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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A preval&#234;ncia de comorbidades psiqui&#225;tricas &#233; maior e mais frequente em pacientes dermatol&#243;gicos do que na popula&#231;&#227;o em geral&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">1</span></a> Estima&#8208;se que 25&#37; a 30&#37; dos pacientes t&#234;m alguma desordem mental ou problema emocional&#44; que podem ser respons&#225;veis pela causa&#44; pela predisposi&#231;&#227;o ou pelo fator agravante da afec&#231;&#227;o cut&#226;nea&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">1&#44;2</span></a> A psicodermatologia estuda as doen&#231;as cut&#226;neas resultantes da intera&#231;&#227;o pele&#8208;mente&#44; atrav&#233;s da sua uni&#227;o com a psiquiatria&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">3</span></a> Engloba manifesta&#231;&#245;es cut&#226;neas resultantes ou agravadas por fatores psicol&#243;gicos e a avalia&#231;&#227;o dos preju&#237;zos mentais e sociais decorrentes dessas dermatoses&#46; O manejo das psicodermatoses &#233; fundamental no campo da dermatologia&#44; visto que os dermatologistas s&#227;o respons&#225;veis pela maioria dos atendimentos ambulatoriais por problemas psicocut&#226;neos&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">4</span></a> Ademais&#44; muitos desses pacientes recusam interven&#231;&#227;o psiqui&#225;trica seja pelo estigma associado &#224;s doen&#231;as mentais ou pela falta de reconhecimento do componente psicol&#243;gico na sua doen&#231;a cut&#226;nea e&#44; deixam o manejo exclusivamente ao dermatologista&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> Quando h&#225; resist&#234;ncia &#224; busca de tratamento psiqui&#225;trico&#44; o dermatologista deve apoiar seu paciente com uma posi&#231;&#227;o de n&#227;o julgamento&#44; fornecer medica&#231;&#227;o psicotr&#243;pica indicada e encorajar a avalia&#231;&#227;o com um psiquiatra como complemento&#44; e n&#227;o como um substituto para a rela&#231;&#227;o terap&#234;utica&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">O uso associado de psicof&#225;rmacos&#44; representados pelos antidepressivos&#44; antipsic&#243;ticos&#44; ansiol&#237;ticos e estabilizadores de humor&#44; torna&#8208;se essencial nesses doentes&#44; uma vez que as les&#245;es cut&#226;neas podem ser agravadas quando psicopatologias subjacentes n&#227;o s&#227;o tratadas&#46; Dessa forma&#44; o conhecimento e a seguran&#231;a em prescrever os psicotr&#243;picos mais usados auxiliam no manejo dos sintomas psiqui&#225;tricos associados com dermatoses&#44; como tamb&#233;m no manejo de sintomas dermatol&#243;gicos desencadeados por s&#237;ndromes psiqui&#225;tricas&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Situa&#231;&#245;es cl&#237;nicas em que o conhecimento de psicotr&#243;picos se faz necess&#225;rio ao dermatologista&#58;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Manejo de sintomas dermatol&#243;gicos associados a enfermidades psiqui&#225;tricas&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Manejo de sintomas psiqui&#225;tricos associados a condi&#231;&#245;es dermatol&#243;gicas&#44; como fobia social nos pacientes com vitiligo&#59;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Manejo de efeitos adversos associados ao uso de psicotr&#243;picos&#59;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Manejo de outros efeitos farmacol&#243;gicos dessas medica&#231;&#245;es&#44; como&#44; por exemplo&#44; os efeitos anticolin&#233;rgico e anti&#8208;histam&#237;nico dos antidepressivos e antipsic&#243;ticos&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Classifica&#231;&#227;o das psicodermatoses</span><p id="par0040" class="elsevierStylePara elsevierViewall">As psicodermatoses podem ser classificadas em seis categorias&#58;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">1&#46;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Transtornos psicofisiol&#243;gicos&#58; compreendem dermatoses prim&#225;rias que s&#227;o exacerbadas por fatores emocionais e estresse&#46; Exemplo&#58; psor&#237;ase e dermatite at&#243;pica&#59;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">2&#46;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Transtornos psiqui&#225;tricos prim&#225;rios&#58; compreendem doen&#231;as psiqui&#225;tricas prim&#225;rias que apresentam manifesta&#231;&#245;es cut&#226;neas autoinfligidas&#44; como manifesta&#231;&#227;o secund&#225;ria a doen&#231;a psiqui&#225;trica&#46; Exemplo&#58; tricotilomania&#44; del&#237;rio de parasitose&#44; dermatite artefacta e escoria&#231;&#245;es neur&#243;ticas&#59;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">3&#46;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Transtornos psiqui&#225;tricos secund&#225;rios&#58; englobam doen&#231;as psiqui&#225;tricas que surgem como consequ&#234;ncia do impacto psicossocial decorrente de dermatoses existentes&#46; Exemplo&#58; fobia social&#44; depress&#227;o que pode surgir junto com a psor&#237;ase e a alopecia areata&#59;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">4&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Doen&#231;a cut&#226;nea sensitiva&#58; compreende sintomas psicog&#234;nicos&#44; como prurido ou queima&#231;&#227;o sem evid&#234;ncia de afec&#231;&#227;o cut&#226;nea ou outra condi&#231;&#227;o m&#233;dica&#46; Exemplo&#58; vulvodinia e glossodinia&#59;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">5&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Altera&#231;&#245;es pelo uso de drogas psicoativas para tratamento dermatol&#243;gico&#46; Exemplo&#58; prurido&#44; erup&#231;&#245;es exantem&#225;ticas e s&#237;ndrome de Stevens&#8208;Johnson&#59;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">6&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Doen&#231;as multifatoriais&#58; compreendem doen&#231;as nas quais fatores psiconeuroimunol&#243;gicos desencadeiam ou agravam condi&#231;&#245;es cut&#226;neas&#46; Exemplo&#58; dermatite at&#243;pica&#44; psor&#237;ase&#44; alopecia areata&#44; prurido cr&#244;nico&#46;</p></li></ul></p><p id="par0075" class="elsevierStylePara elsevierViewall">A maioria dos pacientes com psicodermatoses encontram&#8208;se classificada nos diagn&#243;sticos psiqui&#225;tricos a seguir&#58;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> Transtornos depressivos&#59; Transtornos de ansiedade&#59; Transtornos psic&#243;ticos e transtornos de del&#237;rio&#59; Transtorno obsessivo&#8208;compulsivo e transtornos de controle de impulso&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Embora os dermatologistas n&#227;o tenham treinamento espec&#237;fico para fazer diagn&#243;sticos psiqui&#225;tricos&#44; uma s&#243;lida rela&#231;&#227;o m&#233;dico&#8208;paciente&#44; desenvolvida ao longo de v&#225;rias consultas&#44; 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Apesar de n&#227;o causarem depend&#234;ncia&#44; s&#227;o descritos sintomas ap&#243;s a descontinua&#231;&#227;o abrupta&#44; como ins&#244;nia&#44; n&#225;useas&#44; sudorese&#44; dist&#250;rbios sensoriais&#46; Para a retirada&#44; &#233; indicada a diminui&#231;&#227;o gradativa da droga por v&#225;rias semanas&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a> Considera&#8208;se permanecer com a droga por pelo menos seis meses ap&#243;s resposta terap&#234;utica&#44; antes de tentar retir&#225;&#8208;la&#44; o que minimiza os riscos de retorno dos sintomas&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;12</span></a></p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Inibidores seletivos de recapta&#231;&#227;o de serotonina</span><p id="par0095" class="elsevierStylePara elsevierViewall">Os inibidores seletivos de recapta&#231;&#227;o de serotonina &#40;ISRS&#41;&#44; listados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 1</a>&#44; inibem de forma seletiva a recapta&#231;&#227;o da serotonina&#44; aumentam&#44; assim&#44; a disponibilidade desse neurotransmissor&#44; que &#233; respons&#225;vel por influenciar o humor&#44; a cogni&#231;&#227;o&#44; o sono&#44; o apetite e o comportamento sexual&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">13</span></a> O aumento da disponibilidade da serotonina na fenda sin&#225;ptica modularia a melhoria dos sintomas da depress&#227;o baseada na teoria monoamin&#233;rgica da depress&#227;o&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Apresentam um bom perfil de seguran&#231;a e costumam apresentar maior tolerabilidade em rela&#231;&#227;o aos tric&#237;clicos&#44; s&#227;o a primeira escolha terap&#234;utica para muitos pacientes&#46; Os efeitos adversos mais relatados s&#227;o as altera&#231;&#245;es gastrointestinais &#8211; n&#225;usea e dispepsia &#8211; ins&#244;nia&#44; altera&#231;&#227;o de peso e disfun&#231;&#227;o sexual&#44; como anorgasmia e redu&#231;&#227;o de libido&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a> &#201; liberado seu uso para gestantes&#44; com prefer&#234;ncia para aqueles de meia&#8208;vida mais curta&#44; como sertralina e paroxetina&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antidepressivos tric&#237;clicos</span><p id="par0105" class="elsevierStylePara elsevierViewall">Essa classe &#233; a mais antiga dos antidepressivos&#44; f&#225;rmacos listados na <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 2</a>&#46; Atuam de forma semelhante aos ISRS&#44; aumentam a serotonina e norepinefrina na fenda sin&#225;ptica&#46; Foram substitu&#237;dos pelos ISRS ao longo dos anos&#44; pois t&#234;m mais efeito sedativo e maior quantidade de outros efeitos colaterais&#46; Entretanto&#44; esses f&#225;rmacos&#44; em especial a doxepina&#44; apresentam propriedades mais semelhantes aos anti&#8208;histam&#237;nicos e por isso s&#227;o muito usados para ins&#244;nia e prurido&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">15&#44;16</span></a> Tamb&#233;m t&#234;m boa atua&#231;&#227;o em pacientes com dores de origem neural&#46; Geralmente&#44; as doses necess&#225;rias para tratamento da dor e do prurido costumam ser menores do que as doses antidepressivas&#46; A nortriptilina tem menos efeitos adversos e deve ser escolhida para uso em idosos&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Est&#227;o descritos entre os efeitos adversos boca seca&#44; constipa&#231;&#227;o&#44; tonturas&#44; vis&#227;o turva&#44; taquicardia e reten&#231;&#227;o urin&#225;ria&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">17</span></a> Devem ser usados de forma cautelosa em pacientes portadores de doen&#231;as card&#237;acas&#44; tais como altera&#231;&#245;es de condu&#231;&#227;o&#46; H&#225; contraindica&#231;&#227;o absoluta para o uso em pacientes ap&#243;s epis&#243;dio recente &#40;at&#233;&#160;6&#160;semanas&#41; de infarto agudo do mioc&#225;rdio&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a> Podem ser usados na gesta&#231;&#227;o&#44; evita&#8208;se a prescri&#231;&#227;o no primeiro trimestre<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">18</span></a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Doxepina &#40;Sinequan&#174;&#41;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Este antidepressivo tric&#237;clico tem propriedades anti&#8208;histam&#237;nicas potentes e &#233; usado na dermatologia para pacientes com prurido cr&#244;nico e urtic&#225;ria&#44; &#233; uma op&#231;&#227;o ao uso de difenidramina e hidroxizine&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;17</span></a> Al&#233;m disso&#44; quando em formula&#231;&#227;o t&#243;pica &#40;creme&#160;5&#37;&#41;&#44; n&#227;o provoca as rea&#231;&#245;es colaterais caracter&#237;sticas dos antidepressivos tric&#237;clicos usados via oral&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">16&#44;19</span></a> As dosagens&#44; quando usados oralmente&#44; devem ser iniciadas com&#160;25&#160;mg&#47;dia e podem ser aumentadas a cada semana em&#160;10&#160;a&#160;25&#160;mg&#44; alcan&#231;am o m&#225;ximo de&#160;100&#160;mg&#47;dia&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A seda&#231;&#227;o &#233; o principal efeito adverso e pode ser necess&#225;rio ajuste nos hor&#225;rios das doses em caso de queixa do paciente&#46; Pacientes com hist&#243;ria de altera&#231;&#245;es do ritmo card&#237;aco devem ser submetidos a eletrocardiograma antes do in&#237;cio do tratamento&#46; Em casos de aumento das doses da medica&#231;&#227;o&#44; sugere&#8208;se que o exame seja repetido quando a dosagem chegar a&#160;100&#160;mg&#47;dia<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">12</span></a>&#46; Atualmente&#44; no Brasil&#44; esse medicamento encontra&#8208;se somente em farm&#225;cias de manipula&#231;&#227;o&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Outros antidepressivos</span><p id="par0125" class="elsevierStylePara elsevierViewall">Esses f&#225;rmacos antidepressivos est&#227;o citados na <a class="elsevierStyleCrossRef" href="#tbl0025">tabela 3</a>&#58;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0235" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Mirtazapina &#40;Remeron&#174;&#44; Zispin&#174;&#44; Norset&#174;&#41;</span><p id="par0135" class="elsevierStylePara elsevierViewall">Antidepressivo tetrac&#237;clico que age diretamente no aumento da quantidade de serotonina e noradrenalina&#46; Devido ao seu alto potencial de seda&#231;&#227;o e aumento de peso&#44; &#233; preferencialmente usado em pacientes terminais&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0240" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Bupropiona &#40;Wellbutrin&#174;&#44; Zetron&#174;&#41;</span><p id="par0145" class="elsevierStylePara elsevierViewall">F&#225;rmaco de recapta&#231;&#227;o seletiva de norepinefrina e dopamina&#46; Como tem menos efeitos adversos sexuais e semelhante capacidade antidepressiva&#44; ele &#233; preferido em pacientes com queixa de altera&#231;&#245;es da libido&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">12</span></a> Tamb&#233;m deve ser considerado seu uso em pacientes com dist&#250;rbios do sono&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a> &#201; necess&#225;rio o fracionamento da dose&#44; exceto nos casos de uso de comprimidos de libera&#231;&#227;o lenta&#46; &#201; uma medica&#231;&#227;o geralmente bem tolerada e tem como principais efeitos colaterais ins&#244;nia&#44; agita&#231;&#227;o&#44; dor de cabe&#231;a&#44; constipa&#231;&#227;o&#44; boca seca&#44; n&#225;useas e tremores&#46; Convuls&#245;es s&#227;o efeitos raros&#44; mas que podem ocorrer e&#44; devido a isso&#44; deve&#8208;se estar atento ao indicar uso em pacientes com hist&#243;ria de epilepsia&#46; Deve&#8208;se tamb&#233;m evitar o uso da bupropiona em pacientes com hist&#243;ria de abuso de &#225;lcool e drogas&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;16</span></a> N&#227;o &#233; recomendado uso da bupropiona na gesta&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0245" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Venlafaxina &#40;Efexor&#174;&#44; Zyvifax&#174;&#41;</span><p id="par0155" class="elsevierStylePara elsevierViewall">Medica&#231;&#227;o liberada oficialmente para uso em depress&#227;o e ansiedade&#44; a venlafaxina parece atuar na recepta&#231;&#227;o de serotonina e noradrenalina&#46; Recomenda&#8208;se o in&#237;cio da medica&#231;&#227;o com doses de&#160;75&#160;mg&#47;dia&#44; com aumento a cada duas semanas&#44; chega&#8208;se a uma dose m&#225;xima de&#160;300&#160;mg&#47;dia que deve ser dividida em duas tomadas&#46; Os efeitos adversos mais comumente relatados desse f&#225;rmaco s&#227;o ins&#244;nia e ansiedade e a press&#227;o arterial deve ser monitorada quando usada em doses altas&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">14&#44;15</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">A respeito do uso na gesta&#231;&#227;o&#44; apesar de n&#227;o ter estudos em gestantes&#44; experimentos com animais n&#227;o demonstraram teratogenicidade&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">18</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Antipsic&#243;ticos</span><p id="par0165" class="elsevierStylePara elsevierViewall">Os antipsic&#243;ticos&#44; relacionados na <a class="elsevierStyleCrossRef" href="#tbl0030">tabela 4</a>&#44; s&#227;o antagonistas dos receptores de dopamina&#44; atuam principalmente no bloqueio dos receptores do subtipo D2&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">20</span></a> S&#227;o divididos em antipsic&#243;ticos t&#237;picos &#8211; pimozida&#44; clorpromazina e haloperidol &#8211; e antipsic&#243;ticos at&#237;picos &#8211; risperidona&#44; olanzapina&#44; sulpiride e quetiapina&#46; Os at&#237;picos t&#234;m menor afinidade pelos receptores D2&#44; portanto t&#234;m menor incid&#234;ncia de efeitos extrapiramidais&#44; como distonia e parkinsonismo&#44; do que os antipsic&#243;ticos t&#237;picos&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0170" class="elsevierStylePara elsevierViewall">As principais vias dopamin&#233;rgicas no sistema nervoso central s&#227;o&#58; mesocorticol&#237;mbica&#44; nigroestriatal e t&#250;bero&#8208;infundibular&#46; Disfun&#231;&#245;es na via mesocorticol&#237;mbica est&#227;o associadas &#224; psicose&#44; esquizofrenia e transtorno do d&#233;ficit de aten&#231;&#227;o&#59; disfun&#231;&#245;es na via nigroestriatal est&#227;o relacionadas com a doen&#231;a de Parkinson e tamb&#233;m com efeitos colaterais motores quando usada como terapia dopamin&#233;rgica&#44; inclusive efeitos extrapiramidais&#46; J&#225; as disfun&#231;&#245;es na via t&#250;bero&#8208;infundibular provocam altera&#231;&#245;es na secre&#231;&#227;o de prolactina&#44; podem ocasionar galactorreia e amenorreia &#8211; uma vez que a dopamina &#233; respons&#225;vel por inibir a secre&#231;&#227;o de