Case Report
Basaloid follicular hamartoma associated with follicular mucinosis and inflammation
Solange Edelman
, Adriana Natalia Torres Huamani, María Del Valle Centeno, Andrea Bettina Cervini
Autor para correspondência
Servicio de Dermatología, Hospital Nacional de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
Lido
5519
Vezesque se leu este artigo
2513
Total PDF
3006
Total HTML
Compartilhar estatÃsticas
array:24 [ "pii" => "S0365059621002543" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.10.012" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "462" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275221002599" "issn" => "26662752" "doi" => "10.1016/j.abdp.2021.11.003" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "462" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso Clínico</span>" "titulo" => "Hamartoma folicular basaloide associado a mucinose folicular e inflamação" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "45" "paginaFinal" => "48" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 507 "Ancho" => 900 "Tamanyo" => 59279 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesão de cor laranja‐rosada com formação de escamas, especialmente perifolicular, sem padrão de lesão melanocítica ou vascular.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Solange Edelman, Adriana Natalia Torres Huamani, María Del Valle Centeno, Andrea Bettina Cervini" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Solange" "apellidos" => "Edelman" ] 1 => array:2 [ "nombre" => "Adriana Natalia" "apellidos" => "Torres Huamani" ] 2 => array:2 [ "nombre" => "María Del Valle" "apellidos" => "Centeno" ] 3 => array:2 [ "nombre" => "Andrea Bettina" "apellidos" => "Cervini" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059621002543" "doi" => "10.1016/j.abd.2020.10.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621002543?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221002599?idApp=UINPBA00008Z" "url" => "/26662752/0000009700000001/v1_202202030913/S2666275221002599/v1_202202030913/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059621002579" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.08.032" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "465" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Chronic recalcitrant erythema nodosum leprosum: therapeutic dilemma and role of <span class="elsevierStyleItalic">mycobacterium indicus pranii</span> vaccine" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "49" "paginaFinal" => "53" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1546 "Ancho" => 2174 "Tamanyo" => 487304 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lepromatous Leprosy with ENL showing lesions before vaccination.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sunil Kumar Gupta, Sushantika Kumari" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Sunil Kumar" "apellidos" => "Gupta" ] 1 => array:2 [ "nombre" => "Sushantika" "apellidos" => "Kumari" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221002629" "doi" => "10.1016/j.abdp.2021.11.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221002629?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621002579?idApp=UINPBA00008Z" "url" => "/03650596/0000009700000001/v1_202201230559/S0365059621002579/v1_202201230559/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059621002580" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.05.009" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "466" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Infantile hemangiomas: risk factors for complications, recurrence and unaesthetic sequelae" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "37" "paginaFinal" => "44" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 952 "Ancho" => 3340 "Tamanyo" => 196716 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Post-hoc</span> comparisons using generalized estimating equation (GEE) modeling related to propranolol treatment time, described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. (A), PHACES; (B), Segmental hemangiomas and (C), Ulcerated hemangiomas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Letícia Gaertner Mariani, Lílian Moraes Ferreira, Diego Luiz Rovaris, Renan Rangel Bonamigo, Ana Elisa Kiszewski" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Letícia Gaertner" "apellidos" => "Mariani" ] 1 => array:2 [ "nombre" => "Lílian Moraes" "apellidos" => "Ferreira" ] 2 => array:2 [ "nombre" => "Diego Luiz" "apellidos" => "Rovaris" ] 3 => array:2 [ "nombre" => "Renan Rangel" "apellidos" => "Bonamigo" ] 4 => array:2 [ "nombre" => "Ana Elisa" "apellidos" => "Kiszewski" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221002630" "doi" => "10.1016/j.abdp.2021.11.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221002630?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621002580?idApp=UINPBA00008Z" "url" => "/03650596/0000009700000001/v1_202201230559/S0365059621002580/v1_202201230559/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Basaloid follicular hamartoma associated with follicular mucinosis and inflammation" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "45" "paginaFinal" => "48" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Solange Edelman, Adriana Natalia Torres Huamani, María Del Valle Centeno, Andrea Bettina Cervini" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Solange" "apellidos" => "Edelman" "email" => array:1 [ 0 => "solangeedelman@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Adriana Natalia" "apellidos" => "Torres Huamani" ] 2 => array:2 [ "nombre" => "María Del Valle" "apellidos" => "Centeno" ] 3 => array:2 [ "nombre" => "Andrea Bettina" "apellidos" => "Cervini" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Nacional de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1259 "Ancho" => 1674 "Tamanyo" => 444217 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Bcl-2 positive only in the outermost tumor cells; (IMQ, 100×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Basaloid follicular hamartoma(BFH) is a benign lesion that should be carefully evaluated because the entity may be mistaken both clinically and histologically for basal cell carcinoma. The formation of BFH has been linked to a mutation in the Patched (PTCH-1) gene, which is part of the same pathway involved in Gorlin-Goltz syndrome.