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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">O carcinoma basocelular &#40;CBC&#41; &#233; o c&#226;ncer de pele mais comum em todo o mundo&#44; com incid&#234;ncia t&#227;o alta que est&#225; fora das estat&#237;sticas globais de c&#226;ncer&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> Nas &#250;ltimas d&#233;cadas&#44; sua incid&#234;ncia aumentou e&#44; apesar de sua baixa letalidade&#44; pode ter comportamento local agressivo e representa grande &#244;nus para os sistemas de sa&#250;de globais&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A dermatoscopia &#233; ferramenta diagn&#243;stica que se mostrou muito &#250;til no CBC&#44; com sensibilidade de 91&#37; e especificidade de 95&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;5</span></a> Possibilita assim a detec&#231;&#227;o precoce e o planejamento do tratamento&#59; ainda assim&#44; a confirma&#231;&#227;o histopatol&#243;gica continua sendo necess&#225;ria para seu diagn&#243;stico&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6&#8211;9</span></a> Atualmente&#44; CBCs menores s&#227;o encontrados com mais frequ&#234;ncia&#44; provavelmente em virtude da cultura de cuidados preventivos e dos avan&#231;os tecnol&#243;gicos&#46; CBCs pequenos foram definidos por alguns autores como aqueles com menos de 5<span class="elsevierStyleHsp" style=""></span>mm&#44; enquanto CBCs menores que 3<span class="elsevierStyleHsp" style=""></span>mm foram denominados de pequeno di&#226;metro &#40;CBCsPD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">10&#8211;15</span></a> Em rela&#231;&#227;o &#224; apresenta&#231;&#227;o cl&#237;nica&#44; CBCs pequenos s&#227;o mais prevalentes em homens mais jovens&#44; na regi&#227;o da face&#44; geralmente s&#227;o pigmentados e seu tipo histopatol&#243;gico mais comum &#233; o nodular&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> A detec&#231;&#227;o em est&#225;dios tumorais iniciais est&#225; relacionada a tratamento mais f&#225;cil&#44; com melhores resultados est&#233;ticos e menor impacto funcional&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> Atualmente&#44; a literatura &#233; clara quanto aos crit&#233;rios dermatosc&#243;picos cl&#225;ssicos e n&#227;o cl&#225;ssicos do CBC&#59; entretanto&#44; poucos estudos sobre dermatoscopia de CBCs pequenos foram realizados&#44; relatando que esses CBCs podem apresentar caracter&#237;sticas dermatosc&#243;picas cl&#225;ssicas e n&#227;o cl&#225;ssicas&#44; com pontos cinza&#8208;azulados e ninhos ovoides como estruturas principais&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">11&#44;12</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Os CBCsPD s&#227;o les&#245;es ainda mais incipientes&#44; que podem apresentar caracter&#237;sticas diferentes em virtude da fase inicial de crescimento tumoral&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#8211;18</span></a> A dermatoscopia nesses tumores n&#227;o foi amplamente estudada&#59; portanto&#44; h&#225; escassez de literatura m&#233;dica relatando e comparando suas caracter&#237;sticas dermatosc&#243;picas com as de CBCs maiores&#46; O objetivo deste estudo foi descrever e comparar as caracter&#237;sticas dermatosc&#243;picas dos CBCs com di&#226;metro &#8804; 3<span class="elsevierStyleHsp" style=""></span>mm com as daqueles de 3 a 10<span class="elsevierStyleHsp" style=""></span>mm de di&#226;metro&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Materiais e m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Este foi um estudo transversal anal&#237;tico realizado entre janeiro de 2017 e dezembro de 2021 em Medell&#237;n&#44; Col&#244;mbia&#46; Os crit&#233;rios de inclus&#227;o compreenderam pacientes com diagn&#243;stico histopatol&#243;gico de CBC&#44; que apresentavam fotos dermatosc&#243;picas com aumento de 10<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>ou 20<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#46; Foram exclu&#237;dos casos de CBC recorrente e casos sem consentimento do paciente para an&#225;lise fotogr&#225;fica&#46; Os casos foram selecionados retrospectiva e prospectivamente em um centro de refer&#234;ncia em c&#226;ncer de pele&#46; Um banco de dados institucional com todos os CBCs diagnosticados foi examinado&#44; e os casos que atenderam aos crit&#233;rios de elegibilidade foram inclu&#237;dos&#46; Prospectivamente&#44; novos casos de CBC com confirma&#231;&#227;o histopatol&#243;gica foram examinados e&#44; se eleg&#237;veis&#44; inclu&#237;dos&#46; O tamanho do estudo foi determinado pelo n&#250;mero total de CBCs que atenderam aos crit&#233;rios de elegibilidade e foram diagnosticados durante o per&#237;odo mencionado&#46; O protocolo do estudo estava de acordo com as diretrizes &#233;ticas da Declara&#231;&#227;o de Helsinki&#46; A aprova&#231;&#227;o do Conselho de Revis&#227;o Institucional foi obtida da Universidad Pontificia Bolivariana&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Dois dos pesquisadores foram respons&#225;veis pela coleta de dados e imagens dermatosc&#243;picas&#46; Foram criados dois bancos de dados utilizando Microsoft Excel e Microsoft PowerPoint&#44; onde foram organizadas informa&#231;&#245;es e imagens&#46; A dermatoscopia foi realizada com um aparelho de luz polarizada &#40;DermLite DL4&#44; 3 Gen&#44; LLC&#44; San Juan Capistrano&#44; Calif&#243;rnia&#44; EUA &#8211; FotoFinder ATBM&#44; Bad Birnbach&#44; Alemanha&#41; e as imagens dermatosc&#243;picas foram adquiridas com c&#226;mera de alta resolu&#231;&#227;o adaptada ao dispositivo dermatosc&#243;pico&#46; As fotos foram avaliadas por dois observadores independentes para caracter&#237;sticas dermatosc&#243;picas predefinidas&#46; Em caso de discord&#226;ncia&#44; uma terceira avalia&#231;&#227;o foi realizada e um consenso foi alcan&#231;ado&#46; O tamanho do tumor foi medido digitalmente&#44; com base no maior di&#226;metro&#46; Os CBCs foram classificados de acordo com seu tamanho em tr&#234;s grupos&#58; 1&#41; CBCsPD &#40;medindo menos de 3<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; 2&#41; CBCs pequenos &#40;de 3 a 5<span class="elsevierStyleHsp" style=""></span>mm&#41; e 3&#41; CBCs m&#233;dios &#40;de 5 a 10<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; Os dois &#250;ltimos foram agrupados como CBCs de refer&#234;ncia ou controle &#40;de 3 a 10<span class="elsevierStyleHsp" style=""></span>mm&#41; para compara&#231;&#227;o com os CBCsPD&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As caracter&#237;sticas demogr&#225;ficas&#44; cl&#237;nicas&#44; histopatol&#243;gicas e terap&#234;uticas foram obtidas a partir de prontu&#225;rios m&#233;dicos e relat&#243;rios de histopatologia e inclu&#237;ram&#58; idade&#44; sexo&#44; ocupa&#231;&#227;o&#44; hist&#243;ria pessoal de c&#226;ncer de pele n&#227;o melanoma &#40;CPNM&#41; ou melanoma&#44; fototipo de pele de Fitzpatrick&#44; sinais de fotodano local&#44; n&#250;mero de les&#245;es por paciente&#44; tamanho e localiza&#231;&#227;o do tumor&#44; sub&#8208;localiza&#231;&#227;o espec&#237;fica em caso de tumores faciais&#44; les&#227;o prim&#225;ria&#44; cor predominante &#40;definida como cor presente em mais da metade da les&#227;o&#41;&#44; pessoa que detectou a les&#227;o&#44; tempo de evolu&#231;&#227;o&#44; tipo histopatol&#243;gico&#44; profundidade tumoral&#44; concord&#226;ncia cl&#237;nicopatol&#243;gica&#44; modalidade de tratamento e&#44; no caso de cirurgia microgr&#225;fica de Mohs &#40;CMM&#41;&#44; n&#250;mero de est&#225;gios&#44; tipo histol&#243;gico na cirurgia e concord&#226;ncia com histopatologia anterior&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Foram analisados os seguintes crit&#233;rios dermatosc&#243;picos do CBC&#58; 1&#41; aus&#234;ncia de rede pigmentar&#59; 2&#41; vasos&#58; vasos arboriformes&#44; telangiectasias curtas&#8208;finas &#40;SFT&#44; do ingl&#234;s <span class="elsevierStyleItalic">short&#8208;fine telangiectasias</span>&#41;&#44; vasos em &#8220;grampo de cabelo&#8221;&#44; vasos em &#8220;saca&#8208;rolhas&#8221;&#44; vasos glomerulares ou pontilhados&#44; vasos em &#8220;v&#237;rgula&#8221; e lineares irregulares&#44; vasos polimorfos &#40;definidos como duas ou mais morfologias&#41;&#44; &#225;reas vermelho&#8208;leitosas e gl&#243;bulos vermelhos&#59; 3&#41; estruturas pigmentadas&#58; estruturas em folha&#44; estruturas em roda raiada&#44; gl&#243;bulos cinza&#8208;azulados&#44; ninhos ovoides&#44; estruturas conc&#234;ntricas e pontos cinza&#8208;azulados&#59; 4&#41; estruturas brancas brilhantes &#40;SWS&#44; do ingl&#234;s <span class="elsevierStyleItalic">shiny white structures</span>&#41;&#58; &#225;reas amorfas e cord&#245;es&#44; rosetas e estrias &#40;estruturas ortogonais&#41;&#59; 5&#41; escamas&#58; brancas ou amarelas&#59; e 6&#41; outras estruturas&#58; ulcera&#231;&#227;o&#44; microeros&#245;es&#44; gl&#243;bulos amarelos agregados m&#250;ltiplos &#40;gl&#243;bulos MAY&#41;&#44; v&#233;u azul&#8208;esbranqui&#231;ado e cistos semelhantes a milia&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">As vari&#225;veis quantitativas foram apresentadas como m&#233;dia e desvio padr&#227;o &#40;DP&#41;&#44; de acordo com a distribui&#231;&#227;o normal das vari&#225;veis avaliadas pelo teste de Kolmogorov&#8208;Smirnov&#46; Em caso de n&#227;o normalidade&#44; medianas e intervalos interquartis foram obtidos&#46; O tamanho foi a vari&#225;vel dependente&#44; classificado em tr&#234;s grupos&#44; como mencionado anteriormente&#46; As caracter&#237;sticas dermatosc&#243;picas foram comparadas entre os grupos com os testes estat&#237;sticos de qui&#8208;quadrado ou de Fisher&#44; dependendo do valor esperado &#40;signific&#226;ncia estat&#237;stica&#44; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; O banco de dados foi exportado para o <span class="elsevierStyleItalic">software</span> IBM SPSS Statistics 24&#46;0 para an&#225;lise estat&#237;stica&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Caracter&#237;sticas demogr&#225;ficas</span><p id="par0045" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos 196 pacientes&#44; totalizando 326 CBCs&#46; No total de pacientes&#44; 60&#37; eram do sexo masculino &#40;117&#47;196&#41;&#46; A mediana da idade foi de 66&#44;5 anos &#40;IIQ&#58; 56&#8211;76&#41;&#59; 71&#37; &#40;140&#47;196&#41; apresentavam uma &#250;nica les&#227;o e apenas 8&#37; &#40;16&#47;196&#41; apresentavam quatro ou mais les&#245;es&#46; Exposi&#231;&#227;o cr&#244;nica ao sol estava presente em 18&#37; dos pacientes &#40;36&#47;196&#41;&#46; A maioria dos casos tinha hist&#243;ria pessoal de CPNM &#40;61&#37; &#8211; 119&#47;196&#41;&#44; enquanto uma minoria tinha hist&#243;ria de melanoma &#40;7&#37; &#63; 14&#47;196&#41;&#46; O fototipo de pele mais comum foi o Fitzpatrick tipo III&#44; encontrado em 59&#37; &#40;116&#47;196&#41; dos pacientes&#46; Outras caracter&#237;sticas s&#227;o descritas com mais detalhes na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; N&#227;o houve diferen&#231;as estatisticamente significantes entre CBCsPD e de refer&#234;ncia em rela&#231;&#227;o &#224;s caracter&#237;sticas demogr&#225;ficas&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Caracter&#237;sticas cl&#237;nicas&#44; histopatol&#243;gicas e terap&#234;uticas</span><p id="par0050" class="elsevierStylePara elsevierViewall">As frequ&#234;ncias foram determinadas com base em todas as les&#245;es observadas &#40;326&#41;&#46; A les&#227;o prim&#225;ria foi uma p&#225;pula n&#227;o ulcerada em 48&#37; &#40;156&#47;326&#41; dos tumores&#46; Rosa foi a cor predominante em 46&#37; &#40;149&#47;326&#41;&#44; seguida de marrom e vermelho&#46; A cor marrom foi mais prevalente nos CBCsPD &#40;39&#37; <span class="elsevierStyleItalic">vs</span>&#46; 16&#37; nos CBCs de refer&#234;ncia&#41;&#44; sem signific&#226;ncia estat&#237;stica&#44; enquanto o rosa como cor principal foi mais comum quando o tamanho era maior &#40;33&#37; <span class="elsevierStyleItalic">vs</span>&#46; 50&#37;&#41;&#46; Sinais locais de fotodano foram encontrados em 81&#37; &#40;263&#47;326&#41; das les&#245;es&#46; As les&#245;es foram detectadas pelos dermatologistas em 81&#37; dos casos&#44; enquanto os pacientes detectaram com mais frequ&#234;ncia CBCs controle do que pequeno di&#226;metro&#46; Apenas 12&#37; &#40;40&#47;326&#41; dos tumores tiveram tempo de evolu&#231;&#227;o conhecido&#44; de um a 24 meses&#46; A impress&#227;o diagn&#243;stica foi CBC em 98&#37; &#40;320&#47;326&#41;&#44; mesmo em CBCsPD&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Os tumores tinham tamanho m&#233;dio de 5<span class="elsevierStyleHsp" style=""></span>mm &#40;IIQ&#58; 3&#44;375&#8211;7&#41;&#46; CBCsPD