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moderada ou grave de acordo com os crit&#233;rios morfol&#243;gicos da Organiza&#231;&#227;o Mundial da Sa&#250;de &#40;OMS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Para a an&#225;lise imuno&#8208;histoqu&#237;mica&#44; o material tratado com o anticorpo anti&#8208;8&#8208;OHdG &#40;Santa Cruz Biotechnology Cat&#35; sc&#8208;66036&#44; RRID&#58; AB 832272&#41; foi examinado por dois avaliadores previamente calibrados e cegados&#46; A an&#225;lise foi realizada por microscopia &#243;ptica nos aumentos de 100&#215; e 400&#215; no componente epitelial em toda a les&#227;o&#44; cuja extens&#227;o foi determinada pela &#225;rea de elastose solar no tecido conjuntivo e por altera&#231;&#245;es epiteliais&#44; se presentes&#46; Os casos foram categorizados com base em escore de imunorreatividade&#46; Para esse prop&#243;sito&#44; a intensidade da colora&#231;&#227;o foi avaliada primeiramente no epit&#233;lio e classificada da seguinte maneira&#58; 0 &#40;negativa&#41;&#44; 1 &#40;fraca&#41;&#44; 2 &#40;moderada&#41; e 3 &#40;forte&#41;&#46; Foi considerada a intensidade predominante em cada caso&#46; A imunomarca&#231;&#227;o foi analisada semiquantitativamente&#44; atribuindo&#8208;se os seguintes escores&#58; 0 &#40;negativo&#41;&#44; 1 &#40;1&#37; a 50&#37; de c&#233;lulas positivas&#41; e 2 &#40;51&#37; a 100&#37; de c&#233;lulas positivas&#41;&#46; As c&#233;lulas epiteliais que exibiam colora&#231;&#227;o marrom no n&#250;cleo e&#47;ou citoplasma foram classificadas como positivas&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;7</span></a> O escore de imunorreatividade foi ent&#227;o calculado multiplicando&#8208;se o escore de intensidade da colora&#231;&#227;o pelo escore da porcentagem de c&#233;lulas positivas&#46; O escore final de cada caso variou de 0 a 6&#44; em que 0&#8208;2 &#61; imunorreatividade fraca&#44; 3&#8208;4 &#61; imunorreatividade moderada e 5&#8208;6<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>imunorreatividade forte&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Houve predom&#237;nio de pacientes do sexo masculino &#40;72&#44;2&#37;&#41; e brancos &#40;64&#44;9&#37;&#41;&#44; n&#227;o fumantes ou ex&#8208;fumantes &#40;49&#44;2&#37;&#41;&#44; com idade igual ou superior a 40 anos &#40;93&#37;&#41; e com hist&#243;ria de exposi&#231;&#227;o cr&#244;nica &#224; radia&#231;&#227;o ultravioleta &#40;66&#44;7&#37;&#41;&#46; Manchas brancas foram a caracter&#237;stica cl&#237;nica mais frequente nos casos estudados &#40;56&#44;1&#37;&#41;&#44; seguidas de placa branca e descama&#231;&#227;o&#59; ulcera&#231;&#227;o foi menos comum &#40;10&#44;5&#37;&#59; <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Imunomarca&#231;&#227;o nas c&#233;lulas epiteliais foi observada em 100&#37; dos casos analisados&#44; principalmente nas camadas basal e parabasal do epit&#233;lio&#46; A imunomarca&#231;&#227;o foi predominantemente nuclear com colora&#231;&#227;o citoplasm&#225;tica de pequena intensidade em 39&#44;6&#37; dos casos e colora&#231;&#227;o predominantemente citoplasm&#225;tica em 12&#44;1&#37;&#44; enquanto a mesma intensidade foi observada no n&#250;cleo e citoplasma de 48&#44;3&#37; dos casos&#46; Forte imunorreatividade ao anticorpo foi detectada em 64&#44;9&#37; dos casos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; A imunomarca&#231;&#227;o no n&#250;cleo e no citoplasma pode ser explicada pelo fato de que 8&#8208;OHdG &#233; encontrada tanto no DNA nuclear quanto no mitocondrial&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#44;9</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">O estresse oxidativo no DNA estava presente independentemente das caracter&#237;sticas cl&#237;nicas das les&#245;es&#46; N&#227;o foram encontradas diferen&#231;as estatisticamente significantes na express&#227;o de 8&#8208;OHdG de acordo com as caracter&#237;sticas cl&#237;nicas das les&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41; ou presen&#231;a de tabagismo &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;266&#59; <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46; Prabhulkar e Li monitoraram a cin&#233;tica de libera&#231;&#227;o de 8&#8208;OhdG na superf&#237;cie de uma c&#233;lula epitelial pulmonar exposta &#224; nicotina para avaliar o dano