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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Meyerson&#39;s nevus is an eczematous reaction on a melanocytic nevus&#46; This reaction can also affect other types of lesions such as congenital nevi&#44; dysplastic nevi&#44; melanoma&#44; and non-melanocytic lesions&#44; in which case it is called Meyerson&#39;s phenomenon&#46; It may be restricted to a single melanocytic nevus or affect several melanocytic nevi&#46; In a small percentage of cases&#44; it is accompanied by eczematous lesions in other locations&#46; It usually resolves spontaneously or after treatment with topical corticosteroids&#46; Its pathogenesis is not clear&#44; and no triggers have been identified in most cases&#44; although cases have been reported after sunburn or treatment with interferon-alpha alone or combined with ribavirin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Multiple cutaneous manifestations caused by COVID-19 have been described&#46; However&#44; its pathogenesis remains unclear&#46; They have been attributed to an inflammatory mechanism&#44; due to an immune response against viral nucleotides&#44; and to a vascular mechanism&#44; secondary to vasculitis or thrombosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> After a rigorous search of the literature&#44; the authors did not find any case of Meyerson&#39;s nevus associated with COVID-19 infection or vaccination&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The authors present the case of a 34-year-old man with no medical history of interest who presented to the dermatology department with erythematous-squamous lesions and crusting over approximately half of his melanocytic nevi on the trunk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Visualization of dermoscopic structures was difficult due to the presence of serous crusting&#44; slight whitish scaling&#44; and an erythematous halo &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The previous ten days he had suffered an uncomplicated upper respiratory tract infection due to COVID-19&#46; The patient had not experienced similar lesions after SARS&#8208;CoV&#8208;2 vaccination or after previous infectious processes&#46; Nor had he introduced any new drugs&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A biopsy of one of the lesions revealed nevus cells arranged in small thecae with adequate maturation without signs of dysplasia&#44; surrounded by lymphocyte-predominant inflammatory infiltrate &#40;55&#37; CD4&#43;&#44; 45&#37; CD8&#43;&#41; and marked spongiosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">It was diagnosed as Meyerson nevus triggered by COVID-19 infection&#46; The lesions resolved after topical corticosteroid treatment &#40;methylprednisolone acetate once daily for two weeks&#41; and have not recurred to date&#46; The affected nevi show a typical pigmented reticular pattern at present&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As for nevocentric dermatoses in relation to SARS-CoV-2&#44; a case of nevocentric erythema multiforme three days after COVID-19 vaccination &#40;Comirnaty&#8482; &#8210; BioNTech&#47;Pfizer &#8210; Mainz&#44; Germany&#47;New York&#44; NY&#44; USA&#41; has recently been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This is a different entity than Meyerson&#39;s phenomenon&#44; but the pathogenesis of both could involve an interaction between Intercellular Cell Adhesion Molecule 1 &#40;ICAM-1&#41; and CD4 T-cells&#46; ICAM-1 expression would be stimulated by certain interferons&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> SARS-COV-2 has proved to induce a type I interferon response in a subgroup of patients with mild disease&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as in the case of our patient&#46; This mechanism has been associated with the development of different autoimmune processes triggered by viruses and could explain the development of a Meyerson nevus coinciding with COVID-19 infection&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; COVID-19 infection&#44; through a mechanism mediated by ICAM-1 and interferon&#44; could trigger Meyerson&#39;s nevus&#46; The authors encourage the reporting of this type of skin reaction in order to consider their inclusion among the possible cutaneous manifestations related to COVID-19&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Rub&#233;n Linares-Navarro&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; study conception and planning&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Pedro S&#225;nchez-Sambucety&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; study conception and planning&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Manuel &#193;ngel Rodr&#237;guez-Prieto&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; study conception and planning&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Letter - Clinical
Meyerson nevus triggered by COVID-19
Rubén Linares-Navarro
Autor para correspondência
rlinares@saludcastillayleon.es

Corresponding author.