prolactina&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">13</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Os antipsic&#243;ticos podem provocar efeitos colaterais decorrentes da liga&#231;&#227;o a outros receptores&#44; como ganho de peso &#40;receptores histam&#237;nicos&#41;&#44; hipotens&#227;o ortost&#225;tica &#40;&#945;&#8208;adren&#233;rgicos&#41;&#44; constipa&#231;&#227;o e xerostomia &#40;receptores muscar&#237;nicos&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">20</span></a> Tamb&#233;m podem aumentar o risco de infarto mioc&#225;rdico e eventos isqu&#234;micos transit&#243;rios em pacientes idosos&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Na dermatologia&#44; os antipsic&#243;ticos podem ser usados principalmente nos transtornos delirantes&#44; t&#234;m como principal exemplo o del&#237;rio de parasitose e a dermatite artefacta&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">17</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">O haloperidol &#233; o f&#225;rmaco mais bem estudado em rela&#231;&#227;o ao uso na gesta&#231;&#227;o&#44; &#233; o antipsic&#243;tico de uso preferencial nessas pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">21</span></a></p><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pimozida &#40;Orap&#174;&#41;</span><p id="par0190" class="elsevierStylePara elsevierViewall">Esse f&#225;rmaco &#233; o antipsic&#243;tico de primeira gera&#231;&#227;o mais usado em psicodermatologia&#46; Age como antagonista potente do receptor central de dopamina&#46; &#201; indicado iniciar com&#160;1&#160;mg&#47;dia&#44; com aumento progressivo a cada duas semanas&#44; at&#233; chegar &#224; dose&#8208;alvo&#44; estabelecida entre&#160;2&#160;e&#160;6&#160;mg&#47;dia&#46; A dosagem deve ser mantida por pelo menos um m&#234;s ap&#243;s o alcance da melhoria dos sintomas&#46; Mesmo que raros&#44; devido &#224; baixa dose usada para doen&#231;as cut&#226;neas&#44; h&#225; efeitos adversos citados na literatura que incluem acatisia&#44; rigidez muscular e sensa&#231;&#227;o de inquieta&#231;&#227;o&#46; Devido &#224; possibilidade de altera&#231;&#227;o de intervalo QT&#44; &#233; recomendado eletrocardiograma em pacientes com hist&#243;ria de doen&#231;a card&#237;aca antes do in&#237;cio do tratamento&#46; Nos pacientes jovens&#47;h&#237;gidos&#44; ainda &#233; controversa a necessidade do exame eletrocardiogr&#225;fico&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">16</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Risperidona &#40;Risperdal&#174;&#44; Riss&#174;&#41;</span><p id="par0195" class="elsevierStylePara elsevierViewall">Principal medica&#231;&#227;o usada para del&#237;rio de parasitoses&#44; a risperidona &#233; um antipsic&#243;tico de nova gera&#231;&#227;o e deve ser iniciada numa dose de&#160;0&#44;5&#160;mg antes de dormir&#44; deve ser aumentada em semanas at&#233; chegar a uma dose m&#225;xima de&#160;4&#160;mg&#47;dia&#46; Pode ocasionar hiperprolactinemia e&#44; consequentemente&#44; galactorreia&#44; amenorreia e disfun&#231;&#245;es sexuais&#46; Demais efeitos adversos&#44; como a seda&#231;&#227;o&#44; s&#227;o poucos comuns e geralmente se resolvem nos primeiros dias&#46; Essa medica&#231;&#227;o tamb&#233;m deve ser usada com cautela em pacientes com hist&#243;ria de anormalidades no eletrocardiograma&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;22</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Olanzapina &#40;Zyprexa&#174;&#44; Zopix&#174;&#41;</span><p id="par0200" class="elsevierStylePara elsevierViewall">A olanzapina &#233; recomendada em doses baixas para doen&#231;as psicocut&#226;neas&#46; Sugere&#8208;se iniciar com uma dose de&#160;5&#8208;10&#160;mg&#47;dia at&#233; chegar numa dose alvo de&#160;15&#160;mg&#47;dia&#46; Apesar de ser uma medica&#231;&#227;o geralmente bem tolerada&#44; tem como principal efeito adverso o ganho de peso e consequentemente s&#237;ndrome metab&#243;lica e aumento do risco cardiovascular&#46; Em fun&#231;&#227;o disso&#44; &#233; necess&#225;rio controle do peso&#44; monitoramento de press&#227;o arterial&#44; glicose e lipidograma durante o tratamento com essa medica&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;14&#44;17</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Quetiapina &#40;Seroquel&#174;&#44; Quetrox&#174;&#44; Queropax&#174;&#41;</span><p id="par0205" class="elsevierStylePara elsevierViewall">A quetiapina &#233; bem indicada nos casos de pacientes resistentes aos tratamentos anteriores e nos pacientes idosos&#46; No tratamento de psicoses n&#227;o dermatol&#243;gicas&#44; &#233; prescrita inicialmente com&#160;25&#160;mg duas vezes ao dia e aumentada at&#233;&#160;750&#160;mg&#47;dia&#46; No entanto&#44; para uso dermatol&#243;gico &#233; recomendada redu&#231;&#227;o da dose de in&#237;cio e de manuten&#231;&#227;o&#46; A dosagem de&#160;150&#160;mg fracionada em duas tomadas &#233; indicada para o tratamento de del&#237;rio de parasitose&#44; por exemplo&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;23</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">Aumento de peso&#44; sonol&#234;ncia e hipotens&#227;o ortost&#225;tica est&#227;o entre os efeitos colaterais mais relatados&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;14</span></a></p></span><span id="sec0250" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Aripiprazol &#40;Aristab&#174;&#44; Abilify&#174;&#41;</span><p id="par0220" class="elsevierStylePara elsevierViewall">&#201; um antipsic&#243;tico de nova gera&#231;&#227;o&#44; &#233; diferenciado pela baixa rela&#231;&#227;o com dist&#250;rbios metab&#243;licos e efeitos colin&#233;rgicos&#46; Tem sido usado para pacientes com del&#237;rio de parasitose e escoria&#231;&#245;es neur&#243;ticas&#44; com bons resultados com doses entre&#160;2&#8211;30&#160;mg&#47;dia&#46; Geralmente n&#227;o causa altera&#231;&#245;es no peso&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a></p></span><span id="sec0255" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ziprasidona &#40;Geodon&#174;&#41;</span><p id="par0230" class="elsevierStylePara elsevierViewall">Tamb&#233;m &#233; um antipsic&#243;tico de nova gera&#231;&#227;o&#44; como o aripiprazol&#46; Diferencia&#8208;se dos demais por n&#227;o ter efeitos anticolin&#233;rgicos e por baixa propens&#227;o a s&#237;ndrome metab&#243;lica&#44; al&#233;m de baixa incid&#234;ncia de efeitos sedativos&#46; Entretanto&#44; tem mais riscos de altera&#231;&#227;o no intervalo QT do que os outros antipsic&#243;ticos at&#237;picos&#46; &#201; usado com sucesso no tratamento de pacientes com del&#237;rio de parasitoses com doses que variam entre&#160;20&#8211;80&#160;mg&#47;duas vezes ao dia&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Estabilizadores do humor</span><p id="par0235" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#44; como as drogas antiepil&#233;ticas e o l&#237;tio&#44; s&#227;o aprovados para uso em transtorno bipolar e em epilepsia&#46; Seus mecanismos n&#227;o est&#227;o completamente elucidados&#44; mas acredita&#8208;se que tenham a&#231;&#227;o no sistema nervoso central com o poder de controle da excita&#231;&#227;o neuronal&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a></p><p id="par0240" class="elsevierStylePara elsevierViewall">Muitas dessas medica&#231;&#245;es&#44; conforme citadas na <a class="elsevierStyleCrossRef" href="#tbl0035">tabela 5</a>&#44; s&#227;o usadas em dor neurop&#225;tica cut&#226;nea e s&#227;o tamb&#233;m eficazes no manejo do prurido cr&#244;nico&#44; al&#233;m de outros dist&#250;rbios sensoriais cut&#226;neos&#44; como as dermatoses autoinduzidas&#46; Principalmente devido ao seu poder de controle de compuls&#227;o&#44; s&#227;o inclu&#237;das no tratamento das dermatoses relacionadas &#224; autoescoria&#231;&#227;o&#44; como prurigo nodular e l&#237;quen simples cr&#244;nico&#44; e as les&#245;es autoinflingidas&#44; como tricotilomania e dermatite artefacta&#46; Essas medica&#231;&#245;es s&#227;o sabidamente teratog&#234;nicas e devem ser evitadas&#44; se poss&#237;vel&#44; em pacientes do sexo feminino em idade f&#233;rtil&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a></p><elsevierMultimedia ident="tbl0035"></elsevierMultimedia><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">L&#237;tio &#40;Carbolitium&#174;&#41;</span><p id="par0245" class="elsevierStylePara elsevierViewall">O carbonato de l&#237;tio&#44; usado no tratamento do transtorno bipolar e depress&#227;o grave&#44; age na altera&#231;&#227;o do metabolismo das catecolaminas neuronais&#46; Deve&#8208;se manter acompanhamento com dosagem do l&#237;tio s&#233;rico inicialmente a cada&#160;60&#8208;90&#160;dias&#44; pode&#8208;se estender esse intervalo at&#233;&#160;6&#160;meses&#44; conforme o tempo de uso&#46; As amostras de sangue devem ser colhidas&#160;8&#160;a&#160;12&#160;horas ap&#243;s a ingest&#227;o da dose anterior e antes da dose seguinte&#46; Recomenda&#8208;se a manuten&#231;&#227;o da litemia entre 0&#44;5&#8208;1&#44;0&#160;mEq&#47;L&#44; o equivalente a dose de&#160;600&#8211;900&#160;mg&#47;dia&#46; Sinais de toxicidade podem come&#231;ar a aparecer j&#225; com&#160;1&#44;0&#8211;1&#44;5&#160;mEq&#47;L&#46; Requer tamb&#233;m monitoramento frequente de fun&#231;&#245;es renais e tireoidiana&#46; Devemos estar atentos quanto ao uso do l&#237;tio&#44; devido ao seu alto &#237;ndice de efeitos adversos cut&#226;neos&#44; como a pioria ou o gatilho para in&#237;cio de psor&#237;ase e acne&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;24&#44;25</span></a> O l&#237;tio &#233; indicado no controle do comportamento impulsivo de pacientes com tricotilomania&#44; devido &#224; alta associa&#231;&#227;o com transtorno obsessivo compulsivo&#44; as doses variam entre&#160;900&#8211;1&#46;500&#160;mg&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;26</span></a> Pacientes com <span class="elsevierStyleItalic">skin</span><span class="elsevierStyleItalic">picking</span> tamb&#233;m podem beneficiar&#8208;se do uso do l&#237;tio para o controle do impulso&#44; embora n&#227;o haja uma dose especificada na literatura&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Lamotrigina &#40;Lamitor&#174;&#44; Lamictal&#174;&#41;</span><p id="par0250" class="elsevierStylePara elsevierViewall">&#201; uma medica&#231;&#227;o usada para tratamento de crises convulsivas&#46; Age farmacologicamente nos canais de s&#243;dio neuronais&#44; estabiliza as membranas e inibe a libera&#231;&#227;o de glutamato&#44; principalmente&#46; Foi demonstrado benef&#237;cio no uso para <span class="elsevierStyleItalic">skin</span> picking&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a>&#46; As doses citadas na literatura variam entre&#160;12&#44;5&#8211;300&#160;mg&#47;dia&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Carbamazepina &#40;Tegretol&#174;&#44; Tegrezin&#174;&#44; Tegretard&#174;&#44; Tegrex&#174;&#44; Carmazin&#174;&#41;</span><p id="par0255" class="elsevierStylePara elsevierViewall">A carbamazepina&#44; mesmo que n&#227;o se tenha completamente compreendida sua a&#231;&#227;o&#44; sabe&#8208;se que estabiliza a membrana nervosa hiperexcitada&#46; &#201; indicada para o tratamento de epilepsia&#44; transtorno bipolar&#44; depress&#227;o e dor de origem neural&#46; Na dermatologia&#44; podemos destacar o uso dessa medica&#231;&#227;o em neuralgia p&#243;s&#8208;herp&#233;tica&#46; Recomenda&#8208;se&#44; al&#233;m do fracionamento&#44; iniciar com doses mais baixas com aumento progressivo&#46; A dose recomendada para dor neurop&#225;tica &#233; de&#160;600&#8211;1200&#160;mg&#47;dia&#46; Efeitos adversos como sintomas gastrointestinais&#44; tonturas e vis&#227;o turva est&#227;o relatados&#44; como tamb&#233;m efeitos cut&#226;neos&#44; relatados a seguir no texto&#46; Riscos mais raros&#44; como agranulocitose e anemia apl&#225;sica&#44; est&#227;o relatados na literatura&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a></p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Valproato de s&#243;dio &#40;Depakote&#174;&#44; Depakene&#174;&#44; Zyvalprex&#174;&#41;</span><p id="par0260" class="elsevierStylePara elsevierViewall">A atividade do valproato de s&#243;dio&#44; que se converte em &#225;cido valproico no organismo&#44; parece ter rela&#231;&#227;o com o aumento do GABA no sistema nervoso central&#46; As doses indicadas para epilepsia iniciam&#8208;se com&#160;10&#160;a&#160;15&#160;mg&#47;kg&#47;dia&#44; podem ser aumentadas em&#160;5&#160;a&#160;10&#160;mg&#47;kg&#47;dia semanalmente&#46; Considera&#8208;se que doses abaixo de&#160;60&#160;mg&#47;kg&#47;dia t&#234;m boa resposta cl&#237;nica&#46; Para dor neurop&#225;tica as refer&#234;ncias sugerem doses entre&#160;250&#160;e&#160;1500&#160;mg&#47;dia com dose fracionada&#46; Al&#233;m dos usos na dor cr&#244;nica&#44; existem relatos de tratamentos com valproato de s&#243;dio em pacientes com nevos epid&#233;rmicos verrucosos inflamat&#243;rios &#40;NEVIL&#41;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a>&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Topiramato &#40;Amato&#174;&#44; Sigmax&#174;&#41;</span><p id="par0265" class="elsevierStylePara elsevierViewall">Medica&#231;&#227;o anticonvulsivante com m&#250;ltiplos mecanismos de redu&#231;&#227;o de hiperexcitabilidade neuronal usada no tratamento da epilepsia e profilaxia de enxaqueca&#46; Recomenda&#8208;se iniciar com&#160;25&#8211;50&#160;mg por dia por pelo menos uma semana e aumentar a dose a cada uma ou duas semanas&#46; Tem uma dose di&#225;ria entre&#160;200 e&#160;400&#160;mg&#47;dia e tem como dose m&#225;xima&#160;1600&#160;mg&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;24</span></a> Existem relatos do uso do topiramato em tratamento de tricotilomania&#44; s&#227;o necess&#225;rios estudos com popula&#231;&#245;es maiores para confirma&#231;&#227;o de efic&#225;cia&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">26</span></a></p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Pr&#233;&#8208;gabalina &#40;Lyrica&#174;&#41;</span><p id="par0270" class="elsevierStylePara elsevierViewall">Essa medica&#231;&#227;o tem nos canais de c&#225;lcio neuronais o seu mecanismo de a&#231;&#227;o&#46; Tem em sua bula indica&#231;&#227;o formal para dor neurop&#225;tica&#44; epilepsia e fibromialgia&#46; A pr&#233;&#8208;gabalina tem boa a&#231;&#227;o no controle da dor neurop&#225;tica e bom perfil de seguran&#231;a por interagir com poucos f&#225;rmacos em compara&#231;&#227;o com as outras medica&#231;&#245;es dessa classe&#46; Alguns autores indicam seu uso tamb&#233;m para prurido ur&#234;mico&#46; Indica&#8208;se uma dose de&#160;300&#8211;600&#160;mg&#47;dia&#46; Geralmente n&#227;o tem efeitos colaterais graves&#44; s&#227;o relatados na literatura efeitos como sonol&#234;ncia&#44; tontura e&#44; at&#233; mesmo&#44; edema perif&#233;rico&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;19&#44;24</span></a></p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Gabapentina &#40;Gamibetal&#174;&#44; Progresse&#174;&#44; Gabaneurin&#174;&#41;</span><p id="par0275" class="elsevierStylePara elsevierViewall">Geralmente usada para epilepsia e dor neurop&#225;tica&#44; &#233; um anticonvulsivante derivado do neurotransmissor GABA&#46; &#201; o estabilizador de humor mais estudado na dermatologia e &#233; especialmente eficaz em situa&#231;&#245;es em que a sensibiliza&#231;&#227;o do sistema nervoso central &#233; um fator mediador&#46; Usa&#8208;se mais amplamente em neuralgia p&#243;s&#8208;herp&#233;tica&#44; mas tamb&#233;m pode ser usada em prurido cr&#244;nico e outras dores de origem neural&#44; como notalgia parest&#233;sica e prurido braquiorradial&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">25&#44;27&#44;28</span></a> Pode ser prescrito na posologia de&#160;300&#160;at&#233;&#160;3600&#160;mg&#47;dia&#46; Essa medica&#231;&#227;o tem bom padr&#227;o de seguran&#231;a no que concerne a intera&#231;&#245;es medicamentosas e tem como efeitos adversos mais relatados a sonol&#234;ncia&#44; enjoo&#44; vis&#227;o dupla&#44; disfasia&#44; entre outros&#46; N&#227;o h&#225; dados suficientes para uso na gesta&#231;&#227;o e lact&#226;ncia&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">15&#44;29</span></a></p></span></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Ansiol&#237;ticos</span><p id="par0280" class="elsevierStylePara elsevierViewall">As drogas ansiol&#237;ticas s&#227;o usadas para al&#237;vio dos sintomas de ansiedade&#44; atuam diretamente no sistema l&#237;mbico&#46; Usados em situa&#231;&#245;es especiais&#44; como s&#237;ndrome do p&#226;nico e estresse p&#243;s&#8208;traum&#225;tico&#44; por exemplo&#44; t&#234;m um alto poder sedativo e risco de depend&#234;ncia&#46; S&#227;o divididos em benzodiazep&#237;nicos e n&#227;o benzodiazep&#237;nicos&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a></p><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Benzodiazep&#237;nicos</span><p id="par0285" class="elsevierStylePara elsevierViewall">Os benzodiazep&#237;nicos atuam farmacologicamente como moduladores do GABA&#46; Deve&#8208;se limitar o uso dessas drogas por de 3&#160;a&#160;4&#160;semanas devido ao alto potencial de depend&#234;ncia e uso abusivo&#46; Alguns autores falam no uso m&#225;ximo de&#160;6&#160;semanas&#46; Al&#233;m disso&#44; &#233; necess&#225;rio ter cuidado quando da retirada da medica&#231;&#227;o&#44; devido &#224; possibilidade de apresenta&#231;&#227;o de sintomas de abstin&#234;ncia&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">16</span></a> Podem ser divididos em curta dura&#231;&#227;o&#58; triazolam &#40;Halcion&#174;&#41;&#44; midazolam &#40;Dormonid&#174;&#41;&#59; curta&#8208;intermedi&#225;ria&#58; alprazolam &#40;Frontal&#174;&#44; Alfron&#174;&#41;&#59; intermedi&#225;ria&#8208;prolongada&#58; bromazepam &#40;Lexotan&#174;&#41;&#44; nitrazepam &#40;Sonebon&#174;&#41;&#44; lorazepam &#40;Lorax&#41;&#59; prolongada&#58; clonazepam &#40;Rivotril&#174;&#41;&#44; diazepam &#40;Valium&#174;&#41;&#44; clobazam &#40;Frisium&#174;&#44; Urbanil&#174;&#41;&#44; flurazepam &#40;Dalmadorm&#174;&#41;&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Podem ser citadas entre os efeitos adversos dessas medica&#231;&#245;es a dificuldade de aprendizado&#44; amn&#233;sia&#44; agressividade&#44; confus&#227;o&#46; H&#225; risco de depress&#227;o respirat&#243;ria em pacientes com doen&#231;as pulmonares cr&#244;nicas&#44; bem como com o uso de drogas depressoras do SNC &#40;&#225;lcool&#41;&#46; S&#227;o contraindicados no primeiro trimestre de gesta&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">15&#44;17</span></a></p></span></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">N&#227;o benzodiazep&#237;nicos</span><span id="sec0215" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Buspirona &#40;Ansitec&#174;&#41;</span><p id="par0300" class="elsevierStylePara elsevierViewall">&#201; um medicamento ansiol&#237;tico n&#227;o benzodiazep&#237;nico que n&#227;o tem potencial de depend&#234;ncia&#46; Seu in&#237;cio de a&#231;&#227;o &#233; um pouco mais lento&#44; leva de&#160;2&#160;a&#160;4&#160;semanas e por isso n&#227;o deve ser usada em situa&#231;&#245;es mais agudas&#46; Devido ao seu perfil&#44; &#233; preferido nos casos em que terapias mais longas precisam ser institu&#237;das&#46; Sugere&#8208;se o in&#237;cio com&#160;15&#160;mg&#47;dia&#44; aumenta&#8208;se&#160;15&#160;mg a cada semana&#44; com uma dose m&#225;xima de&#160;60&#160;mg&#47;dia&#44; divididas em duas doses&#44; por sua meia&#8208;vida curta&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;16</span></a></p></span><span id="sec0220" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Zolpidem &#40;Stilnox&#174;&#41;</span><p id="par0310" class="elsevierStylePara elsevierViewall">Usado como indutor do sono&#44; o zolpidem deve ser usado na dose de&#160;5&#160;a&#160;10&#160;mg antes de dormir&#46; Essa droga atua de forma semelhante aos benzodiazep&#237;nicos&#44; pode levar a confus&#227;o mental e toler&#226;ncia ao longo do tempo de uso e por isso deve ser usado por curtos per&#237;odos&#46;</p></span></span><span id="sec0225" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Rea&#231;&#245;es cut&#226;neas adversas aos psicof&#225;rmacos</span><p id="par0320" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es cut&#226;neas adversas desencadeadas pelo uso de psicof&#225;rmacos s&#227;o estimadas de acordo com cada droga em at&#233;&#160;39&#37; dos casos&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">30&#8208;36</span></a> H&#225; risco aumentado associado ao sexo feminino&#44; aos idosos e aos negros&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">30</span></a> Entre os psicotr&#243;picos&#44; os estabilizadores de humor s&#227;o os que apresentam a maior preval&#234;ncia e a maior gravidade das rea&#231;&#245;es cut&#226;neas&#44; as quais podem ser potencialmente fatais&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">31</span></a></p><p id="par0325" class="elsevierStylePara elsevierViewall">O manejo das rea&#231;&#245;es cut&#226;neas associadas aos psicof&#225;rmacos e a decis&#227;o de suspend&#234;&#8208;los devem levar em conta a gravidade da manifesta&#231;&#227;o cut&#226;nea e a gravidade da doen&#231;a psiqui&#225;trica&#46; Al&#233;m disso&#44; o poss&#237;vel preju&#237;zo em rela&#231;&#227;o &#224; interrup&#231;&#227;o abrupta da medica&#231;&#227;o deve ser considerado e avaliado&#46;</p><span id="sec0120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Prurido</span><p id="par0330" class="elsevierStylePara elsevierViewall">O prurido pode ocorrer pelo uso de qualquer antidepressivo&#44; estabilizador de humor e antipsic&#243;tico&#46; Tamb&#233;m &#233; uma manifesta&#231;&#227;o relatada pelo uso de benzodiazep&#237;nicos&#44; embora seja menos frequente&#46;</p><p id="par0335" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; a bupropiona apresenta a maior incid&#234;ncia de prurido&#44; enquanto as menores taxas s&#227;o encontradas com a fluoxetina&#44; paroxetina&#44; sertralina e venlafaxina&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0345" class="elsevierStylePara elsevierViewall">Antipsicoticos&#58; risperidona&#44; olanzapina&#44; quetiapina e clozapina&#46;</p><p id="par0350" class="elsevierStylePara elsevierViewall">Benzodiazep&#237;nicos&#58; h&#225; uma maior incid&#234;ncia pelo uso de alprazolan&#46;</p></span><span id="sec0125" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Erup&#231;&#245;es exantem&#225;ticas</span><p id="par0360" class="elsevierStylePara elsevierViewall">&#201; a rea&#231;&#227;o cut&#226;nea adversa mais comum desencadeada pelo uso de psicotr&#243;picos&#46; Est&#225; associada ao uso de antidepressivos&#44; estabilizadores de humor&#44; antipsic&#243;tico&#46;</p><p id="par0365" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46; Entre os antidepressivos tric&#237;clicos&#44; a maior incid&#234;ncia ocorre com o uso de clomipramina&#46;</p><p id="par0370" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; gabapentina&#44; l&#237;tio&#44; &#225;cido valproico&#44; lamotrigina&#44; topiramato&#46;</p><p id="par0375" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#44; quetiapina&#44; clozapina&#44; haldol&#44; ziprasidona&#46;</p><p id="par0380" class="elsevierStylePara elsevierViewall">Benzodiazep&#237;nicos&#58; alprazolam tem a maior incid&#234;ncia&#46;</p></span><span id="sec0130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0180">Urtic&#225;ria e angioedema</span><p id="par0390" class="elsevierStylePara elsevierViewall">&#201; uma manifesta&#231;&#227;o adversa comum&#46; Est&#225; associada ao uso de antidepressivos&#44; estabilizadores de humor e antipsic&#243;tico&#46;</p><p id="par0395" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0400" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; lamotrigina&#46;</p><p id="par0405" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#44; clozapina e haldol&#46;</p><p id="par0410" class="elsevierStylePara elsevierViewall">Benzodiazep&#237;nicos&#58; alprazolam&#46;</p></span><span id="sec0135" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0185">Eritema pigmentar fixo</span><p id="par0420" class="elsevierStylePara elsevierViewall">As les&#245;es surgem em at&#233;&#160;8&#160;horas ap&#243;s a ingest&#227;o da medica&#231;&#227;o e costumam ser assintom&#225;ticas&#46;</p><p id="par0425" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0430" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; l&#237;tio&#44; gabapentina&#46;</p><p id="par0435" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#44; quetiapina e haloperidol&#46;</p></span><span id="sec0140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0190">Fotossensibilidade</span><p id="par0445" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es de fotossensibilidade s&#227;o divididas em fotot&#243;xica e fotoal&#233;rgicas e s&#227;o desencadeadas pela exposi&#231;&#227;o &#224; radia&#231;&#227;o ultravioleta com o uso de determinadas medica&#231;&#245;es&#46;</p><p id="par0450" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; paroxetina&#44; sertralina&#44; escitalopram&#46; H&#225; poucos casos relatados com o uso de antidepressivos tric&#237;clicos&#46;</p><p id="par0455" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; lamotrigina&#46;</p><p id="par0460" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; clorpromazina&#44; risperidona&#44; olanzapina&#44; quetiapina&#44; clozapina&#44; haldol&#46;</p></span><span id="sec0145" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0195">Pigmenta&#231;&#227;o cut&#226;nea</span><p id="par0470" class="elsevierStylePara elsevierViewall">A pigmenta&#231;&#227;o cut&#226;nea geralmente ocorre ap&#243;s o uso prolongado de alguns psicotr&#243;picos&#46; Na maioria dos casos&#44; desaparecem lentamente ap&#243;s a interrup&#231;&#227;o do agente&#46; Podem levar meses ou anos para a o desaparecimento completo da pigmenta&#231;&#227;o&#46;</p><p id="par0475" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; antidepressivos tric&#237;clicos apresentam as maiores incid&#234;ncias&#46;</p><p id="par0480" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; gabapentina e lamotrigina&#46;</p><p id="par0485" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; clorpromazina&#44; risperidona&#44; olanzapina&#44; quetiapina&#44; clozapina e haldol&#46;</p></span><span id="sec0150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0200">Alopecia</span><p id="par0495" class="elsevierStylePara elsevierViewall">Geralmente ocorre de forma difusa&#46; A perda de cabelo cessa com a descontinua&#231;&#227;o do uso da medica&#231;&#227;o&#46; Est&#225; associada ao uso de alguns antidepressivos&#44; estabilizadores de humor e antipsic&#243;tico&#46;</p><p id="par0500" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; inibidores seletivos de recapta&#231;&#227;o de serotonina&#46;</p><p id="par0505" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#44; lamotrigina&#44; &#225;cido valproico&#46;</p><p id="par0510" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#46;</p></span><span id="sec0155" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0205">Erup&#231;&#245;es acneiformes</span><p id="par0520" class="elsevierStylePara elsevierViewall">Geralmente as les&#245;es apresentam&#8208;se como p&#250;stulas foliculares&#44; sem comed&#245;es&#46; Ocorrem na face&#44; t&#243;rax e na parte superior do dorso&#46; Est&#227;o associados&#44; principalmente&#44; com o uso dos antidepressivos&#46;</p><p id="par0525" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0530" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#44; lamotrigina&#44; topiramato&#46;</p><p id="par0535" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; quetiapina&#44; risperidona&#46;</p></span><span id="sec0160" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0210">Rea&#231;&#245;es psoriasiformes</span><p id="par0545" class="elsevierStylePara elsevierViewall">As les&#245;es geralmente aparecem bilateralmente nos cotovelos&#44; joelhos e couro cabeludo&#46;</p><p id="par0550" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; escitalopram&#44; venlafaxina&#46;</p><p id="par0555" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#44; &#225;cido valproico&#46;</p><p id="par0560" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona e quetiapina&#46;</p></span><span id="sec0165" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0215">Dermatite seborreica</span><p id="par0570" class="elsevierStylePara elsevierViewall">&#201; uma manifesta&#231;&#227;o comum aos psicof&#225;rmacos&#44; especialmente pelo uso de antidepressivos e estabilizadores de humor&#46;</p><p id="par0575" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; paroxetina&#44; venlafaxina&#46;</p><p id="par0580" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; 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risperidona e clozapina&#46;</p></span><span id="sec0175" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0225">S&#237;ndrome de Stevens&#8208;Johnson e necr&#243;lise epidermica t&#243;xica</span><p id="par0620" class="elsevierStylePara elsevierViewall">S&#227;o rea&#231;&#245;es adversas graves associadas&#44; principalmente&#44; ao uso de estabilizadores de humor&#46; Raramente ocorre pelo uso de antidepressivos&#46; A medica&#231;&#227;o suspeita jamais deve ser prescrita novamente&#46;</p><p id="par0625" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; sertralina&#44; paroxetina&#44; bupropiona e duloxetina&#46;</p><p id="par0630" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; lamotrigina e &#225;cido valproico&#46;</p><p id="par0635" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; quetiapina e clozapina&#46;</p></span><span id="sec0180" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0230">Eritrodermia exfoliativa</span><p id="par0645" class="elsevierStylePara elsevierViewall">&#201; uma rea&#231;&#227;o adversa grave&#46; Est&#225; mais associada com uso de alguns antidepressivos tric&#237;clicos&#46; Raramente ocorre com o uso de antipsic&#243;ticos&#46;</p><p id="par0650" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; amitriptilina&#44; nortriptilina&#44; clomipramina&#44; mirtazapina&#46;</p><p id="par0655" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#46;</p><p id="par0660" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; e quetiapina&#46;</p></span><span id="sec0185" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0235">S&#237;ndrome DRESS</span><p id="par0670" class="elsevierStylePara elsevierViewall">&#201; uma rea&#231;&#227;o adversa grave e que&#44; al&#233;m do envolvimento cut&#226;neo&#44; apresenta febre e acometimento de v&#225;rios &#243;rg&#227;os&#46;</p><p id="par0675" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; amitriptilina&#44; imipramina e fluoxetina&#46;</p><p id="par0680" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; lamotrigina&#44; &#225;cido valproico&#46;</p><p id="par0685" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; olanzapina&#46;</p></span><span id="sec0190" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0240">Vasculite de hipersensibilidade</span><p id="par0695" class="elsevierStylePara elsevierViewall">Inicialmente&#44; manifesta&#8208;se por p&#250;rpura nos membros inferiores&#46; Pode haver acometimento sist&#234;mico de diferentes &#243;rg&#227;os&#46;</p><p id="par0700" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; paroxetina&#44; fluoxetina e sertralina&#46;</p><p id="par0705" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina e lamotrigina&#46;</p><p id="par0710" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; clozapina&#44; Haldol&#46;</p></span></span><span id="sec0195" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0245">Conclus&#227;o</span><p id="par0715" class="elsevierStylePara elsevierViewall">O reconhecimento e o manejo psicofarmacol&#243;gico de transtornos psicocut&#226;neos n&#227;o deve ser negligenciado pelo dermatologista&#44; uma vez que pacientes dermatol&#243;gicos t&#234;m alta preval&#234;ncia de comorbidades psiqui&#225;tricas&#46; A habilidade de prescrever psicotr&#243;picos torna&#8208;se ainda mais relevante quando o tratamento psiqui&#225;trico &#233; preterido pelo paciente&#46; Ademais&#44; a prescri&#231;&#227;o de psicof&#225;rmacos por um dermatologista pode vir a ser mais bem aceita do que a prescrita por um psiquiatra&#44; devido ao estigma que envolve sa&#250;de mental e o tratamento com esse profissional&#46;</p><p id="par0720" class="elsevierStylePara elsevierViewall">O dermatologista deve conhecer os mecanismos&#44; as indica&#231;&#245;es e os efeitos colaterais dos agentes psicotr&#243;picos mais usados para que possa fornecer o melhor tratamento e evitar o agravamento das psicodermatoses&#46; &#201; necess&#225;rio&#44; por&#233;m&#44; que seja estabelecida uma atitude de empatia e suporte a esses pacientes para que a interven&#231;&#227;o com psicotr&#243;picos seja aceita e aderida&#46; A escolha do psicotr&#243;pico deve ser baseada na psicopatologia subjacente&#46; Os transtornos depressivos&#44; de ansiedade&#44; psic&#243;ticos e de del&#237;rio e os obsessivos&#8208;compulsivos s&#227;o os mais encontrados na pr&#225;tica dermatol&#243;gica&#46;</p><p id="par0725" class="elsevierStylePara elsevierViewall">Ressalta&#8208;se&#44; ainda&#44; que o uso de psicof&#225;rmacos constitui um dos componentes do tratamento global ao paciente com psicodermatose&#46; Deve&#8208;se continuar a encorajar a busca de tratamento psiqui&#225;trico e suporte psicoter&#225;pico para que o paciente tenha melhores resultados terap&#234;uticos e melhor qualidade de vida&#46;</p></span><span id="sec0230" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0250">Suporte financeiro</span><p id="par0765" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0200" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0255">Contribui&#231;&#227;o dos autores</span><p id="par0730" class="elsevierStylePara elsevierViewall">Magda Blessmann Weber&#58; Concep&#231;&#227;o e planejamento do estudo&#44; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#44; revis&#227;o cr&#237;tica da literatura&#44; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0735" class="elsevierStylePara elsevierViewall">J&#250;lia Kanaan Recuero&#58; Elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica da literatura&#44; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0740" class="elsevierStylePara elsevierViewall">Camila Saraiva Almeida&#58; Elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica da literatura&#44; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0210" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0260">Conflitos de interesse</span><p id="par0750" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0260" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0265">Quest&#245;es EMC</span><p id="par0770" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></p></span></span>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; M&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluoxetina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prozac&#44; Daforin</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;C&#225;psula 10 e 20&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;80&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o requer monitora&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 20&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Larga experi&#234;ncia em gestantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meia&#8208;vida longa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paroxetina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paxil&#44; Pondera&#44; Aropax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 