Expressões de microRNA no sangue em pacientes com psoríase leve a moderada e relação entre microRNAs e atividade da psoríase | Anais Brasileiros de Dermatologia (Portuguese)

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"idiomaDefecto" => true "cabecera" => "Investigação" "titulo" => "Expressões de microRNA no sangue em pacientes com psoríase leve a moderada e relação entre microRNAs e atividade da psoríase" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "702" "paginaFinal" => "707" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Emine Tugba Alatas, Murat Kara, Gursoy Dogan, Aslı Akın Belli" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Emine Tugba" "apellidos" => "Alatas" "email" => array:1 [ 0 => "dretuba_oz@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Murat" "apellidos" => "Kara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Gursoy" "apellidos" => "Dogan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Aslı Akın" "apellidos" => "Belli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Dermatologia, School of Medicine, University of Muğla Sıtkı Koçman, Mugla, Turquia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Genética Médica, School of Medicine, University of Muğla Sıtkı Koçman, Mugla, Turquia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Erdem, Istambul, Turquia" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondência." ] ] ] ] "textoCompleto" => "IntroduçãoA psoríase é doença dermatológica inflamatória crônica, hiperproliferativa, caracterizada por placas escamosas eritematosas, cuja etiologia é genética.<a class="elsevierStyleCrossRefs" href="#bib0185">1–3</a> Embora a psoríase seja observada em 1% a 3% da população em geral, os pacientes com psoríase constituem 6% a 8% dos indivíduos admitidos nas clínicas de dermatologia.<a class="elsevierStyleCrossRef" href="#bib0200">4</a> Ainda que sua patogênese não possa ser totalmente explicada, a psoríase é considerada uma doença poligênica com interação de fatores genéticos e ambientais. O gen primário de resolução antigênica HLA‐Cw6, localizado no PSORS1 e que codifica um alelo do complexo principal de histocompatibilidade I (MHCI), foi significativamente associado à psoríase. Foram observadas alterações nos genes PSORS1 e PSORS2 no desenvolvimento da doença, afetando células imunes e queratinócitos. Os fatores genéticos afetam os sintomas clínicos, a idade de início da doença, seu tipo e gravidade.<a class="elsevierStyleCrossRefs" href="#bib0205">5,6</a>Os microRNAs (miRNAs) são membros da pequena família de RNA, cujo comprimento varia entre 19 a 25 nucleotídeos.<a class="elsevierStyleCrossRef" href="#bib0215">7</a> Mais de 2.500 miRNAs que desempenham um papel fundamental na regulação de processos biológicos básicos foram identificados até o momento.<a class="elsevierStyleCrossRef" href="#bib0220">8</a> Os miRNAs regulam a expressão gênica durante a transcrição e podem atuar como um gene supressor de tumor e/ou oncogene em doenças ou tecidos específicos.<a class="elsevierStyleCrossRef" href="#bib0225">9</a> Estudos recentes mostraram que os miRNAs estão envolvidos na patogênese da psoríase.<a class="elsevierStyleCrossRefs" href="#bib0230">10–13</a> Após o primeiro estudo que demonstrou a associação entre miRNAs e psoríase, mais de 250 miRNAs foram relatados como expressos de maneira aberrante na psoríase.<a class="elsevierStyleCrossRef" href="#bib0250">14</a> Vários perfis de miRNA foram estudados em amostras de pele, sangue e cabelo de pacientes com psoríase. Polimorfismos genéticos de miRNAs específicos (como miR‐146a) têm sido associados à patogênese da psoríase.<a class="elsevierStyleCrossRefs" href="#bib0255">15,16</a> No entanto, na maioria dos estudos disponíveis, as expressões de miRNA foram demonstradas em lesões cutâneas psoriásicas por meio de painéis de miRNA relativamente pequenos.Este estudo teve como objetivo identificar e caracterizar expressões de miRNA em amostras de sangue de pacientes com psoríase por meio de um grande painel de miRNA e investigar a relação entre a expressão de miRNA e a gravidade da psoríase com o Índice de Área e Gravidade da Psoríase (PASI) e o Índice de Qualidade de Vida em Dermatologia (DLQI).Material e métodosDesenho do estudoEste foi um estudo de caso controle que incluiu 52 pacientes com psoríase e 54 controles saudáveis recrutados nos Departamentos de Dermatologia e Genética Médica da Faculdade de Medicina da Universidade Muğla Sıtkı Koçman. O Comitê de Ética em Pesquisa Clínica da Universidade Muğla Sıtkı Koçman aprovou este estudo. Os pacientes e controles assinaram um termo de consentimento livre e esclarecido. O estudo incluiu 52 pacientes com psoríase vulgar e 54 voluntários de mesma idade e sexo, que foram admitidos no ambulatório de dermatologia e atenderam aos critérios de inclusão/exclusão. Foram incluídos os pacientes com idade > 18 anos que concordaram em participar do estudo. Os seguintes critérios de exclusão foram adotados: idade < 18 anos, pacientes com psoríase que não em placas (psoríase pustulosa e psoríase eritrodérmica, entre outras), pacientes com doenças sistêmicas (como doença coronariana, insuficiência hepática, insuficiência renal e neoplasia maligna) e pacientes grávidas ou lactantes.O histórico médico dos pacientes (idade, duração da doença, presença de artrite psoriásica e comprometimento ungueal e tratamentos atuais) foi registrado no prontuário dos pacientes. A gravidade da doença foi calculada com o escore PASI. Além disso, foram registrados o escore do DLQI dos pacientes.Dois a três mL de sangue dos pacientes foram coletados em tubos de EDTA e enviados ao Laboratório de Genética Médica. Os RNAs dos pacientes foram armazenados a −80°C até a feitura do estudo. Usando o miRNeasy Mini Kit (QIAGEN Sample & Assay Technologies Hilden, Alemanha), o miRNA foi isolado de acordo com o protocolo recomendado pelo fabricante. O kit miScript II RT (Qiagen) foi usado para converter os RNAs obtidos em um DNA computacional (cDNA). Os níveis de expressão do miRNA foram determinados pelo dispositivo Biomark Real‐Time PCR (Fluidigm).Quarenta e dois primers de miRNA que podem estar relacionados à psoríase (hsa‐miR‐155‐5p, hsa‐miR‐31‐5p, hsa‐miR‐99a‐5p, hsa‐miR‐128‐3p, hsa‐miR‐146a‐5p, hsa‐miR‐210‐3p, hsa‐miR‐369‐3p, hsa‐miR‐378a‐3p, hsa‐let‐7i‐5p, hsa‐miR‐193b‐3p, hsa‐miR‐498, hsa‐miR‐551a, hsa‐miR‐1266‐5p, hsa‐let‐7d‐5p, hsa‐miR‐205‐5p, hsa‐let‐7c‐3p, hsa‐let‐7c‐5p, hsa‐miR‐30b‐3p, hsa‐miR‐130a‐5p, hsa‐miR‐515‐3p, hsa‐miR‐21‐5p, hsa‐miR‐125b‐5p, hsa‐miR‐142‐3p, hsa‐miR‐424‐5p, hsa‐miR‐223‐3p, hsa‐miR‐425‐3p, hsa‐miR‐26a‐5p, hsa‐miR‐26b‐5p, hsa‐miR‐106b‐5p, hsa‐miR‐126‐5p, hsa‐miR‐181a‐5p, hsa‐miR‐221‐3p, hsa‐miR‐222‐3p, hsa‐miR‐22‐3p, hsa‐miR‐24‐3p, hsa‐miR‐17‐3p, hsa‐miR‐17‐5p, hsa‐miR‐30b‐5p, and hsa‐miR‐130a‐3p, hsa‐miR‐30e‐5p, hsa‐miR‐16‐5p, and hsa‐miR‐30a‐5p) foram analisados.<a class="elsevierStyleCrossRefs" href="#bib0230">10–13</a>No grupo de pacientes, foi avaliada a relação entre expressão de miRNA e escore do PASI, escore do DLQI e comprometimento ungueal.Análise de dadosA análise estatística do estudo foi feita com o SPSS® for Windows, v. 15.0. Os resultados foram apresentados como média ± desvio‐padrão. A análise foi feita no site <a href="http://www.qiagen.com/us/shop/genes-and-pathways/data-analysis-center-overview-page/">http://www.qiagen.com/us/shop/genes‐and‐pathways/data‐analysis‐center‐overview‐page/</a>. Os resultados da RT‐PCR (valores de Ct) foram calculados pelo método 2‐ΔΔCT. Após o cálculo desses valores, o teste t de Student foi empregado para fazer comparações entre os grupos (cálculo dos valores‐p); valores‐p < 0,05 foram considerados estatisticamente significativos.ResultadosO estudo incluiu 52 pacientes com psoríase (32 mulheres, 20 homens; faixa etária: 18 a 68 anos) e 54 controles (33 mulheres, 21 homens; faixa etária: 18 a 69 anos). A idade média foi de 46,3 ± 17,7 anos e 43,5 ± 16,5 anos nos grupos pacientes e controles, respectivamente (p > 0,05). Enquanto 7,6% dos pacientes foram submetidos a tratamentos sistêmicos (3,8%, ciclosporina; 3,8%, acitretina), 92,4% receberam apenas tratamentos tópicos. No grupo de pacientes, 13,4% apresentaram comprometimento ungueal e 8,2% apresentaram artrite psoriásica. O escore médio do PASI foi de 7,90 ± 8,83 e o escore médio do DLQI foi de 8,13 ± 5,50 no grupo de pacientes (<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>As <a class="elsevierStyleCrossRefs" href="#tbl0010">tabelas 2 e 3</a> apresentam expressões de miRNA reguladas dez para mais e para menos, respectivamente, nos grupos de pacientes e de controles. Observou‐se uma regulação para mais significativa na expressão de hsa‐miR‐155‐5p, hsa‐miR‐369‐3p, hsa‐miR‐193b‐3p, hsa‐miR‐498, hsa‐miR‐1266‐5p, hsa‐let‐7d‐5p, hsa‐miR‐205‐5p, hsa‐let‐7c‐5p, hsa‐miR‐30b‐3p e hsa‐miR‐515‐3p no grupo de pacientes em comparação com o grupo de controles (p < 0,05; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Verificou‐se uma regulação para menos significativa na expressão de hsa‐miR‐21‐5p, hsa‐miR‐142‐3p, hsa‐miR‐424‐5p, hsa‐miR‐223‐3p, hsa‐miR‐26a‐5p, hsa‐miR‐106b‐5p, hsa‐miR‐126‐5p, hsa‐miR‐181a‐5p, hsa‐miR‐222‐3p, hsa‐miR‐22‐3p, hsa‐miR‐24‐3p, hsa‐miR‐17‐3p, hsa‐miR‐30b‐5p, hsa‐miR‐130a‐3p, hsa‐miR‐30e‐5p e hsa‐miR‐16‐5p no grupo de pacientes em comparação com o grupo de controles (p < 0,05; <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>). As Tabelas 2 e 3 também apresentam as fold changes no grupo de pacientes em comparação com o grupo controle.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>No grupo de pacientes, não foi observada relação significativa entre as expressões de miRNA e o escore PASI, o escore DLQI e o comprometimento ungueal.DiscussãoA psoríase é doença inflamatória crônica da pele em cuja patogênese estão envolvidos queratinócitos epidérmicos, células imunes e mediadores inflamatórios. Nos últimos anos, demonstrou‐se que os miRNAs regulam a diferenciação, a proliferação e a resposta de citocinas dos queratinócitos, a sobrevivência e a ativação das células T, bem como a associação entre imunócitos e queratinócitos. Embora diferentes perfis de expressão de miRNAs tenham sido relatados em pacientes com psoríase, os miRNAs não foram identificados como um biomarcador para diagnóstico, atividade e gravidade da doença na prática clínica.<a class="elsevierStyleCrossRef" href="#bib0265">17</a> Embora a maioria dos pacientes incluídos no presente estudo apresentasse doença mais leve, foi observada regulação regulação para cima e para baixo na expressão de miRNA em amostras de soro de pacientes com psoríase; os presentes achados são compatíveis com os dados da literatura existente em amostras de soro e pele de pacientes com psoríase.<a class="elsevierStyleCrossRefs" href="#bib0270">18–20</a> No entanto, no presente estudo, essas expressões de miRNA não estavam significativamente associadas ao escore PASI, DLQI e comprometimento ungueal.Foi demonstrado que muitos miRNAs que envolvem miR‐203 e miR‐125b desempenham papéis‐chave na resposta inflamatória, disfunção imunológica e doenças hiperproliferativas, inclusive psoríase. Sugere‐se que os miRNAs detectados em amostras de sangue podem ser biomarcadores no diagnóstico, prognóstico e resposta ao tratamento.<a class="elsevierStyleCrossRef" href="#bib0285">21</a> No presente estudo, embora o miR‐146a e o miR125b tenham sido regulados para cima e para baixo nos pacientes com psoríase, respectivamente, a associação não foi estatisticamente significativa.A expressão de diversos miRNAs foi relacionada à atividade ou gravidade da psoríase em vários estudos. No estudo de Hou RX et al., verificou‐se maior expressão do miR‐155‐5p nas células‐tronco mesenquimais dérmicas de pacientes com psoríase.<a class="elsevierStyleCrossRef" href="#bib0270">18</a> Guo et al. observaram que a expressão do miR‐369‐3p estava aumentada no soro e na pele dos pacientes com psoríase e associada à atividade da doença.<a class="elsevierStyleCrossRef" href="#bib0275">19</a> Em outro estudo, a expressão de miR‐1266‐5p foi relatada como aumentada no soro de pacientes com psoríase e associada à atividade da doença.<a class="elsevierStyleCrossRef" href="#bib0280">20</a> De forma semelhante, no presente estudo as expressões de miR‐155‐5p, miR‐369‐3p e miR‐1266‐5p estavam significativamente aumentadas em pacientes com psoríase quando comparadas aos controles. No entanto, nenhuma associação estatisticamente significativa foi observada entre miRNAs e gravidade da doença. Esse resultado pode ser devido ao fato de a maioria dos pacientes apresentar psoríase leve ou moderada.O efeito de diversos tratamentos sistêmicos nas expressões de miRNA e o papel dos miRNAs na patogênese da doença foram investigados. Raaby et al. não detectaram alterações na expressão do miRNA quatro dias após o tratamento com adalimumabe, sugeriram que o perfil de expressão de citocinas não é facilitado por alterações precoces na expressão do miRNA.<a class="elsevierStyleCrossRef" href="#bib0290">22</a> Em contraste com o presente estudo, os níveis de miR‐142‐3p estavam aumentados em pacientes com psoríase e diminuíram com o tratamento com etanercepte no estudo de Pivarcsi et al.<a class="elsevierStyleCrossRef" href="#bib0295">23</a> Ichıhara et al. encontraram uma expressão diminuída de miR‐424 nos tecidos de pacientes com psoríase e observaram que a diminuição da expressão de miR‐424 associada a níveis aumentados de MEK1 e ciclina E1 pode induzir a proliferação de queratinócitos na epiderme.<a class="elsevierStyleCrossRef" href="#bib0300">24</a> Da mesma maneira, no presente estudo, a expressão do miR‐424 estava regulada para baixo em pacientes com psoríase quando comparada aos controles.Estudos sobre miRNAs e outras doenças crônicas também podem ser úteis para entender a patogênese e o efeito dos tratamentos sistêmicos na psoríase. Em um estudo feito em pacientes com artrite reumatoide, Xiang et al. observaram que a expressão aumentada de miR‐498 suprimia a diferenciação de células Th17, ao focar em STAT3.