Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis | Anais Brasileiros de Dermatologia (Portuguese)

array:24 ["pii" => "S0365059621000015" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.08.008" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "302" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275221000011" "issn" => "26662752" "doi" => "10.1016/j.abdp.2021.02.001" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "302" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:12 [ "idiomaDefecto" => true "cabecera" => "Artigo original" "titulo" => "Níveis das interleucinas 17A, 22 e 23 e da família de proteínas S100 no fluido gengival crevicular de pacientes psoriásicos com ou sem periodontite" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "163" "paginaFinal" => "170" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3506 "Ancho" => 1250 "Tamanyo" => 181592 ] ] "descripcion" => array:1 [ "pt" => "Concentração de IL‐17, IL‐22 e IL‐23 no FCG dos indivíduos do estudo. H, controle saudável; P, indivíduos com periodontite não tratada; S, indivíduos com psoríase não tratada; SP, indivíduos com psoríase não tratada e periodontite não tratada." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Constanza Jiménez, Daniela Carvajal, Marcela Hernández, Fernando Valenzuela, Jessica Astorga, Alejandra Fernández" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Constanza" "apellidos" => "Jiménez" ] 1 => array:2 [ "nombre" => "Daniela" "apellidos" => "Carvajal" ] 2 => array:2 [ "nombre" => "Marcela" "apellidos" => "Hernández" ] 3 => array:2 [ "nombre" => "Fernando" "apellidos" => "Valenzuela" ] 4 => array:2 [ "nombre" => "Jessica" "apellidos" => "Astorga" ] 5 => array:2 [ "nombre" => "Alejandra" "apellidos" => "Fernández" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059621000015" "doi" => "10.1016/j.abd.2020.08.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000015?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000011?idApp=UINPBA00008Z" "url" => "/26662752/0000009600000002/v2_202104230742/S2666275221000011/v2_202104230742/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059621000064" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.09.002" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "307" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Prolonged luteal phase support with progesterone may increase papules and plaques of pregnancy frequency in pregnancies through in vitro fertilization" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "171" "paginaFinal" => "175" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nur Dokuzeylul Gungor, Tugba Gurbuz, Tugba Ture" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Nur" "apellidos" => "Dokuzeylul Gungor" ] 1 => array:2 [ "nombre" => "Tugba" "apellidos" => "Gurbuz" ] 2 => array:2 [ "nombre" => "Tugba" "apellidos" => "Ture" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221000060" "doi" => "10.1016/j.abdp.2020.09.020" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000060?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000064?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000064/v2_202104300920/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S036505962100012X" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.05.015" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "313" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Gene panel for the diagnosis of epidermolysis bullosa: proposal for a viable and efficient approach" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "155" "paginaFinal" => "162" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2038 "Ancho" => 2175 "Tamanyo" => 316531 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Gene panel as the first choice for the diagnosis of EB: main characteristics. Gene panel has high efficiency and precision, a price comparable to other EB diagnostic methods, and eliminates the need for skin biopsy. The cost of NGS technology has been decreasing, which indicates that the gene panel should become more accessible in the coming years. Identification of the genetic alteration allows establishing disease prognosis, prenatal and pre-implantation genetic diagnosis, has implications for genetic counseling, and is important for the development of future therapies for EB." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luiza Monteavaro Mariath, Ana Elisa Kiszewski, Jeanine Aparecida Frantz, Marina Siebert, Ursula Matte, Lavínia Schuler-Faccini" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Luiza Monteavaro" "apellidos" => "Mariath" ] 1 => array:2 [ "nombre" => "Ana Elisa" "apellidos" => "Kiszewski" ] 2 => array:2 [ "nombre" => "Jeanine Aparecida" "apellidos" => "Frantz" ] 3 => array:2 [ "nombre" => "Marina" "apellidos" => "Siebert" ] 4 => array:2 [ "nombre" => "Ursula" "apellidos" => "Matte" ] 5 => array:2 [ "nombre" => "Lavínia" "apellidos" => "Schuler-Faccini" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221000126" "doi" => "10.1016/j.abdp.2020.05.031" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000126?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962100012X?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000002/v2_202104300920/S036505962100012X/v2_202104300920/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "163" "paginaFinal" => "170" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Constanza Jiménez, Daniela Carvajal, Marcela Hernández, Fernando Valenzuela, Jessica Astorga, Alejandra Fernández" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Constanza" "apellidos" => "Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Daniela" "apellidos" => "Carvajal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Marcela" "apellidos" => "Hernández" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 3 => array:3 [ "nombre" => "Fernando" "apellidos" => "Valenzuela" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Jessica" "apellidos" => "Astorga" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 5 => array:4 [ "nombre" => "Alejandra" "apellidos" => "Fernández" "email" => array:1 [ 0 => "alejandra.fernandez@unab.cl" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Oral Pathology, Faculty of Dentistry, Universidad Andrés Bello, Santiago, Chile" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Dermatology, Faculty of Medicine, Universidad de Chile, Santiago, Chile" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago, Chile" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Oral Pathology and Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, Chile" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2317 "Ancho" => 1250 "Tamanyo" => 106195 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Concentration of S100A7 and S100A8 in GCF of study individuals. Bars and asterisk represent p." ] ] ] "textoCompleto" => "IntroductionPsoriasis is a chronic immunologically mediated inflammatory dermatosis and recurrent autoimmune disease that occurs in genetically susceptible individuals. Psoriasis is common; its prevalence is about 2% in Europe and North America. The main clinical skin manifestations include itching, burning, and soreness, accompanied by the development of well-defined, scaly, erythematous plaque lesions resulting from abnormal proliferation and differentiation of keratinocytes.<a class="elsevierStyleCrossRef" href="#bib0005">1</a>The pathogenesis of psoriasis remains unclear; however, interactions between keratinocytes and resident skin T cells within the interleukin (IL) 23/Th17 pathway appear to participate in the onset and progression of the disease.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> Evidence supporting this hypothesis includes the isolation of IL-23 and IL-17 mRNA from psoriatic skin lesions and the report of increased serum concentrations of IL-17A, IL-22, and IL-23 in psoriatic patients vs. healthy controls.<a class="elsevierStyleCrossRefs" href="#bib0015">3–5</a> In recent years, special attention has been given to the prospective role of S100 proteins in the development of psoriasis. The S100 protein family is composed of calcium-binding proteins, in which psoriasin (S100A7) and calgranulin A (S100A8) are regulated by IL-17, amplifying the inflammatory response. S100A7, S100A8, and calgranulin B (S100A9) have been reported to express in psoriatic skin-lesions revealing these S100 proteins could play a key role in the unregulated growth and differentiation of keratinocytes in the skin of psoriatic patients.<a class="elsevierStyleCrossRefs" href="#bib0030">6–9</a> Additionally, it has been indicated S100 proteins act as a chemotactic factors for immune cells, inducing a pro-inflammatory environment in which the onset and recurrence of psoriasis may easily occur.<a class="elsevierStyleCrossRef" href="#bib0045">9</a>Recently, epidemiological studies have associated psoriasis with periodontitis, suggesting a common underlying immunopathogenesis.<a class="elsevierStyleCrossRefs" href="#bib0050">10,11</a> Although studies on the subject are scarce, results are particularly interesting since a potentially bidirectional relationship between the two diseases has been suggested. In these studies, psoriatic patients not only presented a higher frequency of periodontitis and worse periodontal parameters, but also an increased risk of developing periodontitis compared to non-psoriatic healthy controls.<a class="elsevierStyleCrossRefs" href="#bib0060">12–14</a> Furthermore, a potential dose-response relationship between psoriasis and periodontitis was reported by Egeberg et al.<a class="elsevierStyleCrossRef" href="#bib0050">10</a> as the frequency of periodontitis increased when the severity of the psoriasis augmented. Some evidence indicates periodontal patients might have an increased frequency and risk of psoriasis; nonetheless, more evidence is still needed. In the same line as psoriasis, the pathogenesis of periodontitis includes a special involvement of the IL-23/Th17 pathway. The expression of IL-17, IL-22, and IL-23 has been evaluated in the gingival crevicular fluid (GCF) of patients with chronic periodontitis, and these cytokines have been associated with the pathogenesis and severity of the disease and alveolar bone resorption.<a class="elsevierStyleCrossRefs" href="#bib0075">15–17</a> In periodontitis, studies have detected a S100A8/S100A9 heterocomplex in GCF, saliva, and serum of patients with periodontitis, whereas a recent study associated periodontitis with elevated levels of salivary S100A8.<a class="elsevierStyleCrossRefs" href="#bib0090">18–21</a> To date, there has been no evidence to evaluate the expression of IL-23/Th17-related cytokines and S100-family proteins in the GCF of psoriatic patients. Due to GCF comprising diagnosis biomarkers of oral and systemic diseases as well as accurately exposing the constituents of serum and the cellular reactions of the periodontium, it is hypothesized that the levels of cytokines involved in T-cell regulation and S100 protein family molecules in GCF will show marked differences in psoriatic and healthy individuals with or without periodontitis, reflecting the link between psoriasis and periodontitis.<a class="elsevierStyleCrossRef" href="#bib0110">22</a> Hence, the aim of this study was to evaluate the levels of IL-17A, IL-22, IL-23, S100A7, S100A8, and S100A9 in GCF of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity.MethodsThe present cross-sectional study was approved by the bioethics committee of the North Metropolitan Health Service, Santiago, Chile (N52/2017). All participants provided written informed consent prior to study enrollment, in accordance with the Helsinki Declaration.Selection of patientsIndividuals referred for presumed diagnosis of psoriasis to the dermatology unit of San José Hospital, Santiago, Chile, were enrolled over a ten-month period (2018). Individuals without psoriasis were simultaneously selected from volunteering patients attending the dental clinic of the Faculty of Dentistry of Andres Bello University, Santiago, Chile. Global eligibility criteria included the following: I) adult patients (≥ 18 years) with II) eleven or more teeth (excluding third molars). Exclusion criteria were set as follows: I) individuals with any known systemic disorders/conditions other than psoriasis (especially those involving inflammatory/immune dysregulation such as diabetes, systemic lupus, and arthritis/osteoarthritis, among others), II) patients who had received antibiotic, nonsteroidal anti-inflammatory, and/or immunomodulatory therapy in the last three months, III) patients who had undergone radiotherapy and/or chemotherapy in the last year, and IV) patients who had received periodontal or/and psoriasis treatment in the last six months.Clinical measurementsAll patients were evaluated by the same team of experts. Dermatological data were collected from the initial consultation by dermatologists from the hospital staff. Clinical confounder variables evaluated included sex and age. Clinical psoriasis variables included presence or absence of psoriasis, clinical type of psoriasis, and psoriasis severity, defined by the (a) Psoriasis Area and Severity Index (PASI), (b) body surface area (BSA), the (c) static Physician’s Global Assessment (PGA), and the Dermatology Life Quality Index (DLQI). Periodontal evaluation and sampling were performed by a qualified periodontist. Clinical periodontal evaluation included full-mouth manual periodontal charting (six sites per tooth, excluding third molars) and recording of the following parameters: probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and tooth loss. Additional information regarding oral hygiene habits and smoking were collected. Periodontal status was defined according to the clinical case definition of periodontitis proposed by the Centers for Disease Control and Prevention (CDC), United States. Severe periodontitis was defined as two or more interproximal sites with CAL≥6mm (not on the same tooth) and ≥ 1 interproximal site with PD≥5mm. Moderate periodontitis was defined as two or more interproximal sites with CAL≥4mm (not on the same tooth) and/or two or more interproximal sites with PD≥5mm. Finally, no/mild cases of periodontitis were defined as neither severe nor moderate periodontitis.<a class="elsevierStyleCrossRef" href="#bib0115">23</a>From a total of 93 individuals evaluated, 82 met the inclusion criteria. Subjects were divided into the following groups: H, systemically healthy controls with no/mild periodontitis; P, systemically healthy controls with moderate/severe periodontitis; S, individuals with psoriasis with no/mild periodontitis; and SP, individuals with psoriasis and moderate/severe periodontitis. Finally, from an ethical standpoint, it must be noted that all patients examined in this study with a positive diagnosis for either psoriasis and/or periodontitis were referred for timely treatment at San José Hospital and/or the dental clinic of Andres Bello University, respectively.Gingival crevicular fluid (GCF) collectionSamples were obtained from four independent sites based on probing depth, deepest site per quadrant. Before sampling, sites were isolated with cotton rolls and then carefully dried with an air-syringe to prevent saliva contamination. GCF was collected using sterile periodontal strips (Periopaper®; Interstate Drug Exchange – Amityville, NY, United States) gently inserted into the gingival sulcus or pocket until mild resistance was noticed. After 30 seconds, strips were collected into sterile tubes and immediately transported to the laboratory for storage (−20°C) and posterior analysis.GCF analysisA 40μL elution/strip was prepared using protein elution buffer into sterile tubes. Samples were incubated for half an hour at 4°C and then centrifuged at 12,000 × g for five minutes at 4°C. The procedure was repeated twice, and samples were frozen and kept at −20°C until analysis. Aliquots from all GCF samples were used for protein quantification using a multiplex assay panel (Human Magnetic Luminex Assay®; R&D Systems – MN, United States) for Il-17A, Il-22, IL-23, S100A8, and S100A9, and an ELISA Kit (Human Protein S100-A7 Elisa Kit®; MyBioSource Inc – San Diego, CA, United States) for S100A7, according to the manufacturers’ instructions. Data from the multiplex analysis panel were read using a platform (Magpix; Millipore – St. Charles, MO, United States) and then analyzed using software (MILLIPLEX AnalystR; Viagene Tech – Carlisle, MA, United States).Statistical analysisThe Shapiro-Wilk test and Levene’s test were used to determine the distribution and homoscedasticity of the data, respectively. Inferential analyses were performed with Fisher’s exact test, analysis of variance (ANOVA), and Duncan’s post hoc test. An ANOVA model type III was applied with a covariate: the age of the subjects examined. The correlation coefficients were obtained using Spearman’s correlation analysis. The level of significance was defined as p < 0.05. The effect size (eta-squared) was calculated, shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The statistical analysis was performed using a statistical software (STATA 12®; StataCorp – College Station, TX, United States). It must be noted that as a result of the explorative nature of this research, no sample-size calculation was performed.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>ResultsIn total, 82 individuals were included in this study: 21 controls with no/mild periodontitis (H), 18 controls with moderate/severe periodontitis (P), 11 individuals with psoriasis and no/mild periodontitis (S), and 32 individuals with psoriasis and moderate/severe periodontitis (SP).Demographic data, habits, and clinical parameters of all individuals in this study are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. No significant differences among groups regarding gender, smoking, BOP, and oral hygiene habits, PASI, BSA, PGA, and DLQI were found. The highest mean age was found in the SP group, followed by groups P, S, and H in decreasing order. Only the SP group showed significant differences in mean age with group H (p < 0.05).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Regarding periodontal clinical parameters, PD was significantly worse/deeper in the SP group compared to groups S, P, and H (p < 0.05). The P group presented significantly deeper pockets than the H group (p < 0.05). The highest CAL was observed in the SP group compared to that for groups S, P, and H (p < 0.05). The highest tooth loss was observed in the SP group, followed by groups S, P, and H in decreasing order. Regarding dermatological clinical data, no significant differences in PASI, BSA, and PGA were found between groups S and SP.The concentrations of IL-17A, IL-22, and IL-23 in the GCF are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. No intergroup differences regarding the levels of IL-17A, IL-22, and IL-23 in GCF were noted. The GCF levels of IL-17A, IL-22, and IL-23 in the SP group showed a tendency to be higher than those of the S group, respectively. GCF concentrations of S100A7 and S100A8 in the different groups are presented in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. No significant differences in the levels of S100A7 in the GCF of the different groups were observed. Group H presented the lowest levels of S100A8 compared to the S and SP groups (p < 0.05). Additionally, group P presented lower levels of S100A8 compared to the S and SP groups (p < 0.05). Nevertheless, age demonstrated no influence upon the concentration of all interleukins and the S100 protein family (p>0.05). Concentrations of S100A9 in the GCF of all groups exceeded the upper-detection limits of the ELISA kit; therefore, exact quantification and analysis were not possible.<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia>The levels of inflammatory mediators in GCF were correlated with the periodontal clinical parameters in group H and group P. In group H, IL-17A levels were negatively correlated with CAL (-0.499), (p<0.05). In group P, IL-22 was positively correlated with PD (0.490) and CAL (0.589) (p<0.05). In groups S and SP, correlations between inflammatory mediators and both periodontal and dermatological clinical parameters were obtained. In the S group, IL-23 was negatively correlated with PGA, whereas S100A8 was positively and strongly correlated with PASI (0.878), BSA (0.851), and DLQI (0.622) (p<0.05). In the SP group, IL-22 and IL-23 were negatively correlated with BSA (-0.358 and -0.468, respectively, p<0.05).DiscussionPsoriasis and periodontitis share similar mechanisms of immune dysregulation, characterized by a Th17 axis-predominant immune response.<a class="elsevierStyleCrossRefs" href="#bib0120">24,25</a> The Th17 pathway regulates the expression of S100 proteins, which may participate in the pathogenesis of both diseases.<a class="elsevierStyleCrossRefs" href="#bib0130">26–28</a> In the present study, elevated levels of S100A8 were found in the GCF of psoriatic patients compared to that of systemically healthy controls, regardless of their periodontal health/status; there was a strong positive correlation between S100A8 with BSA, PASI, and DLQI in the psoriasis group (group S), suggesting that GCF concentrations of S100A8 could be a promising non-invasive biomarker for the presence and severity of psoriasis.To the best of the authors’ knowledge, no previous studies have evaluated the GCF concentrations of S100A7 and S100A8 in psoriatic individuals with or without periodontitis. In periodontitis alone, S100A7 and S100A8 have been detected in the GCF of individuals with periodontitis using the techniques of mass spectrometry and western blot, indicating these molecules might participate in the immune response of periodontal tissues.<a class="elsevierStyleCrossRef" href="#bib0145">29</a> In addition, S100A7 and S100A8 could be involved in periodontal bone resorption, as evidence shows S100A8 induced osteoclastic bone resorption in experimental arthritis 30 and S100A7 stimulated osteoclast differentiation in human monocytes in vitro.<a class="elsevierStyleCrossRefs" href="#bib0150">30,31</a> Recently, Karna et al. reported and associated increased levels of salivary S100A8 with periodontitis in Korean adults, suggesting salivary concentrations of S100A8 could be a prospective biomarker for periodontitis.