10&#44; 20 e 30&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;60&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o requer monitora&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sertralina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tolrest&#44; Zoloft&#44; Assert&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 50 e 100&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#8211;200&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Usada em pacientes com problemas hep&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluvoxamine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Luvox&#44; Revoc&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 50 e 100&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#8211;300&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fracionar dose se &#62;&#160;150&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Citalopram&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Celexa&#44; Procimax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 20 e 40&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;60&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recomendada em doen&#231;a hep&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maior risco card&#237;aco em doses &#62;&#160;40&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escitalopram&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lexapro&#44; Reconter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 5&#44; 10 e 20&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#8211;20mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 20&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; M&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nortriptilina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pamelor</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psulas 10&#44; 25&#44; 50 e 75&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;150&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG em mulheres &#62;&#160;40 anos e homens &#62; 30 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 2&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mais seguro em idosos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amitriptilina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amytril&#44; Tryptanol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimidos 10&#44; 25 e 75&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;150&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG em mulheres &#62; 40 anos e homens &#62; 30 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Doxepina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o dispon&#237;vel no Brasil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#8211;300&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Necessidade de manipula&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clomipramina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anafranil</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;Dr&#225;gea 10&#44; 25 e 75&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;250&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG em mulheres &#62; 40 anos e homens &#62; 30 anos</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o injet&#225;vel 25&#160;mg&#47;2&#160;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2296244.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de antidepressivos tric&#237;clicos</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; m&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mirtazapina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remeron&#44; Zispin&#44; Norset</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 15&#44; 30 e 45&#160;mg</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#8211;45&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sedativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ganho de peso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Efeitos anticolin&#233;rgicos &#40;raros&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bupropiona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wellbutrin&#44; Wellbutrin XL Zetron&#44; Zetron XL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 150 e 300&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#8211;300&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Libera&#231;&#227;o lenta ou imediata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venlafaxina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Efexor&#44; Zyvifax&#44; Zaredrop</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;C&#225;psula 37&#44;5&#44; 50&#44; 75 e 150&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#8211;300&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dose fracionada</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 75&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duloxetina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Velija&#44; Cymbalta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;C&#225;psula 30 e 60&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trazodona</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Donaren</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 50 e 100&#160;mg</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#8211;600&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sedativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fracionar dose acima de 300&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Usar em pacientes hospitalizados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2296245.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de outros antidepressivos</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0030"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; m&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pimozida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Orap&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 1 e 4&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#8211;4&#160;mg&#47;dia &#8211;20&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risperidona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risperdal&#44; Riss&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido de 1&#44; 2 e 3&#160;mgSolu&#231;&#227;o 1&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#160;mg&#47;dia &#8211; 8&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Olanzapina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zyprexa&#44; Zopix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 2&#44;5&#44; 5 e 10&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;5&#8211;5&#160;mg&#47;dia &#8211; 15&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Quetiapina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Seroquel&#44; Quetrox&#44; Queropax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 100 e 200&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#8211;750&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aripripazol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aristab&#44; Abilify&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 10&#44; 15&#44; 20 e 30&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;30&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ziprasidona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Geodon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psula 40 e 80&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#8211;160&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Haloperidol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Haldol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 1 e 5&#160;mgSolu&#231;&#227;o oral 2&#160;mg&#47;mLSolu&#231;&#227;o injet&#225;vel 5&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&#8211;15&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2296249.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de antipsic&#243;ticos</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0035"
        "etiqueta" => "Tabela 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at5"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; m&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">L&#237;tio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carbolitium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 300 e 450&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">600&#8211;2400&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Necess&#225;rio Litemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lamotrigina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lamitor&#44; Lamictal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 50 e 100&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#8211;200&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SSJ&#47;NET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carbamazepina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tegretol&#44; Tegrex&#44; Carmazin&#44; Tegretard</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 200 e 400&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&#8211;1600&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SSJ&#47;NET &#40;Alelo HLA&#8208;B1502&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 20&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Valproato de s&#243;dio</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Depakote&#44; Depakene</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 300 e 500&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#8211;60&#160;mg&#47;kg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatotoxicidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xarope 250&#160;mg&#47;5&#160;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pancreatite&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Teratog&#234;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Topiramato</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amato&#44; Sigmax</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 50 e 100&#160;mg</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#8211;200&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Miopia&#44; glaucoma de &#226;ngulo fechado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acidose metab&#243;lica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disfun&#231;&#227;o cognitiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comportamento suicida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pr&#233;&#8208;gabalina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lyrica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psula 75 e 150&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#8211;600&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comportamento suicida&#44; convuls&#227;o com retirada r&#225;pida&#44; angioedema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gabapentina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gabaneurin&#44; Gamibetal&#44; Progresse&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psula 300 e 400&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">900&#8211;3600&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de&#160;estabilizadores do humor e anticonvulsivantes</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46; Assinale a resposta incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Transtornos psicofisiol&#243;gicos englobam dermatoses prim&#225;rias que podem ser agravadas por fatores emocionais ou estresse&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Transtornos psiqui&#225;tricos prim&#225;rios podem levar a manifesta&#231;&#245;es cut&#226;neas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Transtornos psiqui&#225;tricos secund&#225;rios n&#227;o t&#234;m rela&#231;&#227;o com psicodermatoses&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Doen&#231;as sensitivas da pele ou mucosas n&#227;o apresentam les&#245;es dermatol&#243;gicas prim&#225;rias&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46; Assinale a resposta correta&#44; em rela&#231;&#227;o aos antidepressivos&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Os antidepressivos t&#234;m indica&#231;&#245;es espec&#237;ficas para algumas dermatoses&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Pode&#8208;se esperar at&#233; 2 meses para observar os efeitos terap&#234;uticos desejados&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Os antidepressivos tric&#237;clicos s&#227;o os que apresentam maior quantidade de efeitos colaterais&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Pode&#8208;se suspender o tratamento assim que forem alcan&#231;ados os efeitos terap&#234;uticos desejados&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46; Em rela&#231;&#227;o aos ISRC&#44; &#233; correto afirmar que&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; N&#227;o devem ser usados durante a gesta&#231;&#227;o&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Apresentam boa tolerabilidade e um dos principais efeitos colaterais &#233; a redu&#231;&#227;o da libido&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Necess&#225;ria monitora&#231;&#227;o regular dos pacientes&#44; independentemente da faixa et&#225;ria&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; A sertralina n&#227;o deve ser usada em pacientes com doen&#231;a hep&#225;tica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46; Para os antidepressivos tric&#237;clicos assinale a op&#231;&#227;o incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; &#201; a classe de antidepressivos mais antiga&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Os efeitos colaterais mais importantes s&#227;o a boca seca&#44; constipa&#231;&#227;o&#44; tonturas&#44; taquicardia e reten&#231;&#227;o urin&#225;ria&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Dores neurop&#225;ticas e prurido respondem ao tratamento com doses mais baixas do que as geralmente empregadas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Pacientes com doen&#231;as cardiovasculares e doentes com infarto do mioc&#225;rdio recente podem usar a droga sem restri&#231;&#245;es&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46; Assinale a resposta correta em rela&#231;&#227;o aos antipsic&#243;ticos&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; S&#227;o divididos entre t&#237;picos e at&#237;picos&#44; os at&#237;picos s&#227;o mais novos&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Podem ser usados na popula&#231;&#227;o mais idosa sem necessidade de cuidados especiais&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Raramente causam rea&#231;&#245;es adversas cut&#226;neas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; T&#234;m pouco efeito quando usados para o tratamento de del&#237;rio de parasitose e dermatite artefacta&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46; Com rela&#231;&#227;o aos estabilizadores de humor&#44; assinale a resposta incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Incluem os antiepil&#233;ticos e o l&#237;tio&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; S&#227;o bastante eficazes no tratamento da dor neurop&#225;tica e do prurido&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; N&#227;o t&#234;m efeitos teratog&#234;nicos e podem ser usados sem restri&#231;&#227;o durante a gesta&#231;&#227;o&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Podem ser usados tamb&#233;m nas psicodermatoses ligadas &#224; compuls&#227;o&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46; Assinale abaixo a op&#231;&#227;o incorreta em rela&#231;&#227;o aos benzodiazep&#237;nicos&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; S&#227;o drogas que causam depend&#234;ncia e n&#227;o devem ser usadas por tempo longo&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; A retirada r&#225;pida da droga pode causar sintomas de abstin&#234;ncia&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Efeitos colaterais como amn&#233;sia&#44; agressividade e confus&#227;o mental podem ocorrer com o uso dessas drogas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Usados sem restri&#231;&#245;es em doentes com doen&#231;a pulmonar cr&#244;nica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46; Assinale abaixo a op&#231;&#227;o incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Psicof&#225;rmacos&#44; em geral&#44; podem causar rea&#231;&#245;es cut&#226;neas indesejadas em pacientes tratados com essas drogas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; As manifesta&#231;&#245;es comuns s&#227;o prurido&#44; erup&#231;&#245;es exantem&#225;ticas e urtic&#225;ria&#47;angioedema&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Antidepressivos de todas as classes podem apresentar eritema pigmentado fixo&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Rea&#231;&#245;es de fotosenssibilidade s&#227;o raras em todas as drogas usadas para psicodermatoses&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46; Rea&#231;&#245;es psorisiformes e dermatite seborreica s&#227;o mais comuns com&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Antidepressivos e estabilizadores de humor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Benzodiazep&#237;nicos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Antidepressivos tric&#237;clicos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; L&#237;tio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46; SSJ e NET ocorrem com mais frequ&#234;ncia com quais das medica&#231;&#245;es abaixo&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Antidepressivos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Estabilizadores de humor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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Uso de psicofármacos na Dermatologia
Magda Blessmann Weber
Autor para correspondência
mbw@terra.com.br

Autor para correspondência.