representaram 25&#37; dos casos &#40;81&#47;326&#41;&#44; 39&#37; les&#245;es mediram de 3 a 5<span class="elsevierStyleHsp" style=""></span>mm &#40;127&#47;326&#41; e 36&#37; de 5 a 10<span class="elsevierStyleHsp" style=""></span>mm &#40;118&#47;326&#41;&#46; Os dois &#250;ltimos representaram o grupo de CBCs de refer&#234;ncia em 75&#37; &#40;245&#47;326&#41;&#46; A localiza&#231;&#227;o mais frequente foi face&#47;pesco&#231;o&#44; em 53&#37; &#40;174&#47;326&#41;&#46; Nos CBCsPD foi ainda mais comum&#44; em 69&#37;&#59; al&#233;m disso&#44; &#224; medida que o tamanho do tumor aumentava&#44; as localiza&#231;&#245;es extrafaciais eram mais comuns &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46; As principais localiza&#231;&#245;es das les&#245;es faciais foram nariz 28&#37; &#40;45&#47;160&#41;&#44; regi&#227;o bucinadora 26&#37; &#40;41&#47;160&#41; e regi&#227;o frontal &#40;26&#37;&#41;&#44; sem diferen&#231;a estatisticamente significante entre os diferentes tamanhos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;16&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Os tipos histopatol&#243;gicos predominantes foram nodular em 78&#37; &#40;255&#47;326&#41;&#44; superficial em 26&#37; &#40;83&#47;326&#41; e micronodular em 6&#37; &#40;21&#47;326&#41;&#46; O tipo nodular foi encontrado em 93&#37; &#40;75&#47;81&#41; dos CBCsPD <span class="elsevierStyleItalic">versus</span> 74&#37; &#40;180&#47;245&#41; dos CBCs de refer&#234;ncia &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#59; por outro lado&#44; o tipo superficial estava presente em 9&#37; &#40;7&#47;81&#41; dos CBCs miniaturizados <span class="elsevierStyleItalic">versus</span> 31&#37; &#40;76&#47;245&#41; dos CBCs de controle &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Tipos histopatol&#243;gicos agressivos tiveram frequ&#234;ncias semelhantes em ambos os grupos&#46; A maioria das les&#245;es tinha profundidade de 1 a 2<span class="elsevierStyleHsp" style=""></span>mm &#40;70&#37;&#41;&#59; ainda assim&#44; os tumores de pequeno di&#226;metro eram menos profundos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#41;&#46; A <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> fornece mais detalhes sobre as caracter&#237;sticas clinicopatol&#243;gicas&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o ao tratamento&#44; 42&#37; &#40;138&#47;326&#41; receberam CMM&#44; 24&#37; &#40;77&#47;326&#41; foram submetidos a ressec&#231;&#227;o convencional&#44; 3&#37; &#40;11&#47;326&#41; foram ressecados sem biopsia pr&#233;via em virtude da imagem altamente sugestiva e cen&#225;rios espec&#237;ficos e 31&#37; &#40;100&#47;326&#41; n&#227;o tinham recebido tratamento ao final da coleta de dados&#46; Dos submetidos &#224; CMM &#40;138&#41;&#44; o tipo nodular foi documentado em 87&#37; &#40;120&#47;138&#41;&#44; superficial em 21&#37;&#44; micronodular em 7&#37;&#44; infiltrativo em 6&#37; e metat&#237;pico em 1&#37;&#46; Um total de dois est&#225;gios foi necess&#225;rio em 88&#37; dos casos &#40;122&#47;138&#41;&#46; No entanto&#44; n&#227;o foram encontradas diferen&#231;as estatisticamente significantes em rela&#231;&#227;o &#224;s caracter&#237;sticas terap&#234;uticas&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Caracter&#237;sticas dermatosc&#243;picas</span><p id="par0070" class="elsevierStylePara elsevierViewall">Rede pigmentar n&#227;o foi identificada em nenhuma les&#227;o&#46; As cinco estruturas mais prevalentes foram&#58; SFT&#44; encontrada em 62&#37; &#40;203&#47;326&#41;&#44; seguida de pontos cinza&#8208;azulados&#44; em 57&#37; &#40;186&#47;326&#41;&#44; &#225;reas amorfas e cord&#245;es SWS em 56&#37; &#40;184&#47;326&#41;&#44; vasos arboriformes em 38&#37; &#40;124 &#47;326&#41; e gl&#243;bulos cinza&#8208;azulados em 24&#37; &#40;78&#47;326&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Vasos foram identificados em 83&#37; dos casos &#40;271&#47;326&#41; e foram significantemente menos prevalentes em CBCsPD correspondendo a 68&#37; &#40;55&#47;81&#41; do que em CBCs de refer&#234;ncia&#44; 88&#37; &#40;216&#47;245&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Vasos arboriformes foram encontrados em 38&#37; de todos os tumores &#40;124&#47;326&#41;&#44; sem diferen&#231;as significantes entre os grupos&#46; SFT foi a morfologia mais comum&#44; encontrada em 62&#37; &#40;203&#47;326&#41; das les&#245;es&#44; e significantemente menos frequentes em CBCsPD&#44; 52&#37; &#40;42&#47;81&#41; do que em CBCs de refer&#234;ncia&#44; 66&#37; &#40;161&#47;245&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#59; entretanto&#44; foi o achado vascular mais comum no primeiro grupo&#46; Achados vasculares menos comuns inclu&#237;ram vasos em grampo de cabelo&#44; glomerulares&#44; pontilhados&#44; irregulares lineares&#44; em v&#237;rgula e saca&#8208;rolhas&#59; vasos polimorfos estavam presentes em 21&#37; &#40;67&#47;326&#41; das les&#245;es&#46; Nenhum desses &#250;ltimos apresentou diferen&#231;a estatisticamente significante entre os grupos de estudo&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Estruturas pigmentadas foram encontradas em 68&#37; &#40;221&#47;326&#41; e foram mais frequentes nos CBCsPD&#44; 83&#37; &#40;67&#47;81&#41;&#44; do que nos CBCs de refer&#234;ncia&#44; 63&#37; &#40;154&#47;245&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Pontos cinza&#8208;azulados foram a estrutura pigmentada mais comum &#40;57&#37;&#59; 186&#47;326&#41;&#44; e tamb&#233;m foram estatisticamente mais prevalentes em CBCsPD &#40;67&#37; <span class="elsevierStyleItalic">vs</span>&#46; 54&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#46; Outras caracter&#237;sticas pigmentadas encontradas foram&#44; em ordem decrescente&#58; gl&#243;bulos cinza&#8208;azulados&#44; ninhos ovoides&#44; estruturas em folha&#44; estruturas em roda raiada e&#44; finalmente&#44; estruturas conc&#234;ntricas&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">SWS&#44; especialmente &#225;reas amorfas e cord&#245;es&#44; foram significantemente menos frequentes em CBCsPD&#44; 27&#37; &#40;22&#47;81&#41; do que nos tumores de refer&#234;ncia&#44; 66&#37; &#40;162&#47;245&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Escamas tamb&#233;m foram menos comuns em CBCsPD &#40;11&#37; <span class="elsevierStyleItalic">vs</span>&#46; 31&#37;&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; assim como ulcera&#231;&#245;es e microeros&#245;es&#46; Mais detalhes podem ser consultados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Ao comparar caracter&#237;sticas cl&#225;ssicas de CBCs entre os de pequeno di&#226;metro e os de refer&#234;ncia&#44; gl&#243;bulos azul&#8208;acinzentados e ninhos ovoides foram mais frequentes nos primeiros&#46; Em rela&#231;&#227;o a caracter&#237;sticas n&#227;o cl&#225;ssicas&#44; os pontos cinza&#8208;azulados foram mais comuns nas les&#245;es miniaturizadas&#44; enquanto as demais caracter&#237;sticas foram menos frequentes nesse grupo &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Os de pequeno di&#226;metro foram caracterizados pela presen&#231;a de pontos azul&#8208;acinzentados &#40;67&#37;&#41; e ocasionalmente SFT &#40;52&#37;&#59; <a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1 e 2</a>&#41;&#46; Os primeiros tinham distribui&#231;&#227;o difusa em 43&#37; &#40;23&#47;54&#41; e agrupada em 41&#37; &#40;22&#47;54&#41;&#46; Gl&#243;bulos cinza&#8208;azulados e ninhos ovoides estavam presentes em 30&#37; e 24&#37; dessas les&#245;es&#44; enquanto vasos arboriformes foram encontrados em 33&#37;&#46; SWS&#44; escamas&#44; ulcera&#231;&#245;es e microeros&#245;es foram raramente observadas&#46; Apenas 12&#37; &#40;10&#47;81&#41; apresentavam uma caracter&#237;stica dermatosc&#243;pica isolada&#44; geralmente pontos ou vasos arboriformes em 30&#37; &#40;3&#47;10&#44; cada um&#59; <a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#59; duas caracter&#237;sticas foram observadas em 20&#37; &#40;16&#47;81&#41;&#44; nas quais pontos com SFT ou gl&#243;bulos foram as combina&#231;&#245;es mais comuns &#40;3&#47;16 &#8211; 19&#37;&#44; cada uma&#41;&#46; Al&#233;m disso&#44; 68&#37; tinham tr&#234;s ou mais caracter&#237;sticas&#46; Em 84&#37; das les&#245;es miniaturizadas&#44; o caos dermatosc&#243;pico foi percept&#237;vel &#40;68&#47;81&#41;&#46; Imagens dermatosc&#243;picas de CBCsPD s&#227;o mostradas nas <a class="elsevierStyleCrossRefs" href="#fig0005">figuras 1&#8208;3</a>&#44; e imagens de CBCs de refer&#234;ncia s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#fig0020">figura 4</a>&#46; Para mais informa&#231;&#245;es&#44; consulte as <a class="elsevierStyleCrossRef" href="#sec0065">tabelas suplementares &#40;S1&#8211;S5&#41;</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Discuss&#227;o</span><p id="par0100" class="elsevierStylePara elsevierViewall">A dermatoscopia tem alta acur&#225;cia e precis&#227;o no diagn&#243;stico do CBC&#44; o que favorece a suspeita mais precoce de malignidade detectando tumores menores&#46; Neste estudo&#44; os autores avaliaram 326 CBCs de 196 pacientes&#46; CBCsPD representaram 81 dos tumores&#46; Frequentemente apresentavam a cor marrom como predominante &#40;39&#37;&#41; e comumente apresentavam o tipo nodular na histopatologia &#40;93&#37;&#41; e raramente o tipo superficial &#40;9&#37;&#41;&#46; Curiosamente&#44; os tipos agressivos tiveram frequ&#234;ncias semelhantes&#44; independente do tamanho do tumor&#46; A maioria das les&#245;es menores localizava&#8208;se na face e no pesco&#231;o&#44; em concord&#226;ncia com a literatura atual&#59;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">19&#44;20</span></a> al&#233;m disso&#44; &#224; medida que aumentava o tamanho&#44; a preval&#234;ncia em outras &#225;reas tamb&#233;m aumentava&#46; Essas les&#245;es eram mais propensas a receber CMM&#44; realizada em 48&#37; dos CBCsPD <span class="elsevierStyleItalic">versus</span> 40&#37; dos CBCs de refer&#234;ncia&#59; em 95&#37; &#40;37&#47;39&#41; dos CBCsPD submetidos &#224; CMM foi necess&#225;rio mais de um est&#225;gio para obter margens cir&#250;rgicas negativas&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Na dermatoscopia dos CBCsPD&#44; a presen&#231;a de estruturas pigmentadas foi a caracter&#237;stica dermatosc&#243;pica mais frequente &#40;83&#37;&#41;&#44; principalmente pontos azul&#8208;acinzentados &#40;67&#37;&#41;&#44; que foram mais frequentes nesses tumores quando comparados aos CBCs maiores&#46; Por outro lado&#44; vasos foram menos frequentes em CBCsPD&#44; especialmente SFT&#44; assim como SWS&#44; escamas&#44; ulcera&#231;&#245;es e microeros&#245;es&#46; As estruturas vasculares mais comuns foram SFT &#40;52&#37;&#41; e vasos arboriformes &#40;33&#37;&#41;&#46; Das les&#245;es com SFT&#44; apenas 7&#37; &#40;3&#47;42&#41; correspondiam ao tipo histopatol&#243;gico superficial&#44; 2&#37; &#40;1&#47;42&#41; ao tipo misto micronodular e infiltrativo&#44; e 91&#37; &#40;38&#47;42&#41; delas eram nodulares&#46; Isso significa que as SFT&#44; neste estudo&#44; n&#227;o estavam presentes no contexto de CBC superficial&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Em CBCsPD nodulares &#40;75&#47;81&#41;&#44; pontos azul&#8208;acinzentados tamb&#233;m foram a caracter&#237;stica mais frequente encontrada&#44; em 68&#37; &#40;51&#47;75&#41;&#46; Vasos foram encontrados em 65&#37; &#40;49&#47;75&#41; dos tumores&#44; principalmente SFT em 51&#37; &#40;38&#47;75&#41; e vasos arboriformes em 35&#37; &#40;26&#47;75&#41;&#46; Tipos histopatol&#243;gicos de alto risco foram encontrados em seis les&#245;es miniaturizadas&#46; A maioria apresentava vasos como principal caracter&#237;stica dermatosc&#243;pica &#40;83&#37;&#41;&#44; principalmente vasos arboriformes &#40;67&#37;&#41;&#44; seguidos de SFT &#40;50&#37;&#41;&#46; Curiosamente&#44; nesses tumores&#44; os pontos cinza&#8208;azulados n&#227;o eram t&#227;o comuns &#40;33&#37;&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Nos CBCsPD superficiais &#40;7&#47;81&#41;&#44; a caracter&#237;stica mais comum tamb&#233;m foi a presen&#231;a de estruturas pigmentadas em 86&#37; &#40;6&#47;7&#41;&#44; principalmente pontos azul&#8208;acinzentados &#40;57&#37;&#41;&#44; seguidos por ninhos ovoides e estruturas em folha &#40;43&#37; cada&#41;&#46; Vasos foram encontrados em 71&#37; &#40;5&#47;7&#41; dessas les&#245;es e&#44; curiosamente&#44; eram polimorfos em todos os casos&#44; com predom&#237;nio da morfologia glomerular em 57&#37; &#40;4&#47;7&#41;&#44; seguido de SFT em 43&#37; &#40;3&#47;7&#41;&#59; entretanto&#44; vasos arboriformes n&#227;o foram identificados&#46; Apenas uma dessas les&#245;es apresentou