What is your diagnosis?
Case for diagnosis. Infiltrated areas on the trunk
Larissa Daniele Machado Góesa,
, Juliana Alves Scrignolib, Patrícia Moraisc, Carolina Talharia
Autor para correspondência
a Tropical Dermatology Clinic, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil
b Rheumatology Service, Fundação Hospital Adriano Jorge, Manaus, AM, Brazil
c Dermatopathology Service, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil
Lido
5430
Vezesque se leu este artigo
2859
Total PDF
2571
Total HTML
Compartilhar estatÃsticas
array:24 [ "pii" => "S0365059620301690" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.12.007" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "224" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2020" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275220302459" "issn" => "26662752" "doi" => "10.1016/j.abdp.2020.07.004" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "224" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Qual o seu diagnóstico?</span>" "titulo" => "Caso para diagnóstico. Áreas infiltradas no tronco" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "652" "paginaFinal" => "654" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figura 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 609 "Ancho" => 905 "Tamanyo" => 55725 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Manchas hipercrômicas residuais no tronco e membros superiores após 30 dias de tratamento com poliquimioterapia e prednisona.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Larissa Daniele Machado Goes, Juliana Alves Scrignoli, Patrícia Morais, Carolina Talhari" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Larissa Daniele Machado" "apellidos" => "Goes" ] 1 => array:2 [ "nombre" => "Juliana Alves" "apellidos" => "Scrignoli" ] 2 => array:2 [ "nombre" => "Patrícia" "apellidos" => "Morais" ] 3 => array:2 [ "nombre" => "Carolina" "apellidos" => "Talhari" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059620301690" "doi" => "10.1016/j.abd.2019.12.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301690?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302459?idApp=UINPBA00008Z" "url" => "/26662752/0000009500000005/v1_202010040634/S2666275220302459/v1_202010040634/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059620301707" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.03.006" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "225" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">What is your diagnosis?</span>" "titulo" => "Case for diagnosis. Penile lesion in HIV-negative patient" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "655" "paginaFinal" => "657" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2682 "Ancho" => 1519 "Tamanyo" => 270944 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematoviolaceous papules on the corona of the glans.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mauro Cunha Ramos, Fabiana Bazanella de Oliveira, Vicente Sperb Antonello, Ana Leticia Boff" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Mauro Cunha" "apellidos" => "Ramos" ] 1 => array:2 [ "nombre" => "Fabiana Bazanella de" "apellidos" => "Oliveira" ] 2 => array:2 [ "nombre" => "Vicente Sperb" "apellidos" => "Antonello" ] 3 => array:2 [ "nombre" => "Ana Leticia" "apellidos" => "Boff" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220302460" "doi" => "10.1016/j.abdp.2020.07.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302460?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301707?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301707/v2_202011080908/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059620301689" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.02.006" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "223" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">What is your diagnosis?</span>" "titulo" => "Case for diagnosis. Subcutaneous nodules in the plantar region" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "649" "paginaFinal" => "651" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 679 "Ancho" => 905 "Tamanyo" => 204790 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Granuloma with central necrosis surrounded by a palisade of epithelioid cells (Hematoxylin & eosin, ×100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Diego Henrique Morais Silva, Isaura Azevedo Fasciani, Neusa Yuriko Sakai Valente, Bethânia Cabral Cavalli Swiczar" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Diego Henrique Morais" "apellidos" => "Silva" ] 1 => array:2 [ "nombre" => "Isaura Azevedo" "apellidos" => "Fasciani" ] 2 => array:2 [ "nombre" => "Neusa Yuriko Sakai" "apellidos" => "Valente" ] 3 => array:2 [ "nombre" => "Bethânia Cabral Cavalli" "apellidos" => "Swiczar" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220302447" "doi" => "10.1016/j.abdp.2020.07.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302447?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301689?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301689/v2_202011080908/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">What is your diagnosis?