, Júlia Kanaan Recuero, Camila Saraiva Almeida
Serviço de Dermatologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A preval&#234;ncia de comorbidades psiqui&#225;tricas &#233; maior e mais frequente em pacientes dermatol&#243;gicos do que na popula&#231;&#227;o em geral&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">1</span></a> Estima&#8208;se que 25&#37; a 30&#37; dos pacientes t&#234;m alguma desordem mental ou problema emocional&#44; que podem ser respons&#225;veis pela causa&#44; pela predisposi&#231;&#227;o ou pelo fator agravante da afec&#231;&#227;o cut&#226;nea&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">1&#44;2</span></a> A psicodermatologia estuda as doen&#231;as cut&#226;neas resultantes da intera&#231;&#227;o pele&#8208;mente&#44; atrav&#233;s da sua uni&#227;o com a psiquiatria&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">3</span></a> Engloba manifesta&#231;&#245;es cut&#226;neas resultantes ou agravadas por fatores psicol&#243;gicos e a avalia&#231;&#227;o dos preju&#237;zos mentais e sociais decorrentes dessas dermatoses&#46; O manejo das psicodermatoses &#233; fundamental no campo da dermatologia&#44; visto que os dermatologistas s&#227;o respons&#225;veis pela maioria dos atendimentos ambulatoriais por problemas psicocut&#226;neos&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">4</span></a> Ademais&#44; muitos desses pacientes recusam interven&#231;&#227;o psiqui&#225;trica seja pelo estigma associado &#224;s doen&#231;as mentais ou pela falta de reconhecimento do componente psicol&#243;gico na sua doen&#231;a cut&#226;nea e&#44; deixam o manejo exclusivamente ao dermatologista&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> Quando h&#225; resist&#234;ncia &#224; busca de tratamento psiqui&#225;trico&#44; o dermatologista deve apoiar seu paciente com uma posi&#231;&#227;o de n&#227;o julgamento&#44; fornecer medica&#231;&#227;o psicotr&#243;pica indicada e encorajar a avalia&#231;&#227;o com um psiquiatra como complemento&#44; e n&#227;o como um substituto para a rela&#231;&#227;o terap&#234;utica&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">O uso associado de psicof&#225;rmacos&#44; representados pelos antidepressivos&#44; antipsic&#243;ticos&#44; ansiol&#237;ticos e estabilizadores de humor&#44; torna&#8208;se essencial nesses doentes&#44; uma vez que as les&#245;es cut&#226;neas podem ser agravadas quando psicopatologias subjacentes n&#227;o s&#227;o tratadas&#46; Dessa forma&#44; o conhecimento e a seguran&#231;a em prescrever os psicotr&#243;picos mais usados auxiliam no manejo dos sintomas psiqui&#225;tricos associados com dermatoses&#44; como tamb&#233;m no manejo de sintomas dermatol&#243;gicos desencadeados por s&#237;ndromes psiqui&#225;tricas&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Situa&#231;&#245;es cl&#237;nicas em que o conhecimento de psicotr&#243;picos se faz necess&#225;rio ao dermatologista&#58;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Manejo de sintomas dermatol&#243;gicos associados a enfermidades psiqui&#225;tricas&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Manejo de sintomas psiqui&#225;tricos associados a condi&#231;&#245;es dermatol&#243;gicas&#44; como fobia social nos pacientes com vitiligo&#59;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Manejo de efeitos adversos associados ao uso de psicotr&#243;picos&#59;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Manejo de outros efeitos farmacol&#243;gicos dessas medica&#231;&#245;es&#44; como&#44; por exemplo&#44; os efeitos anticolin&#233;rgico e anti&#8208;histam&#237;nico dos antidepressivos e antipsic&#243;ticos&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Classifica&#231;&#227;o das psicodermatoses</span><p id="par0040" class="elsevierStylePara elsevierViewall">As psicodermatoses podem ser classificadas em seis categorias&#58;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">1&#46;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Transtornos psicofisiol&#243;gicos&#58; compreendem dermatoses prim&#225;rias que s&#227;o exacerbadas por fatores emocionais e estresse&#46; Exemplo&#58; psor&#237;ase e dermatite at&#243;pica&#59;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">2&#46;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Transtornos psiqui&#225;tricos prim&#225;rios&#58; compreendem doen&#231;as psiqui&#225;tricas prim&#225;rias que apresentam manifesta&#231;&#245;es cut&#226;neas autoinfligidas&#44; como manifesta&#231;&#227;o secund&#225;ria a doen&#231;a psiqui&#225;trica&#46; Exemplo&#58; tricotilomania&#44; del&#237;rio de parasitose&#44; dermatite artefacta e escoria&#231;&#245;es neur&#243;ticas&#59;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">3&#46;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Transtornos psiqui&#225;tricos secund&#225;rios&#58; englobam doen&#231;as psiqui&#225;tricas que surgem como consequ&#234;ncia do impacto psicossocial decorrente de dermatoses existentes&#46; Exemplo&#58; fobia social&#44; depress&#227;o que pode surgir junto com a psor&#237;ase e a alopecia areata&#59;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">4&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Doen&#231;a cut&#226;nea sensitiva&#58; compreende sintomas psicog&#234;nicos&#44; como prurido ou queima&#231;&#227;o sem evid&#234;ncia de afec&#231;&#227;o cut&#226;nea ou outra condi&#231;&#227;o m&#233;dica&#46; Exemplo&#58; vulvodinia e glossodinia&#59;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">5&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Altera&#231;&#245;es pelo uso de drogas psicoativas para tratamento dermatol&#243;gico&#46; Exemplo&#58; prurido&#44; erup&#231;&#245;es exantem&#225;ticas e s&#237;ndrome de Stevens&#8208;Johnson&#59;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">6&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Doen&#231;as multifatoriais&#58; compreendem doen&#231;as nas quais fatores psiconeuroimunol&#243;gicos desencadeiam ou agravam condi&#231;&#245;es cut&#226;neas&#46; Exemplo&#58; dermatite at&#243;pica&#44; psor&#237;ase&#44; alopecia areata&#44; prurido cr&#244;nico&#46;</p></li></ul></p><p id="par0075" class="elsevierStylePara elsevierViewall">A maioria dos pacientes com psicodermatoses encontram&#8208;se classificada nos diagn&#243;sticos psiqui&#225;tricos a seguir&#58;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> Transtornos depressivos&#59; Transtornos de ansiedade&#59; Transtornos psic&#243;ticos e transtornos de del&#237;rio&#59; Transtorno obsessivo&#8208;compulsivo e transtornos de controle de impulso&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Embora os dermatologistas n&#227;o tenham treinamento espec&#237;fico para fazer diagn&#243;sticos psiqui&#225;tricos&#44; uma s&#243;lida rela&#231;&#227;o m&#233;dico&#8208;paciente&#44; desenvolvida ao longo de v&#225;rias consultas&#44; pode auxili&#225;&#8208;los na identifica&#231;&#227;o de doen&#231;as psiqui&#225;tricas subjacentes&#46; A partir de ent&#227;o&#44; devem ser capazes de escolher os psicotr&#243;picos indicados para uma doen&#231;a psiqui&#225;trica espec&#237;fica&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">7&#44;8</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Antidepressivos</span><p id="par0085" class="elsevierStylePara elsevierViewall">O uso dos antidepressivos para tratamento de depress&#227;o baseia&#8208;se na teoria monoamin&#233;rgica da depress&#227;o&#44; na qual defici&#234;ncias de serotonina&#44; noradrenalina e&#47;ou dopamina estariam implicadas na g&#234;nese da doen&#231;a&#46; Dessa forma&#44; as diferentes classes de antidepressivos atuam no aumento desses neurotransmissores&#44; seja pela inibi&#231;&#227;o de suas recapta&#231;&#245;es&#44; seja pela inibi&#231;&#227;o da enzima respons&#225;vel pelas suas degrada&#231;&#245;es &#40;inibidores da monoaminoxidase&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">9</span></a> Al&#233;m disso&#44; s&#227;o aprovados tamb&#233;m para o tratamento de transtornos de ansiedade&#44; fobia social e transtorno obsessivo compulsivo&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Nenhuma das classes dos antidepressivos mostrou ser a mais efetiva entre todas no tratamento da depress&#227;o e nenhum deles &#233; indicado especificamente para cada doen&#231;a psicocut&#226;nea&#46; Alcan&#231;am sua dose terap&#234;utica em 4&#160;a&#160;6&#160;semanas&#44; mas recomenda&#8208;se o in&#237;cio com doses baixas e aumento gradual &#8211; preferencialmente a cada&#160;14&#160;dias&#44; pelo menos&#46; Na aus&#234;ncia de resposta no fim das&#160;6&#160;semanas iniciais&#44; n&#227;o se deve insistir na medica&#231;&#227;o&#44; e sim optar por uma droga alternativa&#46; Se houver uma melhoria parcial dos sintomas&#44; aumentar as doses at&#233; chegar naquela ideal para o paciente&#44; avalia&#8208;se de forma individualizada&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> Efeitos adversos s&#227;o diferentes para cada classe e mais relatados com o uso de antidepressivos tric&#237;clicos&#46; Apesar de n&#227;o causarem depend&#234;ncia&#44; s&#227;o descritos sintomas ap&#243;s a descontinua&#231;&#227;o abrupta&#44; como ins&#244;nia&#44; n&#225;useas&#44; sudorese&#44; dist&#250;rbios sensoriais&#46; Para a retirada&#44; &#233; indicada a diminui&#231;&#227;o gradativa da droga por v&#225;rias semanas&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a> Considera&#8208;se permanecer com a droga por pelo menos seis meses ap&#243;s resposta terap&#234;utica&#44; antes de tentar retir&#225;&#8208;la&#44; o que minimiza os riscos de retorno dos sintomas&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;12</span></a></p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Inibidores seletivos de recapta&#231;&#227;o de serotonina</span><p id="par0095" class="elsevierStylePara elsevierViewall">Os inibidores seletivos de recapta&#231;&#227;o de serotonina &#40;ISRS&#41;&#44; listados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 1</a>&#44; inibem de forma seletiva a recapta&#231;&#227;o da serotonina&#44; aumentam&#44; assim&#44; a disponibilidade desse neurotransmissor&#44; que &#233; respons&#225;vel por influenciar o humor&#44; a cogni&#231;&#227;o&#44; o sono&#44; o apetite e o comportamento sexual&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">13</span></a> O aumento da disponibilidade da serotonina na fenda sin&#225;ptica modularia a melhoria dos sintomas da depress&#227;o baseada na teoria monoamin&#233;rgica da depress&#227;o&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Apresentam um bom perfil de seguran&#231;a e costumam apresentar maior tolerabilidade em rela&#231;&#227;o aos tric&#237;clicos&#44; s&#227;o a primeira escolha terap&#234;utica para muitos pacientes&#46; Os efeitos adversos mais relatados s&#227;o as altera&#231;&#245;es gastrointestinais &#8211; n&#225;usea e dispepsia &#8211; ins&#244;nia&#44; altera&#231;&#227;o de peso e disfun&#231;&#227;o sexual&#44; como anorgasmia e redu&#231;&#227;o de libido&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a> &#201; liberado seu uso para gestantes&#44; com prefer&#234;ncia para aqueles de meia&#8208;vida mais curta&#44; como sertralina e paroxetina&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antidepressivos tric&#237;clicos</span><p id="par0105" class="elsevierStylePara elsevierViewall">Essa classe &#233; a mais antiga dos antidepressivos&#44; f&#225;rmacos listados na <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 2</a>&#46; Atuam de forma semelhante aos ISRS&#44; aumentam a serotonina e norepinefrina na fenda sin&#225;ptica&#46; Foram substitu&#237;dos pelos ISRS ao longo dos anos&#44; pois t&#234;m mais efeito sedativo e maior quantidade de outros efeitos colaterais&#46; Entretanto&#44; esses f&#225;rmacos&#44; em especial a doxepina&#44; apresentam propriedades mais semelhantes aos anti&#8208;histam&#237;nicos e por isso s&#227;o muito usados para ins&#244;nia e prurido&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">15&#44;16</span></a> Tamb&#233;m t&#234;m boa atua&#231;&#227;o em pacientes com dores de origem neural&#46; Geralmente&#44; as doses necess&#225;rias para tratamento da dor e do prurido costumam ser menores do que as doses antidepressivas&#46; A nortriptilina tem menos efeitos adversos e deve ser escolhida para uso em idosos&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Est&#227;o descritos entre os efeitos adversos boca seca&#44; constipa&#231;&#227;o&#44; tonturas&#44; vis&#227;o turva&#44; taquicardia e reten&#231;&#227;o urin&#225;ria&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">17</span></a> Devem ser usados de forma cautelosa em pacientes portadores de doen&#231;as card&#237;acas&#44; tais como altera&#231;&#245;es de condu&#231;&#227;o&#46; H&#225; contraindica&#231;&#227;o absoluta para o uso em pacientes ap&#243;s epis&#243;dio recente &#40;at&#233;&#160;6&#160;semanas&#41; de infarto agudo do mioc&#225;rdio&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a> Podem ser usados na gesta&#231;&#227;o&#44; evita&#8208;se a prescri&#231;&#227;o no primeiro trimestre<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">18</span></a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Doxepina &#40;Sinequan&#174;&#41;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Este antidepressivo tric&#237;clico tem propriedades anti&#8208;histam&#237;nicas potentes e &#233; usado na dermatologia para pacientes com prurido cr&#244;nico e urtic&#225;ria&#44; &#233; uma op&#231;&#227;o ao uso de difenidramina e hidroxizine&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;17</span></a> Al&#233;m disso&#44; quando em formula&#231;&#227;o t&#243;pica &#40;creme&#160;5&#37;&#41;&#44; n&#227;o provoca as rea&#231;&#245;es colaterais caracter&#237;sticas dos antidepressivos tric&#237;clicos usados via oral&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">16&#44;19</span></a> As dosagens&#44; quando usados oralmente&#44; devem ser iniciadas com&#160;25&#160;mg&#47;dia e podem ser aumentadas a cada semana em&#160;10&#160;a&#160;25&#160;mg&#44; alcan&#231;am o m&#225;ximo de&#160;100&#160;mg&#47;dia&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A seda&#231;&#227;o &#233; o principal efeito adverso e pode ser necess&#225;rio ajuste nos hor&#225;rios das doses em caso de queixa do paciente&#46; Pacientes com hist&#243;ria de altera&#231;&#245;es do ritmo card&#237;aco devem ser submetidos a eletrocardiograma antes do in&#237;cio do tratamento&#46; Em casos de aumento das doses da medica&#231;&#227;o&#44; sugere&#8208;se que o exame seja repetido quando a dosagem chegar a&#160;100&#160;mg&#47;dia<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">12</span></a>&#46; Atualmente&#44; no Brasil&#44; esse medicamento encontra&#8208;se somente em farm&#225;cias de manipula&#231;&#227;o&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Outros antidepressivos</span><p id="par0125" class="elsevierStylePara elsevierViewall">Esses f&#225;rmacos antidepressivos est&#227;o citados na <a class="elsevierStyleCrossRef" href="#tbl0025">tabela 3</a>&#58;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0235" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Mirtazapina &#40;Remeron&#174;&#44; Zispin&#174;&#44; Norset&#174;&#41;</span><p id="par0135" class="elsevierStylePara elsevierViewall">Antidepressivo tetrac&#237;clico que age diretamente no aumento da quantidade de serotonina e noradrenalina&#46; Devido ao seu alto potencial de seda&#231;&#227;o e aumento de peso&#44; &#233; preferencialmente usado em pacientes terminais&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0240" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Bupropiona &#40;Wellbutrin&#174;&#44; Zetron&#174;&#41;</span><p id="par0145" class="elsevierStylePara elsevierViewall">F&#225;rmaco de recapta&#231;&#227;o seletiva de norepinefrina e dopamina&#46; Como tem menos efeitos adversos sexuais e semelhante capacidade antidepressiva&#44; ele &#233; preferido em pacientes com queixa de altera&#231;&#245;es da libido&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">12</span></a> Tamb&#233;m deve ser considerado seu uso em pacientes com dist&#250;rbios do sono&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a> &#201; necess&#225;rio o fracionamento da dose&#44; exceto nos casos de uso de comprimidos de libera&#231;&#227;o lenta&#46; &#201; uma medica&#231;&#227;o geralmente bem tolerada e tem como principais efeitos colaterais ins&#244;nia&#44; agita&#231;&#227;o&#44; dor de cabe&#231;a&#44; constipa&#231;&#227;o&#44; boca seca&#44; n&#225;useas e tremores&#46; Convuls&#245;es s&#227;o efeitos raros&#44; mas que podem ocorrer e&#44; devido a isso&#44; deve&#8208;se estar atento ao indicar uso em pacientes com hist&#243;ria de epilepsia&#46; Deve&#8208;se tamb&#233;m evitar o uso da bupropiona em pacientes com hist&#243;ria de abuso de &#225;lcool e drogas&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;16</span></a> N&#227;o &#233; recomendado uso da bupropiona na gesta&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0245" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Venlafaxina &#40;Efexor&#174;&#44; Zyvifax&#174;&#41;</span><p id="par0155" class="elsevierStylePara elsevierViewall">Medica&#231;&#227;o liberada oficialmente para uso em depress&#227;o e ansiedade&#44; a venlafaxina parece atuar na recepta&#231;&#227;o de serotonina e noradrenalina&#46; Recomenda&#8208;se o in&#237;cio da medica&#231;&#227;o com doses de&#160;75&#160;mg&#47;dia&#44; com aumento a cada duas semanas&#44; chega&#8208;se a uma dose m&#225;xima de&#160;300&#160;mg&#47;dia que deve ser dividida em duas tomadas&#46; Os efeitos adversos mais comumente relatados desse f&#225;rmaco s&#227;o ins&#244;nia e ansiedade e a press&#227;o arterial deve ser monitorada quando usada em doses altas&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">14&#44;15</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">A respeito do uso na gesta&#231;&#227;o&#44; apesar de n&#227;o ter estudos em gestantes&#44; experimentos com animais n&#227;o demonstraram teratogenicidade&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">18</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Antipsic&#243;ticos</span><p id="par0165" class="elsevierStylePara elsevierViewall">Os antipsic&#243;ticos&#44; relacionados na <a class="elsevierStyleCrossRef" href="#tbl0030">tabela 4</a>&#44; s&#227;o antagonistas dos receptores de dopamina&#44; atuam principalmente no bloqueio dos receptores do subtipo D2&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">20</span></a> S&#227;o