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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pioderma gangrenoso &#40;PG&#41; &#233; doen&#231;a cr&#244;nica caracterizada por &#250;lceras cut&#226;neas recorrentes&#46; O PG foi descrito pela primeira vez por Brocq<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a> e nomeado por Brunsting et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a> Ao contr&#225;rio do seu nome&#44; posteriormente entendeu&#8208;se que se trata de dermatose neutrof&#237;lica ass&#233;ptica&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a> A incid&#234;ncia mundial de PG &#233; estimada em 3&#8208;10&#47;1&#46;000&#46;000&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Em sua etiopatogenia&#44; acredita&#8208;se que a disfun&#231;&#227;o de neutr&#243;filos&#44; a expans&#227;o clonal de c&#233;lulas T&#44; mediadores inflamat&#243;rios como interleucina &#40;IL&#41;&#8208;17&#44; IL&#8208;23 e predisposi&#231;&#227;o gen&#233;tica desempenhem papel relevante&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a> O PG tem quatro subgrupos prim&#225;rios&#58; cl&#225;ssico &#40;ulcerativo&#41;&#44; bolhoso&#44; pustuloso e vegetante&#46; Variantes mais raras incluem PG periestomal&#44; PG p&#243;s&#8208;operat&#243;rio e PG induzido por medicamentos&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a> No PG cl&#225;ssico&#44; que &#233; o tipo mais comum&#44; as les&#245;es come&#231;am como p&#250;stulas est&#233;reis e p&#225;pulas eritematosas e se transformam em les&#245;es ulcerativas dolorosas&#46; Les&#245;es com apar&#234;ncia viol&#225;cea e bordas elevadas bem definidas s&#227;o t&#237;picas do PG cl&#225;ssico&#46; As les&#245;es apresentam cicatrizes atr&#243;ficas cribriformes ou em forma de peneira&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">7&#44;8</span></a> Patergia&#44; a resposta exagerada ap&#243;s pequenos traumas cut&#226;neos&#44; &#233; observada em aproximadamente um ter&#231;o dos pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a> Como as investiga&#231;&#245;es laboratoriais e os achados histopatol&#243;gicos n&#227;o s&#227;o distintos no PG&#44; o diagn&#243;stico &#233; feito excluindo&#8208;se outras doen&#231;as inflamat&#243;rias da pele que causam ulcera&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> Su et al&#46; sugeriram crit&#233;rios diagn&#243;sticos para PG em 2004&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> De acordo com o consenso Delphi recentemente definido&#44; a presen&#231;a de infiltra&#231;&#227;o de neutr&#243;filos na histopatologia em bi&#243;psia retirada da borda da &#250;lcera &#233; um crit&#233;rio importante que deve ser atendido&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a> O PG pode estar associado a outras condi&#231;&#245;es em 50&#37;&#8208;75&#37; dos pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> As associa&#231;&#245;es mais comuns s&#227;o doen&#231;as inflamat&#243;rias intestinais &#40;DII&#41;&#44; artrite e dist&#250;rbios hematol&#243;gicos&#46; Al&#233;m disso&#44; o PG pode estar associado a s&#237;ndromes como PAPA &#40;artrite piog&#234;nica&#44; PG&#44; acne&#41;&#44; PASH &#40;PG&#44; acne&#44; hidradenite supurativa &#91;HS&#93;&#41;&#44; PASS &#40;PG&#44; acne conglobata&#44; HS&#44; espondiloartropatias soropositivas&#41;&#44; PAPASH &#40;artrite piog&#234;nica&#44; PG&#44; acne&#44; HS&#41; e PsAPASH &#40;artrite psori&#225;sica&#44; PG&#44; acne&#44; HS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> N&#227;o h&#225; tratamento de refer&#234;ncia para o PG&#46; O tratamento deve ser estruturado de acordo com o n&#250;mero de les&#245;es&#44; tamanho&#44; localiza&#231;&#227;o&#44; presen&#231;a de doen&#231;as associadas e comorbidades do paciente&#46; Os pilares fundamentais do tratamento incluem evitar fatores desencadeantes&#44; cuidado adequado da les&#227;o&#44; controle da dor&#44; terapias imunomoduladoras t&#243;picas&#44; sist&#234;micas e direcionadas&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">O objetivo do presente estudo foi avaliar as caracter&#237;sticas demogr&#225;ficas e cl&#237;nicas dos pacientes com PG&#44; bem como os fatores que afetam as prefer&#234;ncias e respostas ao tratamento&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Materiais e m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Foi realizado estudo multic&#234;ntrico que incluiu 12 centros de cuidados terci&#225;rios de oito prov&#237;ncias diferentes da Turquia&#46; Foram avaliados retrospectivamente os pacientes acompanhados entre os anos de 2012 a 2022 com diagn&#243;stico de PG de acordo com os crit&#233;rios diagn&#243;sticos sugeridos por Su et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> no qual dois crit&#233;rios maiores &#40;&#250;lceras necrosantes dolorosas de r&#225;pida progress&#227;o com bordas irregulares vermelho&#8208;viol&#225;ceas elevadas e exclus&#227;o de outras causas de ulcera&#231;&#227;o cut&#226;nea&#41; e dois crit&#233;rios menores &#40;desenvolvimento de &#250;lcera no local de trauma menor sugerindo presen&#231;a de patergia ou achados cl&#237;nicos de cicatrizes cribriformes&#44; presen&#231;a de doen&#231;a sist&#234;mica associada ao PG&#44; achado histopatol&#243;gico de infiltra&#231;&#227;o est&#233;ril de neutr&#243;filos na derme&#44; resposta r&#225;pida &#224; terapia sist&#234;mica com esteroides&#41; deveriam ser atendidos&#46; Foram compilados dados de todos os pacientes com PG &#62;<span class="elsevierStyleHsp" style=""></span>18 anos dos centros de estudo&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A aprova&#231;&#227;o do Comit&#234; de &#201;tica n&#176; E1&#8208;22&#8208;2782 foi obtida do Ankara Bilkent City Hospital antes do estudo &#40;17&#46;08&#46;2022&#41;&#46; O presente estudo foi conduzido de acordo com os princ&#237;pios &#233;ticos da Declara&#231;&#227;o de Helsinque&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Para todos os tratamentos&#44; a cicatriza&#231;&#227;o de feridas &#8805; 75&#37; como par&#226;metro de desfecho foi avaliada como &#8220;boa resposta&#8221;&#46; Benef&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>75&#37; foi avaliado como &#8220;resposta deficiente a moderada&#8221; no presente estudo&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">An&#225;lise estat&#237;stica</span><p id="par0035" class="elsevierStylePara elsevierViewall">Os dados foram analisados utilizando SPSS&#47;IBM para Windows 23&#46;0 &#40;Chicago&#44; IL&#44; EUA&#41;&#46; Estat&#237;sticas descritivas como n&#250;mero e porcentagem para vari&#225;veis categ&#243;ricas e m&#233;dia&#44; mediana&#44; desvio padr&#227;o e intervalo interquartil &#40;IIQ&#41; para vari&#225;veis num&#233;ricas foram utilizadas para descrever a amostra&#46; O teste de signific&#226;ncia de qui&#8208;quadrado ou teste exato de Fisher foi utilizado para comparar vari&#225;veis categ&#243;ricas&#44; e o teste <span class="elsevierStyleItalic">t</span> de Student ou teste U de Mann&#8208;Whitney foi utilizado para comparar vari&#225;veis num&#233;ricas&#46; Os testes de correla&#231;&#227;o de Pearson e Spearman foram utilizados para avaliar a correla&#231;&#227;o entre duas vari&#225;veis num&#233;ricas&#46; Vari&#225;veis com valores de p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;2 foram avaliadas posteriormente com an&#225;lise de regress&#227;o log&#237;stica multivariada para identificar preditores independentes de resposta ao tratamento&#46; O ajuste do modelo foi avaliado pelo teste de Hosmer&#8208;Lemeshow&#46; O n&#237;vel de signific&#226;ncia estat&#237;stica foi determinado como p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 para todas as an&#225;lises&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Durante a an&#225;lise explorat&#243;ria&#44; verificou&#8208;se que pacientes com PG positivo para patergia e pacientes com PG com idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30 anos apresentavam caracter&#237;sticas cl&#237;nicas distintas e respostas ao tratamento significantes&#46; A escolha do ponto de corte de idade de 30 anos foi baseada tanto em dados bibliogr&#225;ficos &#40;a idade definida como o ponto de corte te&#243;rico entre a idade adulta emergente e a idade adulta estabelecida&#41;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">11&#44;12</span></a> quanto em evid&#234;ncias &#40;melhor potencial na previs&#227;o de m&#250;ltiplas doen&#231;as&#44; <span class="elsevierStyleItalic">endpoints</span> espec&#237;ficos de pacientes e desfechos utilizando considera&#231;&#245;es de infer&#234;ncia estat&#237;stica&#41;&#46; Optou&#8208;se por denominar o PG que se inicia antes dos 30 anos como PG de in&#237;cio precoce e &#8805; 30 anos como PG de in&#237;cio tardio no presente estudo&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Resultados</span><p id="par0045" class="elsevierStylePara elsevierViewall">O presente estudo incluiu 143 &#40;59&#44;8&#37;&#41; mulheres e 96 &#40;40&#44;2&#37;&#41; homens&#44; totalizando 239 pacientes&#46; A idade m&#233;dia dos pacientes foi de 54&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;4 anos&#46; A m&#233;dia de idade de in&#237;cio da doen&#231;a foi de 48&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;1 anos&#46; A dura&#231;&#227;o da doen&#231;a foi determinada como valor mediano de 24 meses &#40;IQR 6&#8208;84&#59; m&#237;n&#8208;m&#225;x&#58; 1&#8208;366&#41;&#46; Os dados demogr&#225;ficos dos pacientes e informa&#231;&#245;es de hospitaliza&#231;&#227;o s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; As caracter&#237;sticas das les&#245;es observadas nos pacientes s&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46; O n&#250;mero de pacientes com PG do tipo ulcerativo foi de 203 &#40;85&#37;&#41;&#44; representando o subtipo mais frequente&#46; Os subtipos de PG observados nos pacientes do presente estudo s&#227;o mostrados na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Comorbidades associadas ao PG</span><p id="par0050" class="elsevierStylePara elsevierViewall">O n&#250;mero de pacientes com pelo menos uma comorbidade associada ao PG foi 123 &#40;51&#44;5&#37;&#41;&#46; A idade de in&#237;cio da doen&#231;a foi mais precoce em pacientes com comorbidade relacionada ao PG em compara&#231;&#227;o com aqueles sem comorbidade &#40;45&#44;9 <span class="elsevierStyleItalic">vs</span>&#46; 50&#44;7 anos&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;048&#41;&#46; Artrite inflamat&#243;ria foi observada em 45 &#40;18&#44;8&#37;&#41; pacientes&#46; DII foi encontrada em 38 &#40;15&#44;9&#37;&#41; pacientes&#46; A HS estava presente em 17 &#40;7&#44;1&#37;&#41; pacientes&#46; A frequ&#234;ncia de doen&#231;a hematol&#243;gica foi de 6&#44;7&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41;&#46; As doen&#231;as hematol&#243;gicas observadas nos pacientes foram MGUS &#40;gamopatia monoclonal de significado indeterminado&#41;&#44; s&#237;ndrome mielodispl&#225;sica&#44; linfoma e leucemia&#46; Neoplasia maligna s&#243;lida estava presente em 14 &#40;5&#44;9&#37;&#41; pacientes&#46; S&#237;ndromes autoinflamat&#243;rias foram encontradas em nove &#40;3&#44;8&#37;&#41; pacientes &#40;PAPA&#44; PASH&#44; PAPASH&#41;&#46; Em pacientes com doen&#231;a autoinflamat&#243;ria&#44; as frequ&#234;ncias do g&#234;nero masculino&#44; hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; envolvimento de m&#250;ltiplas regi&#245;es e envolvimento de membros superiores foram maiores&#44; bem como a presen&#231;a de di&#226;metro maior na les&#227;o e maior n&#250;mero de hospitaliza&#231;&#245;es em compara&#231;&#227;o com aqueles sem doen&#231;a autoinflamat&#243;ria &#40;valores de p respectivamente 0&#44;019&#44; &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#44; &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#44; 0&#44;004&#44; 0&#44;006 e 0&#44;025&#41;&#46; Al&#233;m disso&#44; esses pacientes eram mais jovens e a idade de in&#237;cio da doen&#231;a era menor &#40;ambos p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; As comorbidades associadas ao PG s&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Patergia foi detectada em 55 &#40;23&#37;&#41; pacientes e foi negativa em 140 &#40;58&#44;6&#37;&#41;&#46; Em 44 &#40;18&#44;4&#37;&#41; pacientes&#44; o estado de patergia n&#227;o foi relatado&#46; Dor estava presente em 218 &#40;91&#44;2&#37;&#41; pacientes&#46; Os achados laboratoriais e histopatol&#243;gicos dos pacientes s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Tratamentos recebidos pelos pacientes</span><p id="par0060" class="elsevierStylePara elsevierViewall">Todos os pacientes tiveram as les&#245;es cuidadas&#46; Os tratamentos t&#243;picos mais utilizados foram esteroides &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>163&#59; 68&#44;2&#37;&#41;&#44; curativos sint&#233;ticos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#59; 30&#44;5&#37;&#41; e tacrolimus &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#59; 16&#44;7&#37;&#41;&#46; Como a maioria dos pacientes que receberam tratamento t&#243;pico tamb&#233;m recebeu tratamento sist&#234;mico&#44; as respostas aos tratamentos t&#243;picos n&#227;o puderam ser avaliadas no presente estudo&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">O tempo m&#233;dio entre o diagn&#243;stico e o in&#237;cio do tratamento sist&#234;mico foi de um m&#234;s &#40;IIQ 0&#44;5&#8208;3&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Tratamentos sist&#234;micos</span><p id="par0070" class="elsevierStylePara elsevierViewall">Esteroides sist&#234;micos foram o tratamento para 181 &#40;75&#44;7&#37;&#41; pacientes&#46; Desses&#44; 92 &#40;50&#44;8&#37;&#41; usaram esteroide sist&#234;mico como agente sist&#234;mico &#250;nico&#44; enquanto 89 &#40;49&#44;2&#37;&#41; usaram pelo menos um agente imunossupressor al&#233;m dos esteroides&#46; As caracter&#237;sticas desses dois grupos s&#227;o comparadas na <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">A dose m&#233;dia de esteroides foi de 48<span class="elsevierStyleHsp" style=""></span>mg &#40;IIQ 40&#8208;60&#41; de equivalente de metilprednisolona&#46; A dura&#231;&#227;o m&#233;dia do tratamento foi de 60 dias &#40;IIQ 30&#8208;100&#41;&#46; N&#227;o foi encontrada correla&#231;&#227;o entre a dose de esteroide e o benef&#237;cio do tratamento &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;71&#41;&#46; Boa resposta ao tratamento foi obtida em 46&#44;4&#37; dos pacientes&#46; O intervalo de tempo entre o diagn&#243;stico e o in&#237;cio do tratamento sist&#234;mico correlacionou&#8208;se inversamente com o benef&#237;cio do tratamento &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#59; r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#44;21&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">A an&#225;lise univariada das caracter&#237;sticas dos pacientes que responderam bem ao tratamento sist&#234;mico com esteroides &#233; mostrada na <a class="elsevierStyleCrossRef" href="#tbl0025">tabela 5</a>&#46; Uma an&#225;lise de regress&#227;o log&#237;stica multivariada adicional foi realizada &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">tabela 6</a>&#41;&#46; Aus&#234;ncia de envolvimento de membros superiores &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;041&#41;&#44; presen&#231;a de les&#227;o &#250;nica &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;019&#41;&#44; idade de in&#237;cio da