que se leu este artigo
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One was in the splice site, c.1391-2A>C from her father, and also was seen in her sister. The other was a deletion mutation, c.2492_2493delAT (p.His831Argfs) from her mother.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xinyue Zhang, Songmei Geng, Yi Zheng" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Xinyue" "apellidos" => "Zhang" ] 1 => array:2 [ "nombre" => "Songmei" "apellidos" => "Geng" ] 2 => array:2 [ "nombre" => "Yi" "apellidos" => "Zheng" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220302083" "doi" => "10.1016/j.abdp.2020.05.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302083?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301252?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301252/v3_202008041755/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059620301306" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.12.005" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "202" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Research Letter</span>" "titulo" => "Cutaneous metastases from primary solid and hematopoietic neoplasms at a referral hospital in Colombia: a cross-sectional study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "533" "paginaFinal" => "535" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Fernanda Ordóñez-Rubiano, Victoria Lucía Dávila-Osorio, Paula Celeste Rubiano-Mojica, Ángela Marcela Mariño-Álvarez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "María Fernanda" "apellidos" => "Ordóñez-Rubiano" ] 1 => array:2 [ "nombre" => "Victoria Lucía" "apellidos" => "Dávila-Osorio" ] 2 => array:2 [ "nombre" => "Paula Celeste" "apellidos" => "Rubiano-Mojica" ] 3 => array:2 [ "nombre" => "Ángela Marcela" "apellidos" => "Mariño-Álvarez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220302058" "doi" => "10.1016/j.abdp.2019.12.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302058?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301306?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301306/v3_202008041755/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Sporadic form of epidermolysis bullosa simplex with mottled pigmentation" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "536" "paginaFinal" => "538" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Flávia Regina Ferreira, Carolina Fernandes Pereira, Juliana Carvalho Moretto, Mariana Patriota Naville" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Flávia Regina" "apellidos" => "Ferreira" "email" => array:1 [ 0 => "dermagica@uol.com.br" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Carolina Fernandes" "apellidos" => "Pereira" ] 2 => array:2 [ "nombre" => "Juliana Carvalho" "apellidos" => "Moretto" ] 3 => array:2 [ "nombre" => "Mariana Patriota" "apellidos" => "Naville" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Dermatology Service, Hospital Universitário de Taubaté, Taubaté, SP, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 642 "Ancho" => 1007 "Tamanyo" => 52235 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Close-up. Desiccated blisters and vesicles on the left foot.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Epidermolysis bullosa (EB) composes a group of hereditary bullous disorders in which the blisters arise spontaneously or are triggered by minimal trauma. Koebner suggested this denomination in 1886. EB is divided into four major types (simplex, junctional, dystrophic, and Kindler syndrome) and several distinct clinical phenotypes, according to the level of skin cleavage, as well as clinical and molecular characteristics.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP) is an uncommon subtype of epidermolysis bullosa simplex (EBS; Online Mendelian Inheritance in Man [OMIM] No. 131960). It is characterized by non-cicatricial blisters, mainly at the distal extremities, and progressive mottled hyperpigmentation. Until 2013, only 15 families and eight sporadic cases had been reported, according to the data from the Hospital Infantil Universitário Niño Jesus, in Madrid, which motivated this report.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 2-year-old girl, phototype III, with a history of blistering skin since birth. On dermatological examination she had desiccated blisters on the feet, as well as hyper- and hypochromic macules scattered over the tegument with mottled appearance (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>). Normochromic papules on the dorsal region of the fingers and onychodystrophy were also seen. The blisters appeared spontaneously or after minimal trauma, according to the mother's report, and were located mainly at the distal extremities of the limbs. At two months of age, the hyper- and hypochromic macules began. The mother also referred episodes of oral mucositis. Immunomapping result (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) coupled with the patient's clinical and laboratory findings confirmed the diagnosis of EBS-MP. This is probably a sporadic case since family history fo EB or other bullous disese is negative. The patient is under outpatient clinic follow-up. Family orientations were conducted in order to reduce the occurrence of new blisters and improve the coexistence of the patient with her genodermatosis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">First described in 1979 by Fischer and Gedd-Dahl, EBS-MP begins in childhood and has a genetic origin. It is a basal EBS caused by a mutation in the KRT5 gene that encodes cytokeratin 5. It occurs most commonly due to a punctual heterozygous p24L mutation in the non-helical V1 domain of cytokeratin 5.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of this dermatosis is based on typical clinical findings, family history, immunomapping, and/or transmission electron microscopy, as well as molecular/mutation analysis when possible.