<a class="elsevierStyleCrossRef" href="#bib0105">21</a> In psoriasis, S100A7 has been reported to induce unregulated differentiation of the epidermis.<a class="elsevierStyleCrossRef" href="#bib0040">8</a> It is thought that S100A7 functions as a keratinocyte-derived chemotactic agent for immune cells, as a result the molecule strongly attracts CD4+ lymphocytes and neutrophils under inflammatory stress. S100A8 and S100A9 molecules are initially released from keratinocytes to start/prompt immune cell invasion, which is further sustained by the later release of the same molecules from incoming neutrophils.<a class="elsevierStyleCrossRef" href="#bib0140">28</a> The detection of different S100 family proteins in serum has been proposed as prospective biomarker for psoriasis, as increased levels of S100A7 and S100A8 have been detected in blood samples of untreated psoriatic patients compared with non-psoriatic healthy individuals. Moreover, gene expression of S100A7 and S100A8 in psoriatic skin lesions has been reported to be significantly higher than that of healthy skin samples.<a class="elsevierStyleCrossRef" href="#bib0140">28</a>The present findings show S100A8 presents in higher concentrations in the GCF of psoriatic patients vs. non-psoriatic healthy controls, regardless of their periodontal health/status. Nonetheless, the concentrations of S100A7 between groups presented no differences. Therefore, in line with previously reported evidence, these results suggest that S100A8 may be a key protein involved in the pathogenesis of psoriasis. In addition, it is believed that S100A8 could reflect the presence and severity of psoriasis, thus presenting as a promising, safe, non-invasive biomarker for early diagnosis of the disease regardless of periodontal health. Increased levels of S100A8 in the GCF samples of psoriatic subjects might be explained by the systemic dissemination of the molecules from active psoriatic skin lesions: It is possible that active psoriatic skin lesions may function as local spots for the massive production of S100A8, which then enters the blood stream via increased vascular permeability and travels to distant sites, such as the oral gingiva.<a class="elsevierStyleCrossRef" href="#bib0160">32</a>The present study observed that overall concentrations of IL-17A, IL-22, and IL-23 presented a tendency to increase in psoriatic patients with moderate/severe periodontitis (group SP) compared to psoriatic patients with no/mild periodontitis (group S). These findings could be attributed to a local effect of periodontitis. According to the literature, IL-17, IL-22, and IL-23 are associated with osteoclastogenesis in periodontitis; however, their concentrations within the oral fluids of periodontal patients remains controversial.<a class="elsevierStyleCrossRefs" href="#bib0085">17,33–35</a> In one study, IL-17A levels in serum, saliva, and GCF were higher in periodontitis than in healthy controls.<a class="elsevierStyleCrossRef" href="#bib0180">36</a> In contrast, another study reported higher levels of IL-17 in the GCF of healthy individuals than in subjects with either chronic or aggressive periodontitis.<a class="elsevierStyleCrossRef" href="#bib0185">37</a> In relation to IL-22, a previous study reported no differences in the saliva concentrations of IL-22 of individuals with chronic periodontitis vs. healthy controls.<a class="elsevierStyleCrossRef" href="#bib0190">38</a> However, an additional study reported higher levels of IL-22 in the GCF of subjects with periodontitis compared with those of subjects with gingivitis and healthy individuals 17. Regarding IL-23, a study reported higher concentrations of the molecule in the GCF of patients with chronic periodontitis vs. healthy controls.<a class="elsevierStyleCrossRef" href="#bib0195">39</a> In contrast, R. Sadeghi et al. reported higher concentrations of IL-23 in the GCF of healthy subjects compared to patients with chronic periodontitis.<a class="elsevierStyleCrossRef" href="#bib0185">37</a> It is theorized that these discrepancies may be due to differences in the methods used to quantify the concentrations of the above-mentioned proteins, as well as the absence of consensus regarding clinical case definitions of periodontitis.<a class="elsevierStyleCrossRef" href="#bib0115">23</a>Previously, the detection of IL-17 in the serum and skin of patients with psoriasis has been reported, while not in GCF. Differences in the concentration of IL-17 in serum samples of psoriatic patients vs. those of healthy controls is controversial.<a class="elsevierStyleCrossRefs" href="#bib0025">5,40,41</a> However, skin psoriatic biopsies have shown higher expression of IL-17A than those of healthy subjects.<a class="elsevierStyleCrossRef" href="#bib0210">42</a> Differences between the present results and those previously reported in the literature may be due to the different time points in the history of psoriasis.<a class="elsevierStyleCrossRef" href="#bib0025">5</a> There are no previous studies reporting the presence of IL-17 in the GCF of individuals with psoriasis with or without periodontitis; however, higher levels of IL-17A have been detected in the GCF of individuals with other autoimmune diseases and periodontitis. Such is the case of rheumatoid arthritis patients with periodontitis, who have presented higher levels of IL-17A than those of systemically healthy subjects with periodontal disease.<a class="elsevierStyleCrossRef" href="#bib0215">43</a> In addition, an experimental animal study has shown an increase in IL-17 production by lymph node T-cells in arthritic mice with periodontitis compared with that in arthritic mice without periodontitis.<a class="elsevierStyleCrossRef" href="#bib0220">44</a> Another study showed that periodontitis seems to alter IL-17 levels in gingival tissue samples of arthritic rats.<a class="elsevierStyleCrossRef" href="#bib0225">45</a>Regarding psoriasis, it has been reported that IL-22 and IL-23 are required to induce psoriasis-like lesions in animal models.<a class="elsevierStyleCrossRefs" href="#bib0230">46,47</a> Similarly to the present results, some studies have reported no differences in the levels of IL-22 and IL-23 in the serum of patients with psoriasis vs. those of healthy controls.<a class="elsevierStyleCrossRefs" href="#bib0240">48,49</a> However, only one study reported increased concentrations of IL-22 and IL-23 in the serum of psoriatic patients vs. those of non-psoriatic healthy controls.<a class="elsevierStyleCrossRef" href="#bib0025">5</a> These findings suggest that IL-22 and IL-23 may act preferentially at a local level in psoriasis. All these antecedents support the potential role of periodontitis in the tendency to increased levels of IL-17, IL-22, and IL-23 in the SP group compared to the S group shown in the present study. In this study, the no/mild cases of periodontitis within groups H and S could have partially masked the net differences between healthy non-periodontal controls and periodontal patients.Regarding the correlations between GCF inflammatory mediators and periodontal disease, it was found that group H had a negative correlation between the levels of IL-17A and CAL, whereas group P had a positive correlation between IL-22 and PD and CAL. These findings suggest that these inflammatory mediators participate in periodontal disease pathogenesis, which has been previously suggested in the literature, as both interleukins have been linked to osteoclastogenesis in periodontal disease.<a class="elsevierStyleCrossRefs" href="#bib0085">17,35</a>Although the IL-23/Th17 pathway is part of cutaneous inflammation in psoriasis, a negative correlation was detected between IL-23 and PGA in group S. In addition, a negative correlation was found between IL-22 and IL-23 in group SP. This result could be explained by the diverging phenotype in psoriasis.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> To the authors’ knowledge, this study is the first article to report that GCF levels of S100A8 correlate positively with BSA, PASI, and DLQI in individuals with psoriasis, suggesting that S100A8 in GCF may serve as a potential biomarker of presence and severity of psoriasis. This may be justified by the high expression of S100A8 in the epidermis of psoriatic skin.<a class="elsevierStyleCrossRef" href="#bib0250">50</a>This pilot study presents a small sample size, which the authors acknowledge as a limitation. Nonetheless, the number of individuals included allowed for the identification of changes in the GCF of individuals with and without psoriasis. Therefore, more studies are essential to elucidate the potential link between periodontitis and psoriasis.ConclusionsThe concentrations of S100A8 were highest in the GCF of psoriatic patients regardless of their periodontal health/status. Furthermore, S100A8 in GCF was associated with the severity of psoriasis. The concentrations of interleukins and S100A7 were similar in GCF of psoriatic patients with or without periodontitis in relation to healthy controls. Therefore, the immune molecules evaluated in GCF in the present study do not seem to reflect the link between periodontitis and psoriasis.Financial supportThis research was supported by a grant from Dirección General de Investigación de la Universidad Andrés Bello (DGI-UNAB), No. DI-36-18/CBC, and FONDECYT, No. 1160741.Authors' contributionsConstanza Jiménez: Approval of the final version of the manuscript; study conception and planning; preparation and writing of the manuscript; data collection, analysis, and interpretation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.Daniela Carvajal: Approval of the final version of the manuscript; preparation and writing of the manuscript; data collection, analysis, and interpretation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.Marcela Hernández: Approval of the final version of the manuscript; study conception and planning; preparation and writing of the manuscript; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.Fernando Valenzuela: Approval of the final version of the manuscript; study conception and planning; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.Jessica Astorga: Approval of the final version of the manuscript; collection, analysis, and interpretation of data; critical review of the manuscript.Alejandra Fernández: Approval of the final version of the manuscript; study conception and planning; preparation and writing of the manuscript; data collection, analysis, and interpretation; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.Conflicts of interestNone declared." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1505251" "titulo" => "Abstract" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Study limitations" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1366007" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Selection of patients" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Clinical measurements" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Gingival crevicular fluid (GCF) collection" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "GCF analysis" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Statistical analysis" ] ] ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusions" ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Financial support" ] 8 => array:2 [ "identificador" => "sec0060" "titulo" => "Authors' contributions" ] 9 => array:2 [ "identificador" => "sec0065" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-12-19" "fechaAceptado" => "2020-08-04" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1366007" "palabras" => array:4 [ 0 => "Cytokinesis" 1 => "Periodontal diseases" 2 => "Psoriasis" 3 => "S100 proteins" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "BackgroundPsoriasis and periodontitis are immunologically mediated chronic inflammatory diseases. Epidemiologic evidence has linked both; however, the change of markers in gingival crevicular fluid has been poorly evaluated. ObjectiveTo evaluate the levels of IL-17A, IL-22, IL-23, S100A7, S100A8, and S100A9 in gingival crevicular fluid of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity. MethodsCross-sectional study. Sample comprised the following groups: healthy controls without periodontitis or with mild periodontitis (n=21), healthy controls with moderate or severe periodontitis (n=18), individuals with psoriasis without or mild periodontitis (n=11), and individuals with psoriasis and moderate or severe periodontitis (n=32). Levels of IL-17A, IL-22, IL-23, S100A8, and S100A9 were determined by multiplex assay and S100A7 was measured by ELISA. ResultsNo inter-group differences in the levels of IL-17A, IL-22, IL-23, and S100A7 were found. S100A8 levels were higher in psoriatic patients than controls (p<0.05). S100A8 was positively correlated with psoriasis severity in the group with psoriasis (p<0.05). S100A9 exceeded the detection limits. Study limitationsThis pilot study presents a small sample size. ConclusionsThe concentrations of S100A8 were highest in psoriatic patients regardless of periodontal health/status. S100A8 was associated with the severity of psoriasis. The concentrations of interleukins and S100A7 were similar in psoriatic patients with or without periodontitis vs. healthy controls." "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Study limitations" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusions" ] ] ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "How to cite this article: Jiménez C, Carvajal D, Hernández M, Valenzuela F, Astorga J, Fernández A. Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis. An Bras Dermatol. 2021;96:163–70." ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "Study conducted at the Universidad Andrés Bello and Universidad de Chile, Hospital San Jose, Santiago, Chile." ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3506 "Ancho" => 1250 "Tamanyo" => 187269 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Concentration of IL-17, IL-22, and IL-23 in the GCF of study individuals. H, healthy control; P, individuals with untreated periodontitis; S, individuals with untreated psoriasis; SP, individuals with untreated psoriasis and untreated periodontitis." ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2317 "Ancho" => 1250 "Tamanyo" => 106195 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Concentration of S100A7 and S100A8 in GCF of study individuals. Bars and asterisk represent p." ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age (covariate) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age (covariate) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eta-squared groups \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IL-17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=3.83 (p=0.054) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=1.26 (p=0.295) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.047 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IL-22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=1.19 (p=0.279) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=0.36 (p=0.784) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.014 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IL-23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=1.54 (p=0.218) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=0.68 (p=0.565) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.026 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S100A7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=0.23 (p=0.629) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=0.57 (p=0.635) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S100A8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=0.75 (p=0.388) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F=8.62 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.251 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2585820.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Results of effect size for analysis of variance (ANOVA): eta squared." ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Bold, p<0.05; H, healthy control; P, individuals with untreated periodontitis; S, individuals with untreated psoriasis; SP, individuals with untreated psoriasis and untreated periodontitis; SD, standard deviation; PD, probing depth; CAL, clinical attachment level; BOP, bleeding on probing; PASI, Psoriasis Area Severity Index; BSA, body surface area; PGA, Physician’s Global Assessment; DLQI, Dermatology Life Quality Index.Superscript letters indicate significant differences among groups: a Present significant difference with whereas b whereas c present significant difference withd." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Parameters \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">H \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">S \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SP \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years, mean [SD]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33.52 (10.64)a \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42.95 (12.48) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40.16 (16.82) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.20 (11.43)b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gender: male-female (n) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9–12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12–6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5–6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13–19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.342 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Smokers (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (28.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (33.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (27.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (53.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.235 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PD (mm, mean [SD]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.86 (0.24)a \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.24 (0.42)b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.99 (0.5)b,c \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.53 (0.43)d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CAL (mm, mean [SD]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.33 (0.44)b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.70 (0.64)b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.56 (0.95)b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.75 (1.26)a \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BOP (%, mean [SD]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.36 (21.86) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.80 (12.33) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.16 (9.18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.60 (14.06) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.240 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of teeth (n, mean [SD]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.24 (3.62)b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25(2.54)b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.8(4.28) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.67 (4.84)a \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Frequency of dental brushing (n per day, mean [SD]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.56 (0.76) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.86 (0.88) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.09(0.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.24 (1.11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.054 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PASI, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.7 (7.91) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.35 (6.40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.153 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BSA, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.20 (13.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.08 (15.19) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.531 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PGA, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.67 (0.76) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.193 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DLQI, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.83 (6.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.79 (7.71) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.704 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2585821.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Comparison of demographic parameters, smoking habits, and clinical characteristics of study individuals." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:50 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W.H. Boehncke" 1 => "M.P. Schon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(14)61909-7" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2015" "volumen" => "386" "paginaInicial" => "983" "paginaFinal" => "994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26025581" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current knowledge on psoriasis and autoimmune diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Ayala-Fontanez" 1 => "D.C. Soler" 2 => "T.S. McCormick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Psoriasis (Auckl)" "fecha" => "2016" "volumen" => "6" "paginaInicial" => "7" "paginaFinal" => "32" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.S. Oliveira" 1 => "M.C. Pereira" 2 => "S.K. Silva de Paula" 3 => "E.V. Lima" 4 => "M.M. Lima" 5 => "R.G. Arruda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Mediators Inflamm" "fecha" => "2016" "volumen" => "2016" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Piskin" 1 => "R.M. Sylva-Steenland" 2 => "J.D. Bos" 3 => "M.B. Teunissen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4049/jimmunol.176.3.1908" "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "2006" "volumen" => "176" "paginaInicial" => "1908" "paginaFinal" => "1915" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16424222" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-17A, IL-22, and IL-23 as Markers of Psoriasis Activity: A Cross-sectional, Hospital-based Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Fotiadou" 1 => "E. Lazaridou" 2 => "E. Sotiriou" 3 => "S. Gerou" 4 => "A. Kyrgidis" 5 => "E. Vakirlis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1203475415584503" "Revista" => array:6 [ "tituloSerie" => "J Cutan Med Surg" "fecha" => "2015" "volumen" => "19" "paginaInicial" => "555" "paginaFinal" => "560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25917082" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Benoit" 1 => "A. Toksoy" 2 => "M. Ahlmann" 3 => "M. Schmidt" 4 => "C. Sunderkotter" 5 => "D. Foell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2006" "volumen" => "155" "paginaInicial" => "62" "paginaFinal" => "66" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "S100A7, Jab1, and p27(kip1) expression in psoriasis and S100A7 CRISPR-activated human keratinocyte cell line" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Granata" 1 => "E. Skarmoutsou" 2 => "P. Gangemi" 3 => "M.C. Mazzarino" 4 => "F. D’Amico" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jcb.27609" "Revista" => array:6 [ "tituloSerie" => "J Cell Biochem" "fecha" => "2019" "volumen" => "120" "paginaInicial" => "3384" "paginaFinal" => "3392" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30203426" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.K. Ekman" 1 => "J. Vegfors" 2 => "C.B. Eding" 3 => "C. Enerback" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-2596" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2017" "volumen" => "97" "paginaInicial" => "441" "paginaFinal" => "448" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27958610" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Lee" 1 => "S. Jang" 2 => "J.K. Min" 3 => "K. Lee" 4 => "K.C. Sohn" 5 => "J.S. Lim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem Biophys Res Commun." "fecha" => "2012" "volumen" => "423" "paginaInicial" => "647" "paginaFinal" => "653" "itemHostRev" => array:3 [ "pii" => "S0140673603128887" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of periodontitis in patients with psoriasis and psoriatic arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Egeberg" 1 => "L. Mallbris" 2 => "G. Gislason" 3 => "P.R. Hansen" 4 => "U. Mrowietz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.13814" "Revista" => array:7 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2017" "volumen" => "31" "paginaInicial" => "288" "paginaFinal" => "293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27439545" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0190962210008674" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between moderate to severe psoriasis and periodontitis in a Scandinavian population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Skudutyte-Rysstad" 1 => "E.M. Slevolden" 2 => "B.F. Hansen" 3 => "L. Sandvik" 4 => "H.R. Preus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1472-6831-14-139" "Revista" => array:5 [ "tituloSerie" => "BMC Oral Health." "fecha" => "2014" "volumen" => "14" "paginaInicial" => "139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25427764" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of chronic plaque psoriasis and severe periodontitis: a hospital based case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Lazaridou" 1 => "A. Tsikrikoni" 2 => "C. Fotiadou" 3 => "E. Kyrmanidou" 4 => "E. Vakirlis" 5 => "C. Giannopoulou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2012.04615.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2013" "volumen" => "27" "paginaInicial" => "967" "paginaFinal" => "972" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22703187" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Periodontal disease: an oral manifestation of psoriasis or an occasional finding?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Ganzetti" 1 => "A. Campanati" 2 => "A. Santarelli" 3 => "V. Pozzi" 4 => "E. Molinelli" 5 => "I. Minnetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ddr.21194" "Revista" => array:7 [ "tituloSerie" => "Drug Dev Res." "fecha" => "2014" "volumen" => "75" "numero" => "Suppl 1" "paginaInicial" => "S46" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25381976" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased risk of periodontitis in patients with psoriatic disease: a nationwide population-based retrospective cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N.Y. Su" 1 => "J.Y. Huang" 2 => "C.J. Hu" 3 => "Chang Y.C. Yu HC" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7717/peerj.4064" "Revista" => array:5 [ "tituloSerie" => "PeerJ." "fecha" => "2017" "volumen" => "5" "paginaInicial" => "e4064" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29158990" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Periodontal disease and risk of psoriasis among nurses in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Nakib" 1 => "J. Han" 2 => "T. Li" 3 => "K. Joshipura" 4 => "A.A. Qureshi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Odontol Scand." "fecha" => "2013" "volumen" => "71" "paginaInicial" => "1423" "paginaFinal" => "1429" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression levels of th-2 and th-17 characteristic genes in healthy tissue versus periodontitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Behfarnia" 1 => "R. Birang" 2 => "S.S. Pishva" 3 => "M.G. Hakemi" 4 => "M.M. Khorasani" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dent (Tehran)" "fecha" => "2013" "volumen" => "10" "paginaInicial" => "23" "paginaFinal" => "31" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased levels of the T-helper 22-associated cytokine (interleukin-22) and transcription factor (aryl hydrocarbon receptor) in patients with periodontitis are associated with osteoclast resorptive activity and severity of the disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Diaz-Zuniga" 1 => "S. Melgar-Rodriguez" 2 => "L. Rojas" 3 => "C. Alvarez" 4 => "G. Monasterio" 5 => "P. Carvajal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Periodontal Res" "fecha" => "2017" "volumen" => "52" "paginaInicial" => "893" "paginaFinal" => "902" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical significance of GCF sIL-6R and calprotectin to evaluate the periodontal inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Kajiura" 1 => "J.H. Lew" 2 => "T. Ikuta" 3 => "Y. Nishikawa" 4 => "J.I. Kido" 5 => "T. Nagata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0004563216680232" "Revista" => array:6 [ "tituloSerie" => "Ann Clin Biochem" "fecha" => "2017" "volumen" => "54" "paginaInicial" => "664" "paginaFinal" => "670" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27810997" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calprotectin, a leukocyte protein related to inflammation, in gingival crevicular fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Kido" 1 => "T. Nakamura" 2 => "R. Kido" 3 => "K. Ohishi" 4 => "N. Yamauchi" 5 => "M. Kataoka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0765.1998.tb02340.x" "Revista" => array:6 [ "tituloSerie" => "J Periodontal Res." "fecha" => "1998" "volumen" => "33" "paginaInicial" => "434" "paginaFinal" => "437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9842509" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative Analysis of Calcium-Binding Myeloid-Related Protein-8/14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Haririan" 1 => "O. Andrukhov" 2 => "E. Pablik" 3 => "M. Neuhofer" 4 => "A. Moritz" 5 => "X. Rausch-Fan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1902/jop.2015.150254" "Revista" => array:6 [ "tituloSerie" => ". J Periodontol" "fecha" => "2016" "volumen" => "87" "paginaInicial" => "184" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26447749" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Salivary S100 proteins screen periodontitis among Korean adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Karna" 1 => "Y.J. Shin" 2 => "S. Kim" 3 => "H.D. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jcpe.13059" "Revista" => array:6 [ "tituloSerie" => "J Clin Periodontol." "fecha" => "2019" "volumen" => "46" "paginaInicial" => "181" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30592072" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.B. Lamster" 1 => "J.K. Ahlo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1196/annals.1384.027" "Revista" => array:6 [ "tituloSerie" => "Ann N Y Acad Sci" "fecha" => "2007" "volumen" => "1098" "paginaInicial" => "216" "paginaFinal" => "229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17435131" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case definitions for use in population-based surveillance of periodontitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.C. Page" 1 => "P.I. Eke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1902/jop.2007.060264" "Revista" => array:7 [ "tituloSerie" => "J Periodontol." "fecha" => "2007" "volumen" => "78" "numero" => "7 Suppl" "paginaInicial" => "1387" "paginaFinal" => "1399" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17608611" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Explaining phenotype heterogeneity in patients with psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Christophers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08307.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2008" "volumen" => "158" "paginaInicial" => "437" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18047519" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Host response mechanisms in periodontal diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Silva" 1 => "L. Abusleme" 2 => "D. Bravo" 3 => "N. Dutzan" 4 => "J. Garcia-Sesnich" 5 => "R. Vernal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/1678-775720140259" "Revista" => array:6 [ "tituloSerie" => "J Appl Oral Sci." "fecha" => "2015" "volumen" => "23" "paginaInicial" => "329" "paginaFinal" => "355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26221929" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical localization of CD1a and S100 in gingival tissues of healthy and chronic periodontitis subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Anjana" 1 => "L. Joseph" 2 => "R. Suresh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oral Dis." "fecha" => "2012" "volumen" => "18" "paginaInicial" => "778" "paginaFinal" => "785" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-22/IL-22R1 axis and S100A8/A9 alarmins in human osteoarthritic and rheumatoid arthritis synovial fibroblasts" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Carrion" 1 => "Y. Juarranz" 2 => "C. Martinez" 3 => "I. Gonzalez-Alvaro" 4 => "J.L. Pablos" 5 => "I. Gutierrez-Canas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/ket315" "Revista" => array:6 [ "tituloSerie" => "Rheumatology (Oxford)." "fecha" => "2013" "volumen" => "52" "paginaInicial" => "2177" "paginaFinal" => "2186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24056519" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Wilsmann-Theis" 1 => "J. Wagenpfeil" 2 => "D. Holzinger" 3 => "J. Roth" 4 => "S. Koch" 5 => "S. Schnautz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.13269" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2016" "volumen" => "30" "paginaInicial" => "1165" "paginaFinal" => "1170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26333514" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of proteins in human gingival crevicular fluid by mass spectrometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Kido" 1 => "M. Bando" 2 => "Y. Hiroshima" 3 => "H. Iwasaka" 4 => "K. Yamada" 5 => "N. Ohgami" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Periodontal Res." "fecha" => "2012" "volumen" => "47" "paginaInicial" => "488" "paginaFinal" => "499" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.C. Grevers" 1 => "T.J. de Vries" 2 => "T. Vogl" 3 => "S. Abdollahi-Roodsaz" 4 => "A.W. Sloetjes" 5 => "P.J. Leenen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.30290" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2011" "volumen" => "63" "paginaInicial" => "1365" "paginaFinal" => "1375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21337316" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanical stress induced S100A7 expression in human dental pulp cells to augment osteoclast differentiation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Charoenpong" 1 => "T. Osathanon" 2 => "P. Pavasant" 3 => "N. Limjeerajarus" 4 => "B. Keawprachum" 5 => "C.N. Limjeerajarus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/odi.13033" "Revista" => array:6 [ "tituloSerie" => "Oral Dis." "fecha" => "2019" "volumen" => "25" "paginaInicial" => "812" "paginaFinal" => "821" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30614184" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral fluid-based biomarkers in periodontal disease - part 2. Gingival crevicular fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. AlRowis" 1 => "H.S. AlMoharib" 2 => "A. AlMubarak" 3 => "J. Bhaskardoss" 4 => "R.S. Preethanath" 5 => "S. Anil" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Int Oral Health" "fecha" => "2014" "volumen" => "6" "paginaInicial" => "126" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25395809" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial “human osteoclastology”" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Kotake" 1 => "T. Yago" 2 => "M. Kawamoto" 3 => "Y. Nanke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00774-011-0321-5" "Revista" => array:7 [ "tituloSerie" => "J Bone Miner Metab" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "125" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21960179" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0738081X1200034X" "estado" => "S300" "issn" => "0738081X" ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-17 regulates the expressions of RANKL and OPG in human periodontal ligament cells via TRAF6/TBK1-JNK/NF-kappaB pathways" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Lin" 1 => "L. Li" 2 => "Y. Sun" 3 => "W. Wang" 4 => "X. Wang" 5 => "Y. Ye" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Immunology" "fecha" => "2015" "volumen" => "144" "paginaInicial" => "472" "paginaFinal" => "485" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Involvement of interleukin23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Ma" 1 => "D. Yang" 2 => "H. Okamura" 3 => "J. Teramachi" 4 => "T. Hasegawa" 5 => "L. Qiu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3892/mmr.2016.6041" "Revista" => array:6 [ "tituloSerie" => "Mol Med Rep." "fecha" => "2017" "volumen" => "15" "paginaInicial" => "559" "paginaFinal" => "566" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28000855" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.A. Awang" 1 => "D.F. Lappin" 2 => "A. MacPherson" 3 => "M. Riggio" 4 => "D. Robertson" 5 => "P. Hodge" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00011-014-0776-7" "Revista" => array:6 [ "tituloSerie" => "Inflamm Res" "fecha" => "2014" "volumen" => "63" "paginaInicial" => "1001" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25369802" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Sadeghi" 1 => "M. Sattari" 2 => "F. Dehghan" 3 => "S. Akbari" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5114/ceji.2018.74876" "Revista" => array:6 [ "tituloSerie" => "Cent Eur J Immunol." "fecha" => "2018" "volumen" => "43" "paginaInicial" => "76" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29736149" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association study between salivary levels of interferon (IFN)-gamma, interleukin (IL)-17, IL-21, and IL-22 with chronic periodontitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.M. Isaza-Guzman" 1 => "N. Cardona-Velez" 2 => "D.E. Gaviria-Correa" 3 => "M.C. Martinez-Pabon" 4 => "M.C. Castano-Granada" 5 => "S.I. Tobon-Arroyave" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.archoralbio.2014.09.002" "Revista" => array:6 [ "tituloSerie" => "Arch Oral Biol" "fecha" => "2015" "volumen" => "60" "paginaInicial" => "91" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25285903" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gingival crevicular fluid and interleukin-23 concentration in systemically healthy subjects: their relationship in periodontal health and disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.S. Himani" 1 => "M.L. Prabhuji" 2 => "B.V. Karthikeyan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jre.12100" "Revista" => array:6 [ "tituloSerie" => "J Periodontal Res." "fecha" => "2014" "volumen" => "49" "paginaInicial" => "237" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23721589" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Arican" 1 => "M. Aral" 2 => "S. Sasmaz" 3 => "P. Ciragil" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/MI.2005.273" "Revista" => array:6 [ "tituloSerie" => "Mediators Inflamm." "fecha" => "2005" "volumen" => "2005" "paginaInicial" => "273" "paginaFinal" => "279" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16258194" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Soderstrom" 1 => "G. Berstein" 2 => "W. Zhang" 3 => "H. Valdez" 4 => "L. Fitz" 5 => "M. Kuhn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1208/s12248-017-0094-4" "Revista" => array:6 [ "tituloSerie" => "AAPS J" "fecha" => "2017" "volumen" => "19" "paginaInicial" => "1218" "paginaFinal" => "1222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28534291" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Bissonnette" 1 => "J. Fuentes-Duculan" 2 => "S. Mashiko" 3 => "X. Li" 4 => "K.M. Bonifacio" 5 => "I. Cueto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdermsci.2016.09.019" "Revista" => array:6 [ "tituloSerie" => "J Dermatol Sci." "fecha" => "2017" "volumen" => "85" "paginaInicial" => "20" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27743912" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Gumus" 1 => "E. Buduneli" 2 => "B. Biyikoglu" 3 => "K. Aksu" 4 => "F. Sarac" 5 => "C. Nile" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1902/jop.2013.120595" "Revista" => array:6 [ "tituloSerie" => "J Periodontol." "fecha" => "2013" "volumen" => "84" "paginaInicial" => "1627" "paginaFinal" => "1637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23327689" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.G. de Aquino" 1 => "S. Abdollahi-Roodsaz" 2 => "M.I. Koenders" 3 => "F.A. van de Loo" 4 => "G.J. Pruijn" 5 => "R.J. Marijnissen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Immunol" "fecha" => "2014" "volumen" => "192" "paginaInicial" => "4103" "paginaFinal" => "4111" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Periodontitis increases rheumatic factor serum levels and citrullinated proteins in gingival tissues and alter cytokine balance in arthritic rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.G. Correa" 1 => "S.B. Sacchetti" 2 => "F.V. Ribeiro" 3 => "S.P. Pimentel" 4 => "R.C. Casarin" 5 => "F.R. Cirano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0189910" "Revista" => array:4 [ "tituloSerie" => "PLoS One" "fecha" => "2017" "volumen" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29287100" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis-like skin lesions are dependent on IL-23 but develop in the absence of IL-22 in a model mouse" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Takaishi" 1 => "K. Nakajima" 2 => "W. Ouyang" 3 => "S. Sano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdermsci.2013.11.008" "Revista" => array:6 [ "tituloSerie" => "J Dermatol Sci" "fecha" => "2014" "volumen" => "73" "paginaInicial" => "261" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24315761" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.B. Van Belle" 1 => "M. de Heusch" 2 => "M.M. Lemaire" 3 => "E. Hendrickx" 4 => "G. Warnier" 5 => "K. Dunussi-Joannopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Immunol." "fecha" => "2012" "volumen" => "188" "paginaInicial" => "462" "paginaFinal" => "469" ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation of IL-12, IL-22, and IL-23 in patients with psoriasis and metabolic syndrome. Preliminary report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Brito-Luna" 1 => "D.G. Villanueva-Quintero" 2 => "A.K. Sandoval-Talamantes" 3 => "M. Fafutis-Morris" 4 => "O. Graciano-Machuca" 5 => "P.E. Sanchez-Hernandez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cyto.2016.06.020" "Revista" => array:6 [ "tituloSerie" => "Cytokine" "fecha" => "2016" "volumen" => "85" "paginaInicial" => "130" "paginaFinal" => "136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27344023" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.M. Cordoro" 1 => "M. Hitraya-Low" 2 => "K. Taravati" 3 => "P.M. Sandoval" 4 => "E. Kim" 5 => "J. Sugarman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2017.05.017" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2017" "volumen" => "77" "paginaInicial" => "417" "paginaFinal" => "424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28624119" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of the Expression Profile of JunB, c-Jun, and S100A8 (Calgranulin A) in Psoriasis Vulgaris and Guttate Psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.C. Park" 1 => "K.J. Kim" 2 => "S.Y. Woo" 3 => "J.H. Chun" 4 => "K.H. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5021/ad.2009.21.1.35" "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol." "fecha" => "2009" "volumen" => "21" "paginaInicial" => "35" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20548852" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000015/v2_202104300920/en/main.assets" "Apartado" => array:4 [ "identificador" => "89516" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000002/v2_202104300920/S0365059621000015/v2_202104300920/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000015?idApp=UINPBA00008Z"]