<a class="elsevierStyleCrossRef" href="#bib0305">25</a> Em outro estudo de Wang et al., foi demonstrado que miR‐223 causava doença inflamatória intestinal pela via IL23.<a class="elsevierStyleCrossRef" href="#bib0310">26</a> Sabe‐se que a via IL23/17 desempenha um papel fundamental na patogênese da psoríase; tratamentos contra essa via, como o anti‐IL17 (secuquinumabe), são eficazes no tratamento da psoríase.<a class="elsevierStyleCrossRefs" href="#bib0315">27,28</a> Consequentemente, a superexpressão do miR‐498 pode ser eficaz no tratamento da psoríase pela via IL17. Embora os autores não tenham investigado as expressões de miRNA antes e após os tratamentos, observou‐se uma expressão significativamente aumentada de miR‐498 em pacientes com psoríase. Em outro estudo, An et al. demonstraram que a suprarregulação do miR‐205 inibe o desenvolvimento de queloide, suprime a produção do fator de crescimento do endotélio vascular (VEGF).<a class="elsevierStyleCrossRef" href="#bib0325">29</a> Chamorro‐Jorganes et al. relataram que o VEGF estimula as células endoteliais para a angiogênese por indução do miR‐17.<a class="elsevierStyleCrossRef" href="#bib0330">30</a> Como é sabido que o VEGF está envolvido na patogênese da psoríase, esses relatos respaldam a hipótese de que a expressão de miR‐205 e miR‐17 pode afetar o desenvolvimento da psoríase via VEGF.<a class="elsevierStyleCrossRef" href="#bib0335">31</a> No presente estudo, enquanto a expressão de miR‐205‐5p estava significativamente regulada para cima, a expressão de mir‐17‐3p estava significativamente regulada para baixo em pacientes com psoríase quando comparada aos controles.Vários tipos de miRNA estão envolvidos na patogênese de diversos tipos de psoríase. Enquanto a via IL23/Th17 é responsável pelo desenvolvimento da psoríase vulgar, IL‐1, IL‐36 e IL‐6 são citocinas envolvidas no desenvolvimento da psoríase pustulosa.<a class="elsevierStyleCrossRef" href="#bib0340">32</a> Chyi‐Ying et al. relataram que o miR‐26 reduz a IL‐6, que é ativada pelo TNF‐α.<a class="elsevierStyleCrossRef" href="#bib0345">33</a> MiR‐26 pode estar envolvido no desenvolvimento de psoríase mediada por IL‐6. Os medicamentos que suprimem a liberação de IL‐6, como o tocilizumabe, são usados no tratamento da artrite reumatoide e da artrite reumatoide juvenil e estão entre as possíveis opções de tratamento futuro da psoríase pustulosa.<a class="elsevierStyleCrossRef" href="#bib0340">32</a>O transdutor de sinal e ativação da transcrição (STAT3) foi apontado recentemente como um ator‐chave na patogênese da psoríase e de condições inflamatórias similares à psoríase. Relata‐se que a hiperatividade do STAT3 é uma mediadora da sinalização da maioria das citocinas, inclusive a interleucina IL‐23/IL‐17, e é observada em quase todos os tipos de células envolvidas no surgimento da doença.<a class="elsevierStyleCrossRef" href="#bib0350">34</a> Maimaiti et al. apontaram que o miR‐106b modula a angiogênese em células endoteliais e afeta a expressão de STAT3.<a class="elsevierStyleCrossRef" href="#bib0355">35</a> Em outro estudo, foi demonstrado que o STAT3 inibe a expressão de miR‐22 em pacientes com linfoma cutâneo de células T.<a class="elsevierStyleCrossRef" href="#bib0360">36</a> Assim, o miR‐22 pode ser inibido pela patogênese mediada por STAT3 na psoríase. No presente estudo, as expressões de miR‐106b‐5p e miR‐22 foram significativamente reguladas para cima e para baixo nos pacientes com psoríase, respectivamente, respaldando esses achados.O presente estudo tem algumas limitações: apenas pacientes com psoríase leve a moderada foram incluídos e a maioria estava em tratamento tópico; portanto, não foi possível avaliar as alterações na expressão de miRNA antes e após tratamentos sistêmicos. Além disso, os pacientes atuais apresentavam psoríase do tipo placa e, portanto, a expressão de miRNA não foi avaliada em outros tipos de psoríase.ConclusãoO presente estudo incluiu pacientes com psoríase leve a moderada e avaliou miRNAs de amostras de sangue em vez de lesões cutâneas; um determinado conjunto de miRNAs estava regulado para mais ou para menos nos pacientes com psoríase, um achado compatível com a literatura existente. Portanto, os presentes resultados confirmam mais uma vez o papel dos miRNAs na patogênese da psoríase. No entanto, não foi observada associação entre a expressão de miRNA e o escore PASI, o escore DLQI e o comprometimento ungueal nos pacientes. Estudos adicionais devem ser feitos para entender melhor se os miRNAs podem ser usados como um marcador para o prognóstico da psoríase, qual miRNA é mais específico para cada tipo de psoríase e se os miRNAs podem ser usados no tratamento da psoríase no futuro.Suporte financeiroNenhum.Contribuição dos autoresEmine Tugba Alatas: Concepção e planejamento do estudo; elaboração e redação do manuscrito; obtenção, análise e interpretação dos dados; participação efetiva na orientação da pesquisa; participação intelectual em conduta propedêutica e/ou terapêutica de casos estudados.Murat Kara: Análise estatística; concepção e planejamento do estudo; obtenção, análise e interpretação dos dados.Gursoy Dogan: Aprovação da versão final do manuscrito; revisão crítica do manuscrito.Aslı Akın Belli: Aprovação da versão final do manuscrito; revisão crítica da literatura; revisão crítica do manuscrito.Conflitos de interesseNenhum." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1434521" "titulo" => "Resumo" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Fundamentos" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Limitações do estudo" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusão" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1309557" "titulo" => "Palavras‐chave" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introdução" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Material e métodos" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Desenho do estudo" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Análise de dados" ] ] ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Resultados" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussão" ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Conclusão" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Suporte financeiro" ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "Contribuição dos autores" ] 9 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflitos de interesse" ] 10 => array:1 [ "titulo" => "Referências" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-10-10" "fechaAceptado" => "2020-04-04" "PalabrasClave" => array:1 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras‐chave" "identificador" => "xpalclavsec1309557" "palabras" => array:3 [ 0 => "Biomarcadores farmacológicos" 1 => "MicroRNAs" 2 => "Psoríase" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "FundamentosEm estudos recentes, os microRNAs (miRNAs) demonstraram desempenhar um papel importante na patogênese da psoríase. No entanto, a literatura apresenta poucos estudos que avaliem miRNAs no sangue de pacientes com psoríase, inclusive um grande número de painéis de miRNA. ObjetivoAvaliar a expressão de miRNA em amostras de sangue de pacientes com psoríase, bem como avaliar a associação entre a expressão de miRNA e a gravidade da psoríase. MétodosEstudo de caso controle em 52 pacientes com psoríase vulgar e 54 controles. O histórico médico dos pacientes, os escores do Índice de Gravidade da Psoríase por Área (PASI) e do Índice de Qualidade de Vida em Dermatologia (DLQI, do inglês Dermatology Life Quality Index) foram registrados. Os 42 primers de miRNA relacionados à doença foram avaliados por PCR em tempo real. ResultadosNo grupo de pacientes, 13,4% apresentaram comprometimento ungueal e 8,2% apresentaram artrite psoriásica. Os escores médios do PASI e DLQI foram 7,90 ± 8,83 e 8,13 ± 5,50, respectivamente. Entre os 42 primers de miRNA, as expressões de hsa‐miR‐155‐5p, hsa‐miR‐369‐3p, hsa‐miR‐193b‐3p, hsa‐miR‐498, hsa‐miR‐1266‐5p, hsa‐let‐7d‐5p, hsa‐miR‐205‐5p, hsa‐let‐7c‐5p, hsa‐miR‐30b‐3p e hsa‐miR‐515‐3p estavam significativamente reguladas para cima, enquanto as expressões de hsa‐miR‐21‐5p, hsa‐miR‐142‐3p, hsa‐miR‐424‐5p, hsa‐miR‐223‐3p, hsa‐miR‐26a‐5p, hsa‐miR‐106b‐5p, hsa‐miR‐126‐5p, hsa‐miR‐181a‐5p, hsa‐miR‐222‐3p, hsa‐miR‐22‐3p, hsa‐miR‐24‐3p, hsa‐miR‐17‐3p, hsa‐miR‐30b‐5p, hsa‐miR‐130a‐3p, hsa‐miR‐30e‐5p e hsa‐miR‐16‐5p estavam significativamente reguladas para baixo em pacientes com psoríase em comparação ao grupo controle (p < 0,05). Limitações do estudoUma vez que o estudo incluiu pacientes com psoríase leve a moderada, que na maioria das vezes só receberam tratamentos tópicos, as alterações nos miRNAs antes e depois dos tratamentos sistêmicos não foram avaliadas. ConclusãoA detecção de regulação para cima ou para baixo na expressão de 24 miRNA em pacientes com psoríase, mesmo naqueles com doença mais leve, respalda ainda mais o papel dos miRNAs na patogênese da psoríase. Estudos futuros devem esclarecer se os miRNAs podem ser usados como um marcador para o prognóstico da psoríase ou como um agente terapêutico no tratamento da psoríase." "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Fundamentos" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Limitações do estudo" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusão" ] ] ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Como citar este artigo: Alatas ET, Kara M, Dogan G, Belli AA. Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity. An Bras Dermatol. 2020;95:702–7." ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "Trabalho realizado no Departamento de Dermatologia, University of Muğla Sıtkı Koçman, Mugla, Turquia." ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Tabela 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Tabela " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Psoríase (n = 52) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controle (n = 54) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Idade (anos) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46,30 ± 17,73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43,53 ± 16,52 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sexo (feminino/masculino) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32/20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33/21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tratamento tópico (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tratamento sistêmico (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Acitretina (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ciclosporina (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Artrite psoriática (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8,2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comprometimento ungueal (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13,4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PASI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7,90 ± 8,83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DLQI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8,13 ± 5,50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2467468.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "Características sociodemográficas e parâmetros bioquímicos dos grupos pacientes e controles" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Tabela 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Tabela " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Δ, Delta; ˄, regulação para mais (vermelho).Valores de fold change e fold regulation maiores que 2 estão apresentados em vermelho." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">miRNA \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controles</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Psoríase vulgar \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">(n = 20) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2∧/‐Méd. (ΔΔCt) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2∧/‐Méd. (ΔΔCt) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fold change \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">valor‐p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐155‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,02983 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033644 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1279 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,03163 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐31‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,032959 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,035317 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,0715 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,8496 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐99a‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,053615 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,0209 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,96027 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐128‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,02978 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033138 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1128 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,07311 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐146a‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,032379 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033843 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,0452 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,60549 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐210‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,034191 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,034284 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,0027 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,7119 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐369‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033069 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1359 