Letter - Clinical
Segmental hypopigmented acneiform nevus with FGFR2 gene mutation
Lido
3543
Vezesque se leu este artigo
1289
Total PDF
2254
Total HTML
Compartilhar estatÃsticas
array:22 [ "pii" => "S036505962300096X" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.09.021" "estado" => "S300" "fechaPublicacion" => "2023-09-01" "aid" => "765" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:17 [ "pii" => "S2666275223001236" "issn" => "26662752" "doi" => "10.1016/j.abdp.2023.04.012" "estado" => "S300" "fechaPublicacion" => "2023-09-01" "aid" => "765" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cartas ‐ Caso clínico</span>" "titulo" => "Nevo acneiforme hipopigmentado segmentar com mutação no gene <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">FGFR2</span></span>" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "710" "paginaFinal" => "712" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1626 "Ancho" => 3341 "Tamanyo" => 803208 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Nevo acneiforme sobre mancha hipopigmentada, seguindo a linha de Blaschko. (B) Comedões em detalhe, pápulas e nódulos inflamatórios. (C) Tampão folicular, pelos enrolados e hipomelanose no centro do folículo na dermatoscopia (aumento original de 10×). (D) Infundíbulo folicular dilatado e obstruído e infiltrado linfo‐histiocitário perifolicular (Hematoxilina & eosina, 100×). (E) Sequência de DNA do gene <span class="elsevierStyleItalic">FGFR2</span> do nevo acneiforme e pele contralateral não afetada do paciente é mostrada. A mutação somática em heterozigose é indicada pela seta</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yongyi Xie, Baoyi Liu, Zhouwei Wu" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Yongyi" "apellidos" => "Xie" ] 1 => array:2 [ "nombre" => "Baoyi" "apellidos" => "Liu" ] 2 => array:2 [ "nombre" => "Zhouwei" "apellidos" => "Wu" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S036505962300096X" "doi" => "10.1016/j.abd.2021.09.021" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962300096X?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223001236?idApp=UINPBA00008Z" "url" => "/26662752/0000009800000005/v1_202307310652/S2666275223001236/v1_202307310652/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059623001022" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.09.022" "estado" => "S300" "fechaPublicacion" => "2023-09-01" "aid" => "771" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Umbilical <span class="elsevierStyleItalic">lichen planus</span> induced by nivolumab" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "712" "paginaFinal" => "714" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1294 "Ancho" => 1675 "Tamanyo" => 654398 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Histological sections show an epidermis with orthokeratotic hyperkeratosis with focal parakeratosis, acanthosis with hypergranulosis, and a dense subepidermal band inflammatory infiltrate with interface dermatitis. (Hematoxylin & eosin, ×4). (B) At higher magnification, lymphocytic interface dermatitis with vacuolar degeneration of the basal layer and necrotic keratinocytes in the epidermis. (Hematoxylin & eosin, ×20)</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luisa Martos-Cabrera, Iñigo Lladó, Paloma Fernández-Rico, Beatriz Butrón-Bris, Pedro Rodríguez-Jiménez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Luisa" "apellidos" => "Martos-Cabrera" ] 1 => array:2 [ "nombre" => "Iñigo" "apellidos" => "Lladó" ] 2 => array:2 [ "nombre" => "Paloma" "apellidos" => "Fernández-Rico" ] 3 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Butrón-Bris" ] 4 => array:2 [ "nombre" => "Pedro" "apellidos" => "Rodríguez-Jiménez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223001352" "doi" => "10.1016/j.abdp.2023.05.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223001352?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001022?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000005/v1_202307281023/S0365059623001022/v1_202307281023/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0365059623000934" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.08.019" "estado" => "S300" "fechaPublicacion" => "2023-09-01" "aid" => "762" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Sarcoid reaction in eyebrow tattooing: a complication of a common cosmetic procedure" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "708" "paginaFinal" => "710" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1084 "Ancho" => 1675 "Tamanyo" => 201415 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy (×20) showing area of homogeneous orange-brown color and rarefied hairs (blue arrow) and linear vessels (yellow arrows)</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Tamires Ferri Macedo, Simone Perazzoli, Renan Rangel Bonamigo, Renata Heck" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Tamires Ferri" "apellidos" => "Macedo" ] 1 => array:2 [ "nombre" => "Simone" "apellidos" => "Perazzoli" ] 2 => array:2 [ "nombre" => "Renan Rangel" "apellidos" => "Bonamigo" ] 3 => array:2 [ "nombre" => "Renata" "apellidos" => "Heck" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223001200" "doi" => "10.1016/j.abdp.2023.04.