Case Letter
Etanercept-induced palisaded neutrophilic granulomatous dermatitis
Masato Ishikawa
, Toshiyuki Yamamoto
Autor para correspondência
Fukushima Medical University, Fukushima, Japan
Lido
5679
Vezesque se leu este artigo
2782
Total PDF
2897
Total HTML
Compartilhar estatÃsticas
array:23 [ "pii" => "S0365059620303032" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.06.005" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "289" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2020" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275220303544" "issn" => "26662752" "doi" => "10.1016/j.abdp.2020.06.006" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "289" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta ‐ Caso clínico</span>" "titulo" => "Dermatite granulomatosa neutrofílica em paliçada induzida por etanercepte" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "117" "paginaFinal" => "119" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 530 "Ancho" => 750 "Tamanyo" => 49106 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Características clínicas do tronco. Esndurecimento cutâneo de cor avermelhada com sensibilidade aumentada e edema na região mamária esquerda.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Masato Ishikawa, Toshiyuki Yamamoto" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Masato" "apellidos" => "Ishikawa" ] 1 => array:2 [ "nombre" => "Toshiyuki" "apellidos" => "Yamamoto" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059620303032" "doi" => "10.1016/j.abd.2020.06.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303032?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303544?idApp=UINPBA00008Z" "url" => "/26662752/0000009600000001/v2_202102130748/S2666275220303544/v2_202102130748/pt/main.assets" ] ] "itemAnterior" => array:19 [ "pii" => "S0365059620303123" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.06.007" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "298" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Epithelioid sarcoma of the upper limb with nine years of evolution" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "116" "paginaFinal" => "117" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 754 "Ancho" => 750 "Tamanyo" => 205530 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathological examination showing an infiltrative neoplasm consisting of epithelioid and spindle cells with eosinophilic cytoplasm and irregular nuclei with evident nucleoli (Hematoxylin & eosin, ×400).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maraya de Jesus Semblano Bittencourt, Caren dos Santos Lima, Aline de Lima Dias, Camilla Côrrea Neri" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Maraya de Jesus Semblano" "apellidos" => "Bittencourt" ] 1 => array:2 [ "nombre" => "Caren dos Santos" "apellidos" => "Lima" ] 2 => array:2 [ "nombre" => "Aline de Lima" "apellidos" => "Dias" ] 3 => array:2 [ "nombre" => "Camilla Côrrea" "apellidos" => "Neri" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220303647" "doi" => "10.1016/j.abdp.2020.06.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303647?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303123?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620303123/v3_202102051036/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Etanercept-induced palisaded neutrophilic granulomatous dermatitis" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor,</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "117" "paginaFinal" => "119" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Masato Ishikawa, Toshiyuki Yamamoto" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Masato" "apellidos" => "Ishikawa" "email" => array:1 [ 0 => "ishimasa@fmu.ac.jp" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Toshiyuki" "apellidos" => "Yamamoto" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Fukushima Medical University, Fukushima, Japan" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 530 "Ancho" => 750 "Tamanyo" => 48857 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical features of the trunk. A reddish induration with tenderness and swelling on the left breast.