microeros&#245;es&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Takahashi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> publicaram um estudo comparando CBCs &#8804; 3<span class="elsevierStyleHsp" style=""></span>mm &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41; com CBCs de 4 a 6<span class="elsevierStyleHsp" style=""></span>mm &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41;&#46; Pontos e gl&#243;bulos cinza&#8208;azulados estavam presentes em 100&#37; dos casos do primeiro grupo e ninhos em 67&#37;&#44; ao contr&#225;rio do presente estudo&#44; onde foram encontrados em 67&#37;&#44; 30&#37; e 24&#37; dos CBCsPD&#44; respectivamente&#46; Al&#233;m disso&#44; foram encontradas apenas 9&#37; de les&#245;es com pontos cinza&#8208;azulados no grupo de 4 a 6<span class="elsevierStyleHsp" style=""></span>mm&#44; ao contr&#225;rio dos resultados do presente estudo&#44; que mostraram que eles estavam presentes em 54&#37; dos CBCs de refer&#234;ncia&#46; A principal limita&#231;&#227;o de seu estudo foi o pequeno tamanho da amostra&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Sanchez&#8208;Martin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> publicaram um estudo com 100 CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm&#44; divididos em dois grupos&#44; comparando CBCs pequenos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#41; com CBCs maiores &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>66&#41;&#46; A estrutura dermatosc&#243;pica mais frequente foi SFT &#40;78&#37;&#41;&#44; seguida de pontos cinza&#8208;azulados &#40;55&#37;&#41;&#46; No entanto&#44; os autores n&#227;o encontraram diferen&#231;a estatisticamente significante entre os CBCsPD e maiores&#44; diferindo dos resultados do presente estudo &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Longo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> compararam CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm com les&#245;es controle&#46; Eles descobriram que CBCs pequenos eram mais prevalentes em pacientes mais jovens&#44; em contraste com os resultados do presente estudo&#44; uma vez que os autores n&#227;o encontraram associa&#231;&#227;o entre idade e tamanho tumoral&#46; O padr&#227;o nodular tamb&#233;m foi o tipo mais frequente em seu estudo&#44; com <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; de 3&#44;4&#46; Os autores encontraram dois preditores dermatosc&#243;picos de CBCs pequenos&#58; pontos azul&#8208;acinzentados e ninhos ovoides&#59; entretanto&#44; essas caracter&#237;sticas tinham OR fracos e seu intervalo de confian&#231;a cruzou a unidade em ambos os casos&#46; Quase todas as caracter&#237;sticas dermatosc&#243;picas foram observadas igualmente em ambos os grupos&#44; e a &#250;nica diferen&#231;a estatisticamente significante foi a menor frequ&#234;ncia de ulcera&#231;&#227;o e microeros&#245;es em CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm&#46; Di Meo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> coletaram dados de 100 CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm de um banco de dados e avaliaram a concord&#226;ncia global entre observadores com baixa experi&#234;ncia dermatosc&#243;pica&#46; Eles encontraram baixo n&#237;vel de concord&#226;ncia para alguns dos crit&#233;rios cl&#225;ssicos do CBC e nenhuma concord&#226;ncia para quase todos os crit&#233;rios n&#227;o cl&#225;ssicos&#46; Como visto no presente estudo&#44; a presen&#231;a de pontos azul&#8208;acinzentados&#44; uma caracter&#237;stica n&#227;o cl&#225;ssica&#44; &#233; fundamental para detectar les&#245;es incipientes&#46; Isso confirma a import&#226;ncia de sempre avaliar crit&#233;rios cl&#225;ssicos e n&#227;o cl&#225;ssicos&#44; pois os &#250;ltimos podem se correlacionar com est&#225;dio tumoral precoce&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">O presente estudo tem algumas limita&#231;&#245;es&#46; Os casos foram coletados em um centro de refer&#234;ncia em c&#226;ncer de pele&#44; o que pode alterar as caracter&#237;sticas demogr&#225;ficas dos pacientes&#46; Por ter sido realizado na Col&#244;mbia&#44; a maioria dos fototipos variou de I a IV&#44; com menos dados de fototipos de pele mais claros e mais escuros&#46; Resta confirmar em estudos maiores&#44; com seguimento em longo prazo&#44; se a detec&#231;&#227;o precoce de les&#245;es miniaturizadas melhora com a dermatoscopia&#44; e qual &#233; seu valor progn&#243;stico&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclus&#227;o</span><p id="par0140" class="elsevierStylePara elsevierViewall">Na dermatoscopia de CBCsPD &#40;&#8804; 3<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; as estruturas pigmentadas s&#227;o mais frequentes&#44; principalmente os pontos azul&#8208;acinzentados&#44; enquanto vasos e SWS s&#227;o menos prevalentes&#46; Assim&#44; ao avaliar uma les&#227;o menor que 3<span class="elsevierStyleHsp" style=""></span>mm com suspeita de CBC&#44; pontos azul&#8208;acinzentados e caracter&#237;sticas pigmentadas devem ser ativamente procurados&#44; pois sua presen&#231;a se correlaciona com CBC&#46; Este estudo apresenta evid&#234;ncias robustas que podem favorecer o diagn&#243;stico precoce em est&#225;dios iniciais do crescimento tumoral&#44; aumentando a probabilidade de resultados aceit&#225;veis e funcionais ap&#243;s o tratamento&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Suporte financeiro</span><p id="par0145" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Contribui&#231;&#227;o dos autores</span><p id="par0150" class="elsevierStylePara elsevierViewall">Camilo Arias&#8208;Rodriguez&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Ana Maria Mu&#241;oz&#8208;Monsalve&#58; Concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica de conte&#250;do intelectual importante&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Diana Cuesta&#58; Concep&#231;&#227;o e planejamento do estudo&#59; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Susana Mejia&#8208;Mesa&#58; Concep&#231;&#227;o e planejamento do estudo&#59; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Maria Soledad Aluma&#8208;Tenorio&#58; Concep&#231;&#227;o e planejamento do estudo&#59; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflito de interesses</span><p id="par0175" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A dermatoscopia do carcinoma basocelular &#40;CBC&#41; &#233; fundamental para ajudar na investiga&#231;&#227;o de les&#245;es suspeitas&#46; H&#225; escassez de dados publicados sobre dermatoscopia de CBC de pequeno di&#226;metro &#40;&#8804; 3<span class="elsevierStyleHsp" style=""></span>mm&#41; e suas diferen&#231;as em rela&#231;&#227;o a CBCs maiores&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Descrever e comparar as caracter&#237;sticas dermatosc&#243;picas dos CBCs de tamanho &#8804; 3<span class="elsevierStyleHsp" style=""></span>mm com aqueles medindo de 3 a 10<span class="elsevierStyleHsp" style=""></span>mm&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo transversal anal&#237;tico&#44; incluindo CBCs comprovados por histopatologia com imagens fotogr&#225;ficas dermatosc&#243;picas&#44; entre janeiro de 2017 e dezembro de 2022 em um Centro de C&#226;ncer de Pele em Medell&#237;n&#44; Col&#244;mbia&#46; Caracter&#237;sticas demogr&#225;ficas&#44; clinicopatol&#243;gicas e dermatosc&#243;picas foram comparadas entre CBCs de pequeno di&#226;metro e um grupo de refer&#234;ncia&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos 326 CBCs em 196 pacientes&#44; dos quais 60&#37; eram do sexo masculino&#46; O fototipo de Fitzpatrick mais comum foi o III&#46; CBCs de pequeno di&#226;metro representaram 25&#37; das les&#245;es &#40;81&#47;326&#41;&#46; A face e o pesco&#231;o foram as localiza&#231;&#245;es mais frequentes &#40;53&#37;&#41;&#46; O tipo nodular foi mais comum nos tumores pequenos do que nas les&#245;es maiores&#59; o tipo superficial foi menos frequente&#44; e os subtipos agressivos foram igualmente prevalentes em ambos os grupos&#46; Na dermatoscopia&#44; os tumores pequenos foram estatisticamente mais propensos a apresentar estruturas pigmentadas do que as les&#245;es de refer&#234;ncia&#44; especialmente pontos cinza&#8208;azulados &#40;67&#37; <span class="elsevierStyleItalic">vs</span>&#46; 54&#37;&#41;&#44; os vasos foram menos frequentes&#44; principalmente telangiectasias curtas&#8208;finas &#40;SFT&#44; do ingl&#234;s <span class="elsevierStyleItalic">short&#8208;fine telangiectasias</span>&#59; 52&#37; <span class="elsevierStyleItalic">vs</span>&#46; 66&#37;&#41;&#44; assim como estruturas brancas brilhantes &#40;SWS&#44; do ingl&#234;s <span class="elsevierStyleItalic">shiny white structures</span>&#41;&#44; ulcera&#231;&#227;o&#44; microeros&#245;es e escamas&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Amostra latino&#8208;americana&#44; falta de representatividade de fototipos escuros&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A presen&#231;a de estruturas pigmentadas&#44; principalmente pontos cinza&#8208;azulados&#44; foi mais comum em CBCs pequenos quando comparados a les&#245;es maiores&#59; SFT&#44; SWS e outros achados foram menos prevalentes&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Como citar este artigo&#58; Arias&#8208;Rodriguez C&#44; Mu&#241;oz&#8208;Monsalve AM&#44; Cuesta D&#44; Mejia&#8208;Mesa S&#44; Aluma&#8208;Tenorio MS&#46; Dermoscopy of miniaturized basal cell carcinoma &#40;&#8804; 3&#160;mm&#41;&#46; An Bras Dermatol&#46; 2023&#59;98&#58;755&#8211;63&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Trabalho realizado na Aurora Clinic&#44; Specialized Center for Skin Cancer&#44; Medell&#237;n&#44; Col&#244;mbia&#46;</p>"
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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Dermatoscopia de CBCsPD&#46; &#40;A&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado no t&#243;rax exibindo pontos e gl&#243;bulos azul&#8208;acinzentados&#46; &#40;B&#41; CBC de 2&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no couro cabeludo apresentando pontos azul&#8208;acinzentados&#44; gl&#243;bulos e telangiectasias curtas&#8208;finas&#46; &#40;C&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado no dorso nasal com pontos azul&#8208;acinzentados e telangiectasias curtas&#8208;finas &#40;seta preta&#41;&#46; &#40;D&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado no sulco nasolabial&#44; com pontos azul&#8208;acinzentados e vasos arboriformes &#40;seta azul&#41;&#46; &#40;E&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado na regi&#227;o pr&#233;&#8208;auricular exibindo gl&#243;bulos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas&#44; vasos arboriformes &#40;seta azul&#41; e &#225;reas amorfas brancas brilhantes e cord&#245;es&#46; &#40;F&#41; CBC de 2&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no canto interno do olho&#44; com pontos&#44; gl&#243;bulos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas &#40;seta preta&#41; e vasos arboriformes &#40;seta azul&#41;</p>"
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          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Dermatoscopia de CBCs superficiais de pequeno di&#226;metro&#46; &#40;A&#41; CBC de 3<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior exibindo pontos azul&#8208;acinzentados&#44; vasos polimorfos &#40;detalhe aumentado no quadrado&#41; em &#8220;grampo de cabelo&#8221;&#44; &#8220;em v&#237;rgula&#8221;&#44; vasos glomerulares e lineares irregulares e &#225;reas amorfas e estrias brancas brilhantes&#46; &#40;B&#41; CBC de 3<span class="elsevierStyleHsp" style=""></span>mm localizado no t&#243;rax exibindo estruturas em folha&#44; ninhos ovoides&#44; microeros&#245;es e escamas brancas&#46; &#40;C&#41; CBC de 3<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior mostrando pontos e gl&#243;bulos azul&#8208;acinzentados&#44; estruturas em folha&#44; vasos polimorfos &#40;detalhe aumentado no quadrado&#41; com telangiectasias curtas&#8208;finas&#44; vasos em &#8220;grampo de cabelo&#8221; e em &#8220;v&#237;rgula&#8221; e &#225;reas amorfas e estrias brancas brilhantes&#46; &#40;D&#41; CBC de 3<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior apresentando pontos azul&#8208;acinzentados&#44; vasos polimorfos &#40;detalhe aumentado no quadrado&#41; com telangiectasias curtas&#8208;finas e vasos &#8220;em grampo&#8221; e &#225;reas amorfas e estrias brancas brilhantes</p>"
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        "mostrarFloat" => true
