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Aproximadamente&#44; 1&#44;5 a 2&#44;0 milh&#245;es e 500&#46;000 novos casos de CL e LV&#44; respectivamente&#44; s&#227;o observados anualmente&#46; A leishmaniose causa cerca de 40 mil mortes por ano<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">3</span></a> e &#233; influenciada por diversos fatores&#44; como origem gen&#233;tica do hospedeiro&#44; aspectos nutricionais&#44; <span class="elsevierStyleItalic">Leishmania</span> spp&#46;&#44; meio ambiente e aspecto imunol&#243;gico&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">4</span></a> Um estudo recente relatou que as varia&#231;&#245;es gen&#233;ticas do hospedeiro podem desempenhar papel fundamental na suscetibilidade &#224; leishmaniose&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">5</span></a> Muitos genes foram investigados&#44; evidenciando forte rela&#231;&#227;o entre SNPs e risco de desenvolver leishmaniose&#44; incluindo interferon&#8208;gama &#40;IFN&#8208;G&#41;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">6</span></a> e interleucina&#8208;6 &#40;IL&#8208;6&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A lectina de liga&#231;&#227;o &#224; manose &#40;MBL&#41; &#233; um receptor de reconhecimento de pat&#243;genos &#40;PRR&#41; e desempenha papel cr&#237;tico na imunidade do hospedeiro&#46; A MBL leva &#224; ativa&#231;&#227;o do sistema complemento&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">8&#44;9</span></a> Essa prote&#237;na oligom&#233;rica consiste em subunidades estruturais formadas por tr&#234;s polipept&#237;dios id&#234;nticos de 32 kD&#44; cada um contendo uma liga&#231;&#227;o cruzada com a regi&#227;o N&#8208;terminal da ciste&#237;na&#44; col&#225;geno ligado &#224; regi&#227;o do pesco&#231;o e uma regi&#227;o do dom&#237;nio C&#8208;terminal que reconhece carboidratos em microrganismos&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Por meio de m&#250;ltiplos dom&#237;nios da lectina&#44; carboidratos como manose &#40;carboidratos de seis carbonos&#41; s&#227;o encontrados na superf&#237;cie de v&#225;rios pat&#243;genos&#44; incluindo <span class="elsevierStyleItalic">Trypanosoma cruzi</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">11</span></a><span class="elsevierStyleItalic">Plasmodium falciparum</span><a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a> e <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">13</span></a> Ap&#243;s o reconhecimento dessas mol&#233;culas pela lectina&#44; as serina proteases s&#227;o ativadas para facilitar a opsoniza&#231;&#227;o &#40;fagocitose&#41; pelos macr&#243;fagos e a lise da superf&#237;cie do microrganismo&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">14</span></a> A forma infecciosa da leishmania &#40;promastigota&#41; &#233; caracterizada pela presen&#231;a de lipofosfoglicanos &#40;GLP&#41; e outras mol&#233;culas como a manose&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">15&#44;16</span></a> Esses componentes atuam como padr&#245;es moleculares associados a pat&#243;genos &#40;PAMPs&#41; que s&#227;o reconhecidos pelos componentes do complemento&#46;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">O gene <span class="elsevierStyleItalic">MBL2</span> est&#225; localizado no cromossomo 10 &#40;10q11&#46;2&#8208;q21&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">19</span></a> Nesse gene&#44; v&#225;rios SNPs foram identificados&#44; os quais s&#227;o conhecidos por seu efeito funcional que influencia o desenvolvimento de doen&#231;as infecciosas&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">20&#8211;22</span></a> Os SNPs funcionais&#44; localizados na regi&#227;o do promotor&#44; como o SNP &#8208;550 H&#47;L &#40;substitui&#231;&#227;o de G<span class="elsevierStyleHsp" style=""></span>&#62; C&#44; rs11003125&#41;&#44; &#8208;221 X&#47;Y &#40;substitui&#231;&#227;o de C<span class="elsevierStyleHsp" style=""></span>&#62; G&#44; rs7096206&#41; e &#43;4 Q&#47;P &#40;A substitui&#231;&#227;o de C<span class="elsevierStyleHsp" style=""></span>&#62; T&#44; rs7095891&#41; localizada na regi&#227;o n&#227;o traduzida&#44; pode regular a taxa de transcri&#231;&#227;o do gene&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">23</span></a> No primeiro &#233;xon existem tr&#234;s SNPs localizados no c&#243;don 52 CGT<span class="elsevierStyleHsp" style=""></span>&#62; TGT &#40;rs5030737&#41;&#44; c&#243;don 54 GGC<span class="elsevierStyleHsp" style=""></span>&#62; GAC &#40;rs1800450&#41; e c&#243;don 57 GGA<span class="elsevierStyleHsp" style=""></span>&#62; GAA &#40;rs1800451&#41;&#44; correspondendo a altera&#231;&#245;es de amino&#225;cidos entre arginina para ciste&#237;na &#40;Arg52Cys&#44; alelo D&#41;&#44; glicina para &#225;cido asp&#225;rtico &#40;Gly54Asp&#44; alelo B&#41; e glicina para &#225;cido glut&#226;mico &#40;Gly57Glu&#44; alelo C&#41; na regi&#227;o col&#225;gena da cadeia polipept&#237;dica&#44; respectivamente&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">24</span></a> Esses tr&#234;s polimorfismos formam o sistema AO&#44; no qual o alelo selvagem &#233; descrito como o alelo A&#44; e o alelo O como um mutante&#46; O gen&#243;tipo A&#47;O est&#225; correlacionado com baixos n&#237;veis da prote&#237;na e indetect&#225;vel para o gen&#243;tipo O&#47;O&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">25</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Resultados conflitantes s&#227;o observados entre as variantes do gene MBL2 e a suscetibilidade &#224; leishmaniose&#46; Variantes&#44; caracterizando