que se leu este artigo
array:24 [ "pii" => "S0365059619301710" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.02.010" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "117" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2019" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 11 "formatos" => array:2 [ "EPUB" => 4 "PDF" => 7 ] ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275220300126" "issn" => "26662752" "doi" => "10.1016/j.abdp.2019.02.010" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "117" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta ‐ Caso clínico</span>" "titulo" => "Xantogranuloma múltiplo do adulto" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "113" "paginaFinal" => "115" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 610 "Ancho" => 750 "Tamanyo" => 160232 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Proliferação histiocitária difusa na derme superficial e profunda associada com infiltrado linfocitário e com células gigantes multinucleadas de Touton (Hematoxilina & eosina, 100×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Renata da Costa Almeida, Óscar Tellechea, Mariana Pinho Pereira, Rosa Cristina Correia Mascarenhas" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Renata da Costa" "apellidos" => "Almeida" ] 1 => array:2 [ "nombre" => "Óscar" "apellidos" => "Tellechea" ] 2 => array:2 [ "nombre" => "Mariana Pinho" "apellidos" => "Pereira" ] 3 => array:2 [ "nombre" => "Rosa Cristina Correia" "apellidos" => "Mascarenhas" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059619301710" "doi" => "10.1016/j.abd.2019.02.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059619301710?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220300126?idApp=UINPBA00008Z" "url" => "/26662752/0000009500000001/v1_202003280637/S2666275220300126/v1_202003280637/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059619301680" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.03.006" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "114" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 14 "formatos" => array:2 [ "EPUB" => 3 "PDF" => 11 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Treatment of Kimura's disease with oral corticosteroid and methotrexate" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "115" "paginaFinal" => "117" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 518 "Ancho" => 758 "Tamanyo" => 104194 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nodular lymphocytic infiltrate with germinal centers involving the dermis and subcutaneous tissue, and reactive germinal centers surrounded by small mature lymphocytes and eosinophils (arrow) (Hematoxylin & eosin, ×100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Han Ma" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Han" "apellidos" => "Ma" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220300096" "doi" => "10.1016/j.abdp.2019.03.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220300096?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059619301680?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000001/v3_202003240622/S0365059619301680/v3_202003240622/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0365059619301722" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.02.011" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "118" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 16 "formatos" => array:2 [ "EPUB" => 8 "PDF" => 8 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Papillary syringocystadenoma in an uncommon location" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "112" "paginaFinal" => "113" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 453 "Ancho" => 750 "Tamanyo" => 33031 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rose-colored papule on the left flank.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Giovanna de Araujo Horcel, Juliana Milhomem, Samuel Henrique Mandelbaum, Rodrigo Ieiri" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Giovanna de Araujo" "apellidos" => "Horcel" ] 1 => array:2 [ "nombre" => "Juliana" "apellidos" => "Milhomem" ] 2 => array:2 [ "nombre" => "Samuel Henrique" "apellidos" => "Mandelbaum" ] 3 => array:2 [ "nombre" => "Rodrigo" "apellidos" => "Ieiri" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220300138" "doi" => "10.1016/j.abdp.2019.02.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220300138?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059619301722?