doen&#231;a &#8805; 30 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; aus&#234;ncia de leucocitose &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;012&#41;&#44; cultura negativa de les&#227;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; e patergia negativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41; foram determinados como os fatores independentes que influenciam as respostas ao tratamento sist&#234;mico com esteroides na an&#225;lise multivariada&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Oitenta e cinco &#40;35&#44;6&#37;&#41; pacientes usaram ciclosporina&#46; A mediana da dose de ciclosporina foi de 300<span class="elsevierStyleHsp" style=""></span>mg&#47;dia &#40;IIQ 237&#44;5&#8208;300&#41;&#46; A dura&#231;&#227;o m&#233;dia do tratamento foi de 100 dias &#40;60&#8208;200&#41;&#46; Recupera&#231;&#227;o completa foi observada em 19 &#40;22&#44;4&#37;&#41; pacientes&#46; N&#227;o foi observada correla&#231;&#227;o entre a dose de ciclosporina e o benef&#237;cio do tratamento &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;61&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Dez pacientes receberam tratamento com imunoglobulina intravenosa &#40;Ig IV&#41;&#44; e tr&#234;s desses pacientes obtiveram boa resposta&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Os tratamentos sist&#234;micos convencionais e Ig IV recebidos pelos pacientes e o benef&#237;cio relativo ao tratamento s&#227;o mostrados na <a class="elsevierStyleCrossRef" href="#tbl0035">tabela 7</a>&#46; Como alguns dos pacientes usaram mais de um tratamento sist&#234;mico convencional ou Ig IV simultaneamente&#44; n&#227;o foi poss&#237;vel fazer uma compara&#231;&#227;o direta em termos de efic&#225;cia entre esses tratamentos&#46;</p><elsevierMultimedia ident="tbl0035"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Tratamentos com biol&#243;gicos</span><p id="par0100" class="elsevierStylePara elsevierViewall">Agentes biol&#243;gicos foram utilizados em 44 &#40;18&#44;4&#37;&#41; pacientes&#46; O uso de agentes biol&#243;gicos foi mais comum em homens do que em mulheres &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41;&#44; em pacientes com hist&#243;rico familiar de doen&#231;as autoinflamat&#243;rias &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#41; e naqueles com envolvimento multirregional &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; envolvimento de cabe&#231;a e pesco&#231;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;019&#41;&#44; les&#245;es m&#250;ltiplas &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;024&#41;&#44; comorbidades &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41;&#44; cultura positiva de les&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;011&#41;&#44; patergia positiva &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#44; DII &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; HS &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;012&#41; e doen&#231;as autoinflamat&#243;rias &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Os pacientes em uso de tratamentos biol&#243;gicos eram mais jovens &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#44; tinham idade de in&#237;cio mais precoce &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; apresentavam mais les&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#44; mais hospitaliza&#231;&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e maior tempo de hospitaliza&#231;&#227;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; em compara&#231;&#227;o com aqueles que n&#227;o utilizaram tratamentos biol&#243;gicos&#46; A dura&#231;&#227;o mediana entre o tratamento convencional e o tratamento biol&#243;gico foi de 24 meses &#40;IIQ 12&#8208;60&#41;&#46; Os agentes biol&#243;gicos recebidos pelos pacientes e os dados da resposta obtida s&#227;o mostrados na <a class="elsevierStyleCrossRef" href="#tbl0040">tabela 8</a>&#46;</p><elsevierMultimedia ident="tbl0040"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Al&#233;m disso&#44; foram analisados grupos com patergia positiva&#47;negativa e pacientes com PG com idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30&#47;idade de in&#237;cio &#8805; 30&#44; que foram chamados de PG de in&#237;cio precoce e tardio no presente estudo&#46; As caracter&#237;sticas dos pacientes com patergia positiva e negativa s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#tbl0045">tabela 9</a>&#46; As caracter&#237;sticas dos pacientes com PG de in&#237;cio precoce s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#tbl0050">tabela 10</a>&#46;</p><elsevierMultimedia ident="tbl0045"></elsevierMultimedia><elsevierMultimedia ident="tbl0050"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discuss&#227;o</span><p id="par0110" class="elsevierStylePara elsevierViewall">Ao examinar as comorbidades associadas ao PG&#44; verificou&#8208;se que 51&#44;5&#37; dos pacientes apresentavam pelo menos uma comorbidade&#46; As comorbidades mais comuns nos pacientes foram artrite inflamat&#243;ria&#44; DII&#44; HS&#44; dist&#250;rbios hematol&#243;gicos e neoplasias malignas s&#243;lidas&#44; respectivamente&#46; Da mesma maneira&#44; em um estudo multic&#234;ntrico realizado por Ashchyan et al&#46;&#44; foram examinados dados de 356 pacientes com PG e foi determinado que 66&#44;9&#37; dos pacientes tinham comorbidades associadas&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> DII foi encontrada em 41&#37;&#44; artrite inflamat&#243;ria em 20&#44;5&#37;&#44; neoplasias malignas de &#243;rg&#227;os s&#243;lidos em 6&#44;5&#37;&#44; neoplasias malignas hematol&#243;gicas em 5&#44;9&#37;&#44; outros dist&#250;rbios hematol&#243;gicos em 4&#44;8&#37; e HS em 6&#44;2&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> No estudo de Langan et al&#46;&#44; doen&#231;as associadas ao PG foram detectadas em 33&#37; dos pacientes&#46; A doen&#231;a associada mais comum foi a DII&#44; observada em 20&#44;2&#37; dos casos&#44; seguida por artrite reumatoide &#40;11&#44;8&#37;&#41; e dist&#250;rbios hematol&#243;gicos &#40;3&#44;9&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a> S&#237;ndromes autoinflamat&#243;rias &#40;PAPA&#44; PASH&#44; PAPASH&#41; foram encontradas em 3&#44;8&#37; dos nossos pacientes&#46; Avaliando as caracter&#237;sticas desses pacientes&#44; notou&#8208;se que geralmente eram jovens e masculinos&#44; tinham idade de in&#237;cio da doen&#231;a mais precoce e tinham hist&#243;rico familiar de doen&#231;as autoinflamat&#243;rias&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">O achado laboratorial mais comum em nossos pacientes foi a eleva&#231;&#227;o dos n&#237;veis de prote&#237;na C&#8208;reativa &#40;PCR&#41;&#44; observada em 69&#44;7&#37;&#46; Anemia estava presente em 51&#44;9&#37; dos pacientes&#46; Em um estudo&#44; n&#237;veis elevados de PCR foram encontrados em 56&#44;3&#37; dos pacientes com PG&#59;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a> em outro estudo&#44; anemia foi observada em 45&#44;6&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">16</span></a> A presen&#231;a de crescimento microbiano em culturas de les&#245;es em 46&#44;4&#37; dos pacientes do presente estudo sugere que as les&#245;es do PG s&#227;o propensas a infec&#231;&#245;es secund&#225;rias&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Patergia foi identificada em 23&#37; dos nossos pacientes&#44; enquanto n&#227;o havia informa&#231;&#227;o sobre patergia em 18&#44;4&#37;&#46; Semelhante ao presente estudo&#44; no estudo de Binus et al&#46;&#44; a patergia foi registrada em 31&#44;1&#37;&#59;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a> no estudo de Ashchyan et al&#46;&#44; a taxa foi de 28&#44;1&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">O subtipo de PG mais comum nos pacientes do presente estudo foi o ulcerativo&#44; respons&#225;vel por 85&#37; dos casos&#44; seguido por PG bolhoso &#40;4&#44;2&#37;&#41; e pustuloso &#40;3&#44;8&#37;&#41;&#46; No estudo de Schosler et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a> a distribui&#231;&#227;o dos subtipos de PG foi 85&#44;9&#37; ulcerativo&#44; 3&#44;1&#37; bolhoso&#44; 6&#44;3&#37; periestomal&#44; 3&#44;1&#37; vegetante e 1&#44;6&#37; pustuloso&#44; o que foi semelhante ao presente estudo&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Os pacientes do presente estudo que receberam tratamento sist&#234;mico foram geralmente tratados de acordo com um algoritmo terap&#234;utico&#46; Em geral&#44; os corticosteroides sist&#234;micos foram o tratamento inicial para os pacientes do presente estudo&#46; Ciclosporina&#44; azatioprina&#44; dapsona&#44; mofetil micofenolato e colchicina foram utilizados como agentes poupadores de esteroides ou como agentes de tratamento adjuvantes&#46; Ig IV e medicamentos biol&#243;gicos foram utilizados como tratamentos de terceira linha&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Em muitos estudos&#44; os esteroides sist&#234;micos s&#227;o os mais comumente utilizados como tratamento de primeira linha<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">15&#44;17&#44;18</span></a>&#44; assim como no presente estudo&#46; Entretanto&#44; &#233; necess&#225;rio tratamento imunossupressor adicional para a maioria dos pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a> Quando foram examinadas as principais caracter&#237;sticas do grupo para o qual os esteroides sist&#234;micos por si s&#243; n&#227;o foram suficientes e foi necess&#225;rio tratamento imunossupressor adicional&#44; observou&#8208;se que a frequ&#234;ncia de envolvimento de m&#250;ltiplas regi&#245;es&#44; m&#250;ltiplas les&#245;es&#44; presen&#231;a de DII&#44; doen&#231;as autoinflamat&#243;rias e patergia positiva eram maiores &#40;todos p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; nesse grupo&#46; Os resultados surpreendentes da an&#225;lise de regress&#227;o multivariada que revelaram caracter&#237;sticas dos pacientes que apresentaram boa resposta aos esteroides sist&#234;micos foram idade de in&#237;cio da doen&#231;a &#8805; 30 anos&#44; patergia negativa&#44; aus&#234;ncia de leucocitose e cultura negativa de les&#245;es&#46; No presente estudo&#44; resposta completa foi alcan&#231;ada em 28&#44;7&#37; dos pacientes que usaram esteroides sist&#234;micos&#44; com mediana de dose de 48<span class="elsevierStyleHsp" style=""></span>mg de equivalente de metilprednisolona e dura&#231;&#227;o mediana de 60 dias&#46; Em estudo multic&#234;ntrico&#44; Herberger et al&#46; avaliaram as respostas ao tratamento de 121 pacientes com PG&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a> O tratamento inicial em 99&#37; desses pacientes foi esteroides sist&#234;micos na dose m&#233;dia de 80<span class="elsevierStyleHsp" style=""></span>mg&#46; O tratamento m&#233;dio com esteroides sist&#234;micos durou 4&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6 meses&#46; A resposta inicial aos esteroides sist&#234;micos foi obtida em 88&#37;&#46; Foi relatado que os pacientes que receberam tratamento para PG receberam em m&#233;dia dois tratamentos sist&#234;micos diferentes&#44; e a import&#226;ncia dos regimes combinados de tratamento no PG foi enfatizada&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Nos pacientes do presente estudo&#44; outro agente de tratamento frequentemente utilizado foi a ciclosporina&#44; administrada em m&#233;dia por 100 dias e na dose de 300<span class="elsevierStyleHsp" style=""></span>mg&#46; A ciclosporina utilizada em 35&#44;6&#37; dos pacientes do presente estudo obteve taxa de resposta completa de 22&#44;4&#37;&#46; Em ensaio cl&#237;nico randomizado multic&#234;ntrico comparando esteroides sist&#234;micos e ciclosporina no tratamento de PG&#44; um grupo recebeu 0&#44;75<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;dia de prednisolona em monoterapia&#44; enquanto outro grupo recebeu 4<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;dia de ciclosporina&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a> No final da 6&#170; semana&#44; n&#227;o foi observada diferen&#231;a entre os dois grupos em rela&#231;&#227;o a taxa de cura&#44; resposta ao tratamento&#44; dor e dura&#231;&#227;o da recorr&#234;ncia&#46; No entanto&#44; no 6&#176; m&#234;s&#44; n&#227;o foi observada cura em aproximadamente metade dos pacientes em ambos os grupos&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Azatioprina foi utilizada em 12&#44;6&#37; dos pacientes do presente estudo&#46; Entre esses pacientes&#44; 16&#44;7&#37; tiveram cura completa&#46; A azatioprina pode ser usada como agente poupador de esteroides no PG refrat&#225;rio ou como alternativa aos tratamentos de primeira linha&#46; Tamb&#233;m pode ser boa op&#231;&#227;o no PG acompanhado de DII&#46; A azatioprina geralmente surge como op&#231;&#227;o de tratamento bem tolerada e eficaz&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> No presente estudo&#44; o medicamento tamb&#233;m foi geralmente utilizado em pacientes com DII&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Dapsona foi utilizada em 7&#44;9&#37; dos pacientes do presente estudo&#46; Os dados referentes ao uso de dapsona no PG s&#227;o baseados em relatos de casos e s&#233;ries de casos&#46; No estudo de Din et al&#46;&#44; foram avaliadas as respostas ao tratamento de 27 pacientes que receberam terapia com dapsona para PG&#44; com 16&#37; dos pacientes apresentando resposta completa e 81&#37; apresentando resposta parcial&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">21</span></a> No presente estudo&#44; obteve&#8208;se boa resposta em 52&#44;6&#37; dos pacientes&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Colchicina foi utilizada em 7&#44;1&#37; dos pacientes do presente estudo&#46; Poucos casos foram relatados quanto ao uso de colchicina no PG&#46; Kontochristopoulos et al&#46; relataram r&#225;pida regress&#227;o em dois pacientes com PG refrat&#225;rio tratados com monoterapia com colchicina em baixas doses&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a> Cura completa foi observada em 5&#44;9&#37; dos pacientes do presente estudo&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Nove de nossos pacientes foram tratados com metotrexato&#46; Entre eles&#44; 77&#44;7&#37; obtiveram resposta de cura abaixo de 50&#37;&#46; O metotrexato &#233; um imunomodulador&#44; e as informa&#231;&#245;es sobre seu uso no PG baseiam&#8208;se em relatos de casos&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Mofetil micofenolato foi administrado em seis pacientes do presente estudo&#44; com dose m&#233;dia de 1&#44;5<span class="elsevierStyleHsp" style=""></span>g&#47;dia&#46; Entretanto&#44; todos os pacientes tiveram resposta ao tratamento inferior a 50&#37;&#46; O mofetil micofenolato &#233; considerado agente poupador de esteroides de segunda linha em pacientes com PG&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">No presente estudo&#44; dez pacientes receberam tratamento com Ig IV&#46; Todos eles receberam um a tr&#234;s ciclos de tratamento na dose de 2<span class="elsevierStyleHsp" style=""></span>g&#47;kg&#47;4 semanas&#46; Resposta ao tratamento &#8805; 75&#37; foi alcan&#231;ada em 30&#37; desses pacientes&#46; No estudo de Haag et al&#46;&#44; os autores compilaram a efic&#225;cia do tratamento com Ig IV em casos refrat&#225;rios&#44; identificando cura completa em 23 de 45 pacientes e resposta parcial ou n&#227;o responsividade em 22 pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Agentes biol&#243;gicos foram utilizados em 18&#44;4&#37; dos pacientes no presente estudo&#46; Descrevendo as caracter&#237;sticas fundamentais do grupo que necessita de transi&#231;&#227;o dos tratamentos convencionais para a terapia com agentes biol&#243;gicos&#44; verifica&#8208;se que esses inclu&#237;am pacientes com in&#237;cio precoce da doen&#231;a&#44; pacientes jovens&#44; masculinos&#44; com doen&#231;as autoinflamat&#243;rias&#44; com DII&#44; pacientes apresentando HS e aqueles que apresentavam patergia positiva&#46; A mediana do tempo de transi&#231;&#227;o do tratamento convencional para o tratamento biol&#243;gico nos pacientes do presente estudo foi de 24 meses&#46; Infliximabe&#44; o agente biol&#243;gico mais utilizado&#44; foi considerado para 15&#44;1&#37; desses pacientes&#46; O infliximabe foi administrado aos pacientes na dose aprovada usada na psor&#237;ase&#46; A mediana de dura&#231;&#227;o do tratamento foi de 12 meses&#44; e boa resposta foi obtida em 63&#44;9&#37; dos pacientes&#46; Adalimumabe foi o segundo agente biol&#243;gico mais utilizado nesses pacientes &#40;7&#44;9&#37;&#41;&#44; administrado em tr&#234;s doses diferentes&#58; a dose aprovada utilizada na psor&#237;ase&#44; 40<span class="elsevierStyleHsp" style=""></span>mg&#47;semana e 80<span class="elsevierStyleHsp" style=""></span>mg&#47;semana&#46; A dura&#231;&#227;o m&#233;dia do tratamento foi de 14 meses&#44; e a taxa de pacientes que responderam com &#8805; 75&#37; foi de 5&#44;2&#37;&#46; Tr&#234;s pacientes usaram etanercepte&#46; Os pacientes utilizaram a dose aprovada durante m&#233;dia de oito meses&#44; mas a resposta ao tratamento n&#227;o excedeu 50&#37;&#46; Infliximabe &#233; o &#250;nico agente anti&#8208;TNF cuja efic&#225;cia foi demonstrada no PG cl&#225;ssico por meio de um estudo randomizado duplo&#8208;cego controlado&#46; No estudo randomizado controlado por placebo conduzido por Brooklyn et al&#46;&#44; resposta parcial foi alcan&#231;ada em 48&#37; e resposta completa em 21&#37; ao final de seis semanas&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a> Em um estudo de fase 3&#44; aberto e multic&#234;ntrico&#44; a efic&#225;cia e a seguran&#231;a do adalimumabe no PG refrat&#225;rio foram investigadas e cura completa foi registrada em 54&#44;5&#37; ap&#243;s 26 semanas de tratamento&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">26</span></a> Abdallah et al&#46; realizaram uma revis&#227;o semissistem&#225;tica sobre o uso de inibidores de TNF&#8208;&#945; no PG&#46; Nenhuma diferen&#231;a foi encontrada entre infliximabe&#44; adalimumabe e etanercepte em termos de taxas de resposta parcial e completa&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">27</span></a> Em especial&#44; infliximabe e adalimumabe&#44; dois antagonistas do TNF&#8208;&#945; parecem ser boa op&#231;&#227;o para casos resistentes ou para evitar os efeitos colaterais em longo prazo dos esteroides sist&#234;micos ou da ciclosporina&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">27</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">No presente estudo&#44; houve quatro pacientes em uso de ustequinumabe&#44; com taxa de resposta de 25&#37;&#8208;75&#37;&#46; Em uma revis&#227;o semissistem&#225;tica&#44; a taxa de resposta completa foi de 71&#37; em pacientes tratados com ustequinumabe&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">Os inibidores de IL&#8208;1 utilizados no tratamento do PG s&#227;o anakinra e canaquinumabe&#46; Tr&#234;s pacientes com doen&#231;a autoinflamat&#243;ria utilizaram anakinra no presente estudo&#46; Apenas um desses pacientes obteve boa resposta&#46; Um paciente utilizou canaquinumabe no presente estudo&#44; o qual continuou o tratamento por 36 meses e respondeu ao tratamento com taxa de cura &#8805; 75&#37;&#46; Na revis&#227;o semissistem&#225;tica de Abdallah et al&#46;&#44; resposta completa foi alcan&#231;ada em 57&#37; dos pacientes &#40;IC 95&#37; de 45&#37;&#8208;68&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Tr&#234;s pacientes utilizaram secuquinumabe no presente estudo&#46; Enquanto dois pacientes responderam com taxa de cura de 25&#37; a 50&#37;&#44; o outro paciente respondeu com taxa de cura &#8805; 75&#37;&#46; Um paciente recebeu tratamento com risanquizumabe&#44; e obteve resposta de cura de 75&#37; ou mais ao final de quatro meses de tratamento&#46; Um paciente recebeu tratamento com ixequizumabe&#44; interrompido ao final de seis meses porque n&#227;o foi poss&#237;vel obter resposta adequada ao tratamento&#46; H&#225; relatos de casos indicando que secuquinumabe&#44; risanquizumabe e ixequizumabe s&#227;o eficazes no PG resistente&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">29&#8211;31</span></a>O presente estudo revelou dados convincentes sobre dois grupos espec&#237;ficos de pacientes&#46; Naqueles com patergia positiva&#44; havia maior taxa de hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; presen&#231;a de envolvimento de m&#250;ltiplas regi&#245;es&#44; maior n&#250;mero total e dura&#231;&#227;o total de hospitaliza&#231;&#245;es e maior taxa de presen&#231;a de doen&#231;a autoinflamat&#243;ria&#46; O grupo com patergia positiva tamb&#233;m diferiu significantemente do grupo com patergia negativa em rela&#231;&#227;o ao tratamento e respostas ao tratamento&#46; No grupo com patergia positiva&#44; a taxa de resposta aos esteroides sist&#234;micos foi significantemente menor&#44; a taxa de uso de imunossupressores sist&#234;micos adjuvantes foi alta e a taxa de uso de agentes biol&#243;gicos foi alta&#46; Outro grupo espec&#237;fico foi o PG de in&#237;cio precoce &#40;idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30&#41;&#44; no qual a hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; o envolvimento da cabe&#231;a e pesco&#231;o&#44; a presen&#231;a de DII e de doen&#231;a autoinflamat&#243;ria foram mais frequentes&#46; Al&#233;m disso&#44; no PG de in&#237;cio precoce&#44; a taxa de pacientes que responderam aos esteroides sist&#234;micos foi baixa&#44; e as taxas de uso de tratamentos imunossupressores adjuvantes e biol&#243;gicos foram significantemente altas&#46; Acredita&#8208;se ser necess&#225;rio considerar que pacientes com patergia positiva e PG de in&#237;cio precoce sejam mais resistentes ao tratamento&#44; necessitando de tratamentos mais complexos&#46; De fato&#44; &#233; crucial investigar a exist&#234;ncia de doen&#231;as autoinflamat&#243;rias coexistentes no momento do diagn&#243;stico em pacientes com patergia positiva e PG de in&#237;cio precoce&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Uma limita&#231;&#227;o do presente estudo &#233; a aus&#234;ncia de crit&#233;rios diagn&#243;sticos padr&#227;o para PG&#44; o que torna incerto se o diagn&#243;stico foi realizado com precis&#227;o em todos os casos&#46; Al&#233;m disso&#44; acredita&#8208;se que alguns dados possam ter sido perdidos&#44; pois o presente estudo abrange pacientes dos &#250;ltimos dez anos&#46; Em virtude da falta de qualquer escala para pontuar a gravidade da doen&#231;a&#44; as taxas de resposta foram baseadas na avalia&#231;&#227;o dos m&#233;dicos nos prontu&#225;rios dos pacientes&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclus&#245;es</span><p id="par0200" class="elsevierStylePara elsevierViewall">O PG &#233; doen&#231;a cr&#244;nica rara acompanhada de muitas comorbidades&#46; Embora os esteroides sist&#234;micos tenham sido suficientes em cerca de metade dos pacientes avaliados no presente estudo&#44; foram necess&#225;rios tratamentos imunossupressores adicionais na outra metade&#46; Presen&#231;a de m&#250;ltiplas les&#245;es&#44; envolvimento de m&#250;ltiplas regi&#245;es&#44; doen&#231;a autoinflamat&#243;ria e DII foram caracter&#237;sticas comuns dos pacientes que necessitaram de tratamento adicional com imunossupressores e biol&#243;gicos&#46; Al&#233;m disso&#44; acredita&#8208;se que a presen&#231;a de patergia positiva e PG de in&#237;cio precoce possam fornecer aos m&#233;dicos informa&#231;&#245;es sobre o curso e o progn&#243;stico da doen&#231;a&#44; e a mudan&#231;a para tratamentos avan&#231;ados mais precocemente&#44; nesses casos&#44; pode ser ben&#233;fica&#46; Acredita&#8208;se que os dados compilados no presente estudo multic&#234;ntrico&#44; com abrang&#234;ncia de dez anos em 12 hospitais terci&#225;rios na Turquia&#44; contribuir&#227;o para o conhecimento sobre essa doen&#231;a&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Suporte financeiro</span><p id="par0205" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Contribui&#231;&#227;o dos autores</span><p id="par0210" class="elsevierStylePara elsevierViewall">Funda Erduran&#58; Concep&#231;&#227;o e planejamento do estudo&#44; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o de dados&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Esra Ad&#305;&#351;en&#58; Concep&#231;&#227;o e planejamento do estudo&#44; obten&#231;&#227;o de dados&#44; supervis&#227;o&#44; revis&#227;o cr&#237;tica e edi&#231;&#227;o do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Y&#305;ld&#305;z Hayran&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">G&#252;ne&#351; G&#252;r Aksoy&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Erkan Alpsoy&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Leyla Baykal Sel&#231;uk&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Sibel Do&#287;an G&#252;nayd&#305;n&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">Ay&#231;a Cordan Yaz&#305;c&#305;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">Ay&#351;e &#214;ktem&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Malik G&#252;ng&#246;r&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">Elif Afacan&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Deniz Devrim Ku&#351;&#231;u&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">Leyla Elmas&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">K&#252;bra Aydo&#287;an&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Dilek Bayramg&#252;rler&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0285" class="elsevierStylePara elsevierViewall">Evren Odyakmaz Demirsoy&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Melih Akyol&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Rukiye G&#252;ner&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">Hilal Kaya Erdo&#287;an&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">Ersoy Acer&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0310" class="elsevierStylePara elsevierViewall">Tulin Ergun&#44; Sava&#351; Yayl&#305;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0315" class="elsevierStylePara elsevierViewall">Ferhan Bulut&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0320" class="elsevierStylePara elsevierViewall">Esra Sara&#231;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Ak&#305;n Akta&#351;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflito de interesses</span><p id="par0330" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pioderma gangrenoso &#40;PG&#41; &#233; doen&#231;a cr&#244;nica caracterizada por &#250;lceras cut&#226;neas recalcitrantes&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar as caracter&#237;sticas demogr&#225;ficas e cl&#237;nicas&#44; os tratamentos e fatores que afetam as respostas ao tratamento de pacientes com PG&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Foi realizado estudo multic&#234;ntrico em 12 centros de aten&#231;&#227;o terci&#225;ria&#46; Foram analisados retrospectivamente os dados dos pacientes acompanhados com diagn&#243;stico de PG entre os anos de 2012 a 2022&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos um total de 239 pacientes&#44; dos quais 143 eram do g&#234;nero feminino e 96 do g&#234;nero masculino&#44; com m&#233;dia de idade de 54&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;4 anos&#46; O tratamento mais comum foram esteroides sist&#234;micos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>181&#59; 75&#44;7&#37;&#41;&#46; Entre esses pacientes&#44; 50&#44;8&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>92&#41; utilizaram esteroides sist&#234;micos como &#250;nica terap&#234;utica&#44; enquanto 49&#44;2&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>89&#41; usaram pelo menos um agente imunossupressor adjuvante&#46; Os fatores independentes determinados na an&#225;lise de regress&#227;o que influenciaram positivamente a resposta aos esteroides sist&#234;micos foram idade de in&#237;cio da doen&#231;a &#8805; 30 anos&#44; patergia negativa&#44; aus&#234;ncia de leucocitose&#44; cultura de les&#227;o negativa&#44; presen&#231;a de les&#227;o &#250;nica e aus&#234;ncia de envolvimento dos membros superiores&#46; Agentes biol&#243;gicos foram utilizados em 18&#44;4&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#41; dos pacientes do presente estudo&#46; Tamb&#233;m foram analisados PG positivo para patergia e PG de in&#237;cio precoce &#40;idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30&#41; separadamente em virtude de suas caracter&#237;sticas cl&#237;nicas distintas que foram reveladas durante a an&#225;lise estat&#237;stica&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Natureza retrospectiva do presente estudo&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A an&#225;lise dos fatores que influenciam as respostas ao tratamento &#233; abordada no presente estudo&#46; Al&#233;m disso&#44; concluiu&#8208;se que a investiga&#231;&#227;o de doen&#231;as autoinflamat&#243;rias concomitantes com PG positivo para patergia e PG de in&#237;cio precoce &#233; necess&#225;ria&#44; e os pacientes desses dois grupos s&#227;o mais resistentes ao tratamento&#44; necessitando de tratamentos mais complexos&#46;</p></span>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Como citar este artigo&#58; Erduran F&#44; Ad&#305;&#351;en E&#44; Hayran Y&#44; Aksoy GG&#44; Alpsoy E&#44; Sel&#231;uk LB&#44; et al&#46; Analysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum&#58; a multicenter study of 239 patients&#46; An Bras Dermatol&#46; 2024&#59;99&#58;815&#8211;25&#46;</p>"
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      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Trabalho realizado no Ankara Bilkent City Hospital&#44; Ankara&#44; Turquia&#59; Faculdade de Medicina&#44; Gazi University&#44; Ankara&#44; Turquia&#59; Faculdade de Medicina&#44; Akdeniz University&#44; Antalya&#44; Turquia&#59; Faculdade de Medicina&#44; Karadeniz Technical University&#44; Trabzon&#44; Turquia&#59; Faculdade de Medicina&#44; Hacettepe University&#44; Ankara&#44; Turquia&#59; Faculdade de Medicina&#44; Mersin University&#44; Mersin&#44; Turquia&#59; Faculdade de Medicina&#44; Kocaeli University&#44; Kocaeli&#44; Turquia&#59; Faculdade de Medicina&#44; Sivas Cumhuriyet University&#44; Sivas&#44; Turquia&#59; Faculdade de Medicina&#44; Eski&#351;ehir Osmangazi University&#44; Eski&#351;ehir&#44; Turquia&#59; Faculdade de Medicina&#44; Marmara University&#44; Istambul&#44; Turquia e Faculdade de Medicina&#44; Ko&#231; University&#44; Istambul&#44; Turquia&#46;</p>"
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                  \t\t\t\t">Total&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">239</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">143 &#40;59&#44;8&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
