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such as a pearly appearance and the presence of telangiectasias&#44; together with slow growth&#44; especially in places exposed to the sun in fair-skinned individuals&#46; Dermoscopy allows the identification of structures described for BCC&#44; such as arborizing telangiectasia&#44; thin and short telangiectasias&#44; spoke-wheel-like structures and leaf-like structures&#44; in addition to blue-gray globules and ovoid nests&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> Histopathological examination is essential to confirm diagnosis and estimate the risk of recurrence&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The nomenclature of the morphological presentations of the BCC varies according to each author&#59; the following subtypes can be distinguished based on their different clinical and histological appearance&#58; nodular BCC&#44; superficial BCC&#44; and sclerodermiform BCC&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> The nodular subtype is responsible for 50&#37; to 80&#37; of all cases of BCC&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> The micronodular&#44; infiltrative&#44; sclerodermiform&#44; and basosquamous histological subtypes are associated with more aggressive behavior&#44; such as higher rates of recurrence and greater invasion of the dermis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Treatment options for BCC include conventional surgical excision&#44; Mohs micrographic surgery&#44; curettage with or without electrodissection&#44; cryosurgery&#44; photodynamic therapy&#44; radiotherapy&#44; and drug therapy with topical&#44; oral&#44; or intralesional injections&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;22</span></a> Treatment options are dictated by the size of the tumor&#44; location&#44; histological subtype&#44; treatment adherence&#44; medical comorbidities&#44; and cosmetic result&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Conventional surgical excision is the treatment of choice for most BCCs&#44; being the most commonly adopted&#46; Although there are several treatments for low-risk BCC&#44; such as topical therapy with imiquimod&#44; surgery is considered the gold standard&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;23</span></a> In order to decrease the number of incomplete excisions&#44; a peritumoral margin of at least 4&#8239;mm of clinically normal skin is the standard for conventional surgical excision of BCCs&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a> For noble anatomical structures&#44; such as areas of the face&#44; this margin can be considered large&#59; it can be reduced to less than 4&#8239;mm and assessed during the intraoperative period using the Mohs technique&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> High-risk BCC is associated with a higher incidence of local recurrence&#44; subclinical tumor extension&#44; incomplete excision&#44; and aggressive behavior&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">For patients who had incomplete BCC excisions&#44; some authors opt for re-excision&#44; while others opt for clinical follow-up&#46; Approaching a tumor with compromised margins is challenging&#46; Thus&#44; studies that evaluate the evolution of the management and the prognosis are extremely important&#44; since they can reduce morbidity&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The present study aimed to analyze the cases of BCCs that were operated on in a tertiary hospital between 2008 and 2013 and whose margins were compromised&#44; seeking to evaluate the type of conduct adopted &#40;whether clinical follow-up or re-excision&#41; in order to compare the results obtained&#44; as well as all the factors that could possibly be associated with these results&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Sample characterization and data collection</span><p id="par0045" class="elsevierStylePara elsevierViewall">The medical records of patients who had incomplete excised BCCs from 2008 to 2013 using the PathoControl<span class="elsevierStyleItalic">&#174;</span> software were separated for analysis&#46; The keywords for search&#44; in addition to &#8220;basal cell&#8221;&#44; were&#58; &#8220;small&#8221;&#44; &#8220;slender&#8221;&#44; &#8220;narrow&#8221;&#44; &#8220;leaning&#8221;&#44; and &#8220;compromised&#8221;&#44; both in singular and plural&#44; as well as in uppercase and lowercase letters&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The medical records of patients who died&#44; were under the age of 18&#44; were operated on by specialists other than dermatologists&#44; or those that presented incomplete data were excluded&#46; The medical records of patients who underwent only biopsy&#44; partial excision&#44; minimum follow-up of less than three months&#44; or who obtained tumor-free margins were also excluded&#59; thus&#44; a total of 120 medical records were analyzed&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The variables studied included&#58; age&#44; sex&#44; location&#44; histological subtype&#44; tumor size&#44; type of compromised margin &#40;lateral&#44; deep&#44; and both&#41;&#44; type of follow-up &#40;clinical or surgical&#41;&#44; type of surgical approach &#40;conventional or Mohs&#41;&#44; presence or absence of residual tumor in the re-excision&#44; recurrence&#44; and time of follow-up&#46;</p><p