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The patient denied trauma or fever&#59; she had undergone treatment with antibiotics&#44; without improvement&#46; She reported type II diabetes mellitus and systemic arterial hypertension&#46; The dermatological examination showed phagedenic ulcers&#44; with necrotic areas&#44; surrounded by an inflammatory halo &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; The lesions were more exuberant in the deltoid regions&#44; with satellite lesions on the shoulders and forearms&#46; The supplemental clinical examination was normal&#44; although the patient presented depression symptoms and was suffering from her illness&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The clinical hypothesis was that of pyoderma gangrenosum&#44; due to the presence of painful ulcers&#44; of rapid growth and geographical aspect&#59; however&#44; no violet halo was observed and the edges were not undermined&#46; Another hypothesis was primary cutaneous cryptococcosis&#44; due to the inflammatory aspect associated with necrosis&#44; localized in exposed areas&#59; however&#44; the bilateral aspect of the lesions did not correspond to this hypothesis&#46; Biopsies and laboratory investigation were performed&#59; the final diagnosis of paracoccidioidomycosis was surprising and confirmed by histopathological examination &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 4</a>&#41; and direct mycological examination&#46; Complementary tests&#44; including chest and abdominal computed tomography &#40;CT&#41;&#44; ruled out involvement of other organs&#46; Laboratory tests revealed elevated CRP and glycemia&#44; negative HIV and anti-<span class="elsevierStyleItalic">P&#46; brasiliensis</span> serology&#44; and negative culture for bacteria and fungi&#46; The clinical response was complete after treatment with itraconazole 400<span class="elsevierStyleHsp" style=""></span>mg&#47;day in the first month&#44; decreased to 200<span class="elsevierStyleHsp" style=""></span>mg&#47;day until the sixth month of treatment&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The present case differs from the usual pattern of paracoccidioidomycosis in several aspects&#46; The disease is uncommon in both female and elderly patients&#46; As a rule&#44; lung involvement is present in adult patients&#44; being the source of metastatic spread of the infection to other organs&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> Pulmonary involvement was not observed in the present case&#44; even using high-resolution CT&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> Nonetheless&#44; the most unusual finding was the pattern of skin lesions&#46; In paracoccidioidomycosis&#44; skin lesions are observed in up to 62&#46;1&#37; of cases&#44; usually on the face&#44; such as acneiform lesions&#44; in infiltrated plaques&#44; or vegetating and simultaneously with multiple organ involvement&#44; including the lungs&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> Ulcers with necrotic areas are uncommon&#44; as the skin ulcers in paracoccidioidomycosis are generally shallow&#44; granular&#44; and usually with hemorrhagic spots&#44; similar to what is observed in mucosal lesions&#59; they are not phagedenic or painful&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient&#39;s advanced age&#44; immunosenescence&#44; and diabetes probably contributed to the rapid evolution and atypical presentation in this case&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">6&#44;7</span></a> Itraconazole has been considered as the first treatment option and is effective at a dose of 200<span class="elsevierStyleHsp" style=""></span>mg&#47;day for 9&#8211;18 months&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> In the present study&#44; itraconazole was successfully used at 400<span class="elsevierStyleHsp" style=""></span>mg&#47;day in the first month with the aim of promoting quick resolution of injuries&#44; improving quality of life&#44; and reducing the psychological stress experienced by the patient&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financial support</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors&#8217; contribution</span><p id="par0035" class="elsevierStylePara elsevierViewall">Bruno Augusto Alvares&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cl&#225;udia Alves Lapa Gracia&#58; Approval of the final version of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the manuscript&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Mariangela Esther Alencar Marques&#58; Approval of the final version of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the manuscript&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Silvio Alencar Marques&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Tropical/Infectoparasitary Dermatology
Paracoccidioidomycosis: an uncommon clinical presentation
Bruno Augusto Alvaresa, Cláudia Alves Lapa Graciab, Mariangela Esther Alencar Marquesa, Silvio Alencar Marquesa,
Corresponding author
silvio.marques@unesp.br

Corresponding author.