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                  \t\t\t\t">96 &#40;40&#44;2&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
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                  \t\t\t\t">54&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;4</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade de in&#237;cio<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP &#40;anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;1</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Dura&#231;&#227;o da doen&#231;a &#40;meses&#41; &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;6&#8208;84&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Taxa de hospitaliza&#231;&#227;o&#44; n &#40;&#37;&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">187 &#40;78&#44;2&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
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                  \t\t\t\t">N&#250;mero de hospitaliza&#231;&#245;es</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uma vez&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">89 &#40;37&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Duas vezes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46 &#40;19&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tr&#234;s vezes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;9&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805; Quatro vezes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tempo total de hospitaliza&#231;&#227;o &#40;dias&#41;&#8208; Mediana &#40;IIQ&#41; &#40;m&#237;n&#8208;m&#225;x&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;12&#8208;39&#41; &#40;m&#237;n&#8208;m&#225;x&#58; 1&#8208;113&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Menor per&#237;odo de hospitaliza&#231;&#227;o &#40;dias&#41;&#8208; Mediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;6&#8208;14&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maior per&#237;odo de hospitaliza&#231;&#227;o &#40;dias&#41;&#8208; Mediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;5 &#40;10&#8208;23&#41;</td></tr></tbody></table>
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Extremidades inferiores&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">189 &#40;79&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">31 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">70 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cabe&#231;a&#8208;pesco&#231;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;3&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Outras &#40;mucosa oral&#44; regi&#227;o genital&#44; regi&#227;o gl&#250;tea&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Maior tamanho de les&#227;o &#40;cm&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#8208;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104 &#40;43&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&#8208;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">86 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">90 &#40;37&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">108 &#40;45&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&#8208;10 les&#245;es&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artrite inflamat&#243;ria &#40;artrite reumatoide&#44; artrite psori&#225;tica&#44; artrite gotosa&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;as hematol&#243;gicas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">16 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neoplasia maligna s&#243;lida&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Outras &#40;doen&#231;a de Beh&#231;et&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">51&#44;5<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">124 &#40;51&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neutrofilia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">104 &#40;43&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dist&#250;rbio eletrol&#237;tico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Compat&#237;vel com PG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Incompat&#237;vel com PG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Biopsia n&#227;o realizada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">44 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de dor</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Uma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&#250;ltiplas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;009</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;10&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cultura de les&#227;o</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;014</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">39 &#40;42&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Patergia</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;018</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16 &#40;17&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">29 &#40;32&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">76 &#40;82&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">60 &#40;67&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Leucocitose</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;032</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">33 &#40;35&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46 &#40;51&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">59 &#40;64&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">43 &#40;48&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Doen&#231;a autoinflamat&#243;ria</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;003</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">91 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">81 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Doen&#231;a inflamat&#243;ria intestinal</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;040</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">11 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">21 &#40;23&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">81 &#40;88&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">68 &#40;76&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Maior tamanho de les&#227;o</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;008</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">49 &#40;53&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30 &#40;33&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">43 &#40;46&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">59 &#40;66&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade&#44; m&#233;dia &#40;DP&#41; &#40;anos&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">56&#44;5 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">48&#44;7 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade de in&#237;cio da doen&#231;a &#40;DP&#41; &#40;anos&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dura&#231;&#227;o da doen&#231;a &#40;meses&#41;&#44; mediana &#40;IIQ&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a> Resposta deficiente a moderada&#44; n&#160;&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Patergia</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72 &#40;85&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Leucocitose</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;001</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;54&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">58 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;45&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Doen&#231;a autoinflamat&#243;ria</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;007</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;91&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Artrite inflamat&#243;ria</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;012</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">23 &#40;23&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">76 &#40;90&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">74 &#40;76&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tamanho da maior les&#227;o</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;002</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade de in&#237;cio da doen&#231;a &#40;anos&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;27&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;90&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70 &#40;72&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dura&#231;&#227;o da doen&#231;a&#44; meses</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;91&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;69&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;30&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">RR&#44; risco relativo&#59; IC&#44; intervalo de confian&#231;a&#46;</p>"
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            0 => array:2 [
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                0 => """
                  <table border="0" frame="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;sticas de pacientes com boa resposta aos esteroides sist&#234;micos</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RR</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IC 95&#37; para RR</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Inferior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de envolvimento dos membros superiores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;041&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de les&#227;o &#250;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade de in&#237;cio da doen&#231;a &#8805; 30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de leucocitose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cultura negativa de les&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patergia negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3706832.png"
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise de regress&#227;o log&#237;stica multivariada das caracter&#237;sticas dos pacientes com boa resposta aos esteroides sist&#234;micos</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0035"
        "etiqueta" => "Tabela 7"
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        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at7"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">IIQ&#44; intervalo interquartil&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Esteroides sist&#234;micos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ciclosporina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Azatioprina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dapsona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Colchicina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ig IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Micofenolato Mofetil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Talidomida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de pacientes usando&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">181 &#40;75&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;35&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dose&#44; mediana &#40;IIQ</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">a</span></span></a><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48 mg&#47;dia &#40;40&#8208;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">300 mg&#47;dia &#40;237&#44;5&#8208;300&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150 mg&#47;dia &#40;100&#8208;150&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150 mg&#47;dia &#40;100&#8208;150&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5 mg&#47;dia &#40;1&#8208;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 g&#47;kg&#47; 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero de pacientes recebendo tratamento&#44; n&#160;&#40;&#37;&#41;</th><th class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dura&#231;&#227;o m&#233;dia do tratamento &#40;meses&#41; &#40;IIQ&#41;</th><th class="td" title="\n
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                  \t\t\t\t  " colspan="5" align="center" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#8805; 75&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36 &#40;15&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">19 &#40;7&#44;9&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">R &#40;42&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;12&#8208;27&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">6 &#40;31&#44;6&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">4 &#40;21&#44;1&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">2 &#40;10&#44;5&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">2 &#40;10&#44;5&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">5 &#40;26&#44;3&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 mg&#47;semana &#40;47&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80 mg&#47;semana &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustequinumabe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Etanercepte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secuquinumabe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anakinra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100 mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Ixequizumabe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Canaquinumabe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">300 mg&#47;4&#8208;semanas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">68 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de envolvimento de m&#250;ltiplos locais&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">31 &#40;16&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero total de hospitaliza&#231;&#245;es&#44; mediana &#40;IIQ&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#8208;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#8208;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;043&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tempo total de interna&#231;&#227;o&#44; mediana &#40;IIQ&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27&#44;5 &#40;12&#8208;63&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">20 &#40;11&#44;5&#8208;34&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;046&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de doen&#231;a autoinflamat&#243;ria&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">5 &#40;9&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;2&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Esteroides sist&#234;micos &#43; agentes imunossupressores adicionais&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de pacientes com boa resposta aos esteroides sist&#234;micos &#40;taxa de resposta &#8805; 75&#37;&#41;&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Esteroides sist&#234;micos &#43; agentes imunossupressores adicionais&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de pacientes com boa resposta aos ester&#243;ides sist&#234;micos &#40;taxa de resposta &#8805; 75&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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Artigo original
Análise das características clínicas e fatores que afetam a resposta ao tratamento em pacientes com pioderma gangrenoso: estudo multicêntrico com 239 pacientes
Funda Erdurana,
Corresponding author
fnderdrn@mail.com

Autor para correspondência.