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Due to the varied clinical presentation of BFH, it is imperative to perform a skin biopsy to distinguish BFH from other common skin lesions.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Currently, there are no standard treatments for BFH.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Correct identification allows for periodic monitoring for malignant transformation while sparing patients unnecessary surgery.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 9-year-old boy was consulted for an asymptomatic congenital lesion located on the forehead increasing in size over the years. The child was born with a cleft lip and palate which was surgically corrected. There was no family history of relevance related to this dermatosis.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Physical examination showed two plantar pits and a rounded reddish plaque with warty areas in the central region of the forehead (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Dermoscopy revealed a reddish scaly lesion suggesting increased keratinization, mainly at the perifollicular level, without a distinctive melanocytic or vascular pattern (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Based on the diagnostic suspicion of nevus sebaceous of Jadassohn or linear verrucous epidermal nevus, a biopsy was performed.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Histological examination with hematoxylin and eosin staining showed in the dermis a basaloid proliferation of basaloid cells with anastomosing cords developed from a hair follicle or lobulated nests with occasional formation of horn cysts arranged among the pilosebaceous units and fibrous stroma. Predominantly mononuclear dense inflammatory infiltrates were seen (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The cells of the lobulated nests were separated by Alcian-blue-positive intercellular material possibly corresponding to mucin deposits (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). Special stains Bcl-2 demonstrated weak cytoplasmic positivity in the outermost tumor cells only (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>) and CD-34 was positive in stromal cells next to tumor cells (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The lesion was surgically removed. Abdominal ultrasound, as well as panoramic maxillary and anterolateral skull XRays, were performed to rule out Gorlin-Goltz syndrome.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">BFH is a rare, benign, superficial malformation of hair follicles that histologically presents as an epithelial proliferation of basaloid cells and clinically in various forms, with and without associated diseases.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Genetic studies have linked BFH to a mutation in the PTCH-1 gene on chromosomal band 9q23. The gene is part of the same pathway involved in Gorlin-Goltz syndrome, though its expression is less severe.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The PTCH-1 gene encodes a receptor for the protein product of the Sonic Hedgehog gene (SHH). The mutation of the gene determines its loss of function. The PTCH-1 receptor forms a receptor complex with another transmembrane protein known as SMO (for “smoothened”). When the SHH protein is absent, the PTCH-1 receptor inactivates SMO and keeps it from transducing a downstream signal. The binding of the SHH protein to the PTCH-1 receptor releases the suppression of SMO, causing the upregulation of hedgehog target genes through a signal cascade that involves transcription factors in the Gli family. Unregulated signaling can lead to increased cell division resulting in abnormal growth and abnormal patterning.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">BFH may be congenital or acquired.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The clinical presentation is diverse in the form of skin-colored-to-brown papules, nodules, or plaques on the face, scalp, and occasionally, the trunk.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Five different forms have been described: 1- solitary or multiple papules, 2- localized linear or unilateral plaque, that may be distributed along the Blaschko lines, 3- a localized plaque with alopecia, 4- generalized dominantly inherited familial type without the associated disorder, or 5- generalized papules associated with diffuse alopecia and myasthenia gravis, systemic lupus erythematosus, or cystic fibrosis.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5–7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">BFH may present alone or in association with other hereditary skin diseases, such as Bazex-Dupre-Christol syndrome, Brown-Crounse syndrome, and Happle-Tinschert syndrome.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,7</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Despite variable clinical manifestations, all types of BFH present with the same histopathological features, mainly including multifocal islands and branching cords of basaloid epithelial cells in the papillary dermis, some of which are connected to the epidermis and dilated hair follicles. The formation of keratin cysts is common within the branching cords or lace-like networks of basaloid cells. Neither cellular atypia nor mitotic figures are seen in BFH. Immunohistochemistry is positive for CD-34 in the stroma and for Bcl-2 in the periphery of the trabeculae. The Ki67 index is low.