Letter - Clinical
Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia formation
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(A) Erosões no palato mole e duro. (B) Milia observada sobre lesões erosivas de PV no ombro (<span class="elsevierStyleItalic">setas</span>).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sebastian Vernal, Roberto Bueno‐Filho, Takashi Hashimoto, Ana Maria Roselino" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Sebastian" "apellidos" => "Vernal" ] 1 => array:2 [ "nombre" => "Roberto" "apellidos" => "Bueno‐Filho" ] 2 => array:2 [ "nombre" => "Takashi" "apellidos" => "Hashimoto" ] 3 => array:2 [ "nombre" => "Ana Maria" "apellidos" => "Roselino" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059623000636" "doi" => "10.1016/j.abd.2021.09.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000636?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223000905?idApp=UINPBA00008Z" "url" => "/26662752/0000009800000004/v2_202307101646/S2666275223000905/v2_202307101646/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059623000466" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.01.015" "estado" => "S300" "fechaPublicacion" => "2023-07-01" "aid" => "727" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Perniosis-like erythema after SARS-CoV2 infection reactivated by vaccination with inactivated virus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "552" "paginaFinal" => "554" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1124 "Ancho" => 1508 "Tamanyo" => 114314 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Persistence of acrocyanosis and full resolution of papules.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lucas Campos Garcia, Vanessa Martins Barcelos, Myrciara Macedo de Alcântara, Priscila Jordana Costa Valadares" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Lucas" "apellidos" => "Campos Garcia" ] 1 => array:2 [ "nombre" => "Vanessa Martins" "apellidos" => "Barcelos" ] 2 => array:2 [ "nombre" => "Myrciara" "apellidos" => "Macedo de Alcântara" ] 3 => array:2 [ "nombre" => "Priscila Jordana Costa" "apellidos" => "Valadares" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223000553" "doi" => "10.1016/j.abdp.2023.03.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223000553?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000466?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000004/v1_202307031010/S0365059623000466/v1_202307031010/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0365059623000582" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.08.016" "estado" => "S300" "fechaPublicacion" => "2023-07-01" "aid" => "739" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Keloid formation following ear piercing through the transitional zone" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "548" "paginaFinal" => "550" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1856 "Ancho" => 2508 "Tamanyo" => 319794 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Keloid formation following piercing through the transitional zone in patient 1 (A) and patient 2 (B). There is no keloid formation at the earlobe piercing points in both patients.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ozge Zorlu, Serkan Yazici, Şaduman Balaban Adım" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ozge" "apellidos" => "Zorlu" ] 1 => array:2 [ "nombre" => "Serkan" "apellidos" => "Yazici" ] 2 => array:2 [ "nombre" => "Şaduman" "apellidos" => "Balaban Adım" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223000851" "doi" => "10.1016/j.abdp.2023.03.017" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223000851?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000582?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000004/v1_202307031010/S0365059623000582/v1_202307031010/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia formation" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor,</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "550" "paginaFinal" => "552" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sebastian Vernal, Roberto Bueno-Filho, Takashi Hashimoto, Ana Maria Roselino" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Sebastian" "apellidos" => "Vernal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Roberto" "apellidos" => "Bueno-Filho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Takashi" "apellidos" => "Hashimoto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:4 [ "nombre" => "Ana Maria" "apellidos" => "Roselino" "email" => array:1 [ 0 => "amfrosel@fmrp.usp.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Dermatology Division, Department of Clinical Medicine, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1111 "Ancho" => 2508 "Tamanyo" => 314216 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical features of the present case. (A) Erosions on the soft and hard palate. (B) Milia seen over previously erosive PV lesions on the shoulder (arrows).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report a 60-year-old woman who was diagnosed with pemphigus vulgaris (PV) associated with uncommon presentations, i.e., nasal mucosal involvement with septal perforation, ocular conjunctival involvement of herpes simplex virus (HSV) infection, and milia on the re-epithelialized skin. We will discuss each association based on the results of our laboratory examinations.