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">CBCsPD apresentando uma &#250;nica caracter&#237;stica dermatosc&#243;pica&#46; &#40;A&#41; CBC de 3<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior exibindo pontos azul&#8208;acinzentados&#46; &#40;B&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado na fronte apresentando gl&#243;bulos azul&#8208;acinzentados&#46; &#40;C&#41; CBC de 1&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado na regi&#227;o frontal apresentando uma &#250;nica estrutura em forma de roda raiada&#46; &#40;D&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado no sulco nasal com presen&#231;a de vasos arboriformes</p>"
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          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Dermatoscopia de CBCs de refer&#234;ncia&#46; &#40;A&#41; CBC pequeno de 4<span class="elsevierStyleHsp" style=""></span>mm de di&#226;metro localizado na regi&#227;o retroauricular exibindo estruturas conc&#234;ntricas&#44; pontos e gl&#243;bulos azul&#8208;acinzentados&#46; &#40;B&#41; Pequeno CBC de 4&#44;5<span class="elsevierStyleHsp" style=""></span>mm de di&#226;metro localizado no membro superior apresentando pontos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas&#44; &#225;reas amorfas brancas brilhantes e cord&#245;es&#46; &#40;C&#41; BCC m&#233;dio medindo 8&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior&#44; com presen&#231;a de gl&#243;bulos e pontos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas&#44; microeros&#245;es&#44; &#225;reas amorfas brancas brilhantes&#44; cord&#245;es e estrias&#46; &#40;D&#41; BCC de 10<span class="elsevierStyleHsp" style=""></span>mm localizado no dorso&#44; com in&#250;meras caracter&#237;sticas&#58; estruturas em roda raiada&#44; estruturas conc&#234;ntricas&#44; pontos e gl&#243;bulos azul&#8208;acinzentados&#44; ninhos ovoides&#44; vasos polimorfos com telangiectasias curtas&#8208;finas&#44; vasos pontilhados e glomerulares e &#225;reas amorfas brancas brilhantes e cord&#245;es&#46; &#40;E&#41; CBC de 5&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no dorso apresentando estruturas em folha&#44; ninhos ovoides&#44; pontos azul&#8208;acinzentados&#44; vasos polimorfos em grampo de cabelo&#44; vasos glomerulares e lineares irregulares&#46; &#40;F&#41; CBC de 6&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior exibindo vasos polimorfos com telangiectasias curtas&#8208;finas&#44; vasos em grampo de cabelo e glomerulares&#44; &#225;reas amorfas brancas brilhantes e cord&#245;es e escamas brancas</p>"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sem exposi&#231;&#227;o solar cr&#244;nica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>C&#226;ncer de pele n&#227;o melanoma &#40;CPNM&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">119 &#40;60&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Melanoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Fototipo de pele de Fitzpatrick</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;28&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">116 &#40;59&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;9&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t" scope="col">Caracter&#237;stica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Tamanho&#44; mm</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8804; 3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81 &#40;24&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 3 &#8211; 5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">127 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 5 &#8211; 10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">118 &#40;36&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Localiza&#231;&#227;o</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Face e pesco&#231;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">174 &#40;53&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Membros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;20&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tronco&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Couro cabeludo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sinais de fotodano local&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">263 &#40;80&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Les&#227;o prim&#225;ria</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>P&#225;pula n&#227;o ulcerada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">156 &#40;47&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placa n&#227;o ulcerada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">142 &#40;43&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>P&#225;pula ulcerada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;4&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placa ulcerada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>M&#225;cula&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Cor predominante</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Rosa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149 &#40;45&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Marrom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;21&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Vermelha&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Cor da pele&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Azul&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Cinza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Preta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Branca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Amarela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Tipo histopatol&#243;gico</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Nodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">255 &#40;78&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Superficial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;25&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Micronodular&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Infiltrativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Esclerosante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Metat&#237;pico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Adenoide&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Cerat&#243;tico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Profundidade&#44; mm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8804; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">227 &#40;69&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 1&#8211;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>N&#227;o relatado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor</th></tr><tr title="table-row"><th class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>81&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">271 &#40;83&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;67&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">216 &#40;88&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Telangiectasias curtas&#8208;finas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">203 &#40;62&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;51&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161 &#40;65&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arboriformes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97 &#40;39&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Polimorfos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;20&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Em &#8220;grampo de cabelo&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;13&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glomerulares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;11&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pontilhados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lineares irregulares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;4&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Em &#8220;v&#237;rgula&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;2&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Em &#8220;saca&#8208;rolhas&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas pigmentadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">221 &#40;67&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;82&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">154 &#40;62&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pontos cinza&#8208;azulados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186 &#40;57&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;66&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132 &#40;53&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gl&#243;bulos cinza&#8208;azulados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78 &#40;23&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;29&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ninhos ovoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;23&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas em folha&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;16&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas em roda raiada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;14&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;15&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas conc&#234;ntricas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;7&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas brancas brilhantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;57&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;28&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">165 &#40;67&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;reas amorfas e cord&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">184 &#40;56&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;27&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">162 &#40;66&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rosetas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;6&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;7&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estrias&#44; ortogonais&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escamas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;26&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brancas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;9&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;27&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amarelas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;053&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outras estruturas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ulcera&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;12&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Microeros&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;11&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gl&#243;bulos amarelos agregados m&#250;ltiplos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">V&#233;u azul&#8208;esbranqui&#231;ado&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t">48 &#40;37&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gl&#243;bulos cinza&#8208;azulados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24 &#40;29&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;23&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24 &#40;20&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ninhos ovoides&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">23 &#40;19&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Estruturas em folha&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">54 &#40;16&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;21&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;14&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ulcera&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">42 &#40;12&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas n&#227;o cl&#225;ssicas</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Telangiectasias curtas&#8208;finas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;51&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81 &#40;63&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80 &#40;67&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pontos cinza&#8208;azulados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">186 &#40;57&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;66&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77 &#40;60&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#193;reas amorfas brancas brilhantes e cord&#245;es&nbsp;\t\t\t\t\t\t\n
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Artigo original
Dermatoscopia do carcinoma basocelular de pequeno diâmetro (≤ 3mm)
Camilo Arias‐Rodrigueza,b,
Corresponding author
ariasr16@gmail.com

Autor para correspondência.