id="par1060" class="elsevierStylePara elsevierViewall">This study was approved by the Research Ethics Committee&#46; Opinion number&#58; 3&#44;515&#44;060&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Analysis of medical records</span><p id="par0060" class="elsevierStylePara elsevierViewall">The variables were analyzed descriptively&#44; comparing absolute and percentage frequencies and&#44; statistically&#44; comparing the relationship between these variables and tumor recurrence&#46; A third analysis took into account the patients&#39; follow-up time&#44; allowing the establishment of disease-free time relationships&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The descriptive analysis was performed with frequency tables for categorical variables&#44; and measures of position and dispersion for numerical variables&#46; To compare numerical variables between the two groups&#44; the Mann-Whitney test was used&#59; to compare proportions&#44; the chi-squared test or Fisher&#39;s exact test were used&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the statistical analysis&#44; p-values were obtained using Fisher&#39;s exact test &#40;for groups with n &#8804; 5&#41; and the chi-squared test&#44; both two-tailed&#46; The recurrence-free time was analyzed using Kaplan-Meier survival curves and the groups were compared using the log-rank test&#46; All analyses considered the level of statistical significance within a confidence interval of p&#8239;&#60;&#8239;0&#46;05&#46; The SAS System for Windows &#40;Statistical Analysis System &#8211; v&#46; 9&#46;4&#46; SAS Institute Inc&#46;&#44; 2002&#8211;2008&#44; Cary&#44; NC&#44; United States&#41; was used for statistical analysis&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Results</span><p id="par0075" class="elsevierStylePara elsevierViewall">The study included 120 patients&#44; with a mean age of 69&#46;6 years and a median of 71&#46;5 years&#44; ranging from 31 to 100 years&#46; There were 60 male patients &#40;50&#37;&#41; and 60 female patients &#40;50&#37;&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Regarding the location of the lesions&#44; the highest incidence of tumor was in the nasal area&#44; in 34 patients &#40;28&#46;33&#37;&#41;&#44; followed by periocular &#40;22 patients&#59; 18&#46;3&#37;&#41; and malar &#40;13 patients&#59; 10&#46;8&#37;&#41; regions&#46; Only 13 of the 120 patients &#40;10&#46;8&#37;&#41; had a tumor outside the face&#44; as shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; As for the ethnicity of the patients analyzed&#44; only one patient was mixed-race &#40;0&#46;8&#37;&#41;&#44; while 119 were white &#40;99&#46;2&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The histological types found overlapped&#44; with the same tumor showing different histological patterns&#44; totaling 228 occurrences&#46; These were grouped into nodular&#44; superficial&#44; sclerosing&#44; micronodular&#44; and keratotic&#46; The four main patterns found were&#58; nodular &#40;83&#46;33&#37; of tumors&#41;&#44; sclerosing &#40;54&#46;17&#37;&#41;&#44; superficial &#40;31&#46;67&#37;&#41;&#44; and micronodular &#40;18&#46;33&#37;&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#44; in absolute values and percentages&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The mean tumor size was 1&#46;1&#8239;cm and the median was 0&#46;8&#8239;cm&#44; the smallest measuring 0&#46;3&#8239;cm and the largest&#44; 5&#46;2&#8239;cm&#46; The charts of only 50 patients presented a description of tumor size&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The compromised margin with the highest incidence was the lateral margin&#44; in 63 excisions &#40;52&#46;5&#37;&#41;&#59; the deep margin was compromised in 13 &#40;10&#46;8&#37;&#41;&#59; 38 patients presented both the deep and lateral margins compromised &#40;31&#46;7&#37;&#41;&#46; Of the 120 anatomopathological reports&#44; 114 specified the compromised margin&#44; as shown in <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Of the 120 patients&#44; 73 &#40;60&#46;8&#37;&#41; underwent clinical follow-up of the compromised margins&#44; while 40 &#40;33&#46;3&#37;&#41; underwent re-excision&#46; The remaining seven underwent non-surgical treatments&#58; four underwent radiotherapy&#44; two underwent cryosurgery&#44; and one was treated with topical imiquimod &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Of the 40 patients who underwent re-excision&#44; conventional surgery was performed in 30 &#40;75&#37;&#41;&#44; while ten &#40;25&#37;&#41; underwent Mohs micrographic surgery&#46; Among these 40 patients&#44; 23 &#40;57&#46;5&#37;&#41; presented residual tumor <span class="elsevierStyleItalic">vs</span>&#46; 17 &#40;42&#46;5&#37;&#41; without residual tumor&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Frequencies of recurrence were compared&#44; considering the following as independent variables&#58; age&#44; sex&#44; location&#44; tumor size&#44; type of affected margin&#44; type of follow-up &#40;observation or re-excision&#41;&#44; type of re-excision &#40;conventional or Mohs&#41;&#44; and presence or absence of residual tumor&#46; The frequencies for each histological pattern were not compared due to the overlap of different subtypes in the same tumor&#46; The association between tumor factors is shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">The mean age of patients who did not present recurrence