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3</a>&#41;&#46; We diagnosed this patient as having clear cell acanthoma &#40;CCA&#41;&#44; without recurrence for 4 months after excision&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">CCA&#44; or Degos acanthoma&#44; is a rare clinical entity first described by Degos in 1962&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The etiology of CCA is still not clearly known&#46; It is traditionally considered to be a form of benign epidermal neoplasia&#46; Meanwhile&#44; there are speculations that CCA may be an inflammatory reactive dermatosis or localized psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> CCA generally arises on the lower extremities and is characterized by an asymptomatic&#44; red-brown&#44; dome-shaped&#44; solitary papule or nodule often covered by a thin collarette of scale&#46; Additionally&#44; giant&#44; pedunculated&#44; multiple&#44; cystic and pigmented patterns may be seen in CCA&#46; The histopathological features include a well-demarcated area of psoriasiform acanthosis with keratinocytes with pale staining cytoplasm&#44; intercellular edema&#44; parakeratotic microabscesses and edematous papillary dermis as well as the superficial capillaries and veins increased&#46; CCA must be differentiated from actinic or seborrhoeic keratoses&#44; basal cell carcinoma&#44; squamous cell carcinoma&#44; pyogenic granulomas&#44; clear cell hidradenoma and amelanotic melanoma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Under dermoscopy&#44; CCA has a unique appearance that is helpful to improve diagnostic accuracy&#44; characterized by red dots&#44; globules&#44; and glomerular vessels arranged in linear or serpiginous patterns as well as a collarette of scale surrounding&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The dermoscopic feature of &#8220;string of pearls&#8221; corresponds to the histopathology of CCA on transverse sections that indicates uniformly sized dermal islands with a string-like distribution and abundant dilated capillaries&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> However&#44; Espinosa recently reported that the dermoscopic feature of &#8220;string of pearls&#8221; pattern was also found in seborrheic keratosis and lichen-planus-like keratosis and suggested that other epidermal tumors&#44; especially having the similar pathological pattern&#44; could also show this dermoscopic pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Hence&#44; Biopsy is still not avoided in the diagnosis of CCA&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contributions</span><p id="par0020" class="elsevierStylePara elsevierViewall">Li-wen Zhang&#58; Conception and planning of the study&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the literature&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Wen-Ju Wang&#58; Concep&#231;&#227;o e planejamento do estudo&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Cong-Hui Li&#58; Critical review of the literature&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Tao Chen&#58; Critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
The string of pearls pattern in dermoscopy of a chest papule
Li-Wen Zhang1,
Autor para correspondência
zhleven@126.com

Corresponding author.
, Wen-Ju Wang1, Cong-Hui Li, Tao Chen
Department of Dermatovenereology, Chengdu Second People's Hospital, Chengdu, Sichuan, China
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 49-year-old woman presented with a 3-year history of an asymptomatic red dome-shaped papule on her left chest&#46; The lesion slowly enlarged &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There was no relevant medical history and family history&#46; Dermoscopy showed glomerular and dotted vessels with &#8220;string of pearls&#8221; pattern distribution&#44; and a collarette of scale surrounding &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Excisional biopsy of the lesion with histopathological examination showed a sharply demarcated psoriasiform epidermal hyperplasia composed of slightly enlarged clear keratinocytes and basal cells with pale-staining cytoplasm&#44; dilated blood vessels in the dermal papillae as well as perivascular mixed inflammatory infiltration &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; We diagnosed this patient as having clear cell acanthoma &#40;CCA&#41;&#44; without recurrence for 4 months after excision&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">CCA&#44; or Degos acanthoma&#44; is a rare clinical entity first described by Degos in 1962&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The etiology of CCA is still not clearly known&#46; It is traditionally considered to be a form of benign epidermal neoplasia&#46; Meanwhile&#44; there are speculations that CCA may be an inflammatory reactive dermatosis or localized psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> CCA generally arises on the lower extremities and is characterized by an asymptomatic&#44; red-brown&#44; dome-shaped&#44; solitary papule or nodule often covered by a thin collarette of scale&#46; Additionally&#44; giant&#44; pedunculated&#44; multiple&#44; cystic and pigmented patterns may be seen in CCA&#46; The histopathological features include a well-demarcated area of psoriasiform acanthosis with keratinocytes with pale staining cytoplasm&#44; intercellular edema&#44; parakeratotic microabscesses and edematous papillary dermis as well as the superficial capillaries and veins increased&#46; CCA must be differentiated from actinic or seborrhoeic keratoses&#44; basal cell carcinoma&#44; squamous cell carcinoma&#44; pyogenic granulomas&#44; clear cell hidradenoma and amelanotic melanoma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Under dermoscopy&#44; CCA has a unique appearance that is helpful to improve diagnostic accuracy&#44; characterized by red dots&#44; globules&#44; and glomerular vessels arranged in linear or serpiginous patterns as well as a collarette of scale surrounding&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The dermoscopic feature of &#8220;string of pearls&#8221; corresponds to the histopathology of CCA on transverse sections that indicates uniformly sized dermal islands with a string-like distribution and abundant dilated capillaries&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> However&#44; Espinosa recently reported that the dermoscopic feature of &#8220;string of pearls&#8221; pattern was also found in seborrheic keratosis and lichen-planus-like keratosis and suggested that other epidermal tumors&#44; especially having the similar pathological pattern&#44; could also show this dermoscopic pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Hence&#44; Biopsy is still not avoided in the diagnosis of CCA&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contributions</span><p id="par0020" class="elsevierStylePara elsevierViewall">Li-wen Zhang&#58; Conception and planning of the study&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the literature&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Wen-Ju Wang&#58; Concep&#231;&#227;o e planejamento do estudo&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Cong-Hui Li&#58; Critical review of the literature&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Tao Chen&#58; Critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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