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,01889 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐378a‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,043387 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,049672 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1449 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,382 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐let‐7i‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,031176 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033099 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,0617 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,63498 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐193b‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1341 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,02016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐498 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033168 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1393 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,01674 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐551a \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,408725 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,461312 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,0373 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,24357 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐1266‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1341 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,02016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐let‐7d‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1341 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,02016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐205‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,02969 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1121 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,04596 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐let‐7c‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,030431 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,034069 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1195 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,64995 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐let‐7c‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029554 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1172 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,04084 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐30b‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033312 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1442 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,0142 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐130a‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029856 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033552 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1238 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,1268 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐515‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,029856 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033552 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,1238 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,03631 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2467469.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "miRNAs com expressão regulada para mais nos grupos de pacientes e de controles" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Tabela 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Tabela " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Δ, Delta; ˅, regulação para menos (azul).Valores de fold change menores que 0,5 são indicados em azul." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">miRNA \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controle</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Psoríase vulgar \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">(n = 22) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2∧(‐Méd. (ΔΔCt) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2∧(‐Méd. (ΔΔCt) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fold change \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">valor‐p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐21‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,193773 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,045936 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,2371˅ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,00039 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐125b‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,053615 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,042915 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,8004 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,10844 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐142‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,107994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,042771 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,3943 ˅ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,00214 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐424‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,147849 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,043429 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,2937 ˅ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,000103 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐223‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,911406 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,066345 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,0347 ˅ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,00067 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐425‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,709862 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,684317 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,964 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,20361 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐26a‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,060076 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,03822 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,6362 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,0107 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐26b‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,038971 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,033936 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,8708 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,08779 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐106b‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,059833 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,036577 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,6113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,00391 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐126‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,048731 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,036668 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,7525 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,01229 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐181a‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,045429 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,035526 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,782 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,00952 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐221‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,039388 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,035623 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,9044 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,12515 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐222‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,097659 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,043537 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,4458˅ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,00102 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐22‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,092048 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,040819 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,4434˅ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,0005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐24‐3p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,128319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,043497 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,339˅ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,00018 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; 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entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">hsa‐miR‐30a‐5p \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,05877 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,04679 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,7962 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,11647 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2467470.png" ] ] ] ] "descripcion" => array:1 [ "pt" => "miRNAs com expressão regulada para menos nos grupos de pacientes e controles" ] ] ] "bibliografia" => array:2 [ "titulo" => "Referências" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib0185" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.E. Gudjonsson" 1 => "J.T. Elder" 2 => "Psoriasis:" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2007.08.007" "Revista" => array:6 [ "tituloSerie" => "Epidemiology. Clin Dermatol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "535" "paginaFinal" => "546" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18021890" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0190" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical dermatology: a color guide to diagnosis and therapy." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.P. Habif" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "8.ª ed" "fecha" => "2016" "editorial" => "Elsevier" "editorialLocalizacion" => "China" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0195" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.E. Gudjonsson" 1 => "J.T. Elder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "L.A.Goldsmith, S.I.Katz, B.A.Gilchrest, A.S.Paller, D.J.Leffell, K.Wolff" "titulo" => "Fitzpatrick's dermatology in general medicine." "paginaInicial" => "213" "paginaFinal" => "247" "edicion" => "8th ed." "serieFecha" => "2012" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0200" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.C.M. Van de Kerkhof" 1 => "F.O. Nestle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "J.L.Bolognia, J.Schaffer, L.Cerroni" "titulo" => "Dermatology." "paginaInicial" => "138" "paginaFinal" => "160" "edicion" => "4ª ed." "serieFecha" => "2018" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0205" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The immunogenetics of psoriasis: a comprehensive review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.L. Harden" 1 => "J.C. Krueger" 2 => "A. Bowcock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaut.2015.07.008" "Revista" => array:6 [ "tituloSerie" => "J Autoimmun." "fecha" => "2015" "volumen" => "64" "paginaInicial" => "66" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26215033" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0210" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunopathogenic mechanisms in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.E. Gudjonsson" 1 => "A. Johnston" 2 => "H. Sigmundsdottir" 3 => "H. Valdimarsson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2249.2004.02310.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Immunol." "fecha" => "2004" "volumen" => "135" "paginaInicial" => "1" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14678257" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0215" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of microRNAs in cardiac preconditioning" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.N. Salloum" 1 => "C. Yin" 2 => "R.C. Kukreja" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/FJC.0b013e3181f581ba" "Revista" => array:6 [ "tituloSerie" => "J Cardiovasc Pharmacol." "fecha" => "2010" "volumen" => "56" "paginaInicial" => "581" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20980922" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0220" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The expanding microRNA world in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Sonkoly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/exd.13275" "Revista" => array:6 [ "tituloSerie" => "Exp Dermatol." "fecha" => "2017" "volumen" => "26" "paginaInicial" => "375" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27992082" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0225" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between SNPs in pre‐miRNA and risk of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.J. Li" 1 => "L.B. Gao" 2 => "M.L. Lv" 3 => "W. Dong" 4 => "X.W. Su" 5 => "W.B. Liang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clinbiochem.2011.04.021" "Revista" => array:7 [ "tituloSerie" => "Clin Biochem." "fecha" => "2011" "volumen" => "44" "paginaInicial" => "813" "paginaFinal" => "816" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21565178" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1470204518301426" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0230" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic polymorphisms altering microRNA activity in psoriasis − a key to solve the puzzle of missing heritability?