, Ana Maria Muñoz‐Monsalveb, Diana Cuestaa, Susana Mejia‐Mesac, Maria Soledad Aluma‐Tenoriob
a Departamento de Dermatologia, Universidad Pontificia Bolivariana, Medellín, Colômbia
b Departamento de Dermatologia, Aurora Specialized Center for Skin Cancer, Medellín, Colômbia
c Departamento de Dermatologia, Universidad El Bosque, Bogotá, Colômbia
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com sensibilidade de 91&#37; e especificidade de 95&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;5</span></a> Possibilita assim a detec&#231;&#227;o precoce e o planejamento do tratamento&#59; ainda assim&#44; a confirma&#231;&#227;o histopatol&#243;gica continua sendo necess&#225;ria para seu diagn&#243;stico&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6&#8211;9</span></a> Atualmente&#44; CBCs menores s&#227;o encontrados com mais frequ&#234;ncia&#44; provavelmente em virtude da cultura de cuidados preventivos e dos avan&#231;os tecnol&#243;gicos&#46; CBCs pequenos foram definidos por alguns autores como aqueles com menos de 5<span class="elsevierStyleHsp" style=""></span>mm&#44; enquanto CBCs menores que 3<span class="elsevierStyleHsp" style=""></span>mm foram denominados de pequeno di&#226;metro &#40;CBCsPD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">10&#8211;15</span></a> Em rela&#231;&#227;o &#224; apresenta&#231;&#227;o cl&#237;nica&#44; CBCs pequenos s&#227;o mais prevalentes em homens mais jovens&#44; na regi&#227;o da face&#44; geralmente s&#227;o pigmentados e seu tipo histopatol&#243;gico mais comum &#233; o nodular&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> A detec&#231;&#227;o em est&#225;dios tumorais iniciais est&#225; relacionada a tratamento mais f&#225;cil&#44; com melhores resultados est&#233;ticos e menor impacto funcional&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> Atualmente&#44; a literatura &#233; clara quanto aos crit&#233;rios dermatosc&#243;picos cl&#225;ssicos e n&#227;o cl&#225;ssicos do CBC&#59; entretanto&#44; poucos estudos sobre dermatoscopia de CBCs pequenos foram realizados&#44; relatando que esses CBCs podem apresentar caracter&#237;sticas dermatosc&#243;picas cl&#225;ssicas e n&#227;o cl&#225;ssicas&#44; com pontos cinza&#8208;azulados e ninhos ovoides como estruturas principais&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">11&#44;12</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Os CBCsPD s&#227;o les&#245;es ainda mais incipientes&#44; que podem apresentar caracter&#237;sticas diferentes em virtude da fase inicial de crescimento tumoral&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#8211;18</span></a> A dermatoscopia nesses tumores n&#227;o foi amplamente estudada&#59; portanto&#44; h&#225; escassez de literatura m&#233;dica relatando e comparando suas caracter&#237;sticas dermatosc&#243;picas com as de CBCs maiores&#46; O objetivo deste estudo foi descrever e comparar as caracter&#237;sticas dermatosc&#243;picas dos CBCs com di&#226;metro &#8804; 3<span class="elsevierStyleHsp" style=""></span>mm com as daqueles de 3 a 10<span class="elsevierStyleHsp" style=""></span>mm de di&#226;metro&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Materiais e m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Este foi um estudo transversal anal&#237;tico realizado entre janeiro de 2017 e dezembro de 2021 em Medell&#237;n&#44; Col&#244;mbia&#46; Os crit&#233;rios de inclus&#227;o compreenderam pacientes com diagn&#243;stico histopatol&#243;gico de CBC&#44; que apresentavam fotos dermatosc&#243;picas com aumento de 10<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>ou 20<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#46; Foram exclu&#237;dos casos de CBC recorrente e casos sem consentimento do paciente para an&#225;lise fotogr&#225;fica&#46; Os casos foram selecionados retrospectiva e prospectivamente em um centro de refer&#234;ncia em c&#226;ncer de pele&#46; Um banco de dados institucional com todos os CBCs diagnosticados foi examinado&#44; e os casos que atenderam aos crit&#233;rios de elegibilidade foram inclu&#237;dos&#46; Prospectivamente&#44; novos casos de CBC com confirma&#231;&#227;o histopatol&#243;gica foram examinados e&#44; se eleg&#237;veis&#44; inclu&#237;dos&#46; O tamanho do estudo foi determinado pelo n&#250;mero total de CBCs que atenderam aos crit&#233;rios de elegibilidade e foram diagnosticados durante o per&#237;odo mencionado&#46; O protocolo do estudo estava de acordo com as diretrizes &#233;ticas da Declara&#231;&#227;o de Helsinki&#46; A aprova&#231;&#227;o do Conselho de Revis&#227;o Institucional foi obtida da Universidad Pontificia Bolivariana&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Dois dos pesquisadores foram respons&#225;veis pela coleta de dados e imagens dermatosc&#243;picas&#46; Foram criados dois bancos de dados utilizando Microsoft Excel e Microsoft PowerPoint&#44; onde foram organizadas informa&#231;&#245;es e imagens&#46; A dermatoscopia foi realizada com um aparelho de luz polarizada &#40;DermLite DL4&#44; 3 Gen&#44; LLC&#44; San Juan Capistrano&#44; Calif&#243;rnia&#44; EUA &#8211; FotoFinder ATBM&#44; Bad Birnbach&#44; Alemanha&#41; e as imagens dermatosc&#243;picas foram adquiridas com c&#226;mera de alta resolu&#231;&#227;o adaptada ao dispositivo dermatosc&#243;pico&#46; As fotos foram avaliadas por dois observadores independentes para caracter&#237;sticas dermatosc&#243;picas predefinidas&#46; Em caso de discord&#226;ncia&#44; uma terceira avalia&#231;&#227;o foi realizada e um consenso foi alcan&#231;ado&#46; O tamanho do tumor foi medido digitalmente&#44; com base no maior di&#226;metro&#46; Os CBCs foram classificados de acordo com seu tamanho em tr&#234;s grupos&#58; 1&#41; CBCsPD &#40;medindo menos de 3<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; 2&#41; CBCs pequenos &#40;de 3 a 5<span class="elsevierStyleHsp" style=""></span>mm&#41; e 3&#41; CBCs m&#233;dios &#40;de 5 a 10<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; Os dois &#250;ltimos foram agrupados como CBCs de refer&#234;ncia ou controle &#40;de 3 a 10<span class="elsevierStyleHsp" style=""></span>mm&#41; para compara&#231;&#227;o com os CBCsPD&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As caracter&#237;sticas demogr&#225;ficas&#44; cl&#237;nicas&#44; histopatol&#243;gicas e terap&#234;uticas foram obtidas a partir de prontu&#225;rios m&#233;dicos e relat&#243;rios de histopatologia e inclu&#237;ram&#58; idade&#44; sexo&#44; ocupa&#231;&#227;o&#44; hist&#243;ria pessoal de c&#226;ncer de pele n&#227;o melanoma &#40;CPNM&#41; ou melanoma&#44; fototipo de pele de Fitzpatrick&#44; sinais de fotodano local&#44; n&#250;mero de les&#245;es por paciente&#44; tamanho e localiza&#231;&#227;o do tumor&#44; sub&#8208;localiza&#231;&#227;o espec&#237;fica em caso de tumores faciais&#44; les&#227;o prim&#225;ria&#44; cor predominante &#40;definida como cor presente em mais da metade da les&#227;o&#41;&#44; pessoa que detectou a les&#227;o&#44; tempo de evolu&#231;&#227;o&#44; tipo histopatol&#243;gico&#44; profundidade tumoral&#44; concord&#226;ncia cl&#237;nicopatol&#243;gica&#44; modalidade de tratamento e&#44; no caso de cirurgia microgr&#225;fica de Mohs &#40;CMM&#41;&#44; n&#250;mero de est&#225;gios&#44; tipo histol&#243;gico na cirurgia e concord&#226;ncia com histopatologia anterior&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Foram analisados os seguintes crit&#233;rios dermatosc&#243;picos do CBC&#58; 1&#41; aus&#234;ncia de rede pigmentar&#59; 2&#41; vasos&#58; vasos arboriformes&#44; telangiectasias curtas&#8208;finas &#40;SFT&#44; do ingl&#234;s <span class="elsevierStyleItalic">short&#8208;fine telangiectasias</span>&#41;&#44; vasos em &#8220;grampo de cabelo&#8221;&#44; vasos em &#8220;saca&#8208;rolhas&#8221;&#44; vasos glomerulares ou pontilhados&#44; vasos em &#8220;v&#237;rgula&#8221; e lineares irregulares&#44; vasos polimorfos &#40;definidos como duas ou mais morfologias&#41;&#44; &#225;reas vermelho&#8208;leitosas e gl&#243;bulos vermelhos&#59; 3&#41; estruturas pigmentadas&#58; estruturas em folha&#44; estruturas em roda raiada&#44; gl&#243;bulos cinza&#8208;azulados&#44; ninhos ovoides&#44; estruturas conc&#234;ntricas e pontos cinza&#8208;azulados&#59; 4&#41; estruturas brancas brilhantes &#40;SWS&#44; do ingl&#234;s <span class="elsevierStyleItalic">shiny white structures</span>&#41;&#58; &#225;reas amorfas e cord&#245;es&#44; rosetas e estrias &#40;estruturas ortogonais&#41;&#59; 5&#41; escamas&#58; brancas ou amarelas&#59; e 6&#41; outras estruturas&#58; ulcera&#231;&#227;o&#44; microeros&#245;es&#44; gl&#243;bulos amarelos agregados m&#250;ltiplos &#40;gl&#243;bulos MAY&#41;&#44; v&#233;u azul&#8208;esbranqui&#231;ado e cistos semelhantes a milia&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">As vari&#225;veis quantitativas foram apresentadas como m&#233;dia e desvio padr&#227;o &#40;DP&#41;&#44; de acordo com a distribui&#231;&#227;o normal das vari&#225;veis avaliadas pelo teste de Kolmogorov&#8208;Smirnov&#46; Em caso de n&#227;o normalidade&#44; medianas e intervalos interquartis foram obtidos&#46; O tamanho foi a vari&#225;vel dependente&#44; classificado em tr&#234;s grupos&#44; como mencionado anteriormente&#46; As caracter&#237;sticas dermatosc&#243;picas foram comparadas entre os grupos com os testes estat&#237;sticos de qui&#8208;quadrado ou de Fisher&#44; dependendo do valor esperado &#40;signific&#226;ncia estat&#237;stica&#44; 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dos pacientes &#40;36&#47;196&#41;&#46; A maioria dos casos tinha hist&#243;ria pessoal de CPNM &#40;61&#37; &#8211; 119&#47;196&#41;&#44; enquanto uma minoria tinha hist&#243;ria de melanoma &#40;7&#37; &#63; 14&#47;196&#41;&#46; O fototipo de pele mais comum foi o Fitzpatrick tipo III&#44; encontrado em 59&#37; &#40;116&#47;196&#41; dos pacientes&#46; Outras caracter&#237;sticas s&#227;o descritas com mais detalhes na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; N&#227;o houve diferen&#231;as estatisticamente significantes entre CBCsPD e de refer&#234;ncia em rela&#231;&#227;o &#224;s caracter&#237;sticas demogr&#225;ficas&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Caracter&#237;sticas cl&#237;nicas&#44; histopatol&#243;gicas e terap&#234;uticas</span><p id="par0050" class="elsevierStylePara elsevierViewall">As frequ&#234;ncias foram determinadas com base em todas as les&#245;es observadas &#40;326&#41;&#46; A les&#227;o prim&#225;ria foi uma p&#225;pula n&#227;o ulcerada em 48&#37; &#40;156&#47;326&#41; dos tumores&#46; Rosa foi a cor predominante em 46&#37; &#40;149&#47;326&#41;&#44; seguida de marrom e vermelho&#46; A cor marrom foi mais prevalente nos CBCsPD &#40;39&#37; <span class="elsevierStyleItalic">vs</span>&#46; 16&#37; nos CBCs de refer&#234;ncia&#41;&#44; sem signific&#226;ncia estat&#237;stica&#44; enquanto o rosa como cor principal foi mais comum quando o tamanho era maior &#40;33&#37; <span class="elsevierStyleItalic">vs</span>&#46; 50&#37;&#41;&#46; Sinais locais de fotodano foram encontrados em 81&#37; &#40;263&#47;326&#41; das les&#245;es&#46; As les&#245;es foram detectadas pelos dermatologistas em 81&#37; dos casos&#44; enquanto os pacientes detectaram com mais frequ&#234;ncia CBCs controle do que pequeno di&#226;metro&#46; Apenas 12&#37; &#40;40&#47;326&#41; dos tumores tiveram tempo de evolu&#231;&#227;o conhecido&#44; de um a 24 meses&#46; A impress&#227;o diagn&#243;stica foi CBC em 98&#37; &#40;320&#47;326&#41;&#44; mesmo em