Estatísticas

Original Article

Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis

Constanza Jiméneza, Daniela Carvajalb, Marcela Hernándezc,d, Fernando Valenzuelab, Jessica Astorgac, Alejandra Fernándeza,c,

Autor para correspondência

alejandra.fernandez@unab.cl

Corresponding author.

a Department of Oral Pathology, Faculty of Dentistry, Universidad Andrés Bello, Santiago, Chile

b Department of Dermatology, Faculty of Medicine, Universidad de Chile, Santiago, Chile

c Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago, Chile

d Department of Oral Pathology and Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, Chile

Lido

7312

Vezes
que se leu este artigo

3249

Total PDF

4063

Total HTML

Compartilhar estatísticas

 array:24 [
  "pii" => "S0365059621000015"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2020.08.008"
  "estado" => "S300"
  "fechaPublicacion" => "2021-03-01"
  "aid" => "302"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2021"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "fla"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275221000011"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2021.02.001"
      "estado" => "S300"
      "fechaPublicacion" => "2021-03-01"
      "aid" => "302"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "fla"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Artigo original</span>"
        "titulo" => "N&#237;veis das interleucinas 17A&#44; 22 e 23 e da fam&#237;lia de prote&#237;nas S100 no fluido gengival crevicular de pacientes psori&#225;sicos com ou sem periodontite"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "tieneResumen" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "163"
            "paginaFinal" => "170"
          ]
        ]
        "contieneResumen" => array:1 [
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 3506
                "Ancho" => 1250
                "Tamanyo" => 181592
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Concentra&#231;&#227;o de IL&#8208;17&#44; IL&#8208;22 e IL&#8208;23 no FCG dos indiv&#237;duos do estudo&#46; <span class="elsevierStyleItalic">H</span>&#44; controle saud&#225;vel&#59; <span class="elsevierStyleItalic">P</span>&#44; indiv&#237;duos com periodontite n&#227;o tratada&#59; <span class="elsevierStyleItalic">S</span>&#44; indiv&#237;duos com psor&#237;ase n&#227;o tratada&#59; <span class="elsevierStyleItalic">SP</span>&#44; indiv&#237;duos com psor&#237;ase n&#227;o tratada e periodontite n&#227;o tratada&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Constanza Jim&#233;nez, Daniela Carvajal, Marcela Hern&#225;ndez, Fernando Valenzuela, Jessica Astorga, Alejandra Fern&#225;ndez"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Constanza"
                "apellidos" => "Jim&#233;nez"
              ]
              1 => array:2 [
                "nombre" => "Daniela"
                "apellidos" => "Carvajal"
              ]
              2 => array:2 [
                "nombre" => "Marcela"
                "apellidos" => "Hern&#225;ndez"
              ]
              3 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Valenzuela"
              ]
              4 => array:2 [
                "nombre" => "Jessica"
                "apellidos" => "Astorga"
              ]
              5 => array:2 [
                "nombre" => "Alejandra"
                "apellidos" => "Fern&#225;ndez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059621000015"
          "doi" => "10.1016/j.abd.2020.08.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000015?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000011?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009600000002/v2_202104230742/S2666275221000011/v2_202104230742/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059621000064"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.09.002"
    "estado" => "S300"
    "fechaPublicacion" => "2021-03-01"
    "aid" => "307"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Prolonged luteal phase support with progesterone may increase papules and plaques of pregnancy frequency in pregnancies through <span class="elsevierStyleItalic">in vitro</span> fertilization"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "171"
          "paginaFinal" => "175"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Nur Dokuzeylul Gungor, Tugba Gurbuz, Tugba Ture"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Nur"
              "apellidos" => "Dokuzeylul Gungor"
            ]
            1 => array:2 [
              "nombre" => "Tugba"
              "apellidos" => "Gurbuz"
            ]
            2 => array:2 [
              "nombre" => "Tugba"
              "apellidos" => "Ture"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275221000060"
        "doi" => "10.1016/j.abdp.2020.09.020"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000060?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000064?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000064/v2_202104300920/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S036505962100012X"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.05.015"
    "estado" => "S300"
    "fechaPublicacion" => "2021-03-01"
    "aid" => "313"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Gene panel for the diagnosis of epidermolysis bullosa&#58; proposal for a viable and efficient approach"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "155"
          "paginaFinal" => "162"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2038
              "Ancho" => 2175
              "Tamanyo" => 316531
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gene panel as the first choice for the diagnosis of EB&#58; main characteristics&#46; Gene panel has high efficiency and precision&#44; a price comparable to other EB diagnostic methods&#44; and eliminates the need for skin biopsy&#46; The cost of NGS technology has been decreasing&#44; which indicates that the gene panel should become more accessible in the coming years&#46; Identification of the genetic alteration allows establishing disease prognosis&#44; prenatal and pre-implantation genetic diagnosis&#44; has implications for genetic counseling&#44; and is important for the development of future therapies for EB&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luiza Monteavaro Mariath, Ana Elisa Kiszewski, Jeanine Aparecida Frantz, Marina Siebert, Ursula Matte, Lav&#237;nia Schuler-Faccini"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Luiza Monteavaro"
              "apellidos" => "Mariath"
            ]
            1 => array:2 [
              "nombre" => "Ana Elisa"
              "apellidos" => "Kiszewski"
            ]
            2 => array:2 [
              "nombre" => "Jeanine Aparecida"
              "apellidos" => "Frantz"
            ]
            3 => array:2 [
              "nombre" => "Marina"
              "apellidos" => "Siebert"
            ]
            4 => array:2 [
              "nombre" => "Ursula"
              "apellidos" => "Matte"
            ]
            5 => array:2 [
              "nombre" => "Lav&#237;nia"
              "apellidos" => "Schuler-Faccini"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275221000126"
        "doi" => "10.1016/j.abdp.2020.05.031"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000126?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962100012X?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009600000002/v2_202104300920/S036505962100012X/v2_202104300920/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Levels of the interleukins 17A&#44; 22&#44; and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "163"
        "paginaFinal" => "170"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Constanza Jim&#233;nez, Daniela Carvajal, Marcela Hern&#225;ndez, Fernando Valenzuela, Jessica Astorga, Alejandra Fern&#225;ndez"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "Constanza"
            "apellidos" => "Jim&#233;nez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Daniela"
            "apellidos" => "Carvajal"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Marcela"
            "apellidos" => "Hern&#225;ndez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Fernando"
            "apellidos" => "Valenzuela"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Jessica"
            "apellidos" => "Astorga"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:4 [
            "nombre" => "Alejandra"
            "apellidos" => "Fern&#225;ndez"
            "email" => array:1 [
              0 => "alejandra.fernandez@unab.cl"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Department of Oral Pathology&#44; Faculty of Dentistry&#44; Universidad Andr&#233;s Bello&#44; Santiago&#44; Chile"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Dermatology&#44; Faculty of Medicine&#44; Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Laboratory of Periodontal Biology&#44; Faculty of Dentistry&#44; Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Department of Oral Pathology and Medicine&#44; Faculty of Dentistry&#44; Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2317
            "Ancho" => 1250
            "Tamanyo" => 106195
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Concentration of S100A7 and S100A8 in GCF of study individuals&#46; Bars and asterisk represent p&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Psoriasis is a chronic immunologically mediated inflammatory dermatosis and recurrent autoimmune disease that occurs in genetically susceptible individuals&#46; Psoriasis is common&#59; its prevalence is about 2&#37; in Europe and North America&#46; The main clinical skin manifestations include itching&#44; burning&#44; and soreness&#44; accompanied by the development of well-defined&#44; scaly&#44; erythematous plaque lesions resulting from abnormal proliferation and differentiation of keratinocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The pathogenesis of psoriasis remains unclear&#59; however&#44; interactions between keratinocytes and resident skin T cells within the interleukin &#40;IL&#41; 23&#47;Th17 pathway appear to participate in the onset and progression of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Evidence supporting this hypothesis includes the isolation of IL-23 and IL-17 mRNA from psoriatic skin lesions and the report of increased serum concentrations of IL-17A&#44; IL-22&#44; and IL-23 in psoriatic patients <span class="elsevierStyleItalic">vs&#46;</span> healthy controls&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;5</span></a> In recent years&#44; special attention has been given to the prospective role of S100 proteins in the development of psoriasis&#46; The S100 protein family is composed of calcium-binding proteins&#44; in which psoriasin &#40;S100A7&#41; and calgranulin A &#40;S100A8&#41; are regulated by IL-17&#44; amplifying the inflammatory response&#46; S100A7&#44; S100A8&#44; and calgranulin B &#40;S100A9&#41; have been reported to express in psoriatic skin-lesions revealing these S100 proteins could play a key role in the unregulated growth and differentiation of keratinocytes in the skin of psoriatic patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;9</span></a> Additionally&#44; it has been indicated S100 proteins act as a chemotactic factors for immune cells&#44; inducing a pro-inflammatory environment in which the onset and recurrence of psoriasis may easily occur&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Recently&#44; epidemiological studies have associated psoriasis with periodontitis&#44; suggesting a common underlying immunopathogenesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;11</span></a> Although studies on the subject are scarce&#44; results are particularly interesting since a potentially bidirectional relationship between the two diseases has been suggested&#46; In these studies&#44; psoriatic patients not only presented a higher frequency of periodontitis and worse periodontal parameters&#44; but also an increased risk of developing periodontitis compared to non-psoriatic healthy controls&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#8211;14</span></a> Furthermore&#44; a potential dose-response relationship between psoriasis and periodontitis was reported by Egeberg et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> as the frequency of periodontitis increased when the severity of the psoriasis augmented&#46; Some evidence indicates periodontal patients might have an increased frequency and risk of psoriasis&#59; nonetheless&#44; more evidence is still needed&#46; In the same line as psoriasis&#44; the pathogenesis of periodontitis includes a special involvement of the IL-23&#47;Th17 pathway&#46; The expression of IL-17&#44; IL-22&#44; and IL-23 has been evaluated in the gingival crevicular fluid &#40;GCF&#41; of patients with chronic periodontitis&#44; and these cytokines have been associated with the pathogenesis and severity of the disease and alveolar bone resorption&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a> In periodontitis&#44; studies have detected a S100A8&#47;S100A9 heterocomplex in GCF&#44; saliva&#44; and serum of patients with periodontitis&#44; whereas a recent study associated periodontitis with elevated levels of salivary S100A8&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#8211;21</span></a> To date&#44; there has been no evidence to evaluate the expression of IL-23&#47;Th17-related cytokines and S100-family proteins in the GCF of psoriatic patients&#46; Due to GCF comprising diagnosis biomarkers of oral and systemic diseases as well as accurately exposing the constituents of serum and the cellular reactions of the periodontium&#44; it is hypothesized that the levels of cytokines involved in T-cell regulation and S100 protein family molecules in GCF will show marked differences in psoriatic and healthy individuals with or without periodontitis&#44; reflecting the link between psoriasis and periodontitis&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Hence&#44; the aim of this study was to evaluate the levels of IL-17A&#44; IL-22&#44; IL-23&#44; S100A7&#44; S100A8&#44; and S100A9 in GCF of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The present cross-sectional study was approved by the bioethics committee of the North Metropolitan Health Service&#44; Santiago&#44; Chile &#40;N52&#47;2017&#41;&#46; All participants provided written informed consent prior to study enrollment&#44; in accordance with the Helsinki Declaration&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Selection of patients</span><p id="par0025" class="elsevierStylePara elsevierViewall">Individuals referred for presumed diagnosis of psoriasis to the dermatology unit of San Jos&#233; Hospital&#44; Santiago&#44; Chile&#44; were enrolled over a ten-month period &#40;2018&#41;&#46; Individuals without psoriasis were simultaneously selected from volunteering patients attending the dental clinic of the Faculty of Dentistry of Andres Bello University&#44; Santiago&#44; Chile&#46; Global eligibility criteria included the following&#58; I&#41; adult patients &#40;&#8805; 18 years&#41; with II&#41; eleven or more teeth &#40;excluding third molars&#41;&#46; Exclusion criteria were set as follows&#58; I&#41; individuals with any known systemic disorders&#47;conditions other than psoriasis &#40;especially those involving inflammatory&#47;immune dysregulation such as diabetes&#44; systemic lupus&#44; and arthritis&#47;osteoarthritis&#44; among others&#41;&#44; II&#41; patients who had received antibiotic&#44; nonsteroidal anti-inflammatory&#44; and&#47;or immunomodulatory therapy in the last three months&#44; III&#41; patients who had undergone radiotherapy and&#47;or chemotherapy in the last year&#44; and IV&#41; patients who had received periodontal or&#47;and psoriasis treatment in the last six months&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Clinical measurements</span><p id="par0030" class="elsevierStylePara elsevierViewall">All patients were evaluated by the same team of experts&#46; Dermatological data were collected from the initial consultation by dermatologists from the hospital staff&#46; Clinical confounder variables evaluated included sex and age&#46; Clinical psoriasis variables included presence or absence of psoriasis&#44; clinical type of psoriasis&#44; and psoriasis severity&#44; defined by the &#40;a&#41; Psoriasis Area and Severity Index &#40;PASI&#41;&#44; &#40;b&#41; body surface area &#40;BSA&#41;&#44; the &#40;c&#41; static Physician&#8217;s Global Assessment &#40;PGA&#41;&#44; and the Dermatology Life Quality Index &#40;DLQI&#41;&#46; Periodontal evaluation and sampling were performed by a qualified periodontist&#46; Clinical periodontal evaluation included full-mouth manual periodontal charting &#40;six sites per tooth&#44; excluding third molars&#41; and recording of the following parameters&#58; probing depth &#40;PD&#41;&#44; clinical attachment level &#40;CAL&#41;&#44; bleeding on probing &#40;BOP&#41;&#44; and tooth loss&#46; Additional information regarding oral hygiene habits and smoking were collected&#46; Periodontal status was defined according to the clinical case definition of periodontitis proposed by the Centers for Disease Control and Prevention &#40;CDC&#41;&#44; United States&#46; Severe periodontitis was defined as two or more interproximal sites with CAL<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mm &#40;not on the same tooth&#41; and &#8805; 1 interproximal site with PD<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm&#46; Moderate periodontitis was defined as two or more interproximal sites with CAL<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>mm &#40;not on the same tooth&#41; and&#47;or two or more interproximal sites with PD<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm&#46; Finally&#44; no&#47;mild cases of periodontitis were defined as neither severe nor moderate periodontitis&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">From a total of 93 individuals evaluated&#44; 82 met the inclusion criteria&#46; Subjects were divided into the following groups&#58; H&#44; systemically healthy controls with no&#47;mild periodontitis&#59; P&#44; systemically healthy controls with moderate&#47;severe periodontitis&#59; S&#44; individuals with psoriasis with no&#47;mild periodontitis&#59; and SP&#44; individuals with psoriasis and moderate&#47;severe periodontitis&#46; Finally&#44; from an ethical standpoint&#44; it must be noted that all patients examined in this study with a positive diagnosis for either psoriasis and&#47;or periodontitis were referred for timely treatment at San Jos&#233; Hospital and&#47;or the dental clinic of Andres Bello University&#44; respectively&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Gingival crevicular fluid &#40;GCF&#41; collection</span><p id="par0040" class="elsevierStylePara elsevierViewall">Samples were obtained from four independent sites based on probing depth&#44; deepest site per quadrant&#46; Before sampling&#44; sites were isolated with cotton rolls and then carefully dried with an air-syringe to prevent saliva contamination&#46; GCF was collected using sterile periodontal strips &#40;Periopaper&#174;&#59; Interstate Drug Exchange &#8211; Amityville&#44; NY&#44; United States&#41; gently inserted into the gingival sulcus or pocket until mild resistance was noticed&#46; After 30 seconds&#44; strips were collected into sterile tubes and immediately transported to the laboratory for storage &#40;&#8722;20<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; and posterior analysis&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">GCF analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">A 40<span class="elsevierStyleHsp" style=""></span>&#956;L elution&#47;strip was prepared using protein elution buffer into sterile tubes&#46; Samples were incubated for half an hour at 4<span class="elsevierStyleHsp" style=""></span>&#176;C and then centrifuged at 12&#44;000 &#215; g for five minutes at 4<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; The procedure was repeated twice&#44; and samples were frozen and kept at &#8722;20<span class="elsevierStyleHsp" style=""></span>&#176;C until analysis&#46; Aliquots from all GCF samples were used for protein quantification using a multiplex assay panel &#40;Human Magnetic Luminex Assay&#174;&#59; R&#38;D Systems &#8211; MN&#44; United States&#41; for Il-17A&#44; Il-22&#44; IL-23&#44; S100A8&#44; and S100A9&#44; and an ELISA Kit &#40;Human Protein S100-A7 Elisa Kit&#174;&#59; MyBioSource Inc &#8211; San Diego&#44; CA&#44; United States&#41; for S100A7&#44; according to the manufacturers&#8217; instructions&#46; Data from the multiplex analysis panel were read using a platform &#40;Magpix&#59; Millipore &#8211; St&#46; Charles&#44; MO&#44; United States&#41; and then analyzed using software &#40;MILLIPLEX AnalystR&#59; Viagene Tech &#8211; Carlisle&#44; MA&#44; United States&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">The Shapiro-Wilk test and Levene&#8217;s test were used to determine the distribution and homoscedasticity of the data&#44; respectively&#46; Inferential analyses were performed with Fisher&#8217;s exact test&#44; analysis of variance &#40;ANOVA&#41;&#44; and Duncan&#8217;s post hoc test&#46; An ANOVA model type III was applied with a covariate&#58; the age of the subjects examined&#46; The correlation coefficients were obtained using Spearman&#8217;s correlation analysis&#46; The level of significance was defined as p <span class="elsevierStyleItalic">&#60;</span> 0&#46;05&#46; The effect size &#40;eta-squared&#41; was calculated&#44; shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The statistical analysis was performed using a statistical software &#40;STATA 12&#174;&#59; StataCorp &#8211; College Station&#44; TX&#44; United States&#41;&#46; It must be noted that as a result of the explorative nature of this research&#44; no sample-size calculation was performed&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">In total&#44; 82 