altos n&#237;veis da prote&#237;na&#44; foram associadas &#224; suscetibilidade &#224; LV na &#193;frica&#44;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">26</span></a> no nordeste do Brasil<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">27</span></a> e na &#205;ndia&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">28</span></a> No entanto&#44; um estudo realizado em indiv&#237;duos com CL no norte do Amazonas mostrou que todos os polimorfismos relacionados a baixos n&#237;veis de MBL tiveram uma forte associa&#231;&#227;o com a susceptibilidade&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Alguns estudos foram conduzidos anteriormente para avaliar os efeitos dos polimorfismos do gene MBL2 no progresso da infec&#231;&#227;o em leishmaniose&#44; com resultados contradit&#243;rios&#44; em virtude do pequeno tamanho de amostra&#44; que carece de poder adequado para detectar os efeitos dos polimorfismos do gene <span class="elsevierStyleItalic">MBL2</span> na leishmaniose&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">At&#233; o momento&#44; nenhuma revis&#227;o sistem&#225;tica foi realizada com variantes do gene <span class="elsevierStyleItalic">MBL2</span> e leishmaniose&#46; O uso da metan&#225;lise como ferramenta estat&#237;stica que explora os fatores de risco associados a diferentes doen&#231;as gen&#233;ticas pode fornecer uma conclus&#227;o confi&#225;vel&#46; Esta revis&#227;o sistem&#225;tica incluiu estudos de caso&#8208;controle de associa&#231;&#227;o gen&#233;tica de variantes &#40;rs11003125&#44; rs7096206&#44; rs7095891&#44; rs5030737&#44; rs1800450 e rs1800451&#41; no gene <span class="elsevierStyleItalic">MBL2</span> e risco de desenvolver leishmaniose&#46; Esta revis&#227;o sistem&#225;tica est&#225; no registro internacional prospectivo de revis&#245;es sistem&#225;ticas &#40;PROSPERO&#41;&#58; CRD42020201755&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Materiais e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Pesquisa de banco de dados</span><p id="par0040" class="elsevierStylePara elsevierViewall">Esta revis&#227;o sistem&#225;tica foi conduzida de acordo com as recomenda&#231;&#245;es do protocolo PRISMA &#40;<span class="elsevierStyleItalic">Preferred Reporting Items for Systematic reviews and Meta&#8208;Analyzes</span>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">30</span></a> PubMed&#44; Science Direct&#44; Cochrane Library&#44; Scopus e Lilacs foram pesquisados at&#233; dezembro de 2019 por tr&#234;s revisores independentes&#44; sem restri&#231;&#227;o de idioma ou tempo&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Foi usada a estrat&#233;gia&#58; P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>pacientes sob risco de leishmaniose&#59; I<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>presen&#231;a de polimorfismos&#59; C<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>aus&#234;ncia de polimorfismos&#59; O<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>ocorr&#234;ncia de leishmaniose&#46; Os seguintes termos de pesquisa foram usados&#58; &#40;&#8220;Leishmaniasis&#8221; OR &#8220;Cutaneous Leishmaniasis&#8221; OR &#8220;Visceral Leishmaniasis&#8221; OR &#8220;Leishmania Infection&#8221; OR &#8220;Leishmania Infections&#8221;&#41; AND &#40;&#8220;Mannose&#8208;binding Lectin&#8221; OR &#8220;Mannose&#8208;binding Lectin 2&#8221; OR &#8220;MBL&#8221; OR &#8220;MBL2&#8221;&#41; AND &#40;&#8220;Polymorphism&#8221; OR &#8220;Polymorphisms&#8221; OR &#8220;Single Nucleotide Polymorphism&#8221; OR &#8220;Single Nucleotide Polymorphisms&#8221;&#41;&#46; As refer&#234;ncias citadas em artigos eleg&#237;veis foram pesquisadas manualmente para identificar publica&#231;&#245;es adicionais&#46; A aprova&#231;&#227;o &#233;tica e o consentimento informado n&#227;o foram necess&#225;rios&#44; uma vez que este estudo foi baseado em estudos publicados anteriormente e n&#227;o teve contato direto com o paciente ou influ&#234;ncias no atendimento ao paciente&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Sele&#231;&#227;o de estudos</span><p id="par0050" class="elsevierStylePara elsevierViewall">Dois pesquisadores avaliaram independentemente todos os resultados da pesquisa&#46; Os crit&#233;rios de inclus&#227;o foram os seguintes&#58; 1&#41; estudo caso&#8208;controle&#44; 2&#41; rs11003125 &#40;&#8208;550&#41;&#44; rs7096206 &#40;&#8208;221&#41;&#44; rs7095891 &#40;&#43;4&#41;&#44; rs5030737 &#40;c&#243;don 52&#41;&#44; rs1800450 &#40;CD54&#41; e rs1800451 &#40;CD57&#41; polimorfismos&#44; 3&#41; estudos com dados de genotipagem suficientemente dispon&#237;veis para o c&#225;lculo dos <span class="elsevierStyleItalic">Odds Ratios</span> &#40;OR&#41; com Intervalos de Confian&#231;a de 95&#37; &#40;95&#37; IC&#41; e 4&#41; o Equil&#237;brio de Hardy&#8208;Weinberg &#40;HWE&#41;&#46; Os crit&#233;rios de exclus&#227;o foram&#58; 1&#41; estudo n&#227;o caso&#8208;controle&#44; 2&#41; relatos de caso&#44; 3&#41; revis&#245;es&#44; 4&#41; estudos em animais&#44; 5&#41; editoriais&#44; 6&#41; estudos sem dados dispon&#237;veis&#44; 7&#41; estudos com metan&#225;lise&#44; 8&#41; outros polimorfismos e 9&#41; dados duplicados&#46; Posteriormente&#44; todos os artigos selecionados foram checados por um terceiro pesquisador&#44; que resolveu as diverg&#234;ncias&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Extra&#231;&#227;o de dados</span><p id="par0055" class="elsevierStylePara elsevierViewall">Dois pesquisadores extra&#237;ram independentemente os seguintes dados dos estudos inclu&#237;dos&#58; ano de