oxidativo causado pelo tabaco&#59; os autores observaram que quanto maior o n&#237;vel de exposi&#231;&#227;o celular &#224; nicotina&#44; maior o dano oxidativo ao DNA&#44; promovendo aumento no n&#237;vel de 8&#8208;OhdG secretada pela c&#233;lula&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Nas amostras do presente estudo&#44; foram observados danos oxidativos ao DNA demonstrados pela presen&#231;a de 8&#8208;OhdG&#44; independentemente da exposi&#231;&#227;o dos indiv&#237;duos ao tabaco&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">A classifica&#231;&#227;o histopatol&#243;gica revelou algum grau de displasia epitelial em 87&#44;7&#37; dos casos&#46; Displasia epitelial de pequeno grau foi a mais comum &#40;38&#44;6&#37;&#41;&#44; seguida pela displasia epitelial moderada &#40;29&#44;8&#37;&#41; e acentuada &#40;19&#44;3&#37;&#41;&#46; Displasia epitelial esteve ausente em 12&#44;3&#37; dos casos&#46; Forte imunorreatividade foi observada na maioria dos casos&#44; independentemente da presen&#231;a de displasia epitelial ou de seu grau&#46; N&#227;o foi observada diferen&#231;a significante na express&#227;o de 8&#8208;OhdG entre os diferentes graus de displasia epitelial oral &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;225&#59; <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46; De maneira similar&#44; Yoshifuku et al&#46; tamb&#233;m encontraram predomin&#226;ncia de forte imunorreatividade com 8OHdG em les&#245;es de ceratose act&#237;nica &#40;presen&#231;a de displasia epitelial de pequeno grau ou moderada&#41; e doen&#231;a de Bowen &#40;displasia epitelial acentuada&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Esses achados podem ser explicados pelo fato de que a exposi&#231;&#227;o cr&#244;nica &#224; radia&#231;&#227;o ultravioleta desencadeia a produ&#231;&#227;o cont&#237;nua de esp&#233;cies reativas de oxig&#234;nio e estresse oxidativo e&#44; consequentemente&#44; a forma&#231;&#227;o constante de 8&#8208;OHdG&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Embora a express&#227;o de 8&#8208;OHdG seja &#250;til para a avalia&#231;&#227;o do dano oxidativo ao DNA e esteja bem estabelecida como indicador progn&#243;stico em diferentes tipos de c&#226;ncer&#44; com evid&#234;ncias sugerindo que o dano oxidativo ao DNA por meio da forma&#231;&#227;o de 8&#8208;OHdG est&#225; envolvido na patog&#234;nese e progress&#227;o do carcinoma espinocelular&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8&#44;10</span></a> os presentes resultados apontam para dificuldades na utiliza&#231;&#227;o desse marcador para estabelecer associa&#231;&#227;o com caracter&#237;sticas clinicodemogr&#225;ficas e com o grau morfol&#243;gico da queilite act&#237;nica&#44; uma vez que a 8&#8208;OHdG foi expressa de modo marcante na maioria dos casos analisados&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Os resultados do presente estudo confirmam que o estresse oxidativo por danos ao DNA desempenha papel na queilite act&#237;nica&#44; como sugerido pela forte express&#227;o imuno&#8208;histoqu&#237;mica de 8&#8208;OHdG nos casos analisados&#46; Entretanto&#44; a falta de diferen&#231;a significante na imunorreatividade anti&#8208;8&#8208;OHdG entre diferentes graus de displasia epitelial oral e fatores clinicodemogr&#225;ficos demonstra que esse marcador est&#225; alterado independentemente das caracter&#237;sticas cl&#237;nicas e do grau de displasia epitelial&#44; e as modifica&#231;&#245;es oxidativas da base do DNA s&#227;o um evento inicial na carcinog&#234;nese labial&#46; Assim&#44; tratamentos medicamentosos adjuvantes que minimizem os danos causados pelo estresse oxidativo&#44; como agentes antioxidantes t&#243;picos&#44; podem ser medidas terap&#234;uticas &#250;teis em pacientes com queilite act&#237;nica&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0055" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0060" class="elsevierStylePara elsevierViewall">C&#237;ntia Barreto de Oliveira Varela&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Cristianne Kalinne Santos Medeiros&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; an&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Jabes Gennedyr da Cruz Lima&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">&#201;ricka Janine Dantas da