CBCsPD&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Os tumores tinham tamanho m&#233;dio de 5<span class="elsevierStyleHsp" style=""></span>mm &#40;IIQ&#58; 3&#44;375&#8211;7&#41;&#46; CBCsPD representaram 25&#37; dos casos &#40;81&#47;326&#41;&#44; 39&#37; les&#245;es mediram de 3 a 5<span class="elsevierStyleHsp" style=""></span>mm &#40;127&#47;326&#41; e 36&#37; de 5 a 10<span class="elsevierStyleHsp" style=""></span>mm &#40;118&#47;326&#41;&#46; Os dois &#250;ltimos representaram o grupo de CBCs de refer&#234;ncia em 75&#37; &#40;245&#47;326&#41;&#46; A localiza&#231;&#227;o mais frequente foi face&#47;pesco&#231;o&#44; em 53&#37; &#40;174&#47;326&#41;&#46; Nos CBCsPD foi ainda mais comum&#44; em 69&#37;&#59; al&#233;m disso&#44; &#224; medida que o tamanho do tumor aumentava&#44; as localiza&#231;&#245;es extrafaciais eram mais comuns &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46; As principais localiza&#231;&#245;es das les&#245;es faciais foram nariz 28&#37; &#40;45&#47;160&#41;&#44; regi&#227;o bucinadora 26&#37; &#40;41&#47;160&#41; e regi&#227;o frontal &#40;26&#37;&#41;&#44; sem diferen&#231;a estatisticamente significante entre os diferentes tamanhos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;16&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Os tipos histopatol&#243;gicos predominantes foram nodular em 78&#37; &#40;255&#47;326&#41;&#44; superficial em 26&#37; &#40;83&#47;326&#41; e micronodular em 6&#37; &#40;21&#47;326&#41;&#46; O tipo nodular foi encontrado em 93&#37; &#40;75&#47;81&#41; dos CBCsPD <span class="elsevierStyleItalic">versus</span> 74&#37; &#40;180&#47;245&#41; dos CBCs de refer&#234;ncia &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#59; por outro lado&#44; o tipo superficial estava presente em 9&#37; &#40;7&#47;81&#41; dos CBCs miniaturizados <span class="elsevierStyleItalic">versus</span> 31&#37; &#40;76&#47;245&#41; dos CBCs de controle &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Tipos histopatol&#243;gicos agressivos tiveram frequ&#234;ncias semelhantes em ambos os grupos&#46; A maioria das les&#245;es tinha profundidade de 1 a 2<span class="elsevierStyleHsp" style=""></span>mm &#40;70&#37;&#41;&#59; ainda assim&#44; os tumores de pequeno di&#226;metro eram menos profundos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#41;&#46; A <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> fornece mais detalhes sobre as caracter&#237;sticas clinicopatol&#243;gicas&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o ao tratamento&#44; 42&#37; &#40;138&#47;326&#41; receberam CMM&#44; 24&#37; &#40;77&#47;326&#41; foram submetidos a ressec&#231;&#227;o convencional&#44; 3&#37; &#40;11&#47;326&#41; foram ressecados sem biopsia pr&#233;via em virtude da imagem altamente sugestiva e cen&#225;rios espec&#237;ficos e 31&#37; &#40;100&#47;326&#41; n&#227;o tinham recebido tratamento ao final da coleta de dados&#46; Dos submetidos &#224; CMM &#40;138&#41;&#44; o tipo nodular foi documentado em 87&#37; &#40;120&#47;138&#41;&#44; superficial em 21&#37;&#44; micronodular em 7&#37;&#44; infiltrativo em 6&#37; e metat&#237;pico em 1&#37;&#46; Um total de dois est&#225;gios foi necess&#225;rio em 88&#37; dos casos &#40;122&#47;138&#41;&#46; No entanto&#44; n&#227;o foram encontradas diferen&#231;as estatisticamente significantes em rela&#231;&#227;o &#224;s caracter&#237;sticas terap&#234;uticas&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Caracter&#237;sticas dermatosc&#243;picas</span><p id="par0070" class="elsevierStylePara elsevierViewall">Rede pigmentar n&#227;o foi identificada em nenhuma les&#227;o&#46; As cinco estruturas mais prevalentes foram&#58; SFT&#44; encontrada em 62&#37; &#40;203&#47;326&#41;&#44; seguida de pontos cinza&#8208;azulados&#44; em 57&#37; &#40;186&#47;326&#41;&#44; &#225;reas amorfas e cord&#245;es SWS em 56&#37; &#40;184&#47;326&#41;&#44; vasos arboriformes em 38&#37; &#40;124 &#47;326&#41; e gl&#243;bulos cinza&#8208;azulados em 24&#37; &#40;78&#47;326&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Vasos foram identificados em 83&#37; dos casos &#40;271&#47;326&#41; e foram significantemente menos prevalentes em CBCsPD correspondendo a 68&#37; &#40;55&#47;81&#41; do que em CBCs de refer&#234;ncia&#44; 88&#37; &#40;216&#47;245&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Vasos arboriformes foram encontrados em 38&#37; de todos os tumores &#40;124&#47;326&#41;&#44; sem diferen&#231;as significantes entre os grupos&#46; SFT foi a morfologia mais comum&#44; encontrada em 62&#37; &#40;203&#47;326&#41; das les&#245;es&#44; e significantemente menos frequentes em CBCsPD&#44; 52&#37; &#40;42&#47;81&#41; do que em CBCs de refer&#234;ncia&#44; 66&#37; &#40;161&#47;245&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#59; entretanto&#44; foi o achado vascular mais comum no primeiro grupo&#46; Achados vasculares menos comuns inclu&#237;ram vasos em grampo de cabelo&#44; glomerulares&#44; pontilhados&#44; irregulares lineares&#44; em v&#237;rgula e saca&#8208;rolhas&#59; vasos polimorfos estavam presentes em 21&#37; &#40;67&#47;326&#41; das les&#245;es&#46; Nenhum desses &#250;ltimos apresentou diferen&#231;a estatisticamente significante entre os grupos de estudo&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Estruturas pigmentadas foram encontradas em 68&#37; &#40;221&#47;326&#41; e foram mais frequentes nos CBCsPD&#44; 83&#37; &#40;67&#47;81&#41;&#44; do que nos CBCs de refer&#234;ncia&#44; 63&#37; &#40;154&#47;245&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Pontos cinza&#8208;azulados foram a estrutura pigmentada mais comum &#40;57&#37;&#59; 186&#47;326&#41;&#44; e tamb&#233;m foram estatisticamente mais prevalentes em CBCsPD &#40;67&#37; <span class="elsevierStyleItalic">vs</span>&#46; 54&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#46; Outras caracter&#237;sticas pigmentadas encontradas foram&#44; em ordem decrescente&#58; gl&#243;bulos cinza&#8208;azulados&#44; ninhos ovoides&#44; estruturas em folha&#44; estruturas em roda raiada e&#44; finalmente&#44; estruturas conc&#234;ntricas&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">SWS&#44; especialmente &#225;reas amorfas e cord&#245;es&#44; foram significantemente menos frequentes em CBCsPD&#44; 27&#37; &#40;22&#47;81&#41; do que nos tumores de refer&#234;ncia&#44; 66&#37; &#40;162&#47;245&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Escamas tamb&#233;m foram menos comuns em CBCsPD &#40;11&#37; <span class="elsevierStyleItalic">vs</span>&#46; 31&#37;&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; assim como ulcera&#231;&#245;es e microeros&#245;es&#46; Mais detalhes podem ser consultados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Ao comparar caracter&#237;sticas cl&#225;ssicas de CBCs entre os de pequeno di&#226;metro e os de refer&#234;ncia&#44; gl&#243;bulos azul&#8208;acinzentados e ninhos ovoides foram mais frequentes nos primeiros&#46; Em rela&#231;&#227;o a caracter&#237;sticas n&#227;o cl&#225;ssicas&#44; os pontos cinza&#8208;azulados foram mais comuns nas les&#245;es miniaturizadas&#44; enquanto as demais caracter&#237;sticas foram menos frequentes nesse grupo &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Os de pequeno di&#226;metro foram caracterizados pela presen&#231;a de pontos azul&#8208;acinzentados &#40;67&#37;&#41; e ocasionalmente SFT &#40;52&#37;&#59; <a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1 e 2</a>&#41;&#46; Os primeiros tinham distribui&#231;&#227;o difusa em 43&#37; &#40;23&#47;54&#41; e agrupada em 41&#37; &#40;22&#47;54&#41;&#46; Gl&#243;bulos cinza&#8208;azulados e ninhos ovoides estavam presentes em 30&#37; e 24&#37; dessas les&#245;es&#44; enquanto vasos arboriformes foram encontrados em 33&#37;&#46; SWS&#44; escamas&#44; ulcera&#231;&#245;es e microeros&#245;es foram raramente observadas&#46; Apenas 12&#37; &#40;10&#47;81&#41; apresentavam uma caracter&#237;stica dermatosc&#243;pica isolada&#44; geralmente pontos ou vasos arboriformes em 30&#37; &#40;3&#47;10&#44; cada um&#59; <a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#59; duas caracter&#237;sticas foram observadas em 20&#37; &#40;16&#47;81&#41;&#44; nas quais pontos com SFT ou gl&#243;bulos foram as combina&#231;&#245;es mais comuns &#40;3&#47;16 &#8211; 19&#37;&#44; cada uma&#41;&#46; Al&#233;m disso&#44; 68&#37; tinham tr&#234;s ou mais caracter&#237;sticas&#46; Em 84&#37; das les&#245;es miniaturizadas&#44; o caos dermatosc&#243;pico foi percept&#237;vel &#40;68&#47;81&#41;&#46; Imagens dermatosc&#243;picas de CBCsPD s&#227;o mostradas nas <a class="elsevierStyleCrossRefs" href="#fig0005">figuras 1&#8208;3</a>&#44; e imagens de CBCs de refer&#234;ncia s&#227;o mostradas na <a class="elsevierStyleCrossRef" href="#fig0020">figura 4</a>&#46; Para mais informa&#231;&#245;es&#44; consulte as <a class="elsevierStyleCrossRef" href="#sec0065">tabelas suplementares &#40;S1&#8211;S5&#41;</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Discuss&#227;o</span><p id="par0100" class="elsevierStylePara elsevierViewall">A dermatoscopia tem alta acur&#225;cia e precis&#227;o no diagn&#243;stico do CBC&#44; o que favorece a suspeita mais precoce de malignidade detectando tumores menores&#46; Neste estudo&#44; os autores avaliaram 326 CBCs de 196 pacientes&#46; CBCsPD representaram 81 dos tumores&#46; Frequentemente apresentavam a cor marrom como predominante &#40;39&#37;&#41; e comumente apresentavam o tipo nodular na histopatologia &#40;93&#37;&#41; e raramente o tipo superficial &#40;9&#37;&#41;&#46; Curiosamente&#44; os tipos agressivos tiveram frequ&#234;ncias semelhantes&#44; independente do tamanho do tumor&#46; A maioria das les&#245;es menores localizava&#8208;se na face e no pesco&#231;o&#44; em concord&#226;ncia com a literatura atual&#59;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">19&#44;20</span></a> al&#233;m disso&#44; &#224; medida que aumentava o tamanho&#44; a preval&#234;ncia em outras &#225;reas tamb&#233;m aumentava&#46; Essas les&#245;es eram mais propensas a receber CMM&#44; realizada em 48&#37; dos CBCsPD <span class="elsevierStyleItalic">versus</span> 40&#37; dos CBCs de refer&#234;ncia&#59; em 95&#37; &#40;37&#47;39&#41; dos CBCsPD submetidos &#224; CMM foi necess&#225;rio mais de um est&#225;gio para obter margens cir&#250;rgicas negativas&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Na dermatoscopia dos CBCsPD&#44; a presen&#231;a de estruturas pigmentadas foi a caracter&#237;stica dermatosc&#243;pica mais frequente &#40;83&#37;&#41;&#44; principalmente pontos azul&#8208;acinzentados &#40;67&#37;&#41;&#44; que foram mais frequentes nesses tumores quando comparados aos CBCs maiores&#46; Por outro lado&#44; vasos foram menos frequentes em CBCsPD&#44; especialmente SFT&#44; assim como SWS&#44; escamas&#44; ulcera&#231;&#245;es e microeros&#245;es&#46; As estruturas vasculares mais comuns foram SFT &#40;52&#37;&#41; e vasos arboriformes &#40;33&#37;&#41;&#46; Das les&#245;es com SFT&#44; apenas 7&#37; &#40;3&#47;42&#41; correspondiam ao tipo histopatol&#243;gico superficial&#44; 2&#37; &#40;1&#47;42&#41; ao tipo misto micronodular e infiltrativo&#44; e 91&#37; &#40;38&#47;42&#41; delas eram nodulares&#46; Isso significa que as SFT&#44; neste estudo&#44; n&#227;o estavam presentes no contexto de CBC superficial&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Em CBCsPD nodulares &#40;75&#47;81&#41;&#44; pontos azul&#8208;acinzentados tamb&#233;m foram a caracter&#237;stica mais frequente