individuals were included in this study&#58; 21 controls with no&#47;mild periodontitis &#40;H&#41;&#44; 18 controls with moderate&#47;severe periodontitis &#40;P&#41;&#44; 11 individuals with psoriasis and no&#47;mild periodontitis &#40;S&#41;&#44; and 32 individuals with psoriasis and moderate&#47;severe periodontitis &#40;SP&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Demographic data&#44; habits&#44; and clinical parameters of all individuals in this study are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; No significant differences among groups regarding gender&#44; smoking&#44; BOP&#44; and oral hygiene habits&#44; PASI&#44; BSA&#44; PGA&#44; and DLQI were found&#46; The highest mean age was found in the SP group&#44; followed by groups P&#44; S&#44; and H in decreasing order&#46; Only the SP group showed significant differences in mean age with group H &#40;p <span class="elsevierStyleItalic">&#60;</span> 0&#46;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Regarding periodontal clinical parameters&#44; PD was significantly worse&#47;deeper in the SP group compared to groups S&#44; P&#44; and H &#40;p <span class="elsevierStyleItalic">&#60;</span> 0&#46;05&#41;&#46; The P group presented significantly deeper pockets than the H group &#40;p <span class="elsevierStyleItalic">&#60;</span> 0&#46;05&#41;&#46; The highest CAL was observed in the SP group compared to that for groups S&#44; P&#44; and H &#40;p <span class="elsevierStyleItalic">&#60;</span> 0&#46;05&#41;&#46; The highest tooth loss was observed in the SP group&#44; followed by groups S&#44; P&#44; and H in decreasing order&#46; Regarding dermatological clinical data&#44; no significant differences in PASI&#44; BSA&#44; and PGA were found between groups S and SP&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The concentrations of IL-17A&#44; IL-22&#44; and IL-23 in the GCF are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; No intergroup differences regarding the levels of IL-17A&#44; IL-22&#44; and IL-23 in GCF were noted&#46; The GCF levels of IL-17A&#44; IL-22&#44; and IL-23 in the SP group showed a tendency to be higher than those of the S group&#44; respectively&#46; GCF concentrations of S100A7 and S100A8 in the different groups are presented in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46; No significant differences in the levels of S100A7 in the GCF of the different groups were observed&#46; Group H presented the lowest levels of S100A8 compared to the S and SP groups &#40;p <span class="elsevierStyleItalic">&#60;</span> 0&#46;05&#41;&#46; Additionally&#44; group P presented lower levels of S100A8 compared to the S and SP groups &#40;p <span class="elsevierStyleItalic">&#60;</span> 0&#46;05&#41;&#46; Nevertheless&#44; age demonstrated no influence upon the concentration of all interleukins and the S100 protein family &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Concentrations of S100A9 in the GCF of all groups exceeded the upper-detection limits of the ELISA kit&#59; therefore&#44; exact quantification and analysis were not possible&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The levels of inflammatory mediators in GCF were correlated with the periodontal clinical parameters in group H and group P&#46; In group H&#44; IL-17A levels were negatively correlated with CAL &#40;-0&#46;499&#41;&#44; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; In group P&#44; IL-22 was positively correlated with PD &#40;0&#46;490&#41; and CAL &#40;0&#46;589&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; In groups S and SP&#44; correlations between inflammatory mediators and both periodontal and dermatological clinical parameters were obtained&#46; In the S group&#44; IL-23 was negatively correlated with PGA&#44; whereas S100A8 was positively and strongly correlated with PASI &#40;0&#46;878&#41;&#44; BSA &#40;0&#46;851&#41;&#44; and DLQI &#40;0&#46;622&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; In the SP group&#44; IL-22 and IL-23 were negatively correlated with BSA &#40;-0&#46;358 and -0&#46;468&#44; respectively&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">Psoriasis and periodontitis share similar mechanisms of immune dysregulation&#44; characterized by a Th17 axis-predominant immune response&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> The Th17 pathway regulates the expression of S100 proteins&#44; which may participate in the pathogenesis of both diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#8211;28</span></a> In the present study&#44; elevated levels of S100A8 were found in the GCF of psoriatic patients compared to that of systemically healthy controls&#44; regardless of their periodontal health&#47;status&#59; there was a strong positive correlation between S100A8 with BSA&#44; PASI&#44; and DLQI in the psoriasis group &#40;group S&#41;&#44; suggesting that GCF concentrations of S100A8 could be a promising non-invasive biomarker for the presence and severity of psoriasis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">To the best of the authors&#8217; knowledge&#44; no previous studies have evaluated the GCF concentrations of S100A7 and S100A8 in psoriatic individuals with or without periodontitis&#46; In periodontitis alone&#44; S100A7 and S100A8 have been detected in the GCF of individuals with periodontitis using the techniques of mass spectrometry and western blot&#44; indicating these molecules might participate in the immune response of periodontal tissues&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> In addition&#44; S100A7 and S100A8 could be involved in periodontal bone resorption&#44; as evidence shows S100A8 induced osteoclastic bone resorption in experimental arthritis 30 and S100A7 stimulated osteoclast differentiation in human monocytes in vitro&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a> Recently&#44; Karna et al&#46; reported and associated increased levels of salivary S100A8 with periodontitis in Korean adults&#44; suggesting salivary concentrations of S100A8 could be a prospective biomarker for periodontitis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> In psoriasis&#44; S100A7 has been reported to induce unregulated differentiation of the epidermis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> It is thought that S100A7 functions as a keratinocyte-derived chemotactic agent for immune cells&#44; as a result the molecule strongly attracts CD4&#43; lymphocytes and neutrophils under inflammatory stress&#46; S100A8 and S100A9 molecules are initially released from keratinocytes to start&#47;prompt immune cell invasion&#44; which is further sustained by the later release of the same molecules from incoming neutrophils&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> The detection of different S100 family proteins in serum has been proposed as prospective biomarker for psoriasis&#44; as increased levels of S100A7 and S100A8 have been detected in blood samples of untreated psoriatic patients compared with non-psoriatic healthy individuals&#46; Moreover&#44; gene expression of S100A7 and S100A8 in psoriatic skin lesions has been reported to be significantly higher than that of healthy skin samples&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The present findings show S100A8 presents in higher concentrations in the GCF of psoriatic patients <span class="elsevierStyleItalic">vs&#46;</span> non-psoriatic healthy controls&#44; regardless of their periodontal health&#47;status&#46; Nonetheless&#44; the concentrations of S100A7 between groups presented no differences&#46; Therefore&#44; in line with previously reported evidence&#44; these results suggest that S100A8 may be a key protein involved in the pathogenesis of psoriasis&#46; In addition&#44; it is believed that S100A8 could reflect the presence and severity of psoriasis&#44; thus presenting as a promising&#44; safe&#44; non-invasive biomarker for early diagnosis of the disease regardless of periodontal health&#46; Increased levels of S100A8 in the GCF samples of psoriatic subjects might be explained by the systemic dissemination of the molecules from active psoriatic skin lesions&#58; It is possible that active psoriatic skin lesions may function as local spots for the massive production of S100A8&#44; which then enters the blood stream <span class="elsevierStyleItalic">via</span> increased vascular permeability and travels to distant sites&#44; such as the oral gingiva&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">The present study observed that overall concentrations of IL-17A&#44; IL-22&#44; and IL-23 presented a tendency to increase in psoriatic patients with moderate&#47;severe periodontitis &#40;group SP&#41; compared to psoriatic patients with no&#47;mild periodontitis &#40;group S&#41;&#46; These findings could be attributed to a local effect of periodontitis&#46; According to the literature&#44; IL-17&#44; IL-22&#44; and IL-23 are associated with osteoclastogenesis in periodontitis&#59; however&#44; their concentrations within the oral fluids of periodontal patients remains controversial&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;33&#8211;35</span></a> In one study&#44; IL-17A levels in serum&#44; saliva&#44; and GCF were higher in periodontitis than in healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> In contrast&#44; another study reported higher levels of IL-17 in the GCF of healthy individuals than in subjects with either chronic or aggressive periodontitis&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> In relation to IL-22&#44; a previous study reported no differences in the saliva concentrations of IL-22 of individuals with chronic periodontitis <span class="elsevierStyleItalic">vs&#46;</span> healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> However&#44; an additional study reported higher levels of IL-22 in the GCF of subjects with periodontitis compared with those of subjects with gingivitis and healthy individuals 17&#46; Regarding IL-23&#44; a study reported higher concentrations of the molecule in the GCF of patients with chronic periodontitis <span class="elsevierStyleItalic">vs&#46;</span> healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> In contrast&#44; R&#46; Sadeghi et al&#46; reported higher concentrations of IL-23 in the GCF of healthy subjects compared to patients with chronic periodontitis&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> It is theorized that these discrepancies may be due to differences in the methods used to quantify the concentrations of the above-mentioned proteins&#44; as well as the absence of consensus regarding clinical case definitions of periodontitis&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Previously&#44; the detection of IL-17 in the serum and skin of patients with psoriasis has been reported&#44; while not in GCF&#46; Differences in the concentration of IL-17 in serum samples of psoriatic patients <span class="elsevierStyleItalic">vs</span>&#46; those of healthy controls is controversial&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;40&#44;41</span></a> However&#44; skin psoriatic biopsies have shown higher expression of IL-17A than those of healthy subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> Differences between the present results and those previously reported in the literature may be due to the different time points in the history of psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> There are no previous studies reporting the presence of IL-17 in the GCF of individuals with psoriasis with or without periodontitis&#59; however&#44; higher levels of IL-17A have been detected in the GCF of individuals with other autoimmune diseases and periodontitis&#46; Such is the case of rheumatoid arthritis patients with periodontitis&#44; who have presented higher levels of IL-17A than those of systemically healthy subjects with periodontal disease&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> In addition&#44; an experimental animal study has shown an increase in IL-17 production by lymph node T-cells in arthritic mice with periodontitis compared with that in arthritic mice without periodontitis&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> Another study showed that periodontitis seems to alter IL-17 levels in gingival tissue samples of arthritic rats&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Regarding psoriasis&#44; it has been reported that IL-22 and IL-23 are required to induce psoriasis-like lesions in animal models&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">46&#44;47</span></a> Similarly to the present results&#44; some studies have reported no differences in the levels of IL-22 and IL-23 in the serum of patients with psoriasis <span class="elsevierStyleItalic">vs&#46;</span> those of healthy controls&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#44;49</span></a> However&#44; only one study reported increased concentrations of IL-22 and IL-23 in the serum of psoriatic patients <span class="elsevierStyleItalic">vs&#46;</span> those of non-psoriatic healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> These findings suggest that IL-22 and IL-23 may act preferentially at a local level in psoriasis&#46; All these antecedents support the potential role of periodontitis in the tendency to increased levels of IL-17&#44; IL-22&#44; and IL-23 in the SP group compared to the S group shown in the present study&#46; In this study&#44; the no&#47;mild cases of periodontitis within groups H and S could have partially masked the net differences between healthy non-periodontal controls and periodontal patients&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Regarding the correlations between GCF inflammatory mediators and periodontal disease&#44; it was found that group H had a negative correlation between the levels of IL-17A and CAL&#44; whereas group P had a positive correlation between IL-22 and PD and CAL&#46; These findings suggest that these inflammatory mediators participate in periodontal disease pathogenesis&#44; which has been previously suggested in the literature&#44; as both interleukins have been linked to osteoclastogenesis in periodontal disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;35</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Although the IL-23&#47;Th17 pathway is part of cutaneous inflammation in psoriasis&#44; a negative correlation was detected between IL-23 and PGA in group S&#46; In addition&#44; a negative correlation was found between IL-22 and IL-23 in group SP&#46; This result could be explained by the diverging phenotype in psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> To the authors&#8217; knowledge&#44; this study is the first article to report that GCF levels of S100A8 correlate positively with BSA&#44; PASI&#44; and DLQI in individuals with psoriasis&#44; suggesting that S100A8 in GCF may serve as a potential biomarker of presence and severity of psoriasis&#46; This may be justified by the high expression of S100A8 in the epidermis of psoriatic skin&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">This pilot study presents a small sample size&#44; which the authors acknowledge as a limitation&#46; Nonetheless&#44; the number of individuals included allowed for the identification of changes in the GCF of individuals with and without psoriasis&#46; Therefore&#44; more studies are essential to elucidate the potential link between periodontitis and psoriasis&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0125" class="elsevierStylePara elsevierViewall">The concentrations of S100A8 were highest in the GCF of psoriatic patients regardless of their periodontal health&#47;status&#46; Furthermore&#44; S100A8 in GCF was associated with the severity of psoriasis&#46; The concentrations of interleukins and S100A7 were similar in GCF of psoriatic patients with or without periodontitis in relation to healthy controls&#46; Therefore&#44; the immune molecules evaluated in GCF in the present study do not seem to reflect the link between periodontitis and psoriasis&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financial support</span><p id="par0130" class="elsevierStylePara elsevierViewall">This research was supported by a grant from <span class="elsevierStyleGrantSponsor" id="gs0005">Direcci&#243;n General de Investigaci&#243;n de la Universidad Andr&#233;s Bello</span> &#40;DGI-UNAB&#41;&#44; No&#46; DI-36-18&#47;CBC&#44; and <span class="elsevierStyleGrantSponsor" id="gs0010">FONDECYT</span>&#44; No&#46; 1160741&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Authors&#39; contributions</span><p id="par0135" class="elsevierStylePara elsevierViewall">Constanza Jim&#233;nez&#58; Approval of the final version of the manuscript&#59; study conception and planning&#59; preparation and writing of the manuscript&#59; data collection&#44; analysis&#44; and interpretation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Daniela Carvajal&#58; Approval of the final version of the manuscript&#59; preparation and writing of the manuscript&#59; data collection&#44; analysis&#44; and interpretation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Marcela Hern&#225;ndez&#58; Approval of the final version of the manuscript&#59; study conception and planning&#59; preparation and writing of the manuscript&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Fernando Valenzuela&#58; Approval of the final version of the manuscript&#59; study conception and planning&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Jessica Astorga&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the manuscript&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Alejandra Fern&#225;ndez&#58; Approval of the final version of the manuscript&#59; study conception and planning&#59; preparation and writing of the manuscript&#59; data collection&#44; analysis&#44; and interpretation&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicts of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres1505251"
          "titulo" => "Abstract"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objective"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Methods"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Results"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Study limitations"
            ]
            5 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1366007"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        3 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Selection of patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Clinical measurements"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Gingival crevicular fluid &#40;GCF&#41; collection"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "GCF analysis"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Results"
        ]
        5 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Discussion"
        ]
        6 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conclusions"
        ]
        7 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Financial support"
        ]
        8 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Authors&#39; contributions"
        ]
        9 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflicts of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-12-19"
    "fechaAceptado" => "2020-08-04"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1366007"
          "palabras" => array:4 [
            0 => "Cytokinesis"
            1 => "Periodontal diseases"
            2 => "Psoriasis"
            3 => "S100 proteins"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases&#46; Epidemiologic evidence has linked both&#59; however&#44; the change of markers in gingival crevicular fluid has been poorly evaluated&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">To evaluate the levels of IL-17A&#44; IL-22&#44; IL-23&#44; S100A7&#44; S100A8&#44; and S100A9 in gingival crevicular fluid of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study&#46; Sample comprised the following groups&#58; healthy controls without periodontitis or with mild periodontitis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&#41;&#44; healthy controls with moderate or severe periodontitis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#41;&#44; individuals with psoriasis without or mild periodontitis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41;&#44; and individuals with psoriasis and moderate or severe periodontitis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#41;&#46; Levels of IL-17A&#44; IL-22&#44; IL-23&#44; S100A8&#44; and S100A9 were determined by multiplex assay and S100A7 was measured by ELISA&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">No inter-group differences in the levels of IL-17A&#44; IL-22&#44; IL-23&#44; and S100A7 were found&#46; S100A8 levels were higher in psoriatic patients than controls &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; S100A8 was positively correlated with psoriasis severity in the group with psoriasis &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; S100A9 exceeded the detection limits&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Study limitations</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">This pilot study presents a small sample size&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The concentrations of S100A8 were highest in psoriatic patients regardless of periodontal health&#47;status&#46; S100A8 was associated with the severity of psoriasis&#46; The concentrations of interleukins and S100A7 were similar in psoriatic patients with or without periodontitis <span class="elsevierStyleItalic">vs&#46;</span> healthy controls&#46;</p></span>"
        "secciones" => array:6 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Study limitations"
          ]
