que se leu este artigo
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(B) Intraoperative dermoscopy showing variation in pigmentation (brown, gray and black) of the slightly irregular lines</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Guilherme de Medeiros Holanda, Guilherme Raya Ravelli, Bruno de Carvalho Fantini, Cacilda da Silva Souza" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Guilherme de Medeiros" "apellidos" => "Holanda" ] 1 => array:2 [ "nombre" => "Guilherme Raya" "apellidos" => "Ravelli" ] 2 => array:2 [ "nombre" => "Bruno de Carvalho" "apellidos" => "Fantini" ] 3 => array:2 [ "nombre" => "Cacilda da Silva" "apellidos" => "Souza" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S266627522300139X" "doi" => "10.1016/j.abdp.2023.05.016" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S266627522300139X?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001125?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000005/v1_202307281023/S0365059623001125/v1_202307281023/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Meyerson nevus triggered by COVID-19" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "703" "paginaFinal" => "705" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Rubén Linares-Navarro, Pedro Sánchez-Sambucety, Manuel Ángel Rodríguez-Prieto" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Rubén" "apellidos" => "Linares-Navarro" "email" => array:1 [ 0 => "rlinares@saludcastillayleon.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Pedro" "apellidos" => "Sánchez-Sambucety" ] 2 => array:2 [ "nombre" => "Manuel Ángel" "apellidos" => "Rodríguez-Prieto" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, University Hospital of León, León, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1646 "Ancho" => 3341 "Tamanyo" => 1235242 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Biopsy of one of the lesions revealed nevus cells arranged in small thecae with adequate maturation without signs of dysplasia, surrounded by lymphocyte-predominant inflammatory infiltrate and marked spongiosis (Hematoxylin & eosin, ×50)</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Meyerson's nevus is an eczematous reaction on a melanocytic nevus. This reaction can also affect other types of lesions such as congenital nevi, dysplastic nevi, melanoma, and non-melanocytic lesions, in which case it is called Meyerson's phenomenon. It may be restricted to a single melanocytic nevus or affect several melanocytic nevi. In a small percentage of cases, it is accompanied by eczematous lesions in other locations. It usually resolves spontaneously or after treatment with topical corticosteroids. Its pathogenesis is not clear, and no triggers have been identified in most cases, although cases have been reported after sunburn or treatment with interferon-alpha alone or combined with ribavirin.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Multiple cutaneous manifestations caused by COVID-19 have been described. However, its pathogenesis remains unclear. They have been attributed to an inflammatory mechanism, due to an immune response against viral nucleotides, and to a vascular mechanism, secondary to vasculitis or thrombosis.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> After a rigorous search of the literature, the authors did not find any case of Meyerson's nevus associated with COVID-19 infection or vaccination.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The authors present the case of a 34-year-old man with no medical history of interest who presented to the dermatology department with erythematous-squamous lesions and crusting over approximately half of his melanocytic nevi on the trunk (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). Visualization of dermoscopic structures was difficult due to the presence of serous crusting, slight whitish scaling, and an erythematous halo (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). The previous ten days he had suffered an uncomplicated upper respiratory tract infection due to COVID-19. The patient had not experienced similar lesions after SARS‐CoV‐2 vaccination or after previous infectious processes. Nor had he introduced any new drugs.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A biopsy of one of the lesions revealed nevus cells arranged in small thecae with adequate maturation without signs of dysplasia, surrounded by lymphocyte-predominant inflammatory infiltrate (55% CD4+, 45% CD8+) and marked spongiosis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">It was diagnosed as Meyerson nevus triggered by COVID-19 infection. The lesions resolved after topical corticosteroid treatment (methylprednisolone acetate once daily for two weeks) and have not recurred to date. The affected nevi show a typical pigmented reticular pattern at present.</p><p id="par0030" class="elsevierStylePara elsevierViewall">As for nevocentric dermatoses in relation to SARS-CoV-2, a case of nevocentric erythema multiforme three days after COVID-19 vaccination (Comirnaty™ ‒ BioNTech/Pfizer ‒ Mainz, Germany/New York, NY, USA) has recently been reported.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This is a different entity than Meyerson's phenomenon, but the pathogenesis of both could involve an interaction between Intercellular Cell Adhesion Molecule 1 (ICAM-1) and CD4 T-cells. ICAM-1 expression would be stimulated by certain interferons.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> SARS-COV-2 has proved to induce a type I interferon response in a subgroup of patients with mild disease,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as in the case of our patient. This mechanism has been associated with the development of different autoimmune processes triggered by viruses and could explain the development of a Meyerson nevus coinciding with COVID-19 infection.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion, COVID-19 infection, through a mechanism mediated by ICAM-1 and interferon, could trigger Meyerson's nevus. The authors encourage the reporting of this type of skin reaction in order to consider their inclusion among the possible cutaneous manifestations related to COVID-19.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Rubén Linares-Navarro: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; manuscript critical review; preparation and writing of the manuscript; study conception and planning.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Pedro Sánchez-Sambucety: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; manuscript critical review; preparation and writing of the manuscript; study conception and planning.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Manuel Ángel Rodríguez-Prieto: Approval of the final version of the manuscript; critical literature review; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic; management of studied cases; manuscript critical review; preparation and writing of the manuscript; study conception and planning.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-09-19" "fechaAceptado" => "2022-11-08" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Department of Dermatology, University Hospital of León, León, Spain.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1635 "Ancho" => 3341 "Tamanyo" => 372228 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Erythematous-squamous lesions and crusting over approximately half of his melanocytic nevi on the trunk. (B) Visualization of dermoscopic structures was difficult due to the presence of serous crusting, slight whitish scaling, and an erythematous halo</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1646 "Ancho" => 3341 "Tamanyo" => 1235242 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Biopsy of one of the lesions revealed nevus cells arranged in small thecae with adequate maturation without signs of dysplasia, surrounded by lymphocyte-predominant inflammatory infiltrate and marked spongiosis (Hematoxylin & eosin, ×50)</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Melanocytic lesions with eczematous reaction (Meyerson’s phenomenon) - a histopathologic analysis of 64 cases: melanocytic lesions with eczematous reaction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. 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Ano/Mês | Html | Total | |
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