was 70&#46;4 years and the median was 71&#46;5 years &#40;ranging from 37 to 100&#41;&#44; whereas the mean age of those who presented recurrence was 67&#46;6 years and the median&#44; 71&#46;5 years &#40;ranging from 31 to 85&#41;&#46; No statistically significant difference was observed between the groups&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A higher number of recurrences &#40;55&#46;9&#37;&#41; was observed in the female patients when compared with the males &#40;44&#46;1&#37;&#41;&#44; but the difference was not statistically significant&#46; The mixed-race patient did not present recurrence&#44; and it was therefore not possible to calculate the p-value&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Of the total of 120 cases of incomplete BCC excision&#44; 86 did not show recurrence&#44; <span class="elsevierStyleItalic">vs&#46;</span> 34 cases of recurrence&#46; Regarding the location of the tumor&#44; the malar region did not present any cases of recurrence&#44; a statistically significant difference &#40;p&#8239;&#60;&#8239;0&#46;05&#41;&#59; in turn&#44; the difference for other regions was not statistically significant&#46; Ten cases in the auricular or periauricular region did not present recurrence &#40;11&#46;6&#37;&#41;&#44; which was observed in two cases &#40;5&#46;9&#37;&#41;&#46; A total of 16 cases in the periocular region did not show recurrence &#40;18&#46;6&#37;&#41;&#44; which was observed in six cases &#40;17&#46;6&#37;&#41;&#46; Two cases in the forehead did not show recurrence &#40;2&#46;3&#37;&#41;&#44; which was observed in four cases &#40;11&#46;8&#37;&#41;&#46; The mandibular region presented three cases &#40;8&#46;8&#37;&#41; of recurrence and three cases with no recurrence &#40;3&#46;5&#37;&#41;&#46; The temporal region presented only one case of recurrence &#40;2&#46;9&#37;&#41;&#44; which was not observed in the remaining five cases &#40;5&#46;8&#37;&#41;&#46; Three &#40;3&#46;5&#37;&#41; cases in the nasolabial groove did not show recurrence&#44; observed in two cases &#40;5&#46;9&#37;&#41;&#46; Of the three cases in the labial region&#44; two did not recur &#40;2&#46;3&#37;&#41;&#44; while one did &#40;2&#46;9&#37;&#41;&#46; Outside the face&#44; there were four cases &#40;11&#46;7&#37;&#41; of recurrences and nine &#40;10&#46;5&#37;&#41; did not recur&#59; the nasal region presented the highest number of recurrences&#44; 11 &#40;32&#46;4&#37;&#41;&#44; while 23 cases &#40;26&#46;7&#37;&#41; did not present recurrences&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">There are studies claiming that BCC aggressiveness is related to larger lesion diameters and subclinical extension&#44; so the present authors decided to analyse the scarce data on mean lesion size &#40;n&#8239;&#61;&#8239;50&#41;&#46; Among patients who did not have recurrence&#44; the mean lesion size was 1&#46;0&#8239;cm and the median was 0&#46;8&#8239;cm &#40;0&#46;3&#8211;2&#46;5&#41;&#44; while in those who had recurrence the mean size was 1&#46;5&#8239;cm and the median was 0&#46;9&#8239;cm &#40;0&#46;3&#8211;5&#46;2&#41;&#59; however&#44; this difference was not statistically significant&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">No difference was found in recurrence regarding the type of affected margin&#58; lateral&#44; deep&#44; or both&#46; Regarding the type of follow-up&#44; despite the apparently higher proportion of recurrences in patients who underwent clinical follow-up when compared with those who underwent a second surgery &#40;32&#46;9&#37; <span class="elsevierStyleItalic">vs&#46;</span> 20&#37; respectively&#41;&#44; the difference between the two approaches was not statistically significant&#46; There was also no difference between the types of second surgery &#40;conventional or Mohs&#41; or the presence or absence of residual tumor&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Of the 120 patients&#44; 34 presented recurrence and 86 remained tumor-free&#44; which indicates a final tumor recurrence rate of 28&#46;3&#37;&#46; The mean follow-up time was 29&#46;54 months&#44; with a standard deviation of 23&#46;07 months&#46; The median was 25 months&#44; ranging from 3 to 112 months&#44; which indicates that half of the patients were followed-up for over two years&#46; No statistically significant difference &#40;p&#8239;&#61;&#8239;0&#46;251&#41; was observed in the recurrence-free time in patients who were clinically followed-up&#44; those who underwent re-excision&#44; and those who underwent other treatments&#46; The Kaplan-Meier survival analysis for recurrence is shown in <a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">The factors studied were related to the time that each patient remained free of tumor recurrence&#44; and no statistically significant difference was observed in disease-free time in relation to any of the factors studied&#44; except for patients with tumor in the malar region &#40;p&#8239;&#61;&#8239;0&#46;026&#59; <a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discussion</span><p id="par0150" class="elsevierStylePara elsevierViewall">The mean age of the patients with a compromised margin was compatible with the findings of other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;24</span></a> The data demonstrate that&#44; in general&#44; the lesions appear initially after the sixth decade of life&#44; despite the occurrence of cases diagnosed before the age of 