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Pivarcsi" 1 => "M. Ståhle" 2 => "E. Sonkoly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/exd.12469" "Revista" => array:6 [ "tituloSerie" => "Exp Dermatol." "fecha" => "2014" "volumen" => "23" "paginaInicial" => "620" "paginaFinal" => "624" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24917490" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0235" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MicroRNA‐223 and miR‐143 are important systemic biomarkers for disease activity in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.B. Løvendorf" 1 => "J.R. Zibert" 2 => "M. Gyldenløve" 3 => "M.A. Røpke" 4 => "L. Skov" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdermsci.2014.05.005" "Revista" => array:6 [ "tituloSerie" => "J Dermatol Sci." "fecha" => "2014" "volumen" => "75" "paginaInicial" => "133" "paginaFinal" => "139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24909097" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0240" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of pro‐inflammatory cytokines TNFα and IL24 by microRNA‐203 in primary keratinocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.N. Primo" 1 => "R.O. Bak" 2 => "B. Schibler" 3 => "J.G. Mikkelsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cyto.2012.07.031" "Revista" => array:6 [ "tituloSerie" => "Cytokine." "fecha" => "2012" "volumen" => "60" "paginaInicial" => "741" "paginaFinal" => "748" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22917968" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0245" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Up‐regulation of microRNA‐210 induces immune dysfunction via targeting FOXP3 in CD4(+) T cells of psoriasis vulgaris" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Zhao" 1 => "L.T. Wang" 2 => "G.P. Liang" 3 => "P. Zhang" 4 => "X.J. Deng" 5 => "Q. Tang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Immunol." "fecha" => "2014" "volumen" => "150" "paginaInicial" => "22" "paginaFinal" => "30" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0250" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Sonkoly" 1 => "T. Wei" 2 => "P.C. Janson" 3 => "A. Sääf" 4 => "L. Lundeberg" 5 => "M. Tengvall-Linder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "PLoS One." "fecha" => "2007" "volumen" => "2" "paginaInicial" => "e610" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0255" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A single‐nucleotide polymorphism of miR‐146a and psoriasis: an association and functional study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Zhang" 1 => "X. Yi" 2 => "S. Guo" 3 => "Q. Shi" 4 => "C. Wei" 5 => "X. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jcmm.12359" "Revista" => array:6 [ "tituloSerie" => "J Cell Mol Med." "fecha" => "2014" "volumen" => "18" "paginaInicial" => "2225" "paginaFinal" => "2234" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25209759" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0260" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MiR‐146a modulates autoreactive Th17 cell differentiation and regulates organ‐specific autoimmunity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Li" 1 => "X. Wang" 2 => "I.Y. Choi" 3 => "Y.C. Wang" 4 => "S. Liu" 5 => "A.T. Pham" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI94012" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest." "fecha" => "2017" "volumen" => "127" "paginaInicial" => "3702" "paginaFinal" => "3716" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28872459" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0265" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of narrow‐band ultraviolet B phototherapy on p63 and microRNA (miR‐21 and miR‐125b) expression in psoriatic epidermis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "X. Gu" 1 => "E. Nylander" 2 => "P.J. Coates" 3 => "K. Nylander" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-1086" "Revista" => array:7 [ "tituloSerie" => "Acta Derm Venereol." "fecha" => "2011" "volumen" => "91" "paginaInicial" => "392" "paginaFinal" => "397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21373745" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1470204518307009" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0270" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased miR‐155‐5p expression in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA expression profile by microarray" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.X. Hou" 1 => "R.F. Liu" 2 => "X.C. Zhao" 3 => "Y.R. Jia" 4 => "P. An" 5 => "Z.P. Hao" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Genet Mol Res." "fecha" => "2016" "paginaInicial" => "15" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0275" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum and skin levels of miR‐369‐3p in patients with psoriasis and their correlation with disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Guo" 1 => "W. Zhang" 2 => "C. Wei" 3 => "L. Wang" 4 => "G. Zhu" 5 => "Q. Shi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ejd.2013.2148" "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol." "fecha" => "2013" "volumen" => "23" "paginaInicial" => "608" "paginaFinal" => "613" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24135466" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0280" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent progress in studies of miRNA and skin diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Jinnin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1346-8138.12904" "Revista" => array:6 [ "tituloSerie" => "J Dermatol." "fecha" => "2015" "volumen" => "42" "paginaInicial" => "551" "paginaFinal" => "558" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25917002" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0285" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An exploration of the role of microRNAs in psoriasis: a systematic review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.Y. Huang" 1 => "L. Li" 2 => "M.J. Wang" 3 => "X.M. Chen" 4 => "Q.C. Huang" 5 => "C.J. Lu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MD.0000000000002030" "Revista" => array:6 [ "tituloSerie" => "Medicine (Baltimore)." "fecha" => "2015" "volumen" => "94" "paginaInicial" => "e2030" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26559308" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1470204515701221" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0290" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in mRNA expression precede changes in microRNA expression in lesional psoriatic skin during treatment with adalimumab" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Raaby" 1 => "A. Langkilde" 2 => "R.B. Kjellerup" 3 => "H. Vinter" 4 => "S.H. Khatib" 5 => "K.F. Hjuler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.13721" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2015" "volumen" => "173" "paginaInicial" => "436" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25662483" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0295" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor‐α therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Pivarcsi" 1 => "F. Meisgen" 2 => "N. Xu" 3 => "M. Ståhle" 4 => "E. Sonkoly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2013" "volumen" => "169" "paginaInicial" => "563" "paginaFinal" => "570" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0300" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "microRNA‐mediated keratinocyte hyperproliferation in psoriasis vulgaris" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Ichihara" 1 => "M. Jinnin" 2 => "K. Yamane" 3 => "A. Fujisawa" 4 => "K. Sakai" 5 => "S. Masuguchi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2011.10497.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2011" "volumen" => "165" "paginaInicial" => "1003" "paginaFinal" => "1010" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21711342" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0305" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Upregulation of miR‐498 suppresses Th17 cell differentiation by targeting STAT3 in rheumatoid arthritis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.Y. Xiang" 1 => "F. Pan" 2 => "J.Z. Yan" 3 => "L.Q. Hong" 4 => "L.H. Zhang" 5 => "Y.H. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Acta Physiologica Sinica." "fecha" => "2018" "volumen" => "70" "paginaInicial" => "167" "paginaFinal" => "174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29691581" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673618315599" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0310" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Wang" 1 => "K. Chao" 2 => "Chien Ng" 3 => "A.H. Bai" 4 => "Q. Yu" 5 => "J. Yu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13059-016-0901-8" "Revista" => array:5 [ "tituloSerie" => "Pro‐inflammatory miR‐223 mediates the cross‐talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease Genome Biol." "fecha" => "2016" "volumen" => "17" "paginaInicial" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27029486" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0315" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The interleukin‐23/interleukin‐17 axis links adaptive and innate immunity in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.P. Schön" 1 => "L. Erpenbeck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fimmu.2018.01323" "Revista" => array:5 [ "tituloSerie" => "Front Immunol." "fecha" => "2018" "volumen" => "9" "paginaInicial" => "1323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29963046" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0320" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mazurek U3. Antiα blockers. Overview of reports on the effectiveness of therapy with IL12/IL23 and T and B lymphocyte inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Wcisło-Dziadecka" 1 => "M. Zbiciak" 2 => "L. Brzezińska-Wcisło" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Postepy Hig Med Dosw (Online)" "fecha" => "2016" "volumen" => "70" "paginaInicial" => "1198" "paginaFinal" => "1205" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0325" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Upregulation of microRNA‐205 suppresses vascular endothelial growth factor expression‐mediated PI3K/Akt signaling transduction in human keloid fibroblasts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. An" 1 => "S. Liang" 2 => "C. Sheng" 3 => "Y. Liu" 4 => "W. Yao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1535370216669839" "Revista" => array:6 [ "tituloSerie" => "Exp Biol Med (Maywood)." "fecha" => "2017" "volumen" => "242" "paginaInicial" => "275" "paginaFinal" => "285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27651436" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0330" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "VEGF‐induced expression of miR‐17‐92 cluster in endothelial cells is mediated by ERK/ELK1 activation and regulates angiogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Chamorro-Jorganes" 1 => "M.Y. Lee" 2 => "E. Araldi" 3 => "S. Landskroner-Eiger" 4 => "M. Fernández-Fuertes" 5 => "M. Sahraei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCRESAHA.115.307408" "Revista" => array:6 [ "tituloSerie" => "Circ Res." "fecha" => "2016" "volumen" => "118" "paginaInicial" => "38" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26472816" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0335" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum vascular endothelial growth factor receptor 3 as a potential biomarker in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "X. Hong" 1 => "S. Jiang" 2 => "N. Marmolejo" 3 => "R. Vangipuram" 4 => "E. Ramos-Rojas" 5 => "Y. Yuan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/exd.13727" "Revista" => array:6 [ "tituloSerie" => "Exp Dermatol." "fecha" => "2018" "volumen" => "27" "paginaInicial" => "1053" "paginaFinal" => "1057" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29957828" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0340" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL‐6 as a druggable target in psoriasis: focus on pustular variants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Saggini" 1 => "S. Chimenti" 2 => "A. Chiricozzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2014/964069" "Revista" => array:5 [ "tituloSerie" => "J Immunol Res." "fecha" => "2014" "volumen" => "2014" "paginaInicial" => "964069" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25126586" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0345" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MiR‐26 down‐regulates TNF‐α/NF‐κB signalling and IL‐6 expression by silencing HMGA1 and MALT1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.C. Chyi-Ying" 1 => "J.T. Chang" 2 => "H. Yi-Fang" 3 => "S. Ann-Bin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/nar/gkw205" "Revista" => array:6 [ "tituloSerie" => "Nucleic Acids Res." "fecha" => "2016" "volumen" => "44" "paginaInicial" => "3772" "paginaFinal" => "3787" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27025651" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0350" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis: A STAT3‐centric view" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Calautti" 1 => "L. Avalle" 2 => "V. Poli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Int J Mol Sci." "fecha" => "2018" "volumen" => "19" "paginaInicial" => "171" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0355" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MiR‐106b exhibits an anti‐angiogenic function by inhibiting STAT3 expression in endothelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Maimaiti" 1 => "A. Maimaiti" 2 => "Y. Yang" 3 => "Y. Ma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12944-016-0216-5" "Revista" => array:5 [ "tituloSerie" => "Lipids Health Dis." 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Estatísticas