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,6–8</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">The primary entity to consider in the differential diagnosis’s basal cell carcinoma (BCC), mainly the infundibulocystic subtype.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4,7</span></a> Clinically, other differential diagnoses of localized form are: adnexal tumors, nevi, trichoepithelioma, syringocystoadenoma, intradermal melanocytic nevus, seborrheic keratosis, sebaceous nevus, syringoma, angiofibroma. BFH is a linear distribution may mimic linear epidermal nevus, striated lichen, and linear morphea. Generalized BFH may represent generalized follicular hamartoma syndrome, tuberous sclerosis, Cowden syndrome, multiple trichoepitheliomas, Gorlin-Goltz syndrome, and Rombo syndrome. The main histologic differential diagnosis includes infundibulocystic BCC, folliculocentric basaloid proliferation, and trichoepithelioma.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,6,7,9</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">BFH should be closely monitored as they may evolve into BCC.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Different treatments, such as surgery, carbon dioxide laser, and photodynamic therapy have been proposed.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Here, the authors present a rare condition with an unusual clinical and histopathological presentation that may correspond to a clinical manifestation of a mutation of the PTCH gene. To the authors’ knowledge, up to now no other cases of BFH with mucinosis and inflammation have been published in the literature.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0100" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors’ contributions</span><p id="par0105" class="elsevierStylePara elsevierViewall">Solange Edelman: Drafting and editing of the manuscript; critical review of the literature; critical review of the manuscript.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Adriana Natalia Torres Huamani: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.</p><p id="par0115" class="elsevierStylePara elsevierViewall">Adriana Natalia Torres Huamani: Approval of the final version of the manuscript; collection, analysis, and interpretation of data.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Andrea Bettina Cervini: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0125" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1653835" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1470067" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Financial support" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Authors’ contributions" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 8 => array:2 [ "identificador" => "xack583112" "titulo" => "Acknowledgment" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-09-13" "fechaAceptado" => "2020-10-07" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1470067" "palabras" => array:3 [ 0 => "Carcinoma, basal cell" 1 => "Genes, tumor suppressor" 2 => "Hamartoma" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Basaloid follicular hamartoma is a benign, superficial malformation of hair follicles that can be mistaken both clinical and histopathologically for basal cell carcinoma. Basaloid follicular hamartoma has been linked to a mutation in the PTCH-1 gene, which is part of the same pathway involved in Gorlin-Goltz syndrome. Here we present a 9-year-old patient with an asymptomatic congenital lesion on the forehead, which increased in size over the years. Histopathology showed a basaloid follicular hamartoma associated with follicular mucinosis and inflammation. Gorlin-Goltz syndrome was ruled out by clinical examination.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina.</p>" ] ] "multimedia" => array:6 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 946 "Ancho" => 1674 "Tamanyo" => 223292 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rounded reddish plaque with warty areas.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 945 "Ancho" => 1674 "Tamanyo" => 166229 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Pinkish-orange lesion with scale formation especially at the perifollicular level without a distinctive melanocytic or vascular pattern.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1260 "Ancho" => 1674 "Tamanyo" => 548757 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Predominantly mononuclear dense inflammatory infiltrates are seen (Hematoxylin & eosin, ×400).</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1259 "Ancho" => 1674 "Tamanyo" => 383987 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Alcian-blue-positive intercellular material possibly corresponding to mucin deposits. (Alcian blue, ×100).</p>" ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1259 "Ancho" => 1674 "Tamanyo" => 444217 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Bcl-2 positive only in the outermost tumor cells; (IMQ, 100×).</p>" ] ] 5 => array:8 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 2229 "Ancho" => 1674 "Tamanyo" => 523885 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">CD-34 positive in stromal tumor cells; (IMQ, 40×).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basaloid Follicular Hamartoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O. Mills" 1 => "L.B. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5858/2008-0620-RS.1" "Revista" => array:6 [ "tituloSerie" => "Arch Pathol Lab Med" "fecha" => "2010" "volumen" => "134" "paginaInicial" => "1215" "paginaFinal" => "1219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20670146" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hamartoma folicular basaloide linear unilateral con lesiones cutáneas y mucosas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.N. Cabrera" 1 => "P.D. Giovanna" 2 => "S. García" 3 => "K.V. Nadur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Argent" "fecha" => "2013" "volumen" => "19" "paginaInicial" => "100" "paginaFinal" => "105" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital Systematized Basaloid Follicular Hamartoma with Microphthalmia and Hemimegalencephaly" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Boccaletti" 1 => "P. Accorsi" 2 => "L. Pinelli" 3 => "M. Ungari" 4 => "L. Giordano" 5 => "I. Neri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1525-1470.2010.01225.x" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol" "fecha" => "2011" "volumen" => "28" "paginaInicial" => "555" "paginaFinal" => "560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21062348" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basaloid follicular hamartoma: clinical, dermoscopic, and histopathological characteristics of case" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Choi" 1 => "M. Liau" 2 => "J. Huang" 3 => "K.B. Tan" 4 => "D. Aw" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Online J" "fecha" => "2017" "volumen" => "23" "paginaInicial" => "13030" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29469801" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basaloid follicular hamartoma: a cautionary tale and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Saxena" 1 => "M. Shapiro" 2 => "D.A. Kasper" 3 => "J.E. Fitzpatrick" 4 => "J.R. Mellette Junior" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2007.33231.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2007" "volumen" => "33" "paginaInicial" => "1130" "paginaFinal" => "1135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17760608" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Linear Unilateral Basaloid Follicular Hamartoma Following Blaschko’s Lines: Two Case Reports and Review of the Literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.C.L. Jiménez" 1 => "C. Grau" 2 => "D.I. Norris" 3 => "T.M. Dámaso" 4 => "A. Azón" 5 => "L.B. Hernando" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr Dermatol" "fecha" => "2017" "volumen" => "34" "paginaInicial" => "196" "paginaFinal" => "200" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital localized basaloid follicular hamartoma: a case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "X.C. Yang" 1 => "H. Yan" 2 => "F. Hao" 3 => "Q.Y. Yie" 4 => "B.Y. Zhong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2010.04275.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2010" "volumen" => "49" "paginaInicial" => "443" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20465704" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital non-familial unilateral basaloid follicular hamartoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Harman" 1 => "H.S. Inalöz" 2 => "S. Akdeniz" 3 => "S.S. Inalöz" 4 => "A. Aslan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "1999" "volumen" => "13" "paginaInicial" => "210" "paginaFinal" => "213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10642058" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hamartoma folicular basaloide lineal unilateral/Lineal unilateral basaloid follicular hamartoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Ramos" 1 => "B. Diaz Martinez" 2 => "I. Estirado" 3 => "M. Alramadan" 4 => "I. Buedo" 5 => "A. Peña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Cutan Iber Lat Am" "fecha" => "2009" "volumen" => "37" "paginaInicial" => "251" "paginaFinal" => "253" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack583112" "titulo" => "Acknowledgment" "texto" => "<p id="par0130" class="elsevierStylePara elsevierViewall">Thanks to Dr Stefano Paola.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009700000001/v1_202201230559/S0365059621002543/v1_202201230559/en/main.assets" "Apartado" => array:4 [ "identificador" => "80638" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Report" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009700000001/v1_202201230559/S0365059621002543/v1_202201230559/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621002543?idApp=UINPBA00008Z" ]
| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 18 | 4 | 22 |
| 2024 Outubro | 138 | 84 | 222 |
| 2024 Setembro | 151 | 112 | 263 |
| 2024 Agosto | 180 | 139 | 319 |
| 2024 Julho | 161 | 133 | 294 |
| 2024 Junho | 139 | 81 | 220 |
| 2024 Maio | 112 | 67 | 179 |
| 2024 Abril | 132 | 84 | 216 |
| 2024 Março | 94 | 97 | 191 |
| 2024 Fevereiro | 113 | 119 | 232 |
| 2024 Janeiro | 70 | 94 | 164 |
| 2023 Dezembro | 51 | 86 | 137 |
| 2023 Novembro | 76 | 80 | 156 |
| 2023 Outubro | 80 | 69 | 149 |
| 2023 Setembro | 79 | 74 | 153 |
| 2023 Agosto | 58 | 36 | 94 |
| 2023 Julho | 62 | 48 | 110 |
| 2023 Junho | 65 | 51 | 116 |
| 2023 Maio | 46 | 31 | 77 |
| 2023 Abril | 34 | 20 | 54 |
| 2023 Março | 80 | 54 | 134 |
| 2023 Fevereiro | 53 | 40 | 93 |
| 2023 Janeiro | 59 | 49 | 108 |
| 2022 Dezembro | 65 | 34 | 99 |
| 2022 Novembro | 76 | 71 | 147 |
| 2022 Outubro | 100 | 50 | 150 |
| 2022 Setembro | 62 | 84 | 146 |
| 2022 Agosto | 67 | 48 | 115 |
| 2022 Julho | 48 | 55 | 103 |
| 2022 Junho | 64 | 69 | 133 |
| 2022 Maio | 42 | 47 | 89 |
| 2022 Abril | 65 | 49 | 114 |
| 2022 Março | 67 | 83 | 150 |
| 2022 Fevereiro | 111 | 72 | 183 |
| 2022 Janeiro | 133 | 108 | 241 |
| 2021 Dezembro | 39 | 68 | 107 |
| 2021 Novembro | 16 | 23 | 39 |
Mostrar tudo
