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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pemphigus vulgaris &#40;PV&#41; affects mainly the mucous membranes&#44; through the production of autoantibodies against desmoglein &#40;Dsg&#41; 3&#46; Anti-Dsg1 and anti-Dsg3 autoantibodies are produced in the mucocutaneous form of the disease&#46; The incidence of PV has been increasing in the northeastern region of the state of S&#227;o Paulo&#44; Brazil&#44; an endemic region for pemphigus foliaceus &#40;PF&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Susceptible&#47;protective HLA alleles for PV&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> agricultural activities&#44; and&#44; more recently&#44; salivary proteins from insect bites<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> have been described in association with PV&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Reports of monozygotic twins affected by PV are rare<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The present report describes the third case of monozygotic twin sisters&#44; 43-years-old&#44; of which only one developed PV&#46; In September 2018&#44; the twin with PV had multiple oral erosions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; Direct Immunofluorescence &#40;DIF&#41; on the Tzanck smear showed fluorescence with anti-IgG on the keratinocytes cell membrane &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#59; the oral mucosal biopsy demonstrated acantholytic suprabasal bullae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>c&#41;&#46; Multinucleated keratinocytes suggestive of HSV infection were also observed in the Tzanck smear&#46; DIF on the skin biopsy and indirect immunofluorescence &#40;IIF&#41; with normal skin substrate presented fluorescence with anti-IgG on the keratinocytes cell membrane&#46; Prednisone 40&#8239;mg&#47;day&#44; dapsone 50&#8239;mg&#47;day&#44; and folic acid 5&#8239;mg&#47;day were prescribed&#46; After a few days&#44; lesions appeared on the abdomen&#44; anterior chest region&#44; and back &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>d&#41;&#44; with the presence of Nikolsky sign&#46; Biopsy of the lesion on the back showed the presence of an acantholytic suprabasal bulla on histopathology&#44; and interkeratinocyte fluorescence for IgG and C3 on DIF&#46; After eight months of treatment&#44; dapsone was replaced by cyclophosphamide at 50&#8239;mg&#47;day&#46; In March 2020&#44; the patient suspended the medication due to the coronavirus pandemic&#46; In June 2020&#44; the oral lesions recurred and prednisone was restarted&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">When the patient had exclusive mucosal lesions&#44; the ELISA test resulted in anti-Dsg1 2&#46;0 U&#47;mL and anti-Dsg3 189&#46;1 U&#47;mL &#40;MBL&#44; Japan&#44; cutoff of 20 U&#47;mL for both&#41;&#44; while her sister showed negative values &#8203;&#8203;on ELISA &#40;1&#46;6 U&#47;mL and 0&#46;7 U&#47;mL&#44; respectively&#41; and IIF&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Both sisters had two HLA susceptibility alleles for PV&#58; <span class="elsevierStyleItalic">HLA-DRB1</span>&#42;08&#58;04 and <span class="elsevierStyleItalic">HLA-DRB1</span>&#42;14&#58;01&#44; while the <span class="elsevierStyleItalic">HLA-DQA1</span> alleles were not associated with PV&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Moreover&#44; they had two other alleles&#44; <span class="elsevierStyleItalic">HLA-DQB1</span>&#42;03&#58;01&#44; and <span class="elsevierStyleItalic">HLA-DQB1</span>&#42;05&#58;01&#44; which have been described in association with resistance and susceptibility to PF&#44; respectively<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Two years later&#44; only one of the twins had PV&#46; Although they had an identical HLA profile&#44; they had not been exposed to similar environmental factors&#46; Both lived in a region prevalent for PV&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in the northeastern region of the state of S&#227;o Paulo&#44; Brazil&#46; However&#44; the affected sister had worked in rural activities&#44; on a chicken farm&#44; for 10 years&#44; while her unaffected twin sister reported having always worked in the urban area&#46; Rural workers are more exposed to pesticides&#44; as well as to another possible PV trigger &#8211; blood-sucking insect bites&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">When evaluating the HLA profile and environmental factors in PV triggering&#44; one can detect&#44; in advance&#44; those individuals who are most likely to develop the disease&#46; And the question arises whether by modifying the contributing factors&#44; whenever possible&#44; one could prevent the emergence of PV&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; the genotype-environmental factor interactions need to be further explored in the pathogenesis of pemphigus&#44; and the present report illustrates this scenario&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">This work was partially supported by <span class="elsevierStyleGrantSponsor" id="gs0005">FAPESP</span> &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo</span>&#59; <span class="elsevierStyleGrantNumber" refid="gs0005">&#35;2010&#47;51729-2</span>&#41; and <span class="elsevierStyleGrantSponsor" id="gs0010">FAEPA</span> &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Apoio ao Ensino&#44; Pesquisa e Assist&#234;ncia</span>&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#39; contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Marcela Rosa de Almeida Farid&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the literature&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Roberto Bueno-Filho&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Eduardo Ant&#244;nio Donadi&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Ana Maria Roselino&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">IIF&#44; Indirect