Silveira&#58; Concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Patr&#237;cia Teixeira de Oliveira&#58; Concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0085" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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          "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Perfil de express&#227;o de 8&#8208;OHdG na queilite act&#237;nica &#40;QA&#41;&#46; &#40;A&#41; Escore de imunorreatividade 1 em QA sem displasia epitelial &#40;100&#215;&#41;&#46; &#40;B&#41; Escore de imunorreatividade 2 em QA com displasia epitelial de pequeno grau&#46; Notar o predom&#237;nio da imunomarca&#231;&#227;o nuclear &#40;200&#215;&#41;&#46; &#40;C&#41; Escore de imunorreatividade 3 em QA com displasia epitelial moderada&#46; Notar o predom&#237;nio da imunomarca&#231;&#227;o nuclear &#40;200&#215;&#41;&#46; &#40;D&#41; Escore de imunorreatividade 3 em QA com displasia epitelial moderada&#46; Notar o predom&#237;nio de colora&#231;&#227;o citoplasm&#225;tica &#40;200&#215;&#41;&#46;</p>"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Branca&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">89&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Imunorreatividade da 8&#8208;OHdG</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Q25&#8208;Q75&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Descama&#231;&#227;o</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tamanho amostral&#44; mediana&#44; 25&#176; e 75&#176; quartis e signific&#226;ncia estat&#237;stica &#40;p&#41; para escore de imunorreatividade da 8&#8208;OHdG de acordo com as caracter&#237;sticas cl&#237;nicas da queilite act&#237;nica</p>"
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                0 => """
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                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;vel</th><th class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Imunorreatividade da 8&#8208;OHdG</th></tr><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Q25&#8208;Q75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Fumante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">N&#227;o fumante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;266&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Ex&#8208;fumante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#44;50&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Q25&#8208;Q75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Sem displasia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Displasia epitelial de pequeno grau&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Displasia epitelial moderada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Displasia epitelial acentuada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;50&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab3523000.png"
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Tamanho amostral&#44; mediana&#44; 25&#176; e 75&#176; quartis e signific&#226;ncia estat&#237;stica &#40;p&#41; para escore de imunorreatividade da 8&#8208;OHdG de acordo com a classifica&#231;&#227;o da OMS para displasia epitelial oral</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features and presentation of oral potentially malignant disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Warnakulasuriya"
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                        ]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.oooo.2018.03.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol&#46;"
                        "fecha" => "2018"
                        "volumen" => "125"
                        "paginaInicial" => "582"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29673799"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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            1 => array:3 [
              "identificador" => "bib0060"
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                0 => array:2 [
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Cartas ‐ Investigação
A imunoexpressão da proteína 8‐hidroxi‐2’‐desoxiguanosina está associada à patogênese da queilite actínica
Cíntia Barreto de Oliveira Varela, Cristianne Kalinne Santos Medeiros
Autor para correspondência
cristiannekalinne@gmail.com

Autor para correspondência.