30&#46; However&#44; cases with a compromised margin tend to have a higher mean age&#44; ranging from 66 to 74 years&#44; according to the findings in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;21&#44;25&#8211;28</span></a> Studies observed a statistically significant difference between the mean age of the group of patients who had complete excision and the group of patients with incomplete excision&#59; the second group had a higher age&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;28</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">In the present study&#44; no statistically significant difference was observed in the age of presentation between men and women&#44; and incomplete excisions did not occur preferentially in a given sex&#46; However&#44; another study pointed out that women may have more compromised margins than men due to undergoing more conservative surgeries&#44; for better esthetic results&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Most tumors observed in this study were less than 2&#8239;cm&#44; denoting patients&#39; demand for care and a correct and early diagnosis&#44; as observed in other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;27</span></a> Despite the controversial influence of tumor size on recurrence rates&#44; data from the literature demonstrate that there is a wide variation in subclinical extent in terms of tumor diameter&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a> Another important aspect that can be defined based on the size of the lesion is the surgical margin&#46; Studies indicate that a margin of 4&#8239;mm is adequate to eradicate primary BCC lesions smaller than 2&#8239;cm in diameter&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">The nasal region is the one with the most frequently compromised margins &#40;28&#37;&#41;&#44; followed by the periocular region &#40;18&#37;&#41;&#46; Authors cite a rate of positive margins ranging from 14&#37; to 40&#37; in the nasal region and from 11&#37; to 85&#37; in the periocular region&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;21&#44;27&#44;30</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> The reason for the greater number of incompletely excised BCCs in these regions may be the result of inadequate margins for better esthetic results in these locations&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">Regarding histopathology&#44; there was an overlap of different histological subtypes&#58; the nodular type had the highest incidence &#40;83&#46;33&#37;&#41;&#44; followed by sclerosing &#40;54&#46;17&#37;&#41;&#44; superficial &#40;31&#46;67&#37;&#41;&#44; micronodular &#40;18&#46;33&#37;&#41;&#44; and keratotic &#40;2&#46;5&#37;&#41;&#46; This finding is consistent with the literature&#44; in which nodular BCC is the most commonly reported clinical variant&#44; with an incidence greater than 85&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;32&#8211;35</span></a> No statistically significant difference was observed between the histopathological subtype and recurrence&#44; although most references emphasize that tumors with a more aggressive histological subtype are associated with a higher incidence of recurrence&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">In most studies&#44; the lateral margin was the most compromised&#44; similar to what was in found the present study&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;21&#44;27&#44;30</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> This could be explained by the subclinical extent of the lesions&#44; surgeries in areas with anatomical restrictions&#44; and by the surgeon&#39;s natural tendency to preserve tissue more laterally than deeply&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;31&#44;37</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">In the period considered by this study&#44; the preferred approach was clinical follow-up &#40;60&#46;8&#37;&#41; instead re-excision &#40;33&#46;3&#37;&#41; and other treatments &#40;5&#46;8&#37;&#41;&#46; Some authors advocate re-excision in most cases with a positive margin&#44; while others suggest re-excision for only recurrent cases and aggressive subtypes&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;37</span></a> Another group of authors advocates a conservative approach&#44; especially in patients with multiple comorbidities&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">The adoption of an expectant follow-up may be acceptable in some cases of positive surgical margins&#44; such as after excision of BCC in low-risk locations &#40;trunk&#44; extremities&#44; scalp and malar region&#41;&#44; for histopathological subtypes of less aggressiveness&#44; and in patients with advanced age or comorbidities&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;30&#44;38</span></a> However&#44; incomplete BCC excision&#44; especially on the face&#44; can result in greater morbidity if the follow-up is observational&#44; as recurrence may require a more extensive surgical procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> It must also be considered that incomplete excision implies an increase in the demand for specialized care services and in the costs of a second procedure&#44; which is generally more complex&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;26&#44;40</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">In patients in whom re-excision was the