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preferentially situated on the buttocks and legs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This report presents the case of a previously healthy baby girl with genital EG and the subsequent development of a severe transitory neutropenia&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A previously healthy 17-month-old girl presented with a hemorrhagic blister on the left side of her vulva&#46; It had started seven days before&#44; with perilesional erythema &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; that progressively developed ulceration and edema&#46; There was no fever or other systemic symptoms&#46; She was treated with oral cefpodoxime and clindamycin&#46; As there was no improvement after 72&#8239;hours&#44; she was hospitalized and referred to dermatology&#46; On physical examination&#44; the patient was in good general condition with stable hemodynamics and no fever&#46; She had a skin ulcer on the left labia majora with a maximum diameter of 1&#46;7&#8239;cm and well-defined borders&#46; There was fibrin at its base&#44; much swelling&#44; and perilesional induration&#44; sensitive to the touch &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; A hemogram was carried out which showed 5&#44;840 leucocytes&#47;mm<span class="elsevierStyleSup">3</span>&#44; an absolute neutrophil count &#40;ANC&#41; of 876&#8239;mm<span class="elsevierStyleSup">3</span>&#44; and C-reactive protein of 33&#8239;mg&#47;dL&#46; Polymerase chain reaction &#40;PCR&#41; tests of the lesion for herpes simplex viruses 1 and 2&#44; cytomegalovirus&#44; varicella-zoster virus&#44; and the Epstein-Barr virus were all negative&#46; Blood&#44; fungal&#44; and mycobacteria cultures were all negative&#44; but a culture of the lesion tested positive for <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#46; An immunological study was made for lymphocytic sub-populations&#44; IgA-IgM-IgG immunoglobulins&#44; neutrophil oxidative burst test&#44; anti-neutrophil antibodies&#44; VDRL&#44; and HIV&#46; All these were negative&#44; thus eliminating the possibility of associated immunodeficiency&#46; After treatment with intravenous ceftazidime and amikacin for six days there was a favorable evolution&#44; so it was decided to discharge her and provide oral ciprofloxacin for 14 days&#46; This resulted in the complete resolution of the lesion&#46; At an outpatient checkup 72&#8239;hours after the discharge&#44; the hemogram showed 4&#44;800 leucocytes&#47;mm<span class="elsevierStyleSup">3</span> and an ANC of 96&#8239;mm<span class="elsevierStyleSup">3</span>&#44; which improved spontaneously after two weeks and showed no relapse after six months on follow-up&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">EG is a rare disease in healthy pediatric patients with no associated sepsis&#46; It generally reveals a primary sub-clinical immunodeficiency and so it is essential to carry out a complete immunological study on all such patients&#46; Its mortality is high&#44; over 90&#37; where there is sepsis and 15&#37; in the case of local infection&#44; where neutropenia is the most important factor for prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;4</span></a> In the literature there are few cases of EG in previously healthy patients&#59; the present authors found only six which showed severe neutropenia &#40;&#60; 500 mm<span class="elsevierStyleSup">3</span>&#41; after the initiation of the clinical condition&#44; as in this report&#46; However&#44; all these cases showed an associated etiological factor &#40;respiratory infections&#44; infantile benign neutropenia&#44; and hypogammaglobulinemia&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Leucopenia induced by fluoroquinolones has been described&#46; This tends to be mild to moderate&#44; being reported in less than 0&#46;2&#37; of the cases&#44; mainly in adults with co-morbidities&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the present case normalization of the hemogram occurred at the end of the second week of oral ciprofloxacin&#44; so this cause is not very probable&#46; Also&#44; it has been suggested that <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> might cause a transitory neutropenia mediated by a toxin that could inhibit the migration of neutrophils to the affected areas and also reduce the number of neutrophils in the blood&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This case is reported due to the exceptional manifestation of severe neutropenia after EG in an immunocompetent patient&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#39; contributions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Pablo Vargas-Mora&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Santiago Garc&#237;a&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Ligia Aranibar&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Fernando Valenzuela&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
Ecthyma gangrenosum and severe transitory neutropenia in an immunocompetent girl
Pablo Vargas-Mora
Autor para correspondência
pablovargas.med@gmail.com

Corresponding author.