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 37-year-old female was referred to this hospital, complaining of fever and induration and swelling of the chest wall. She had rheumatoid arthritis and been treated with non-steroidal anti-inflammatory drugs and methotrexate for six years, as well as etanercept (25 mg per three weeks) for two years, prior to presentation. Physical examination revealed a reddish induration with tenderness and swelling of the left breast (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). It was also accompanied by a number of tiny pustules. Laboratory data showed positive anti-nuclear antibody (1:160), elevated C-reactive protein (14.91 mg/dL), anti-SS-A antibodies (> 240 U/mL), and positive Schirmer’s test (left eye; 2 mm). The patient had not been diagnosed as having Sjögren’s syndrome until presentation at this hospital. A biopsy specimen showed basophilic degeneration of collagen fibers mixed with numerous nuclear debris in the upper dermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). There was also mild interface dermatitis. Immunohistochemistry results revealed a number of CD68-positive palisaded histiocytes surrounding degenerated collagen fibers (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Although the patient was treated with antibiotics for cellulitis initially, these had little effect. Since the patient did not show any other obvious symptoms, several studies were performed in order to identify the source of fever. Examination of cerebrospinal fluid revealed that she had aseptic meningitis, which was considered as a part of the central nervous system involvement in autoimmune disease. The patient’s fever and induration improved with 50 mg of prednisolone. After recovery, etanercept therapy was stopped. Although the patient continued treatment with non-steroidal anti-inflammatory drugs and methotrexate, three months after stopping etanercept, she was free from recurrence.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">In the present case, infiltrative erythema occurred in a patient with rheumatoid arthritis and Sjögren’s syndrome two years after starting treatment with etanercept, and the eruption has not occurred since the etanercept treatment was stopped. Histopathological examination revealed characteristic findings of palisaded neutrophilic granulomatous dermatitis (PNGD) and interface dermatitis. Considering the clinical course and the histopathological features, PNGD could be induced by etanercept in the present case. PNGD is a pathological concept characterized by an inflammation pattern showing a palisading infiltration of histiocyte surrounding areas of necrobiosis, which occasionally occurs in patients with autoimmune diseases such as rheumatoid arthritis, Sjögren’s syndrome, and eosinophilic granulomatosis with polyangiitis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> To date, there have only been few reported cases of PNGD occurring after treatment with etanercept, including the present case.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> In contrast to other TNF-α inhibitors, etanercept, a receptor fusion protein, is considered not to strongly suppress TNF-α activity and this may enable TNF-α to form granuloma. Otherwise, etanercept may modulate cytokines other than TNF, which cannot be done by other TNF inhibitors. In addition, etanercept can enhance T-cell production of interferon-gamma, which is a key player in granuloma formation.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> By contrast, there are reports that adalimumab and infliximab also induce sarcoid or sarcoid-like granulomas, and thus other mechanisms leading to granuloma induction may exist. Further studies are necessary to clarify the mechanisms of TNF inhibitors-induced granulomatous diseases.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0015" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors' contributions</span><p id="par0020" class="elsevierStylePara elsevierViewall">Masato Ishikawa: Design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; critical review of the literature.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Toshiyuki Yamamoto: Approval of the final version of the manuscript; design and planning of the study.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors' contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-02-18" "fechaAceptado" => "2020-06-16" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Ishikawa M, Yamamoto T. Etanercept-induced palisaded neutrophilic granulomatous dermatitis. An Bras Dermatol. 2021;96:117–9.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Department of Dermatology, Fukushima Medical University, Fukushima, Japan.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 530 "Ancho" => 750 "Tamanyo" => 48857 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical features of the trunk. A reddish induration with tenderness and swelling on the left breast.