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orelha&#44; pr&#233;&#47;p&#243;s&#8208;auricular&#44; genit&#225;lia&#44; m&#227;os e p&#233;s&#41;&#44; envolvimento perineural&#44; les&#245;es recorrentes ap&#243;s cirurgia e&#47;ou radioterapia&#44; imunossupress&#227;o e bordas mal definidas&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas da les&#227;o por exame de congela&#231;&#227;o vem sendo largamente utilizada para tentar assegurar margens livres de doen&#231;a&#44; e &#233; mais seguro em planejar a reconstru&#231;&#227;o definitiva&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> A cirurgia microgr&#225;fica de Mohs &#40;CMM&#41; &#233; uma das t&#233;cnicas propostas para CBC e CEC de alto risco&#44; pois propicia a an&#225;lise intraoperat&#243;ria de 100&#37; da margem de excis&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Por&#233;m&#44; &#233; importante haver uma alternativa aceit&#225;vel e segura para suprir a CMM&#44; pois essa t&#233;cnica pode ser financeiramente invi&#225;vel e limitada em sua disponibilidade&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Outra t&#233;cnica em que tamb&#233;m h&#225; uma avalia&#231;&#227;o completa de todas as margens &#233; a avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas por congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; uma poss&#237;vel alternativa &#224; CMM&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">O termo &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; uma express&#227;o usada para se referir que ao examinar a pe&#231;a cir&#250;rgica durante a congela&#231;&#227;o intraoperat&#243;ria&#44; as se&#231;&#245;es de margens analisadas s&#227;o processadas paralelo &#224; margem cir&#250;rgica&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Nosso objetivo &#233; relatar os resultados da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; quanto &#224; recorr&#234;ncia do tumor e a concord&#226;ncia com os cortes de parafina&#44; na rotina de uma institui&#231;&#227;o&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material e m&#233;todos</span><p id="par0035" class="elsevierStylePara elsevierViewall">An&#225;lise retrospectiva de pacientes submetidos &#224; ex&#233;rese cir&#250;rgica de CBC e CEC pelo N&#250;cleo de C&#226;ncer de Pele do A&#46;C&#46;Camargo Cancer Center&#44; S&#227;o Paulo&#47;SP &#8211; Brasil&#44; entre janeiro a dezembro de 2013&#46; Houve aprova&#231;&#227;o do Comit&#234; de &#201;tica em pesquisa local para estse estudo&#44; n&#176; 2602&#47;18&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Pacientes</span><p id="par0040" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos no estudo pacientes com CBC e&#47;ou CEC&#44; prim&#225;rio ou recorrente&#44; submetidos &#224; t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; independente da topografia da les&#227;o&#46; Os crit&#233;rios de n&#227;o inclus&#227;o foram pacientes com outros tipos de neoplasia cut&#226;neas e pacientes que n&#227;o realizaram a t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Foram avaliados os seguintes dados cl&#237;nicos&#44; epidemiol&#243;gicos&#44; de anatomia patol&#243;gica e tratamento de cada paciente&#58; sexo&#44; idade&#44; tipo e subtipo de tumor&#44; tipo de reconstru&#231;&#227;o&#44; n&#250;mero de ressec&#231;&#245;es necess&#225;rias para obter margens cir&#250;rgicas livre de tumor&#44; o resultado do exame intraoperat&#243;rio de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; e resultado final do anatomopatol&#243;gico ap&#243;s processamento histopatol&#243;gico convencional com confec&#231;&#227;o de blocos de parafina&#44; necessidade de tratamento complementar&#44; tempo de seguimento e recorr&#234;ncia tumoral &#40;a recorr&#234;ncia foi definida como o reaparecimento da les&#227;o no acompanhamento cl&#237;nico confirmado por exame histol&#243;gico&#41;&#46; As les&#245;es prim&#225;rias foram consideradas CBCs ou CECs rec&#233;m&#8208;diagnosticados clinicamente&#44; e as les&#245;es secund&#225;rias foram aquelas que haviam sido tratadas anteriormente em outros hospitais e recorreram&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">An&#225;lise estat&#237;stica</span><p id="par0050" class="elsevierStylePara elsevierViewall">A an&#225;lise descritiva foi realizada com a avalia&#231;&#227;o dos prontu&#225;rios&#46; Regress&#245;es log&#237;sticas simples foram utilizadas para identificar vari&#225;veis que se associaram aos desfechos estudados&#46; Todas as vari&#225;veis com valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 foram inclu&#237;das nos modelos de regress&#227;o log&#237;stica m&#250;ltipla&#46; O software IBM SPSS v 20&#46;0&#174; foi