          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Jim&#233;nez C&#44; Carvajal D&#44; Hern&#225;ndez M&#44; Valenzuela F&#44; Astorga J&#44; Fern&#225;ndez A&#46; Levels of the interleukins 17A&#44; 22&#44; and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis&#46; An Bras Dermatol&#46; 2021&#59;96&#58;163&#8211;70&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Universidad Andr&#233;s Bello and Universidad de Chile&#44; Hospital San Jose&#44; Santiago&#44; Chile&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 3506
            "Ancho" => 1250
            "Tamanyo" => 187269
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Concentration of IL-17&#44; IL-22&#44; and IL-23 in the GCF of study individuals&#46; H&#44; healthy control&#59; P&#44; individuals with untreated periodontitis&#59; S&#44; individuals with untreated psoriasis&#59; SP&#44; individuals with untreated psoriasis and untreated periodontitis&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2317
            "Ancho" => 1250
            "Tamanyo" => 106195
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Concentration of S100A7 and S100A8 in GCF of study individuals&#46; Bars and asterisk represent p&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age &#40;covariate&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age &#40;covariate&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eta-squared groups&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;83 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;054&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;26 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;295&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;047&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;19 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;279&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;36 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;784&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;54 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;218&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;68 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;565&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;026&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S100A7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;23 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;629&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;57 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;635&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S100A8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;75 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;388&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#46;62 &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;251&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2585820.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Results of effect size for analysis of variance &#40;ANOVA&#41;&#58; eta squared&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Bold&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; H&#44; healthy control&#59; P&#44; individuals with untreated periodontitis&#59; S&#44; individuals with untreated psoriasis&#59; SP&#44; individuals with untreated psoriasis and untreated periodontitis&#59; SD&#44; standard deviation&#59; PD&#44; probing depth&#59; CAL&#44; clinical attachment level&#59; BOP&#44; bleeding on probing&#59; PASI&#44; Psoriasis Area Severity Index&#59; BSA&#44; body surface area&#59; PGA&#44; Physician&#8217;s Global Assessment&#59; DLQI&#44; Dermatology Life Quality Index&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Superscript letters indicate significant differences among groups&#58; <span class="elsevierStyleSup">a</span> Present significant difference with whereas <span class="elsevierStyleSup">b</span> whereas <span class="elsevierStyleSup">c</span> present significant difference with<span class="elsevierStyleSup">d</span>&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Parameters&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">H&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">S&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#44; mean &#91;SD&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;52 &#40;10&#46;64&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;95 &#40;12&#46;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#46;16 &#40;16&#46;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;20 &#40;11&#46;43&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;0001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gender&#58; male-female &#40;n&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#8211;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#8211;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#8211;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#8211;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;342&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Smokers &#40;n&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;28&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;33&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;27&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;53&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;235&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PD &#40;mm&#44; mean &#91;SD&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;86 &#40;0&#46;24&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;24 &#40;0&#46;42&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;99 &#40;0&#46;5&#41;<span class="elsevierStyleSup">b&#44;c</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;53 &#40;0&#46;43&#41;<span class="elsevierStyleSup">d</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;0001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAL &#40;mm&#44; mean &#91;SD&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;33 &#40;0&#46;44&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;70 &#40;0&#46;64&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;56 &#40;0&#46;95&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;75 &#40;1&#46;26&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;0001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BOP &#40;&#37;&#44; mean &#91;SD&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;36 &#40;21&#46;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;80 &#40;12&#46;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;16 &#40;9&#46;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;60 &#40;14&#46;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;240&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Number of teeth &#40;n&#44; mean &#91;SD&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;24 &#40;3&#46;62&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#40;2&#46;54&#41;<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;8&#40;4&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;67 &#40;4&#46;84&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Frequency of dental brushing &#40;n per day&#44; mean &#91;SD&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;56 &#40;0&#46;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;86 &#40;0&#46;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;09&#40;0&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;24 &#40;1&#46;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PASI&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;7 &#40;7&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;35 &#40;6&#46;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;153&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BSA&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;20 &#40;13&#46;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;08 &#40;15&#46;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;531&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PGA&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;67 &#40;0&#46;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;83 &#40;6&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;79 &#40;7&#46;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;704&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2585821.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Comparison of demographic parameters&#44; smoking habits&#44; and clinical characteristics of study individuals&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:50 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;H&#46; Boehncke"
                            1 => "M&#46;P&#46; Schon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(14)61909-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2015"
                        "volumen" => "386"
                        "paginaInicial" => "983"
                        "paginaFinal" => "994"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26025581"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current knowledge on psoriasis and autoimmune diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46; Ayala-Fontanez"
                            1 => "D&#46;C&#46; Soler"
                            2 => "T&#46;S&#46; McCormick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Psoriasis &#40;Auckl&#41;"
                        "fecha" => "2016"
                        "volumen" => "6"
                        "paginaInicial" => "7"
                        "paginaFinal" => "32"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased IL17A&#44; IFNG&#44; and FOXP3 Transcripts in Moderate-Severe Psoriasis&#58; A Major Influence Exerted by IL17A in Disease Severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;S&#46; Oliveira"
                            1 => "M&#46;C&#46; Pereira"
                            2 => "S&#46;K&#46; Silva de Paula"
                            3 => "E&#46;V&#46; Lima"
                            4 => "M&#46;M&#46; Lima"
                            5 => "R&#46;G&#46; Arruda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Mediators Inflamm"
                        "fecha" => "2016"
                        "volumen" => "2016"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions&#58; enhanced expression in psoriatic skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Piskin"
                            1 => "R&#46;M&#46; Sylva-Steenland"
                            2 => "J&#46;D&#46; Bos"
                            3 => "M&#46;B&#46; Teunissen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4049/jimmunol.176.3.1908"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2006"
                        "volumen" => "176"
                        "paginaInicial" => "1908"
                        "paginaFinal" => "1915"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16424222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-17A&#44; IL-22&#44; and IL-23 as Markers of Psoriasis Activity&#58; A Cross-sectional&#44; Hospital-based Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Fotiadou"
                            1 => "E&#46; Lazaridou"
                            2 => "E&#46; Sotiriou"
                            3 => "S&#46; Gerou"
                            4 => "A&#46; Kyrgidis"
                            5 => "E&#46; Vakirlis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1203475415584503"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Med Surg"
                        "fecha" => "2015"
                        "volumen" => "19"
                        "paginaInicial" => "555"
                        "paginaFinal" => "560"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25917082"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Benoit"
                            1 => "A&#46; Toksoy"
                            2 => "M&#46; Ahlmann"
                            3 => "M&#46; Schmidt"
                            4 => "C&#46; Sunderkotter"
                            5 => "D&#46; Foell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2006"
                        "volumen" => "155"
                        "paginaInicial" => "62"
                        "paginaFinal" => "66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S100A7&#44; Jab1&#44; and p27&#40;kip1&#41; expression in psoriasis and S100A7 CRISPR-activated human keratinocyte cell line"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Granata"
                            1 => "E&#46; Skarmoutsou"
                            2 => "P&#46; Gangemi"
                            3 => "M&#46;C&#46; Mazzarino"
                            4 => "F&#46; D&#8217;Amico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcb.27609"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cell Biochem"
                        "fecha" => "2019"
                        "volumen" => "120"
                        "paginaInicial" => "3384"
                        "paginaFinal" => "3392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30203426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overexpression of Psoriasin &#40;S100A7&#41; Contributes to Dysregulated Differentiation in Psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;K&#46; Ekman"
                            1 => "J&#46; Vegfors"
                            2 => "C&#46;B&#46; Eding"
                            3 => "C&#46; Enerback"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-2596"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "2017"
                        "volumen" => "97"
                        "paginaInicial" => "441"
                        "paginaFinal" => "448"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27958610"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Lee"
                            1 => "S&#46; Jang"
                            2 => "J&#46;K&#46; Min"
                            3 => "K&#46; Lee"
                            4 => "K&#46;C&#46; Sohn"
                            5 => "J&#46;S&#46; Lim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Biophys Res Commun&#46;"
                        "fecha" => "2012"
                        "volumen" => "423"
                        "paginaInicial" => "647"
                        "paginaFinal" => "653"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673603128887"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of periodontitis in patients with psoriasis and psoriatic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Egeberg"
                            1 => "L&#46; Mallbris"
                            2 => "G&#46; Gislason"
                            3 => "P&#46;R&#46; Hansen"
                            4 => "U&#46; Mrowietz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13814"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2017"
                        "volumen" => "31"
                        "paginaInicial" => "288"
                        "paginaFinal" => "293"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27439545"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0190962210008674"
                          "estado" => "S300"
                          "issn" => "01909622"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between moderate to severe psoriasis and periodontitis in a Scandinavian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Skudutyte-Rysstad"
                            1 => "E&#46;M&#46; Slevolden"
                            2 => "B&#46;F&#46; Hansen"
                            3 => "L&#46; Sandvik"
                            4 => "H&#46;R&#46; Preus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1472-6831-14-139"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Oral Health&#46;"
                        "fecha" => "2014"
                        "volumen" => "14"
                        "paginaInicial" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25427764"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of chronic plaque psoriasis and severe periodontitis&#58; a hospital based case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Lazaridou"
                            1 => "A&#46; Tsikrikoni"
                            2 => "C&#46; Fotiadou"
                            3 => "E&#46; Kyrmanidou"
                            4 => "E&#46; Vakirlis"
                            5 => "C&#46; Giannopoulou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2012.04615.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2013"
                        "volumen" => "27"
                        "paginaInicial" => "967"
                        "paginaFinal" => "972"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22703187"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Periodontal disease&#58; an oral manifestation of psoriasis or an occasional finding&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Ganzetti"
                            1 => "A&#46; Campanati"
                            2 => "A&#46; Santarelli"
                            3 => "V&#46; Pozzi"
                            4 => "E&#46; Molinelli"
                            5 => "I&#46; Minnetti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ddr.21194"
                      "Revista" => array:7 [
                        "tituloSerie" => "Drug Dev Res&#46;"
                        "fecha" => "2014"
                        "volumen" => "75"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "S46"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25381976"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk of periodontitis in patients with psoriatic disease&#58; a nationwide population-based retrospective cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;Y&#46; Su"
                            1 => "J&#46;Y&#46; Huang"
                            2 => "C&#46;J&#46; Hu"
                            3 => "Chang Y&#46;C&#46; Yu HC"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7717/peerj.4064"
                      "Revista" => array:5 [
                        "tituloSerie" => "PeerJ&#46;"
                        "fecha" => "2017"
                        "volumen" => "5"
                        "paginaInicial" => "e4064"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29158990"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Periodontal disease and risk of psoriasis among nurses in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Nakib"
                            1 => "J&#46; Han"
                            2 => "T&#46; Li"
                            3 => "K&#46; Joshipura"
                            4 => "A&#46;A&#46; Qureshi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Odontol Scand&#46;"
                        "fecha" => "2013"
                        "volumen" => "71"
                        "paginaInicial" => "1423"
                        "paginaFinal" => "1429"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression levels of th-2 and th-17 characteristic genes in healthy tissue versus periodontitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Behfarnia"
                            1 => "R&#46; Birang"
                            2 => "S&#46;S&#46; Pishva"
                            3 => "M&#46;G&#46; Hakemi"
                            4 => "M&#46;M&#46; Khorasani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dent &#40;Tehran&#41;"
                        "fecha" => "2013"
                        "volumen" => "10"
                        "paginaInicial" => "23"
                        "paginaFinal" => "31"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased levels of the T-helper 22-associated cytokine &#40;interleukin-22&#41; and transcription factor &#40;aryl hydrocarbon receptor&#41; in patients with periodontitis are associated with osteoclast resorptive activity and severity of the disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Diaz-Zuniga"
                            1 => "S&#46; Melgar-Rodriguez"
                            2 => "L&#46; Rojas"
                            3 => "C&#46; Alvarez"
                            4 => "G&#46; Monasterio"
                            5 => "P&#46; Carvajal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Periodontal Res"
                        "fecha" => "2017"
                        "volumen" => "52"
                        "paginaInicial" => "893"
                        "paginaFinal" => "902"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical significance of GCF sIL-6R and calprotectin to evaluate the periodontal inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Kajiura"
                            1 => "J&#46;H&#46; Lew"
                            2 => "T&#46; Ikuta"
                            3 => "Y&#46; Nishikawa"
                            4 => "J&#46;I&#46; Kido"
                            5 => "T&#46; Nagata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0004563216680232"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Clin Biochem"
                        "fecha" => "2017"
                        "volumen" => "54"
                        "paginaInicial" => "664"
                        "paginaFinal" => "670"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27810997"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calprotectin&#44; a leukocyte protein related to inflammation&#44; in gingival crevicular fluid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Kido"
                            1 => "T&#46; Nakamura"
                            2 => "R&#46; Kido"
                            3 => "K&#46; Ohishi"
                            4 => "N&#46; Yamauchi"
                            5 => "M&#46; Kataoka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0765.1998.tb02340.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Periodontal Res&#46;"
                        "fecha" => "1998"
                        "volumen" => "33"
                        "paginaInicial" => "434"
                        "paginaFinal" => "437"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9842509"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative Analysis of Calcium-Binding Myeloid-Related Protein-8&#47;14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Haririan"
                            1 => "O&#46; Andrukhov"
                            2 => "E&#46; Pablik"
                            3 => "M&#46; Neuhofer"
                            4 => "A&#46; Moritz"
