Case Letter
Dermoscopy of late-onset nevus comedonicus
Lido
6474
Vezesque se leu este artigo
3041
Total PDF
3433
Total HTML
Compartilhar estatÃsticas
array:24 [ "pii" => "S0365059620302245" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.03.018" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "261" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2020" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275220303027" "issn" => "26662752" "doi" => "10.1016/j.abdp.2020.09.014" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "261" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta – Caso clínico</span>" "titulo" => "Dermatoscopia de nevo comedônico de início tardio" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "773" "paginaFinal" => "775" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 489 "Ancho" => 850 "Tamanyo" => 63782 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Placa ceratótica e pequeno nódulo em forma de comedo na panturrilha esquerda, seguindo uma linha de Blaschko.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cesare Massone, Sanja Javor, Simona Sola" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Cesare" "apellidos" => "Massone" ] 1 => array:2 [ "nombre" => "Sanja" "apellidos" => "Javor" ] 2 => array:2 [ "nombre" => "Simona" "apellidos" => "Sola" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059620302245" "doi" => "10.1016/j.abd.2020.03.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620302245?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303027?idApp=UINPBA00008Z" "url" => "/26662752/0000009500000006/v1_202012150903/S2666275220303027/v1_202012150903/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059620302178" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.03.014" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "254" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Squamous cell carcinoma superimposed on necrobiosis lipoidica: a rare complication" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "775" "paginaFinal" => "777" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1202 "Ancho" => 905 "Tamanyo" => 75112 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Small hyperkeratotic ulcerated plaque on a necrobiosis lipoidica lesion.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maria Emilia Vieira de Souza, Julia Kanaan Recuero, Manoella Freitas Santos, Renan Rangel Bonamigo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Maria Emilia Vieira de" "apellidos" => "Souza" ] 1 => array:2 [ "nombre" => "Julia Kanaan" "apellidos" => "Recuero" ] 2 => array:2 [ "nombre" => "Manoella Freitas" "apellidos" => "Santos" ] 3 => array:2 [ "nombre" => "Renan Rangel" "apellidos" => "Bonamigo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220302952" "doi" => "10.1016/j.abdp.2020.09.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302952?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620302178?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000006/v2_202011230629/S0365059620302178/v2_202011230629/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059620302166" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.02.014" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "253" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Multiple seborrheic keratoses in a previously irradiated site" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "771" "paginaFinal" => "773" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 959 "Ancho" => 905 "Tamanyo" => 91352 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Detail of multiple brownish, rounded, well-defined papules with a greasy surface, restricted to the left breast.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Danielle Ferreira Chagas, Lúcia Martins Diniz, Bruna Anjos Badaró, Elton Almeida Lucas" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Danielle Ferreira" "apellidos" => "Chagas" ] 1 => array:2 [ "nombre" => "Lúcia Martins" "apellidos" => "Diniz" ] 2 => array:2 [ "nombre" => "Bruna Anjos" "apellidos" => "Badaró" ] 3 => array:2 [ "nombre" => "Elton Almeida" "apellidos" => "Lucas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220302940" "doi" => "10.1016/j.abdp.2020.09.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302940?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620302166?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000006/v2_202011230629/S0365059620302166/v2_202011230629/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Dermoscopy of late-onset nevus comedonicus" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "773" "paginaFinal" => "775" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cesare Massone, Sanja Javor, Simona Sola" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Cesare" "apellidos" => "Massone" "email" => array:1 [ 0 => "cesare.massone@galliera.it" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Sanja" "apellidos" => "Javor" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Simona" "apellidos" => "Sola" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Dermatology Unit, Galliera Hospital, Genova, Italy" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Surgical Pathology, Galliera Hospital, Genova, Italy" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 523 "Ancho" => 905 "Tamanyo" => 71385 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Keratotic plaque and small comedo-like nodule on the left calf following a Blaschko line.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Nevus comedonicus (NC) is a rare hamartoma of the pilosebaceous unit, a subtype of epidermal nevus first described by Kofmann in 1895.