adopted follow-up&#44; the presence of residual tumor was observed in 57&#46;5&#37; of re-excisions&#46; Such incidence is consistent with the literature&#44; comparable to that obtained by Masud et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> of 62&#46;9&#37;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">The total recurrence found after incomplete tumor excision was 28&#46;3&#37;&#46; Most studies reported higher values&#44; ranging from 38&#37; to 46&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;41&#8211;43</span></a> However&#44; other authors observed a recurrence rate of 25&#37;&#44; attributing this occurrence to a shorter follow-up time than other studies&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> One study found that 82&#37; of the recurrences occurred in the first five years&#44; and only about 30&#37; of cases were diagnosed in the first year of follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> It is also estimated that excision of BCC without margin control may result in a five-year recurrence rate of 3&#46;2&#37;&#8211;10&#46;0&#37; for primary BCC and 12&#46;1&#37;&#8211;17&#37; for recurrent BCC&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#44;43&#8211;45</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">Then&#44; a limitation of the present study may be the duration of the follow-up period &#40;median of two years&#41;&#46; The recommended follow-up for recurrence is five years&#59; consultations should be held every three months during the first year and then every six months&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">The mean age among the 34 patients who presented tumor recurrence was 67&#46;6 years&#44; while that of the 86 patients who did not show recurrence was 70&#46;4 years&#59; this difference was not statistically significant&#46; Furthermore&#44; no difference was observed in age between the three groups&#44; in contrast to the findings in the literature&#44; which found a higher mean age in the group of patients who underwent re-excision&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Factors such as sex and variables inherent to the tumor or to the surgical technique were not significantly associated with greater tumor recurrence&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">In order to decrease the number of incomplete excisions&#44; a peritumoral margin of at least 4&#8239;mm of clinically normal skin is the standard for conventional surgical excision of BCCs&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39&#44;41</span></a> However&#44; cure rates may decline in cases of larger tumors &#40;&#62; 2&#8239;cm&#41;&#44; aggressive histological subtypes&#44; and tumors in specific locations&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In the present study&#44; almost all recurrences &#40;approximately 83&#37;&#41; occurred in cosmetically noble areas&#44; where the peripheral margin may have been smaller&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Regarding tumor location&#44; most BCCs with compromised margins are located on the head and neck&#59; the nasal and periocular regions are the places where recurrent tumors are most frequently located&#44; followed by the periauricular region&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;25&#44;37</span></a> In agreement with the literature&#44; it was observed that the highest rate of recurrence was in the nasal &#40;32&#46;4&#37;&#41;&#44; periocular &#40;17&#46;6&#37;&#41;&#44; and periauricular &#40;11&#46;6&#37;&#41; regions&#46; A published meta-analysis on this subject found a 2&#46;24 higher relative risk of positive margins for BCCs in the nasal and periauricular region than in the rest of the body&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> This occurrence could be justified by the fact that these regions are cosmetically noble&#44; which would hinder the choice of the appropriate margin&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0220" class="elsevierStylePara elsevierViewall">No association was observed with the regions with the highest incidence of recurrence&#46; The only factor that showed a significant association with a lower chance of recurrence was the malar location&#44; where there were no cases of recurrence &#40;p&#8239;&#60;&#8239;0&#46;05&#41;&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Regarding the management in relation to the compromised margins&#44; the main objective of this study&#44; a total recurrence rate of 32&#46;9&#37; was found in patients with clinical follow-up&#44; 28&#46;6&#37; of those who underwent other treatments&#44; and 20&#37; in those who underwent re-excision&#44; which could suggest greater success of the surgical approach over the other approaches when disregarding the follow-up time&#59; however&#44; the p-value of 0&#46;14 indicates that the difference was not statistically significant&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Large tumors &#40;greater than 0&#46;8&#8239;cm&#41; and only deep margins &#40;38&#46;5&#37;&#41; presented more cases of recurrence&#44; but without statistical significance&#46; A pioneering study by Wetzel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> indicates that BCCs of any subtype with aggressive histological characteristics have a greater depth of invasion&#44; statistically significant&#44; when compared with non-aggressive BCCs&#44; a factor that may justify