                            5 => "X&#46; Rausch-Fan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1902/jop.2015.150254"
                      "Revista" => array:6 [
                        "tituloSerie" => "&#46; J Periodontol"
                        "fecha" => "2016"
                        "volumen" => "87"
                        "paginaInicial" => "184"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26447749"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Salivary S100 proteins screen periodontitis among Korean adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Karna"
                            1 => "Y&#46;J&#46; Shin"
                            2 => "S&#46; Kim"
                            3 => "H&#46;D&#46; Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jcpe.13059"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Periodontol&#46;"
                        "fecha" => "2019"
                        "volumen" => "46"
                        "paginaInicial" => "181"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30592072"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46;B&#46; Lamster"
                            1 => "J&#46;K&#46; Ahlo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1196/annals.1384.027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann N Y Acad Sci"
                        "fecha" => "2007"
                        "volumen" => "1098"
                        "paginaInicial" => "216"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17435131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case definitions for use in population-based surveillance of periodontitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;C&#46; Page"
                            1 => "P&#46;I&#46; Eke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1902/jop.2007.060264"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Periodontol&#46;"
                        "fecha" => "2007"
                        "volumen" => "78"
                        "numero" => "7 Suppl"
                        "paginaInicial" => "1387"
                        "paginaFinal" => "1399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17608611"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Explaining phenotype heterogeneity in patients with psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Christophers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2007.08307.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2008"
                        "volumen" => "158"
                        "paginaInicial" => "437"
                        "paginaFinal" => "441"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18047519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Host response mechanisms in periodontal diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Silva"
                            1 => "L&#46; Abusleme"
                            2 => "D&#46; Bravo"
                            3 => "N&#46; Dutzan"
                            4 => "J&#46; Garcia-Sesnich"
                            5 => "R&#46; Vernal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/1678-775720140259"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Oral Sci&#46;"
                        "fecha" => "2015"
                        "volumen" => "23"
                        "paginaInicial" => "329"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26221929"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochemical localization of CD1a and S100 in gingival tissues of healthy and chronic periodontitis subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Anjana"
                            1 => "L&#46; Joseph"
                            2 => "R&#46; Suresh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Dis&#46;"
                        "fecha" => "2012"
                        "volumen" => "18"
                        "paginaInicial" => "778"
                        "paginaFinal" => "785"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-22&#47;IL-22R1 axis and S100A8&#47;A9 alarmins in human osteoarthritic and rheumatoid arthritis synovial fibroblasts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Carrion"
                            1 => "Y&#46; Juarranz"
                            2 => "C&#46; Martinez"
                            3 => "I&#46; Gonzalez-Alvaro"
                            4 => "J&#46;L&#46; Pablos"
                            5 => "I&#46; Gutierrez-Canas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/ket315"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;&#46;"
                        "fecha" => "2013"
                        "volumen" => "52"
                        "paginaInicial" => "2177"
                        "paginaFinal" => "2186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24056519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Among the S100 proteins&#44; S100A12 is the most significant marker for psoriasis disease activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Wilsmann-Theis"
                            1 => "J&#46; Wagenpfeil"
                            2 => "D&#46; Holzinger"
                            3 => "J&#46; Roth"
                            4 => "S&#46; Koch"
                            5 => "S&#46; Schnautz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13269"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2016"
                        "volumen" => "30"
                        "paginaInicial" => "1165"
                        "paginaFinal" => "1170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26333514"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of proteins in human gingival crevicular fluid by mass spectrometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Kido"
                            1 => "M&#46; Bando"
                            2 => "Y&#46; Hiroshima"
                            3 => "H&#46; Iwasaka"
                            4 => "K&#46; Yamada"
                            5 => "N&#46; Ohgami"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Periodontal Res&#46;"
                        "fecha" => "2012"
                        "volumen" => "47"
                        "paginaInicial" => "488"
                        "paginaFinal" => "499"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4&#58; implications for bone destruction in murine antigen-induced arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;C&#46; Grevers"
                            1 => "T&#46;J&#46; de Vries"
                            2 => "T&#46; Vogl"
                            3 => "S&#46; Abdollahi-Roodsaz"
                            4 => "A&#46;W&#46; Sloetjes"
                            5 => "P&#46;J&#46; Leenen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.30290"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum&#46;"
                        "fecha" => "2011"
                        "volumen" => "63"
                        "paginaInicial" => "1365"
                        "paginaFinal" => "1375"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21337316"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanical stress induced S100A7 expression in human dental pulp cells to augment osteoclast differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Charoenpong"
                            1 => "T&#46; Osathanon"
                            2 => "P&#46; Pavasant"
                            3 => "N&#46; Limjeerajarus"
                            4 => "B&#46; Keawprachum"
                            5 => "C&#46;N&#46; Limjeerajarus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/odi.13033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Dis&#46;"
                        "fecha" => "2019"
                        "volumen" => "25"
                        "paginaInicial" => "812"
                        "paginaFinal" => "821"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30614184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral fluid-based biomarkers in periodontal disease - part 2&#46; Gingival crevicular fluid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; AlRowis"
                            1 => "H&#46;S&#46; AlMoharib"
                            2 => "A&#46; AlMubarak"
                            3 => "J&#46; Bhaskardoss"
                            4 => "R&#46;S&#46; Preethanath"
                            5 => "S&#46; Anil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Int Oral Health"
                        "fecha" => "2014"
                        "volumen" => "6"
                        "paginaInicial" => "126"
                        "paginaFinal" => "135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25395809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis&#58; crucial &#8220;human osteoclastology&#8221;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Kotake"
                            1 => "T&#46; Yago"
                            2 => "M&#46; Kawamoto"
                            3 => "Y&#46; Nanke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00774-011-0321-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Bone Miner Metab"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "125"
                        "paginaFinal" => "135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21960179"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0738081X1200034X"
                          "estado" => "S300"
                          "issn" => "0738081X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-17 regulates the expressions of RANKL and OPG in human periodontal ligament cells via TRAF6&#47;TBK1-JNK&#47;NF-kappaB pathways"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Lin"
                            1 => "L&#46; Li"
                            2 => "Y&#46; Sun"
                            3 => "W&#46; Wang"
                            4 => "X&#46; Wang"
                            5 => "Y&#46; Ye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Immunology"
                        "fecha" => "2015"
                        "volumen" => "144"
                        "paginaInicial" => "472"
                        "paginaFinal" => "485"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of interleukin23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Ma"
                            1 => "D&#46; Yang"
                            2 => "H&#46; Okamura"
                            3 => "J&#46; Teramachi"
                            4 => "T&#46; Hasegawa"
                            5 => "L&#46; Qiu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3892/mmr.2016.6041"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Med Rep&#46;"
                        "fecha" => "2017"
                        "volumen" => "15"
                        "paginaInicial" => "559"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28000855"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; Awang"
                            1 => "D&#46;F&#46; Lappin"
                            2 => "A&#46; MacPherson"
                            3 => "M&#46; Riggio"
                            4 => "D&#46; Robertson"
                            5 => "P&#46; Hodge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00011-014-0776-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Res"
                        "fecha" => "2014"
                        "volumen" => "63"
                        "paginaInicial" => "1001"
                        "paginaFinal" => "1012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25369802"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Sadeghi"
                            1 => "M&#46; Sattari"
                            2 => "F&#46; Dehghan"
                            3 => "S&#46; Akbari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5114/ceji.2018.74876"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cent Eur J Immunol&#46;"
                        "fecha" => "2018"
                        "volumen" => "43"
                        "paginaInicial" => "76"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29736149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association study between salivary levels of interferon &#40;IFN&#41;-gamma&#44; interleukin &#40;IL&#41;-17&#44; IL-21&#44; and IL-22 with chronic periodontitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;M&#46; Isaza-Guzman"
                            1 => "N&#46; Cardona-Velez"
                            2 => "D&#46;E&#46; Gaviria-Correa"
                            3 => "M&#46;C&#46; Martinez-Pabon"
                            4 => "M&#46;C&#46; Castano-Granada"
                            5 => "S&#46;I&#46; Tobon-Arroyave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.archoralbio.2014.09.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Oral Biol"
                        "fecha" => "2015"
                        "volumen" => "60"
                        "paginaInicial" => "91"
                        "paginaFinal" => "99"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25285903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gingival crevicular fluid and interleukin-23 concentration in systemically healthy subjects&#58; their relationship in periodontal health and disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;S&#46; Himani"
                            1 => "M&#46;L&#46; Prabhuji"
                            2 => "B&#46;V&#46; Karthikeyan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jre.12100"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Periodontal Res&#46;"
                        "fecha" => "2014"
                        "volumen" => "49"
                        "paginaInicial" => "237"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23721589"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum levels of TNF-alpha&#44; IFN-gamma&#44; IL-6&#44; IL-8&#44; IL-12&#44; IL-17&#44; and IL-18 in patients with active psoriasis and correlation with disease severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Arican"
                            1 => "M&#46; Aral"
                            2 => "S&#46; Sasmaz"
                            3 => "P&#46; Ciragil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/MI.2005.273"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mediators Inflamm&#46;"
                        "fecha" => "2005"
                        "volumen" => "2005"
                        "paginaInicial" => "273"
                        "paginaFinal" => "279"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16258194"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Soderstrom"
                            1 => "G&#46; Berstein"
                            2 => "W&#46; Zhang"
                            3 => "H&#46; Valdez"
                            4 => "L&#46; Fitz"
                            5 => "M&#46; Kuhn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1208/s12248-017-0094-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "AAPS J"
                        "fecha" => "2017"
                        "volumen" => "19"
                        "paginaInicial" => "1218"
                        "paginaFinal" => "1222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28534291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Palmoplantar pustular psoriasis &#40;PPPP&#41; is characterized by activation of the IL-17A pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Bissonnette"
                            1 => "J&#46; Fuentes-Duculan"
                            2 => "S&#46; Mashiko"
                            3 => "X&#46; Li"
                            4 => "K&#46;M&#46; Bonifacio"
                            5 => "I&#46; Cueto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdermsci.2016.09.019"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Sci&#46;"
                        "fecha" => "2017"
                        "volumen" => "85"
                        "paginaInicial" => "20"
                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27743912"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gingival crevicular fluid&#44; serum levels of receptor activator of nuclear factor-kappaB ligand&#44; osteoprotegerin&#44; and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Gumus"
                            1 => "E&#46; Buduneli"
                            2 => "B&#46; Biyikoglu"
                            3 => "K&#46; Aksu"
                            4 => "F&#46; Sarac"
                            5 => "C&#46; Nile"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1902/jop.2013.120595"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Periodontol&#46;"
                        "fecha" => "2013"
                        "volumen" => "84"
                        "paginaInicial" => "1627"
                        "paginaFinal" => "1637"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23327689"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;G&#46; de Aquino"
                            1 => "S&#46; Abdollahi-Roodsaz"
                            2 => "M&#46;I&#46; Koenders"
                            3 => "F&#46;A&#46; van de Loo"
                            4 => "G&#46;J&#46; Pruijn"
                            5 => "R&#46;J&#46; Marijnissen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2014"
                        "volumen" => "192"
                        "paginaInicial" => "4103"
                        "paginaFinal" => "4111"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Periodontitis increases rheumatic factor serum levels and citrullinated proteins in gingival tissues and alter cytokine balance in arthritic rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;G&#46; Correa"
                            1 => "S&#46;B&#46; Sacchetti"
                            2 => "F&#46;V&#46; Ribeiro"
                            3 => "S&#46;P&#46; Pimentel"
                            4 => "R&#46;C&#46; Casarin"
                            5 => "F&#46;R&#46; Cirano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0189910"
                      "Revista" => array:4 [
                        "tituloSerie" => "PLoS One"
                        "fecha" => "2017"
                        "volumen" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29287100"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis-like skin lesions are dependent on IL-23 but develop in the absence of IL-22 in a model mouse"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Takaishi"
                            1 => "K&#46; Nakajima"
                            2 => "W&#46; Ouyang"
                            3 => "S&#46; Sano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdermsci.2013.11.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Sci"
                        "fecha" => "2014"
                        "volumen" => "73"
                        "paginaInicial" => "261"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24315761"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Van Belle"
                            1 => "M&#46; de Heusch"
                            2 => "M&#46;M&#46; Lemaire"
                            3 => "E&#46; Hendrickx"
                            4 => "G&#46; Warnier"
                            5 => "K&#46; Dunussi-Joannopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol&#46;"
                        "fecha" => "2012"
                        "volumen" => "188"
                        "paginaInicial" => "462"
                        "paginaFinal" => "469"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation of IL-12&#44; IL-22&#44; and IL-23 in patients with psoriasis and metabolic syndrome&#46; Preliminary report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Brito-Luna"
                            1 => "D&#46;G&#46; Villanueva-Quintero"
                            2 => "A&#46;K&#46; Sandoval-Talamantes"
                            3 => "M&#46; Fafutis-Morris"
                            4 => "O&#46; Graciano-Machuca"
                            5 => "P&#46;E&#46; Sanchez-Hernandez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cyto.2016.06.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cytokine"
                        "fecha" => "2016"
                        "volumen" => "85"
                        "paginaInicial" => "130"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27344023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin-infiltrating&#44; interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;M&#46; Cordoro"
                            1 => "M&#46; Hitraya-Low"
                            2 => "K&#46; Taravati"
                            3 => "P&#46;M&#46; Sandoval"
                            4 => "E&#46; Kim"
                            5 => "J&#46; Sugarman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2017.05.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "77"
                        "paginaInicial" => "417"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28624119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of the Expression Profile of JunB&#44; c-Jun&#44; and S100A8 &#40;Calgranulin A&#41; in Psoriasis Vulgaris and Guttate Psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;C&#46; Park"
                            1 => "K&#46;J&#46; Kim"
                            2 => "S&#46;Y&#46; Woo"
                            3 => "J&#46;H&#46; Chun"
                            4 => "K&#46;H&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5021/ad.2009.21.1.35"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol&#46;"
                        "fecha" => "2009"
                        "volumen" => "21"
                        "paginaInicial" => "35"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20548852"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000015/v2_202104300920/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "89516"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000002/v2_202104300920/S0365059621000015/v2_202104300920/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000015?idApp=UINPBA00008Z"
]