, Jabes Gennedyr da Cruz Lima, Éricka Janine Dantas da Silveira, Patrícia Teixeira de Oliveira
Programa de Pós‐Graduação em Ciências Odontológicas, Departamento de Odontologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil
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          "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Perfil de express&#227;o de 8&#8208;OHdG na queilite act&#237;nica &#40;QA&#41;&#46; &#40;A&#41; Escore de imunorreatividade 1 em QA sem displasia epitelial &#40;100&#215;&#41;&#46; &#40;B&#41; Escore de imunorreatividade 2 em QA com displasia epitelial de pequeno grau&#46; Notar o predom&#237;nio da imunomarca&#231;&#227;o nuclear &#40;200&#215;&#41;&#46; &#40;C&#41; Escore de imunorreatividade 3 em QA com displasia epitelial moderada&#46; Notar o predom&#237;nio da imunomarca&#231;&#227;o nuclear &#40;200&#215;&#41;&#46; &#40;D&#41; Escore de imunorreatividade 3 em QA com displasia epitelial moderada&#46; Notar o predom&#237;nio de colora&#231;&#227;o citoplasm&#225;tica &#40;200&#215;&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A queilite act&#237;nica &#40;QA&#41; &#233; condi&#231;&#227;o inflamat&#243;ria cr&#244;nica potencialmente maligna que pode progredir para carcinoma espinocelular do l&#225;bio&#46; A radia&#231;&#227;o ultravioleta &#233; o principal fator associado ao desenvolvimento da QA&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8208;3</span></a> A exposi&#231;&#227;o cr&#244;nica &#224; radia&#231;&#227;o ultravioleta leva &#224; gera&#231;&#227;o de esp&#233;cies reativas de oxig&#234;nio que podem causar modifica&#231;&#245;es oxidativas nas bases do DNA&#44; principalmente na guanina&#44; gerando 8&#8208;hidroxi&#8208;2&#8217;&#8208;desoxiguanosina &#40;8&#8208;OHdG&#41;&#44; que pode desencadear muta&#231;&#245;es gen&#233;ticas e&#44; portanto&#44; tem sido utilizada como marcador sens&#237;vel de dano oxidativo e como fator progn&#243;stico para c&#226;ncer de pele&#44; de pulm&#227;o&#44; de es&#244;fago&#44; de mama&#44; de c&#243;lon e linfoma&#44; entre outros&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Trata&#8208;se de estudo retrospectivo&#44; descritivo e semiquantitativo da express&#227;o imuno&#8208;histoqu&#237;mica da prote&#237;na 8&#8208;OHdG no epit&#233;lio de revestimento de 57 amostras de QA&#46; O estudo foi aprovado pelo Comit&#234; de &#201;tica da Universidade Federal do Rio Grande do Norte &#40;Protocolo n&#176; 3&#46;476&#46;834&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Para o estudo morfol&#243;gico&#44; foram obtidos cortes de 5<span class="elsevierStyleHsp" style=""></span>&#956;m do material emblocado em parafina&#44; montados em l&#226;minas de vidro e corados pelo m&#233;todo da hematoxilina &#38; eosina&#46; Os cortes histol&#243;gicos foram examinados e classificados como sem ou com displasia epitelial que foi graduada como displasia leve&#44; moderada ou grave de acordo com os crit&#233;rios morfol&#243;gicos da Organiza&#231;&#227;o Mundial da Sa&#250;de &#40;OMS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Para a an&#225;lise imuno&#8208;histoqu&#237;mica&#44; o material tratado com o anticorpo anti&#8208;8&#8208;OHdG &#40;Santa Cruz Biotechnology Cat&#35; sc&#8208;66036&#44; RRID&#58; AB 832272&#41; foi examinado por dois avaliadores previamente calibrados e cegados&#46; A an&#225;lise foi realizada por microscopia &#243;ptica nos aumentos de 100&#215; e 400&#215; no componente epitelial em toda a les&#227;o&#44; cuja extens&#227;o foi determinada pela &#225;rea de elastose solar no tecido conjuntivo e por altera&#231;&#245;es epiteliais&#44; se presentes&#46; Os casos foram categorizados com base em escore de imunorreatividade&#46; Para esse prop&#243;sito&#44; a intensidade da colora&#231;&#227;o foi avaliada primeiramente no epit&#233;lio e classificada da seguinte maneira&#58; 0 &#40;negativa&#41;&#44; 1 &#40;fraca&#41;&#44; 2 &#40;moderada&#41; e 3 &#40;forte&#41;&#46; Foi considerada a intensidade predominante em cada caso&#46; A imunomarca&#231;&#227;o foi analisada semiquantitativamente&#44; atribuindo&#8208;se os seguintes escores&#58; 0 &#40;negativo&#41;&#44; 1 &#40;1&#37; a 50&#37; de c&#233;lulas positivas&#41; e 2 &#40;51&#37; a 100&#37; de c&#233;lulas positivas&#41;&#46; As c&#233;lulas epiteliais que exibiam colora&#231;&#227;o marrom no n&#250;cleo e&#47;ou citoplasma foram classificadas como positivas&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;7</span></a> O escore de imunorreatividade foi ent&#227;o calculado multiplicando&#8208;se o escore de intensidade