publica&#231;&#227;o&#44; primeiro autor&#44; regi&#227;o do estudo&#44; grupo &#233;tnico&#44; forma cl&#237;nica&#44; n&#250;mero de amostras&#44; idade e SNPs estudados&#46; As diverg&#234;ncias entre os pesquisadores foram discutidas e resolvidas pela consulta a um terceiro pesquisador&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Avalia&#231;&#227;o de pontua&#231;&#227;o de qualidade</span><p id="par0060" class="elsevierStylePara elsevierViewall">A escala <span class="elsevierStyleItalic">Newcastle&#8208;Ottawa</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41; foi usada para avaliar a qualidade dos estudos eleg&#237;veis&#46; Usando esse sistema&#44; cada estudo inclu&#237;do foi submetido a tr&#234;s julgamentos&#58; 1&#41; sele&#231;&#227;o de grupos de estudo&#59; 2&#41; comparabilidade dos grupos e 3&#41; resultado de interesse &#40;caso&#8208;controle&#41;&#46; Tr&#234;s pesquisadores calcularam independentemente a pontua&#231;&#227;o de cada publica&#231;&#227;o&#46; Os escores variaram de 0 a 9&#46; Os estudos com escore<span class="elsevierStyleHsp" style=""></span>&#62; 6 foram considerados de alta qualidade&#44; enquanto escore &#60; 6&#44; de baixa qualidade&#46; As diverg&#234;ncias entre os pesquisadores foram discutidas em grupo e resolvidas em consenso&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lise estat&#237;stica</span><p id="par0065" class="elsevierStylePara elsevierViewall">A metan&#225;lise avaliou a associa&#231;&#227;o do gene MBL2 e leishmaniose sob o modelo gen&#233;tico al&#233;lico&#44; &#8208;550 &#40;H <span class="elsevierStyleItalic">vs</span>&#46; L&#41;&#44; &#8208;221 &#40;X <span class="elsevierStyleItalic">vs</span>&#46; Y&#41;&#44; &#43;4 &#40;Q <span class="elsevierStyleItalic">vs</span>&#46; P&#41;&#44; CD52 &#40;A <span class="elsevierStyleItalic">vs</span>&#46; D&#41;&#44; CD54 &#40;A <span class="elsevierStyleItalic">vs</span>&#46; B&#41;&#44; CD57 &#40;A <span class="elsevierStyleItalic">vs</span>&#46; C&#41; e gen&#243;tipo A&#47;O &#40;A <span class="elsevierStyleItalic">vs</span>&#46; O&#41;&#46; O I<span class="elsevierStyleSup">2</span> foi utilizado para avaliar a heterogeneidade entre os estudos onde os valores 25&#37;&#44; 50&#37; e 75&#37; corresponderam a baixa&#44; moderada e alta heterogeneidade&#44; respectivamente&#46; O modelo fixo foi usado quando I<span class="elsevierStyleSup">2</span> &#60;<span class="elsevierStyleHsp" style=""></span>50&#37;&#44; e o modelo aleat&#243;rio foi usado quando I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#62; 50&#37;&#46; OR agrupados foram calculados usando o Mantel&#8208;Haenszel&#44; e a signific&#226;ncia estat&#237;stica de OR foi determinada usando estat&#237;stica Z&#46; Em ambos os modelos&#44; o valor p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005 foi considerado estatisticamente significativo&#46; O <span class="elsevierStyleItalic">software</span> RStudio &#40;<a href="http://www.rstudio.com/products/rstudio/">www&#46;rstudio&#46;com&#47;products&#47;rstudio&#47;</a>&#41;&#44; vers&#227;o 1&#46;3&#46;1 para Windows foi usado como programa estat&#237;stico para o estudo&#46; Pacotes &#40;&#8220;<span class="elsevierStyleItalic">tidyverse</span>&#8221;&#41;&#44; &#40;&#8220;meta&#8221;&#41;&#44; &#40;&#8220;<span class="elsevierStyleItalic">metafor</span>&#8221;&#41;&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Caracter&#237;sticas dos estudos inclu&#237;dos</span><p id="par0070" class="elsevierStylePara elsevierViewall">Foram pulicados 389 artigos identificados usando as bases de dados da literatura cient&#237;fica &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Dentre os artigos selecionados&#44; 35 foram removidos por duplica&#231;&#227;o&#44; 349 artigos foram exclu&#237;dos por n&#227;o atenderem aos crit&#233;rios de inclus&#227;o&#46; Por fim&#44; apenas quatro artigos&#44;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">26&#8211;29</span></a> respeitando os crit&#233;rios obrigat&#243;rios&#44; foram inclu&#237;dos na metan&#225;lise&#46; Esses estudos foram publicados em ingl&#234;s entre 2007 e 2015 &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Um estudo foi realizado em crian&#231;as africanas&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">26</span></a> Outros dois estudos foram de popula&#231;&#245;es mistas do Nordeste do Brasil&#44; compostas por 21&#37; de europeus&#44; 31&#37; de africanos e 48&#37; de ancestrais nativos americanos&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">27</span></a> e do norte do Brasil &#40;estado do Amazonas&#41;&#44; com uma popula&#231;&#227;o mista de 10&#37; de africanos&#44; 40&#37; ancestrais europeus e 50&#37; dos nativos americanos&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a> O quarto estudo foi realizado na &#205;ndia&#44; mas n&#227;o especificou a etnia dos indiv&#237;duos estudados&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">28</span></a> Tr&#234;s estudos analisaram pacientes com LV<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">26&#8211;28</span></a> e um analisou pacientes com CL&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a><span class="elsevierStyleItalic">Leishmania</span> spp&#46; identificadas foram&#58; <span class="elsevierStyleItalic">L&#46; chagasi</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">27</span></a><span class="elsevierStyleItalic">L&#46; infantum</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">26</span></a><span class="elsevierStyleItalic">L&#46; guyanensis</span><a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a> e <span class="elsevierStyleItalic">L&#46; donovani</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">28</span></a> Um estudo analisou todos os polimorfismos alvo desta metan&#225;lise&#44;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a> enquanto outro apenas cinco SNPs &#40;rs11003125&#44; rs7096206&#44; rs5030737&#44; rs1800450 e rs1800451&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">27</span></a> Um estudo analisou tr&#234;s SNPs &#40;rs7096206&#44; rs1800450 e rs1800451&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">26</span></a> e o estudo restante apenas um SNP &#40;rs7095891&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">28</span></a> Dois estudos forneceram dados suficientes para realizar a an&#225;lise do sistema A&#47;O&#46;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">27&#44;29</span></a> Um total de 1&#46;758 pessoas participaram desses estudos &#40;791 pacientes e 967 controles&#41;&#46; De acordo com a escala de Newcastle&#8208;Ottawa&#44; dois estudos obtiveram 9 pontos e dois com 8 pontos &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; A frequ&#234;ncia dos gen&#243;tipos e alelos est&#227;o organizados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Metan&#225;lise</span><p id="par0080" class="elsevierStylePara elsevierViewall">Os resultados da metan&#225;lise s&#227;o mostrados na <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>&#46; Nenhuma das an&#225;lises para qualquer modelo gen&#233;tico de alelo para as duas variantes &#40;&#8208;550 e &#8208;221&#41; no promotor e as variantes &#43;4 na regi&#227;o n&#227;o traduzida mostraram associa&#231;&#227;o com suscetibilidade ou resist&#234;ncia &#224; leishmaniose &#40;o alelo &#8208;550H&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;92&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;76&#8208;1&#44;12&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;93&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37; e alelo &#8208;550L&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;08&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;89&#8208;1&#44;32&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;93&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41;&#44; o alelo &#8208;221X&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;98&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;45&#8208;2&#44;13&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>91&#37; e alelo &#8208;221Y&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;02&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;47&#8208;2&#44;22&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>91&#37;&#41; e o alelo Q &#43;4&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;85&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;54&#8208;1&#44;33&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>79&#37; e alelo P&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;17&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;75&#8208;1&#44;84&#59;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>79&#37;&#41;&#46; Resultados semelhantes foram obtidos para variantes localizadas no exon 1 CD52 &#40;alelo A do alelo&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;13&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;68&#8208;1&#44;87&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;87&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37; e alelo D do alelo&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;89&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;53&#8208;1&#44;47&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;87&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#37;&#41;&#44; CD54 &#40;alelo A&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;04&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;62&#8208;1&#44;75&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>79&#37; e alelo B&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;96&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;57&#8208;1&#44;61&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>79&#37;&#41; e CD57 &#40;alelo A&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;85&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;44&#8208;1&#44;62&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>72&#37; e alelo C&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;18&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;62&#8208;2&#44;26&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>72&#37;&#41;&#46; A presen&#231;a do alelo A selvagem &#40;alelo A&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;05&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;39&#8208;2&#44;81&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>94&#37;&#41; e alelo O mutante &#40;alelo O&#58; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;95&#59; 95&#37; IC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;36&#8208;2&#44;56&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#59; I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>94&#37;&#41; tamb&#233;m n&#227;o foram associados &#224; suscetibilidade ou resist&#234;ncia&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discuss&#227;o</span><p id="par0085" class="elsevierStylePara elsevierViewall">A MBL reconhece a presen&#231;a de manose na superf&#237;cie dos pat&#243;genos para promover a opsoniza&#231;&#227;o e a ativa&#231;&#227;o do sistema complemento&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">31</span></a> A MBL desempenha papel fundamental na resposta