que se leu este artigo
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be solved" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "490" "paginaFinal" => "493" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gustavo de Sá Menezes Carvalho, Karina Baruel de Camargo Votto Calbucci, Rute Facchini Lellis, John Verrinder Veasey" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Gustavo de Sá Menezes" "apellidos" => "Carvalho" "email" => array:1 [ 0 => "gustavo.carvalho@msn.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Karina Baruel de Camargo Votto" "apellidos" => "Calbucci" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Rute Facchini" "apellidos" => "Lellis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "John Verrinder" "apellidos" => "Veasey" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Dermatology Clinic, Santa Casa de Misericórdia, São Paulo, SP, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Pathology Laboratory, Santa Casa de Misericórdia, São Paulo, SP, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 681 "Ancho" => 905 "Tamanyo" => 178912 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathological analysis of chromoblastomycosis (Hematoxylin & eosin, ×40). Continuous arrow: muriform body (MB) in the center of an intraepidermal microabscess, pathognomonic of the disease. Dashed arrows: identification of septated dematiaceous hyphae.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 58-year-old male patient, born in the state of Pará, reported a lesion on the right thigh region for 15 years, characterized by an erythematous plaque, with well-defined borders, a verrucous surface and some nodular areas that measured about 13 cm in its largest axis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The patient denied a history of local trauma. A direct microscopic examination was performed, which showed the presence of muriform cells or Medlar bodies (MB) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Additionally, fungal culture disclosed the growth of a blackish and velvety colony, with macro-microscopic morphology compatible with <span class="elsevierStyleItalic">Fonsecaea pedrosoi</span>. The anatomopathological examination showed MB, some associated with dematiaceous hyphae, which received the name of “Borelli's spiders” (BS). These findings confirmed the diagnosis of chromoblastomycosis (CBM), and then treatment with itraconazole (200 mg/day for six months) was started, with no significant improvement of the lesions; therefore, it was necessary to combine other therapies (cryotherapy and surgical excision).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">CBM is a type of mycosis with chronic evolution that affects the skin and subcutaneous tissue, caused by dematiaceous filamentous fungi.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Its main causative agents are <span class="elsevierStyleItalic">Fonsecaea pedrosoi</span> and <span class="elsevierStyleItalic">Phialophora verrucosa</span>, geophilic organisms with a high prevalence in humid areas of tropical and subtropical climates.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> The most frequently affected sites are the lower limbs due to a traumatic mechanism, through the inoculation of hyphae and fungal conidia into the host’s skin.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> Once installed in the tissue, the fungus adheres to the epithelial cells and differentiates into structures called muriform, fumagoid, or sclerotic cells, also known as Medlar bodies (MB), which resist destruction by the host's effector cells, favoring the progression of the infection. The cutaneous lesions are polymorphic, including nodules, plaques, tumors, and scars.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a> The diagnosis of CBM is confirmed by the detection of MB, pathognomonic of CBM, in direct mycological and histopathological examination, regardless of the species involved (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>).<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Reports of dematiaceous hyphae found in association with MB have been described for decades, primarily by Borelli. The morphological aspect that the fungal structures acquire was called BS, and its finding was initially associated with the more pathogenic species of this mycosis.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5–8</span></a> Subsequently, this finding was associated with the species that were more resistant to therapy, being indicative of low response to classic treatments, requiring associations, dose adjustments, or surgical approaches in many cases.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,6,7</span></a> These structures are evident in both direct mycological and histopathological examinations, as seen in the present case (<a class="elsevierStyleCrossRefs" href="#fig0020">Figs. 4 and 5</a>).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In studies on CBM immunology, it was observed that the fungi are able to regulate the host's inflammatory response, preventing the inflammatory process and contributing to the adaptation and opportunism process.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> MBs can alter the gene expression pattern of macrophages, resulting in the histopathological characteristics observed in CBM with granulomatous inflammatory infiltrates, sometimes suppurative and with the presence of micro-abscesses. The presence of hyphae and muriform cells in the tissues increases the levels of the inflammatory cytokines TNF-α (tumor necrosis factor-alpha), IL-1β (interleukin 1-beta), and IL-6 (interleukin-6), increasing disease duration and the pathogen persistence in the tissue.