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 569 "Ancho" => 750 "Tamanyo" => 158853 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The histopathological specimen showed basophilic degeneration of collagen fiber, mixed with numerous nuclear debris in the upper dermis (Hematoxylin & eosin, ×100).</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 569 "Ancho" => 750 "Tamanyo" => 145331 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Palisaded histiocytes surrounding degenerated collagen fibers (CD68, ×100).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Palisaded neutrophilic and granulomatous dermatitis associated with limited systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.M. Hantash" 1 => "D. Chiang" 2 => "S. Kohler" 3 => "D. Fiorentino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.09.019" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2008" "volumen" => "58" "paginaInicial" => "661" "paginaFinal" => "664" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17945384" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Palisaded neutrophilic granulomatous dermatitis in a child with juvenile idiopathic arthritis on etanercept" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.A. Nguyen" 1 => "N.J. Celano" 2 => "C. Matiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/pde.12797" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol." "fecha" => "2016" "volumen" => "33" "paginaInicial" => "e156" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26860064" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Palisaded neutrophilic and granulomatous dermatitis associated with the initiation of etanercept in rheumatoid arthritis: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.L. Chou" 1 => "K.H. Wang" 2 => "Y.Y. Chiang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Sin." "fecha" => "2011" "volumen" => "29" "paginaInicial" => "129" "paginaFinal" => "133" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Deng" 1 => "V. Harvey" 2 => "B. Sina" 3 => "D. Strobel" 4 => "A. Badros" 5 => "J.M. Junkins-Hopkins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Dermatol." "fecha" => "2006" "volumen" => "142" "paginaInicial" => "198" "paginaFinal" => "202" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.I. Daïen" 1 => "A. Monnier" 2 => "P. Claudepierre" 3 => "A. Constantin" 4 => "J.P. Eschard" 5 => "E. Houvenagel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/kep046" "Revista" => array:6 [ "tituloSerie" => "Rheumatology (Oxford)." "fecha" => "2009" "volumen" => "48" "paginaInicial" => "883" "paginaFinal" => "886" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19423648" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620303032/v3_202102051036/en/main.assets" "Apartado" => array:4 [ "identificador" => "82769" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Letter" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000001/v3_202102051036/S0365059620303032/v3_202102051036/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303032?idApp=UINPBA00008Z" ]
| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 12 | 7 | 19 |
| 2024 Outubro | 102 | 74 | 176 |
| 2024 Setembro | 143 | 72 | 215 |
| 2024 Agosto | 145 | 113 | 258 |
| 2024 Julho | 111 | 116 | 227 |
| 2024 Junho | 94 | 68 | 162 |
| 2024 Maio | 75 | 69 | 144 |
| 2024 Abril | 87 | 86 | 173 |
| 2024 Março | 86 | 54 | 140 |
| 2024 Fevereiro | 80 | 72 | 152 |
| 2024 Janeiro | 69 | 42 | 111 |
| 2023 Dezembro | 49 | 72 | 121 |
| 2023 Novembro | 60 | 64 | 124 |
| 2023 Outubro | 57 | 59 | 116 |
| 2023 Setembro | 68 | 69 | 137 |
| 2023 Agosto | 62 | 38 | 100 |
| 2023 Julho | 62 | 25 | 87 |
| 2023 Junho | 42 | 31 | 73 |
| 2023 Maio | 49 | 20 | 69 |
| 2023 Abril | 34 | 21 | 55 |
| 2023 Março | 59 | 37 | 96 |
| 2023 Fevereiro | 53 | 33 | 86 |
| 2023 Janeiro | 46 | 34 | 80 |
| 2022 Dezembro | 52 | 32 | 84 |
| 2022 Novembro | 53 | 44 | 97 |
| 2022 Outubro | 71 | 48 | 119 |
| 2022 Setembro | 38 | 58 | 96 |
| 2022 Agosto | 32 | 32 | 64 |
| 2022 Julho | 34 | 51 | 85 |
| 2022 Junho | 39 | 57 | 96 |
| 2022 Maio | 38 | 53 | 91 |
| 2022 Abril | 40 | 45 | 85 |
| 2022 Março | 48 | 68 | 116 |
| 2022 Fevereiro | 27 | 49 | 76 |
| 2022 Janeiro | 48 | 70 | 118 |
| 2021 Dezembro | 35 | 54 | 89 |
| 2021 Novembro | 51 | 62 | 113 |
| 2021 Outubro | 54 | 99 | 153 |
| 2021 Setembro | 44 | 51 | 95 |
| 2021 Agosto | 50 | 62 | 112 |
| 2021 Julho | 36 | 43 | 79 |
| 2021 Junho | 39 | 43 | 82 |
| 2021 Maio | 83 | 85 | 168 |
| 2021 Abril | 128 | 258 | 386 |
| 2021 Março | 122 | 83 | 205 |
| 2021 Fevereiro | 55 | 27 | 82 |
| 2021 Janeiro | 28 | 23 | 51 |
| 2020 Dezembro | 7 | 9 | 16 |
Mostrar tudo