da colora&#231;&#227;o pelo escore da porcentagem de c&#233;lulas positivas&#46; O escore final de cada caso variou de 0 a 6&#44; em que 0&#8208;2 &#61; imunorreatividade fraca&#44; 3&#8208;4 &#61; imunorreatividade moderada e 5&#8208;6<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>imunorreatividade forte&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Houve predom&#237;nio de pacientes do sexo masculino &#40;72&#44;2&#37;&#41; e brancos &#40;64&#44;9&#37;&#41;&#44; n&#227;o fumantes ou ex&#8208;fumantes &#40;49&#44;2&#37;&#41;&#44; com idade igual ou superior a 40 anos &#40;93&#37;&#41; e com hist&#243;ria de exposi&#231;&#227;o cr&#244;nica &#224; radia&#231;&#227;o ultravioleta &#40;66&#44;7&#37;&#41;&#46; Manchas brancas foram a caracter&#237;stica cl&#237;nica mais frequente nos casos estudados &#40;56&#44;1&#37;&#41;&#44; seguidas de placa branca e descama&#231;&#227;o&#59; ulcera&#231;&#227;o foi menos comum &#40;10&#44;5&#37;&#59; <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Imunomarca&#231;&#227;o nas c&#233;lulas epiteliais foi observada em 100&#37; dos casos analisados&#44; principalmente nas camadas basal e parabasal do epit&#233;lio&#46; A imunomarca&#231;&#227;o foi predominantemente nuclear com colora&#231;&#227;o citoplasm&#225;tica de pequena intensidade em 39&#44;6&#37; dos casos e colora&#231;&#227;o predominantemente citoplasm&#225;tica em 12&#44;1&#37;&#44; enquanto a mesma intensidade foi observada no n&#250;cleo e citoplasma de 48&#44;3&#37; dos casos&#46; Forte imunorreatividade ao anticorpo foi detectada em 64&#44;9&#37; dos casos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; A imunomarca&#231;&#227;o no n&#250;cleo e no citoplasma pode ser explicada pelo fato de que 8&#8208;OHdG &#233; encontrada tanto no DNA nuclear quanto no mitocondrial&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#44;9</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">O estresse oxidativo no DNA estava presente independentemente das caracter&#237;sticas cl&#237;nicas das les&#245;es&#46; N&#227;o foram encontradas diferen&#231;as estatisticamente significantes na express&#227;o de 8&#8208;OHdG de acordo com as caracter&#237;sticas cl&#237;nicas das les&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41; ou presen&#231;a de tabagismo &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;266&#59; <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46; Prabhulkar e Li monitoraram a cin&#233;tica de libera&#231;&#227;o de 8&#8208;OhdG na superf&#237;cie de uma c&#233;lula epitelial pulmonar exposta &#224; nicotina para avaliar o dano oxidativo causado pelo tabaco&#59; os autores observaram que quanto maior o n&#237;vel de exposi&#231;&#227;o celular &#224; nicotina&#44; maior o dano oxidativo ao DNA&#44; promovendo aumento no n&#237;vel de 8&#8208;OhdG secretada pela c&#233;lula&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Nas amostras do presente estudo&#44; foram observados danos oxidativos ao DNA demonstrados pela presen&#231;a de 8&#8208;OhdG&#44; independentemente da exposi&#231;&#227;o dos indiv&#237;duos ao tabaco&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">A classifica&#231;&#227;o histopatol&#243;gica revelou algum grau de displasia epitelial em 87&#44;7&#37; dos casos&#46; Displasia epitelial de pequeno grau foi a mais comum &#40;38&#44;6&#37;&#41;&#44; seguida pela displasia epitelial moderada &#40;29&#44;8&#37;&#41; e acentuada &#40;19&#44;3&#37;&#41;&#46; Displasia epitelial esteve ausente em 12&#44;3&#37; dos casos&#46; Forte imunorreatividade foi observada na maioria dos casos&#44; independentemente da presen&#231;a de displasia epitelial ou de seu grau&#46; N&#227;o foi observada diferen&#231;a significante na express&#227;o de 8&#8208;OhdG entre os diferentes graus de displasia epitelial oral &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;225&#59; <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46; De maneira similar&#44; Yoshifuku et al&#46; tamb&#233;m encontraram predomin&#226;ncia de forte imunorreatividade com 8OHdG em les&#245;es de ceratose act&#237;nica &#40;presen&#231;a de displasia epitelial de pequeno grau ou moderada&#41; e doen&#231;a de Bowen &#40;displasia epitelial acentuada&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Esses achados podem ser explicados pelo fato de que a exposi&#231;&#227;o cr&#244;nica &#224; radia&#231;&#227;o ultravioleta desencadeia a produ&#231;&#227;o cont&#237;nua de esp&#233;cies reativas de oxig&#234;nio e estresse oxidativo e&#44; consequentemente&#44; a forma&#231;&#227;o constante