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with the presence of a high number of atypical melanocytes in the basal layer of the epidermis and peri-adnexal extension associated with solar elastosis and epidermal thinning&#44; due to the intense solar damage of the areas where these lesions originate&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">One of the difficulties in the treatment of LM is to define the true clinical and histopathological lesion extension&#44; as they present extended areas&#44; that is&#44; they can extend beyond the clinically visible margin&#44; determining sometimes equivocal and&#47;or unaesthetic margins in the surgical approach&#46; Moreover&#44; the recurrence rate described in the literature&#44; according to the method used for lesion excision and the time of post-treatment follow-up&#44; can reach 50&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Imiquimod &#40;IQ&#41; is an imidazoquinoline that acts on atypical melanocytes present in the epidermis&#44; inducing an immune response through cytokine secretion and cell response against these tumor cells&#44; which has been studied as a less invasive therapeutic option in the treatment of LM&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The topical use of Imiquimod 5&#37;&#44; applied six times a week for ten to 12 weeks&#44; with a time of drug action of eight hours at the lesion site&#44; results in clinical resolution in 78&#37; of cases and histopathological resolution in 76&#37;&#44; with an average recurrence rate of 24&#46;5&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Aiming to increase the diagnostic accuracy and therapeutic control of LM&#44; especially after less invasive alternative therapies&#44; the use of laser reflectance confocal microscopy &#40;RCM&#41; is a non-invasive exam that allows the <span class="elsevierStyleItalic">in vivo</span> observation of skin structures and cells&#44; with a similar resolution to that of histology&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">RCM is reported to present an 85&#37; sensitivity and 76&#37; specificity for the diagnosis of LM&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The increased number of atypical melanocytes at the dermal-epidermal junction&#44; the presence of pagetoid cells and&#47;or atypical cells in the epidermis&#44; perifollicular dendritic cells&#44; and nucleated cells in the dermal papilla are microscopic diagnostic criteria of ML on RCM&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">These data stimulated the development of a descriptive observational study aiming at diagnosing&#44; verifying the therapeutic result&#44; and the early detection of possible recurrence through RCM of cases of LM&#44; treated with topical Imiquimod 5&#37; from March 2019 to July 2020&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with a diagnosis of lentigo maligno confirmed by histopathological examination underwent 12 weeks of treatment with Imiquimod 5&#37; cream with daily application&#44; 6 times a week&#44; with a time of drug action of eight hours&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Clinical and dermoscopic images of the lesions were obtained using an iPhone 10 coupled to Dermlite&#174;&#59; and RCM images were obtained with the aid of Vivascope 1500&#174;&#44; before&#44; during&#44; and 60 days after the end of the therapy&#46; Cross-sectional 5&#8239;&#215;&#8239;5&#8239;mm images of the stratum corneum&#44; stratum granulosum&#44; stratum spinosum&#44; and superficial dermis were analyzed by two dermatologists with experience in performing this technique&#46; Additionally&#44; the RCM will be repeated every three months in the first year of follow-up for early diagnosis of possible recurrence&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Six patients with an anatomopathological diagnosis of lentigo maligno were selected for the study&#46; The patients were phototypes II to III according to the Fitzpatrick classification&#44; with a history of previous intense sun exposure and a mean age of 75 years&#46; The regions affected by the lesions were the face in three cases &#40;50&#37;&#41;&#44; the back in one case &#40;16&#46;7&#37;&#41;&#44; and the scalp in two cases &#40;33&#46;3&#37;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Dermatological examination showed irregular brownish lesions in photo exposed areas with intense sun damage&#44; and dermoscopy showed an atypical pseudo network &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; RCM showed the presence of atypical pagetoid cells in the epidermis and atypical perifollicular dendritic cells&#44; with a loss of the epidermal structure &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Of the six selected patients&#44; five completed 12 weeks of treatment with IQ 5&#37;&#44; and one patient was lost to follow-up at eight weeks of treatment&#46; After 60 days of the end of treatment with IQ 5&#37;&#44; four patients underwent RCM&#44; and one patient is scheduled to undergo post-treatment RCM&#46; At the post-treatment dermatological examination&#44; evidence of clinical and dermoscopic healing of the lesions was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; whereas RCM examination showed the absence of pagetoid and&#47;or atypical cells in the epidermis&#44; absence of perifollicular dendritic cells and a preserved epidermis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">One of the patients&#44; before participating in the study&#44; had undergone three sessions of cryotherapy for the treatment of LM on the scalp&#44; with clinical and dermoscopic resolution of the lesion&#46; Four months after the last cryotherapy session&#44; there was a recurrence of the lesion&#44; diagnosed through RCM&#44; with the appearance of atypical perifollicular dendritic cells in