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223001200?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000934?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000005/v1_202307281023/S0365059623000934/v1_202307281023/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Segmental hypopigmented acneiform nevus with <span class="elsevierStyleItalic">FGFR2</span> gene mutation" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "710" "paginaFinal" => "712" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Yongyi Xie, Baoyi Liu, Zhouwei Wu" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Yongyi" "apellidos" => "Xie" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Baoyi" "apellidos" => "Liu" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "Zhouwei" "apellidos" => "Wu" "email" => array:1 [ 0 => "zhouwei.wu@shgh.cn" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Shanghai General Hospital, Shanghai, China" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1626 "Ancho" => 3341 "Tamanyo" => 800814 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Acneiform nevus on hypopigmentation patch following the Blaschko line. (B) Detailed comedones, inflammatory papules and nodules. (C) Follicular plug, curled hairs, and follicle-centered hypomelanosis by Dermoscopy, ×10. (D) Dilated plugged follicular infundibula and perifollicular lymphohistiocytic infiltrate (Hematoxylin & eosin , ×100. (E) <span class="elsevierStyleItalic">FGFR2</span> DNA sequence of the acneiform nevus and contralateral unaffected skin of the patient is shown. The heterozygous somatic mutation is indicated by the arrow</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Segmental acneiform nevus associated with mutations of Fibroblast Growth Factor Receptor 2 (<span class="elsevierStyleItalic">FGFR2</span>) was first reported by Munro and Wilkie.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Very few similar cases were reported under different names making this disorder confusing. Here, the authors report a new case with a missense mutation in the <span class="elsevierStyleItalic">FGFR2</span> gene and summarized the features of this specific entity.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 13-year-old Chinese boy presented with a segmental hypopigmented patch on his left abdomen and back following the Blaschko line since birth. Since the age of 10, comedones, scattered red papules, pustules, and nodules developed on the hypopigmented patch (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A-B). Dilated follicular ostia with keratin plug, less pigmented terminal hairs with abnormal curled growth pattern, and follicle-centered hypomelanosis were identified under the Dermoscopy examination (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). During early childhood the patient had a minor delay in mental development and an attention deficit disorder, but no solid evidence of mental deficiency was found when he presented. The patient’s general health status, magnetic resonance imaging scan, skeletal X-Ray, and routine laboratory examinations were normal. Their family history was unremarkable.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Venous blood was taken from the patient and his parents, and skin biopsies from the lesional and normal skin of the patient were performed. Histological examination showed dilated plugged follicular infundibula and perifollicular lymphohistiocytic infiltrate (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). Sanger sequencing of <span class="elsevierStyleItalic">FGFR2</span> (NM_022970) detected the heterozygous mutation c.758C>G in exon 7 in the affected skin (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>E) which was neither present in unaffected skin nor in the lymphocytes from him and his parents. The sequence alteration represents a somatic mosaic mutation leading to a Pro253Arg amino acid change (CCT253CGT).</p><p id="par0020" class="elsevierStylePara elsevierViewall">Few similar cases have been reported under different names (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). A patient with mosaic <span class="elsevierStyleItalic">FGFR2</span> mutation (p.Ser252Trp) showed similar clinical symptoms.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Kiritsi et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> reported a severe case in a patient presenting with multiple segments involved. Ma et al.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> described a similar case but not confirmed by gene investigation. In addition, some documented nevus comedonicus cases with hypopigmentation may be the same disease.