divididos em antipsic&#243;ticos t&#237;picos &#8211; pimozida&#44; clorpromazina e haloperidol &#8211; e antipsic&#243;ticos at&#237;picos &#8211; risperidona&#44; olanzapina&#44; sulpiride e quetiapina&#46; Os at&#237;picos t&#234;m menor afinidade pelos receptores D2&#44; portanto t&#234;m menor incid&#234;ncia de efeitos extrapiramidais&#44; como distonia e parkinsonismo&#44; do que os antipsic&#243;ticos t&#237;picos&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0170" class="elsevierStylePara elsevierViewall">As principais vias dopamin&#233;rgicas no sistema nervoso central s&#227;o&#58; mesocorticol&#237;mbica&#44; nigroestriatal e t&#250;bero&#8208;infundibular&#46; Disfun&#231;&#245;es na via mesocorticol&#237;mbica est&#227;o associadas &#224; psicose&#44; esquizofrenia e transtorno do d&#233;ficit de aten&#231;&#227;o&#59; disfun&#231;&#245;es na via nigroestriatal est&#227;o relacionadas com a doen&#231;a de Parkinson e tamb&#233;m com efeitos colaterais motores quando usada como terapia dopamin&#233;rgica&#44; inclusive efeitos extrapiramidais&#46; J&#225; as disfun&#231;&#245;es na via t&#250;bero&#8208;infundibular provocam altera&#231;&#245;es na secre&#231;&#227;o de prolactina&#44; podem ocasionar galactorreia e amenorreia &#8211; uma vez que a dopamina &#233; respons&#225;vel por inibir a secre&#231;&#227;o de prolactina&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">13</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Os antipsic&#243;ticos podem provocar efeitos colaterais decorrentes da liga&#231;&#227;o a outros receptores&#44; como ganho de peso &#40;receptores histam&#237;nicos&#41;&#44; hipotens&#227;o ortost&#225;tica &#40;&#945;&#8208;adren&#233;rgicos&#41;&#44; constipa&#231;&#227;o e xerostomia &#40;receptores muscar&#237;nicos&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">20</span></a> Tamb&#233;m podem aumentar o risco de infarto mioc&#225;rdico e eventos isqu&#234;micos transit&#243;rios em pacientes idosos&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Na dermatologia&#44; os antipsic&#243;ticos podem ser usados principalmente nos transtornos delirantes&#44; t&#234;m como principal exemplo o del&#237;rio de parasitose e a dermatite artefacta&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">17</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">O haloperidol &#233; o f&#225;rmaco mais bem estudado em rela&#231;&#227;o ao uso na gesta&#231;&#227;o&#44; &#233; o antipsic&#243;tico de uso preferencial nessas pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">21</span></a></p><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pimozida &#40;Orap&#174;&#41;</span><p id="par0190" class="elsevierStylePara elsevierViewall">Esse f&#225;rmaco &#233; o antipsic&#243;tico de primeira gera&#231;&#227;o mais usado em psicodermatologia&#46; Age como antagonista potente do receptor central de dopamina&#46; &#201; indicado iniciar com&#160;1&#160;mg&#47;dia&#44; com aumento progressivo a cada duas semanas&#44; at&#233; chegar &#224; dose&#8208;alvo&#44; estabelecida entre&#160;2&#160;e&#160;6&#160;mg&#47;dia&#46; A dosagem deve ser mantida por pelo menos um m&#234;s ap&#243;s o alcance da melhoria dos sintomas&#46; Mesmo que raros&#44; devido &#224; baixa dose usada para doen&#231;as cut&#226;neas&#44; h&#225; efeitos adversos citados na literatura que incluem acatisia&#44; rigidez muscular e sensa&#231;&#227;o de inquieta&#231;&#227;o&#46; Devido &#224; possibilidade de altera&#231;&#227;o de intervalo QT&#44; &#233; recomendado eletrocardiograma em pacientes com hist&#243;ria de doen&#231;a card&#237;aca antes do in&#237;cio do tratamento&#46; Nos pacientes jovens&#47;h&#237;gidos&#44; ainda &#233; controversa a necessidade do exame eletrocardiogr&#225;fico&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">16</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Risperidona &#40;Risperdal&#174;&#44; Riss&#174;&#41;</span><p id="par0195" class="elsevierStylePara elsevierViewall">Principal medica&#231;&#227;o usada para del&#237;rio de parasitoses&#44; a risperidona &#233; um antipsic&#243;tico de nova gera&#231;&#227;o e deve ser iniciada numa dose de&#160;0&#44;5&#160;mg antes de dormir&#44; deve ser aumentada em semanas at&#233; chegar a uma dose m&#225;xima de&#160;4&#160;mg&#47;dia&#46; Pode ocasionar hiperprolactinemia e&#44; consequentemente&#44; galactorreia&#44; amenorreia e disfun&#231;&#245;es sexuais&#46; Demais efeitos adversos&#44; como a seda&#231;&#227;o&#44; s&#227;o poucos comuns e geralmente se resolvem nos primeiros dias&#46; Essa medica&#231;&#227;o tamb&#233;m deve ser usada com cautela em pacientes com hist&#243;ria de anormalidades no eletrocardiograma&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;22</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Olanzapina &#40;Zyprexa&#174;&#44; Zopix&#174;&#41;</span><p id="par0200" class="elsevierStylePara elsevierViewall">A olanzapina &#233; recomendada em doses baixas para doen&#231;as psicocut&#226;neas&#46; Sugere&#8208;se iniciar com uma dose de&#160;5&#8208;10&#160;mg&#47;dia at&#233; chegar numa dose alvo de&#160;15&#160;mg&#47;dia&#46; Apesar de ser uma medica&#231;&#227;o geralmente bem tolerada&#44; tem como principal efeito adverso o ganho de peso e consequentemente s&#237;ndrome metab&#243;lica e aumento do risco cardiovascular&#46; Em fun&#231;&#227;o disso&#44; &#233; necess&#225;rio controle do peso&#44; monitoramento de press&#227;o arterial&#44; glicose e lipidograma durante o tratamento com essa medica&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;14&#44;17</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Quetiapina &#40;Seroquel&#174;&#44; Quetrox&#174;&#44; Queropax&#174;&#41;</span><p id="par0205" class="elsevierStylePara elsevierViewall">A quetiapina &#233; bem indicada nos casos de pacientes resistentes aos tratamentos anteriores e nos pacientes idosos&#46; No tratamento de psicoses n&#227;o dermatol&#243;gicas&#44; &#233; prescrita inicialmente com&#160;25&#160;mg duas vezes ao dia e aumentada at&#233;&#160;750&#160;mg&#47;dia&#46; No entanto&#44; para uso dermatol&#243;gico &#233; recomendada redu&#231;&#227;o da dose de in&#237;cio e de manuten&#231;&#227;o&#46; A dosagem de&#160;150&#160;mg fracionada em duas tomadas &#233; indicada para o tratamento de del&#237;rio de parasitose&#44; por exemplo&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;23</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">Aumento de peso&#44; sonol&#234;ncia e hipotens&#227;o ortost&#225;tica est&#227;o entre os efeitos colaterais mais relatados&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;14</span></a></p></span><span id="sec0250" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Aripiprazol &#40;Aristab&#174;&#44; Abilify&#174;&#41;</span><p id="par0220" class="elsevierStylePara elsevierViewall">&#201; um antipsic&#243;tico de nova gera&#231;&#227;o&#44; &#233; diferenciado pela baixa rela&#231;&#227;o com dist&#250;rbios metab&#243;licos e efeitos colin&#233;rgicos&#46; Tem sido usado para pacientes com del&#237;rio de parasitose e escoria&#231;&#245;es neur&#243;ticas&#44; com bons resultados com doses entre&#160;2&#8211;30&#160;mg&#47;dia&#46; Geralmente n&#227;o causa altera&#231;&#245;es no peso&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a></p></span><span id="sec0255" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ziprasidona &#40;Geodon&#174;&#41;</span><p id="par0230" class="elsevierStylePara elsevierViewall">Tamb&#233;m &#233; um antipsic&#243;tico de nova gera&#231;&#227;o&#44; como o aripiprazol&#46; Diferencia&#8208;se dos demais por n&#227;o ter efeitos anticolin&#233;rgicos e por baixa propens&#227;o a s&#237;ndrome metab&#243;lica&#44; al&#233;m de baixa incid&#234;ncia de efeitos sedativos&#46; Entretanto&#44; tem mais riscos de altera&#231;&#227;o no intervalo QT do que os outros antipsic&#243;ticos at&#237;picos&#46; &#201; usado com sucesso no tratamento de pacientes com del&#237;rio de parasitoses com doses que variam entre&#160;20&#8211;80&#160;mg&#47;duas vezes ao dia&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Estabilizadores do humor</span><p id="par0235" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#44; como as drogas antiepil&#233;ticas e o l&#237;tio&#44; s&#227;o aprovados para uso em transtorno bipolar e em epilepsia&#46; Seus mecanismos n&#227;o est&#227;o completamente elucidados&#44; mas acredita&#8208;se que tenham a&#231;&#227;o no sistema nervoso central com o poder de controle da excita&#231;&#227;o neuronal&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a></p><p id="par0240" class="elsevierStylePara elsevierViewall">Muitas dessas medica&#231;&#245;es&#44; conforme citadas na <a class="elsevierStyleCrossRef" href="#tbl0035">tabela 5</a>&#44; s&#227;o usadas em dor neurop&#225;tica cut&#226;nea e s&#227;o tamb&#233;m eficazes no manejo do prurido cr&#244;nico&#44; al&#233;m de outros dist&#250;rbios sensoriais cut&#226;neos&#44; como as dermatoses autoinduzidas&#46; Principalmente devido ao seu poder de controle de compuls&#227;o&#44; s&#227;o inclu&#237;das no tratamento das dermatoses relacionadas &#224; autoescoria&#231;&#227;o&#44; como prurigo nodular e l&#237;quen simples cr&#244;nico&#44; e as les&#245;es autoinflingidas&#44; como tricotilomania e dermatite artefacta&#46; Essas medica&#231;&#245;es s&#227;o sabidamente teratog&#234;nicas e devem ser evitadas&#44; se poss&#237;vel&#44; em pacientes do sexo feminino em idade f&#233;rtil&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a></p><elsevierMultimedia ident="tbl0035"></elsevierMultimedia><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">L&#237;tio &#40;Carbolitium&#174;&#41;</span><p id="par0245" class="elsevierStylePara elsevierViewall">O carbonato de l&#237;tio&#44; usado no tratamento do transtorno bipolar e depress&#227;o grave&#44; age na altera&#231;&#227;o do metabolismo das catecolaminas neuronais&#46; Deve&#8208;se manter acompanhamento com dosagem do l&#237;tio s&#233;rico inicialmente a cada&#160;60&#8208;90&#160;dias&#44; pode&#8208;se estender esse intervalo at&#233;&#160;6&#160;meses&#44; conforme o tempo de uso&#46; As amostras de sangue devem ser colhidas&#160;8&#160;a&#160;12&#160;horas ap&#243;s a ingest&#227;o da dose anterior e antes da dose seguinte&#46; Recomenda&#8208;se a manuten&#231;&#227;o da litemia entre 0&#44;5&#8208;1&#44;0&#160;mEq&#47;L&#44; o equivalente a dose de&#160;600&#8211;900&#160;mg&#47;dia&#46; Sinais de toxicidade podem come&#231;ar a aparecer j&#225; com&#160;1&#44;0&#8211;1&#44;5&#160;mEq&#47;L&#46; Requer tamb&#233;m monitoramento frequente de fun&#231;&#245;es renais e tireoidiana&#46; Devemos estar atentos quanto ao uso do l&#237;tio&#44; devido ao seu alto &#237;ndice de efeitos adversos cut&#226;neos&#44; como a pioria ou o gatilho para in&#237;cio de psor&#237;ase e acne&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;24&#44;25</span></a> O l&#237;tio &#233; indicado no controle do comportamento impulsivo de pacientes com tricotilomania&#44; devido &#224; alta associa&#231;&#227;o com transtorno obsessivo compulsivo&#44; as doses variam entre&#160;900&#8211;1&#46;500&#160;mg&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">12&#44;26</span></a> Pacientes com <span class="elsevierStyleItalic">skin</span><span class="elsevierStyleItalic">picking</span> tamb&#233;m podem beneficiar&#8208;se do uso do l&#237;tio para o controle do impulso&#44; embora n&#227;o haja uma dose especificada na literatura&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Lamotrigina &#40;Lamitor&#174;&#44; Lamictal&#174;&#41;</span><p id="par0250" class="elsevierStylePara elsevierViewall">&#201; uma medica&#231;&#227;o usada para tratamento de crises convulsivas&#46; Age farmacologicamente nos canais de s&#243;dio neuronais&#44; estabiliza as membranas e inibe a libera&#231;&#227;o de glutamato&#44; principalmente&#46; Foi demonstrado benef&#237;cio no uso para <span class="elsevierStyleItalic">skin</span> picking&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a>&#46; As doses citadas na literatura variam entre&#160;12&#44;5&#8211;300&#160;mg&#47;dia&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Carbamazepina &#40;Tegretol&#174;&#44; Tegrezin&#174;&#44; Tegretard&#174;&#44; Tegrex&#174;&#44; Carmazin&#174;&#41;</span><p id="par0255" class="elsevierStylePara elsevierViewall">A carbamazepina&#44; mesmo que n&#227;o se tenha completamente compreendida sua a&#231;&#227;o&#44; sabe&#8208;se que estabiliza a membrana nervosa hiperexcitada&#46; &#201; indicada para o tratamento de epilepsia&#44; transtorno bipolar&#44; depress&#227;o e dor de origem neural&#46; Na dermatologia&#44; podemos destacar o uso dessa medica&#231;&#227;o em neuralgia p&#243;s&#8208;herp&#233;tica&#46; Recomenda&#8208;se&#44; al&#233;m do fracionamento&#44; iniciar com doses mais baixas com aumento progressivo&#46; A dose recomendada para dor neurop&#225;tica &#233; de&#160;600&#8211;1200&#160;mg&#47;dia&#46; Efeitos adversos como sintomas gastrointestinais&#44; tonturas e vis&#227;o turva est&#227;o relatados&#44; como tamb&#233;m efeitos cut&#226;neos&#44; relatados a seguir no texto&#46; Riscos mais raros&#44; como agranulocitose e anemia apl&#225;sica&#44; est&#227;o relatados na literatura&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a></p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Valproato de s&#243;dio &#40;Depakote&#174;&#44; Depakene&#174;&#44; Zyvalprex&#174;&#41;</span><p id="par0260" class="elsevierStylePara elsevierViewall">A atividade do valproato de s&#243;dio&#44; que se converte em &#225;cido valproico no organismo&#44; parece ter rela&#231;&#227;o com o aumento do GABA no sistema nervoso central&#46; As doses indicadas para epilepsia iniciam&#8208;se com&#160;10&#160;a&#160;15&#160;mg&#47;kg&#47;dia&#44; podem ser aumentadas em&#160;5&#160;a&#160;10&#160;mg&#47;kg&#47;dia semanalmente&#46; Considera&#8208;se que doses abaixo de&#160;60&#160;mg&#47;kg&#47;dia t&#234;m boa resposta cl&#237;nica&#46; Para dor neurop&#225;tica as refer&#234;ncias sugerem doses entre&#160;250&#160;e&#160;1500&#160;mg&#47;dia com dose fracionada&#46; Al&#233;m dos usos na dor cr&#244;nica&#44; existem relatos de tratamentos com valproato de s&#243;dio em pacientes com nevos epid&#233;rmicos verrucosos inflamat&#243;rios &#40;NEVIL&#41;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a>&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Topiramato &#40;Amato&#174;&#44; Sigmax&#174;&#41;</span><p id="par0265" class="elsevierStylePara elsevierViewall">Medica&#231;&#227;o anticonvulsivante com m&#250;ltiplos mecanismos de redu&#231;&#227;o de hiperexcitabilidade neuronal usada no tratamento da epilepsia e profilaxia de enxaqueca&#46; Recomenda&#8208;se iniciar com&#160;25&#8211;50&#160;mg por dia por pelo menos uma semana e aumentar a dose a cada uma ou duas semanas&#46; Tem uma dose di&#225;ria entre&#160;200 e&#160;400&#160;mg&#47;dia e tem como dose m&#225;xima&#160;1600&#160;mg&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;24</span></a> Existem relatos do uso do topiramato em tratamento de tricotilomania&#44; s&#227;o necess&#225;rios estudos com popula&#231;&#245;es maiores para confirma&#231;&#227;o de efic&#225;cia&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">26</span></a></p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Pr&#233;&#8208;gabalina &#40;Lyrica&#174;&#41;</span><p id="par0270" class="elsevierStylePara elsevierViewall">Essa medica&#231;&#227;o tem nos canais de c&#225;lcio neuronais o seu mecanismo de a&#231;&#227;o&#46; Tem em sua bula indica&#231;&#227;o formal para dor neurop&#225;tica&#44; epilepsia e fibromialgia&#46; A pr&#233;&#8208;gabalina tem boa a&#231;&#227;o no controle da dor neurop&#225;tica e bom perfil de seguran&#231;a por interagir com poucos f&#225;rmacos em compara&#231;&#227;o com as outras medica&#231;&#245;es dessa classe&#46; Alguns autores indicam seu uso tamb&#233;m para prurido ur&#234;mico&#46; Indica&#8208;se uma dose de&#160;300&#8211;600&#160;mg&#47;dia&#46; Geralmente n&#227;o tem efeitos colaterais graves&#44; s&#227;o relatados na literatura efeitos como sonol&#234;ncia&#44; tontura e&#44; at&#233; mesmo&#44; edema perif&#233;rico&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;19&#44;24</span></a></p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Gabapentina &#40;Gamibetal&#174;&#44; Progresse&#174;&#44; Gabaneurin&#174;&#41;</span><p id="par0275" class="elsevierStylePara elsevierViewall">Geralmente usada para epilepsia e dor neurop&#225;tica&#44; &#233; um anticonvulsivante derivado do neurotransmissor GABA&#46; &#201; o estabilizador de humor mais estudado na dermatologia e &#233; especialmente eficaz em situa&#231;&#245;es em que a sensibiliza&#231;&#227;o do sistema nervoso central &#233; um fator mediador&#46; Usa&#8208;se mais amplamente em neuralgia p&#243;s&#8208;herp&#233;tica&#44; mas tamb&#233;m pode ser usada em prurido cr&#244;nico e outras dores de origem neural&#44; como notalgia parest&#233;sica e prurido braquiorradial&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">25&#44;27&#44;28</span></a> Pode ser prescrito na posologia de&#160;300&#160;at&#233;&#160;3600&#160;mg&#47;dia&#46; Essa medica&#231;&#227;o tem bom padr&#227;o de seguran&#231;a no que concerne a intera&#231;&#245;es medicamentosas e tem como efeitos adversos mais relatados a sonol&#234;ncia&#44; enjoo&#44; vis&#227;o dupla&#44; disfasia&#44; entre outros&#46; N&#227;o h&#225; dados suficientes para uso na gesta&#231;&#227;o e lact&#226;ncia&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">15&#44;29</span></a></p></span></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Ansiol&#237;ticos</span><p id="par0280" class="elsevierStylePara elsevierViewall">As drogas ansiol&#237;ticas s&#227;o usadas para al&#237;vio dos sintomas de ansiedade&#44; atuam diretamente no sistema l&#237;mbico&#46; Usados em situa&#231;&#245;es especiais&#44; como s&#237;ndrome do p&#226;nico e estresse p&#243;s&#8208;traum&#225;tico&#44; por exemplo&#44; t&#234;m um alto poder sedativo e risco de depend&#234;ncia&#46; S&#227;o divididos em benzodiazep&#237;nicos e n&#227;o benzodiazep&#237;nicos&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a></p><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Benzodiazep&#237;nicos</span><p id="par0285" class="elsevierStylePara elsevierViewall">Os benzodiazep&#237;nicos atuam farmacologicamente como moduladores do GABA&#46; Deve&#8208;se limitar o uso dessas drogas por de 3&#160;a&#160;4&#160;semanas devido ao alto potencial de depend&#234;ncia e uso abusivo&#46; Alguns autores falam no uso m&#225;ximo