imune inata&#44;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">32</span></a> destacando sua concentra&#231;&#227;o s&#233;rica como requisito para a predisposi&#231;&#227;o ao desenvolvimento de doen&#231;as infecciosas humanas&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">33&#44;34</span></a> As variantes do gene <span class="elsevierStyleItalic">MBL2</span> foram associadas a risco aumentado de infec&#231;&#227;o por protozo&#225;rios&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">35&#44;36</span></a> No entanto&#44; poucos estudos investigaram variantes gen&#233;ticas no gene <span class="elsevierStyleItalic">MBL2</span> na infec&#231;&#227;o por leishmania&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">26&#8211;29</span></a> Tr&#234;s estudos sugeriram que as variantes correlacionadas com baixos n&#237;veis circulantes de MBL s&#227;o protetoras para VL&#44;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">26&#44;28</span></a> enquanto um estudo mostrou suscetibilidade ao CL&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Os resultados conflitantes gerados pela maioria dos estudos tiveram um poder estat&#237;stico fraco em virtude do pequeno tamanho da amostra inclu&#237;da&#46; Para esclarecer resultados contradit&#243;rios em estudos de associa&#231;&#227;o gen&#233;tica&#44; a metan&#225;lise oferece um m&#233;todo poderoso para sintetizar dados obtidos de estudos independentes&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">37</span></a> Para abordar as limita&#231;&#245;es dos estudos de caso&#8208;controle&#44; a presente metan&#225;lise foi realizada para fornecer evid&#234;ncias estat&#237;sticas da associa&#231;&#227;o entre os polimorfismos do gene <span class="elsevierStyleItalic">MBL2</span> e a suscetibilidade &#224; leishmaniose com ORs agrupados&#46; At&#233; o momento&#44; esta &#233; a primeira metan&#225;lise que aborda a associa&#231;&#227;o entre os polimorfismos descritos e a leishmaniose&#46; Metan&#225;lises anteriores sugeriram uma associa&#231;&#227;o de polimorfismos nos genes IL2RA &#40;receptor alfa da interleucina 2&#41;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">38</span></a> e SLC11A1 &#40;fam&#237;lia transportadora de soluto 11 <span class="elsevierStyleItalic">member</span> a1&#41;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">39</span></a> com os aspectos cl&#237;nicos da leishmaniose&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Neste estudo&#44; os dados de quatro artigos foram analisados de acordo com os alelos de baixa e alta produ&#231;&#227;o da MBL&#46; No entanto&#44; as an&#225;lises de metan&#225;lise n&#227;o mostraram associa&#231;&#227;o entre os alelos do gene <span class="elsevierStyleItalic">MBL2</span> e a suscetibilidade &#224; leishmaniose &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Alta heterogenicidade foi observada para as variantes&#58; &#8208;550 H&#47;L &#40;91&#37;&#41;&#44; &#43;4 Q&#47;P &#40;79&#37;&#41;&#44; CD54 A&#47;B &#40;79&#37;&#41;&#44; CD57 A&#47;C &#40;72&#37;&#41; e A&#47;O &#40;94&#37;&#41;&#46; Isso pode ser explicado principalmente pelo fato de haver miscigena&#231;&#227;o &#233;tnica nos indiv&#237;duos dos estudos selecionados&#46; Tr&#234;s estudos investigaram pacientes com VL&#44;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">26&#8211;28</span></a> e um paciente investigado com LC&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a> Em cada estudo&#44; a esp&#233;cie do agente etiol&#243;gico foi diferente&#46; &#201; importante notar que o valor da heterogeneidade influencia o modelo estat&#237;stico adequado&#46; Estudos com pequenos tamanhos de amostra podem mostrar resultados n&#227;o confi&#225;veis&#46; Como consequ&#234;ncia&#44; o modelo aleat&#243;rio deve ser sempre aplicado&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">40</span></a> Dentre os estudos selecionados&#44; um analisou todos os seis polimorfismos alvo&#44; os dipl&#243;tipos&#44; e tamb&#233;m os hapl&#243;tipos&#44;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">29</span></a> com um n&#250;mero amostral elevado&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">No entanto&#44; deve&#8208;se ter cautela na interpreta&#231;&#227;o desses resultados&#44; pois se baseiam em poucos estudos&#44; os quais apresentam resultados divergentes quando analisados separadamente&#46; Portanto&#44; mais estudos s&#227;o necess&#225;rios para confirmar se as variantes que determinam os n&#237;veis s&#233;ricos baixos s&#227;o suscet&#237;veis ou protetoras&#46; Ressaltamos a import&#226;ncia do estudo de associa&#231;&#227;o envolvendo marcadores gen&#233;ticos na leishmaniose&#44; para novos entendimentos sobre os mecanismos moleculares da doen&#231;a&#46; As variantes podem ser utilizadas como marcadores moleculares da predisposi&#231;&#227;o do indiv&#237;duo a certos tipos de doen&#231;as ou como alvos terap&#234;uticos no desenvolvimento de novos medicamentos&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conclus&#227;o</span><p id="par0105" class="elsevierStylePara elsevierViewall">Esta metan&#225;lise n&#227;o mostrou associa&#231;&#227;o significativa entre os polimorfismos rs11003125&#44; rs7096206&#44; rs7095891&#44; rs5030737&#44; rs1800450 e rs1800451 do gene <span class="elsevierStyleItalic">MBL2</span> e leishmaniose&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Suporte financeiro</span><p id="par0110" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Contribui&#231;&#227;o dos autores</span><p id="par0115" class="elsevierStylePara