, Esra Adışenb, Yıldız Hayrana, Güneş Gür Aksoya, Erkan Alpsoyc, Leyla Baykal Selçukd, Sibel Doğan Günaydıne, Ayça Cordan Yazıcıf, Ayşe Öktemg, Malik Güngörc, Elif Afacanb, Deniz Devrim Kuşçug, Leyla Elmase, Kübra Aydoğanf, Dilek Bayramgürlerh, Evren Odyakmaz Demirsoyh, Melih Akyoli, Rukiye Yasak Güneri, Hilal Kaya Erdoğanj, Ersoy Acerj..., Tulin Ergunk, Savaş Yaylıl, Ferhan Bulutk, Esra Saraçl, Akın AktaşaVer más
a Departamento de Dermatologia, Ankara Bilkent City Hospital, Ankara, Turquia
b Departamento de Dermatologia, Faculdade de Medicina, Gazi University, Ankara, Turquia
c Departamento de Dermatologia, Faculdade de Medicina, Akdeniz University, Antalya, Turquia
d Departamento de Dermatologia, Faculdade de Medicina, Karadeniz Technical University, Trabzon, Turquia
e Departamento de Dermatologia, Faculdade de Medicina, Hacettepe University, Ankara, Turquia
f Departamento de Dermatologia, Faculdade de Medicina, Mersin University, Mersin, Turquia
g Departamento de Dermatologia, Faculdade de Medicina, Ankara University, Ankara, Turquia
h Departamento de Dermatologia, Faculdade de Medicina, Kocaeli University, Kocaeli, Turquia
i Departamento de Dermatologia, Faculdade de Medicina, Sivas Cumhuriyet University, Sivas, Turquia
j Departamento de Dermatologia, Faculdade de Medicina, Eskişehir Osmangazi University, Eskişehir, Turquia
k Departamento de Dermatologia, Faculdade de Medicina, Marmara Akdeniz University, İstambul, Turquia
l Departamento de Dermatologia, Faculdade de Medicina, Koç University, İstambul, Turquia
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            "etiqueta" => "g"
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            "entidad" => "Departamento de Dermatologia&#44; Faculdade de Medicina&#44; Kocaeli University&#44; Kocaeli&#44; Turquia"
            "etiqueta" => "h"
            "identificador" => "aff0035"
          ]
          8 => array:3 [
            "entidad" => "Departamento de Dermatologia&#44; Faculdade de Medicina&#44; Sivas Cumhuriyet University&#44; Sivas&#44; Turquia"
            "etiqueta" => "i"
            "identificador" => "aff0040"
          ]
          9 => array:3 [
            "entidad" => "Departamento de Dermatologia&#44; Faculdade de Medicina&#44; Eski&#351;ehir Osmangazi University&#44; Eski&#351;ehir&#44; Turquia"
            "etiqueta" => "j"
            "identificador" => "aff0045"
          ]
          10 => array:3 [
            "entidad" => "Departamento de Dermatologia&#44; Faculdade de Medicina&#44; Marmara Akdeniz University&#44; &#304;stambul&#44; Turquia"
            "etiqueta" => "k"
            "identificador" => "aff0050"
          ]
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            "entidad" => "Departamento de Dermatologia&#44; Faculdade de Medicina&#44; Ko&#231; University&#44; &#304;stambul&#44; Turquia"
            "etiqueta" => "l"
            "identificador" => "aff0055"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pioderma gangrenoso &#40;PG&#41; &#233; doen&#231;a cr&#244;nica caracterizada por &#250;lceras cut&#226;neas recorrentes&#46; O PG foi descrito pela primeira vez por Brocq<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a> e nomeado por Brunsting et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a> Ao contr&#225;rio do seu nome&#44; posteriormente entendeu&#8208;se que se trata de dermatose neutrof&#237;lica ass&#233;ptica&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a> A incid&#234;ncia mundial de PG &#233; estimada em 3&#8208;10&#47;1&#46;000&#46;000&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Em sua etiopatogenia&#44; acredita&#8208;se que a disfun&#231;&#227;o de neutr&#243;filos&#44; a expans&#227;o clonal de c&#233;lulas T&#44; mediadores inflamat&#243;rios como interleucina &#40;IL&#41;&#8208;17&#44; IL&#8208;23 e predisposi&#231;&#227;o gen&#233;tica desempenhem papel relevante&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a> O PG tem quatro subgrupos prim&#225;rios&#58; cl&#225;ssico &#40;ulcerativo&#41;&#44; bolhoso&#44; pustuloso e vegetante&#46; Variantes mais raras incluem PG periestomal&#44; PG p&#243;s&#8208;operat&#243;rio e PG induzido por medicamentos&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a> No PG cl&#225;ssico&#44; que &#233; o tipo mais comum&#44; as les&#245;es come&#231;am como p&#250;stulas est&#233;reis e p&#225;pulas eritematosas e se transformam em les&#245;es ulcerativas dolorosas&#46; Les&#245;es com apar&#234;ncia viol&#225;cea e bordas elevadas bem definidas s&#227;o t&#237;picas do PG cl&#225;ssico&#46; As les&#245;es apresentam cicatrizes atr&#243;ficas cribriformes ou em forma de peneira&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">7&#44;8</span></a> Patergia&#44; a resposta exagerada ap&#243;s pequenos traumas cut&#226;neos&#44; &#233; observada em aproximadamente um ter&#231;o dos pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a> Como as investiga&#231;&#245;es laboratoriais e os achados histopatol&#243;gicos n&#227;o s&#227;o distintos no PG&#44; o diagn&#243;stico &#233; feito excluindo&#8208;se outras doen&#231;as inflamat&#243;rias da pele que causam ulcera&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> Su et al&#46; sugeriram crit&#233;rios diagn&#243;sticos para PG em 2004&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> De acordo com o consenso Delphi recentemente definido&#44; a presen&#231;a de infiltra&#231;&#227;o de neutr&#243;filos na histopatologia em bi&#243;psia retirada da borda da &#250;lcera &#233; um crit&#233;rio importante que deve ser atendido&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a> O PG pode estar associado a outras condi&#231;&#245;es em 50&#37;&#8208;75&#37; dos pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> As associa&#231;&#245;es mais comuns s&#227;o doen&#231;as inflamat&#243;rias intestinais &#40;DII&#41;&#44; artrite e dist&#250;rbios hematol&#243;gicos&#46; Al&#233;m disso&#44; o PG pode estar associado a s&#237;ndromes como PAPA &#40;artrite piog&#234;nica&#44; PG&#44; acne&#41;&#44; PASH &#40;PG&#44; acne&#44; hidradenite supurativa &#91;HS&#93;&#41;&#44; PASS &#40;PG&#44; acne conglobata&#44; HS&#44; espondiloartropatias soropositivas&#41;&#44; PAPASH &#40;artrite piog&#234;nica&#44; PG&#44; acne&#44; HS&#41; e PsAPASH &#40;artrite psori&#225;sica&#44; PG&#44; acne&#44; HS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> N&#227;o h&#225; tratamento de refer&#234;ncia para o PG&#46; O tratamento deve ser estruturado de acordo com o n&#250;mero de les&#245;es&#44; tamanho&#44; localiza&#231;&#227;o&#44; presen&#231;a de doen&#231;as associadas e comorbidades do paciente&#46; Os pilares fundamentais do tratamento incluem evitar fatores desencadeantes&#44; cuidado adequado da les&#227;o&#44; controle da dor&#44; terapias imunomoduladoras t&#243;picas&#44; sist&#234;micas e direcionadas&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">O objetivo do presente estudo foi avaliar as caracter&#237;sticas demogr&#225;ficas e cl&#237;nicas dos pacientes com PG&#44; bem como os fatores que afetam as prefer&#234;ncias e respostas ao tratamento&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Materiais e m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Foi realizado estudo multic&#234;ntrico que incluiu 12 centros de cuidados terci&#225;rios de oito prov&#237;ncias diferentes da Turquia&#46; Foram avaliados retrospectivamente os pacientes acompanhados entre os anos de 2012 a 2022 com diagn&#243;stico de PG de acordo com os crit&#233;rios diagn&#243;sticos sugeridos por Su et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> no qual dois crit&#233;rios maiores &#40;&#250;lceras necrosantes dolorosas de r&#225;pida progress&#227;o com bordas irregulares vermelho&#8208;viol&#225;ceas elevadas e exclus&#227;o de outras causas de ulcera&#231;&#227;o cut&#226;nea&#41; e dois crit&#233;rios menores &#40;desenvolvimento de &#250;lcera no local de trauma menor sugerindo presen&#231;a de patergia ou achados cl&#237;nicos de cicatrizes cribriformes&#44; presen&#231;a de doen&#231;a sist&#234;mica associada ao PG&#44; achado histopatol&#243;gico de infiltra&#231;&#227;o est&#233;ril de neutr&#243;filos na derme&#44; resposta r&#225;pida &#224; terapia sist&#234;mica com esteroides&#41; deveriam ser atendidos&#46; Foram compilados dados de todos os pacientes com PG &#62;<span class="elsevierStyleHsp" style=""></span>18 anos dos centros de estudo&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A aprova&#231;&#227;o do Comit&#234; de &#201;tica n&#176; E1&#8208;22&#8208;2782 foi obtida do Ankara Bilkent City Hospital antes do estudo &#40;17&#46;08&#46;2022&#41;&#46; O presente estudo foi conduzido de acordo com os princ&#237;pios &#233;ticos da Declara&#231;&#227;o de Helsinque&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Para todos os tratamentos&#44; a cicatriza&#231;&#227;o de feridas &#8805; 75&#37; como par&#226;metro de desfecho foi avaliada como &#8220;boa resposta&#8221;&#46; Benef&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>75&#37; foi avaliado como &#8220;resposta deficiente a moderada&#8221; no presente estudo&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">An&#225;lise estat&#237;stica</span><p id="par0035" class="elsevierStylePara elsevierViewall">Os dados foram analisados utilizando SPSS&#47;IBM para Windows 23&#46;0 &#40;Chicago&#44; IL&#44; EUA&#41;&#46; Estat&#237;sticas descritivas como n&#250;mero e porcentagem para vari&#225;veis categ&#243;ricas e m&#233;dia&#44; mediana&#44; desvio padr&#227;o e intervalo interquartil &#40;IIQ&#41; para vari&#225;veis num&#233;ricas foram utilizadas para descrever a amostra&#46; O teste de signific&#226;ncia de qui&#8208;quadrado ou teste exato de Fisher foi utilizado para comparar vari&#225;veis categ&#243;ricas&#44; e o teste <span class="elsevierStyleItalic">t</span> de Student ou teste U de Mann&#8208;Whitney foi utilizado para comparar vari&#225;veis num&#233;ricas&#46; Os testes de correla&#231;&#227;o de Pearson e Spearman foram utilizados para avaliar a correla&#231;&#227;o entre duas vari&#225;veis num&#233;ricas&#46; Vari&#225;veis com valores de p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;2 foram avaliadas posteriormente com an&#225;lise de regress&#227;o log&#237;stica multivariada para identificar preditores independentes de resposta ao tratamento&#46; O ajuste do modelo foi avaliado pelo teste de Hosmer&#8208;Lemeshow&#46; O n&#237;vel de signific&#226;ncia estat&#237;stica foi determinado como p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 para todas as an&#225;lises&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Durante a an&#225;lise explorat&#243;ria&#44; verificou&#8208;se que pacientes com PG positivo para patergia e pacientes com PG com idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30 anos apresentavam caracter&#237;sticas cl&#237;nicas distintas e respostas ao tratamento significantes&#46; A escolha do ponto de corte de idade de 30 anos foi baseada tanto em dados bibliogr&#225;ficos &#40;a idade definida como o ponto de corte te&#243;rico entre a idade adulta emergente e a idade adulta estabelecida&#41;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">11&#44;12</span></a> quanto em evid&#234;ncias &#40;melhor potencial na previs&#227;o de m&#250;ltiplas doen&#231;as&#44; <span class="elsevierStyleItalic">endpoints</span> espec&#237;ficos de pacientes e desfechos utilizando considera&#231;&#245;es de infer&#234;ncia estat&#237;stica&#41;&#46; Optou&#8208;se por denominar o PG que se inicia antes dos 30 anos como PG de in&#237;cio precoce e &#8805; 30 anos como PG de in&#237;cio tardio no presente estudo&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Resultados</span><p id="par0045" class="elsevierStylePara elsevierViewall">O presente estudo incluiu 143 &#40;59&#44;8&#37;&#41; mulheres e 96 &#40;40&#44;2&#37;&#41; homens&#44; totalizando 239 pacientes&#46; A idade m&#233;dia dos pacientes foi de 54&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;4 anos&#46; A m&#233;dia de idade de in&#237;cio da doen&#231;a foi de 48&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;1 anos&#46; A dura&#231;&#227;o da doen&#231;a foi determinada como valor mediano de 24 meses &#40;IQR 6&#8208;84&#59; m&#237;n&#8208;m&#225;x&#58; 1&#8208;366&#41;&#46; Os dados demogr&#225;ficos dos pacientes e informa&#231;&#245;es de hospitaliza&#231;&#227;o s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; As caracter&#237;sticas das les&#245;es observadas nos pacientes s&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46; O n&#250;mero de pacientes com PG do tipo ulcerativo foi de 203 &#40;85&#37;&#41;&#44; representando o subtipo mais frequente&#46; Os subtipos de PG observados nos pacientes do presente estudo s&#227;o mostrados na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Comorbidades associadas ao PG</span><p id="par0050" class="elsevierStylePara elsevierViewall">O n&#250;mero de pacientes com pelo menos uma comorbidade associada ao PG foi 123 &#40;51&#44;5&#37;&#41;&#46; A idade de in&#237;cio da doen&#231;a foi mais precoce em pacientes com comorbidade relacionada ao PG em compara&#231;&#227;o com aqueles sem comorbidade &#40;45&#44;9 <span class="elsevierStyleItalic">vs</span>&#46; 50&#44;7 anos&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;048&#41;&#46; Artrite inflamat&#243;ria foi observada em 45 &#40;18&#44;8&#37;&#41; pacientes&#46; DII foi encontrada em 38 &#40;15&#44;9&#37;&#41; pacientes&#46; A HS estava presente em 17 &#40;7&#44;1&#37;&#41; pacientes&#46; A frequ&#234;ncia de doen&#231;a hematol&#243;gica foi de 6&#44;7&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41;&#46; As doen&#231;as hematol&#243;gicas observadas nos pacientes foram MGUS &#40;gamopatia monoclonal de significado indeterminado&#41;&#44; s&#237;ndrome mielodispl&#225;sica&#44; linfoma e leucemia&#46; Neoplasia maligna s&#243;lida estava presente em 14 &#40;5&#44;9&#37;&#41; pacientes&#46; S&#237;ndromes autoinflamat&#243;rias foram encontradas em nove &#40;3&#44;8&#37;&#41; pacientes &#40;PAPA&#44; PASH&#44; PAPASH&#41;&#46; Em pacientes com doen&#231;a autoinflamat&#243;ria&#44; as frequ&#234;ncias do g&#234;nero masculino&#44; hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; envolvimento de m&#250;ltiplas regi&#245;es e envolvimento de membros superiores foram maiores&#44; bem como a presen&#231;a de di&#226;metro maior na les&#227;o e maior n&#250;mero de hospitaliza&#231;&#245;es em compara&#231;&#227;o com aqueles sem doen&#231;a autoinflamat&#243;ria &#40;valores de p respectivamente 0&#44;019&#44; &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#44; &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#44; 0&#44;004&#44; 0&#44;006 e 0&#44;025&#41;&#46; Al&#233;m disso&#44; esses pacientes eram mais jovens e a idade de in&#237;cio da doen&#231;a era menor &#40;ambos p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; As comorbidades associadas ao PG s&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Patergia foi detectada em 55 &#40;23&#37;&#41; pacientes e foi negativa em 140 &#40;58&#44;6&#37;&#41;&#46; Em 44 &#40;18&#44;4&#37;&#41; pacientes&#44; o estado de patergia n&#227;o foi relatado&#46; Dor estava presente em 218 &#40;91&#44;2&#37;&#41; pacientes&#46; Os achados laboratoriais e histopatol&#243;gicos dos pacientes s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Tratamentos recebidos pelos pacientes</span><p id="par0060" class="elsevierStylePara elsevierViewall">Todos os pacientes tiveram as les&#245;es cuidadas&#46; Os tratamentos t&#243;picos mais utilizados foram esteroides &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>163&#59; 68&#44;2&#37;&#41;&#44; curativos sint&#233;ticos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#59; 30&#44;5&#37;&#41; e tacrolimus &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#59; 16&#44;7&#37;&#41;&#46; Como a maioria dos pacientes que receberam tratamento t&#243;pico tamb&#233;m recebeu tratamento sist&#234;mico&#44; as