de&#160;6&#160;semanas&#46; Al&#233;m disso&#44; &#233; necess&#225;rio ter cuidado quando da retirada da medica&#231;&#227;o&#44; devido &#224; possibilidade de apresenta&#231;&#227;o de sintomas de abstin&#234;ncia&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">16</span></a> Podem ser divididos em curta dura&#231;&#227;o&#58; triazolam &#40;Halcion&#174;&#41;&#44; midazolam &#40;Dormonid&#174;&#41;&#59; curta&#8208;intermedi&#225;ria&#58; alprazolam &#40;Frontal&#174;&#44; Alfron&#174;&#41;&#59; intermedi&#225;ria&#8208;prolongada&#58; bromazepam &#40;Lexotan&#174;&#41;&#44; nitrazepam &#40;Sonebon&#174;&#41;&#44; lorazepam &#40;Lorax&#41;&#59; prolongada&#58; clonazepam &#40;Rivotril&#174;&#41;&#44; diazepam &#40;Valium&#174;&#41;&#44; clobazam &#40;Frisium&#174;&#44; Urbanil&#174;&#41;&#44; flurazepam &#40;Dalmadorm&#174;&#41;&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Podem ser citadas entre os efeitos adversos dessas medica&#231;&#245;es a dificuldade de aprendizado&#44; amn&#233;sia&#44; agressividade&#44; confus&#227;o&#46; H&#225; risco de depress&#227;o respirat&#243;ria em pacientes com doen&#231;as pulmonares cr&#244;nicas&#44; bem como com o uso de drogas depressoras do SNC &#40;&#225;lcool&#41;&#46; S&#227;o contraindicados no primeiro trimestre de gesta&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">15&#44;17</span></a></p></span></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">N&#227;o benzodiazep&#237;nicos</span><span id="sec0215" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Buspirona &#40;Ansitec&#174;&#41;</span><p id="par0300" class="elsevierStylePara elsevierViewall">&#201; um medicamento ansiol&#237;tico n&#227;o benzodiazep&#237;nico que n&#227;o tem potencial de depend&#234;ncia&#46; Seu in&#237;cio de a&#231;&#227;o &#233; um pouco mais lento&#44; leva de&#160;2&#160;a&#160;4&#160;semanas e por isso n&#227;o deve ser usada em situa&#231;&#245;es mais agudas&#46; Devido ao seu perfil&#44; &#233; preferido nos casos em que terapias mais longas precisam ser institu&#237;das&#46; Sugere&#8208;se o in&#237;cio com&#160;15&#160;mg&#47;dia&#44; aumenta&#8208;se&#160;15&#160;mg a cada semana&#44; com uma dose m&#225;xima de&#160;60&#160;mg&#47;dia&#44; divididas em duas doses&#44; por sua meia&#8208;vida curta&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">11&#44;16</span></a></p></span><span id="sec0220" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Zolpidem &#40;Stilnox&#174;&#41;</span><p id="par0310" class="elsevierStylePara elsevierViewall">Usado como indutor do sono&#44; o zolpidem deve ser usado na dose de&#160;5&#160;a&#160;10&#160;mg antes de dormir&#46; Essa droga atua de forma semelhante aos benzodiazep&#237;nicos&#44; pode levar a confus&#227;o mental e toler&#226;ncia ao longo do tempo de uso e por isso deve ser usado por curtos per&#237;odos&#46;</p></span></span><span id="sec0225" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Rea&#231;&#245;es cut&#226;neas adversas aos psicof&#225;rmacos</span><p id="par0320" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es cut&#226;neas adversas desencadeadas pelo uso de psicof&#225;rmacos s&#227;o estimadas de acordo com cada droga em at&#233;&#160;39&#37; dos casos&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">30&#8208;36</span></a> H&#225; risco aumentado associado ao sexo feminino&#44; aos idosos e aos negros&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">30</span></a> Entre os psicotr&#243;picos&#44; os estabilizadores de humor s&#227;o os que apresentam a maior preval&#234;ncia e a maior gravidade das rea&#231;&#245;es cut&#226;neas&#44; as quais podem ser potencialmente fatais&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">31</span></a></p><p id="par0325" class="elsevierStylePara elsevierViewall">O manejo das rea&#231;&#245;es cut&#226;neas associadas aos psicof&#225;rmacos e a decis&#227;o de suspend&#234;&#8208;los devem levar em conta a gravidade da manifesta&#231;&#227;o cut&#226;nea e a gravidade da doen&#231;a psiqui&#225;trica&#46; Al&#233;m disso&#44; o poss&#237;vel preju&#237;zo em rela&#231;&#227;o &#224; interrup&#231;&#227;o abrupta da medica&#231;&#227;o deve ser considerado e avaliado&#46;</p><span id="sec0120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Prurido</span><p id="par0330" class="elsevierStylePara elsevierViewall">O prurido pode ocorrer pelo uso de qualquer antidepressivo&#44; estabilizador de humor e antipsic&#243;tico&#46; Tamb&#233;m &#233; uma manifesta&#231;&#227;o relatada pelo uso de benzodiazep&#237;nicos&#44; embora seja menos frequente&#46;</p><p id="par0335" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; a bupropiona apresenta a maior incid&#234;ncia de prurido&#44; enquanto as menores taxas s&#227;o encontradas com a fluoxetina&#44; paroxetina&#44; sertralina e venlafaxina&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0345" class="elsevierStylePara elsevierViewall">Antipsicoticos&#58; risperidona&#44; olanzapina&#44; quetiapina e clozapina&#46;</p><p id="par0350" class="elsevierStylePara elsevierViewall">Benzodiazep&#237;nicos&#58; h&#225; uma maior incid&#234;ncia pelo uso de alprazolan&#46;</p></span><span id="sec0125" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Erup&#231;&#245;es exantem&#225;ticas</span><p id="par0360" class="elsevierStylePara elsevierViewall">&#201; a rea&#231;&#227;o cut&#226;nea adversa mais comum desencadeada pelo uso de psicotr&#243;picos&#46; Est&#225; associada ao uso de antidepressivos&#44; estabilizadores de humor&#44; antipsic&#243;tico&#46;</p><p id="par0365" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46; Entre os antidepressivos tric&#237;clicos&#44; a maior incid&#234;ncia ocorre com o uso de clomipramina&#46;</p><p id="par0370" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; gabapentina&#44; l&#237;tio&#44; &#225;cido valproico&#44; lamotrigina&#44; topiramato&#46;</p><p id="par0375" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#44; quetiapina&#44; clozapina&#44; haldol&#44; ziprasidona&#46;</p><p id="par0380" class="elsevierStylePara elsevierViewall">Benzodiazep&#237;nicos&#58; alprazolam tem a maior incid&#234;ncia&#46;</p></span><span id="sec0130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0180">Urtic&#225;ria e angioedema</span><p id="par0390" class="elsevierStylePara elsevierViewall">&#201; uma manifesta&#231;&#227;o adversa comum&#46; Est&#225; associada ao uso de antidepressivos&#44; estabilizadores de humor e antipsic&#243;tico&#46;</p><p id="par0395" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0400" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; lamotrigina&#46;</p><p id="par0405" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#44; clozapina e haldol&#46;</p><p id="par0410" class="elsevierStylePara elsevierViewall">Benzodiazep&#237;nicos&#58; alprazolam&#46;</p></span><span id="sec0135" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0185">Eritema pigmentar fixo</span><p id="par0420" class="elsevierStylePara elsevierViewall">As les&#245;es surgem em at&#233;&#160;8&#160;horas ap&#243;s a ingest&#227;o da medica&#231;&#227;o e costumam ser assintom&#225;ticas&#46;</p><p id="par0425" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0430" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; l&#237;tio&#44; gabapentina&#46;</p><p id="par0435" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#44; quetiapina e haloperidol&#46;</p></span><span id="sec0140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0190">Fotossensibilidade</span><p id="par0445" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es de fotossensibilidade s&#227;o divididas em fotot&#243;xica e fotoal&#233;rgicas e s&#227;o desencadeadas pela exposi&#231;&#227;o &#224; radia&#231;&#227;o ultravioleta com o uso de determinadas medica&#231;&#245;es&#46;</p><p id="par0450" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; paroxetina&#44; sertralina&#44; escitalopram&#46; H&#225; poucos casos relatados com o uso de antidepressivos tric&#237;clicos&#46;</p><p id="par0455" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; 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gabapentina e lamotrigina&#46;</p><p id="par0485" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; clorpromazina&#44; risperidona&#44; olanzapina&#44; quetiapina&#44; clozapina e haldol&#46;</p></span><span id="sec0150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0200">Alopecia</span><p id="par0495" class="elsevierStylePara elsevierViewall">Geralmente ocorre de forma difusa&#46; A perda de cabelo cessa com a descontinua&#231;&#227;o do uso da medica&#231;&#227;o&#46; Est&#225; associada ao uso de alguns antidepressivos&#44; estabilizadores de humor e antipsic&#243;tico&#46;</p><p id="par0500" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; inibidores seletivos de recapta&#231;&#227;o de serotonina&#46;</p><p id="par0505" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#44; lamotrigina&#44; &#225;cido valproico&#46;</p><p id="par0510" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; olanzapina&#46;</p></span><span id="sec0155" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0205">Erup&#231;&#245;es acneiformes</span><p id="par0520" class="elsevierStylePara elsevierViewall">Geralmente as les&#245;es apresentam&#8208;se como p&#250;stulas foliculares&#44; sem comed&#245;es&#46; Ocorrem na face&#44; t&#243;rax e na parte superior do dorso&#46; Est&#227;o associados&#44; principalmente&#44; com o uso dos antidepressivos&#46;</p><p id="par0525" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; em todos os f&#225;rmacos dessa classe&#46;</p><p id="par0530" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#44; lamotrigina&#44; topiramato&#46;</p><p id="par0535" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; quetiapina&#44; risperidona&#46;</p></span><span id="sec0160" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0210">Rea&#231;&#245;es psoriasiformes</span><p id="par0545" class="elsevierStylePara elsevierViewall">As les&#245;es geralmente aparecem bilateralmente nos cotovelos&#44; joelhos e couro cabeludo&#46;</p><p id="par0550" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; escitalopram&#44; venlafaxina&#46;</p><p id="par0555" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#44; &#225;cido valproico&#46;</p><p id="par0560" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona e quetiapina&#46;</p></span><span id="sec0165" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0215">Dermatite seborreica</span><p id="par0570" class="elsevierStylePara elsevierViewall">&#201; uma manifesta&#231;&#227;o comum aos psicof&#225;rmacos&#44; especialmente pelo uso de antidepressivos e estabilizadores de humor&#46;</p><p id="par0575" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; paroxetina&#44; venlafaxina&#46;</p><p id="par0580" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; 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risperidona e clozapina&#46;</p></span><span id="sec0175" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0225">S&#237;ndrome de Stevens&#8208;Johnson e necr&#243;lise epidermica t&#243;xica</span><p id="par0620" class="elsevierStylePara elsevierViewall">S&#227;o rea&#231;&#245;es adversas graves associadas&#44; principalmente&#44; ao uso de estabilizadores de humor&#46; Raramente ocorre pelo uso de antidepressivos&#46; A medica&#231;&#227;o suspeita jamais deve ser prescrita novamente&#46;</p><p id="par0625" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; fluoxetina&#44; sertralina&#44; paroxetina&#44; bupropiona e duloxetina&#46;</p><p id="par0630" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; lamotrigina e &#225;cido valproico&#46;</p><p id="par0635" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; quetiapina e clozapina&#46;</p></span><span id="sec0180" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0230">Eritrodermia exfoliativa</span><p id="par0645" class="elsevierStylePara elsevierViewall">&#201; uma rea&#231;&#227;o adversa grave&#46; Est&#225; mais associada com uso de alguns antidepressivos tric&#237;clicos&#46; Raramente ocorre com o uso de antipsic&#243;ticos&#46;</p><p id="par0650" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; amitriptilina&#44; nortriptilina&#44; clomipramina&#44; mirtazapina&#46;</p><p id="par0655" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; l&#237;tio&#44; carbamazepina&#46;</p><p id="par0660" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; risperidona&#44; e quetiapina&#46;</p></span><span id="sec0185" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0235">S&#237;ndrome DRESS</span><p id="par0670" class="elsevierStylePara elsevierViewall">&#201; uma rea&#231;&#227;o adversa grave e que&#44; al&#233;m do envolvimento cut&#226;neo&#44; apresenta febre e acometimento de v&#225;rios &#243;rg&#227;os&#46;</p><p id="par0675" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; amitriptilina&#44; imipramina e fluoxetina&#46;</p><p id="par0680" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina&#44; lamotrigina&#44; &#225;cido valproico&#46;</p><p id="par0685" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; olanzapina&#46;</p></span><span id="sec0190" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0240">Vasculite de hipersensibilidade</span><p id="par0695" class="elsevierStylePara elsevierViewall">Inicialmente&#44; manifesta&#8208;se por p&#250;rpura nos membros inferiores&#46; Pode haver acometimento sist&#234;mico de diferentes &#243;rg&#227;os&#46;</p><p id="par0700" class="elsevierStylePara elsevierViewall">Antidepressivos&#58; paroxetina&#44; fluoxetina e sertralina&#46;</p><p id="par0705" class="elsevierStylePara elsevierViewall">Estabilizadores de humor&#58; carbamazepina e lamotrigina&#46;</p><p id="par0710" class="elsevierStylePara elsevierViewall">Antipsic&#243;ticos&#58; clozapina&#44; Haldol&#46;</p></span></span><span id="sec0195" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0245">Conclus&#227;o</span><p id="par0715" class="elsevierStylePara elsevierViewall">O reconhecimento e o manejo psicofarmacol&#243;gico de transtornos psicocut&#226;neos n&#227;o deve ser negligenciado pelo dermatologista&#44; uma vez que pacientes dermatol&#243;gicos t&#234;m alta preval&#234;ncia de comorbidades psiqui&#225;tricas&#46; A habilidade de prescrever psicotr&#243;picos torna&#8208;se ainda mais relevante quando o tratamento psiqui&#225;trico &#233; preterido pelo paciente&#46; Ademais&#44; a prescri&#231;&#227;o de psicof&#225;rmacos por um dermatologista pode vir a ser mais bem aceita do que a prescrita por um psiquiatra&#44; devido ao estigma que envolve sa&#250;de mental e o tratamento com esse profissional&#46;</p><p id="par0720" class="elsevierStylePara elsevierViewall">O dermatologista deve conhecer os mecanismos&#44; as indica&#231;&#245;es e os efeitos colaterais dos agentes psicotr&#243;picos mais usados para que possa fornecer o melhor tratamento e evitar o agravamento das psicodermatoses&#46; &#201; necess&#225;rio&#44; por&#233;m&#44; que seja estabelecida uma atitude de empatia e suporte a esses pacientes para que a interven&#231;&#227;o com psicotr&#243;picos seja aceita e aderida&#46; A escolha do psicotr&#243;pico deve ser baseada na psicopatologia subjacente&#46; Os transtornos depressivos&#44; de ansiedade&#44; psic&#243;ticos e de del&#237;rio e os obsessivos&#8208;compulsivos s&#227;o os mais encontrados na pr&#225;tica dermatol&#243;gica&#46;</p><p id="par0725" class="elsevierStylePara elsevierViewall">Ressalta&#8208;se&#44; ainda&#44; que o uso de psicof&#225;rmacos constitui um dos componentes do tratamento global ao paciente com psicodermatose&#46; Deve&#8208;se continuar a encorajar a busca de tratamento psiqui&#225;trico e suporte psicoter&#225;pico para que o paciente tenha melhores resultados terap&#234;uticos e melhor qualidade de vida&#46;</p></span><span id="sec0230" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0250">Suporte financeiro</span><p id="par0765" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0200" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0255">Contribui&#231;&#227;o dos autores</span><p id="par0730" class="elsevierStylePara elsevierViewall">Magda Blessmann Weber&#58; Concep&#231;&#227;o e planejamento do estudo&#44; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#44; revis&#227;o cr&#237;tica da literatura&#44; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0735" class="elsevierStylePara elsevierViewall">J&#250;lia Kanaan Recuero&#58; Elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica da literatura&#44; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0740" class="elsevierStylePara elsevierViewall">Camila Saraiva Almeida&#58; Elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica da literatura&#44; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0210" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0260">Conflitos de interesse</span><p id="par0750" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0260" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0265">Quest&#245;es EMC</span><p id="par0770" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></p></span></span>"
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      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pacientes com doen&#231;as psicocut&#226;neas frequentemente recusam&#44; nas primeiras consultas&#44; interven&#231;&#227;o psiqui&#225;trica&#44; deixam o manejo inicial para o dermatologista&#46; O uso de psicof&#225;rmacos na pr&#225;tica dermatol&#243;gica&#44; representados pelos antidepressivos&#44; antipsic&#243;ticos&#44; ansiol&#237;ticos e estabilizadores de humor&#44; deve ser indicado para que o paciente receba o tratamento mais adequado rapidamente&#46; &#201; importante para o dermatologista ter conhecimento das medica&#231;&#245;es mais comumente usadas para o melhor manejo dos sintomas psiqui&#225;tricos associados a dermatoses&#44; como tamb&#233;m no manejo de sintomas dermatol&#243;gicos desencadeados por enfermidades psiqui&#225;tricas&#46;</p></span>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Weber MB&#44; Recuero JK&#44; Almeida CS&#46; Use of psychiatric drugs in Dermatology&#46; An Bras Dermatol&#46; 2020&#59;95&#58;133&#8211;143&#46;</p>"
