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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Xanthogranuloma &#40;XG&#41; is a normolipemic non-Langerhans cell histiocytosis &#40;NLCH&#41; most commonly seen in childhood and generally designed as juvenile xanthogranuloma &#40;JXG&#41;&#46; Infrequently&#44; XG can occur in adulthood&#46; Both in adults and children&#44; XG usually presents as a solitary lesion&#46; Multiple lesions are rare in JXG and exceptional in adults&#46; The authors report a case of multiple adult xanthogranuloma &#40;MAXG&#41; of the face&#44; neck&#44; trunk&#44; abdomen&#44; and axillae&#44; with no extracutaneous involvement and no association with hematologic disease&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 38-year-old female&#44; with no relevant personal or family history of the disease&#44; was seen in October 2016 with multiple papules on her skin&#44; which she first noticed 18 months before&#46; Dermatologic examination showed more than 100 yellowish-brown&#44; smooth&#44; firm papules with diameters of 1&#8211;3<span class="elsevierStyleHsp" style=""></span>mm on the face&#44; neck&#44; thorax&#44; abdomen&#44; and axillae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; two larger elements&#44; standing out in the outer corner of the right eye and in the homolateral nasogenian groove&#46; The lesions were asymptomatic and the general physical examination &#40;including ophthalmologic&#44; cardiopulmonary&#44; and neurologic&#41; was normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The diagnostic hypotheses of syringomas&#44; sarcoidosis&#44; xanthomas&#44; and histiocytosis were considered&#44; and two lesions were excised for histopathologic evaluation&#46; This disclosed&#44; in both specimens&#44; a circumscribed dense dermal cellular infiltrate composed of large histiocytes&#44; mostly exhibiting xanthomized cytoplasm&#44; accompanied by multinucleated giant cells&#44; including some of the Touton type&#46; Interspersed inflammatory cells were also present&#44; mostly small lymphocytes with occasional neutrophils and some eosinophils &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46; Immunohistochemical evaluation documented absence of S100 protein&#44; and CD1a immunoreactivity and diffuse CD68 positivity&#44; supporting the diagnosis of XG&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">General laboratorial and imaging evaluation &#40;including &#946;2 microglobulin&#44; serum protein electrophoresis&#44; skeletal and thorax X-ray&#44; and abdominopelvic echography&#41; showed no abnormalities&#46; On the basis of the clinico-laboratorial and imaging findings&#44; the diagnosis of MAXG was obtained&#46; Ablation of the larger and cosmetically more-disturbing lesions by CO<span class="elsevierStyleInf">2</span> laser or electrosurgery was performed&#44; with good results&#46; During the follow-up period of almost two years&#44; the untreated cutaneous lesions persisted&#44; with no development of extracutaneous lesions nor hematologic alterations&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">XG is the most common type of NLCH&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The presentation of XG in adulthood is infrequent&#44; occurring generally in the 3rd or 4th decades of life&#44; without gender predominance&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> As in JXG&#44; most cases of adult XG manifest as a solitary papule or nodule on the face&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The occurrence of multiple XG lesions in adults is rare&#46; MAXG is defined by more than five XGs in patients over 14 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> According to these criteria&#44; 118 cases of MAXG have been reported from 1969 to 2004&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The etiopathogenesis of MAXG is unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">JXG and MAXG exhibit identical histologic and immunohistochemical findings&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Mature lesions show&#44; as in the present case&#44; a circumscribed nodular dermal proliferation composed of xanthomized histiocytes&#44; characteristically accompanied by Touton multinucleated cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;4</span></a> The histiocytic nature of the proliferation is confirmed by their CD68 positivity and absence of S100 protein&#44; as well as CD1a immunoreactivity&#44; with variable expression of factor XIIIa&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> Nevertheless&#44; these microscopic and immunochemical findings are not pathognomonic for XG and&#44; in the present patient&#44; other forms of adult NLCH presenting with multiple lesions needed to be excluded&#44; namely Erdheim&#8211;Chester disease &#40;ECD&#41;&#44; as well as eruptive disseminated histiocytoma &#40;EDG&#41;&#44; and more remotely&#44; disseminated xanthoma &#40;DX&#41; and multicentric reticulohistiocytosis &#40;RM&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The absence of skeletal abnormalities allowed to exclude ECD&#46; In EDG&#44; the lesions do not contain Touton cells&#46; These can&#44; however&#44; occur in DX&#44; but in the present patient no linear periflexural lesions&#44; which characterize DX&#44; were present&#46; In RM cutaneous lesions are acrally located&#44; accompanied by arthropathy and microscopically characterized by large multinucleated ground-glass cells&#44; aspects absent in the present case&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Clinically&#44; MAXG presents as yellow-orange or