46; As rea&#231;&#245;es fotoal&#233;rgicas detectadas foram &#224; clorpromazina &#40;n &#61; 9&#59; 24&#37;&#41;&#44; ao b&#225;lsamo do Peru &#40;n &#61; 6&#59; 16&#37;&#41;&#44; ao perfume mix &#40;n &#61; 5&#59; 13&#44;5&#37;&#41;&#44; &#224; prometazina&#44; clorexidina e ao bicromato de pot&#225;ssio &#40;n &#61; 4&#59; 11&#37;&#41;&#44; &#224; oxibenzona e BHT &#40;n &#61; 3&#59; 8&#37;&#41;&#44; &#224; parafenilenodiamina e ao <span class="elsevierStyleItalic">Compositae</span> mix &#40;n &#61; 2&#59; 5&#44;4&#37;&#41;&#44; ao <span class="elsevierStyleItalic">sesquiterpene lactone</span> mix&#44; tioureia e butilmetoxibenzoilmetano &#40;n &#61; 1&#59; 2&#44;7&#37;&#41;&#46; Seis pacientes &#40;16&#37;&#41; tiveram testes negativos em ambos os lados testados&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Rea&#231;&#245;es positivas aos FPT s&#227;o causadas principalmente por anti&#8208;inflamat&#243;rios t&#243;picos&#44; como cetoprofeno&#44; muito usado na Europa&#46; Estudos mostram cossensibiliza&#231;&#227;o com benzofenonas&#44; fenofibrato e perfume mix&#46; Rea&#231;&#245;es a outros anti&#8208;inflamat&#243;rios como etofenamato e diclofenaco s&#227;o descritas&#46; Esses s&#227;o os fotoal&#233;rgenos mais frequentes na Europa&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Nos Estados Unidos&#44; filtros solares e antibacterianos s&#227;o os fotoal&#233;rgenos mais frequentes&#44; com redu&#231;&#227;o progressiva da incid&#234;ncia por fragr&#226;ncias&#46; Na &#205;ndia&#44; <span class="elsevierStyleItalic">Pathernium</span> &#233; o mais comum&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> N&#227;o existem dados publicados no Brasil&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Nos pacientes investigados&#44; rea&#231;&#245;es a clorpromazina foram as mais frequentes&#44; como ocorreu em s&#233;rie chinesa&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Trata&#8208;se de antipsic&#243;tico derivado da fenotiazina cujos an&#225;logos como di&#8208;hidroclorotiazida e prometazina s&#227;o muito usados como diur&#233;tico e antipruriginoso no pa&#237;s&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Prometazina foi o quarto fotoal&#233;rgeno&#44; assim como clorexidina e bicromato de pot&#225;ssio&#44; mas apenas um paciente mostrou correa&#231;&#227;o entre clorpromazina e prometazina&#46; O segundo em frequ&#234;ncia foi o b&#225;lsamo do Peru&#44; seguido de perfume mix&#46; Em pesquisa chinesa&#44; o bicromato de pot&#225;ssio tamb&#233;m foi o quarto fotoal&#233;rgeno em frequ&#234;ncia&#44; mostrou mais uma semelhan&#231;a&#44; al&#233;m da clorpromazina&#44; com nosso estudo&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Diferen&#231;as no padr&#227;o de fotopositividade variam de acordo com a &#225;rea e a popula&#231;&#227;o estudada&#46; Esta &#233; uma investiga&#231;&#227;o preliminar&#44; que refletiu h&#225;bitos da popula&#231;&#227;o&#44; como uso de prometazina por via oral e t&#243;pica como antipruriginoso e exposi&#231;&#227;o profissional ou dom&#233;stica ao cimento&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sugere&#8208;se a padroniza&#231;&#227;o de uma bateria para FPT no pa&#237;s <span class="elsevierStyleBold">&#40;</span>esse conjunto de al&#233;rgenos usado seria sugest&#227;o preliminar para se estabelecer uma bateria brasileira para testes fotoepicut&#226;neos&#41;&#44; uma vez que &#233; uma ferramenta eficaz e importante no diagn&#243;stico de dermatites fotossens&#237;veis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0045" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0050" class="elsevierStylePara elsevierViewall">Maria Antonieta Rios Scherrer&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; 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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prometazina 1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perfume mix 7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Irgasan 1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bicromato de pot&#225;ssio 0&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hidrocloreto de clorpromazina 0&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tioureia 0&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clorexidina 0&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;gua&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parafenilenodiamina 1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Compositae</span> mix 5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BHT &#40;butil hidroxitolueno&#41; 2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaselina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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Article information
ISSN: 26662752
Original language: Portuguese
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Idiomas
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