</span>" "titulo" => "Case for diagnosis. Infiltrated areas on the trunk" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "652" "paginaFinal" => "654" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Larissa Daniele Machado Góes, Juliana Alves Scrignoli, Patrícia Morais, Carolina Talhari" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Larissa Daniele Machado" "apellidos" => "Góes" "email" => array:1 [ 0 => "larissadaniele55@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Juliana Alves" "apellidos" => "Scrignoli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Patrícia" "apellidos" => "Morais" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Carolina" "apellidos" => "Talhari" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Tropical Dermatology Clinic, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Rheumatology Service, Fundação Hospital Adriano Jorge, Manaus, AM, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Dermatopathology Service, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 681 "Ancho" => 905 "Tamanyo" => 103991 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous plaques on the trunk.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 49-year-old woman reported pain in the interphalangeal joints and lower limbs, a skin rash, and alopecia; all symptoms persisted for four years. She was being treated for systemic lupus erythematosus with hydroxychloroquine, azathioprine, methotrexate, and prednisone. On physical examination, she presented generalized erythematous plaques, and infiltrated areas on the trunk, on the ears, and fingers, as well as diffuse non-healing alopecia (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">She presented 24-hour proteinuria within normal limits, positive ANA (1:320, centromeric dotted nuclear pattern), positive anti-cardiolipin IgM antibodies, and anti-SM and anti-double helix DNA, both negative.</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">What is your diagnosis?</span><p id="par0100" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a)</span><p id="par0015" class="elsevierStylePara elsevierViewall">Subacute lupus</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b)</span><p id="par0020" class="elsevierStylePara elsevierViewall">Dermatomyositis</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c)</span><p id="par0025" class="elsevierStylePara elsevierViewall">Lepromatous leprosy</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d)</span><p id="par0030" class="elsevierStylePara elsevierViewall">Diffuse eosinophilic fasciitis</p></li></ul></p><p id="par0040" class="elsevierStylePara elsevierViewall">She also presented paresthesia of the lower limbs, and thickening and pain on palpation of the left ulnar and left external sciatic popliteal nerves.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The bacilloscopy of the ear and two trunk lesions was positive (smear index: 3.33). Histopathology of the plaque in the inguinal region showed an epidermis with hyperkeratosis; in the dermis, edema and a perivascular, periadnexal, and interstitial mild inflammatory infiltrate composed of lymphocytes, histiocytes, plasmocytes, epithelioid cells, and sparse giant Langhans cells, involving the subcutaneous tissue, adipocytes and septa. Wade staining showed a large number of intracellular acid-fast bacilli, grouped in globi, fragmented and granular (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A and <a class="elsevierStyleCrossRef" href="#fig0015">3</a> B). PAS staining did not show thickening of the basal membrane, and no mucin was observed in the Alcian blue staining. In light of the histopathological alterations, a diagnosis of borderline lepromatous leprosy was made in association with type 1 lepra reaction. The patient denied having undergone previous treatment for leprosy and reported that a son-in-law had received anti-leprosy treatment. Multibacillary multidrug therapy and prednisone 60<span class="elsevierStyleHsp" style=""></span>mg/day were initiated for treating the symptoms and neural lesions. After 30 days of treatment, the patient presented significant improvement (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Leprosy is a chronic contagious infectious disease, caused by <span class="elsevierStyleItalic">Mycobacterium leprae</span>, an acid-fast bacillus, with tropism for Schwann cells and the reticuloendothelial system. The bacillus mainly affects the skin and peripheral nervous tissue.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The ability of <span class="elsevierStyleItalic">M. leprae</span> to regulate cytokine production and induce Th1 or Th2 responses contributes to the variety of clinical presentations of the disease.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Rheumatological manifestations are observed in 64% to 77% of patients with multibacillary leprosy, especially when presenting lepra reactions.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Rheumatological symptons were observed in 41.8% of the patients with lepromatous leprosy; in 23.6% of those with tuberculoid borderline; in 18.2% of those with borderline forms; and in 16.4% of those with borderline lepromatous type.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Positive ANA can be observed in 3% to 34% of leprosy patients. Titers are generally low, and the speckled and homogeneous patterns are the most common.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Rheumatoid factor, anti-CCP, ANCA, anti-cardiolipin, and antiphospholipids have been observed in varying percentages in patients with the different forms of leprosy.