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically, it is characterized by non-cicatricial blisters, mainly at the distal extremities, as well as progressive mottled hyperpigmentation, which does not occur at the site of the blisters and often disappears in adulthood. Some cases may be accompanied by hypopigmented macules, as could be seen in this patient. There are also reports of palmar and plantar focal hyperkeratosis. Small acral verrucous papules, onychodystrophy, and mild involvement of the oral mucosa can be observed during childhood. Uncommon findings include photosensitivity and dental disorders (caries).<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The differential diagnosis of EBS-MP includes other types of EBS (mainly the herpetiformis type of Dowling-Meara), Kindler syndrome, Naegeli-Franceschetti-Jadassohn (NFJ) ectodermal dysplasia, other forms of dyschromia, Dowling-Degos disease, and even atypical cases of Darier's disease with mutations in ATP2A2.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Due to the clinical hypothesis of EB and to determine the level of skin cleavage, immunomapping or transmission electron microscopy should be performed. The immunomapping has diagnostic accuracy similar to transmission electron microscopy, with the advantage of simple and fast execution and reading. It is associated with the use of monoclonal antibodies and may be considered an indirect immunofluorescence technique. In the EBS, the skin cleavage occurs in the basal layer (intra-epidermal), and fluorescence deposition on the blister floor (dermal side) is seen with all antigenic markers (bullous pemphigoid antigen, laminin, collagens IV and VII), as observed in this case.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Ultrastructural analysis of the pigmented areas in this form of EBS demonstrates abundant mature melanosomes within the basal cells.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Thus, this report details a rare case of a possibly sporadic EBS-MP. The authors emphasize the rarity of this subtype of EBS and its remarkable clinical characteristics favoring future diagnoses, and highlight its benign character, with no scarring or deforming lesions and regression of hyperpigmentation in adulthood.</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors’ contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">Flávia Regina Ferreira: Approval of final version of the manuscript; conception and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Carolina Fernandes Pereira: Approval of final version of the manuscript; conception and planning of the study; drafting and editing of the manuscript; critical review of the literature.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Juliana Carvalho Moretto: Approval of final version of the manuscript; conception and planning of the study; drafting and editing of the manuscript; critical review of the literature.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Mariana Patriota Naville: Approval of final version of the manuscript; conception and planning of the study; drafting and editing of the manuscript; critical review of the literature.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0005" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-05-01" "fechaAceptado" => "2019-08-20" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Ferreira FR, Pereira CF, Moretto JC, Naville MP. Sporadic form of epidermolysis bullosa simplex with mottled pigmentation. An Bras Dermatol. 2020;95:536–8.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Hospital Universitário de Taubaté, Taubaté, SP, Brazil.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2678 "Ancho" => 1007 "Tamanyo" => 175262 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Disseminated hyper- and hypochromic macules scattered over the tegument with mottled appearance.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 642 "Ancho" => 1007 "Tamanyo" => 52235 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Close-up. Desiccated blisters and vesicles on the left foot.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 924 "Ancho" => 1074 "Tamanyo" => 127785 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Immunomapping: fluorescence deposition on the blister floor (dermal side) observed with all antigenic markers (bullous pemphigoid antigen, laminin, collagens IV and VII).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. 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Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 21 | 14 | 35 |
2024 Outubro | 101 | 70 | 171 |
2024 Setembro | 169 | 86 | 255 |
2024 Agosto | 152 | 105 | 257 |
2024 Julho | 129 | 119 | 248 |
2024 Junho | 151 | 107 | 258 |
2024 Maio | 105 | 77 | 182 |
2024 Abril | 106 | 85 | 191 |
2024 Março | 81 | 74 | 155 |
2024 Fevereiro | 74 | 83 | 157 |
2024 Janeiro | 46 | 60 | 106 |
2023 Dezembro | 65 | 65 | 130 |
2023 Novembro | 64 | 80 | 144 |
2023 Outubro | 68 | 73 | 141 |
2023 Setembro | 114 | 68 | 182 |
2023 Agosto | 79 | 42 | 121 |
2023 Julho | 49 | 38 | 87 |
2023 Junho | 51 | 50 | 101 |
2023 Maio | 44 | 18 | 62 |
2023 Abril | 37 | 15 | 52 |
2023 Março | 59 | 53 | 112 |
2023 Fevereiro | 46 | 33 | 79 |
2023 Janeiro | 40 | 35 | 75 |
2022 Dezembro | 51 | 27 | 78 |
2022 Novembro | 60 | 50 | 110 |
2022 Outubro | 81 | 54 | 135 |
2022 Setembro | 52 | 63 | 115 |
2022 Agosto | 41 | 47 | 88 |
2022 Julho | 34 | 57 | 91 |
2022 Junho | 50 | 46 | 96 |
2022 Maio | 32 | 68 | 100 |
2022 Abril | 36 | 40 | 76 |
2022 Março | 40 | 75 | 115 |
2022 Fevereiro | 18 | 35 | 53 |
2022 Janeiro | 61 | 91 | 152 |
2021 Dezembro | 37 | 76 | 113 |
2021 Novembro | 43 | 56 | 99 |
2021 Outubro | 54 | 76 | 130 |
2021 Setembro | 37 | 52 | 89 |
2021 Agosto | 36 | 44 | 80 |
2021 Julho | 39 | 46 | 85 |
2021 Junho | 29 | 63 | 92 |
2021 Maio | 42 | 71 | 113 |
2021 Abril | 93 | 256 | 349 |
2021 Março | 36 | 49 | 85 |
2021 Fevereiro | 17 | 21 | 38 |
2021 Janeiro | 21 | 20 | 41 |
2020 Dezembro | 22 | 20 | 42 |
2020 Novembro | 24 | 13 | 37 |
2020 Outubro | 17 | 17 | 34 |
2020 Setembro | 23 | 18 | 41 |
2020 Agosto | 10 | 11 | 21 |
2020 Julho | 30 | 12 | 42 |
2020 Junho | 14 | 10 | 24 |
2020 Maio | 3 | 5 | 8 |