clinically and dermoscopically healed areas&#46; The patient was then submitted to treatment with Imiquimod for 12 weeks&#44; and the post-treatment RCM was performed&#44; showing resolution of the condition&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The present study demonstrated that RCM allowed the early identification of recurrence of LM clinically and dermoscopically healed&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The present study is a work in progress&#44; with preliminary data suggesting the use of RCM as a tool in the therapeutic control and follow-up of lentigo maligno treated with Imiquimod&#46; LM affects mainly the elderly&#44; presenting as extensive lesions of difficult clinical delimitation in areas such as the face and neck&#44; which can result in difficulties regarding the surgical approach&#44; with aesthetic damage to the patient&#46; As it is an <span class="elsevierStyleItalic">in situ</span> lesion&#44; it allows the use of less invasive treatments&#44; and RCM has shown to be an extremely useful and practical tool in the therapeutic control and early diagnosis of possible recurrence&#46; Better conclusions will be attained with longer follow-up periods and the inclusion of more cases&#46; This prior communication is also an invitation to other authors to make similar observations&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0085" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0090" class="elsevierStylePara elsevierViewall">Priscila Ishioka&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Lilian Lemos Costa&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; design and planning of the study&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Marcus Maia&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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            0 => array:3 [
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              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lentigo maligna on the face&#58; a challenging conduct"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;S&#46; Gomes"
                            1 => "IFGP Barroso"
                            2 => "T&#46;B&#46;S&#46; Dutra"
                            3 => "D&#46;L&#46; Obadia"
                            4 => "T&#46;S&#46; Fracaroli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Bras Oftalm"
                        "fecha" => "2017"
                        "volumen" => "76"
                        "paginaInicial" => "161"
                        "paginaFinal" => "164"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma on chronically sun-damaged skin&#58; lentigo maligna and desmoplastic melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;E&#46; DeWane"
                            1 => "A&#46; Kelsey"
                            2 => "M&#46; Oliviero"
                            3 => "H&#46; Rabinovitz"
                            4 => "J&#46;M&#46; Grant-Kels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.03.066"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2019"
                        "volumen" => "81"
                        "paginaInicial" => "823"
                        "paginaFinal" => "833"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30930085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Confocal microscopy and lentigo maligna&#58; an in vivo pilot study for the assessment of response to imiquimod therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "FL Brand"
                            1 => "SMS Jafari"
                            2 => "RE Hunger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000495034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2019"
                        "volumen" => "235"
                        "paginaInicial" => "150"
                        "paginaFinal" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30554198"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lentigo maligna&#58; diagnosis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;W&#46; Bosbous"
                            1 => "W&#46;W&#46; Dzwierzynski"
                            2 => "M&#46; Neuburg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cps.2009.08.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Plast Surg"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "35"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19914456"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lentigo maligna-challenges&#44; observations&#44; imiquimod&#44; confocal microscopy&#44; and personalized treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "SW Fosko"
                            1 => "CP Navarrete-Dechent"
                            2 => "KS Nehal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2018.0531"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2018"
                        "volumen" => "154"
                        "paginaInicial" => "879"
                        "paginaFinal" => "881"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29847677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma&#58; need for standardization of treatment schedule and outcome measures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46; Tio"
                            1 => "J&#46; Woude"
                            2 => "C&#46;A&#46;C&#46; Prinsen"
                            3 => "E&#46;P&#46; Jansma"
                            4 => "R&#46; Hoekzema"
                            5 => "C&#46; Montfrans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.14085"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2017"
                        "volumen" => "31"
                        "paginaInicial" => "616"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27987308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term outcomes of imiquimod-treated lentigo maligna"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M Papanikolaou"
