Letter - Therapy
Darier’s disease: treatment with topical sodium diclofenac 3% gel
Marcella Oliveira Menezes Quitete de Campos
, Giovanna Abrantes Pimenta de Figueiredo, Allyson Capobiango Evangelista, Alexander Richard Bauk
Autor para correspondência
Department of Dermatology, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Lido
4338
Vezesque se leu este artigo
1434
Total PDF
2904
Total HTML
Compartilhar estatÃsticas
array:23 [ "pii" => "S0365059623001460" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.01.019" "estado" => "S300" "fechaPublicacion" => "2023-11-01" "aid" => "799" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:18 [ "pii" => "S2666275223001789" "issn" => "26662752" "doi" => "10.1016/j.abdp.2023.06.014" "estado" => "S300" "fechaPublicacion" => "2023-11-01" "aid" => "799" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cartas ‐ Terapia</span>" "titulo" => "Doença de Darier: terapêutica tópica com diclofenaco de sódio" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "882" "paginaFinal" => "884" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1848 "Ancho" => 3016 "Tamanyo" => 436631 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Região dorsal, quatro meses após início do tratamento. (B) Detalhe do dorso, região escapular direita após tratamento</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marcella Oliveira Menezes Quitete de Campos, Giovanna Abrantes Pimenta de Figueiredo, Allyson Capobiango Evangelista, Alexander Richard Bauk" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Marcella Oliveira Menezes Quitete de" "apellidos" => "Campos" ] 1 => array:2 [ "nombre" => "Giovanna Abrantes Pimenta de" "apellidos" => "Figueiredo" ] 2 => array:2 [ "nombre" => "Allyson Capobiango" "apellidos" => "Evangelista" ] 3 => array:2 [ "nombre" => "Alexander Richard" "apellidos" => "Bauk" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059623001460" "doi" => "10.1016/j.abd.2022.01.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001460?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223001789?idApp=UINPBA00008Z" "url" => "/26662752/0000009800000006/v1_202310100916/S2666275223001789/v1_202310100916/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059623001502" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.04.016" "estado" => "S300" "fechaPublicacion" => "2023-11-01" "aid" => "803" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Therapy</span>" "titulo" => "Pityriasis rubra pilaris induced by topical use of imiquimod 5%" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "884" "paginaFinal" => "886" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1258 "Ancho" => 1675 "Tamanyo" => 165723 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0085" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Clinical image of palmar keratoderma</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lucia Armillas-Lliteras, Maribel Iglesias-Sancho, Arcadi Altemir, Juan Antonio Moreno Romero" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Lucia" "apellidos" => "Armillas-Lliteras" ] 1 => array:2 [ "nombre" => "Maribel" "apellidos" => "Iglesias-Sancho" ] 2 => array:2 [ "nombre" => "Arcadi" "apellidos" => "Altemir" ] 3 => array:2 [ "nombre" => "Juan Antonio" "apellidos" => "Moreno Romero" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223001844" "doi" => "10.1016/j.abdp.2023.06.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223001844?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001502?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000006/v2_202310301240/S0365059623001502/v2_202310301240/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0365059623001587" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.12.005" "estado" => "S300" "fechaPublicacion" => "2023-11-01" "aid" => "813" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Tropical/Infectious and parasitic dermatology</span>" "titulo" => "Nontuberculous mycobacteriosis (<span class="elsevierStyleItalic">Mycobacterium chelonae</span>): fatal outcome in a patient with severe systemic lupus erythematosus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "878" "paginaFinal" => "881" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1109 "Ancho" => 1675 "Tamanyo" => 265409 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0130" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Detail of the erythematous-violaceous ulcerated nodules, with hematic necrotic crusts</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bárbara Elias do Carmo Barbosa, Priscila Neri Lacerda, Luana Moraes Campos, Mariângela Esther Alencar Marques, Silvio Alencar Marques, Luciana Patrícia Fernandes Abbade" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Bárbara Elias do Carmo" "apellidos" => "Barbosa" ] 1 => array:2 [ "nombre" => "Priscila Neri" "apellidos" => "Lacerda" ] 2 => array:2 [ "nombre" => "Luana Moraes" "apellidos" => "Campos" ] 3 => array:2 [ "nombre" => "Mariângela Esther Alencar" "apellidos" => "Marques" ] 4 => array:2 [ "nombre" => "Silvio Alencar" "apellidos" => "Marques" ] 5 => array:2 [ "nombre" => "Luciana Patrícia Fernandes" "apellidos" => "Abbade" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223001911" "doi" => "10.1016/j.abdp.2023.06.025" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223001911?