Investigação

Expressões de microRNA no sangue em pacientes com psoríase leve a moderada e relação entre microRNAs e atividade da psoríase

Emine Tugba Alatasa,

Autor para correspondência

dretuba_oz@hotmail.com

Autor para correspondência.

, Murat Karab, Gursoy Dogana, Aslı Akın Bellic

a Departamento de Dermatologia, School of Medicine, University of Muğla Sıtkı Koçman, Mugla, Turquia

b Departamento de Genética Médica, School of Medicine, University of Muğla Sıtkı Koçman, Mugla, Turquia

c Hospital Erdem, Istambul, Turquia

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7364

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O gen prim&#225;rio de resolu&#231;&#227;o antig&#234;nica HLA&#8208;Cw6&#44; localizado no PSORS1 e que codifica um alelo do complexo principal de histocompatibilidade I &#40;MHCI&#41;&#44; foi significativamente associado &#224; psor&#237;ase&#46; Foram observadas altera&#231;&#245;es nos genes PSORS1 e PSORS2 no desenvolvimento da doen&#231;a&#44; afetando c&#233;lulas imunes e queratin&#243;citos&#46; Os fatores gen&#233;ticos afetam os sintomas cl&#237;nicos&#44; a idade de in&#237;cio da doen&#231;a&#44; seu tipo e gravidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Os microRNAs &#40;miRNAs&#41; s&#227;o membros da pequena fam&#237;lia de RNA&#44; cujo comprimento varia entre 19 a 25 nucleot&#237;deos&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> Mais de 2&#46;500 miRNAs que desempenham um papel fundamental na regula&#231;&#227;o de processos biol&#243;gicos b&#225;sicos foram identificados at&#233; o momento&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">8</span></a> Os miRNAs regulam a express&#227;o g&#234;nica durante a transcri&#231;&#227;o e podem atuar como um gene supressor de tumor e&#47;ou oncogene em doen&#231;as ou tecidos espec&#237;ficos&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">9</span></a> Estudos recentes mostraram que os miRNAs est&#227;o envolvidos na patog&#234;nese da psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#8211;13</span></a> Ap&#243;s o primeiro estudo que demonstrou a associa&#231;&#227;o entre miRNAs e psor&#237;ase&#44; mais de 250 miRNAs foram relatados como expressos de maneira aberrante na psor&#237;ase&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a> V&#225;rios perfis de miRNA foram estudados em amostras de pele&#44; sangue e cabelo de pacientes com psor&#237;ase&#46; Polimorfismos gen&#233;ticos de miRNAs espec&#237;ficos &#40;como miR&#8208;146a&#41; t&#234;m sido associados &#224; patog&#234;nese da psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">15&#44;16</span></a> No entanto&#44; na maioria dos estudos dispon&#237;veis&#44; as express&#245;es de miRNA foram demonstradas em les&#245;es cut&#226;neas psori&#225;sicas por meio de pain&#233;is de miRNA relativamente pequenos&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Este estudo teve como objetivo identificar e caracterizar express&#245;es de miRNA em amostras de sangue de pacientes com psor&#237;ase por meio de um grande painel de miRNA e investigar a rela&#231;&#227;o entre a express&#227;o de miRNA e a gravidade da psor&#237;ase com o &#205;ndice de &#193;rea e Gravidade da Psor&#237;ase &#40;PASI&#41; e o &#205;ndice de Qualidade de Vida em Dermatologia &#40;DLQI&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Desenho do estudo</span><p id="par0020" class="elsevierStylePara elsevierViewall">Este foi um estudo de caso controle que incluiu 52 pacientes com psor&#237;ase e 54 controles saud&#225;veis recrutados nos Departamentos de Dermatologia e Gen&#233;tica M&#233;dica da Faculdade de Medicina da Universidade Mu&#287;la S&#305;tk&#305; Ko&#231;man&#46; O Comit&#234; de &#201;tica em Pesquisa Cl&#237;nica da Universidade Mu&#287;la S&#305;tk&#305; Ko&#231;man aprovou este estudo&#46; Os pacientes e controles assinaram um termo de consentimento livre e esclarecido&#46; O estudo incluiu 52 pacientes com psor&#237;ase vulgar e 54 volunt&#225;rios de mesma idade e sexo&#44; que foram admitidos no ambulat&#243;rio de dermatologia e atenderam aos crit&#233;rios de inclus&#227;o&#47;exclus&#227;o&#46; Foram inclu&#237;dos os pacientes com idade &#62; 18 anos que concordaram em participar do estudo&#46; Os seguintes crit&#233;rios de exclus&#227;o foram adotados&#58; idade &#60; 18 anos&#44; pacientes com psor&#237;ase que n&#227;o em placas &#40;psor&#237;ase pustulosa e psor&#237;ase eritrod&#233;rmica&#44; entre outras&#41;&#44; pacientes com doen&#231;as sist&#234;micas &#40;como doen&#231;a coronariana&#44; insufici&#234;ncia hep&#225;tica&#44; insufici&#234;ncia renal e neoplasia maligna&#41; e pacientes gr&#225;vidas ou lactantes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">O hist&#243;rico m&#233;dico dos pacientes &#40;idade&#44; dura&#231;&#227;o da doen&#231;a&#44; presen&#231;a de artrite psori&#225;sica e comprometimento ungueal e tratamentos atuais&#41; foi registrado no prontu&#225;rio dos pacientes&#46; A gravidade da doen&#231;a foi calculada com o escore PASI&#46; Al&#233;m disso&#44; foram registrados o escore do DLQI dos pacientes&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Dois a tr&#234;s mL de sangue dos pacientes foram coletados em tubos de EDTA e enviados ao Laborat&#243;rio de Gen&#233;tica M&#233;dica&#46; Os RNAs dos pacientes foram armazenados a &#8722;80<span class="elsevierStyleHsp" style=""></span>&#176;C at&#233; a feitura do estudo&#46; Usando o <span class="elsevierStyleItalic">miRNeasy Mini Kit</span> &#40;QIAGEN Sample &#38; Assay Technologies Hilden&#44; Alemanha&#41;&#44; o miRNA foi isolado de acordo com o protocolo recomendado pelo fabricante&#46; O <span class="elsevierStyleItalic">kit miScript II RT</span> &#40;Qiagen&#41; foi usado para converter os RNAs obtidos em um DNA computacional &#40;cDNA&#41;&#46; Os n&#237;veis de express&#227;o do miRNA foram determinados pelo dispositivo <span class="elsevierStyleItalic">Biomark Real&#8208;Time PCR</span> &#40;Fluidigm&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Quarenta e dois primers de miRNA que podem estar relacionados &#224; psor&#237;ase &#40;hsa&#8208;miR&#8208;155&#8208;5p&#44; hsa&#8208;miR&#8208;31&#8208;5p&#44; hsa&#8208;miR&#8208;99a&#8208;5p&#44; hsa&#8208;miR&#8208;128&#8208;3p&#44; hsa&#8208;miR&#8208;146a&#8208;5p&#44; hsa&#8208;miR&#8208;210&#8208;3p&#44; hsa&#8208;miR&#8208;369&#8208;3p&#44; hsa&#8208;miR&#8208;378a&#8208;3p&#44; hsa&#8208;let&#8208;7i&#8208;5p&#44; hsa&#8208;miR&#8208;193b&#8208;3p&#44; hsa&#8208;miR&#8208;498&#44; hsa&#8208;miR&#8208;551a&#44; hsa&#8208;miR&#8208;1266&#8208;5p&#44; hsa&#8208;let&#8208;7d&#8208;5p&#44; hsa&#8208;miR&#8208;205&#8208;5p&#44; hsa&#8208;let&#8208;7c&#8208;3p&#44; hsa&#8208;let&#8208;7c&#8208;5p&#44; hsa&#8208;miR&#8208;30b&#8208;3p&#44; hsa&#8208;miR&#8208;130a&#8208;5p&#44; hsa&#8208;miR&#8208;515&#8208;3p&#44; hsa&#8208;miR&#8208;21&#8208;5p&#44; hsa&#8208;miR&#8208;125b&#8208;5p&#44; hsa&#8208;miR&#8208;142&#8208;3p&#44; hsa&#8208;miR&#8208;424&#8208;5p&#44; hsa&#8208;miR&#8208;223&#8208;3p&#44; hsa&#8208;miR&#8208;425&#8208;3p&#44; hsa&#8208;miR&#8208;26a&#8208;5p&#44; hsa&#8208;miR&#8208;26b&#8208;5p&#44; hsa&#8208;miR&#8208;106b&#8208;5p&#44; hsa&#8208;miR&#8208;126&#8208;5p&#44; hsa&#8208;miR&#8208;181a&#8208;5p&#44; hsa&#8208;miR&#8208;221&#8208;3p&#44; hsa&#8208;miR&#8208;222&#8208;3p&#44; hsa&#8208;miR&#8208;22&#8208;3p&#44; hsa&#8208;miR&#8208;24&#8208;3p&#44; hsa&#8208;miR&#8208;17&#8208;3p&#44; hsa&#8208;miR&#8208;17&#8208;5p&#44; hsa&#8208;miR&#8208;30b&#8208;5p&#44; and hsa&#8208;miR&#8208;130a&#8208;3p&#44; hsa&#8208;miR&#8208;30e&#8208;5p&#44; hsa&#8208;miR&#8208;16&#8208;5p&#44; and hsa&#8208;miR&#8208;30a&#8208;5p&#41; foram analisados&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#8211;13</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">No grupo de pacientes&#44; foi avaliada a rela&#231;&#227;o entre express&#227;o de miRNA e escore do PASI&#44; escore do DLQI e comprometimento ungueal&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">An&#225;lise de dados</span><p id="par0050" class="elsevierStylePara elsevierViewall">A an&#225;lise estat&#237;stica do estudo foi feita com o SPSS&#174; for Windows&#44; v&#46; 15&#46;0&#46; Os resultados foram apresentados como m&#233;dia &#177; desvio&#8208;padr&#227;o&#46; A an&#225;lise foi feita no site <a href="http://www.qiagen.com/us/shop/genes-and-pathways/data-analysis-center-overview-page/">http&#58;&#47;&#47;www&#46;qiagen&#46;com&#47;us&#47;shop&#47;genes&#8208;and&#8208;pathways&#47;data&#8208;analysis&#8208;center&#8208;overview&#8208;page&#47;</a>&#46; Os resultados da RT&#8208;PCR &#40;valores de Ct&#41; foram calculados pelo m&#233;todo 2&#8208;&#916;&#916;CT&#46; Ap&#243;s o c&#225;lculo desses valores&#44; o teste <span class="elsevierStyleItalic">t</span> de Student foi empregado para fazer compara&#231;&#245;es entre os grupos &#40;c&#225;lculo dos valores&#8208;p&#41;&#59; valores&#8208;p &#60; 0&#44;05 foram considerados estatisticamente significativos&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">O estudo incluiu 52 pacientes com psor&#237;ase &#40;32 mulheres&#44; 20 homens&#59; faixa et&#225;ria&#58; 18 a 68 anos&#41; e 54 controles &#40;33 mulheres&#44; 21 homens&#59; faixa et&#225;ria&#58; 18 a 69 anos&#41;&#46; A idade m&#233;dia foi de 46&#44;3 &#177; 17&#44;7 anos e 43&#44;5 &#177; 16&#44;5 anos nos grupos pacientes e controles&#44; respectivamente &#40;p &#62; 0&#44;05&#41;&#46; Enquanto 7&#44;6&#37; dos pacientes foram submetidos a tratamentos sist&#234;micos &#40;3&#44;8&#37;&#44; ciclosporina&#59; 3&#44;8&#37;&#44; acitretina&#41;&#44; 92&#44;4&#37; receberam apenas tratamentos t&#243;picos&#46; No grupo de pacientes&#44; 13&#44;4&#37; apresentaram comprometimento ungueal e 8&#44;2&#37; apresentaram artrite psori&#225;sica&#46; O escore m&#233;dio do PASI foi de 7&#44;90 &#177; 8&#44;83 e o escore m&#233;dio do DLQI foi de 8&#44;13 &#177; 5&#44;50 no grupo de pacientes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">As <a class="elsevierStyleCrossRefs" href="#tbl0010">tabelas 2 e 3</a> apresentam express&#245;es de miRNA reguladas dez para mais e para menos&#44; respectivamente&#44; nos grupos de pacientes e de controles&#46; Observou&#8208;se uma regula&#231;&#227;o para mais significativa na express&#227;o de hsa&#8208;miR&#8208;155&#8208;5p&#44; hsa&#8208;miR&#8208;369&#8208;3p&#44; hsa&#8208;miR&#8208;193b&#8208;3p&#44; hsa&#8208;miR&#8208;498&#44; hsa&#8208;miR&#8208;1266&#8208;5p&#44; hsa&#8208;let&#8208;7d&#8208;5p&#44; hsa&#8208;miR&#8208;205&#8208;5p&#44; hsa&#8208;let&#8208;7c&#8208;5p&#44; hsa&#8208;miR&#8208;30b&#8208;3p e hsa&#8208;miR&#8208;515&#8208;3p no grupo de pacientes em compara&#231;&#227;o com o grupo de controles &#40;p&#160;&#60;&#160;0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Verificou&#8208;se uma regula&#231;&#227;o para menos significativa na express&#227;o de hsa&#8208;miR&#8208;21&#8208;5p&#44; hsa&#8208;miR&#8208;142&#8208;3p&#44; hsa&#8208;miR&#8208;424&#8208;5p&#44; hsa&#8208;miR&#8208;223&#8208;3p&#44; hsa&#8208;miR&#8208;26a&#8208;5p&#44; hsa&#8208;miR&#8208;106b&#8208;5p&#44; hsa&#8208;miR&#8208;126&#8208;5p&#44; hsa&#8208;miR&#8208;181a&#8208;5p&#44; hsa&#8208;miR&#8208;222&#8208;3p&#44; hsa&#8208;miR&#8208;22&#8208;3p&#44; hsa&#8208;miR&#8208;24&#8208;3p&#44; hsa&#8208;miR&#8208;17&#8208;3p&#44; hsa&#8208;miR&#8208;30b&#8208;5p&#44; hsa&#8208;miR&#8208;130a&#8208;3p&#44; hsa&#8208;miR&#8208;30e&#8208;5p e hsa&#8208;miR&#8208;16&#8208;5p no grupo de pacientes em compara&#231;&#227;o com o grupo de controles &#40;p&#160;&#60;&#160;0&#44;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46; As Tabelas 2 e 3 tamb&#233;m apresentam as <span class="elsevierStyleItalic">fold changes</span> no grupo de pacientes em compara&#231;&#227;o com o grupo controle&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">No grupo de pacientes&#44; n&#227;o foi observada rela&#231;&#227;o significativa entre as express&#245;es de miRNA e o escore PASI&#44; o escore DLQI e o comprometimento ungueal&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discuss&#227;o</span><p id="par0075" class="elsevierStylePara elsevierViewall">A psor&#237;ase &#233; doen&#231;a inflamat&#243;ria cr&#244;nica da pele em cuja patog&#234;nese est&#227;o envolvidos queratin&#243;citos epid&#233;rmicos&#44; c&#233;lulas imunes e mediadores inflamat&#243;rios&#46; Nos &#250;ltimos anos&#44; demonstrou&#8208;se que os miRNAs regulam a diferencia&#231;&#227;o&#44; a prolifera&#231;&#227;o e a resposta de citocinas dos queratin&#243;citos&#44; a sobreviv&#234;ncia e a ativa&#231;&#227;o das c&#233;lulas T&#44; bem como a associa&#231;&#227;o entre imun&#243;citos e queratin&#243;citos&#46; Embora diferentes perfis de express&#227;o de miRNAs tenham sido relatados em pacientes com psor&#237;ase&#44; os miRNAs n&#227;o foram identificados como um biomarcador para diagn&#243;stico&#44; atividade e gravidade da doen&#231;a na pr&#225;tica cl&#237;nica&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">17</span></a> Embora a maioria dos pacientes inclu&#237;dos no presente estudo apresentasse doen&#231;a mais leve&#44; foi observada regula&#231;&#227;o regula&#231;&#227;o para cima e para baixo na express&#227;o de miRNA em amostras de soro de pacientes com psor&#237;ase&#59; os presentes achados s&#227;o compat&#237;veis com os dados da literatura existente em amostras de soro e pele de pacientes com psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">18&#8211;20</span></a> No entanto&#44; no presente estudo&#44; essas express&#245;es de miRNA n&#227;o estavam significativamente associadas ao escore PASI&#44; DLQI e comprometimento ungueal&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Foi demonstrado que muitos miRNAs que envolvem miR&#8208;203 e miR&#8208;125b desempenham pap&#233;is&#8208;chave na resposta inflamat&#243;ria&#44; disfun&#231;&#227;o imunol&#243;gica