                            1 => "CM Lawrence"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.13896"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2019"
                        "volumen" => "44"
                        "paginaInicial" => "631"
                        "paginaFinal" => "636"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30663131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of non-surgical treatments for lentigo maligna"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Read"
                            1 => "C&#46; Noonan"
                            2 => "M&#46; David"
                            3 => "M&#46; Wagels"
                            4 => "M&#46; Foote"
                            5 => "H&#46; Schaider"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13252"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2016"
                        "volumen" => "30"
                        "paginaInicial" => "748"
                        "paginaFinal" => "753"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26299846"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of dermoscopy and reflectance confocal microscopy on the histopathologic diagnosis of lentigo maligna&#47;lentigo maligna melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Mataca"
                            1 => "M&#46; Migaldi"
                            2 => "A&#46;M&#46; Cesinaro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0000000000001212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2018"
                        "volumen" => "40"
                        "paginaInicial" => "884"
                        "paginaFinal" => "889"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29933314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Guitera"
                            1 => "G&#46; Pellacani"
                            2 => "K&#46;A&#46; Crotty"
                            3 => "R&#46;A&#46; Scolyer"
                            4 => "L&#46;X&#46; Li"
                            5 => "S&#46; Bassoli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2010.84"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2010"
                        "volumen" => "130"
                        "paginaInicial" => "2080"
                        "paginaFinal" => "2091"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20393481"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
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Research Letter
Practical application of laser reflectance confocal microscopy in the follow-up of patients with lentigo maligna undergoing treatment with Imiquimod
Priscila Ishiokaa,
Autor para correspondência
pishioka@uol.com.br

Corresponding author.
, Lilian Lemos Costab, Marcus Maiaa
a Dermatology Oncology Outpatient Clinic, Department of Internal Medicine, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil
b Dermatology Discipline, Department of Internal Medicine, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil
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with the presence of a high number of atypical melanocytes in the basal layer of the epidermis and peri-adnexal extension associated with solar elastosis and epidermal thinning&#44; due to the intense solar damage of the areas where these lesions originate&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">One of the difficulties in the treatment of LM is to define the true clinical and histopathological lesion extension&#44; as they present extended areas&#44; that is&#44; they can extend beyond the clinically visible margin&#44; determining sometimes equivocal and&#47;or unaesthetic margins in the surgical approach&#46; Moreover&#44; the recurrence rate described in the literature&#44; according to the method used for lesion excision and the time of post-treatment follow-up&#44; can reach 50&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Imiquimod &#40;IQ&#41; is an imidazoquinoline that acts on atypical melanocytes present in the epidermis&#44; inducing an immune response through cytokine secretion and cell response against these tumor cells&#44; which has been studied as a less invasive therapeutic option in the treatment of LM&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The topical use of Imiquimod 5&#37;&#44; applied six times a week for ten to 12 weeks&#44; with a time of drug action of eight hours at the lesion site&#44; results in clinical resolution in 78&#37; of cases and histopathological resolution in 76&#37;&#44; with an average recurrence rate of 24&#46;5&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Aiming to increase the diagnostic accuracy and therapeutic control of LM&#44; especially after less invasive alternative therapies&#44; the use of laser reflectance confocal microscopy &#40;RCM&#41; is a non-invasive exam that allows the <span class="elsevierStyleItalic">in vivo</span> observation of skin structures and cells&#44; with a similar resolution to that of histology&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">RCM is reported to present an 85&#37; sensitivity and 76&#37; specificity for the diagnosis of LM&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The increased number of atypical melanocytes at the dermal-epidermal junction&#44; the presence of pagetoid cells and&#47;or atypical cells in the epidermis&#44; perifollicular dendritic cells&#44; and nucleated cells in the dermal papilla are microscopic diagnostic criteria of ML on RCM&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">These data stimulated the development of a descriptive observational study aiming at diagnosing&#44; verifying the therapeutic result&#44; and the early detection of possible recurrence through RCM of cases