the incidence of recurrence in patients with deep compromised margins&#46; According to these authors&#44; the median depth of invasion of all BCCs&#44; regardless of other histopathological characteristics and subtype&#44; was 0&#46;79&#8239;mm&#44; ranging from 0&#46;10 to 5&#46;49&#8239;mm&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">These findings may explain the high rate of recurrence when the type of follow-up adopted was &#8220;other treatments&#46;&#8221; In any topical therapy&#44; the adequate penetration of a drug to its target can be a concern with agents such as imiquimod&#59; similar concern can be raised for determining the prescribed dose of radiotherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a></p><p id="par0240" class="elsevierStylePara elsevierViewall">Higher proportions of recurrences were also observed for conventional surgery when compared with the Mohs technique&#46; All of these characteristics that potentially indicate a higher risk were consistent with other studies on CBC recurrence&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;41&#8211;43</span></a> However&#44; this higher risk is considered only potential because&#44; while many of these characteristics were shown in other studies as being associated with higher rates of recurrence&#44; in the present study the statistical analyses failed to reach statistical significance&#59; therefore&#44; the higher risk cannot be considered proven&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">These results considered the surgeon&#39;s medical specialty&#58; only patients whose BCCs were excised by dermatologists were included&#46; This differentiation is quite common in other clinical studies in which surgical intervention is considered&#46; Ramdas et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> concluded that BCCs were more often excised with free margins by dermatologists &#40;93&#37;&#41; than by plastic surgeons &#40;83&#37;&#41; and general surgeons &#40;70&#37;&#41;&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">If the type of follow-up chosen for the patient with a positive margin is clinical observation&#44; it is necessary to educate the patient about the possibilities of active prophylaxis against BCC&#44; especially in relation to sun protection&#46; Furthermore&#44; it is also necessary to inform the patient about the need for self-examination of the skin&#46; This is of particular importance not only for monitoring recurrence&#44; but also for the risk of developing another BCC&#44; which is ten times higher in patients with previous BCC than in the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> This risk is also significantly higher in elderly patients&#44; in patients with multiple BCCs&#44; and those with lesions with a diameter greater than 1&#8239;cm&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">This study&#44; in line with global algorythms&#44; reiterates the quality of care and treatment offered to patients with BCC in a tertiary hospital&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclusions</span><p id="par0260" class="elsevierStylePara elsevierViewall">The presence of positive margins in the histopathological examination of the tumor does not necessarily imply recurrence&#46; However&#44; an individualized approach is recommended in such cases&#46; Several factors must be considered &#8211; particularly tumor location&#44; presence of multiple tumors&#44; and histopathological characteristics &#8211; before selecting the best treatment option&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Regarding the conduct adopted in relation to compromised margins&#44; 32&#46;9&#37; of recurrence was observed in patients who were clinically followed-up&#44; <span class="elsevierStyleItalic">vs&#46;</span> 20&#37; in those who underwent re-excision&#46; Considering the anatomical location&#44; the present study showed a significant association with a lesser chance of recurrence and a longer time until recurrence in the malar region&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">The present data offer new elements for the proper management of patients who present a compromised margin after surgical excision&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Financial support</span><p id="par0280" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Authors&#8217; contributions</span><p id="par0285" class="elsevierStylePara elsevierViewall">Maria Carolina Fidelis&#58; Drafting and editing of the manuscript&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Rafael Fantelli Stelini&#58; Collection&#44; analysis&#44; and interpretation of data&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Leonardo Piropo Staffa&#58; Collection&#44; analysis&#44; and interpretation of data&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">Aparecida Machado de Moraes&#58; Intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">Renata Ferreira Magalh&#227;es&#58; Effective participation in research orientation&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0310" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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    "fechaRecibido" => "2020-01-16"
    "fechaAceptado" => "2020-05-09"
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            1 => "Carcinoma&#44; basal cell"