e doen&#231;as hiperproliferativas&#44; inclusive psor&#237;ase&#46; Sugere&#8208;se que os miRNAs detectados em amostras de sangue podem ser biomarcadores no diagn&#243;stico&#44; progn&#243;stico e resposta ao tratamento&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">21</span></a> No presente estudo&#44; embora o miR&#8208;146a e o miR125b tenham sido regulados para cima e para baixo nos pacientes com psor&#237;ase&#44; respectivamente&#44; a associa&#231;&#227;o n&#227;o foi estatisticamente significativa&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">A express&#227;o de diversos miRNAs foi relacionada &#224; atividade ou gravidade da psor&#237;ase em v&#225;rios estudos&#46; No estudo de Hou RX et al&#46;&#44; verificou&#8208;se maior express&#227;o do miR&#8208;155&#8208;5p nas c&#233;lulas&#8208;tronco mesenquimais d&#233;rmicas de pacientes com psor&#237;ase&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">18</span></a> Guo et al&#46; observaram que a express&#227;o do miR&#8208;369&#8208;3p estava aumentada no soro e na pele dos pacientes com psor&#237;ase e associada &#224; atividade da doen&#231;a&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">19</span></a> Em outro estudo&#44; a express&#227;o de miR&#8208;1266&#8208;5p foi relatada como aumentada no soro de pacientes com psor&#237;ase e associada &#224; atividade da doen&#231;a&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">20</span></a> De forma semelhante&#44; no presente estudo as express&#245;es de miR&#8208;155&#8208;5p&#44; miR&#8208;369&#8208;3p e miR&#8208;1266&#8208;5p estavam significativamente aumentadas em pacientes com psor&#237;ase quando comparadas aos controles&#46; No entanto&#44; nenhuma associa&#231;&#227;o estatisticamente significativa foi observada entre miRNAs e gravidade da doen&#231;a&#46; Esse resultado pode ser devido ao fato de a maioria dos pacientes apresentar psor&#237;ase leve ou moderada&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">O efeito de diversos tratamentos sist&#234;micos nas express&#245;es de miRNA e o papel dos miRNAs na patog&#234;nese da doen&#231;a foram investigados&#46; Raaby et al<span class="elsevierStyleItalic">&#46;</span> n&#227;o detectaram altera&#231;&#245;es na express&#227;o do miRNA quatro dias ap&#243;s o tratamento com adalimumabe&#44; sugeriram que o perfil de express&#227;o de citocinas n&#227;o &#233; facilitado por altera&#231;&#245;es precoces na express&#227;o do miRNA&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">22</span></a> Em contraste com o presente estudo&#44; os n&#237;veis de miR&#8208;142&#8208;3p estavam aumentados em pacientes com psor&#237;ase e diminu&#237;ram com o tratamento com etanercepte no estudo de Pivarcsi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">23</span></a> Ich&#305;hara et al<span class="elsevierStyleItalic">&#46;</span> encontraram uma express&#227;o diminu&#237;da de miR&#8208;424 nos tecidos de pacientes com psor&#237;ase e observaram que a diminui&#231;&#227;o da express&#227;o de miR&#8208;424 associada a n&#237;veis aumentados de MEK1 e ciclina E1 pode induzir a prolifera&#231;&#227;o de queratin&#243;citos na epiderme&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a> Da mesma maneira&#44; no presente estudo&#44; a express&#227;o do miR&#8208;424 estava regulada para baixo em pacientes com psor&#237;ase quando comparada aos controles&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Estudos sobre miRNAs e outras doen&#231;as cr&#244;nicas tamb&#233;m podem ser &#250;teis para entender a patog&#234;nese e o efeito dos tratamentos sist&#234;micos na psor&#237;ase&#46; Em um estudo feito em pacientes com artrite reumatoide&#44; Xiang et al<span class="elsevierStyleItalic">&#46;</span> observaram que a express&#227;o aumentada de miR&#8208;498 suprimia a diferencia&#231;&#227;o de c&#233;lulas Th17&#44; ao focar em STAT3&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">25</span></a> Em outro estudo de Wang et al&#46;&#44; foi demonstrado que miR&#8208;223 causava doen&#231;a inflamat&#243;ria intestinal pela via IL23&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">26</span></a> Sabe&#8208;se que a via IL23&#47;17 desempenha um papel fundamental na patog&#234;nese da psor&#237;ase&#59; tratamentos contra essa via&#44; como o anti&#8208;IL17 &#40;secuquinumabe&#41;&#44; s&#227;o eficazes no tratamento da psor&#237;ase&#46;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">27&#44;28</span></a> Consequentemente&#44; a superexpress&#227;o do miR&#8208;498 pode ser eficaz no tratamento da psor&#237;ase pela via IL17&#46; Embora os autores n&#227;o tenham investigado as express&#245;es de miRNA antes e ap&#243;s os tratamentos&#44; observou&#8208;se uma express&#227;o significativamente aumentada de miR&#8208;498 em pacientes com psor&#237;ase&#46; Em outro estudo&#44; An et al<span class="elsevierStyleItalic">&#46;</span> demonstraram que a suprarregula&#231;&#227;o do miR&#8208;205 inibe o desenvolvimento de queloide&#44; suprime a produ&#231;&#227;o do fator de crescimento do endot&#233;lio vascular &#40;VEGF&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">29</span></a> Chamorro&#8208;Jorganes et al&#46; relataram que o VEGF estimula as c&#233;lulas endoteliais para a angiog&#234;nese por indu&#231;&#227;o do miR&#8208;17&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">30</span></a> Como &#233; sabido que o VEGF est&#225; envolvido na patog&#234;nese da psor&#237;ase&#44; esses relatos respaldam a hip&#243;tese de que a express&#227;o de miR&#8208;205 e miR&#8208;17 pode afetar o desenvolvimento da psor&#237;ase via VEGF&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">31</span></a> No presente estudo&#44; enquanto a express&#227;o de miR&#8208;205&#8208;5p estava significativamente regulada para cima&#44; a express&#227;o de mir&#8208;17&#8208;3p estava significativamente regulada para baixo em pacientes com psor&#237;ase quando comparada aos controles&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">V&#225;rios tipos de miRNA est&#227;o envolvidos na patog&#234;nese de diversos tipos de psor&#237;ase&#46; Enquanto a via IL23&#47;Th17 &#233; respons&#225;vel pelo desenvolvimento da psor&#237;ase vulgar&#44; IL&#8208;1&#44; IL&#8208;36 e IL&#8208;6 s&#227;o citocinas envolvidas no desenvolvimento da psor&#237;ase pustulosa&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">32</span></a> Chyi&#8208;Ying et al<span class="elsevierStyleItalic">&#46;</span> relataram que o miR&#8208;26 reduz a IL&#8208;6&#44; que &#233; ativada pelo TNF&#8208;&#945;&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">33</span></a> MiR&#8208;26 pode estar envolvido no desenvolvimento de psor&#237;ase mediada por IL&#8208;6&#46; Os medicamentos que suprimem a libera&#231;&#227;o de IL&#8208;6&#44; como o tocilizumabe&#44; s&#227;o usados no tratamento da artrite reumatoide e da artrite reumatoide juvenil e est&#227;o entre as poss&#237;veis op&#231;&#245;es de tratamento futuro da psor&#237;ase pustulosa&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">32</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">O transdutor de sinal e ativa&#231;&#227;o da transcri&#231;&#227;o &#40;STAT3&#41; foi apontado recentemente como um ator&#8208;chave na patog&#234;nese da psor&#237;ase e de condi&#231;&#245;es inflamat&#243;rias similares &#224; psor&#237;ase&#46; Relata&#8208;se que a hiperatividade do STAT3 &#233; uma mediadora da sinaliza&#231;&#227;o da maioria das citocinas&#44; inclusive a interleucina IL&#8208;23&#47;IL&#8208;17&#44; e &#233; observada em quase todos os tipos de c&#233;lulas envolvidas no surgimento da doen&#231;a&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">34</span></a> Maimaiti et al<span class="elsevierStyleItalic">&#46;</span> apontaram que o miR&#8208;106b modula a angiog&#234;nese em c&#233;lulas endoteliais e afeta a express&#227;o de STAT3&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">35</span></a> Em outro estudo&#44; foi demonstrado que o STAT3 inibe a express&#227;o de miR&#8208;22 em pacientes com linfoma cut&#226;neo de c&#233;lulas T&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">36</span></a> Assim&#44; o miR&#8208;22 pode ser inibido pela patog&#234;nese mediada por STAT3 na psor&#237;ase&#46; No presente estudo&#44; as express&#245;es de miR&#8208;106b&#8208;5p e miR&#8208;22 foram significativamente reguladas para cima e para baixo nos pacientes com psor&#237;ase&#44; respectivamente&#44; respaldando esses achados&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">O presente estudo tem algumas limita&#231;&#245;es&#58; apenas pacientes com psor&#237;ase leve a moderada foram inclu&#237;dos e a maioria estava em tratamento t&#243;pico&#59; portanto&#44; n&#227;o foi poss&#237;vel avaliar as altera&#231;&#245;es na express&#227;o de miRNA antes e ap&#243;s tratamentos sist&#234;micos&#46; Al&#233;m disso&#44; os pacientes atuais apresentavam psor&#237;ase do tipo placa e&#44; portanto&#44; a express&#227;o de miRNA n&#227;o foi avaliada em outros tipos de psor&#237;ase&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclus&#227;o</span><p id="par0115" class="elsevierStylePara elsevierViewall">O presente estudo incluiu pacientes com psor&#237;ase leve a moderada e avaliou miRNAs de amostras de sangue em vez de les&#245;es cut&#226;neas&#59; um determinado conjunto de miRNAs estava regulado para mais ou para menos nos pacientes com psor&#237;ase&#44; um achado compat&#237;vel com a literatura existente&#46; Portanto&#44; os presentes resultados confirmam mais uma vez o papel dos miRNAs na patog&#234;nese da psor&#237;ase&#46; No entanto&#44; n&#227;o foi observada associa&#231;&#227;o entre a express&#227;o de miRNA e o escore PASI&#44; o escore DLQI e o comprometimento ungueal nos pacientes&#46; Estudos adicionais devem ser feitos para entender melhor se os miRNAs podem ser usados como um marcador para o progn&#243;stico da psor&#237;ase&#44; qual miRNA &#233; mais espec&#237;fico para cada tipo de psor&#237;ase e se os miRNAs podem ser usados no tratamento da psor&#237;ase no futuro&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Suporte financeiro</span><p id="par0120" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Contribui&#231;&#227;o dos autores</span><p id="par0125" class="elsevierStylePara elsevierViewall">Emine Tugba Alatas&#58; Concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Murat Kara&#58; An&#225;lise estat&#237;stica&#59; concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Gursoy Dogan&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Asl&#305; Ak&#305;n Belli&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflitos de interesse</span><p id="par0145" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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            0 => "Biomarcadores farmacol&#243;gicos"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Em estudos recentes&#44; os microRNAs &#40;miRNAs&#41; demonstraram desempenhar um papel importante na patog&#234;nese da psor&#237;ase&#46; No entanto&#44; a literatura apresenta poucos estudos que avaliem miRNAs no sangue de pacientes com psor&#237;ase&#44; inclusive um grande n&#250;mero de pain&#233;is de miRNA&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar a express&#227;o de miRNA em amostras de sangue de pacientes com psor&#237;ase&#44; bem como avaliar a associa&#231;&#227;o entre a express&#227;o de miRNA e a gravidade da psor&#237;ase&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo de caso controle em 52 pacientes com psor&#237;ase vulgar e 54 controles&#46; O hist&#243;rico m&#233;dico dos pacientes&#44; os escores do &#205;ndice de Gravidade da Psor&#237;ase por &#193;rea &#40;PASI&#41; e do &#205;ndice de Qualidade de Vida em Dermatologia &#40;DLQI&#44; do ingl&#234;s <span class="elsevierStyleItalic">Dermatology Life Quality Index</span>&#41; foram registrados&#46; Os 42 <span class="elsevierStyleItalic">primers</span> de miRNA relacionados &#224; doen&#231;a foram avaliados por PCR em tempo real&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No grupo de pacientes&#44; 13&#44;4&#37; apresentaram comprometimento ungueal e 8&#44;2&#37; apresentaram artrite psori&#225;sica&#46; Os escores m&#233;dios do PASI e DLQI foram 7&#44;90 &#177; 8&#44;83 e 8&#44;13 &#177; 5&#44;50&#44; respectivamente&#46; Entre os 42 primers de miRNA&#44; as express&#245;es de hsa&#8208;miR&#8208;155&#8208;5p&#44; hsa&#8208;miR&#8208;369&#8208;3p&#44; hsa&#8208;miR&#8208;193b&#8208;3p&#44; hsa&#8208;miR&#8208;498&#44; hsa&#8208;miR&#8208;1266&#8208;5p&#44; hsa&#8208;let&#8208;7d&#8208;5p&#44; hsa&#8208;miR&#8208;205&#8208;5p&#44; hsa&#8208;let&#8208;7c&#8208;5p&#44; hsa&#8208;miR&#8208;30b&#8208;3p e hsa&#8208;miR&#8208;515&#8208;3p estavam significativamente reguladas para cima&#44; enquanto as express&#245;es de hsa&#8208;miR&#8208;21&#8208;5p&#44; hsa&#8208;miR&#8208;142&#8208;3p&#44; hsa&#8208;miR&#8208;424&#8208;5p&#44; hsa&#8208;miR&#8208;223&#8208;3p&#44; hsa&#8208;miR&#8208;26a&#8208;5p&#44; hsa&#8208;miR&#8208;106b&#8208;5p&#44; hsa&#8208;miR&#8208;126&#8208;5p&#44; hsa&#8208;miR&#8208;181a&#8208;5p&#44; hsa&#8208;miR&#8208;222&#8208;3p&#44; hsa&#8208;miR&#8208;22&#8208;3p&#44; hsa&#8208;miR&#8208;24&#8208;3p&#44; hsa&#8208;miR&#8208;17&#8208;3p&#44; hsa&#8208;miR&#8208;30b&#8208;5p&#44; hsa&#8208;miR&#8208;130a&#8208;3p&#44; hsa&#8208;miR&#8208;30e&#8208;5p e hsa&#8208;miR&#8208;16&#8208;5p estavam significativamente reguladas para baixo em pacientes com psor&#237;ase em compara&#231;&#227;o ao grupo controle &#40;p &#60; 0&#44;05&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Uma vez que o estudo incluiu pacientes com psor&#237;ase leve a moderada&#44; que na maioria das vezes s&#243; receberam tratamentos t&#243;picos&#44; as altera&#231;&#245;es nos miRNAs antes e depois dos tratamentos sist&#234;micos n&#227;o foram avaliadas&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A detec&#231;&#227;o de regula&#231;&#227;o para cima ou para baixo na express&#227;o de 24 miRNA em pacientes com psor&#237;ase&#44; mesmo naqueles com doen&#231;a mais leve&#44; respalda ainda mais o papel dos miRNAs na patog&#234;nese da psor&#237;ase&#46; Estudos futuros devem esclarecer se os miRNAs podem ser usados como um marcador para o progn&#243;stico da psor&#237;ase ou como um agente terap&#234;utico no tratamento da psor&#237;ase&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Alatas ET&#44; Kara M&#44; Dogan G&#44; Belli AA&#46; Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity&#46; An Bras Dermatol&#46; 2020&#59;95&#58;702&#8211;7&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Trabalho realizado no Departamento de Dermatologia&#44; University of Mu&#287;la S&#305;tk&#305; Ko&#231;man&#44; Mugla&#44; Turquia&#46;</p>"