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–8</span></a> Non-scarring alopecia, especially in patients with the lepromatous leprosy, has already been described.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The different clinical manifestations of leprosy pose a diagnostic challenge, since they can mimic other diseases, including autoimmune disorders. The difficulty of diagnosing leprosy early can increase the chance of transmission and cause deformities secondary to peripheral nerve involvement.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors' contributions</span><p id="par0075" class="elsevierStylePara elsevierViewall">Larissa Daniele Machado Góes: Elaboration and writing of the manuscript; critical review of the literature; critical review of the manuscript.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Juliana Alves Scrignoli: Approval of the final version of the manuscript; conception and planning of the study; elaboration and writing of the manuscript; obtaining, analyzing, and interpreting the data; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Patrícia Morais: Statistical analysis; approval of the final version of the manuscript; conception and planning of the study; elaboration and writing of the manuscript; obtaining, analyzing, and interpreting the data; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Patrícia Morais: Statistical analysis; approval of the final version of the manuscript; conception and planning of the study; elaboration and writing of the manuscript; obtaining, analyzing, and interpreting the data; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:3 [ "identificador" => "xres1410361" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1290410" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "sec0005" "titulo" => "Case report" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "What is your diagnosis?" ] ] ] 3 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 4 => array:2 [ "identificador" => "sec0020" "titulo" => "Financial support" ] 5 => array:2 [ "identificador" => "sec0025" "titulo" => "Authors' contributions" ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-07-30" "fechaAceptado" => "2019-12-08" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1290410" "palabras" => array:3 [ 0 => "Leprosy" 1 => "Leprosy, multibacillary" 2 => "Panniculitis" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Leprosy is an infectious disease with chronic evolution, caused by <span class="elsevierStyleItalic">Mycobacterium leprae</span>, an acid-fast bacillus that mainly affects the skin and peripheral nervous tissue. Many of the clinical manifestations of leprosy can mimic connective tissue diseases. The authors present the case of a 49-year-old woman who had been treated for four years for systemic lupus erythematosus in a rheumatological service. Skin biopsy of a plaque on the inguinal region was compatible with borderline lepromatous leprosy associated with a type 1 lepra reaction. The patient is undergoing treatment with multibacillary multidrug therapy, showing clinical improvement.</p></span>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Góes LDM, Scrignoli JA, Morais P, Talhari C. Case for diagnosis. Infiltrated areas on the trunk. An Bras Dermatol. 2020. <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.abd.2019.12.007">https://doi.org/10.1016/j.abd.2019.12.007</span></p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brasil.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 681 "Ancho" => 905 "Tamanyo" => 103991 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous plaques on the trunk.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 680 "Ancho" => 905 "Tamanyo" => 133536 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Erythematous plaques on the back of the hand and infiltration of the fingers.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 460 "Ancho" => 1255 "Tamanyo" => 136947 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A), Perivascular and periadnexal inflammatory infiltrate composed of lymphocytes, histiocytes, plasma cells, and epithelioid cells (Hematoxylin & eosin, ×40); (B), Fragmented, granular, isolated acid-fast bacilli, also grouped in globi (Wade, ×40).</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 606 "Ancho" => 905 "Tamanyo" => 58294 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Residual hyperchromic patches on the trunk and upper limbs after 30 days of treatment with multidrug therapy and prednisone.