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001587?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000006/v2_202310301240/S0365059623001587/v2_202310301240/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Therapy</span>" "titulo" => "Darier’s disease: treatment with topical sodium diclofenac 3% gel" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "882" "paginaFinal" => "884" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marcella Oliveira Menezes Quitete de Campos, Giovanna Abrantes Pimenta de Figueiredo, Allyson Capobiango Evangelista, Alexander Richard Bauk" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Marcella Oliveira Menezes Quitete de" "apellidos" => "Campos" "email" => array:1 [ 0 => "marcellamqcampos@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Giovanna Abrantes Pimenta de" "apellidos" => "Figueiredo" ] 2 => array:2 [ "nombre" => "Allyson Capobiango" "apellidos" => "Evangelista" ] 3 => array:2 [ "nombre" => "Alexander Richard" "apellidos" => "Bauk" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1840 "Ancho" => 3008 "Tamanyo" => 436156 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0060" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Dorsal region, four months after starting treatment. (B) Detail of the dorsal region, right scapular region after treatment</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 32-year-old male patient came to the authors outpatient clinic with a previous history of epilepsy and cognitive impairment, using carbamazepine and a clinical and histopathological diagnosis of Darier's disease for eight years. On physical examination, he had multiple erythematous-brown, keratotic papules, some of them crusted, located on the dorsal region, shoulders and anterior thorax (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). He had previously used topical keratolytics, corticosteroids and retinoids, in addition to systemic antibiotics, without achieving lesion control. Systemic retinoids were avoided due to possible drug interactions (carbamazepine).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">After reviewing the literature, the authors found some reports on the use of topical sodium diclofenac in Darier's disease. They chose to start with 3% sodium diclofenac and 2.5% hyaluronic acid in natrosol gel, applied twice a day only on the affected areas on the left side of the body, for eight weeks. After significant improvement of the lesions, the patient was instructed to apply it on all affected areas, twice a day. He denied local or systemic adverse reactions during medication use and no laboratory changes were observed during this period. After four months of treatment, he showed significant lesion regression, with post-inflammatory hypo- and hyperchromic macules and the presence of a few residual keratotic papules (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Medication use was reduced to once a day for another four weeks and the treatment was discontinued, with good clinical control maintained since then.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Darier's disease occurs due to a mutation in the ATP2A2 gene, which encodes a protein involved in epidermal differentiation and intercellular communication called SERCA2B, leading to impaired SERCA21 function.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> It manifests as erythematous-brown, keratotic-crusted papules, in seborrheic areas of the trunk, scalp, face, and neck associated with a foul odor and pruritus.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Ungual changes may also be observed, such as erythematous and white longitudinal bands, longitudinal fissures, subungual keratosis, and brittleness, forming “V”-shaped notches.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Treatment of Darier's disease includes general measures such as wearing light clothing and sunscreen protection; use of topical medications, such as keratolytics, corticoids, retinoids, tacrolimus, and 5-fluorouracil; and systemic drugs such as acitretin, isotretinoin, or cyclosporine. Surgical and photodynamic therapy can also be performed.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Sodium diclofenac 3% was recently described as a therapeutic option in Darier's disease.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> Its mechanism of action occurs by inhibiting cyclooxygenase-2, resulting in the suppression of prostaglandin E2 activity, which in turn downregulates the ATP2A2 gene. This leads to the normalization of SERCA2 levels in keratinocytes.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Its use is combined with hyaluronic acid 2.5%, which acts by maintaining the drug on the epidermis and superficial dermis, with better local action and less systemic absorption.