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daughter of consanguineous parents&#44; presented lesions since 2 years old&#46; The patient had no history of systemic symptoms&#44; allergies&#44; or continued use of medications&#44; except sporadic use of paracetamol&#46; In the beginning&#44; the lesions were erythematous&#44; and subsequently evolved to annular and&#47;or irregular hyperchromic macules&#44; symmetrical in the legs&#44; as well as in the right upper limb&#44; and with an isolated lesion in the anterior cervical region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; A skin biopsy of the right thigh was performed&#44; demonstrating a lichenoid lymphohistiocytic infiltrate in the upper dermis and red blood cell extravasation&#44; as well as foci of lymphocyte exocytosis and perivascular mononuclear infiltrate&#44; without pigmentary incontinence or vasculitis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Perls&#39; Prussian blue staining indicated the presence of hemosiderin deposition in the papillary dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient was screened for hematological&#44; infectious&#44; and rheumatological diseases&#44; all negative&#46; The authors opted for treatment with colchicine orally&#44; with no response after five months of medication use&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Purpura annularis telangiectodes of Majocchi is part of the pigmented purpuric dermatoses&#44; which manifests as annular macules that are symmetrical&#44; reddish-brown&#44; and generally asymptomatic&#46; It preferably affects children and young women&#44; and there is no predominant ethnicity&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> Commonly&#44; it appears in the lower limbs&#59; there appears to be an orthostatic component in the pathophysiology of the disease&#44; as described in the present case&#46; The etiology of pigmented purpuric dermatoses is not yet fully elucidated&#44; and its triggers are not always detected&#59; therefore&#44; the etiology is idiopathic in most cases&#46; An association with comorbidities such as diabetes mellitus&#44; viral hepatitis&#44; peripheral venous insufficiency&#44; and use of certain medications has been reported&#44; including the following&#58; paracetamol&#44; aspirin&#44; carbamazepine&#44; antihypertensives&#44; infliximab&#44; alpha-interferon&#44; pseudoephedrine&#44; raloxifene&#44; and thiamine&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> The present patient did not have any of the aforementioned comorbidities&#59; the sporadic use of paracetamol was the only possible trigger identified in the clinical history&#46; It is worth mentioning that most cases are idiopathic&#46; The administration of paracetamol&#44; even if occasional&#44; may have been a trigger for the clinical picture as described by Kwon et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The diagnosis of purpura annularis telangiectodes of Majocchi is clinical and histopathological&#46; The clinical characteristics are closely related to the anatomopathological findings&#46; Lesion pigmentation is due to the extravasation of red blood cells and deposition of hemosiderin seen in the papillary dermis&#46; It is also possible to observe perivascular inflammatory infiltrate composed of lymphocytes&#44; histiocytes&#44; and Langerhans cells&#46; These findings corroborate the possible association of pigmented purpuric dermatoses with cellular immunity&#44; contributing to capillary fragility&#46; Humoral immunity also appears to play a role&#44; which can be evidenced by direct immunofluorescence&#44; which can detect perivascular deposits of immunoglobulins and complement&#46; Foci of lymphocyte exocytosis may occur&#44; as observed in this case&#46; Leukocytoclastic vasculitis or epidermotropism are not observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The knowledge of this entity and its early diagnosis can allow the assessment of the presence of triggers and guide its management&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0020" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Aline Soares Garcez&#58;&#59; elaboration and writing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Vito&#769;ria Regina Pedreira de Almeida Rego&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Thadeu Santos Silva&#58; Approval of the final version of the manuscript&#59; elaboration and writing of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#44; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
Purpura annularis telangiectodes of Majocchi
Aline Soares Garceza,
Autor para correspondência
line_garcez@hotmail.com

Corresponding author.