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                  \t\t\t\t">43&#44;53 &#177; 16&#44;52&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Acitretina &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Ciclosporina &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Artrite psori&#225;tica &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprometimento ungueal &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">PASI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">DLQI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#44;13 &#177; 5&#44;50&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2467468.png"
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas sociodemogr&#225;ficas e par&#226;metros bioqu&#237;micos dos grupos pacientes e controles</p>"
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          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#916;&#44; Delta&#59; &#708;&#44; regula&#231;&#227;o para mais &#40;vermelho&#41;&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Valores de <span class="elsevierStyleItalic">fold change</span> e <span class="elsevierStyleItalic">fold regulation</span> maiores que 2 est&#227;o apresentados em vermelho&#46;</p>"
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                  \t\t\t\t" scope="col">miRNA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">hsa&#8208;miR&#8208;369&#8208;3p&nbsp;\t\t\t\t\t\t\n
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2467469.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">miRNAs com express&#227;o regulada para mais nos grupos de pacientes e de controles</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">&#916;&#44; Delta&#59; &#709;&#44; regula&#231;&#227;o para menos &#40;azul&#41;&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Valores de <span class="elsevierStyleItalic">fold change</span> menores que 0&#44;5 s&#227;o indicados em azul&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
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                0 => """
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                  \t\t\t\t" scope="col">miRNA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controle</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Psor&#237;ase vulgar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;n &#61; 22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2<span class="elsevierStyleSup">&#8743;</span>&#40;&#8208;M&#233;d&#46; &#40;&#916;&#916;Ct&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2<span class="elsevierStyleSup">&#8743;</span>&#40;&#8208;M&#233;d&#46; &#40;&#916;&#916;Ct&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fold change&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">valor&#8208;p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;21&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;193773&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;045936&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2371&#709;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;00039&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;125b&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;053615&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;042915&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;8004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;10844&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;142&#8208;3p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;107994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;042771&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3943 &#709;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;00214&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;424&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;147849&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;043429&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2937 &#709;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;223&#8208;3p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;911406&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;066345&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0347 &#709;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;00067&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;425&#8208;3p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;709862&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;684317&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;964&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;20361&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;26a&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;060076&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;03822&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">hsa&#8208;miR&#8208;26b&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;038971&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">hsa&#8208;miR&#8208;106b&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">hsa&#8208;miR&#8208;126&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">hsa&#8208;miR&#8208;181a&#8208;5p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">hsa&#8208;miR&#8208;221&#8208;3p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">hsa&#8208;miR&#8208;222&#8208;3p&nbsp;\t\t\t\t\t\t\n
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                        "volumen" => "135"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14678257"
                            "web" => "Medline"
                          ]
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                      ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of microRNAs in cardiac preconditioning"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;N&#46; Salloum"
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                            2 => "R&#46;C&#46; Kukreja"
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                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1097/FJC.0b013e3181f581ba"
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                        "tituloSerie" => "J Cardiovasc Pharmacol&#46;"
                        "fecha" => "2010"
                        "volumen" => "56"
                        "paginaInicial" => "581"
                        "paginaFinal" => "588"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20980922"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The expanding microRNA world in psoriasis"
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                            0 => "E&#46; Sonkoly"
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                    0 => array:2 [
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                        "tituloSerie" => "Exp Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "26"
                        "paginaInicial" => "375"
                        "paginaFinal" => "376"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27992082"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Association between SNPs in pre&#8208;miRNA and risk of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;J&#46; Li"
                            1 => "L&#46;B&#46; Gao"
                            2 => "M&#46;L&#46; Lv"
                            3 => "W&#46; Dong"
                            4 => "X&#46;W&#46; Su"
                            5 => "W&#46;B&#46; Liang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinbiochem.2011.04.021"
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                        "tituloSerie" => "Clin Biochem&#46;"
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                        "paginaInicial" => "813"
                        "paginaFinal" => "816"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21565178"
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                          ]
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                          "pii" => "S1470204518301426"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Genetic polymorphisms altering microRNA activity in psoriasis &#8722; a key to solve the puzzle of missing heritability&#63;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "E&#46; Sonkoly"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/exd.12469"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol&#46;"
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                        "volumen" => "23"
                        "paginaInicial" => "620"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24917490"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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              "identificador" => "bib0235"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MicroRNA&#8208;223 and miR&#8208;143 are important systemic biomarkers for disease activity in psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "M&#46; Gyldenl&#248;ve"
                            3 => "M&#46;A&#46; R&#248;pke"
                            4 => "L&#46; Skov"
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                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jdermsci.2014.05.005"
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                        "tituloSerie" => "J Dermatol Sci&#46;"
                        "fecha" => "2014"
                        "volumen" => "75"
                        "paginaInicial" => "133"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24909097"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Regulation of pro&#8208;inflammatory cytokines TNF&#945; and IL24 by microRNA&#8208;203 in primary keratinocytes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;N&#46; Primo"
                            1 => "R&#46;O&#46; Bak"
                            2 => "B&#46; Schibler"
                            3 => "J&#46;G&#46; Mikkelsen"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cyto.2012.07.031"
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                        "tituloSerie" => "Cytokine&#46;"
                        "fecha" => "2012"
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                        "paginaInicial" => "741"
                        "paginaFinal" => "748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22917968"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Up&#8208;regulation of microRNA&#8208;210 induces immune dysfunction via targeting FOXP3 in CD4&#40;&#43;&#41; T cells of psoriasis vulgaris"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Zhao"
                            1 => "L&#46;T&#46; Wang"
                            2 => "G&#46;P&#46; Liang"
                            3 => "P&#46; Zhang"
                            4 => "X&#46;J&#46; Deng"
                            5 => "Q&#46; Tang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Immunol&#46;"
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                        "paginaInicial" => "22"
                        "paginaFinal" => "30"
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                    ]
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              "identificador" => "bib0250"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "MicroRNAs&#58; novel regulators involved in the pathogenesis of psoriasis&#63;"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Sonkoly"
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                            2 => "P&#46;C&#46; Janson"
                            3 => "A&#46; S&#228;&#228;f"
                            4 => "L&#46; Lundeberg"
                            5 => "M&#46; Tengvall-Linder"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "PLoS One&#46;"
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                        "paginaInicial" => "e610"
                      ]
                    ]
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              "identificador" => "bib0255"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A single&#8208;nucleotide polymorphism of miR&#8208;146a and psoriasis&#58; an association and functional study"
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                        0 => array:2 [
                          "etal" => true
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                            1 => "X&#46; Yi"
                            2 => "S&#46; Guo"
                            3 => "Q&#46; Shi"
                            4 => "C&#46; Wei"
                            5 => "X&#46; Li"
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                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "J Cell Mol Med&#46;"
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                        "paginaInicial" => "2225"
                        "paginaFinal" => "2234"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25209759"
                            "web" => "Medline"
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              ]