elsevierViewall">Wonei de Seixas Vital&#58; Conceitua&#231;&#227;o&#59; an&#225;lise formal&#59; metodologia&#59; supervis&#227;o&#59; valida&#231;&#227;o&#59; reda&#231;&#227;o &#8211; revis&#227;o e edi&#231;&#227;o&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Felipe Jules de Ara&#250;jo Santos&#58; Conceitua&#231;&#227;o&#59; an&#225;lise formal&#59; metodologia&#59; supervis&#227;o&#59; valida&#231;&#227;o&#59; reda&#231;&#227;o &#8211; revis&#227;o e edi&#231;&#227;o&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Maur&#237;cio Leandro Fernandes Gon&#231;alves&#58; Curadoria de dados&#59; an&#225;lise formal&#59; metodologia&#59; reda&#231;&#227;o &#8211; rascunho original&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Claudia Dantas Comandolli Wyrepkowski&#58; Curadoria de dados&#59; an&#225;lise formal&#59; metodologia&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Rajendranath Ramasawmy&#58; Curadoria de dados&#59; an&#225;lise formal&#59; metodologia&#59; reda&#231;&#227;o&#59; revis&#227;o final&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Silvania da Concei&#231;&#227;o Furtado&#58; Conceitua&#231;&#227;o&#59; an&#225;lise formal&#59; metodologia&#59; supervis&#227;o&#59; valida&#231;&#227;o&#59; reda&#231;&#227;o &#8211; revis&#227;o e edi&#231;&#227;o&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflito de interesses</span><p id="par0145" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A leishmaniose &#233; causada por um protozo&#225;rio intracelular do g&#234;nero <span class="elsevierStyleItalic">Leishmania</span>&#46; Lectina ligante de manose &#40;MBL&#41; &#233; uma prote&#237;na do complemento do soro e reconhece ant&#237;genos lipoproteicos nos protozo&#225;rios e na membrana plasm&#225;tica da bact&#233;ria&#46; Variantes de nucleot&#237;deos na regi&#227;o promotora e &#233;xon 1 do gene <span class="elsevierStyleItalic">MBL</span> podem influenciar sua express&#227;o ou alterar sua estrutura molecular&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar por meio de revis&#227;o sistem&#225;tica estudos de caso&#8208;controle de associa&#231;&#227;o gen&#233;tica de variantes no gene <span class="elsevierStyleItalic">MBL2</span> e o risco de desenvolver leishmaniose&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Esta revis&#227;o pesquisou os bancos de dados PubMed&#44; Science Direct&#44; Cochrane Library&#44; Scopus e Lilacs para publica&#231;&#245;es de caso&#8208;controle com seis polimorfismos no gene lectina ligante de manose&#46; Foi usada a estrat&#233;gia&#58; P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>pacientes sob risco de leishmaniose&#59; I<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>presen&#231;a de polimorfismos&#59; C<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>aus&#234;ncia de polimorfismos&#59; O<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>ocorr&#234;ncia de leishmaniose&#46; Quatro estudos de caso&#47;controle consistindo em 791 pacientes com leishmaniose e 967 indiv&#237;duos saud&#225;veis &#40;controle&#41; est&#227;o inclu&#237;dos nesta metan&#225;lise&#46; A associa&#231;&#227;o de variantes no gene lectina ligante de manose e leishmaniose sob o modelo gen&#233;tico al&#233;lico&#44; &#8208;550 &#40;H <span class="elsevierStyleItalic">vs</span>&#46; L&#41;&#44; &#8208;221 &#40;X <span class="elsevierStyleItalic">vs</span>&#46; Y&#41;&#44; &#43;4 &#40;Q <span class="elsevierStyleItalic">vs</span>&#46; P&#41;&#44; CD52 &#40;A <span class="elsevierStyleItalic">vs</span>&#46; D&#41;&#44; CD54 &#40;A <span class="elsevierStyleItalic">vs</span>&#46; B&#41;&#44; CD57 &#40;A <span class="elsevierStyleItalic">vs</span>&#46; C&#41; e gen&#243;tipo A&#47;O &#40;A <span class="elsevierStyleItalic">vs</span>&#46; O&#41; foi avaliado&#46; Registro Internacional Prospectivo de Revis&#245;es Sistem&#225;ticas &#40;PROSPERO&#41;&#58; CRD42020201755&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Os resultados da metan&#225;lise para qualquer modelo gen&#233;tico al&#233;lico n&#227;o mostraram associa&#231;&#227;o significativa para as variantes dentro do promotor&#44; a regi&#227;o n&#227;o traduzida e o &#233;xon 1&#44; bem como para o alelo selvagem A e alelo mutante O com a leishmaniose&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Deve&#8208;se ter cautela ao interpretar esses resultados&#44; pois se baseiam em poucos estudos&#44; os quais apresentam resultados divergentes quando analisados separadamente&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Esta metan&#225;lise n&#227;o mostrou associa&#231;&#227;o significativa entre os polimorfismos rs11003125&#44; rs7096206&#44; rs7095891&#44; rs5030737&#44; rs1800450 e rs1800451 do gene lectina ligante de manose e leishmaniose em qualquer avalia&#231;&#227;o al&#233;lica e heterog&#234;nea&#46;</p></span>"
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                  \t\t\t\t" scope="col">Estudo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Representatividade&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sele&#231;&#227;o de n&#227;o corte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pontua&#231;&#227;o final n&#227;o presente no in&#237;cio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Felipe FJ&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Salsabil H&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Alonso DP&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anshuman M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2929230.png"
              ]