immunofluorescence&#59; Dsg&#44; Desmoglein&#59; ND&#44; Not determined&#59; NA&#44; Not affected&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical form of pemphigus vulgaris&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IIF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-Dsg1 &#40;U&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-Dsg3 &#40;U&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HLA Alleles&#47;haplotypes<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ruocco et al&#46; &#40;1985&#41;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Italy</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mucocutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#189;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#58;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">A</span>&#42;24&#44; <span class="elsevierStyleItalic">A</span>&#42;29&#59; <span class="elsevierStyleItalic">B</span>&#42;45&#44; B&#42;35&#59; <span class="elsevierStyleItalic">C</span>&#42;04&#44; C&#42;x&#59; <span class="elsevierStyleItalic">DRB1</span>&#42;04&#44; <span class="elsevierStyleItalic">DRB1</span>&#42;07</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not affected<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#58;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Salathiel et al&#46; &#40;2016&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mucocutaneous</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DRB1</span></span><span class="elsevierStyleUnderline">&#42;04&#58;02</span>-<span class="elsevierStyleUnderline">D</span><span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">QA1</span></span><span class="elsevierStyleUnderline">&#42;03&#58;01</span>-<span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DQB1</span></span><span class="elsevierStyleUnderline">&#42;03&#58;02</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DRB1</span></span><span class="elsevierStyleUnderline">&#42;14&#58;04</span>-<span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DQA1</span></span><span class="elsevierStyleUnderline">&#42;01&#58;01</span>-<span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DQB1</span></span><span class="elsevierStyleUnderline">&#42;05&#58;03</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Farid et al&#46; &#40;2021&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mucocutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;0&#177;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">189&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                      "titulo" => "Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region"
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                      "titulo" => "Image Gallery&#58; A case of pemphigus vulgaris following Simulium spp&#46; &#40;Diptera&#41; bites"
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                            3 => "A&#46;G&#46; Ara&#250;jo"
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        "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">The authors would like to thank Dr&#46; Leticia Arruda Camargo and Tamiris Amanda Julio&#44; PhD&#44; for their contribution in the preparation of the clinical case and in the assessment of anti-desmogleins by ELISA&#44; respectively&#46;</p>"
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Case Letter
Pemphigus vulgaris with exclusive manifestation in one of monozygotic twins: could environmental factors be involved?
Marcela Rosa de Almeida Farid, Roberto Bueno-Filho, Eduardo Antônio Donadi, Ana Maria Roselino
Autor para correspondência
amfrosel@fmrp.usp.br

Corresponding author.
Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil
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    "titulo" => "Pemphigus vulgaris with exclusive manifestation in one of monozygotic twins&#58; could environmental factors be involved&#63;"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41;&#44; Lesions on the oral mucosa&#58; erosions on the tongue covered by a whitish pseudomembrane&#44; erosions on the labial mucosa&#44; erosions and crusts on the lower lip&#46; &#40;B&#41;&#44; Direct immunofluorescence on oral Tzanck smear cytology&#58; fluorescence with anti-IgG on the keratinocytes cell membrane&#46; &#40;C&#41;&#44; Histopathology of the oral mucosa &#40;Hematoxylin &#38; eosin&#44; &#215;40&#41;&#58; acantholytic suprabasal bulla&#46; &#40;D&#41;&#44; Skin lesions&#58; erythematous plaques on the abdomen and chest with bullae&#44; erosions and hematic crusts&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pemphigus vulgaris &#40;PV&#41; affects mainly the mucous membranes&#44; through the production of autoantibodies against desmoglein &#40;Dsg&#41; 3&#46; Anti-Dsg1 and anti-Dsg3 autoantibodies are produced in the mucocutaneous form of the disease&#46; The incidence of PV has been increasing in the northeastern region of the state of S&#227;o Paulo&#44; Brazil&#44; an endemic region for pemphigus foliaceus &#40;PF&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Susceptible&#47;protective HLA alleles for PV&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> agricultural activities&#44; and&#44; more recently&#44; salivary proteins from insect bites<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> have been described in association with PV&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Reports of monozygotic twins affected by PV are rare<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The present report describes the third case of monozygotic twin sisters&#44; 43-years-old&#44; of which only one developed PV&#46; In September 2018&#44; the twin with PV had multiple oral erosions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; Direct Immunofluorescence &#40;DIF&#41; on the Tzanck smear showed fluorescence with anti-IgG on the keratinocytes cell membrane &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#59; the oral mucosal biopsy