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hanseníase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Talhari" 1 => "G.O. Penna" 2 => "H.S. Gonçalves" 3 => "M.L.W. Oliveira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "5th ed." "fecha" => "2014" "editorial" => "Editora DiLivros" "editorialLocalizacion" => "Manaus" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.C.D.S. Cruz" 1 => "S. Bührer-Sékula" 2 => "M.L.F. Penna" 3 => "G.O. Penna" 4 => "S. Talhari" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2017" "volumen" => "92" "paginaInicial" => "761" "paginaFinal" => "773" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The rheumatic manifestations of leprosy (Hansen disease)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.A. Albert" 1 => "M.H. Weisman" 2 => "R. Kaplan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "1980" "volumen" => "59" "paginaInicial" => "442" "paginaFinal" => "448" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leprosy-related joint involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.L. Pereira" 1 => "S.L. Ribeiro" 2 => "S.N. Pennini" 3 => "E.I. Sato" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2009" "volumen" => "28" "paginaInicial" => "79" "paginaFinal" => "84" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased incidence of cytoplasmic ANCA (cANCA) and other autoantibodies in leprosy patients from western India" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V. Pradhan" 1 => "S.S. Badakere" 2 => "U. Shankar Kumar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lepr Rev" "fecha" => "2004" "volumen" => "75" "paginaInicial" => "50" "paginaFinal" => "56" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-cyclic citrullinated peptide antibodies and rheumatoid factor sera titers in leprosy patients from Mexico" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.G. Zavala-Cerna" 1 => "M. Fafutis-Morris" 2 => "C. Guillen-Vargas" 3 => "M. Salazar-Páramo" 4 => "D.E. García-Cruz" 5 => "C. Riebeling" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00296-011-2224-0" "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2012" "volumen" => "32" "paginaInicial" => "3531" "paginaFinal" => "3536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22083616" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiphospholipid antibodies in leprotic patients: a correlation with disease manifestations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Elbeialy" 1 => "K. Strassburger-Lorna" 2 => "T. Atsumi" 3 => "M.L. Bertolaccini" 4 => "O. Amengual" 5 => "M. Hanafi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "492" "paginaFinal" => "494" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multibacillary leprosy mimicking systemic lupus erythematosus: case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Horta-Baas" 1 => "M.F. Hernández-Cabrera" 2 => "L.A. Barile-Fabris" 3 => "M.S. Romero-Figueroa del" 4 => "R. Arenas-Guzmán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lupus" "fecha" => "2015" "volumen" => "24" "paginaInicial" => "1095" "paginaFinal" => "1102" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse alopecia of the scalp in borderline lepromatosus leprosy in an Indian patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Abraham" 1 => "G.J. Ebenezer" 2 => "K. Jesudasan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5935/0305-7518.19970043" "Revista" => array:6 [ "tituloSerie" => "Lepr Rev" "fecha" => "1997" "volumen" => "68" "paginaInicial" => "336" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9503871" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Application of the diagnostic criteria for systemic lupus erythematosus to patients with multibacillary leprosy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Teixeira" 1 => "C. Silva" 2 => "V. Magalhães" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Soc Bras Med Trop" "fecha" => "2011" "volumen" => "44" "paginaInicial" => "85" "paginaFinal" => "90" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301690/v2_202011080908/en/main.assets" "Apartado" => array:4 [ "identificador" => "80633" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "What is your Diagnosis?" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000005/v2_202011080908/S0365059620301690/v2_202011080908/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301690?idApp=UINPBA00008Z" ]
| Ano/Mês | Html | Total | |
|---|---|---|---|
| 2024 Novembro | 11 | 7 | 18 |
| 2024 Outubro | 91 | 77 | 168 |
| 2024 Setembro | 102 | 80 | 182 |
| 2024 Agosto | 135 | 94 | 229 |
| 2024 Julho | 119 | 117 | 236 |
| 2024 Junho | 94 | 72 | 166 |
| 2024 Maio | 73 | 69 | 142 |
| 2024 Abril | 78 | 82 | 160 |
| 2024 Março | 74 | 78 | 152 |
| 2024 Fevereiro | 78 | 75 | 153 |
| 2024 Janeiro | 56 | 66 | 122 |
| 2023 Dezembro | 57 | 79 | 136 |
| 2023 Novembro | 73 | 78 | 151 |
| 2023 Outubro | 56 | 71 | 127 |
| 2023 Setembro | 73 | 80 | 153 |
| 2023 Agosto | 61 | 43 | 104 |
| 2023 Julho | 52 | 34 | 86 |
| 2023 Junho | 57 | 42 | 99 |
| 2023 Maio | 37 | 21 | 58 |
| 2023 Abril | 21 | 19 | 40 |
| 2023 Março | 41 | 38 | 79 |
| 2023 Fevereiro | 33 | 31 | 64 |
| 2023 Janeiro | 24 | 29 | 53 |
| 2022 Dezembro | 39 | 24 | 63 |
| 2022 Novembro | 50 | 52 | 102 |
| 2022 Outubro | 54 | 45 | 99 |
| 2022 Setembro | 39 | 58 | 97 |
| 2022 Agosto | 32 | 39 | 71 |
| 2022 Julho | 29 | 45 | 74 |
| 2022 Junho | 32 | 57 | 89 |
| 2022 Maio | 32 | 49 | 81 |
| 2022 Abril | 30 | 39 | 69 |
| 2022 Março | 33 | 63 | 96 |
| 2022 Fevereiro | 31 | 42 | 73 |
| 2022 Janeiro | 40 | 84 | 124 |
| 2021 Dezembro | 32 | 56 | 88 |
| 2021 Novembro | 30 | 62 | 92 |
| 2021 Outubro | 47 | 73 | 120 |
| 2021 Setembro | 24 | 42 | 66 |
| 2021 Agosto | 35 | 54 | 89 |
| 2021 Julho | 32 | 45 | 77 |
| 2021 Junho | 27 | 52 | 79 |
| 2021 Maio | 47 | 94 | 141 |
| 2021 Abril | 116 | 215 | 331 |
| 2021 Março | 56 | 70 | 126 |
| 2021 Fevereiro | 28 | 25 | 53 |
| 2021 Janeiro | 30 | 21 | 51 |
| 2020 Dezembro | 16 | 18 | 34 |
| 2020 Novembro | 41 | 13 | 54 |
| 2020 Outubro | 21 | 7 | 28 |
| 2020 Setembro | 13 | 10 | 23 |
| 2020 Agosto | 10 | 8 | 18 |
| 2020 Julho | 26 | 10 | 36 |
| 2020 Junho | 3 | 5 | 8 |
Mostrar tudo