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> NC manifests with linear or grouped papules and dilated follicular openings with keratotic plugs (resembling comedones) particularly on the face, trunk, and neck; in 50% of cases, it is present at birth, but can also develop during childhood (most commonly before the age of 10 years). The rare presence of skeletal and neurological abnormalities describes the nevus comedonicus syndrome.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Histopathology shows keratin-filled invaginations of the epidermis, with absent or rudimentary sebaceous glands. Inflammation and subsequent dermal infiltrate have been described in some cases.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Rarely, NC may present in adults;recently Zaniello et al., reporting an additional case of late-onset NC, reviewed the few cases described.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 72-year-old man with a previous history of stage IB cutaneous melanoma on the trunk in 2013 and prostate carcinoma presented in June 2019 with a keratotic plaque (2 × 1 cm in diameter) and a small comedo-like nodule (almost 1 cm in diameter) on the left calf, following a Blaschko line (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The lesions had appeared almost 25 years before, and the patient had been asymptomatic until the week before, when the lesions became very itchy. Dermoscopic examination showed a central keratotic plug surrounded by a white structureless area with scales and focal pale structureless red area without clear vessels (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The patient had been taking candesartan, hydrochlorothiazide, bicalutamide, simvastatine, and rabepreazole for years. General physical and neurological examinations were normal, and the patient denied a family history of analogous lesions. Histopathology demonstrated a cyst-dilated follicular opening filled with keratin, slight acanthosis of the epidermis, and hyperkeratosis with ortho- and parakeratosis. The follicular epithelial wall and the epidermis showed EHK with hypereosinophilic keratohyalin granules in the granular cell layer and perinuclear vacuolization (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Sebaceous and eccrine glands were not present. A focal discrete lymphohistiocytic infiltrate was present in the papillary dermis. Upon clinicopathologic correlation, the diagnosis of late-onset NC with EHK was made. The main differential diagnosis was inflammatory linear verrucous epidermal nevus (ILVEN), which typically presents in the first 6 months of life as a pruritic linear eruption on the lower limbs, arranged along the Blaschko lines. At histopathology, ILVEN shows psoriasiform epidermal hyperplasia with parakeratosis, alternating with orthokeratosis. Beneath the orthokeratosis, hypergranulosis is observed, while the parakeratosis overlies areas of agranulosis. Focal mild spongiosis with some exocytosis and even vesiculation may be present, together with a mild perivascular lymphocytic infiltrate in the upper dermis.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The infiltrate observed in the present case was probably caused by irritation. EHK is characterized by compact hyperkeratosis with granular and vacuolar degeneration of the cells of the spinous and granular layers. It may be an incidental finding or may be observed in different settings, such as bullous ichthyosis, epidermal nevi variant, palmoplantar keratoderma variant, or disseminated epidermolytic acanthoma.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">EHC in a NC has been reported in few cases in the literature reviewed by Zanniello et al.,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> who reported a peculiar case with late onset (55-year old woman). The present patient is an additional case of this rare histopathological variant of NC.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Dermoscopy of NC was reported in detail for only two young patients. Vora et al. described multiple, well-defined, structureless brown homogenous circular areas surrounding the keratin plugs.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Kamińska-Winciorek et al. reported numerous circular and barrel-shaped, homogenous areas in light and dark-brown shades, with remarkable keratin plugs.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the present case, a central keratotic plug was observed, surrounded by a white structureless area with scales and focal pale structureless red area without clear vessels. The following dermoscopic differential diagnoses were considered for the present case: squamous cell carcinoma/keratoacanthoma, which shows an amorphous, yellow-white central mass of keratin, hairpin vessels, and/or serpentine vessels; common wart, which at dermoscopy presents multiple densely packed papillae, with a central red dot or loop, surrounded by a whitish halo; molluscum contagiosum, which displays a central pore in association with polylobular white-to-yellow amorphous structures, surrounded by blurred telangiectasia.</p><p id="par0025" class="elsevierStylePara elsevierViewall">A topical treatment with methylprednisolone aceponate 0.1% for on week and urea 10% ointment twice a day as maintenance therapy was prescribed, with fast improvement of the pruritus and slight decrease of keratotic component.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors' contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">Cesare Massone: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sanja Javor: Approval of the final version of the manuscript; drafting and editing of the manuscript; collection, analysis, and interpretation of data; critical review of the literature; critical review of the manuscript.