de 8&#8208;OHdG&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Embora a express&#227;o de 8&#8208;OHdG seja &#250;til para a avalia&#231;&#227;o do dano oxidativo ao DNA e esteja bem estabelecida como indicador progn&#243;stico em diferentes tipos de c&#226;ncer&#44; com evid&#234;ncias sugerindo que o dano oxidativo ao DNA por meio da forma&#231;&#227;o de 8&#8208;OHdG est&#225; envolvido na patog&#234;nese e progress&#227;o do carcinoma espinocelular&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8&#44;10</span></a> os presentes resultados apontam para dificuldades na utiliza&#231;&#227;o desse marcador para estabelecer associa&#231;&#227;o com caracter&#237;sticas clinicodemogr&#225;ficas e com o grau morfol&#243;gico da queilite act&#237;nica&#44; uma vez que a 8&#8208;OHdG foi expressa de modo marcante na maioria dos casos analisados&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Os resultados do presente estudo confirmam que o estresse oxidativo por danos ao DNA desempenha papel na queilite act&#237;nica&#44; como sugerido pela forte express&#227;o imuno&#8208;histoqu&#237;mica de 8&#8208;OHdG nos casos analisados&#46; Entretanto&#44; a falta de diferen&#231;a significante na imunorreatividade anti&#8208;8&#8208;OHdG entre diferentes graus de displasia epitelial oral e fatores clinicodemogr&#225;ficos demonstra que esse marcador est&#225; alterado independentemente das caracter&#237;sticas cl&#237;nicas e do grau de displasia epitelial&#44; e as modifica&#231;&#245;es oxidativas da base do DNA s&#227;o um evento inicial na carcinog&#234;nese labial&#46; Assim&#44; tratamentos medicamentosos adjuvantes que minimizem os danos causados pelo estresse oxidativo&#44; como agentes antioxidantes t&#243;picos&#44; podem ser medidas terap&#234;uticas &#250;teis em pacientes com queilite act&#237;nica&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0055" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0060" class="elsevierStylePara elsevierViewall">C&#237;ntia Barreto de Oliveira Varela&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Cristianne Kalinne Santos Medeiros&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; an&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Jabes Gennedyr da Cruz Lima&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">&#201;ricka Janine Dantas da Silveira&#58; Concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Patr&#237;cia Teixeira de Oliveira&#58; Concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0085" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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          "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Perfil de express&#227;o de 8&#8208;OHdG na queilite act&#237;nica &#40;QA&#41;&#46; &#40;A&#41; Escore de imunorreatividade 1 em QA sem displasia epitelial &#40;100&#215;&#41;&#46; &#40;B&#41; Escore de imunorreatividade 2 em QA com displasia epitelial de pequeno grau&#46; Notar o predom&#237;nio da imunomarca&#231;&#227;o nuclear &#40;200&#215;&#41;&#46; &#40;C&#41; Escore de imunorreatividade 3 em QA com displasia epitelial moderada&#46; Notar o predom&#237;nio da imunomarca&#231;&#227;o nuclear &#40;200&#215;&#41;&#46; &#40;D&#41; Escore de imunorreatividade 3 em QA com displasia epitelial moderada&#46; Notar o predom&#237;nio de colora&#231;&#227;o citoplasm&#225;tica &#40;200&#215;&#41;&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Imunorreatividade da 8&#8208;OHdG</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Q25&#8208;Q75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sem displasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Displasia epitelial de pequeno grau&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Displasia epitelial moderada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Displasia epitelial acentuada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;50&#8208;3&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Tamanho amostral&#44; mediana&#44; 25&#176; e 75&#176; quartis e signific&#226;ncia estat&#237;stica &#40;p&#41; para escore de imunorreatividade da 8&#8208;OHdG de acordo com a classifica&#231;&#227;o da OMS para displasia epitelial oral</p>"
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    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
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Informação do artigo
ISSN: 26662752
Idioma original: Português
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Anais Brasileiros de Dermatologia (Portuguese)
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