of LM&#44; treated with topical Imiquimod 5&#37; from March 2019 to July 2020&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with a diagnosis of lentigo maligno confirmed by histopathological examination underwent 12 weeks of treatment with Imiquimod 5&#37; cream with daily application&#44; 6 times a week&#44; with a time of drug action of eight hours&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Clinical and dermoscopic images of the lesions were obtained using an iPhone 10 coupled to Dermlite&#174;&#59; and RCM images were obtained with the aid of Vivascope 1500&#174;&#44; before&#44; during&#44; and 60 days after the end of the therapy&#46; Cross-sectional 5&#8239;&#215;&#8239;5&#8239;mm images of the stratum corneum&#44; stratum granulosum&#44; stratum spinosum&#44; and superficial dermis were analyzed by two dermatologists with experience in performing this technique&#46; Additionally&#44; the RCM will be repeated every three months in the first year of follow-up for early diagnosis of possible recurrence&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Six patients with an anatomopathological diagnosis of lentigo maligno were selected for the study&#46; The patients were phototypes II to III according to the Fitzpatrick classification&#44; with a history of previous intense sun exposure and a mean age of 75 years&#46; The regions affected by the lesions were the face in three cases &#40;50&#37;&#41;&#44; the back in one case &#40;16&#46;7&#37;&#41;&#44; and the scalp in two cases &#40;33&#46;3&#37;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Dermatological examination showed irregular brownish lesions in photo exposed areas with intense sun damage&#44; and dermoscopy showed an atypical pseudo network &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; RCM showed the presence of atypical pagetoid cells in the epidermis and atypical perifollicular dendritic cells&#44; with a loss of the epidermal structure &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Of the six selected patients&#44; five completed 12 weeks of treatment with IQ 5&#37;&#44; and one patient was lost to follow-up at eight weeks of treatment&#46; After 60 days of the end of treatment with IQ 5&#37;&#44; four patients underwent RCM&#44; and one patient is scheduled to undergo post-treatment RCM&#46; At the post-treatment dermatological examination&#44; evidence of clinical and dermoscopic healing of the lesions was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; whereas RCM examination showed the absence of pagetoid and&#47;or atypical cells in the epidermis&#44; absence of perifollicular dendritic cells and a preserved epidermis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">One of the patients&#44; before participating in the study&#44; had undergone three sessions of cryotherapy for the treatment of LM on the scalp&#44; with clinical and dermoscopic resolution of the lesion&#46; Four months after the last cryotherapy session&#44; there was a recurrence of the lesion&#44; diagnosed through RCM&#44; with the appearance of atypical perifollicular dendritic cells in clinically and dermoscopically healed areas&#46; The patient was then submitted to treatment with Imiquimod for 12 weeks&#44; and the post-treatment RCM was performed&#44; showing resolution of the condition&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The present study demonstrated that RCM allowed the early identification of recurrence of LM clinically and dermoscopically healed&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The present study is a work in progress&#44; with preliminary data suggesting the use of RCM as a tool in the therapeutic control and follow-up of lentigo maligno treated with Imiquimod&#46; LM affects mainly the elderly&#44; presenting as extensive lesions of difficult clinical delimitation in areas such as the face and neck&#44; which can result in difficulties regarding the surgical approach&#44; with aesthetic damage to the patient&#46; As it is an <span class="elsevierStyleItalic">in situ</span> lesion&#44; it allows the use of less invasive treatments&#44; and RCM has shown to be an extremely useful and practical tool in the therapeutic control and early diagnosis of possible recurrence&#46; Better conclusions will be attained with longer follow-up periods and the inclusion of more cases&#46; This prior communication is also an invitation to other authors to make similar observations&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0085" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0090" class="elsevierStylePara elsevierViewall">Priscila Ishioka&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Lilian Lemos Costa&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; design and planning of the study&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Marcus Maia&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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      "seccion" => array:1 [
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          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lentigo maligna on the face&#58; a challenging conduct"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;S&#46; Gomes"
                            1 => "IFGP Barroso"
                            2 => "T&#46;B&#46;S&#46; Dutra"
                            3 => "D&#46;L&#46; Obadia"
                            4 => "T&#46;S&#46; Fracaroli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Bras Oftalm"
                        "fecha" => "2017"
                        "volumen" => "76"
                        "paginaInicial" => "161"
                        "paginaFinal" => "164"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma on chronically sun-damaged skin&#58; lentigo maligna and desmoplastic melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;E&#46; DeWane"