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000001/v3_202003240622/S0365059619301722/v3_202003240622/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Multiple adult xanthogranuloma" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "113" "paginaFinal" => "115" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Renata da Costa Almeida, Óscar Tellechea, Mariana Pinho Pereira, Rosa Cristina Correia Mascarenhas" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Renata da Costa" "apellidos" => "Almeida" "email" => array:1 [ 0 => "renatadacostaalmeida@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Óscar" "apellidos" => "Tellechea" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Mariana Pinho" "apellidos" => "Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 3 => array:3 [ "nombre" => "Rosa Cristina Correia" "apellidos" => "Mascarenhas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Physician Assistant in Family Medicine, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Dermatology Service, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Dermatology Service, Hospital Distrital da Figueira da Foz, Figueira da Foz, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Physician Assistant in Family Medicine, Unidade de Cuidados de Saúde Primários Litoral, Alfeizerão, Portugal" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 567 "Ancho" => 756 "Tamanyo" => 115393 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Infiltration circumscribed of the dermis by xanthomized histiocytes and multinucleated Touton giant cells (Hematoxylin & eosin, ×400).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Xanthogranuloma (XG) is a normolipemic non-Langerhans cell histiocytosis (NLCH) most commonly seen in childhood and generally designed as juvenile xanthogranuloma (JXG). Infrequently, XG can occur in adulthood. Both in adults and children, XG usually presents as a solitary lesion. Multiple lesions are rare in JXG and exceptional in adults. The authors report a case of multiple adult xanthogranuloma (MAXG) of the face, neck, trunk, abdomen, and axillae, with no extracutaneous involvement and no association with hematologic disease.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 38-year-old female, with no relevant personal or family history of the disease, was seen in October 2016 with multiple papules on her skin, which she first noticed 18 months before. Dermatologic examination showed more than 100 yellowish-brown, smooth, firm papules with diameters of 1–3<span class="elsevierStyleHsp" style=""></span>mm on the face, neck, thorax, abdomen, and axillae (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), two larger elements, standing out in the outer corner of the right eye and in the homolateral nasogenian groove. The lesions were asymptomatic and the general physical examination (including ophthalmologic, cardiopulmonary, and neurologic) was normal.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The diagnostic hypotheses of syringomas, sarcoidosis, xanthomas, and histiocytosis were considered, and two lesions were excised for histopathologic evaluation. This disclosed, in both specimens, a circumscribed dense dermal cellular infiltrate composed of large histiocytes, mostly exhibiting xanthomized cytoplasm, accompanied by multinucleated giant cells, including some of the Touton type. Interspersed inflammatory cells were also present, mostly small lymphocytes with occasional neutrophils and some eosinophils (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>). Immunohistochemical evaluation documented absence of S100 protein, and CD1a immunoreactivity and diffuse CD68 positivity, supporting the diagnosis of XG.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">General laboratorial and imaging evaluation (including β2 microglobulin, serum protein electrophoresis, skeletal and thorax X-ray, and abdominopelvic echography) showed no abnormalities. On the basis of the clinico-laboratorial and imaging findings, the diagnosis of MAXG was obtained. Ablation of the larger and cosmetically more-disturbing lesions by CO<span class="elsevierStyleInf">2</span> laser or electrosurgery was performed, with good results. During the follow-up period of almost two years, the untreated cutaneous lesions persisted, with no development of extracutaneous lesions nor hematologic alterations.</p><p id="par0025" class="elsevierStylePara elsevierViewall">XG is the most common type of NLCH.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The presentation of XG in adulthood is infrequent, occurring generally in the 3rd or 4th decades of life, without gender predominance.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> As in JXG, most cases of adult XG manifest as a solitary papule or nodule on the face.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The occurrence of multiple XG lesions in adults is rare. MAXG is defined by more than five XGs in patients over 14 years of age.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> According to these criteria, 118 cases of MAXG have been reported from 1969 to 2004.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The etiopathogenesis of MAXG is unknown.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">JXG and MAXG exhibit identical histologic and immunohistochemical findings.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Mature lesions show, as in the present case, a circumscribed nodular dermal proliferation composed of xanthomized histiocytes, characteristically accompanied by Touton multinucleated cells.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1,4</span></a> The histiocytic nature of the proliferation is confirmed by their CD68 positivity and absence of S100 protein, as well as CD1a immunoreactivity, with variable expression of factor XIIIa.