respostas aos tratamentos t&#243;picos n&#227;o puderam ser avaliadas no presente estudo&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">O tempo m&#233;dio entre o diagn&#243;stico e o in&#237;cio do tratamento sist&#234;mico foi de um m&#234;s &#40;IIQ 0&#44;5&#8208;3&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Tratamentos sist&#234;micos</span><p id="par0070" class="elsevierStylePara elsevierViewall">Esteroides sist&#234;micos foram o tratamento para 181 &#40;75&#44;7&#37;&#41; pacientes&#46; Desses&#44; 92 &#40;50&#44;8&#37;&#41; usaram esteroide sist&#234;mico como agente sist&#234;mico &#250;nico&#44; enquanto 89 &#40;49&#44;2&#37;&#41; usaram pelo menos um agente imunossupressor al&#233;m dos esteroides&#46; As caracter&#237;sticas desses dois grupos s&#227;o comparadas na <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">A dose m&#233;dia de esteroides foi de 48<span class="elsevierStyleHsp" style=""></span>mg &#40;IIQ 40&#8208;60&#41; de equivalente de metilprednisolona&#46; A dura&#231;&#227;o m&#233;dia do tratamento foi de 60 dias &#40;IIQ 30&#8208;100&#41;&#46; N&#227;o foi encontrada correla&#231;&#227;o entre a dose de esteroide e o benef&#237;cio do tratamento &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;71&#41;&#46; Boa resposta ao tratamento foi obtida em 46&#44;4&#37; dos pacientes&#46; O intervalo de tempo entre o diagn&#243;stico e o in&#237;cio do tratamento sist&#234;mico correlacionou&#8208;se inversamente com o benef&#237;cio do tratamento &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#59; r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#44;21&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">A an&#225;lise univariada das caracter&#237;sticas dos pacientes que responderam bem ao tratamento sist&#234;mico com esteroides &#233; mostrada na <a class="elsevierStyleCrossRef" href="#tbl0025">tabela 5</a>&#46; Uma an&#225;lise de regress&#227;o log&#237;stica multivariada adicional foi realizada &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">tabela 6</a>&#41;&#46; Aus&#234;ncia de envolvimento de membros superiores &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;041&#41;&#44; presen&#231;a de les&#227;o &#250;nica &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;019&#41;&#44; idade de in&#237;cio da doen&#231;a &#8805; 30 &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; aus&#234;ncia de leucocitose &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;012&#41;&#44; cultura negativa de les&#227;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; e patergia negativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41; foram determinados como os fatores independentes que influenciam as respostas ao tratamento sist&#234;mico com esteroides na an&#225;lise multivariada&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Oitenta e cinco &#40;35&#44;6&#37;&#41; pacientes usaram ciclosporina&#46; A mediana da dose de ciclosporina foi de 300<span class="elsevierStyleHsp" style=""></span>mg&#47;dia &#40;IIQ 237&#44;5&#8208;300&#41;&#46; A dura&#231;&#227;o m&#233;dia do tratamento foi de 100 dias &#40;60&#8208;200&#41;&#46; Recupera&#231;&#227;o completa foi observada em 19 &#40;22&#44;4&#37;&#41; pacientes&#46; N&#227;o foi observada correla&#231;&#227;o entre a dose de ciclosporina e o benef&#237;cio do tratamento &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;61&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Dez pacientes receberam tratamento com imunoglobulina intravenosa &#40;Ig IV&#41;&#44; e tr&#234;s desses pacientes obtiveram boa resposta&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Os tratamentos sist&#234;micos convencionais e Ig IV recebidos pelos pacientes e o benef&#237;cio relativo ao tratamento s&#227;o mostrados na <a class="elsevierStyleCrossRef" href="#tbl0035">tabela 7</a>&#46; Como alguns dos pacientes usaram mais de um tratamento sist&#234;mico convencional ou Ig IV simultaneamente&#44; n&#227;o foi poss&#237;vel fazer uma compara&#231;&#227;o direta em termos de efic&#225;cia entre esses tratamentos&#46;</p><elsevierMultimedia ident="tbl0035"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Tratamentos com biol&#243;gicos</span><p id="par0100" class="elsevierStylePara elsevierViewall">Agentes biol&#243;gicos foram utilizados em 44 &#40;18&#44;4&#37;&#41; pacientes&#46; O uso de agentes biol&#243;gicos foi mais comum em homens do que em mulheres &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41;&#44; em pacientes com hist&#243;rico familiar de doen&#231;as autoinflamat&#243;rias &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#41; e naqueles com envolvimento multirregional &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; envolvimento de cabe&#231;a e pesco&#231;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;019&#41;&#44; les&#245;es m&#250;ltiplas &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;024&#41;&#44; comorbidades &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41;&#44; cultura positiva de les&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;011&#41;&#44; patergia positiva &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#44; DII &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; HS &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;012&#41; e doen&#231;as autoinflamat&#243;rias &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Os pacientes em uso de tratamentos biol&#243;gicos eram mais jovens &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#44; tinham idade de in&#237;cio mais precoce &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; apresentavam mais les&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#44; mais hospitaliza&#231;&#245;es &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e maior tempo de hospitaliza&#231;&#227;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; em compara&#231;&#227;o com aqueles que n&#227;o utilizaram tratamentos biol&#243;gicos&#46; A dura&#231;&#227;o mediana entre o tratamento convencional e o tratamento biol&#243;gico foi de 24 meses &#40;IIQ 12&#8208;60&#41;&#46; Os agentes biol&#243;gicos recebidos pelos pacientes e os dados da resposta obtida s&#227;o mostrados na <a class="elsevierStyleCrossRef" href="#tbl0040">tabela 8</a>&#46;</p><elsevierMultimedia ident="tbl0040"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Al&#233;m disso&#44; foram analisados grupos com patergia positiva&#47;negativa e pacientes com PG com idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30&#47;idade de in&#237;cio &#8805; 30&#44; que foram chamados de PG de in&#237;cio precoce e tardio no presente estudo&#46; As caracter&#237;sticas dos pacientes com patergia positiva e negativa s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#tbl0045">tabela 9</a>&#46; As caracter&#237;sticas dos pacientes com PG de in&#237;cio precoce s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#tbl0050">tabela 10</a>&#46;</p><elsevierMultimedia ident="tbl0045"></elsevierMultimedia><elsevierMultimedia ident="tbl0050"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discuss&#227;o</span><p id="par0110" class="elsevierStylePara elsevierViewall">Ao examinar as comorbidades associadas ao PG&#44; verificou&#8208;se que 51&#44;5&#37; dos pacientes apresentavam pelo menos uma comorbidade&#46; As comorbidades mais comuns nos pacientes foram artrite inflamat&#243;ria&#44; DII&#44; HS&#44; dist&#250;rbios hematol&#243;gicos e neoplasias malignas s&#243;lidas&#44; respectivamente&#46; Da mesma maneira&#44; em um estudo multic&#234;ntrico realizado por Ashchyan et al&#46;&#44; foram examinados dados de 356 pacientes com PG e foi determinado que 66&#44;9&#37; dos pacientes tinham comorbidades associadas&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> DII foi encontrada em 41&#37;&#44; artrite inflamat&#243;ria em 20&#44;5&#37;&#44; neoplasias malignas de &#243;rg&#227;os s&#243;lidos em 6&#44;5&#37;&#44; neoplasias malignas hematol&#243;gicas em 5&#44;9&#37;&#44; outros dist&#250;rbios hematol&#243;gicos em 4&#44;8&#37; e HS em 6&#44;2&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> No estudo de Langan et al&#46;&#44; doen&#231;as associadas ao PG foram detectadas em 33&#37; dos pacientes&#46; A doen&#231;a associada mais comum foi a DII&#44; observada em 20&#44;2&#37; dos casos&#44; seguida por artrite reumatoide &#40;11&#44;8&#37;&#41; e dist&#250;rbios hematol&#243;gicos &#40;3&#44;9&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a> S&#237;ndromes autoinflamat&#243;rias &#40;PAPA&#44; PASH&#44; PAPASH&#41; foram encontradas em 3&#44;8&#37; dos nossos pacientes&#46; Avaliando as caracter&#237;sticas desses pacientes&#44; notou&#8208;se que geralmente eram jovens e masculinos&#44; tinham idade de in&#237;cio da doen&#231;a mais precoce e tinham hist&#243;rico familiar de doen&#231;as autoinflamat&#243;rias&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">O achado laboratorial mais comum em nossos pacientes foi a eleva&#231;&#227;o dos n&#237;veis de prote&#237;na C&#8208;reativa &#40;PCR&#41;&#44; observada em 69&#44;7&#37;&#46; Anemia estava presente em 51&#44;9&#37; dos pacientes&#46; Em um estudo&#44; n&#237;veis elevados de PCR foram encontrados em 56&#44;3&#37; dos pacientes com PG&#59;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a> em outro estudo&#44; anemia foi observada em 45&#44;6&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">16</span></a> A presen&#231;a de crescimento microbiano em culturas de les&#245;es em 46&#44;4&#37; dos pacientes do presente estudo sugere que as les&#245;es do PG s&#227;o propensas a infec&#231;&#245;es secund&#225;rias&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Patergia foi identificada em 23&#37; dos nossos pacientes&#44; enquanto n&#227;o havia informa&#231;&#227;o sobre patergia em 18&#44;4&#37;&#46; Semelhante ao presente estudo&#44; no estudo de Binus et al&#46;&#44; a patergia foi registrada em 31&#44;1&#37;&#59;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a> no estudo de Ashchyan et al&#46;&#44; a taxa foi de 28&#44;1&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">O subtipo de PG mais comum nos pacientes do presente estudo foi o ulcerativo&#44; respons&#225;vel por 85&#37; dos casos&#44; seguido por PG bolhoso &#40;4&#44;2&#37;&#41; e pustuloso &#40;3&#44;8&#37;&#41;&#46; No estudo de Schosler et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a> a distribui&#231;&#227;o dos subtipos de PG foi 85&#44;9&#37; ulcerativo&#44; 3&#44;1&#37; bolhoso&#44; 6&#44;3&#37; periestomal&#44; 3&#44;1&#37; vegetante e 1&#44;6&#37; pustuloso&#44; o que foi semelhante ao presente estudo&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Os pacientes do presente estudo que receberam tratamento sist&#234;mico foram geralmente tratados de acordo com um algoritmo terap&#234;utico&#46; Em geral&#44; os corticosteroides sist&#234;micos foram o tratamento inicial para os pacientes do presente estudo&#46; Ciclosporina&#44; azatioprina&#44; dapsona&#44; mofetil micofenolato e colchicina foram utilizados como agentes poupadores de esteroides ou como agentes de tratamento adjuvantes&#46; Ig IV e medicamentos biol&#243;gicos foram utilizados como tratamentos de terceira linha&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Em muitos estudos&#44; os esteroides sist&#234;micos s&#227;o os mais comumente utilizados como tratamento de primeira linha<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">15&#44;17&#44;18</span></a>&#44; assim como no presente estudo&#46; Entretanto&#44; &#233; necess&#225;rio tratamento imunossupressor adicional para a maioria dos pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a> Quando foram examinadas as principais caracter&#237;sticas do grupo para o qual os esteroides sist&#234;micos por si s&#243; n&#227;o foram suficientes e foi necess&#225;rio tratamento imunossupressor adicional&#44; observou&#8208;se que a frequ&#234;ncia de envolvimento de m&#250;ltiplas regi&#245;es&#44; m&#250;ltiplas les&#245;es&#44; presen&#231;a de DII&#44; doen&#231;as autoinflamat&#243;rias e patergia positiva eram maiores &#40;todos p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; nesse grupo&#46; Os resultados surpreendentes da an&#225;lise de regress&#227;o multivariada que revelaram caracter&#237;sticas dos pacientes que apresentaram boa resposta aos esteroides sist&#234;micos foram idade de in&#237;cio da doen&#231;a &#8805; 30 anos&#44; patergia negativa&#44; aus&#234;ncia de leucocitose e cultura negativa de les&#245;es&#46; No presente estudo&#44; resposta completa foi alcan&#231;ada em 28&#44;7&#37; dos pacientes que usaram esteroides sist&#234;micos&#44; com mediana de dose de 48<span class="elsevierStyleHsp" style=""></span>mg de equivalente de metilprednisolona e dura&#231;&#227;o mediana de 60 dias&#46; Em estudo multic&#234;ntrico&#44; Herberger et al&#46; avaliaram as respostas ao tratamento de 121 pacientes com PG&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a> O tratamento inicial em 99&#37; desses pacientes foi esteroides sist&#234;micos na dose m&#233;dia de 80<span class="elsevierStyleHsp" style=""></span>mg&#46; O tratamento m&#233;dio com esteroides sist&#234;micos durou 4&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6 meses&#46; A resposta inicial aos esteroides sist&#234;micos foi obtida em 88&#37;&#46; Foi relatado que os pacientes que receberam tratamento para PG receberam em m&#233;dia dois tratamentos sist&#234;micos diferentes&#44; e a import&#226;ncia dos regimes combinados de tratamento no PG foi enfatizada&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Nos pacientes do presente estudo&#44; outro agente de tratamento frequentemente utilizado foi a ciclosporina&#44; administrada em m&#233;dia por 100 dias e na dose de 300<span class="elsevierStyleHsp" style=""></span>mg&#46; A ciclosporina utilizada em 35&#44;6&#37; dos pacientes do presente estudo obteve taxa de resposta completa de 22&#44;4&#37;&#46; Em ensaio cl&#237;nico randomizado multic&#234;ntrico comparando esteroides sist&#234;micos e ciclosporina no tratamento de PG&#44; um grupo recebeu 0&#44;75<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;dia de prednisolona em monoterapia&#44; enquanto outro grupo recebeu 4<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;dia de ciclosporina&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a> No final da 6&#170; semana&#44; n&#227;o foi observada diferen&#231;a entre os dois grupos em rela&#231;&#227;o a taxa de cura&#44; resposta ao tratamento&#44; dor e dura&#231;&#227;o da recorr&#234;ncia&#46; No entanto&#44; no 6&#176; m&#234;s&#44; n&#227;o foi observada cura em aproximadamente metade dos pacientes em ambos os grupos&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Azatioprina foi utilizada em 12&#44;6&#37; dos pacientes do presente estudo&#46; Entre esses pacientes&#44; 16&#44;7&#37; tiveram cura completa&#46; A azatioprina pode ser usada como agente poupador de esteroides no PG refrat&#225;rio ou como alternativa aos tratamentos de primeira linha&#46; Tamb&#233;m pode ser boa op&#231;&#227;o no PG acompanhado de DII&#46; A azatioprina geralmente surge como op&#231;&#227;o de tratamento bem tolerada e eficaz&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> No presente estudo&#44; o medicamento tamb&#233;m foi geralmente utilizado em pacientes com DII&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Dapsona foi utilizada em 7&#44;9&#37; dos pacientes do presente estudo&#46; Os dados referentes ao uso de dapsona no PG s&#227;o baseados em relatos de casos e s&#233;ries de casos&#46; No estudo de Din et al&#46;&#44; foram avaliadas as respostas ao tratamento de 27 pacientes que receberam terapia com dapsona para PG&#44; com 16&#37; dos pacientes apresentando resposta completa e 81&#37; apresentando resposta parcial&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">21</span></a> No presente estudo&#44; obteve&#8208;se boa resposta em 52&#44;6&#37; dos pacientes&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Colchicina