demonstrated acantholytic suprabasal bullae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>c&#41;&#46; Multinucleated keratinocytes suggestive of HSV infection were also observed in the Tzanck smear&#46; DIF on the skin biopsy and indirect immunofluorescence &#40;IIF&#41; with normal skin substrate presented fluorescence with anti-IgG on the keratinocytes cell membrane&#46; Prednisone 40&#8239;mg&#47;day&#44; dapsone 50&#8239;mg&#47;day&#44; and folic acid 5&#8239;mg&#47;day were prescribed&#46; After a few days&#44; lesions appeared on the abdomen&#44; anterior chest region&#44; and back &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>d&#41;&#44; with the presence of Nikolsky sign&#46; Biopsy of the lesion on the back showed the presence of an acantholytic suprabasal bulla on histopathology&#44; and interkeratinocyte fluorescence for IgG and C3 on DIF&#46; After eight months of treatment&#44; dapsone was replaced by cyclophosphamide at 50&#8239;mg&#47;day&#46; In March 2020&#44; the patient suspended the medication due to the coronavirus pandemic&#46; In June 2020&#44; the oral lesions recurred and prednisone was restarted&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">When the patient had exclusive mucosal lesions&#44; the ELISA test resulted in anti-Dsg1 2&#46;0 U&#47;mL and anti-Dsg3 189&#46;1 U&#47;mL &#40;MBL&#44; Japan&#44; cutoff of 20 U&#47;mL for both&#41;&#44; while her sister showed negative values &#8203;&#8203;on ELISA &#40;1&#46;6 U&#47;mL and 0&#46;7 U&#47;mL&#44; respectively&#41; and IIF&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Both sisters had two HLA susceptibility alleles for PV&#58; <span class="elsevierStyleItalic">HLA-DRB1</span>&#42;08&#58;04 and <span class="elsevierStyleItalic">HLA-DRB1</span>&#42;14&#58;01&#44; while the <span class="elsevierStyleItalic">HLA-DQA1</span> alleles were not associated with PV&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Moreover&#44; they had two other alleles&#44; <span class="elsevierStyleItalic">HLA-DQB1</span>&#42;03&#58;01&#44; and <span class="elsevierStyleItalic">HLA-DQB1</span>&#42;05&#58;01&#44; which have been described in association with resistance and susceptibility to PF&#44; respectively<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Two years later&#44; only one of the twins had PV&#46; Although they had an identical HLA profile&#44; they had not been exposed to similar environmental factors&#46; Both lived in a region prevalent for PV&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in the northeastern region of the state of S&#227;o Paulo&#44; Brazil&#46; However&#44; the affected sister had worked in rural activities&#44; on a chicken farm&#44; for 10 years&#44; while her unaffected twin sister reported having always worked in the urban area&#46; Rural workers are more exposed to pesticides&#44; as well as to another possible PV trigger &#8211; blood-sucking insect bites&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">When evaluating the HLA profile and environmental factors in PV triggering&#44; one can detect&#44; in advance&#44; those individuals who are most likely to develop the disease&#46; And the question arises whether by modifying the contributing factors&#44; whenever possible&#44; one could prevent the emergence of PV&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; the genotype-environmental factor interactions need to be further explored in the pathogenesis of pemphigus&#44; and the present report illustrates this scenario&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">This work was partially supported by <span class="elsevierStyleGrantSponsor" id="gs0005">FAPESP</span> &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo</span>&#59; <span class="elsevierStyleGrantNumber" refid="gs0005">&#35;2010&#47;51729-2</span>&#41; and <span class="elsevierStyleGrantSponsor" id="gs0010">FAEPA</span> &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o de Apoio ao Ensino&#44; Pesquisa e Assist&#234;ncia</span>&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#39; contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Marcela Rosa de Almeida Farid&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the literature&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Roberto Bueno-Filho&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Eduardo Ant&#244;nio Donadi&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Ana Maria Roselino&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">A</span>&#42;24&#44; <span class="elsevierStyleItalic">A</span>&#42;29&#59; <span class="elsevierStyleItalic">B</span>&#42;45&#44; B&#42;35&#59; <span class="elsevierStyleItalic">C</span>&#42;04&#44; C&#42;x&#59; <span class="elsevierStyleItalic">DRB1</span>&#42;04&#44; <span class="elsevierStyleItalic">DRB1</span>&#42;07</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not affected<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#58;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Salathiel et al&#46; &#40;2016&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mucocutaneous</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DRB1</span></span><span class="elsevierStyleUnderline">&#42;04&#58;02</span>-<span class="elsevierStyleUnderline">D</span><span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">QA1</span></span><span class="elsevierStyleUnderline">&#42;03&#58;01</span>-<span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DQB1</span></span><span class="elsevierStyleUnderline">&#42;03&#58;02</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DRB1</span></span><span class="elsevierStyleUnderline">&#42;14&#58;04</span>-<span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DQA1</span></span><span class="elsevierStyleUnderline">&#42;01&#58;01</span>-<span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DQB1</span></span><span class="elsevierStyleUnderline">&#42;05&#58;03</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Farid