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Simona Sola: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors' contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-12-21" "fechaAceptado" => "2020-03-04" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0001">How to cite this article: Massone C, Javor S, Sola S. Dermoscopy of late-onset nevus comedonicus. An Bras Dermatol. 2020. <span class="elsevierStyleInterRef" id="intr0001" href="https://doi.org/10.1016/j.abd.2020.03.018">https://doi.org/10.1016/j.abd.2020.03.018</span></p>" ] 1 => array:2 [ "etiqueta" => "⋆⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Galliera Hospital, Genoa, Italy.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 523 "Ancho" => 905 "Tamanyo" => 71385 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Keratotic plaque and small comedo-like nodule on the left calf following a Blaschko line.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 817 "Ancho" => 905 "Tamanyo" => 115611 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic examination showed a central keratotic plug surrounded by a white structureless area with scales and focal pale structureless red area without clear vessels.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 715 "Ancho" => 1305 "Tamanyo" => 149573 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cyst-dilated follicular opening filled with keratin, slight acanthosis of the epidermis, hyperkeratosis with ortho- and parakeratosis. The epithelial wall and the epidermis showed epidermolytic hyperkeratosis (Hematoxylin & eosin, ×20).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevus comedonicus: a case series" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Ferrari" 1 => "V. Taliercio" 2 => "P. Restrepo" 3 => "P. Luna" 4 => "M.E. Abad" 5 => "M. Larralde" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/pde.12466" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol." "fecha" => "2015" "volumen" => "32" "paginaInicial" => "216" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25557057" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Weedon’s skin pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Weedon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "3<span class="elsevierStyleSup">rd</span> ed" "fecha" => "2009" "editorial" => "Churchill Livingstone" "editorialLocalizacion" => "London" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late-onset nevus comedonicus with follicular epidermolytic hyperkeratosis-case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Zanniello" 1 => "L. Pilloni" 2 => "B. Conti" 3 => "G. Faa" 4 => "F. Rongioletti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0000000000001317" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol." "fecha" => "2019" "volumen" => "41" "paginaInicial" => "453" "paginaFinal" => "455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30461425" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermoscopy of nevus comedonicus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.V. Vora" 1 => "R.S. Kota" 2 => "N.K. Sheth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Indian Dermatol Online." "fecha" => "2017" "volumen" => "8" "paginaInicial" => "388" "paginaFinal" => "389" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermoscopy on nevus comedonicus: a case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Kamińska-Winciorek" 1 => "R. Spiewak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5114/pdia.2013.37036" "Revista" => array:6 [ "tituloSerie" => "Postepy Dermatol Alergol." "fecha" => "2013" "volumen" => "30" "paginaInicial" => "252" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24278083" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009500000006/v2_202011230629/S0365059620302245/v2_202011230629/en/main.assets" "Apartado" => array:4 [ "identificador" => "82769" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Letter" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000006/v2_202011230629/S0365059620302245/v2_202011230629/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620302245?idApp=UINPBA00008Z" ]
| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 27 | 11 | 38 |
| 2024 Outubro | 94 | 71 | 165 |
| 2024 Setembro | 163 | 102 | 265 |
| 2024 Agosto | 162 | 116 | 278 |
| 2024 Julho | 157 | 119 | 276 |
| 2024 Junho | 122 | 94 | 216 |
| 2024 Maio | 138 | 69 | 207 |
| 2024 Abril | 120 | 98 | 218 |
| 2024 Março | 99 | 71 | 170 |
| 2024 Fevereiro | 105 | 89 | 194 |
| 2024 Janeiro | 75 | 55 | 130 |
| 2023 Dezembro | 78 | 77 | 155 |
| 2023 Novembro | 83 | 79 | 162 |
| 2023 Outubro | 78 | 89 | 167 |
| 2023 Setembro | 77 | 73 | 150 |
| 2023 Agosto | 72 | 40 | 112 |
| 2023 Julho | 60 | 32 | 92 |
| 2023 Junho | 61 | 45 | 106 |
| 2023 Maio | 49 | 19 | 68 |
| 2023 Abril | 47 | 19 | 66 |
| 2023 Março | 63 | 49 | 112 |
| 2023 Fevereiro | 42 | 33 | 75 |
| 2023 Janeiro | 57 | 34 | 91 |
| 2022 Dezembro | 52 | 20 | 72 |
| 2022 Novembro | 96 | 59 | 155 |
| 2022 Outubro | 119 | 59 | 178 |
| 2022 Setembro | 49 | 63 | 112 |
| 2022 Agosto | 42 | 62 | 104 |
| 2022 Julho | 43 | 64 | 107 |
| 2022 Junho | 49 | 67 | 116 |
| 2022 Maio | 48 | 65 | 113 |
| 2022 Abril | 45 | 50 | 95 |
| 2022 Março | 36 | 71 | 107 |
| 2022 Fevereiro | 40 | 50 | 90 |
| 2022 Janeiro | 57 | 73 | 130 |
| 2021 Dezembro | 32 | 57 | 89 |
| 2021 Novembro | 28 | 55 | 83 |
| 2021 Outubro | 47 | 84 | 131 |
| 2021 Setembro | 29 | 57 | 86 |
| 2021 Agosto | 34 | 55 | 89 |
| 2021 Julho | 44 | 60 | 104 |
| 2021 Junho | 25 | 45 | 70 |
| 2021 Maio | 75 | 59 | 134 |
| 2021 Abril | 171 | 183 | 354 |
| 2021 Março | 95 | 95 | 190 |
| 2021 Fevereiro | 34 | 19 | 53 |
| 2021 Janeiro | 57 | 23 | 80 |
| 2020 Dezembro | 24 | 23 | 47 |
| 2020 Novembro | 20 | 18 | 38 |
| 2020 Outubro | 9 | 9 | 18 |
| 2020 Setembro | 4 | 12 | 16 |
Mostrar tudo