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              "identificador" => "bib0260"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "MiR&#8208;146a modulates autoreactive Th17 cell differentiation and regulates organ&#8208;specific autoimmunity"
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                        0 => array:2 [
                          "etal" => true
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                            2 => "I&#46;Y&#46; Choi"
                            3 => "Y&#46;C&#46; Wang"
                            4 => "S&#46; Liu"
                            5 => "A&#46;T&#46; Pham"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "J Clin Invest&#46;"
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                        "volumen" => "127"
                        "paginaInicial" => "3702"
                        "paginaFinal" => "3716"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28872459"
                            "web" => "Medline"
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                ]
              ]
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              "identificador" => "bib0265"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effect of narrow&#8208;band ultraviolet B phototherapy on p63 and microRNA &#40;miR&#8208;21 and miR&#8208;125b&#41; expression in psoriatic epidermis"
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                        0 => array:2 [
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                            2 => "P&#46;J&#46; Coates"
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                    0 => array:2 [
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                        "tituloSerie" => "Acta Derm Venereol&#46;"
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                        "paginaFinal" => "397"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21373745"
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                    0 => array:2 [
                      "titulo" => "Increased miR&#8208;155&#8208;5p expression in dermal mesenchymal stem cells of psoriatic patients&#58; comparing the microRNA expression profile by microarray"
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                        0 => array:2 [
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                            4 => "P&#46; An"
                            5 => "Z&#46;P&#46; Hao"
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                        "tituloSerie" => "Genet Mol Res&#46;"
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                0 => array:2 [
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                      "titulo" => "Serum and skin levels of miR&#8208;369&#8208;3p in patients with psoriasis and their correlation with disease severity"
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                            2 => "C&#46; Wei"
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                            4 => "G&#46; Zhu"
                            5 => "Q&#46; Shi"
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                        ]
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24135466"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Recent progress in studies of miRNA and skin diseases"
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                      "titulo" => "An exploration of the role of microRNAs in psoriasis&#58; a systematic review of the literature"
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                            4 => "Q&#46;C&#46; Huang"
                            5 => "C&#46;J&#46; Lu"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Changes in mRNA expression precede changes in microRNA expression in lesional psoriatic skin during treatment with adalimumab"
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                        "link" => array:1 [
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                          "etal" => false
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                            4 => "E&#46; Sonkoly"
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                      "titulo" => "microRNA&#8208;mediated keratinocyte hyperproliferation in psoriasis vulgaris"
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                            4 => "K&#46; Sakai"
                            5 => "S&#46; Masuguchi"
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                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2011.10497.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "165"
                        "paginaInicial" => "1003"
                        "paginaFinal" => "1010"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21711342"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
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              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Upregulation of miR&#8208;498 suppresses Th17 cell differentiation by targeting STAT3 in rheumatoid arthritis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;Y&#46; Xiang"
                            1 => "F&#46; Pan"
                            2 => "J&#46;Z&#46; Yan"
                            3 => "L&#46;Q&#46; Hong"
                            4 => "L&#46;H&#46; Zhang"
                            5 => "Y&#46;H&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Physiologica Sinica&#46;"
                        "fecha" => "2018"
                        "volumen" => "70"
                        "paginaInicial" => "167"
                        "paginaFinal" => "174"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29691581"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673618315599"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Wang"
                            1 => "K&#46; Chao"
                            2 => "Chien Ng"
                            3 => "A&#46;H&#46; Bai"
                            4 => "Q&#46; Yu"
                            5 => "J&#46; Yu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13059-016-0901-8"
                      "Revista" => array:5 [
                        "tituloSerie" => "Pro&#8208;inflammatory miR&#8208;223 mediates the cross&#8208;talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease Genome Biol&#46;"
                        "fecha" => "2016"
                        "volumen" => "17"
                        "paginaInicial" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27029486"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The interleukin&#8208;23&#47;interleukin&#8208;17 axis links adaptive and innate immunity in psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;P&#46; Sch&#246;n"
                            1 => "L&#46; Erpenbeck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fimmu.2018.01323"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Immunol&#46;"
                        "fecha" => "2018"
                        "volumen" => "9"
                        "paginaInicial" => "1323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29963046"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mazurek U3&#46; Anti&#945; blockers&#46; Overview of reports on the effectiveness of therapy with IL12&#47;IL23 and T and B lymphocyte inhibitors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Wcis&#322;o-Dziadecka"
                            1 => "M&#46; Zbiciak"
                            2 => "L&#46; Brzezi&#324;ska-Wcis&#322;o"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Postepy Hig Med Dosw &#40;Online&#41;"
                        "fecha" => "2016"
                        "volumen" => "70"
                        "paginaInicial" => "1198"
                        "paginaFinal" => "1205"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Upregulation of microRNA&#8208;205 suppresses vascular endothelial growth factor expression&#8208;mediated PI3K&#47;Akt signaling transduction in human keloid fibroblasts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; An"
                            1 => "S&#46; Liang"
                            2 => "C&#46; Sheng"
                            3 => "Y&#46; Liu"
                            4 => "W&#46; Yao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1535370216669839"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Biol Med &#40;Maywood&#41;&#46;"
                        "fecha" => "2017"
                        "volumen" => "242"
                        "paginaInicial" => "275"
                        "paginaFinal" => "285"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27651436"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "VEGF&#8208;induced expression of miR&#8208;17&#8208;92 cluster in endothelial cells is mediated by ERK&#47;ELK1 activation and regulates angiogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Chamorro-Jorganes"
                            1 => "M&#46;Y&#46; Lee"
                            2 => "E&#46; Araldi"
                            3 => "S&#46; Landskroner-Eiger"
                            4 => "M&#46; Fern&#225;ndez-Fuertes"
                            5 => "M&#46; Sahraei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCRESAHA.115.307408"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ Res&#46;"
                        "fecha" => "2016"
                        "volumen" => "118"
                        "paginaInicial" => "38"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26472816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum vascular endothelial growth factor receptor 3 as a potential biomarker in psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "X&#46; Hong"
                            1 => "S&#46; Jiang"
                            2 => "N&#46; Marmolejo"
                            3 => "R&#46; Vangipuram"
                            4 => "E&#46; Ramos-Rojas"
                            5 => "Y&#46; Yuan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/exd.13727"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "27"
                        "paginaInicial" => "1053"
                        "paginaFinal" => "1057"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29957828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL&#8208;6 as a druggable target in psoriasis&#58; focus on pustular variants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Saggini"
                            1 => "S&#46; Chimenti"
                            2 => "A&#46; Chiricozzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2014/964069"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol Res&#46;"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "964069"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25126586"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MiR&#8208;26 down&#8208;regulates TNF&#8208;&#945;&#47;NF&#8208;&#954;B signalling and IL&#8208;6 expression by silencing HMGA1 and MALT1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;C&#46; Chyi-Ying"
                            1 => "J&#46;T&#46; Chang"
                            2 => "H&#46; Yi-Fang"
                            3 => "S&#46; Ann-Bin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/nar/gkw205"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nucleic Acids Res&#46;"
                        "fecha" => "2016"
                        "volumen" => "44"
                        "paginaInicial" => "3772"
                        "paginaFinal" => "3787"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27025651"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis&#58; A STAT3&#8208;centric view"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Calautti"
                            1 => "L&#46; Avalle"
                            2 => "V&#46; Poli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Int J Mol Sci&#46;"
                        "fecha" => "2018"
                        "volumen" => "19"
                        "paginaInicial" => "171"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MiR&#8208;106b exhibits an anti&#8208;angiogenic function by inhibiting STAT3 expression in endothelial cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Maimaiti"
                            1 => "A&#46; Maimaiti"
                            2 => "Y&#46; Yang"
                            3 => "Y&#46; Ma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12944-016-0216-5"
                      "Revista" => array:5 [
                        "tituloSerie" => "Lipids Health Dis&#46;"
                        "fecha" => "2016"
                        "volumen" => "15"
                        "paginaInicial" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26956882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Jak3 STAT3&#44; and STAT5 inhibit expression of miR&#8208;22&#44; a novel tumor suppressor microRNA&#44; in cutaneous T&#8208;cell lymphoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;A&#46; Sibbesen"
                            1 => "K&#46;L&#46; Kopp"
                            2 => "I&#46;V&#46; Litvinov"
                            3 => "L&#46; J&#248;nson"
                            4 => "A&#46; Willerslev-Olsen"
                            5 => "S&#46; Fredholm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.18632/oncotarget.4111"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncotarget&#46;"
                        "fecha" => "2015"
                        "volumen" => "6"
                        "paginaInicial" => "20555"
                        "paginaFinal" => "20569"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26244872"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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Informação do artigo

ISSN: 26662752
Idioma original: Português

DOI:10.1016/j.abdp.2020.04.006

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