Informação do artigo

ISSN: 03650596
Idioma original: Inglês

DOI:10.1016/j.abd.2020.08.008

Dados atualizados diariamente

Ano/Mês	Html	Pdf	Total

2024 Novembro	20	6	26
2024 Outubro	121	85	206
2024 Setembro	143	84	227
2024 Agosto	144	122	266
2024 Julho	156	120	276
2024 Junho	136	85	221
2024 Maio	91	69	160
2024 Abril	116	78	194
2024 Mar�o	102	90	192
2024 Fevereiro	144	82	226
2024 Janeiro	84	63	147
2023 Dezembro	109	61	170
2023 Novembro	120	88	208
2023 Outubro	83	82	165
2023 Setembro	71	71	142
2023 Agosto	67	44	111
2023 Julho	62	33	95
2023 Junho	63	47	110
2023 Maio	67	24	91
2023 Abril	53	23	76
2023 Mar�o	100	56	156
2023 Fevereiro	61	36	97
2023 Janeiro	47	58	105
2022 Dezembro	66	34	100
2022 Novembro	72	61	133
2022 Outubro	149	77	226
2022 Setembro	53	61	114
2022 Agosto	41	60	101
2022 Julho	50	62	112
2022 Junho	54	60	114
2022 Maio	57	57	114
2022 Abril	157	56	213
2022 Mar�o	66	72	138
2022 Fevereiro	34	33	67
2022 Janeiro	62	84	146
2021 Dezembro	51	65	116
2021 Novembro	55	60	115
2021 Outubro	54	116	170
2021 Setembro	39	75	114
2021 Agosto	43	58	101
2021 Julho	78	56	134
2021 Junho	130	73	203
2021 Maio	133	110	243
2021 Abril	348	338	686
2021 Mar�o	88	59	147
2021 Fevereiro	20	13	33
2021 Janeiro	3	2	5

Mostrar tudo

Indexada em:

Siga-nos:

Inscreva-se:

Estatísticas

Indexada em:

Siga-nos:

Inscreva-se:

Estatísticas

Receba a nossa Newsletter