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Acneiform lesions are the primary feature of this entity. <span class="elsevierStyleItalic">FGFR2</span> mutation in keratinocytes could induce the hypercornification of the pilosebaceous duct and inflammatory response.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The p.Pro253Arg mutation is located in the highly conserved linker region of <span class="elsevierStyleItalic">FGFR2</span> and leads to ligand-dependent <span class="elsevierStyleItalic">FGFR2</span> activation <span class="elsevierStyleItalic">in vivo</span> due to a conformational change that increases ligand-binding affinity.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Extensive acneiform lesions, and depigmentation of hair, skin and eyes have been described in Apert syndrome in which two-thirds of patients exhibit a germline <span class="elsevierStyleItalic">FGFR2</span> mutation.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The acneiform lesions responded to treatment with isotretinoin 20 mg daily like those in Apert syndrome.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The presence of early-onset hypopigmentation is another persistent characteristic feature reported in almost all published cases except the first case in which whether there was pigmentation change was not mentioned. It could be caused by the failure of melanosome transfer from melanocytes to keratinocytes or by elevated IL-1α-mediated postinflammatory hypopigmentation.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Based on clinical and molecular data of these published cases, here, the authors propose that ‘segmental hypopigmented acneiform nevus with <span class="elsevierStyleItalic">FGFR2</span> mutation’ might be a more comprehensive description for this specific entity. In addition, the authors suggest any atypical nevus comedonicus with a feature of hypopigmentation and/or inflammatory lesion should consider this disorder and bear in mind that postzygotic mosaicism for a genetic disease such as Apert syndrome can also affect the gonads, thus resulting in a risk of transmission to offspring.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Yongyi Xie: Contribution with data collection and interpretation; preparation and writing of the manuscript; manuscript review.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Baoyi Liu: Contribution with data collection and interpretation; preparation and writing of the manuscript; manuscript review.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Zhouwei Wu: Approval of the final version of the manuscript; manuscript review.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:2 [ "identificador" => "xack679989" "titulo" => "Acknowledgments" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-08-01" "fechaAceptado" => "2021-09-23" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Shanghai General Hospital, Shanghai, China.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1626 "Ancho" => 3341 "Tamanyo" => 800814 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Acneiform nevus on hypopigmentation patch following the Blaschko line. (B) Detailed comedones, inflammatory papules and nodules. (C) Follicular plug, curled hairs, and follicle-centered hypomelanosis by Dermoscopy, ×10. (D) Dilated plugged follicular infundibula and perifollicular lymphohistiocytic infiltrate (Hematoxylin & eosin , ×100. (E) <span class="elsevierStyleItalic">FGFR2</span> DNA sequence of the acneiform nevus and contralateral unaffected skin of the patient is shown. The heterozygous somatic mutation is indicated by the arrow</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age at onset \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age at diagnosis \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Distribution of lesions \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Morphology of lesions \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mutation \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single segmental (left arm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mostly comedones with scattered inflammatory papules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">FGFR2</span> mutation (p.Ser252Trp) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Multiple segmental (right chest, trunk, shoulder, and arm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Multiple comedones, inflammatory papules and pustules with hypopigmentation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">FGFR2</span> mutation (p.Ser252Trp) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Multiple segmental (left and right sides of chest, trunk, shoulders, arms, and right face) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Multiple comedones, inflammatory papules, pustules, nodules, scars with hypopigmentation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">FGFR2</span> mutation (p.Pro253Arg) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ours \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single segmental (left abdomen and back) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Multiple comedones and inflammatory papules, pustules, nodules with hypopigmentation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">FGFR2</span> mutation (p.Pro253Arg) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single segmental (right chest and back) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mostly comedones with scattered inflammatory papules with hypopigmentation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3232833.