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This uncontrolled and chronic immune response does not provide protection for the host against the fungus and ends up leading to the maintenance of the infection.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> However, studies that correlate the pathophysiology related to BS and its immune response are still lacking in the literature.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The understanding of these findings becomes of the utmost importance for the treatment of CBM, which is considered a challenge, especially in the most exuberant and severe clinical forms.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> The treatment of CBM is associated with low cure rates and high chances of recurrence.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> Long periods of therapy with antifungals are required, which can be associated with surgery, cryotherapy, thermotherapy, and immunotherapy.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">These data lead us to understand that the parasite/host binomial balance is affected by interference on both sides, which may favor the emergence of BS and would possibly act to make the disease chronic and hinder therapy. With the advancement of the use of immunomodulatory drugs, the possibility of finding these structures increases. Future studies on the clinical presentations and laboratory, and therapeutic expressions in these cases may help to better understand the disease and its management.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Authors’ contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Gustavo de Sá Menezes Carvalho: Drafting and editing of the manuscript; collection, analysis, and interpretation of data.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Karina Baruel de Camargo Votto Calbucci: Drafting and editing of the manuscript; collection, analysis, and interpretation of data.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Rute Facchini Lellis: Collection, analysis and interpretation of data; effective participation in research orientation; critical review of the literature; critical review of the manuscript.</p><p id="par0055" class="elsevierStylePara elsevierViewall">John Verrinder Veasey: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; collection, analysis and interpretation of data; effective participation in research orientation; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:3 [ "identificador" => "xres1550373" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1400160" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Case report" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Financial support" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Authors’ contributions" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-07-08" "fechaAceptado" => "2020-09-29" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1400160" "palabras" => array:3 [ 0 => "Chromoblastomycosis" 1 => "Diagnosis" 2 => "Mycoses" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The detection of muriform cells in direct mycological or anatomopathological examination is considered pathognomonic for chromoblastomycosis. The morphological aspect that these fungal structures acquire were called “Borelli spiders”, when associated with hyphae. Reports of this association have been described for decades, initially related to more pathogenic agents of this mycosis. More recent studies have shown aspects related to the host's immunity that participate in this process, as well as an association with a worse disease prognosis. The present study discloses the findings of complementary examinations with the presence of “Borelli’s spiders” in a patient diagnosed with chromoblastomycosis.</p></span>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Carvalho GSM, Calbucci KBCV, Lellis RF, Veasey JV. Presence of hyphae in chromoblastomycosis examinations: an enigma to be solved. An Bras Dermatol. 2021;96:490–3.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Santa Casa de Misericórdia, São Paulo, SP, Brazil.</p>" ] ] "multimedia" => array:5 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1207 "Ancho" => 905 "Tamanyo" => 219976 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical aspect on the left thigh region, characterized by an erythematous plaque, with well-defined limits, a verrucous surface and some nodular areas that measured 13 cm at the largest axis.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 527 "Ancho" => 1305 "Tamanyo" => 70043 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mycological examination of a chromoblastomycosis case. (A and B), direct mycological examination (KOH 20%, ×200) showing the “Borelli spiders” in two different fields. (C and D), Fungal culture with macro-microscopic morphology compatible with <span class="elsevierStyleItalic">Fonsecaea pedrosoi</span>.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 681 "Ancho" => 905 "Tamanyo" => 178912 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathological analysis of chromoblastomycosis (Hematoxylin & eosin, ×40). Continuous arrow: muriform body (MB) in the center of an intraepidermal microabscess, pathognomonic of the disease. Dashed arrows: identification of septated dematiaceous hyphae.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 861 "Ancho" => 905 "Tamanyo" => 214075 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A – Histopathological analysis of chromoblastomycosis showing muriform bodies associated with dematiaceous hyphae, “Borelli spiders” (Fontana Masson, ×1000).</p>" ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 512 "Ancho" => 905 "Tamanyo" => 135562 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Histopathological analysis of chromoblastomycosis. 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