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Clinical examination revealed erosive skin lesions mainly on the face, trunk, and limbs, as well as mucosal lesions on the tongue, gingivae, and palate (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), and hyperemia on the left conjunctiva. Erosions and crusts in the nasal mucosa, and anterior nasoseptal perforation were also detected. Additionally, milia were observed on the skin of the face and shoulders, which were previously affected by PV (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathology showed suprabasal acantholysis for biopsies taken from the chest and from the nasal septum (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). IgG deposition on keratinocyte cell surfaces was detected on direct immunofluorescence (DIF) using Tzanck smears from oral mucosa (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B), which suggested PV. Anti-herpes simplex virus (HSV)-1 antibody (Abcam, Cambridge, USA) on DIF using scraped smears showed negative staining in oral mucosa but positive nuclear staining in ocular conjunctiva (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>C), while immunohistochemistry using nasal mucosa biopsy showed negative HSV staining. Polymerase-chain-reaction for <span class="elsevierStyleItalic">Leishmania</span> sp., <span class="elsevierStyleItalic">Mycobacterium</span> sp., <span class="elsevierStyleItalic">M</span>. <span class="elsevierStyleItalic">tuberculosis</span> and <span class="elsevierStyleItalic">M</span>. <span class="elsevierStyleItalic">leprae</span>, and fungal culture from nasal mucosa samples were negative.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Antinuclear antibody, HIV and VDRL serologies were negative. indirect immunofluorescence (IIF) using a normal human skin section detected IgG anti-keratinocyte cell surface antibodies. IIF on 1M-NaCl-split-skin was negative in the basement membrane zone.</p><p id="par0025" class="elsevierStylePara elsevierViewall">ELISA (MBL, Japan) was positive for desmoglein (Dsg) 1 (112.7 U/mL) and Dsg3 (39.3 U/mL) (cut-off 20 U/mL), but negative for BP180 (4.21 U/mL) and BP230 (1.51 U/mL) (cut-off 9 U/mL). Immunoblotting analyses using normal human epidermal and dermal extracts, recombinant proteins of BP180 NC16a and C-terminal domains, concentrated culture supernatant of HaCaT cells, and purified human laminin – 332 were all negative.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient underwent three monthly cycles of pulse therapy (dexamethasone and cyclophosphamide), followed by oral prednisone 12.5<span class="elsevierStyleHsp" style=""></span>mg/day, and cyclophosphamide 50<span class="elsevierStyleHsp" style=""></span>mg/day. Acyclovir was also given. Skin lesions quickly disappeared. All the mucosal lesions gradually improved.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Nasal mucosal involvement in PV has rarely been reported<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>. In this case, histopathology showed suprabasal acantholysis in nasal mucosa biopsy. Collagen disease and infections of HIV, syphilis, HSV, leishmaniasis, leprosy, and fungus were excluded<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>. We suppose that the nasoseptal perforation was attributed secondarily to repetitive traumatic manipulation for PV-induced nasal mucosal crusts.</p><p id="par0040" class="elsevierStylePara elsevierViewall">DIF on the Tzanck smear suggested HSV-1 infection for the left conjunctival lesion, and the conjunctival lesions improved after acyclovir treatment. HSV-1 infection was occasionally observed on the oral mucosa<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>, but not on the ocular conjunctiva, in PV.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Finally, our patient showed milium formation in skin previously affected by PV. Therefore, we also performed various IIF, ELISA, and immunoblotting analyses, which excluded the diagnoses of epidermolysis bullosa acquisita and bullous pemphigoid, the diseases commonly developing milia<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion, although PV is a prevalent disease in Southeastern Brazil<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>, this is the first PV case with nasoseptal perforation, conjunctival herpetic infection and milium-associated features.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0055" class="elsevierStylePara elsevierViewall">This study was partially supported by <span class="elsevierStyleGrantSponsor" id="gs0005">FAPESP</span> (Fundação de Amparo à Pesquisa do Estado de São Paulo), process number <span class="elsevierStyleGrantNumber" refid="gs0005">2010/51729-2</span>, and by <span class="elsevierStyleGrantSponsor" id="gs0010">FAEPA</span> (Fundação de Apoio ao Ensino, Pesquisa e Assistência). SV received a PhD scholarship from <span class="elsevierStyleGrantSponsor" id="gs0015">CAPES</span> (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors' contributions</span><p id="par0060" class="elsevierStylePara elsevierViewall">Sebastian Vernal: Has contributed with collection and interpretation of data, writing the manuscript, effective participation, literature review, final approval of the final version of the manuscript.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Roberto Bueno-Filho: Has contributed with collection and interpretation of data, effective participation, participation of therapeutic conduct of the studied cases, final approval of the final version of the manuscript.