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Main features of published cases of a segmental acneiform nevus with hypopigmentation</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal mosaicism producing localized acne: somatic mutation in FGFR2" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.S. Munro" 1 => "A.O. Wilkie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)60820-3" "Revista" => array:6 [ "tituloSerie" => "Lancet." "fecha" => "1998" "volumen" => "352" "paginaInicial" => "704" "paginaFinal" => "705" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9728990" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unilateral segmental acneiform naevus: a model disorder towards understanding fibroblast growth factor receptor 2 function in acne?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.C. Melnik" 1 => "F. Vakilzadeh" 2 => "C. Aslanidis" 3 => "G. Schmitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08558.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2008" "volumen" => "158" "paginaInicial" => "1397" "paginaFinal" => "1399" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18410419" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blaschko line acne on pre-existent hypomelanosis reflecting a mosaic FGFR2 mutation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Kiritsi" 1 => "A.I. Lorente" 2 => "R. Happle" 3 => "J.B. Wittel" 4 => "C. Has" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.13491" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2015" "volumen" => "172" "paginaInicial" => "1125" "paginaFinal" => "1127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25350236" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unilateral keratosis pilaris occurring on linear hypopigmentation patches: a new variant of keratosis pilaris in an Asian?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Ma" 1 => "Q. Xu" 2 => "G. Zhu" 3 => "X. Su" 4 => "S. Yin" 5 => "C. Lu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1346-8138.12821" "Revista" => array:6 [ "tituloSerie" => "J Dermatol." "fecha" => "2015" "volumen" => "42" "paginaInicial" => "437" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25753262" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Segmental acne versus mosaic conditions with acne lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Torchia" 1 => "L.A. Schachner" 2 => "J. Izakovic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000336797" "Revista" => array:6 [ "tituloSerie" => "Dermatology." "fecha" => "2012" "volumen" => "224" "paginaInicial" => "10" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22456681" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extensive acne in Apert syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.M.B. Steglich" 1 => "R.B. Steglich" 2 => "M.M. Melo" 3 => "H.L. Almeida Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2011.05134.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol." "fecha" => "2016" "volumen" => "55" "paginaInicial" => "e596" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27428282" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack679989" "titulo" => "Acknowledgments" "texto" => "<p id="par0065" class="elsevierStylePara elsevierViewall">The authors thank the patient and his family. The authors also thank Dr. Ming Li from Xinhu hospital, Shanghai Jiaotong university for their expert consultation.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009800000005/v1_202307281023/S036505962300096X/v1_202307281023/en/main.assets" "Apartado" => array:4 [ "identificador" => "95153" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter - Clinical" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009800000005/v1_202307281023/S036505962300096X/v1_202307281023/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962300096X?idApp=UINPBA00008Z" ]
| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 16 | 6 | 22 |
| 2024 Outubro | 128 | 56 | 184 |
| 2024 Setembro | 165 | 91 | 256 |
| 2024 Agosto | 193 | 114 | 307 |
| 2024 Julho | 141 | 96 | 237 |
| 2024 Junho | 178 | 79 | 257 |
| 2024 Maio | 159 | 61 | 220 |
| 2024 Abril | 124 | 80 | 204 |
| 2024 Março | 107 | 65 | 172 |
| 2024 Fevereiro | 101 | 80 | 181 |
| 2024 Janeiro | 79 | 61 | 140 |
| 2023 Dezembro | 91 | 69 | 160 |
| 2023 Novembro | 120 | 94 | 214 |
| 2023 Outubro | 123 | 103 | 226 |
| 2023 Setembro | 160 | 87 | 247 |
| 2023 Agosto | 220 | 51 | 271 |
| 2023 Julho | 69 | 27 | 96 |
| 2023 Junho | 46 | 33 | 79 |
| 2023 Maio | 34 | 36 | 70 |
Mostrar tudo
