que se leu este artigo
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(B), Um aumento maior mostrou vários neutrófilos infiltrados (Hematoxilina & eosina, 400×). 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Tumor measuring 5 cm, rounded, with an erythematous-violaceous color, located on the right preauricular region, with friable and necrotic areas. 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array:2 [ "entidad" => "Department of Dermatology, Fukushima Medical University, Fukushima, Japan" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1090 "Ancho" => 1156 "Tamanyo" => 260012 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A), Histological features showing dense neutrophilic infiltration throughout the edematous dermis (Hematoxylin & eosin, original magnification ×40). (B), Higher magnification showing the large number of infiltrating neutrophils (Hematoxylin & eosin, ×400). (C), Histological examination showing a septal panniculitis in the subcutaneous nodule in the lower extremity (Hematoxylin & eosin, ×20).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 54-year-old female was admitted to our department, complaining of a 4-day history of up to 40.3 °C fever and cutaneous eruptions on the neck. The patient had been suffering from myelodysplastic syndrome (MDS), for which no drugs, including granulocyte-colony stimulating factor (G-CSF), were administered. Physical examination showed numerous concrescences of blisters clearly localized in the V-neck area (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a, b). Painful erythematous nodules were scattered on the cheeks, but the tip of the nose was spared. Furthermore, there was one blister on the right forearm as well as painful erythematous nodules on the upper and lower extremities. She did not have any mucosal lesions or a prior history of recurrent oral aphthae. Laboratory examination showed a white blood cell count of 8,100/μL with 3% Band, 21% Seg, 9% Lym, 7% Mono, and 57% Blast, decreased levels of hemoglobin (8.6 g/dL) and platelets (108,000/μL), and increased levels of C-reactive protein (26.02 mg/dL). Blood culture was sterile. A biopsy specimen from the peripheral edge of the bulla on the neck showed a subepidermal bulla and dense neutrophilic infiltration in the upper to mid-dermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>a, b). Immature myeloid cell infiltration was not detected. Infiltration of histiocytes/histiocytoid cells was not observed, and immunohistological examination showed scattered CD68- and MPO-positive cells which were not prominent. Additionally, another biopsy taken from the lower leg showed infiltration of inflammatory cells, mainly lymphocytes, around the vessels in the septa of the subcutaneous fat tissue (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>c). Hematological examination and bone marrow biopsy revealed transformation from MDS into acute myelocytic leukemia, and chemotherapy including prednisolone was immediately started in the hematology department. After about one week, all of the bullous lesions were re-epithelialized.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The present case developed a sudden onset of skin lesions, which histopathologically showed a predominant neutrophilic infiltration without leukocytoclastic vasculitis. In addition, fever, elevated C-reactive protein, and rapid response to systemic steroids were observed. White blood cell count was within the upper limit of the normal range but two times higher than the usual value. Thus, the patient fulfilled the criteria for Sweet syndrome (SS). Cutaneous lesions of SS associated with myelodysplasia tend to be vesicular, bullous, or erosive. The present case developed bullous SS, simultaneously with the blastic crisis of MDS. Of interest, the lesions showed a peculiar distribution of well-circumscribed erythema in the V-neck area not protected by clothes during the season when the dose of ultraviolet radiation is increased in Japan, which was considered to be a photo-Koebner phenomenon. Only several cases of photo-induced or photo-distributed SS have been reported, in which both ultraviolet A and ultraviolet B were candidates for induction of skin lesions.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> Although phototesting was not performed in the present case, the patient had no previous history of photosensitive dermatitis or of taking drugs that can induce photosensitive eruptions. To our knowledge, the current report is the first case of photolocalized bullous SS. The direct action of ultraviolet is speculated to activate and recruit neutrophils via interleukin-8, tumor necrosis factor-α, E-selectin, interleukin-1α, and G-CSF<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> as well as ultraviolet-induced local immunosuppression. Finally, the patient concurrently developed infiltrative erythematous nodules on the face and extremities. Biopsy showed septal panniculitis with lymphocytic infiltration without neutrophil infiltration in either dermis or subcutis; however, all of the concurrent lesions were considered to be part of the same spectrum.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0015" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors' contributions</span><p id="par0020" class="elsevierStylePara elsevierViewall">Mai Endo: Designed the study; performed the research and contributed to analysis and interpretation of data; wrote the initial draft of the manuscript; read and approved the final version of the manuscript.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Miyuki Yamamoto: Performed the research and contributed to analysis and interpretation of data; read and approved the final version of the manuscript.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Mikio Ohtsuka: Performed the research and contributed to analysis and interpretation of data; read and approved the final version of the manuscript.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Toshiyuki Yamamoto: Designed the study; assisted in the preparation of the manuscript; read and approved the final version of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors' contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-08-20" "fechaAceptado" => "2020-10-12" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Department of Dermatology, Fukushima Medical University School of Medicine.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 562 "Ancho" => 1155 "Tamanyo" => 75912 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A), Well-circumscribed, painful, infiltrative erythema with tense blisters in the V-neck area. (B), Close-up view.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1090 "Ancho" => 1156 "Tamanyo" => 260012 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A), Histological features showing dense neutrophilic infiltration throughout the edematous dermis (Hematoxylin & eosin, original magnification ×40). (B), Higher magnification showing the large number of infiltrating neutrophils (Hematoxylin & eosin, ×400). (C), Histological examination showing a septal panniculitis in the subcutaneous nodule in the lower extremity (Hematoxylin & eosin, ×20).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photoaggravation of acute febrile neutrophilic dermatosis Sweet’s syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Horio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1346-8138.1985.tb01558.x" "Revista" => array:6 [ "tituloSerie" => "J Dermatol." 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Ano/Mês | Html | Total | |
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2024 Novembro | 13 | 10 | 23 |
2024 Outubro | 103 | 69 | 172 |
2024 Setembro | 131 | 79 | 210 |
2024 Agosto | 129 | 111 | 240 |
2024 Julho | 140 | 111 | 251 |
2024 Junho | 132 | 75 | 207 |
2024 Maio | 95 | 67 | 162 |
2024 Abril | 104 | 96 | 200 |
2024 Março | 83 | 65 | 148 |
2024 Fevereiro | 100 | 90 | 190 |
2024 Janeiro | 69 | 62 | 131 |
2023 Dezembro | 66 | 62 | 128 |
2023 Novembro | 80 | 91 | 171 |
2023 Outubro | 73 | 96 | 169 |
2023 Setembro | 110 | 90 | 200 |
2023 Agosto | 62 | 33 | 95 |
2023 Julho | 69 | 47 | 116 |
2023 Junho | 64 | 52 | 116 |
2023 Maio | 45 | 20 | 65 |
2023 Abril | 43 | 17 | 60 |
2023 Março | 50 | 46 | 96 |
2023 Fevereiro | 36 | 35 | 71 |
2023 Janeiro | 57 | 40 | 97 |
2022 Dezembro | 60 | 29 | 89 |
2022 Novembro | 70 | 50 | 120 |
2022 Outubro | 83 | 53 | 136 |
2022 Setembro | 58 | 84 | 142 |
2022 Agosto | 40 | 47 | 87 |
2022 Julho | 58 | 66 | 124 |
2022 Junho | 72 | 103 | 175 |
2022 Maio | 111 | 74 | 185 |
2022 Abril | 96 | 87 | 183 |
2022 Março | 159 | 99 | 258 |
2022 Fevereiro | 42 | 35 | 77 |