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4,5</span></a> Nevertheless, these microscopic and immunochemical findings are not pathognomonic for XG and, in the present patient, other forms of adult NLCH presenting with multiple lesions needed to be excluded, namely Erdheim–Chester disease (ECD), as well as eruptive disseminated histiocytoma (EDG), and more remotely, disseminated xanthoma (DX) and multicentric reticulohistiocytosis (RM).<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The absence of skeletal abnormalities allowed to exclude ECD. In EDG, the lesions do not contain Touton cells. These can, however, occur in DX, but in the present patient no linear periflexural lesions, which characterize DX, were present. In RM cutaneous lesions are acrally located, accompanied by arthropathy and microscopically characterized by large multinucleated ground-glass cells, aspects absent in the present case.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Clinically, MAXG presents as yellow-orange or brownish papules and/or nodules distributed on the trunk, face, neck, and less frequently, the limbs. More than 10 lesions are present in only about 6% of the reported cases.</p><p id="par0045" class="elsevierStylePara elsevierViewall">In contrast with JXG, in which ocular and, less frequently, other organ involvement may occur, MAXG does not seem to evolve with extracutaneous histiocytic infiltration. Accordingly, exhaustive systemic investigation is not recommended in every patient. Nevertheless, as in JXG, MAXG can be a marker of malignant blood disease, a possibility that should be considered whenever B symptoms and/or alterations of the electrophoretic proteinogram occur.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3–5</span></a> These, as well as full blood tests, were systematically absent/negative in the present patient during the almost two years of follow-up.</p><p id="par0050" class="elsevierStylePara elsevierViewall">As spontaneous regression of the lesions in MAXG is less probable than in JXG, surgical excision, electrosurgery, ablation by CO<span class="elsevierStyleInf">2</span> laser, or systemic retinoids – namely isotretinoin – have been recommended as treatments whenever lesions are numerous, cause discomfort, or are unesthetic. In the present patient, a female of child-bearing age, the larger papules were treated iteratively with CO<span class="elsevierStyleInf">2</span> laser or electrosurgery, with a good cosmetic result.</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion, MAXG is a rare type of adult normolipemic NLCH, whose significance is insufficiently known, and is occasionally associated with hematologic malignancy that occur simultaneously, preceded by or following the diagnosis of this histiocytosis,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> thereby requiring a focused and long-term follow-up of the patients.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contribution</span><p id="par0065" class="elsevierStylePara elsevierViewall">Renata da Costa Almeida: Approval of the final version of the manuscript; composition of the manuscript; design of the study; critical review of the literature; critical review of the manuscript.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Óscar Tellechea: Approval of the final version of the manuscript; composition of the manuscript; design of the study; critical review of the literature; critical review of the manuscript.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Mariana Pinho Pereira: Approval of the final version of the manuscript; composition of the manuscript; design of the study; critical review of the literature; critical review of the manuscript.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Rosa Cristina Correia Mascarenhas: Approval of the final version of the manuscript; composition of the manuscript; collection, analysis, and interpretation of data; design of the study; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contribution" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:2 [ "identificador" => "xack455503" "titulo" => "Acknowledgment" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-01-11" "fechaAceptado" => "2019-02-12" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Almeida RC, Tellechea O, Pereira MP, Mascarenhas RCC. Multiple adult xanthogranuloma. An Bras Dermatol. 2020;95:113–5.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Hospital Distrital da Figueira da Foz, Figueira da Foz, Portugal.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 602 "Ancho" => 756 "Tamanyo" => 36455 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple xanthogranulomas. Detail of yellowish-brown, smooth, firm papules with diameters of 1–3<span class="elsevierStyleHsp" style=""></span>mm, asymptomatic, located on the face.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 567 "Ancho" => 756 "Tamanyo" => 115393 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Infiltration circumscribed of the dermis by xanthomized histiocytes and multinucleated Touton giant cells (Hematoxylin & eosin, ×400).