, Pedro Sánchez-Sambucety, Manuel Ángel Rodríguez-Prieto
Department of Dermatology, University Hospital of León, León, Spain
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Biopsy of one of the lesions revealed nevus cells arranged in small thecae with adequate maturation without signs of dysplasia&#44; surrounded by lymphocyte-predominant inflammatory infiltrate and marked spongiosis &#40;Hematoxylin &#38; eosin&#44; &#215;50&#41;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Meyerson&#39;s nevus is an eczematous reaction on a melanocytic nevus&#46; This reaction can also affect other types of lesions such as congenital nevi&#44; dysplastic nevi&#44; melanoma&#44; and non-melanocytic lesions&#44; in which case it is called Meyerson&#39;s phenomenon&#46; It may be restricted to a single melanocytic nevus or affect several melanocytic nevi&#46; In a small percentage of cases&#44; it is accompanied by eczematous lesions in other locations&#46; It usually resolves spontaneously or after treatment with topical corticosteroids&#46; Its pathogenesis is not clear&#44; and no triggers have been identified in most cases&#44; although cases have been reported after sunburn or treatment with interferon-alpha alone or combined with ribavirin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Multiple cutaneous manifestations caused by COVID-19 have been described&#46; However&#44; its pathogenesis remains unclear&#46; They have been attributed to an inflammatory mechanism&#44; due to an immune response against viral nucleotides&#44; and to a vascular mechanism&#44; secondary to vasculitis or thrombosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> After a rigorous search of the literature&#44; the authors did not find any case of Meyerson&#39;s nevus associated with COVID-19 infection or vaccination&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The authors present the case of a 34-year-old man with no medical history of interest who presented to the dermatology department with erythematous-squamous lesions and crusting over approximately half of his melanocytic nevi on the trunk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Visualization of dermoscopic structures was difficult due to the presence of serous crusting&#44; slight whitish scaling&#44; and an erythematous halo &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The previous ten days he had suffered an uncomplicated upper respiratory tract infection due to COVID-19&#46; The patient had not experienced similar lesions after SARS&#8208;CoV&#8208;2 vaccination or after previous infectious processes&#46; Nor had he introduced any new drugs&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A biopsy of one of the lesions revealed nevus cells arranged in small thecae with adequate maturation without signs of dysplasia&#44; surrounded by lymphocyte-predominant inflammatory infiltrate &#40;55&#37; CD4&#43;&#44; 45&#37; CD8&#43;&#41; and marked spongiosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">It was diagnosed as Meyerson nevus triggered by COVID-19 infection&#46; The lesions resolved after topical corticosteroid treatment &#40;methylprednisolone acetate once daily for two weeks&#41; and have not recurred to date&#46; The affected nevi show a typical pigmented reticular pattern at present&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As for nevocentric dermatoses in relation to SARS-CoV-2&#44; a case of nevocentric erythema multiforme three days after COVID-19 vaccination &#40;Comirnaty&#8482; &#8210; BioNTech&#47;Pfizer &#8210; Mainz&#44; Germany&#47;New York&#44; NY&#44; USA&#41; has recently been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This is a different entity than Meyerson&#39;s phenomenon&#44; but the pathogenesis of both could involve an interaction between Intercellular Cell Adhesion Molecule 1 &#40;ICAM-1&#41; and CD4 T-cells&#46; ICAM-1 expression would be stimulated by certain interferons&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> SARS-COV-2 has proved to induce a type I interferon response in a subgroup of patients with mild disease&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as in the case of our patient&#46; This mechanism has been associated with the development of different autoimmune processes triggered by viruses and could explain the development of a Meyerson nevus coinciding with COVID-19 infection&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; COVID-19 infection&#44; through a mechanism mediated by ICAM-1 and interferon&#44; could trigger Meyerson&#39;s nevus&#46; The authors encourage the reporting of this type of skin reaction in order to consider their inclusion among the possible cutaneous manifestations related to COVID-19&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Rub&#233;n Linares-Navarro&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; study conception and planning&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Pedro S&#225;nchez-Sambucety&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; study conception and planning&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Manuel &#193;ngel Rodr&#237;guez-Prieto&#58; Approval of the final version of the manuscript&#59; critical literature review&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic&#59; management of studied cases&#59; manuscript critical review&#59; preparation and writing of the manuscript&#59; study conception and planning&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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