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Takashi Hashimoto: Has contributed with collection and interpretation of data, effective participation, writing the manuscript, final approval of the final version of the manuscript.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Ana Maria Roselino: Has contributed with the study concept and design, collection, and interpretation of data, writing the manuscript, effective participation, literature review, participation of therapeutic conduct of the studied cases, final approval of the final version of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors' contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:2 [ "identificador" => "xack673915" "titulo" => "Acknowledgments" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-08-15" "fechaAceptado" => "2021-09-20" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Laboratory of Dermatology, University Hospital, Ribeirão Preto Medical School, University of São Paulo, Brazil, and at the Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1111 "Ancho" => 2508 "Tamanyo" => 314216 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical features of the present case. (A) Erosions on the soft and hard palate. (B) Milia seen over previously erosive PV lesions on the shoulder (arrows).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 911 "Ancho" => 3341 "Tamanyo" => 341184 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0040" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathological and immunofluorescence findings. (A) Suprabasal acantholysis in biopsy taken from nasal mucosa (Hematoxylin & eosin, ×63). (B) Positive reactivity in oral mucosal cell surfaces with FITC-conjugated anti-human IgG antibody using Direct Immunofluorescence (DIF) on Tzanck smears taken from oral mucosae (×63). (C) DIF using ocular conjunctival scraped smears with FITC-conjugated anti-HSV-1 antibody showing positive nuclear staining (×100).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nasal, oral, and pharyngolaryngeal manifestations of pemphigus vulgaris: Endoscopic ororhinolaryngologic examination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Ohki" 1 => "S. 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Roselino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/exd.13342" "Revista" => array:6 [ "tituloSerie" => "Exp Dermatol" "fecha" => "2017" "volumen" => "26" "paginaInicial" => "966" "paginaFinal" => "968" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28370424" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Vernal" 1 => "E.V. Oliveira" 2 => "R. Bueno Filho" 3 => "T.A. Julio" 4 => "E.A. Donadi" 5 => "A. Turatti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.abd.2021.10.003" "Revista" => array:6 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2022" "volumen" => "97" "paginaInicial" => "435" "paginaFinal" => "442" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35637051" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spatial Distribution of Pemphigus Occurrence over Five Decades in Southeastern Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.S. Celere" 1 => "S. Vernal" 2 => "L. La Serra" 3 => "M.J. Franco Brochado" 4 => "L.E. Moschini" 5 => "A.M. Roselino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4269/ajtmh.17-0100" "Revista" => array:6 [ "tituloSerie" => "Am J Trop Med Hyg" "fecha" => "2017" "volumen" => "97" "paginaInicial" => "1737" "paginaFinal" => "1745" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29016334" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack673915" "titulo" => "Acknowledgments" "texto" => "<p id="par0085" class="elsevierStylePara elsevierViewall">We thank the medical staff, especially Dr. Daiane Pess, of the autoimmune dermatoses’ outpatient clinics at the University Hospital of Ribeirão Preto Medical School, University of São Paulo. We are grateful to Dr. Norito Ishii, Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology for various serological studies for autoantibodies and autoantigens. We also thank Aline Turatti, PhD, University Hospital of Ribeirão Preto Medical School, University of São Paulo, for technical assistance for direct and indirect immunofluorescence.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009800000004/v1_202307031010/S0365059623000636/v1_202307031010/en/main.assets" "Apartado" => array:4 [ "identificador" => "95691" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter – Clinical" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009800000004/v1_202307031010/S0365059623000636/v1_202307031010/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000636?idApp=UINPBA00008Z" ]
| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 15 | 7 | 22 |
| 2024 Outubro | 104 | 88 | 192 |
| 2024 Setembro | 145 | 89 | 234 |
| 2024 Agosto | 164 | 120 | 284 |
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| 2024 Junho | 99 | 73 | 172 |
| 2024 Maio | 103 | 52 | 155 |
| 2024 Abril | 105 | 93 | 198 |
| 2024 Março | 114 | 70 | 184 |
| 2024 Fevereiro | 95 | 76 | 171 |
| 2024 Janeiro | 69 | 52 | 121 |
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| 2023 Novembro | 92 | 101 | 193 |
| 2023 Outubro | 109 | 81 | 190 |
| 2023 Setembro | 98 | 91 | 189 |
| 2023 Agosto | 88 | 33 | 121 |
| 2023 Julho | 193 | 57 | 250 |
| 2023 Junho | 66 | 38 | 104 |
| 2023 Maio | 47 | 29 | 76 |
| 2023 Abril | 33 | 25 | 58 |
| 2023 Março | 18 | 17 | 35 |
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