, Vitória Regina Pedreira de Almeida Regoa, Thadeu Santos Silvab
a Dermatology Service, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
b Dermatology Service, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Purpura annularis telangiectodes of Majocchi is a rare subtype of pigmented purpuric dermatosis&#46; It is more common in children and young females and predominantly affects the lower limbs&#44; with symmetrical annular reddish-brown macules&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Little is known of its etiology&#44; which may be associated with viral infections&#44; chronic comorbidities&#44; and use of medications&#46; The diagnosis is clinical and histopathological&#46; There is no consensus regarding treatment&#46; Management is based on reports and case series&#44; with variable response to the proposed treatments&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 6-year-old female patient&#44; daughter of consanguineous parents&#44; presented lesions since 2 years old&#46; The patient had no history of systemic symptoms&#44; allergies&#44; or continued use of medications&#44; except sporadic use of paracetamol&#46; In the beginning&#44; the lesions were erythematous&#44; and subsequently evolved to annular and&#47;or irregular hyperchromic macules&#44; symmetrical in the legs&#44; as well as in the right upper limb&#44; and with an isolated lesion in the anterior cervical region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; A skin biopsy of the right thigh was performed&#44; demonstrating a lichenoid lymphohistiocytic infiltrate in the upper dermis and red blood cell extravasation&#44; as well as foci of lymphocyte exocytosis and perivascular mononuclear infiltrate&#44; without pigmentary incontinence or vasculitis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Perls&#39; Prussian blue staining indicated the presence of hemosiderin deposition in the papillary dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient was screened for hematological&#44; infectious&#44; and rheumatological diseases&#44; all negative&#46; The authors opted for treatment with colchicine orally&#44; with no response after five months of medication use&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Purpura annularis telangiectodes of Majocchi is part of the pigmented purpuric dermatoses&#44; which manifests as annular macules that are symmetrical&#44; reddish-brown&#44; and generally asymptomatic&#46; It preferably affects children and young women&#44; and there is no predominant ethnicity&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> Commonly&#44; it appears in the lower limbs&#59; there appears to be an orthostatic component in the pathophysiology of the disease&#44; as described in the present case&#46; The etiology of pigmented purpuric dermatoses is not yet fully elucidated&#44; and its triggers are not always detected&#59; therefore&#44; the etiology is idiopathic in most cases&#46; An association with comorbidities such as diabetes mellitus&#44; viral hepatitis&#44; peripheral venous insufficiency&#44; and use of certain medications has been reported&#44; including the following&#58; paracetamol&#44; aspirin&#44; carbamazepine&#44; antihypertensives&#44; infliximab&#44; alpha-interferon&#44; pseudoephedrine&#44; raloxifene&#44; and thiamine&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> The present patient did not have any of the aforementioned comorbidities&#59; the sporadic use of paracetamol was the only possible trigger identified in the clinical history&#46; It is worth mentioning that most cases are idiopathic&#46; The administration of paracetamol&#44; even if occasional&#44; may have been a trigger for the clinical picture as described by Kwon et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The diagnosis of purpura annularis telangiectodes of Majocchi is clinical and histopathological&#46; The clinical characteristics are closely related to the anatomopathological findings&#46; Lesion pigmentation is due to the extravasation of red blood cells and deposition of hemosiderin seen in the papillary dermis&#46; It is also possible to observe perivascular inflammatory infiltrate composed of lymphocytes&#44; histiocytes&#44; and Langerhans cells&#46; These findings corroborate the possible association of pigmented purpuric dermatoses with cellular immunity&#44; contributing to capillary fragility&#46; Humoral immunity also appears to play a role&#44; which can be evidenced by direct immunofluorescence&#44; which can detect perivascular deposits of immunoglobulins and complement&#46; Foci of lymphocyte exocytosis may occur&#44; as observed in this case&#46; Leukocytoclastic vasculitis or epidermotropism are not observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The knowledge of this entity and its early diagnosis can allow the assessment of the presence of triggers and guide its management&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0020" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Aline Soares Garcez&#58;&#59; elaboration and writing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Vito&#769;ria Regina Pedreira de Almeida Rego&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Thadeu Santos Silva&#58; Approval of the final version of the manuscript&#59; elaboration and writing of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#44; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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