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8-Hydroxy-2’-deoxyguanosine protein immunoexpression is associated with the pathogenesis of actinic cheilitis - Replay
Cíntia Barreto de Oliveira Varela, Cristianne Kalinne Santos Medeiros
, Jabes Gennedyr da Cruz Lima, Éricka Janine Dantas da Silveira, Patrícia Teixeira de Oliveira
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Postgraduate Program in Dental Sciences, Department of Dentistry, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
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2045
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Comments on: “8-Hydroxy-2’-deoxyguanosine protein immunoexpression is associated with the pathogenesis of actinic cheilitis”" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "793" "paginaFinal" => "794" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ivanka Miranda de Castro Martins, Anna Carolina Miola, Luiz Eduardo Fabrício de Melo Garbers, Hélio Amante Miot" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ivanka Miranda de Castro" "apellidos" => "Martins" ] 1 => array:2 [ "nombre" => "Anna Carolina" "apellidos" => "Miola" ] 2 => array:2 [ "nombre" => "Luiz Eduardo Fabrício de Melo" "apellidos" => "Garbers" ] 3 => array:2 [ "nombre" => "Hélio Amante" "apellidos" => "Miot" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S266627522400136X" "doi" => "10.1016/j.abdp.2024.05.027" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S266627522400136X?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962400117X?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000005/v2_202409130645/S036505962400117X/v2_202409130645/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Correspondence</span>" "titulo" => "8-Hydroxy-2’-deoxyguanosine protein immunoexpression is associated with the pathogenesis of actinic cheilitis - Replay" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor,</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "794" "paginaFinal" => "795" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cíntia Barreto de Oliveira Varela, Cristianne Kalinne Santos Medeiros, Jabes Gennedyr da Cruz Lima, Éricka Janine Dantas da Silveira, Patrícia Teixeira de Oliveira" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Cíntia Barreto de Oliveira" "apellidos" => "Varela" ] 1 => array:4 [ "nombre" => "Cristianne Kalinne Santos" "apellidos" => "Medeiros" "email" => array:1 [ 0 => "cristiannekalinne@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "Jabes Gennedyr da Cruz" "apellidos" => "Lima" ] 3 => array:2 [ "nombre" => "Éricka Janine Dantas" "apellidos" => "da Silveira" ] 4 => array:2 [ "nombre" => "Patrícia Teixeira de" "apellidos" => "Oliveira" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Postgraduate Program in Dental Sciences, Department of Dentistry, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The authors appreciate the comments on their article: “8-Hydroxy-2’-deoxyguanosine protein immunoexpression is associated with the pathogenesis of actinic cheilitis” and would like to clarify some comments regarding the article.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">When this study was carried out, the objective was to verify whether there was an association between 8-Hydroxy-2’-deoxyguanosine protein immunoexpression (8-OHdG) and the degree of morphological severity of actinic cheilitis (AC), since chronic exposure to ultraviolet radiation (UVR) is associated with the development and progression of AC to lip carcinoma. This fact led to the hypothesis that samples with higher degrees of dysplasia could harbor a higher expression of this protein. For this reason, cases of photoexposed healthy lips and photoprotected mucosa were not included in the sample. The inclusion of these two groups is suggested for further studies with comparison purposes with AC cases.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In relation to the sample patients who were smokers, it was not possible to observe a higher expression of 8-OHdG in the analyzed cases and this result may be due to the low percentage of smokers in the sample (7%).</p><p id="par0020" class="elsevierStylePara elsevierViewall">According to the data from the present study, one cannot say that 8-OHdG can be used as a biological marker for the progression of AC to lip carcinoma. However, chronic exposure to UVR leads to the generation of reactive oxygen species (ROS) and, consequently, to the formation of 8-OHdG, which can cause mutations in cell DNA.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In this context, 8-OHdG has been used as a marker of carcinogenesis in several experiments, being well-established as a prognostic factor in esophageal cancer.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">3</span></a> It has also been observed that this protein is overexpressed in actinic keratosis and Bowen's disease lesions when compared to adjacent unaffected tissues, healthy controls and squamous cell carcinoma (SCC) samples.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The expression of the 8-OHdG protein can be observed both in the nucleus and in the cytoplasm since the main source of ROS generation is the mitochondria. This process leads to the oxidation of biomolecules, with consequent homeostatic cell imbalance, resulting in the development of several diseases such as atherosclerosis, diabetes, neurodegenerative disorders and cancer.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">3–5</span></a> Although the present study did not perform a differential analysis between nuclear and cytoplasmic levels of 8-OHdG, one can say, based on the literature, that increased levels of this protein may be related to the pathogenesis of AC.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Cíntia Barreto de Oliveira Varela: Data collection, analysis and interpretation; Critical literature review; Preparation and writing of the manuscript, approved the final version of the manuscript.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Cristianne Kalinne Santos Medeiros: Data collection, analysis and interpretation; Statistical analysis, approved the final version of the manuscript.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Jabes Gennedyr da Cruz Lima: Data collection, analysis and interpretation, approved the final version of the manuscript.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Éricka Janine Dantas da Silveira: Study conception and planning; Effective participation in research orientation, approved the final version of the manuscript.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Patrícia Teixeira de Oliveira: Study conception and planning; Effective participation in research orientation, approved the final version of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-04-05" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Department of Dentistry, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0001" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "8-Hydroxy-2’-deoxyguanosine protein immunoexpression is associated with the pathogenesis of actinic cheilitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.B.O. 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