foi utilizada em 7&#44;1&#37; dos pacientes do presente estudo&#46; Poucos casos foram relatados quanto ao uso de colchicina no PG&#46; Kontochristopoulos et al&#46; relataram r&#225;pida regress&#227;o em dois pacientes com PG refrat&#225;rio tratados com monoterapia com colchicina em baixas doses&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a> Cura completa foi observada em 5&#44;9&#37; dos pacientes do presente estudo&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Nove de nossos pacientes foram tratados com metotrexato&#46; Entre eles&#44; 77&#44;7&#37; obtiveram resposta de cura abaixo de 50&#37;&#46; O metotrexato &#233; um imunomodulador&#44; e as informa&#231;&#245;es sobre seu uso no PG baseiam&#8208;se em relatos de casos&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Mofetil micofenolato foi administrado em seis pacientes do presente estudo&#44; com dose m&#233;dia de 1&#44;5<span class="elsevierStyleHsp" style=""></span>g&#47;dia&#46; Entretanto&#44; todos os pacientes tiveram resposta ao tratamento inferior a 50&#37;&#46; O mofetil micofenolato &#233; considerado agente poupador de esteroides de segunda linha em pacientes com PG&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">No presente estudo&#44; dez pacientes receberam tratamento com Ig IV&#46; Todos eles receberam um a tr&#234;s ciclos de tratamento na dose de 2<span class="elsevierStyleHsp" style=""></span>g&#47;kg&#47;4 semanas&#46; Resposta ao tratamento &#8805; 75&#37; foi alcan&#231;ada em 30&#37; desses pacientes&#46; No estudo de Haag et al&#46;&#44; os autores compilaram a efic&#225;cia do tratamento com Ig IV em casos refrat&#225;rios&#44; identificando cura completa em 23 de 45 pacientes e resposta parcial ou n&#227;o responsividade em 22 pacientes&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Agentes biol&#243;gicos foram utilizados em 18&#44;4&#37; dos pacientes no presente estudo&#46; Descrevendo as caracter&#237;sticas fundamentais do grupo que necessita de transi&#231;&#227;o dos tratamentos convencionais para a terapia com agentes biol&#243;gicos&#44; verifica&#8208;se que esses inclu&#237;am pacientes com in&#237;cio precoce da doen&#231;a&#44; pacientes jovens&#44; masculinos&#44; com doen&#231;as autoinflamat&#243;rias&#44; com DII&#44; pacientes apresentando HS e aqueles que apresentavam patergia positiva&#46; A mediana do tempo de transi&#231;&#227;o do tratamento convencional para o tratamento biol&#243;gico nos pacientes do presente estudo foi de 24 meses&#46; Infliximabe&#44; o agente biol&#243;gico mais utilizado&#44; foi considerado para 15&#44;1&#37; desses pacientes&#46; O infliximabe foi administrado aos pacientes na dose aprovada usada na psor&#237;ase&#46; A mediana de dura&#231;&#227;o do tratamento foi de 12 meses&#44; e boa resposta foi obtida em 63&#44;9&#37; dos pacientes&#46; Adalimumabe foi o segundo agente biol&#243;gico mais utilizado nesses pacientes &#40;7&#44;9&#37;&#41;&#44; administrado em tr&#234;s doses diferentes&#58; a dose aprovada utilizada na psor&#237;ase&#44; 40<span class="elsevierStyleHsp" style=""></span>mg&#47;semana e 80<span class="elsevierStyleHsp" style=""></span>mg&#47;semana&#46; A dura&#231;&#227;o m&#233;dia do tratamento foi de 14 meses&#44; e a taxa de pacientes que responderam com &#8805; 75&#37; foi de 5&#44;2&#37;&#46; Tr&#234;s pacientes usaram etanercepte&#46; Os pacientes utilizaram a dose aprovada durante m&#233;dia de oito meses&#44; mas a resposta ao tratamento n&#227;o excedeu 50&#37;&#46; Infliximabe &#233; o &#250;nico agente anti&#8208;TNF cuja efic&#225;cia foi demonstrada no PG cl&#225;ssico por meio de um estudo randomizado duplo&#8208;cego controlado&#46; No estudo randomizado controlado por placebo conduzido por Brooklyn et al&#46;&#44; resposta parcial foi alcan&#231;ada em 48&#37; e resposta completa em 21&#37; ao final de seis semanas&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a> Em um estudo de fase 3&#44; aberto e multic&#234;ntrico&#44; a efic&#225;cia e a seguran&#231;a do adalimumabe no PG refrat&#225;rio foram investigadas e cura completa foi registrada em 54&#44;5&#37; ap&#243;s 26 semanas de tratamento&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">26</span></a> Abdallah et al&#46; realizaram uma revis&#227;o semissistem&#225;tica sobre o uso de inibidores de TNF&#8208;&#945; no PG&#46; Nenhuma diferen&#231;a foi encontrada entre infliximabe&#44; adalimumabe e etanercepte em termos de taxas de resposta parcial e completa&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">27</span></a> Em especial&#44; infliximabe e adalimumabe&#44; dois antagonistas do TNF&#8208;&#945; parecem ser boa op&#231;&#227;o para casos resistentes ou para evitar os efeitos colaterais em longo prazo dos esteroides sist&#234;micos ou da ciclosporina&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">27</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">No presente estudo&#44; houve quatro pacientes em uso de ustequinumabe&#44; com taxa de resposta de 25&#37;&#8208;75&#37;&#46; Em uma revis&#227;o semissistem&#225;tica&#44; a taxa de resposta completa foi de 71&#37; em pacientes tratados com ustequinumabe&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">Os inibidores de IL&#8208;1 utilizados no tratamento do PG s&#227;o anakinra e canaquinumabe&#46; Tr&#234;s pacientes com doen&#231;a autoinflamat&#243;ria utilizaram anakinra no presente estudo&#46; Apenas um desses pacientes obteve boa resposta&#46; Um paciente utilizou canaquinumabe no presente estudo&#44; o qual continuou o tratamento por 36 meses e respondeu ao tratamento com taxa de cura &#8805; 75&#37;&#46; Na revis&#227;o semissistem&#225;tica de Abdallah et al&#46;&#44; resposta completa foi alcan&#231;ada em 57&#37; dos pacientes &#40;IC 95&#37; de 45&#37;&#8208;68&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Tr&#234;s pacientes utilizaram secuquinumabe no presente estudo&#46; Enquanto dois pacientes responderam com taxa de cura de 25&#37; a 50&#37;&#44; o outro paciente respondeu com taxa de cura &#8805; 75&#37;&#46; Um paciente recebeu tratamento com risanquizumabe&#44; e obteve resposta de cura de 75&#37; ou mais ao final de quatro meses de tratamento&#46; Um paciente recebeu tratamento com ixequizumabe&#44; interrompido ao final de seis meses porque n&#227;o foi poss&#237;vel obter resposta adequada ao tratamento&#46; H&#225; relatos de casos indicando que secuquinumabe&#44; risanquizumabe e ixequizumabe s&#227;o eficazes no PG resistente&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">29&#8211;31</span></a>O presente estudo revelou dados convincentes sobre dois grupos espec&#237;ficos de pacientes&#46; Naqueles com patergia positiva&#44; havia maior taxa de hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; presen&#231;a de envolvimento de m&#250;ltiplas regi&#245;es&#44; maior n&#250;mero total e dura&#231;&#227;o total de hospitaliza&#231;&#245;es e maior taxa de presen&#231;a de doen&#231;a autoinflamat&#243;ria&#46; O grupo com patergia positiva tamb&#233;m diferiu significantemente do grupo com patergia negativa em rela&#231;&#227;o ao tratamento e respostas ao tratamento&#46; No grupo com patergia positiva&#44; a taxa de resposta aos esteroides sist&#234;micos foi significantemente menor&#44; a taxa de uso de imunossupressores sist&#234;micos adjuvantes foi alta e a taxa de uso de agentes biol&#243;gicos foi alta&#46; Outro grupo espec&#237;fico foi o PG de in&#237;cio precoce &#40;idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30&#41;&#44; no qual a hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; o envolvimento da cabe&#231;a e pesco&#231;o&#44; a presen&#231;a de DII e de doen&#231;a autoinflamat&#243;ria foram mais frequentes&#46; Al&#233;m disso&#44; no PG de in&#237;cio precoce&#44; a taxa de pacientes que responderam aos esteroides sist&#234;micos foi baixa&#44; e as taxas de uso de tratamentos imunossupressores adjuvantes e biol&#243;gicos foram significantemente altas&#46; Acredita&#8208;se ser necess&#225;rio considerar que pacientes com patergia positiva e PG de in&#237;cio precoce sejam mais resistentes ao tratamento&#44; necessitando de tratamentos mais complexos&#46; De fato&#44; &#233; crucial investigar a exist&#234;ncia de doen&#231;as autoinflamat&#243;rias coexistentes no momento do diagn&#243;stico em pacientes com patergia positiva e PG de in&#237;cio precoce&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Uma limita&#231;&#227;o do presente estudo &#233; a aus&#234;ncia de crit&#233;rios diagn&#243;sticos padr&#227;o para PG&#44; o que torna incerto se o diagn&#243;stico foi realizado com precis&#227;o em todos os casos&#46; Al&#233;m disso&#44; acredita&#8208;se que alguns dados possam ter sido perdidos&#44; pois o presente estudo abrange pacientes dos &#250;ltimos dez anos&#46; Em virtude da falta de qualquer escala para pontuar a gravidade da doen&#231;a&#44; as taxas de resposta foram baseadas na avalia&#231;&#227;o dos m&#233;dicos nos prontu&#225;rios dos pacientes&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclus&#245;es</span><p id="par0200" class="elsevierStylePara elsevierViewall">O PG &#233; doen&#231;a cr&#244;nica rara acompanhada de muitas comorbidades&#46; Embora os esteroides sist&#234;micos tenham sido suficientes em cerca de metade dos pacientes avaliados no presente estudo&#44; foram necess&#225;rios tratamentos imunossupressores adicionais na outra metade&#46; Presen&#231;a de m&#250;ltiplas les&#245;es&#44; envolvimento de m&#250;ltiplas regi&#245;es&#44; doen&#231;a autoinflamat&#243;ria e DII foram caracter&#237;sticas comuns dos pacientes que necessitaram de tratamento adicional com imunossupressores e biol&#243;gicos&#46; Al&#233;m disso&#44; acredita&#8208;se que a presen&#231;a de patergia positiva e PG de in&#237;cio precoce possam fornecer aos m&#233;dicos informa&#231;&#245;es sobre o curso e o progn&#243;stico da doen&#231;a&#44; e a mudan&#231;a para tratamentos avan&#231;ados mais precocemente&#44; nesses casos&#44; pode ser ben&#233;fica&#46; Acredita&#8208;se que os dados compilados no presente estudo multic&#234;ntrico&#44; com abrang&#234;ncia de dez anos em 12 hospitais terci&#225;rios na Turquia&#44; contribuir&#227;o para o conhecimento sobre essa doen&#231;a&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Suporte financeiro</span><p id="par0205" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Contribui&#231;&#227;o dos autores</span><p id="par0210" class="elsevierStylePara elsevierViewall">Funda Erduran&#58; Concep&#231;&#227;o e planejamento do estudo&#44; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o de dados&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#44; revis&#227;o cr&#237;tica do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Esra Ad&#305;&#351;en&#58; Concep&#231;&#227;o e planejamento do estudo&#44; obten&#231;&#227;o de dados&#44; supervis&#227;o&#44; revis&#227;o cr&#237;tica e edi&#231;&#227;o do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Y&#305;ld&#305;z Hayran&#58; Obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">G&#252;ne&#351; G&#252;r Aksoy&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Erkan Alpsoy&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Leyla Baykal Sel&#231;uk&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Sibel Do&#287;an G&#252;nayd&#305;n&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">Ay&#231;a Cordan Yaz&#305;c&#305;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">Ay&#351;e &#214;ktem&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Malik G&#252;ng&#246;r&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">Elif Afacan&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Deniz Devrim Ku&#351;&#231;u&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">Leyla Elmas&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">K&#252;bra Aydo&#287;an&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Dilek Bayramg&#252;rler&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0285" class="elsevierStylePara elsevierViewall">Evren Odyakmaz Demirsoy&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Melih Akyol&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Rukiye G&#252;ner&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">Hilal Kaya Erdo&#287;an&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">Ersoy Acer&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0310" class="elsevierStylePara elsevierViewall">Tulin Ergun&#44; Sava&#351; Yayl&#305;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0315" class="elsevierStylePara elsevierViewall">Ferhan Bulut&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0320" class="elsevierStylePara elsevierViewall">Esra Sara&#231;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Ak&#305;n Akta&#351;&#58; Obten&#231;&#227;o de dados&#44; edi&#231;&#227;o&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflito de interesses</span><p id="par0330" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pioderma gangrenoso &#40;PG&#41; &#233; doen&#231;a cr&#244;nica caracterizada por &#250;lceras cut&#226;neas recalcitrantes&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar as caracter&#237;sticas demogr&#225;ficas e cl&#237;nicas&#44; os tratamentos e fatores que afetam as respostas ao tratamento de pacientes com PG&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Foi realizado estudo multic&#234;ntrico em 12 centros de aten&#231;&#227;o terci&#225;ria&#46; Foram analisados retrospectivamente os dados dos pacientes acompanhados com diagn&#243;stico de PG entre os anos de 2012 a 2022&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos um total de 239 pacientes&#44; dos quais 143 eram do g&#234;nero feminino e 96 do g&#234;nero masculino&#44; com m&#233;dia de idade de 54&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;4 anos&#46; O tratamento mais comum foram esteroides sist&#234;micos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>181&#59; 75&#44;7&#37;&#41;&#46; Entre esses pacientes&#44; 50&#44;8&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>92&#41; utilizaram esteroides sist&#234;micos como &#250;nica terap&#234;utica&#44; enquanto 49&#44;2&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>89&#41; usaram pelo menos um agente imunossupressor adjuvante&#46; Os fatores independentes determinados na an&#225;lise de regress&#227;o que influenciaram positivamente a resposta aos esteroides sist&#234;micos foram idade de in&#237;cio da doen&#231;a &#8805; 30 anos&#44; patergia negativa&#44; aus&#234;ncia de leucocitose&#44; cultura de les&#227;o negativa&#44; presen&#231;a de les&#227;o &#250;nica e aus&#234;ncia de envolvimento dos membros superiores&#46; Agentes biol&#243;gicos foram utilizados em 18&#44;4&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#41; dos pacientes do presente estudo&#46; Tamb&#233;m foram analisados PG positivo para patergia e PG de in&#237;cio precoce &#40;idade de in&#237;cio &#60;<span class="elsevierStyleHsp" style=""></span>30&#41; separadamente em virtude de suas caracter&#237;sticas cl&#237;nicas distintas que foram reveladas durante a an&#225;lise estat&#237;stica&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Natureza retrospectiva do presente estudo&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A an&#225;lise dos fatores que influenciam as respostas ao tratamento &#233; abordada no presente estudo&#46; Al&#233;m disso&#44; concluiu&#8208;se que a investiga&#231;&#227;o de doen&#231;as autoinflamat&#243;rias concomitantes com PG positivo para patergia e PG de in&#237;cio precoce &#233; necess&#225;ria&#44; e os pacientes desses dois grupos s&#227;o mais resistentes ao tratamento&#44; necessitando de tratamentos mais complexos&#46;</p></span>"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">DP&#44; desvio&#8208;padr&#227;o&#59; IIQ&#44; intervalo interquartil&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">239</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Feminino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">143 &#40;59&#44;8&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;40&#44;2&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#233;dia de idade<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP &#40;anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;4</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade de in&#237;cio<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP &#40;anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;1</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dura&#231;&#227;o da doen&#231;a &#40;meses&#41; &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;6&#8208;84&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Taxa de hospitaliza&#231;&#227;o&#44; n &#40;&#37;&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">187 &#40;78&#44;2&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de hospitaliza&#231;&#245;es</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uma vez&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;37&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duas vezes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;19&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tr&#234;s vezes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;9&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805; Quatro vezes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tempo total de hospitaliza&#231;&#227;o &#40;dias&#41;&#8208; Mediana &#40;IIQ&#41; &#40;m&#237;n&#8208;m&#225;x&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;12&#8208;39&#41; &#40;m&#237;n&#8208;m&#225;x&#58; 1&#8208;113&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Menor per&#237;odo de hospitaliza&#231;&#227;o &#40;dias&#41;&#8208; Mediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;6&#8208;14&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maior per&#237;odo de hospitaliza&#231;&#227;o &#40;dias&#41;&#8208; Mediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;5 &#40;10&#8208;23&#41;</td></tr></tbody></table>