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      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Trabalho realizado no Departamento de Dermatologia&#44; Universidade Federal de Ci&#234;ncias da Sa&#250;de de Porto Alegre&#44; Porto Alegre&#44; RS&#44; Brasil&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; M&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluoxetina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prozac&#44; Daforin</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;C&#225;psula 10 e 20&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;80&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o requer monitora&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 20&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Larga experi&#234;ncia em gestantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meia&#8208;vida longa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paroxetina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paxil&#44; Pondera&#44; Aropax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 10&#44; 20 e 30&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;60&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o requer monitora&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sertralina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tolrest&#44; Zoloft&#44; Assert&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 50 e 100&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#8211;200&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Usada em pacientes com problemas hep&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluvoxamine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Luvox&#44; Revoc&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 50 e 100&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#8211;300&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fracionar dose se &#62;&#160;150&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Citalopram&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Celexa&#44; Procimax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 20 e 40&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;60&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recomendada em doen&#231;a hep&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maior risco card&#237;aco em doses &#62;&#160;40&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escitalopram&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lexapro&#44; Reconter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 5&#44; 10 e 20&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#8211;20mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 20&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; M&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nortriptilina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pamelor</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psulas 10&#44; 25&#44; 50 e 75&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;150&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG em mulheres &#62;&#160;40 anos e homens &#62; 30 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 2&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mais seguro em idosos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amitriptilina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amytril&#44; Tryptanol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimidos 10&#44; 25 e 75&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;150&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG em mulheres &#62; 40 anos e homens &#62; 30 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Doxepina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o dispon&#237;vel no Brasil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#8211;300&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Necessidade de manipula&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clomipramina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anafranil</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;Dr&#225;gea 10&#44; 25 e 75&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;250&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ECG em mulheres &#62; 40 anos e homens &#62; 30 anos</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o injet&#225;vel 25&#160;mg&#47;2&#160;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2296244.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de antidepressivos tric&#237;clicos</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; m&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mirtazapina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remeron&#44; Zispin&#44; Norset</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 15&#44; 30 e 45&#160;mg</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#8211;45&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sedativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ganho de peso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Efeitos anticolin&#233;rgicos &#40;raros&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bupropiona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wellbutrin&#44; Wellbutrin XL Zetron&#44; Zetron XL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 150 e 300&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#8211;300&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Libera&#231;&#227;o lenta ou imediata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venlafaxina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Efexor&#44; Zyvifax&#44; Zaredrop</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;C&#225;psula 37&#44;5&#44; 50&#44; 75 e 150&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#8211;300&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dose fracionada</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 75&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duloxetina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Velija&#44; Cymbalta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido&#47;C&#225;psula 30 e 60&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trazodona</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Donaren</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 50 e 100&#160;mg</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#8211;600&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sedativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fracionar dose acima de 300&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Usar em pacientes hospitalizados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2296245.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de outros antidepressivos</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0030"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; m&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pimozida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Orap&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 1 e 4&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#8211;4&#160;mg&#47;dia &#8211;20&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risperidona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risperdal&#44; Riss&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido de 1&#44; 2 e 3&#160;mgSolu&#231;&#227;o 1&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#160;mg&#47;dia &#8211; 8&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Olanzapina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zyprexa&#44; Zopix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 2&#44;5&#44; 5 e 10&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;5&#8211;5&#160;mg&#47;dia &#8211; 15&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Quetiapina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Seroquel&#44; Quetrox&#44; Queropax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 100 e 200&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#8211;750&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aripripazol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aristab&#44; Abilify&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 10&#44; 15&#44; 20 e 30&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#8211;30&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ziprasidona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Geodon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psula 40 e 80&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#8211;160&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Haloperidol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Haldol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 1 e 5&#160;mgSolu&#231;&#227;o oral 2&#160;mg&#47;mLSolu&#231;&#227;o injet&#225;vel 5&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&#8211;15&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2296249.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de antipsic&#243;ticos</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0035"
        "etiqueta" => "Tabela 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at5"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nome comercial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Apresenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose inicial &#8211; m&#225;xima&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observa&#231;&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">L&#237;tio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carbolitium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 300 e 450&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">600&#8211;2400&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Necess&#225;rio Litemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lamotrigina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lamitor&#44; Lamictal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 50 e 100&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#8211;200&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SSJ&#47;NET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carbamazepina</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tegretol&#44; Tegrex&#44; Carmazin&#44; Tegretard</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 200 e 400&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&#8211;1600&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SSJ&#47;NET &#40;Alelo HLA&#8208;B1502&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solu&#231;&#227;o oral 20&#160;mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Valproato de s&#243;dio</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Depakote&#44; Depakene</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 300 e 500&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#8211;60&#160;mg&#47;kg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatotoxicidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xarope 250&#160;mg&#47;5&#160;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pancreatite&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Teratog&#234;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Topiramato</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amato&#44; Sigmax</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comprimido 25&#44; 50 e 100&#160;mg</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#8211;200&#160;mg&#47;dia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Miopia&#44; glaucoma de &#226;ngulo fechado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acidose metab&#243;lica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disfun&#231;&#227;o cognitiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comportamento suicida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pr&#233;&#8208;gabalina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lyrica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psula 75 e 150&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#8211;600&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comportamento suicida&#44; convuls&#227;o com retirada r&#225;pida&#44; angioedema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gabapentina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gabaneurin&#44; Gamibetal&#44; Progresse&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#225;psula 300 e 400&#160;mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">900&#8211;3600&#160;mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Principais tipos de&#160;estabilizadores do humor e anticonvulsivantes</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46; Assinale a resposta incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Transtornos psicofisiol&#243;gicos englobam dermatoses prim&#225;rias que podem ser agravadas por fatores emocionais ou estresse&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Transtornos psiqui&#225;tricos prim&#225;rios podem levar a manifesta&#231;&#245;es cut&#226;neas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Transtornos psiqui&#225;tricos secund&#225;rios n&#227;o t&#234;m rela&#231;&#227;o com psicodermatoses&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Doen&#231;as sensitivas da pele ou mucosas n&#227;o apresentam les&#245;es dermatol&#243;gicas prim&#225;rias&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46; Assinale a resposta correta&#44; em rela&#231;&#227;o aos antidepressivos&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Os antidepressivos t&#234;m indica&#231;&#245;es espec&#237;ficas para algumas dermatoses&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Pode&#8208;se esperar at&#233; 2 meses para observar os efeitos terap&#234;uticos desejados&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Os antidepressivos tric&#237;clicos s&#227;o os que apresentam maior quantidade de efeitos colaterais&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Pode&#8208;se suspender o tratamento assim que forem alcan&#231;ados os efeitos terap&#234;uticos desejados&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46; Em rela&#231;&#227;o aos ISRC&#44; &#233; correto afirmar que&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; N&#227;o devem ser usados durante a gesta&#231;&#227;o&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Apresentam boa tolerabilidade e um dos principais efeitos colaterais &#233; a redu&#231;&#227;o da libido&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Necess&#225;ria monitora&#231;&#227;o regular dos pacientes&#44; independentemente da faixa et&#225;ria&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; A sertralina n&#227;o deve ser usada em pacientes com doen&#231;a hep&#225;tica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46; Para os antidepressivos tric&#237;clicos assinale a op&#231;&#227;o incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; &#201; a classe de antidepressivos mais antiga&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Os efeitos colaterais mais importantes s&#227;o a boca seca&#44; constipa&#231;&#227;o&#44; tonturas&#44; taquicardia e reten&#231;&#227;o urin&#225;ria&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Dores neurop&#225;ticas e prurido respondem ao tratamento com doses mais baixas do que as geralmente empregadas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Pacientes com doen&#231;as cardiovasculares e doentes com infarto do mioc&#225;rdio recente podem usar a droga sem restri&#231;&#245;es&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46; Assinale a resposta correta em rela&#231;&#227;o aos antipsic&#243;ticos&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; S&#227;o divididos entre t&#237;picos e at&#237;picos&#44; os at&#237;picos s&#227;o mais novos&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Podem ser usados na popula&#231;&#227;o mais idosa sem necessidade de cuidados especiais&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Raramente causam rea&#231;&#245;es adversas cut&#226;neas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; T&#234;m pouco efeito quando usados para o tratamento de del&#237;rio de parasitose e dermatite artefacta&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46; Com rela&#231;&#227;o aos estabilizadores de humor&#44; assinale a resposta incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Incluem os antiepil&#233;ticos e o l&#237;tio&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; S&#227;o bastante eficazes no tratamento da dor neurop&#225;tica e do prurido&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; N&#227;o t&#234;m efeitos teratog&#234;nicos e podem ser usados sem restri&#231;&#227;o durante a gesta&#231;&#227;o&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Podem ser usados tamb&#233;m nas psicodermatoses ligadas &#224; compuls&#227;o&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46; Assinale abaixo a op&#231;&#227;o incorreta em rela&#231;&#227;o aos benzodiazep&#237;nicos&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; S&#227;o drogas que causam depend&#234;ncia e n&#227;o devem ser usadas por tempo longo&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; A retirada r&#225;pida da droga pode causar sintomas de abstin&#234;ncia&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Efeitos colaterais como amn&#233;sia&#44; agressividade e confus&#227;o mental podem ocorrer com o uso dessas drogas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Usados sem restri&#231;&#245;es em doentes com doen&#231;a pulmonar cr&#244;nica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46; Assinale abaixo a op&#231;&#227;o incorreta&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Psicof&#225;rmacos&#44; em geral&#44; podem causar rea&#231;&#245;es cut&#226;neas indesejadas em pacientes tratados com essas drogas&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; As manifesta&#231;&#245;es comuns s&#227;o prurido&#44; erup&#231;&#245;es exantem&#225;ticas e urtic&#225;ria&#47;angioedema&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Antidepressivos de todas as classes podem apresentar eritema pigmentado fixo&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; Rea&#231;&#245;es de fotosenssibilidade s&#227;o raras em todas as drogas usadas para psicodermatoses&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46; Rea&#231;&#245;es psorisiformes e dermatite seborreica s&#227;o mais comuns com&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">a&#41; Antidepressivos e estabilizadores de humor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">b&#41; Benzodiazep&#237;nicos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">c&#41; Antidepressivos tric&#237;clicos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d&#41; L&#237;tio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">10&#46; SSJ e NET ocorrem com mais frequ&#234;ncia com quais das medica&#231;&#245;es abaixo&#58;&nbsp;\t\t\t\t\t\t\n
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ISSN: 26662752
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