                            1 => "A&#46; Kelsey"
                            2 => "M&#46; Oliviero"
                            3 => "H&#46; Rabinovitz"
                            4 => "J&#46;M&#46; Grant-Kels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.03.066"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2019"
                        "volumen" => "81"
                        "paginaInicial" => "823"
                        "paginaFinal" => "833"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30930085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Confocal microscopy and lentigo maligna&#58; an in vivo pilot study for the assessment of response to imiquimod therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "FL Brand"
                            1 => "SMS Jafari"
                            2 => "RE Hunger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000495034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2019"
                        "volumen" => "235"
                        "paginaInicial" => "150"
                        "paginaFinal" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30554198"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lentigo maligna&#58; diagnosis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;W&#46; Bosbous"
                            1 => "W&#46;W&#46; Dzwierzynski"
                            2 => "M&#46; Neuburg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cps.2009.08.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Plast Surg"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "35"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19914456"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lentigo maligna-challenges&#44; observations&#44; imiquimod&#44; confocal microscopy&#44; and personalized treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "SW Fosko"
                            1 => "CP Navarrete-Dechent"
                            2 => "KS Nehal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2018.0531"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2018"
                        "volumen" => "154"
                        "paginaInicial" => "879"
                        "paginaFinal" => "881"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29847677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma&#58; need for standardization of treatment schedule and outcome measures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46; Tio"
                            1 => "J&#46; Woude"
                            2 => "C&#46;A&#46;C&#46; Prinsen"
                            3 => "E&#46;P&#46; Jansma"
                            4 => "R&#46; Hoekzema"
                            5 => "C&#46; Montfrans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.14085"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2017"
                        "volumen" => "31"
                        "paginaInicial" => "616"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27987308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term outcomes of imiquimod-treated lentigo maligna"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M Papanikolaou"
                            1 => "CM Lawrence"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.13896"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2019"
                        "volumen" => "44"
                        "paginaInicial" => "631"
                        "paginaFinal" => "636"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30663131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of non-surgical treatments for lentigo maligna"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Read"
                            1 => "C&#46; Noonan"
                            2 => "M&#46; David"
                            3 => "M&#46; Wagels"
                            4 => "M&#46; Foote"
                            5 => "H&#46; Schaider"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13252"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2016"
                        "volumen" => "30"
                        "paginaInicial" => "748"
                        "paginaFinal" => "753"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26299846"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of dermoscopy and reflectance confocal microscopy on the histopathologic diagnosis of lentigo maligna&#47;lentigo maligna melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Mataca"
                            1 => "M&#46; Migaldi"
                            2 => "A&#46;M&#46; Cesinaro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0000000000001212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2018"
                        "volumen" => "40"
                        "paginaInicial" => "884"
                        "paginaFinal" => "889"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29933314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "G&#46; Pellacani"
                            2 => "K&#46;A&#46; Crotty"
                            3 => "R&#46;A&#46; Scolyer"
                            4 => "L&#46;X&#46; Li"
                            5 => "S&#46; Bassoli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2010.84"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2010"
                        "volumen" => "130"
                        "paginaInicial" => "2080"
                        "paginaFinal" => "2091"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20393481"
                            "web" => "Medline"
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                      ]
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            ]
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To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.