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 617 "Ancho" => 757 "Tamanyo" => 105934 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Diffuse histiocytic proliferation in the superficial and deep dermis associated with lymphocytic infiltrate and with multinucleated Touton giant cells (Hematoxylin & eosin, ×100).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple adult xanthogranuloma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Navajas" 1 => "P. Eguino" 2 => "I. Trébol" 3 => "O. Lasa" 4 => "J. Gardeazábal" 5 => "J.L. Díaz-Pérez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000089027" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2006" "volumen" => "212" "paginaInicial" => "73" "paginaFinal" => "76" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16319479" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple generalized xanthogranuloma in adult: case report and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Achar" 1 => "B. Naskar" 2 => "P.C. Mondal" 3 => "M. Pal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0019-5154.80416" "Revista" => array:6 [ "tituloSerie" => "Indian J Dermatol" "fecha" => "2011" "volumen" => "56" "paginaInicial" => "197" "paginaFinal" => "199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21716547" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concurrent development of eruptive xanthogranulomas and hematologic malignancy: two case reports" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. Larson" 1 => "C. Bandel" 2 => "P.J. Eichhorn" 3 => "P.D. Cruz Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2003.08.019" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2004" "volumen" => "50" "paginaInicial" => "976" "paginaFinal" => "978" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15153909" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous infiltrates – non lymphoid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Patterson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "B.Ronald, M.D.Johnston" "titulo" => "Weedon's skin pathology" "paginaInicial" => "951" "paginaFinal" => "960" "serieFecha" => "2009" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histiocytoses and malignant skin diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Paller" 1 => "A.J. Mancini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "S.Amy, A.Paller, J.Anthony" "titulo" => "Hurwitz clinical pediatric dermatology: a textbook of skin disorders of childhood and adolescence" "paginaInicial" => "219" "paginaFinal" => "226" "serieFecha" => "2011" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack455503" "titulo" => "Acknowledgment" "texto" => "<p id="par0090" class="elsevierStylePara elsevierViewall">To my academic adviser, Doctor Ana Sofia Bento, for stimulating and assisting me in the writing of this article.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009500000001/v3_202003240622/S0365059619301710/v3_202003240622/en/main.assets" "Apartado" => array:4 [ "identificador" => "82769" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Letter" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000001/v3_202003240622/S0365059619301710/v3_202003240622/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059619301710?idApp=UINPBA00008Z" ]
Ano/Mês | Html | Total | |
---|---|---|---|
2024 Novembro | 37 | 15 | 52 |
2024 Outubro | 169 | 74 | 243 |
2024 Setembro | 237 | 89 | 326 |
2024 Agosto | 200 | 100 | 300 |
2024 Julho | 226 | 135 | 361 |
2024 Junho | 163 | 99 | 262 |
2024 Maio | 159 | 64 | 223 |
2024 Abril | 115 | 85 | 200 |
2024 Março | 115 | 71 | 186 |
2024 Fevereiro | 129 | 67 | 196 |
2024 Janeiro | 110 | 44 | 154 |
2023 Dezembro | 63 | 58 | 121 |
2023 Novembro | 82 | 69 | 151 |
2023 Outubro | 73 | 88 | 161 |
2023 Setembro | 70 | 67 | 137 |
2023 Agosto | 61 | 31 | 92 |
2023 Julho | 61 | 28 | 89 |
2023 Junho | 79 | 29 | 108 |
2023 Maio | 71 | 20 | 91 |
2023 Abril | 47 | 15 | 62 |
2023 Março | 66 | 47 | 113 |
2023 Fevereiro | 46 | 32 | 78 |
2023 Janeiro | 42 | 44 | 86 |
2022 Dezembro | 57 | 34 | 91 |
2022 Novembro | 70 | 49 | 119 |
2022 Outubro | 61 | 64 | 125 |
2022 Setembro | 62 | 65 | 127 |
2022 Agosto | 46 | 41 | 87 |
2022 Julho | 45 | 53 | 98 |
2022 Junho | 39 | 53 | 92 |
2022 Maio | 31 | 40 | 71 |
2022 Abril | 39 | 44 | 83 |
2022 Março | 37 | 72 | 109 |
2022 Fevereiro | 36 | 22 | 58 |
2022 Janeiro | 58 | 66 | 124 |
2021 Dezembro | 36 | 47 | 83 |
2021 Novembro | 46 | 54 | 100 |
2021 Outubro | 51 | 67 | 118 |
2021 Setembro | 33 | 40 | 73 |
2021 Agosto | 39 | 44 | 83 |
2021 Julho | 44 | 44 | 88 |
2021 Junho | 40 | 39 | 79 |
2021 Maio | 33 | 59 | 92 |
2021 Abril | 103 | 166 | 269 |
2021 Março | 55 | 47 | 102 |
2021 Fevereiro | 13 | 19 | 32 |
2021 Janeiro | 29 | 18 | 47 |
2020 Dezembro | 35 | 14 | 49 |
2020 Novembro | 42 | 16 | 58 |
2020 Outubro | 20 | 10 | 30 |
2020 Setembro | 17 | 10 | 27 |
2020 Agosto | 19 | 9 | 28 |
2020 Julho | 17 | 4 | 21 |
2020 Junho | 12 | 16 | 28 |
2020 Maio | 25 | 14 | 39 |
2020 Abril | 0 | 3 | 3 |
2020 Março | 8 | 1 | 9 |
2020 Fevereiro | 0 | 1 | 1 |
2020 Janeiro | 0 | 4 | 4 |
2019 Dezembro | 0 | 3 | 3 |