encontrada&#44; em 68&#37; &#40;51&#47;75&#41;&#46; Vasos foram encontrados em 65&#37; &#40;49&#47;75&#41; dos tumores&#44; principalmente SFT em 51&#37; &#40;38&#47;75&#41; e vasos arboriformes em 35&#37; &#40;26&#47;75&#41;&#46; Tipos histopatol&#243;gicos de alto risco foram encontrados em seis les&#245;es miniaturizadas&#46; A maioria apresentava vasos como principal caracter&#237;stica dermatosc&#243;pica &#40;83&#37;&#41;&#44; principalmente vasos arboriformes &#40;67&#37;&#41;&#44; seguidos de SFT &#40;50&#37;&#41;&#46; Curiosamente&#44; nesses tumores&#44; os pontos cinza&#8208;azulados n&#227;o eram t&#227;o comuns &#40;33&#37;&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Nos CBCsPD superficiais &#40;7&#47;81&#41;&#44; a caracter&#237;stica mais comum tamb&#233;m foi a presen&#231;a de estruturas pigmentadas em 86&#37; &#40;6&#47;7&#41;&#44; principalmente pontos azul&#8208;acinzentados &#40;57&#37;&#41;&#44; seguidos por ninhos ovoides e estruturas em folha &#40;43&#37; cada&#41;&#46; Vasos foram encontrados em 71&#37; &#40;5&#47;7&#41; dessas les&#245;es e&#44; curiosamente&#44; eram polimorfos em todos os casos&#44; com predom&#237;nio da morfologia glomerular em 57&#37; &#40;4&#47;7&#41;&#44; seguido de SFT em 43&#37; &#40;3&#47;7&#41;&#59; entretanto&#44; vasos arboriformes n&#227;o foram identificados&#46; Apenas uma dessas les&#245;es apresentou microeros&#245;es&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Takahashi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> publicaram um estudo comparando CBCs &#8804; 3<span class="elsevierStyleHsp" style=""></span>mm &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41; com CBCs de 4 a 6<span class="elsevierStyleHsp" style=""></span>mm &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41;&#46; Pontos e gl&#243;bulos cinza&#8208;azulados estavam presentes em 100&#37; dos casos do primeiro grupo e ninhos em 67&#37;&#44; ao contr&#225;rio do presente estudo&#44; onde foram encontrados em 67&#37;&#44; 30&#37; e 24&#37; dos CBCsPD&#44; respectivamente&#46; Al&#233;m disso&#44; foram encontradas apenas 9&#37; de les&#245;es com pontos cinza&#8208;azulados no grupo de 4 a 6<span class="elsevierStyleHsp" style=""></span>mm&#44; ao contr&#225;rio dos resultados do presente estudo&#44; que mostraram que eles estavam presentes em 54&#37; dos CBCs de refer&#234;ncia&#46; A principal limita&#231;&#227;o de seu estudo foi o pequeno tamanho da amostra&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Sanchez&#8208;Martin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> publicaram um estudo com 100 CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm&#44; divididos em dois grupos&#44; comparando CBCs pequenos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#41; com CBCs maiores &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>66&#41;&#46; A estrutura dermatosc&#243;pica mais frequente foi SFT &#40;78&#37;&#41;&#44; seguida de pontos cinza&#8208;azulados &#40;55&#37;&#41;&#46; No entanto&#44; os autores n&#227;o encontraram diferen&#231;a estatisticamente significante entre os CBCsPD e maiores&#44; diferindo dos resultados do presente estudo &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Longo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> compararam CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm com les&#245;es controle&#46; Eles descobriram que CBCs pequenos eram mais prevalentes em pacientes mais jovens&#44; em contraste com os resultados do presente estudo&#44; uma vez que os autores n&#227;o encontraram associa&#231;&#227;o entre idade e tamanho tumoral&#46; O padr&#227;o nodular tamb&#233;m foi o tipo mais frequente em seu estudo&#44; com <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; de 3&#44;4&#46; Os autores encontraram dois preditores dermatosc&#243;picos de CBCs pequenos&#58; pontos azul&#8208;acinzentados e ninhos ovoides&#59; entretanto&#44; essas caracter&#237;sticas tinham OR fracos e seu intervalo de confian&#231;a cruzou a unidade em ambos os casos&#46; Quase todas as caracter&#237;sticas dermatosc&#243;picas foram observadas igualmente em ambos os grupos&#44; e a &#250;nica diferen&#231;a estatisticamente significante foi a menor frequ&#234;ncia de ulcera&#231;&#227;o e microeros&#245;es em CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm&#46; Di Meo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> coletaram dados de 100 CBCs &#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm de um banco de dados e avaliaram a concord&#226;ncia global entre observadores com baixa experi&#234;ncia dermatosc&#243;pica&#46; Eles encontraram baixo n&#237;vel de concord&#226;ncia para alguns dos crit&#233;rios cl&#225;ssicos do CBC e nenhuma concord&#226;ncia para quase todos os crit&#233;rios n&#227;o cl&#225;ssicos&#46; Como visto no presente estudo&#44; a presen&#231;a de pontos azul&#8208;acinzentados&#44; uma caracter&#237;stica n&#227;o cl&#225;ssica&#44; &#233; fundamental para detectar les&#245;es incipientes&#46; Isso confirma a import&#226;ncia de sempre avaliar crit&#233;rios cl&#225;ssicos e n&#227;o cl&#225;ssicos&#44; pois os &#250;ltimos podem se correlacionar com est&#225;dio tumoral precoce&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">O presente estudo tem algumas limita&#231;&#245;es&#46; Os casos foram coletados em um centro de refer&#234;ncia em c&#226;ncer de pele&#44; o que pode alterar as caracter&#237;sticas demogr&#225;ficas dos pacientes&#46; Por ter sido realizado na Col&#244;mbia&#44; a maioria dos fototipos variou de I a IV&#44; com menos dados de fototipos de pele mais claros e mais escuros&#46; Resta confirmar em estudos maiores&#44; com seguimento em longo prazo&#44; se a detec&#231;&#227;o precoce de les&#245;es miniaturizadas melhora com a dermatoscopia&#44; e qual &#233; seu valor progn&#243;stico&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclus&#227;o</span><p id="par0140" class="elsevierStylePara elsevierViewall">Na dermatoscopia de CBCsPD &#40;&#8804; 3<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; as estruturas pigmentadas s&#227;o mais frequentes&#44; principalmente os pontos azul&#8208;acinzentados&#44; enquanto vasos e SWS s&#227;o menos prevalentes&#46; Assim&#44; ao avaliar uma les&#227;o menor que 3<span class="elsevierStyleHsp" style=""></span>mm com suspeita de CBC&#44; pontos azul&#8208;acinzentados e caracter&#237;sticas pigmentadas devem ser ativamente procurados&#44; pois sua presen&#231;a se correlaciona com CBC&#46; Este estudo apresenta evid&#234;ncias robustas que podem favorecer o diagn&#243;stico precoce em est&#225;dios iniciais do crescimento tumoral&#44; aumentando a probabilidade de resultados aceit&#225;veis e funcionais ap&#243;s o tratamento&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Suporte financeiro</span><p id="par0145" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Contribui&#231;&#227;o dos autores</span><p id="par0150" class="elsevierStylePara elsevierViewall">Camilo Arias&#8208;Rodriguez&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Ana Maria Mu&#241;oz&#8208;Monsalve&#58; Concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; revis&#227;o cr&#237;tica de conte&#250;do intelectual importante&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Diana Cuesta&#58; Concep&#231;&#227;o e planejamento do estudo&#59; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Susana Mejia&#8208;Mesa&#58; Concep&#231;&#227;o e planejamento do estudo&#59; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Maria Soledad Aluma&#8208;Tenorio&#58; Concep&#231;&#227;o e planejamento do estudo&#59; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; reda&#231;&#227;o do manuscrito&#59; revis&#227;o cr&#237;tica da literatura&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflito de interesses</span><p id="par0175" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A dermatoscopia do carcinoma basocelular &#40;CBC&#41; &#233; fundamental para ajudar na investiga&#231;&#227;o de les&#245;es suspeitas&#46; H&#225; escassez de dados publicados sobre dermatoscopia de CBC de pequeno di&#226;metro &#40;&#8804; 3<span class="elsevierStyleHsp" style=""></span>mm&#41; e suas diferen&#231;as em rela&#231;&#227;o a CBCs maiores&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Descrever e comparar as caracter&#237;sticas dermatosc&#243;picas dos CBCs de tamanho &#8804; 3<span class="elsevierStyleHsp" style=""></span>mm com aqueles medindo de 3 a 10<span class="elsevierStyleHsp" style=""></span>mm&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo transversal anal&#237;tico&#44; incluindo CBCs comprovados por histopatologia com imagens fotogr&#225;ficas dermatosc&#243;picas&#44; entre janeiro de 2017 e dezembro de 2022 em um Centro de C&#226;ncer de Pele em Medell&#237;n&#44; Col&#244;mbia&#46; Caracter&#237;sticas demogr&#225;ficas&#44; clinicopatol&#243;gicas e dermatosc&#243;picas foram comparadas entre CBCs de pequeno di&#226;metro e um grupo de refer&#234;ncia&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos 326 CBCs em 196 pacientes&#44; dos quais 60&#37; eram do sexo masculino&#46; O fototipo de Fitzpatrick mais comum foi o III&#46; CBCs de pequeno di&#226;metro representaram 25&#37; das les&#245;es &#40;81&#47;326&#41;&#46; A face e o pesco&#231;o foram as localiza&#231;&#245;es mais frequentes &#40;53&#37;&#41;&#46; O tipo nodular foi mais comum nos tumores pequenos do que nas les&#245;es maiores&#59; o tipo superficial foi menos frequente&#44; e os subtipos agressivos foram igualmente prevalentes em ambos os grupos&#46; Na dermatoscopia&#44; os tumores pequenos foram estatisticamente mais propensos a apresentar estruturas pigmentadas do que as les&#245;es de refer&#234;ncia&#44; especialmente pontos cinza&#8208;azulados &#40;67&#37; <span class="elsevierStyleItalic">vs</span>&#46; 54&#37;&#41;&#44; os vasos foram menos frequentes&#44; principalmente telangiectasias curtas&#8208;finas &#40;SFT&#44; do ingl&#234;s <span class="elsevierStyleItalic">short&#8208;fine telangiectasias</span>&#59; 52&#37; <span class="elsevierStyleItalic">vs</span>&#46; 66&#37;&#41;&#44; assim como estruturas brancas brilhantes &#40;SWS&#44; do ingl&#234;s <span class="elsevierStyleItalic">shiny white structures</span>&#41;&#44; ulcera&#231;&#227;o&#44; microeros&#245;es e escamas&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Amostra latino&#8208;americana&#44; falta de representatividade de fototipos escuros&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A presen&#231;a de estruturas pigmentadas&#44; principalmente pontos cinza&#8208;azulados&#44; foi mais comum em CBCs pequenos quando comparados a les&#245;es maiores&#59; SFT&#44; SWS e outros achados foram menos prevalentes&#46;</p></span>"
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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Dermatoscopia de CBCsPD&#46; &#40;A&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado no t&#243;rax exibindo pontos e gl&#243;bulos azul&#8208;acinzentados&#46; &#40;B&#41; CBC de 2&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no couro cabeludo apresentando pontos azul&#8208;acinzentados&#44; gl&#243;bulos e telangiectasias curtas&#8208;finas&#46; &#40;C&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado no dorso nasal com pontos azul&#8208;acinzentados e telangiectasias curtas&#8208;finas &#40;seta preta&#41;&#46; &#40;D&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado no sulco nasolabial&#44; com pontos azul&#8208;acinzentados e vasos arboriformes &#40;seta azul&#41;&#46; &#40;E&#41; CBC de 2<span class="elsevierStyleHsp" style=""></span>mm localizado na regi&#227;o pr&#233;&#8208;auricular exibindo gl&#243;bulos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas&#44; vasos arboriformes &#40;seta azul&#41; e &#225;reas amorfas brancas brilhantes e cord&#245;es&#46; &#40;F&#41; CBC de 2&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no canto interno do olho&#44; com pontos&#44; gl&#243;bulos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas &#40;seta preta&#41; e vasos arboriformes &#40;seta azul&#41;</p>"
