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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 73-year-old woman presented with less than a 1-year history of an erythematous&#44; well-delimited and shiny lesion on her left buttock&#44; near the gluteal fold &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Dermoscopic examination showed dotted vessels arranged in a linear pattern involving the entire lesion&#46; These vascular findings are also called metaphorically a &#8216;string of pearls&#8217; pattern&#46; Another vascular pattern observed on the periphery of the lesion is that of branched vessels with rounded endings&#46; Surprisingly&#44; dermoscopy also revealed multiple rosettes &#40;also known as &#8216;four-clod dots&#8217;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Differential diagnoses included mainly clear cell acanthoma&#44; irritated seborrheic keratosis&#44; Bowen&#180;s disease and eccrine poroma&#46; The lesion was completely surgically removed and histopathologic examination revealed an epidermic lesion with marked psoriasiform hyperplasia&#44; in which epidermal cells show clear cytoplasms &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; These findings are consistent with the diagnosis of Clear Cell Acanthoma &#40;CCA&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">CCA is an uncommon benign epidermal lesion of unknown etiology&#44; although a recent hypothesis suggests its reactive origin&#46; The typical presentation is a red to brown&#44; dome-shaped papule or plaque on the lower extremities&#44; with a peak of age incidence of 60-years&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; like in this case&#44; it can appear in unusual locations&#46; Clinical differential diagnosis includes a wide range of cutaneous neoplasms&#44; including malignant lesions such as squamous cell carcinoma or amelanotic melanoma&#46; Indeed&#44; it is frequently mistaken clinically for other skin lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In this setting&#44; almost unique dermoscopic findings can be a useful tool to suspect this diagnosis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On dermoscopy CCA is highly characteristic&#44; showing dotted or glomerular vessels arranged in a linear or serpiginous pattern&#46; These linear arrangements usually adopt a reticular distribution&#44; forming what is known as a &#8216;string of pearls&#8217; pattern&#44; of which this case is very representative&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In this sense&#44; these stereotypical dermoscopic findings can be helpful in the setting of otherwise nonspecific lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Other dermoscopic findings reported in CCA are&#44; in order of frequency&#44; a pale pink background&#44; a collarette of translucent scales&#44; hemorrhagic areas&#44; orange crusts&#44; and crystalline structures&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Otherwise&#44; branched vessels with rounded terminal endings are not typical of CCA&#46; Moreover&#44; these dermoscopic finding is positively associated with the diagnosis of eccrine poroma&#44; which is one of the main differential diagnoses of CCA&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In the studied patient&#44; they were distributed along the entire periphery of the lesion&#44; showing various morphologies such as a chalice-like or leaf-like shape&#46; This peripheral distribution could suggest that&#44; in this case&#44; vessel type depends more on the viewing angle on dermoscopy than on the morphology of these vessels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Rosettes are dermoscopic structures only observed under polarized light&#46; They are also called &#8216;four-clod dots&#8217; and&#44; first believed to be specific for actinic keratosis and squamous cell carcinoma&#44; currently&#44; they are not considered lesion-specific and can also be observed in another type of skin lesions&#46; Rosettes are considered to be an optical effect of crossed polarization by concentric fibrosis or horny material&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> To the authors&#8217; knowledge&#44; there are no previous reports showing this structure end CCA&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; the authors report a case of CCA with an unusual location&#44; showing uncommon dermoscopic findings&#44; classically associated with other cutaneous lesions such as actinic keratosis or eccrine poroma&#46; Although the &#8216;string of pearls&#8217; pattern is highly characteristic&#44; CCA can show other dermoscopic features that should be known in order to make an accurate differential diagnosis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Marcial &#193;lvarez-Salafranca&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; participation in the design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Mar Garc&#237;a-Garc&#237;a&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the manuscript&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Andrea Montes-Torres&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the manuscript&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Mariano Ara-Mart&#237;n&#58; Approval of the final version of the manuscript&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
Hidden clear cell acanthoma with uncommon dermoscopic findings
Marcial Álvarez-Salafranca
Corresponding author
malvarezs@salud.aragon.es

Corresponding author.