, Santiago García, Ligia Aranibar, Fernando Valenzuela
Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Ecthyma gangrenosum &#40;EG&#41; is a rare cutaneous lesion&#44; principally caused by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44; through either primary infection or hematogenous spread&#46; Other pathogenic agents responsible have also been described&#44; such as <span class="elsevierStyleItalic">Aeromonas hydrophila</span>&#44; <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; and <span class="elsevierStyleItalic">Aspergillus</span> spp&#46;&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> It generally develops in patients with sepsis or immunosuppression&#44; in a context of hematological malignancies or immunosuppressive therapy&#46; It presents with erythematous&#47;violaceous or hemorrhagic lesions that evolve into a central necrotic ulcer with an erythematous halo&#44; preferentially situated on the buttocks and legs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This report presents the case of a previously healthy baby girl with genital EG and the subsequent development of a severe transitory neutropenia&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A previously healthy 17-month-old girl presented with a hemorrhagic blister on the left side of her vulva&#46; It had started seven days before&#44; with perilesional erythema &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; that progressively developed ulceration and edema&#46; There was no fever or other systemic symptoms&#46; She was treated with oral cefpodoxime and clindamycin&#46; As there was no improvement after 72&#8239;hours&#44; she was hospitalized and referred to dermatology&#46; On physical examination&#44; the patient was in good general condition with stable hemodynamics and no fever&#46; She had a skin ulcer on the left labia majora with a maximum diameter of 1&#46;7&#8239;cm and well-defined borders&#46; There was fibrin at its base&#44; much swelling&#44; and perilesional induration&#44; sensitive to the touch &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; A hemogram was carried out which showed 5&#44;840 leucocytes&#47;mm<span class="elsevierStyleSup">3</span>&#44; an absolute neutrophil count &#40;ANC&#41; of 876&#8239;mm<span class="elsevierStyleSup">3</span>&#44; and C-reactive protein of 33&#8239;mg&#47;dL&#46; Polymerase chain reaction &#40;PCR&#41; tests of the lesion for herpes simplex viruses 1 and 2&#44; cytomegalovirus&#44; varicella-zoster virus&#44; and the Epstein-Barr virus were all negative&#46; Blood&#44; fungal&#44; and mycobacteria cultures were all negative&#44; but a culture of the lesion tested positive for <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#46; An immunological study was made for lymphocytic sub-populations&#44; IgA-IgM-IgG immunoglobulins&#44; neutrophil oxidative burst test&#44; anti-neutrophil antibodies&#44; VDRL&#44; and HIV&#46; All these were negative&#44; thus eliminating the possibility of associated immunodeficiency&#46; After treatment with intravenous ceftazidime and amikacin for six days there was a favorable evolution&#44; so it was decided to discharge her and provide oral ciprofloxacin for 14 days&#46; This resulted in the complete resolution of the lesion&#46; At an outpatient checkup 72&#8239;hours after the discharge&#44; the hemogram showed 4&#44;800 leucocytes&#47;mm<span class="elsevierStyleSup">3</span> and an ANC of 96&#8239;mm<span class="elsevierStyleSup">3</span>&#44; which improved spontaneously after two weeks and showed no relapse after six months on follow-up&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">EG is a rare disease in healthy pediatric patients with no associated sepsis&#46; It generally reveals a primary sub-clinical immunodeficiency and so it is essential to carry out a complete immunological study on all such patients&#46; Its mortality is high&#44; over 90&#37; where there is sepsis and 15&#37; in the case of local infection&#44; where neutropenia is the most important factor for prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;4</span></a> In the literature there are few cases of EG in previously healthy patients&#59; the present authors found only six which showed severe neutropenia &#40;&#60; 500 mm<span class="elsevierStyleSup">3</span>&#41; after the initiation of the clinical condition&#44; as in this report&#46; However&#44; all these cases showed an associated etiological factor &#40;respiratory infections&#44; infantile benign neutropenia&#44; and hypogammaglobulinemia&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Leucopenia induced by fluoroquinolones has been described&#46; This tends to be mild to moderate&#44; being reported in less than 0&#46;2&#37; of the cases&#44; mainly in adults with co-morbidities&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the present case normalization of the hemogram occurred at the end of the second week of oral ciprofloxacin&#44; so this cause is not very probable&#46; Also&#44; it has been suggested that <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> might cause a transitory neutropenia mediated by a toxin that could inhibit the migration of neutrophils to the affected areas and also reduce the number of neutrophils in the blood&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This case is reported due to the exceptional manifestation of severe neutropenia after EG in an immunocompetent patient&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#39; contributions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Pablo Vargas-Mora&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Santiago Garc&#237;a&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Ligia Aranibar&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Fernando Valenzuela&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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