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          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Dermatoscopia de CBCs de refer&#234;ncia&#46; &#40;A&#41; CBC pequeno de 4<span class="elsevierStyleHsp" style=""></span>mm de di&#226;metro localizado na regi&#227;o retroauricular exibindo estruturas conc&#234;ntricas&#44; pontos e gl&#243;bulos azul&#8208;acinzentados&#46; &#40;B&#41; Pequeno CBC de 4&#44;5<span class="elsevierStyleHsp" style=""></span>mm de di&#226;metro localizado no membro superior apresentando pontos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas&#44; &#225;reas amorfas brancas brilhantes e cord&#245;es&#46; &#40;C&#41; BCC m&#233;dio medindo 8&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior&#44; com presen&#231;a de gl&#243;bulos e pontos azul&#8208;acinzentados&#44; telangiectasias curtas&#8208;finas&#44; microeros&#245;es&#44; &#225;reas amorfas brancas brilhantes&#44; cord&#245;es e estrias&#46; &#40;D&#41; BCC de 10<span class="elsevierStyleHsp" style=""></span>mm localizado no dorso&#44; com in&#250;meras caracter&#237;sticas&#58; estruturas em roda raiada&#44; estruturas conc&#234;ntricas&#44; pontos e gl&#243;bulos azul&#8208;acinzentados&#44; ninhos ovoides&#44; vasos polimorfos com telangiectasias curtas&#8208;finas&#44; vasos pontilhados e glomerulares e &#225;reas amorfas brancas brilhantes e cord&#245;es&#46; &#40;E&#41; CBC de 5&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no dorso apresentando estruturas em folha&#44; ninhos ovoides&#44; pontos azul&#8208;acinzentados&#44; vasos polimorfos em grampo de cabelo&#44; vasos glomerulares e lineares irregulares&#46; &#40;F&#41; CBC de 6&#44;5<span class="elsevierStyleHsp" style=""></span>mm localizado no membro superior exibindo vasos polimorfos com telangiectasias curtas&#8208;finas&#44; vasos em grampo de cabelo e glomerulares&#44; &#225;reas amorfas brancas brilhantes e cord&#245;es e escamas brancas</p>"
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">117 &#40;59&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sem exposi&#231;&#227;o solar cr&#244;nica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Exposi&#231;&#227;o solar cr&#244;nica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Desconhecido&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&#8211;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;20&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18 &#40;9&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tronco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Couro cabeludo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sinais de fotodano local&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">263 &#40;80&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Les&#227;o prim&#225;ria</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>P&#225;pula n&#227;o ulcerada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">156 &#40;47&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placa n&#227;o ulcerada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">142 &#40;43&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>P&#225;pula ulcerada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;4&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placa ulcerada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>M&#225;cula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Cor predominante</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Rosa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149 &#40;45&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Marrom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;21&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Vermelha&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Cor da pele&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Azul&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Cinza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Preta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Branca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Amarela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Patologia</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Tipo histopatol&#243;gico</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Nodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">255 &#40;78&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Superficial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;25&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Micronodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Infiltrativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Esclerosante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Metat&#237;pico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Adenoide&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Cerat&#243;tico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Profundidade&#44; mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8804; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">227 &#40;69&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 1&#8211;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>N&#227;o relatado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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            0 => array:3 [
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        "tipo" => "MULTIMEDIATABLA"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;stica</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Qualquer tamanho&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&#8804; 3 mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">3&#8211;10 mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor</th></tr><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>245&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vasos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">271 &#40;83&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;67&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">216 &#40;88&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Telangiectasias curtas&#8208;finas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">203 &#40;62&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;51&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161 &#40;65&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arboriformes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;33&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97 &#40;39&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Polimorfos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;20&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Em &#8220;grampo de cabelo&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;13&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glomerulares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;11&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pontilhados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lineares irregulares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;4&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Em &#8220;v&#237;rgula&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;2&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Em &#8220;saca&#8208;rolhas&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas pigmentadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">221 &#40;67&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;82&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">154 &#40;62&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pontos cinza&#8208;azulados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186 &#40;57&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;66&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132 &#40;53&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gl&#243;bulos cinza&#8208;azulados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78 &#40;23&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;29&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ninhos ovoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;23&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas em folha&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;16&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas em roda raiada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;14&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;15&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas conc&#234;ntricas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;7&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estruturas brancas brilhantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;57&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;28&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">165 &#40;67&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#193;reas amorfas e cord&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">184 &#40;56&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;27&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">162 &#40;66&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rosetas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;6&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;7&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estrias&#44; ortogonais&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escamas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;26&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brancas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;9&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;27&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Amarelas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Ulcera&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">N&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">V&#233;u azul&#8208;esbranqui&#231;ado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">N&#47;A&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;41&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gl&#243;bulos cinza&#8208;azulados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;29&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;23&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;20&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ninhos ovoides&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">64 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19 &#40;23&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">23 &#40;19&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Estruturas em folha&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;15&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ulcera&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#193;reas amorfas brancas brilhantes e cord&#245;es&nbsp;\t\t\t\t\t\t\n
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