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Tropical/Infectoparasitary Dermatology
Tumor-like herpes simplex infection in an HIV patient
Lula María Nieto-Benito
Corresponding author
lula.m.nieto@gmail.com

Corresponding author.
, Ángel Manuel Rosell-Díaz, Ana Pulido-Pérez, Ricardo Maria Suárez-Fernández
Department of Dermatology, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 56-year-old male&#44; HIV-positive&#44; presented with a 3-day history of painful lesions on his right gluteus&#46; He denied a prior diagnosis of genital herpes&#46; The patient had been on antiviral medication since diagnosis and his viral load was undetectable with a CD4 cell count of 942 cells&#47;&#181;L&#46; He denied any systemic symptoms&#46; During the physical examination&#44; multiple indurated erythematous nodules with superficial and well-defined erosions were noted &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Skin biopsy was performed for histopathological studies and microbiological cultures&#46; Blood analysis was within normal values&#46; Biopsy of one of the lesions showed ballooning-necrotic keratinocytes and acantholysis with inflammation extending to subcutaneous tissue &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; A diagnosis of nodular cutaneous and herpes simplex infection was made&#46; Cultures supported the diagnosis as they were positive for Herpes simplex 2 and negative for bacteria mycobacteria and fungi&#46; Valacyclovir was initiated and followed by complete resolution within 7-days&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Genital herpes simplex infection recurrences may not be limited to the anterior part of the genitalia and clinical presentation in the lumbar area or gluteus must be differentiated from a varicella-zoster virus infection&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> HSV polymerase chain reaction-based testing and cell culture of the lesion can be helpful to determine the causative virus&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Tumor-like presentation is a very rare manifestation of HSV cutaneous infection&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> It is important to take this morphological variant into consideration not to delay the diagnosis of a viral infection&#44; especially in an immunosuppressed patient&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Nodular genital herpes simplex is a very rare form of clinical presentation&#59; only one case has been reported in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a> The authors describe a case of cutaneous HSV &#40;herpes simplex virus&#41; infection in an HIV patient that clinically presented with a nodular configuration&#44; mimicking a tumor&#44; supported by histopathology and microbiological cultures&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financial support</span><p id="par0015" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors&#39; contributions</span><p id="par0020" class="elsevierStylePara elsevierViewall">Lula Mar&#237;a Nieto-Benito&#58; Have conceived and designed the analysis&#59; collected the data&#59; contributed data or analysis tools&#59; performed the analysis&#59; written the paper and approved its final version&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">&#193;ngel Manuel Rosell-D&#237;az&#58; Have collected the data and approved its final version&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Ana Pulido-P&#233;rez &#58; Have conceived and designed the analysis&#59; collected the data&#59; contributed data or analysis tools&#59; performed the analysis&#59; written the paper and approved its final version&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Ricardo Maria Su&#225;rez-Fern&#225;ndez &#58; Have conceived and designed the analysis&#59; collected the data&#59; contributed data or analysis tools&#59; performed the analysis&#59; written the paper and approved its final version&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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