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors' contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">Marcella Oliveira Menezes Quitete de Campos: Drafting and editing of the manuscript; critical review of the literature.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Giovanna Abrantes Pimenta de Figueiredo: Drafting and editing of the manuscript; critical review of the literature.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Allyson Capobiango Evangelista: Drafting and editing of the manuscript; critical review of the literature.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Alexander Richard Bauk: Approval of the final version of the manuscript; design and planning of the case report; effective participation in research orientation; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors' contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-12-29" "fechaAceptado" => "2022-01-31" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the General Outpatient Clinic of the Dermatology Service, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1840 "Ancho" => 3008 "Tamanyo" => 504468 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0055" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Dorsal region ‒ before treatment. (B) Right scapular region, before treatment</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1840 "Ancho" => 3008 "Tamanyo" => 436156 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0060" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Dorsal region, four months after starting treatment. (B) Detail of the dorsal region, right scapular region after treatment</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERC2 in keratinocytes: possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kamijo" 1 => "C. Nishiyama" 2 => "A. Takagi" 3 => "N. Nakano" 4 => "M. Hara" 5 => "S. Ikeda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2011.10789.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2011" "volumen" => "166" "paginaInicial" => "1017" "paginaFinal" => "1022" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22413864" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603138603" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improvement of Darier disease with diclofenac sodium 3% gel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Millan-Parrilla" 1 => "B. Rodrigo-Nicolas" 2 => "P. Moles-Poveda" 3 => "M. Armengot-Carbo" 4 => "E. Quecedo-Estebanez" 5 => "E. Gimeno-Carpio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2013.09.041" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2014" "volumen" => "70" "paginaInicial" => "89" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24355263" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1878875013003999" "estado" => "S300" "issn" => "18788750" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diclofenac sodium 3% gel for Darier’s disease treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Santos-Alarcon" 1 => "C. Sanchis-Sanchez" 2 => "A. Mateu-Puchades" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Online J." "fecha" => "2016" "volumen" => "22" "paginaInicial" => "17" "paginaFinal" => "20" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of Darier’s disease with diclofenac sodium 3% gel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Palacios-Alvarez" 1 => "I. Andres-Ramos" 2 => "M.Y. Silva" 3 => "G. Simal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Ther." "fecha" => "2017" "volumen" => "30" "paginaInicial" => "1" "paginaFinal" => "3" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diclofenac gel in the treatment of actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.G. Nelson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/TCRM.S12498" "Revista" => array:7 [ "tituloSerie" => "Ther Clin Risk Manag." "fecha" => "2011" "volumen" => "7" "paginaInicial" => "207" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21753882" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1878875018308635" "estado" => "S300" "issn" => "18788750" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009800000006/v2_202310301240/S0365059623001460/v2_202310301240/en/main.assets" "Apartado" => array:4 [ "identificador" => "95151" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter - Therapy" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009800000006/v2_202310301240/S0365059623001460/v2_202310301240/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001460?idApp=UINPBA00008Z" ]
| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 23 | 4 | 27 |
| 2024 Outubro | 163 | 80 | 243 |
| 2024 Setembro | 151 | 93 | 244 |
| 2024 Agosto | 164 | 114 | 278 |
| 2024 Julho | 146 | 115 | 261 |
| 2024 Junho | 161 | 78 | 239 |
| 2024 Maio | 132 | 81 | 213 |
| 2024 Abril | 143 | 104 | 247 |
| 2024 Março | 125 | 79 | 204 |
| 2024 Fevereiro | 127 | 110 | 237 |
| 2024 Janeiro | 194 | 71 | 265 |
| 2023 Dezembro | 641 | 87 | 728 |
| 2023 Novembro | 227 | 129 | 356 |
| 2023 Outubro | 276 | 112 | 388 |
| 2023 Setembro | 91 | 75 | 166 |
| 2023 Agosto | 58 | 31 | 89 |
| 2023 Julho | 75 | 60 | 135 |
| 2023 Junho | 7 | 11 | 18 |
Mostrar tudo