, Mar García-García, Andrea Montes-Torres, Mariano Ara-Martín
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 73-year-old woman presented with less than a 1-year history of an erythematous&#44; well-delimited and shiny lesion on her left buttock&#44; near the gluteal fold &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Dermoscopic examination showed dotted vessels arranged in a linear pattern involving the entire lesion&#46; These vascular findings are also called metaphorically a &#8216;string of pearls&#8217; pattern&#46; Another vascular pattern observed on the periphery of the lesion is that of branched vessels with rounded endings&#46; Surprisingly&#44; dermoscopy also revealed multiple rosettes &#40;also known as &#8216;four-clod dots&#8217;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Differential diagnoses included mainly clear cell acanthoma&#44; irritated seborrheic keratosis&#44; Bowen&#180;s disease and eccrine poroma&#46; The lesion was completely surgically removed and histopathologic examination revealed an epidermic lesion with marked psoriasiform hyperplasia&#44; in which epidermal cells show clear cytoplasms &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; These findings are consistent with the diagnosis of Clear Cell Acanthoma &#40;CCA&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">CCA is an uncommon benign epidermal lesion of unknown etiology&#44; although a recent hypothesis suggests its reactive origin&#46; The typical presentation is a red to brown&#44; dome-shaped papule or plaque on the lower extremities&#44; with a peak of age incidence of 60-years&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; like in this case&#44; it can appear in unusual locations&#46; Clinical differential diagnosis includes a wide range of cutaneous neoplasms&#44; including malignant lesions such as squamous cell carcinoma or amelanotic melanoma&#46; Indeed&#44; it is frequently mistaken clinically for other skin lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In this setting&#44; almost unique dermoscopic findings can be a useful tool to suspect this diagnosis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On dermoscopy CCA is highly characteristic&#44; showing dotted or glomerular vessels arranged in a linear or serpiginous pattern&#46; These linear arrangements usually adopt a reticular distribution&#44; forming what is known as a &#8216;string of pearls&#8217; pattern&#44; of which this case is very representative&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In this sense&#44; these stereotypical dermoscopic findings can be helpful in the setting of otherwise nonspecific lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Other dermoscopic findings reported in CCA are&#44; in order of frequency&#44; a pale pink background&#44; a collarette of translucent scales&#44; hemorrhagic areas&#44; orange crusts&#44; and crystalline structures&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Otherwise&#44; branched vessels with rounded terminal endings are not typical of CCA&#46; Moreover&#44; these dermoscopic finding is positively associated with the diagnosis of eccrine poroma&#44; which is one of the main differential diagnoses of CCA&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In the studied patient&#44; they were distributed along the entire periphery of the lesion&#44; showing various morphologies such as a chalice-like or leaf-like shape&#46; This peripheral distribution could suggest that&#44; in this case&#44; vessel type depends more on the viewing angle on dermoscopy than on the morphology of these vessels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Rosettes are dermoscopic structures only observed under polarized light&#46; They are also called &#8216;four-clod dots&#8217; and&#44; first believed to be specific for actinic keratosis and squamous cell carcinoma&#44; currently&#44; they are not considered lesion-specific and can also be observed in another type of skin lesions&#46; Rosettes are considered to be an optical effect of crossed polarization by concentric fibrosis or horny material&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> To the authors&#8217; knowledge&#44; there are no previous reports showing this structure end CCA&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; the authors report a case of CCA with an unusual location&#44; showing uncommon dermoscopic findings&#44; classically associated with other cutaneous lesions such as actinic keratosis or eccrine poroma&#46; Although the &#8216;string of pearls&#8217; pattern is highly characteristic&#44; CCA can show other dermoscopic features that should be known in order to make an accurate differential diagnosis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Marcial &#193;lvarez-Salafranca&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; participation in the design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Mar Garc&#237;a-Garc&#237;a&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the manuscript&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Andrea Montes-Torres&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the manuscript&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Mariano Ara-Mart&#237;n&#58; Approval of the final version of the manuscript&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Idiomas
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