et al&#46; &#40;2021&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mucocutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;0&#177;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">189&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DRB1</span></span><span class="elsevierStyleUnderline">&#42;08&#58;04</span>&#44; <span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">DRB1</span></span><span class="elsevierStyleUnderline">&#42;14&#58;01</span>&#59; <span class="elsevierStyleItalic">DQA1</span>&#42;01&#58;01&#44; <span class="elsevierStyleItalic">DQA1</span>&#42;05&#58;01&#59; <span class="elsevierStyleItalic">DQB1</span>&#42;03&#58;01<span class="elsevierStyleSup">&#43;</span>&#44; <span class="elsevierStyleItalic">DQB1</span>&#42;05&#58;01<span class="elsevierStyleSup">&#43;&#43;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brazil &#40;current&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Twin 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not affected<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">At 23 years old&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">At 45 years old&#59; &#177; anti-Dsg1 titer when the patient had exclusive oral lesions&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">PV susceptibility alleles are underlined&#59; resistance&#8239;&#43;&#8239;and susceptibility&#43;&#43; alleles to pemphigus foliaceus &#40;see Ref&#46; <a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Clinical and laboratory data obtained from the literature on monozygotic twins presenting with pemphigus vulgaris&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;S&#46; Celere"
                            1 => "S&#46; Vernal"
                            2 => "M&#46;J&#46;F&#46; Brochado"
                            3 => "S&#46;I&#46; Segura-Mu&#241;oz"
                            4 => "A&#46;M&#46; Roselino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ijd.13714"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "56"
                        "paginaInicial" => "1494"
                        "paginaFinal" => "1496"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28737218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Brochado"
                            1 => "D&#46;F&#46; Nascimento"
                            2 => "W&#46; Campos"
                            3 => "N&#46;H&#46;S&#46; Deghaide"
                            4 => "E&#46;A&#46; Donadi"
                            5 => "A&#46;M&#46; Roselino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaut.2016.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Autoimmun&#46;"
                        "fecha" => "2016"
                        "volumen" => "72"
                        "paginaInicial" => "19"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27178774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Image Gallery&#58; A case of pemphigus vulgaris following Simulium spp&#46; &#40;Diptera&#41; bites"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;G&#46; Wambier"
                            1 => "T&#46;A&#46; Struecker"
                            2 => "L&#46;N&#46; Durski"
                            3 => "A&#46;G&#46; Ara&#250;jo"
                            4 => "S&#46;P&#46;F&#46; Wambier"
                            5 => "M&#46;A&#46; Cappel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.15393"
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "176"
                        "paginaInicial" => "e100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28504401"
                            "web" => "Medline"
                          ]
                        ]
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            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pemphigus vulgaris in only one of two monozygotic twins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Ruocco"
                            1 => "G&#46; Peluso"
                            2 => "M&#46; Pisani"
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                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0190-9622(85)80104-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "1985"
                        "volumen" => "12"
                        "paginaInicial" => "587"
                        "paginaFinal" => "589"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
                          ]
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            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Family study of monozygotic twins affected by pemphigus vulgaris"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Salathiel"
                            1 => "M&#46;J&#46; Brochado"
                            2 => "O&#46; Kim"
                            3 => "N&#46;H&#46;S&#46; Deghaide"
                            4 => "E&#46;A&#46; Donadi"
                            5 => "A&#46;M&#46; Roselino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.humimm.2016.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Immunol&#46;"
                        "fecha" => "2016"
                        "volumen" => "77"
                        "paginaInicial" => "600"
                        "paginaFinal" => "604"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27177496"
                            "web" => "Medline"
                          ]
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                      ]
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      0 => array:4 [
        "identificador" => "xack623238"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">The authors would like to thank Dr&#46; Leticia Arruda Camargo and Tamiris Amanda Julio&#44; PhD&#44; for their contribution in the preparation of the clinical case and in the assessment of anti-desmogleins by ELISA&#44; respectively&#46;</p>"
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      ]
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