brownish papules and&#47;or nodules distributed on the trunk&#44; face&#44; neck&#44; and less frequently&#44; the limbs&#46; More than 10 lesions are present in only about 6&#37; of the reported cases&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In contrast with JXG&#44; in which ocular and&#44; less frequently&#44; other organ involvement may occur&#44; MAXG does not seem to evolve with extracutaneous histiocytic infiltration&#46; Accordingly&#44; exhaustive systemic investigation is not recommended in every patient&#46; Nevertheless&#44; as in JXG&#44; MAXG can be a marker of malignant blood disease&#44; a possibility that should be considered whenever B symptoms and&#47;or alterations of the electrophoretic proteinogram occur&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#8211;5</span></a> These&#44; as well as full blood tests&#44; were systematically absent&#47;negative in the present patient during the almost two years of follow-up&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">As spontaneous regression of the lesions in MAXG is less probable than in JXG&#44; surgical excision&#44; electrosurgery&#44; ablation by CO<span class="elsevierStyleInf">2</span> laser&#44; or systemic retinoids &#8211; namely isotretinoin &#8211; have been recommended as treatments whenever lesions are numerous&#44; cause discomfort&#44; or are unesthetic&#46; In the present patient&#44; a female of child-bearing age&#44; the larger papules were treated iteratively with CO<span class="elsevierStyleInf">2</span> laser or electrosurgery&#44; with a good cosmetic result&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; MAXG is a rare type of adult normolipemic NLCH&#44; whose significance is insufficiently known&#44; and is occasionally associated with hematologic malignancy that occur simultaneously&#44; preceded by or following the diagnosis of this histiocytosis&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> thereby requiring a focused and long-term follow-up of the patients&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contribution</span><p id="par0065" class="elsevierStylePara elsevierViewall">Renata da Costa Almeida&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">&#211;scar Tellechea&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Mariana Pinho Pereira&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Rosa Cristina Correia Mascarenhas&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
Multiple adult xanthogranuloma
Renata da Costa Almeidaa,
Autor para correspondência
renatadacostaalmeida@gmail.com

Corresponding author.
, Óscar Tellecheab,c, Mariana Pinho Pereirad, Rosa Cristina Correia Mascarenhasc
a Physician Assistant in Family Medicine, Portugal
b Dermatology Service, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal
c Dermatology Service, Hospital Distrital da Figueira da Foz, Figueira da Foz, Portugal
d Physician Assistant in Family Medicine, Unidade de Cuidados de Saúde Primários Litoral, Alfeizerão, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Xanthogranuloma &#40;XG&#41; is a normolipemic non-Langerhans cell histiocytosis &#40;NLCH&#41; most commonly seen in childhood and generally designed as juvenile xanthogranuloma &#40;JXG&#41;&#46; Infrequently&#44; XG can occur in adulthood&#46; Both in adults and children&#44; XG usually presents as a solitary lesion&#46; Multiple lesions are rare in JXG and exceptional in adults&#46; The authors report a case of multiple adult xanthogranuloma &#40;MAXG&#41; of the face&#44; neck&#44; trunk&#44; abdomen&#44; and axillae&#44; with no extracutaneous involvement and no association with hematologic disease&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 38-year-old female&#44; with no relevant personal or family history of the disease&#44; was seen in October 2016 with multiple papules on her skin&#44; which she first noticed 18 months before&#46; Dermatologic examination showed more than 100 yellowish-brown&#44; smooth&#44; firm papules with diameters of 1&#8211;3<span class="elsevierStyleHsp" style=""></span>mm on the face&#44; neck&#44; thorax&#44; abdomen&#44; and axillae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; two larger elements&#44; standing out in the outer corner of the right eye and in the homolateral nasogenian groove&#46; The lesions were asymptomatic and the general physical examination &#40;including ophthalmologic&#44; cardiopulmonary&#44; and neurologic&#41; was normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The diagnostic hypotheses of syringomas&#44; sarcoidosis&#44; xanthomas&#44; and histiocytosis were considered&#44; and two lesions were excised for histopathologic evaluation&#46; This disclosed&#44; in both specimens&#44; a circumscribed dense dermal cellular infiltrate composed of large histiocytes&#44; mostly exhibiting xanthomized cytoplasm&#44; accompanied by multinucleated giant cells&#44; including some of the Touton type&#46; Interspersed inflammatory cells were also present&#44; mostly small lymphocytes with occasional neutrophils and some eosinophils &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46; Immunohistochemical evaluation documented absence of S100 protein&#44; and CD1a immunoreactivity and diffuse CD68 positivity&#44; supporting the diagnosis of XG&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">General laboratorial and imaging evaluation &#40;including &#946;2 microglobulin&#44; serum protein electrophoresis&#44; skeletal and thorax X-ray&#44; and abdominopelvic echography&#41; showed no abnormalities&#46; On the basis of the clinico-laboratorial and imaging findings&#44; the diagnosis of MAXG was