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Localiza&#231;&#227;o das les&#245;es</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Extremidades inferiores&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">189 &#40;79&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Extremidades superiores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Corpo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cabe&#231;a&#8208;pesco&#231;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;3&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Outras &#40;mucosa oral&#44; regi&#227;o genital&#44; regi&#227;o gl&#250;tea&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Maior tamanho de les&#227;o &#40;cm&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#8208;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104 &#40;43&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&#8208;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>10&#8208;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">29 &#40;12&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">90 &#40;37&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">108 &#40;45&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&#8208;10 les&#245;es&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artrite inflamat&#243;ria &#40;artrite reumatoide&#44; artrite psori&#225;tica&#44; artrite gotosa&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;as hematol&#243;gicas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hidradenite supurativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neoplasia maligna s&#243;lida&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;5&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;as autoinflamat&#243;rias &#40;PAPA&#44; PASH&#44; PAPASH&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Outras &#40;doen&#231;a de Beh&#231;et&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">51&#44;5<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">124 &#40;51&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neutrofilia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#237;vel elevado de PCR<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">166 &#40;69&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#237;vel elevado de eritrossedimenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dist&#250;rbio eletrol&#237;tico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Compat&#237;vel com PG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de dor</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Uma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&#250;ltiplas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;009</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;10&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">33 &#40;35&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46 &#40;51&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">59 &#40;64&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43 &#40;48&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Doen&#231;a autoinflamat&#243;ria</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">91 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Doen&#231;a inflamat&#243;ria intestinal</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;040</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">11 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">21 &#40;23&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">81 &#40;88&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">68 &#40;76&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Maior tamanho de les&#227;o</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;008</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49 &#40;53&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">30 &#40;33&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43 &#40;46&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">59 &#40;66&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Idade&#44; m&#233;dia &#40;DP&#41; &#40;anos&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">56&#44;5 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">48&#44;7 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade de in&#237;cio da doen&#231;a &#40;DP&#41; &#40;anos&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 30&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dura&#231;&#227;o da doen&#231;a &#40;meses&#41;&#44; mediana &#40;IIQ&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a> Boa resposta&#44; n&#160;&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a> Resposta deficiente a moderada&#44; n&#160;&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&#250;ltiplas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;8&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cultura de les&#245;es</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;002</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">72 &#40;85&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;001</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">53 &#40;54&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">58 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">44 &#40;45&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Doen&#231;a autoinflamat&#243;ria</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;007</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;91&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Artrite inflamat&#243;ria</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;012</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">23 &#40;23&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">76 &#40;90&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">74 &#40;76&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tamanho da maior les&#227;o</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">0&#44;002</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47 &#40;56&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 5 cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">65 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade de in&#237;cio da doen&#231;a &#40;anos&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;27&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;90&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70 &#40;72&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dura&#231;&#227;o da doen&#231;a&#44; meses</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;91&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;69&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 100&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;30&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RR</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IC 95&#37; para RR</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Inferior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de envolvimento dos membros superiores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;041&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de les&#227;o &#250;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade de in&#237;cio da doen&#231;a &#8805; 30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de leucocitose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cultura negativa de les&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patergia negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise de regress&#227;o log&#237;stica multivariada das caracter&#237;sticas dos pacientes com boa resposta aos esteroides sist&#234;micos</p>"
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      6 => array:8 [
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        "etiqueta" => "Tabela 7"
        "tipo" => "MULTIMEDIATABLA"
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            "identificador" => "at7"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">IIQ&#44; intervalo interquartil&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Esteroides sist&#234;micos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ciclosporina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Azatioprina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dapsona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Colchicina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ig IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Micofenolato Mofetil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Talidomida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de pacientes usando&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">181 &#40;75&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;35&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dose&#44; mediana &#40;IIQ</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">a</span></span></a><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48 mg&#47;dia &#40;40&#8208;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">300 mg&#47;dia &#40;237&#44;5&#8208;300&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150 mg&#47;dia &#40;100&#8208;150&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150 mg&#47;dia &#40;100&#8208;150&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5 mg&#47;dia &#40;1&#8208;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 g&#47;kg&#47; 4 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 mg&#47;semana &#40;13&#44;75&#8208;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5 g&#47;dia &#40;1&#44;38&#8208;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">100 mg&#47;dia &#40;100&#8208;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#8208;3 meses&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>25&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;23&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>25&#37;&#8208;50&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;21&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;52&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>50&#37;&#8208;&#60;<span class="elsevierStyleHsp" style=""></span>75&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">39 &#40;21&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Recupera&#231;&#227;o completa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero de pacientes recebendo tratamento&#44; n&#160;&#40;&#37;&#41;</th><th class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dura&#231;&#227;o m&#233;dia do tratamento &#40;meses&#41; &#40;IIQ&#41;</th><th class="td" title="\n
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                  \t\t\t\t  " colspan="5" align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#8805; 75&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36 &#40;15&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">12 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">19 &#40;7&#44;9&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">R &#40;42&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;12&#8208;27&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">6 &#40;31&#44;6&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">4 &#40;21&#44;1&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">2 &#40;10&#44;5&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;5&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t">5 &#40;26&#44;3&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 mg&#47;semana &#40;47&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80 mg&#47;semana &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustequinumabe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Etanercepte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secuquinumabe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anakinra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100 mg&#47;dia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risanquizumabe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">300 mg&#47;4&#8208;semanas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;sticas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">68 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de hist&#243;ria familiar de doen&#231;a autoinflamat&#243;ria&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de envolvimento de m&#250;ltiplos locais&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero total de hospitaliza&#231;&#245;es&#44; mediana &#40;IIQ&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;1&#8208;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;1&#8208;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;043&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tempo total de interna&#231;&#227;o&#44; mediana &#40;IIQ&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27&#44;5 &#40;12&#8208;63&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">20 &#40;11&#44;5&#8208;34&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;046&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Presen&#231;a de doen&#231;a autoinflamat&#243;ria&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Aplica&#231;&#227;o de tratamento t&#243;pico isolado&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Esteroides sist&#234;micos &#43; agentes imunossupressores adicionais&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de pacientes com boa resposta aos esteroides sist&#234;micos &#40;taxa de resposta &#8805; 75&#37;&#41;&#44; n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Esteroides sist&#234;micos &#43; agentes imunossupressores adicionais&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de pacientes com boa resposta aos ester&#243;ides sist&#234;micos &#40;taxa de resposta &#8805; 75&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Uso de agente biol&#243;gico&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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Article information
ISSN: 26662752
Original language: Portuguese
DOI:10.1016/j.abdp.2024.05.001
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