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          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Escala de Newcastle&#8208;Ottawa dos estudos inclu&#237;dos</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">NR&#44; n&#227;o relatado&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pa&#237;s&#47; Regi&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupo &#233;tnico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Formas cl&#237;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Amostras caso controle</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Idade&#44; m&#233;dia de anos<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP ou m&#233;dia &#40;intervalo&#41; caso controle</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SNPs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alonso DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brasil&#47; Nordeste&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Misto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">231&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 meses a 73 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 meses a 73 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">rs11003125&#44; rs7096206&#44; rs5030737&#44; rs1800450&#44; rs1800451&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">De Ara&#250;jo FJ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brasil&#47; Norte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Misto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">382&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">311 homens &#40;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;5 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">225 homens &#40;38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;6 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">rs11003125&#44; rs7096206&#44; rs7095891&#44; rs5030737&#44; rs1800450&#44; rs1800451&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 mulheres &#40;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">157 mulheres &#40;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Salsabil H&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Marrocos &#47; Norte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Africana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">139&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">rs7096206&#44; rs1800450&#44; rs1800451&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anshuman M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#205;ndia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">218&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">215&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;7 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;2 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">rs7095891&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "imagenFichero" => array:1 [
                0 => "xTab2929229.png"
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Leishmaniose&#46; Caracter&#237;sticas dos estudos inclu&#237;dos na revis&#227;o sistem&#225;tica</p>"
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total sample&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">HH&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">LL&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">HL&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alonso DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">29 &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">303 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">de Ara&#250;jo FJ&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">365&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">332&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">49 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">167 &#40;46&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">149 &#40;41&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">265 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">465 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">53 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">147 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">132 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">253 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">411 &#40;62&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">&#8208;221</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">XX</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">XY</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">YY</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">X</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Y</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">XX</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">XY</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">YY</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">X</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Y</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alonso DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;77&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Salsabiln H&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">139&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">71 &#40;51&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">167 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">de Ara&#250;jo FJ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">365&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">332&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">30 &#40;08&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">563 &#40;85&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">&#43;4</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">QQ</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">QP</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">PP</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Q</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">P</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">QQ</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">QP</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">de Ara&#250;jo FJ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">365&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">332&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">17 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">253 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">129 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">601 &#40;82&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">229 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">111 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">551 &#40;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anshuman M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">218&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">215&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">96 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">340 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alonso DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Salsabiln H&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">de Ara&#250;jo FJ&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Alonso DP&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Salsabiln H&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Alonso DP&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">de Ara&#250;jo FJ&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">155 &#40;42&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">84 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">153 &#40;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">439 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">225 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "imagenFichero" => array:1 [
                0 => "xTab2929228.png"
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Modelo gen&#233;tico al&#233;lico adotado na metan&#225;lise para avaliar a associa&#231;&#227;o de polimorfismos do gene <span class="elsevierStyleItalic">MBL2</span> e leishmaniose</p>"
        ]
      ]
    ]
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      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
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            0 => array:3 [
              "identificador" => "bib0205"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Torres-Guerrero"
                            1 => "M&#46;R&#46; Quintanilla-Cedillo"
                            2 => "J&#46; Ruiz-Esmenjaud"
                            3 => "R&#46; Arenas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Leishmaniose&#58; a review&#46;"
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                        "volumen" => "6"
                        "paginaInicial" => "750"
                      ]
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                ]
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            1 => array:3 [
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              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Worldwide risk factors in leishmaniasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Oryan"
                            1 => "M&#46; Akbari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.apjtm.2016.06.021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Asian Pacific Journal of Tropical Medicine&#46;"
                        "fecha" => "2016"
                        "volumen" => "9"
                        "paginaInicial" => "925"
                        "paginaFinal" => "932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27794384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leishmaniasis worldwide and global estimates of its incidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Alvar"
                            1 => "I&#46;D&#46; V&#233;lez"
                            2 => "C&#46; Bern"
                            3 => "M&#46; Herrero"
                            4 => "P&#46; Desjeux"
                            5 => "J&#46; Cano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0035671"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One&#46;"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "e35671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22693548"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "4"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Burza"
                            1 => "S&#46;L&#46; Croft"
                            2 => "M&#46; Boelaert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Leishmaniose&#46; Lancet"
                        "fecha" => "2018"
                        "volumen" => "392"
                        "paginaInicial" => "951"
                        "paginaFinal" => "970"
                      ]
                    ]
                  ]
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              "identificador" => "bib0225"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human genetics of leishmania infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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