a Department of Dermatology and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brazil
b Private Clinic, Birigui, SP, Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Paracoccidioidomycosis is a systemic mycosis caused by dimorphic fungi of the genus <span class="elsevierStyleItalic">Paracoccidioides</span> &#40;<span class="elsevierStyleItalic">P&#46; brasiliensis</span> or <span class="elsevierStyleItalic">P&#46; lutzii</span>&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> which&#44; in the chronic clinical presentation in adults&#44; mainly affects men &#40;male&#47;female ratio&#58; up to 22&#47;1&#41; in the range from 30 to 59 years old&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> Lung and oral mucosa involvement is usual in this clinical form&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The authors report a case of a 76-year-old female patient with painful skin lesions two months prior to presentation&#46; The patient denied trauma or fever&#59; she had undergone treatment with antibiotics&#44; without improvement&#46; She reported type II diabetes mellitus and systemic arterial hypertension&#46; The dermatological examination showed phagedenic ulcers&#44; with necrotic areas&#44; surrounded by an inflammatory halo &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; The lesions were more exuberant in the deltoid regions&#44; with satellite lesions on the shoulders and forearms&#46; The supplemental clinical examination was normal&#44; although the patient presented depression symptoms and was suffering from her illness&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The clinical hypothesis was that of pyoderma gangrenosum&#44; due to the presence of painful ulcers&#44; of rapid growth and geographical aspect&#59; however&#44; no violet halo was observed and the edges were not undermined&#46; Another hypothesis was primary cutaneous cryptococcosis&#44; due to the inflammatory aspect associated with necrosis&#44; localized in exposed areas&#59; however&#44; the bilateral aspect of the lesions did not correspond to this hypothesis&#46; Biopsies and laboratory investigation were performed&#59; the final diagnosis of paracoccidioidomycosis was surprising and confirmed by histopathological examination &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 4</a>&#41; and direct mycological examination&#46; Complementary tests&#44; including chest and abdominal computed tomography &#40;CT&#41;&#44; ruled out involvement of other organs&#46; Laboratory tests revealed elevated CRP and glycemia&#44; negative HIV and anti-<span class="elsevierStyleItalic">P&#46; brasiliensis</span> serology&#44; and negative culture for bacteria and fungi&#46; The clinical response was complete after treatment with itraconazole 400<span class="elsevierStyleHsp" style=""></span>mg&#47;day in the first month&#44; decreased to 200<span class="elsevierStyleHsp" style=""></span>mg&#47;day until the sixth month of treatment&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The present case differs from the usual pattern of paracoccidioidomycosis in several aspects&#46; The disease is uncommon in both female and elderly patients&#46; As a rule&#44; lung involvement is present in adult patients&#44; being the source of metastatic spread of the infection to other organs&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> Pulmonary involvement was not observed in the present case&#44; even using high-resolution CT&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> Nonetheless&#44; the most unusual finding was the pattern of skin lesions&#46; In paracoccidioidomycosis&#44; skin lesions are observed in up to 62&#46;1&#37; of cases&#44; usually on the face&#44; such as acneiform lesions&#44; in infiltrated plaques&#44; or vegetating and simultaneously with multiple organ involvement&#44; including the lungs&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> Ulcers with necrotic areas are uncommon&#44; as the skin ulcers in paracoccidioidomycosis are generally shallow&#44; granular&#44; and usually with hemorrhagic spots&#44; similar to what is observed in mucosal lesions&#59; they are not phagedenic or painful&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient&#39;s advanced age&#44; immunosenescence&#44; and diabetes probably contributed to the rapid evolution and atypical presentation in this case&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">6&#44;7</span></a> Itraconazole has been considered as the first treatment option and is effective at a dose of 200<span class="elsevierStyleHsp" style=""></span>mg&#47;day for 9&#8211;18 months&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> In the present study&#44; itraconazole was successfully used at 400<span class="elsevierStyleHsp" style=""></span>mg&#47;day in the first month with the aim of promoting quick resolution of injuries&#44; improving quality of life&#44; and reducing the psychological stress experienced by the patient&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financial support</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors&#8217; contribution</span><p id="par0035" class="elsevierStylePara elsevierViewall">Bruno Augusto Alvares&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cl&#225;udia Alves Lapa Gracia&#58; Approval of the final version of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the manuscript&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Mariangela Esther Alencar Marques&#58; Approval of the final version of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the manuscript&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Silvio Alencar Marques&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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