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    "resumen" => array:1 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Non-melanoma skin cancer is the most common type of malignancy in the Western world&#44; and surgical excision is the preferred approach&#46; The approach adopted in the face of incomplete excisions of basal cell carcinoma is still controversial&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">To compare the number of tumor recurrences after treatment for incompletely excised basal cell carcinoma&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Selection and statistical analysis of medical records of patients who had compromised margins after excision of basal cell carcinoma in a tertiary hospital from 2008 to 2013&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">A total of 120 medical records were analyzed&#59; the mean age was 69&#46;6 years&#44; and 50&#37; of the patients were female&#46; The most prevalent histological type was nodular&#59; the mean size was 1&#46;1&#8239;cm&#44; and the tumor location with the highest incidence was the nose&#46; The lateral margin was the most frequently positive&#46; Clinical follow-up was more widely adopted&#59; only 40 patients underwent a second surgery&#46; The total number of patients who had tumor recurrence was 34 &#40;28&#46;3&#37;&#41;&#46; Only the malar location significantly influenced the incidence of recurrence &#40;p&#8239;&#61;&#8239;0&#46;02&#41;&#46; The mean follow-up time was 29&#46;54 months&#44; with no significant difference between the follow-ups&#44; although 32&#46;9&#37; of the patients followed-up clinically showed recurrence&#44; against only 20&#37; of those who underwent a second surgery&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Study limitations</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Mean follow-up time of less than five years and sample size&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusions</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">The presence of compromised margins does not necessarily imply recurrence&#46; Location&#44; tumor size&#44; histological subtype&#44; previous epithelial tumors&#44; and clinical conditions of the patient must be considered when choosing the best treatment option&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Study conducted at the Department of Dermatology&#44; Hospital das Cl&#237;nicas&#44; Universidade Estadual de Campinas&#44; Campinas&#44; SP&#44; Brazil&#46;</p>"
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                  \t\t\t\t">Mean&#8239;&#177;&#8239;SD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">67&#46;6&#8239;&#177;&#8239;13&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">69&#46;6&#8239;&#177;&#8239;13&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">N&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Median &#40;min&#8211;max&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">71&#46;5 &#40;31&#46;0&#8211;85&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Forehead&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Mandibular&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;3497<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Temporal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5139<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nasolabial groove&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5211<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lip&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">33&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0000<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outside the face&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;8562<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Size &#40;cm&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mean&#8239;&#177;&#8239;SD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1932<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Median &#40;min&#8211;max&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9 &#40;0&#44;3&#8211;5&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8 &#40;0&#44;3&#8211;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8 &#40;0&#44;3&#8211;5&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Compromised margin</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lateral&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4453<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Deep&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lateral and deep&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No information&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Type of follow-up</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clinical observation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;3481<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Re-excision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Other treatments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Type of re-excision</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Conventional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0000<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mohs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Residual tumor</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Present&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0000<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">N&#47;A&nbsp;\t\t\t\t\t\t\n
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