obtained&#46; Ablation of the larger and cosmetically more-disturbing lesions by CO<span class="elsevierStyleInf">2</span> laser or electrosurgery was performed&#44; with good results&#46; During the follow-up period of almost two years&#44; the untreated cutaneous lesions persisted&#44; with no development of extracutaneous lesions nor hematologic alterations&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">XG is the most common type of NLCH&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The presentation of XG in adulthood is infrequent&#44; occurring generally in the 3rd or 4th decades of life&#44; without gender predominance&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> As in JXG&#44; most cases of adult XG manifest as a solitary papule or nodule on the face&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The occurrence of multiple XG lesions in adults is rare&#46; MAXG is defined by more than five XGs in patients over 14 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> According to these criteria&#44; 118 cases of MAXG have been reported from 1969 to 2004&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The etiopathogenesis of MAXG is unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">JXG and MAXG exhibit identical histologic and immunohistochemical findings&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Mature lesions show&#44; as in the present case&#44; a circumscribed nodular dermal proliferation composed of xanthomized histiocytes&#44; characteristically accompanied by Touton multinucleated cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;4</span></a> The histiocytic nature of the proliferation is confirmed by their CD68 positivity and absence of S100 protein&#44; as well as CD1a immunoreactivity&#44; with variable expression of factor XIIIa&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> Nevertheless&#44; these microscopic and immunochemical findings are not pathognomonic for XG and&#44; in the present patient&#44; other forms of adult NLCH presenting with multiple lesions needed to be excluded&#44; namely Erdheim&#8211;Chester disease &#40;ECD&#41;&#44; as well as eruptive disseminated histiocytoma &#40;EDG&#41;&#44; and more remotely&#44; disseminated xanthoma &#40;DX&#41; and multicentric reticulohistiocytosis &#40;RM&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The absence of skeletal abnormalities allowed to exclude ECD&#46; In EDG&#44; the lesions do not contain Touton cells&#46; These can&#44; however&#44; occur in DX&#44; but in the present patient no linear periflexural lesions&#44; which characterize DX&#44; were present&#46; In RM cutaneous lesions are acrally located&#44; accompanied by arthropathy and microscopically characterized by large multinucleated ground-glass cells&#44; aspects absent in the present case&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Clinically&#44; MAXG presents as yellow-orange or brownish papules and&#47;or nodules distributed on the trunk&#44; face&#44; neck&#44; and less frequently&#44; the limbs&#46; More than 10 lesions are present in only about 6&#37; of the reported cases&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In contrast with JXG&#44; in which ocular and&#44; less frequently&#44; other organ involvement may occur&#44; MAXG does not seem to evolve with extracutaneous histiocytic infiltration&#46; Accordingly&#44; exhaustive systemic investigation is not recommended in every patient&#46; Nevertheless&#44; as in JXG&#44; MAXG can be a marker of malignant blood disease&#44; a possibility that should be considered whenever B symptoms and&#47;or alterations of the electrophoretic proteinogram occur&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#8211;5</span></a> These&#44; as well as full blood tests&#44; were systematically absent&#47;negative in the present patient during the almost two years of follow-up&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">As spontaneous regression of the lesions in MAXG is less probable than in JXG&#44; surgical excision&#44; electrosurgery&#44; ablation by CO<span class="elsevierStyleInf">2</span> laser&#44; or systemic retinoids &#8211; namely isotretinoin &#8211; have been recommended as treatments whenever lesions are numerous&#44; cause discomfort&#44; or are unesthetic&#46; In the present patient&#44; a female of child-bearing age&#44; the larger papules were treated iteratively with CO<span class="elsevierStyleInf">2</span> laser or electrosurgery&#44; with a good cosmetic result&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; MAXG is a rare type of adult normolipemic NLCH&#44; whose significance is insufficiently known&#44; and is occasionally associated with hematologic malignancy that occur simultaneously&#44; preceded by or following the diagnosis of this histiocytosis&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> thereby requiring a focused and long-term follow-up of the patients&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contribution</span><p id="par0065" class="elsevierStylePara elsevierViewall">Renata da Costa Almeida&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">&#211;scar Tellechea&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Mariana Pinho Pereira&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Rosa Cristina Correia Mascarenhas&#58; Approval of the final version of the manuscript&#59; composition of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; design of the study&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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ISSN: 03650596
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