utilizado para a an&#225;lise estat&#237;stica&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">T&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;en face&#8221;</span><p id="par0055" class="elsevierStylePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; propicia o exame de todas as margens do tumor&#46; Todas as margens perif&#233;ricas e profunda da pe&#231;a analisada na congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; foram enviadas para processamento histopatol&#243;gico convencional com confec&#231;&#227;o de blocos de parafina&#46; Assim&#44; foram comparados os resultados do exame intraoperat&#243;rio da congela&#231;&#227;o com o resultado final anatomopatol&#243;gico ap&#243;s processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">O procedimento cir&#250;rgico foi realizado da seguinte maneira&#58; as margens de ressec&#231;&#227;o do tumor cut&#226;neo foram demarcadas com aux&#237;lio de dermatosc&#243;pio manual utilizado pelo cirurgi&#227;o respons&#225;vel pelo procedimento&#44; com o objetivo de alcan&#231;ar margens de ressec&#231;&#227;o livres&#46; N&#227;o foi poss&#237;vel documentar a margem cir&#250;rgica utilizada para a excis&#227;o&#44; por se tratar de um estudo retrospectivo&#46; A excis&#227;o foi realizada sob anestesia geral&#44; anestesia local associada com seda&#231;&#227;o&#44; anestesia local pura ou raquianestesia associada a seda&#231;&#227;o&#44; dependendo das comorbidades do paciente&#44; do planejamento da reconstru&#231;&#227;o e do tamanho da les&#227;o&#46; A excis&#227;o da les&#227;o foi realizada com a borda circunferencial reta e a margem profunda plana&#44; diferindo da forma angulada da ressec&#231;&#227;o CMM&#46; Na <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> demonstramos o aspecto cl&#237;nico da les&#227;o antes da excis&#227;o com delimita&#231;&#227;o dermatosc&#243;pica das margens cir&#250;rgicas&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">O exame intraoperat&#243;rio para avalia&#231;&#227;o de margens cir&#250;rgicas da les&#227;o excisada se inicia com o recebimento pelo patologista do esp&#233;cime a fresco com identifica&#231;&#227;o pr&#233;via pelo cirurgi&#227;o do ponto de refer&#234;ncia do paciente de 12 horas&#46; Todas as margens laterais e profunda do esp&#233;cime s&#227;o ent&#227;o pintadas com tinta <span class="elsevierStyleItalic">nankin</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">As margens laterais do esp&#233;cime s&#227;o seccionadas em quatro setores considerando o ponto fiducial de 12 horas identificado previamente pelo cirurgi&#227;o e em cortes considerando o sentido hor&#225;rio do esp&#233;cime conforme a seguir&#58; 12&#8208;3 horas&#44; 3&#8208;6 horas&#44; 6&#8208;9 horas e 9&#8208;12 horas &#40;m&#233;todo de orienta&#231;&#227;o &#8220;face do rel&#243;gio&#8221;&#41;&#46; Essas margens s&#227;o separadas da amostra com uma incis&#227;o com a ajuda de uma l&#226;mina cir&#250;rgica no ponto inicial &#40;p&#46; ex&#46;&#44; 12 horas&#41; e uma ressec&#231;&#227;o interna de 2&#44;0 a 3&#44;0<span class="elsevierStyleHsp" style=""></span>mm de espessura da pele paralela &#224; borda circunferencial&#46; Toda a extens&#227;o lateral daquele setor &#233; considerada para avalia&#231;&#227;o microsc&#243;pica&#46; A margem profunda &#233; analisada em corte paralelo&#44; tangencial &#224; face cruenta&#46; O procedimento est&#225; ilustrado na <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a>&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Os fragmentos representativos de cada margem s&#227;o ent&#227;o individual e sequencialmente submetidos para cortes de congela&#231;&#227;o por embebi&#231;&#227;o em meio de inclus&#227;o de congela&#231;&#227;o &#40;<span class="elsevierStyleItalic">tissue tek</span><span class="elsevierStyleItalic">&#174;</span>&#41; e congelamento a &#8722;30<span class="elsevierStyleHsp" style=""></span>&#176;C em cri&#243;tomo&#44; com a face da tinta &#40;ou face externa&#41; voltada para a face de corte do aparelho&#46; S&#227;o realizados cortes de 5&#44;0<span class="elsevierStyleHsp" style=""></span>&#956;m seguidos de colora&#231;&#227;o com hematoxilina e eosina&#44; montagem das l&#226;minas e avalia&#231;&#227;o pelo patologista&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">As margens s&#227;o laudadas pelo patologista separadamente de acordo com a identifica&#231;&#227;o dos setores como margem livre de neoplasia ou margem comprometida pela neoplasia&#46; Quando uma amostra do fragmento for positiva para c&#233;lulas tumorais ap&#243;s o exame histopatol&#243;gico&#44; uma amostra adicional de tecido&#44; na &#225;rea acometida pelo tumor&#44; ser&#225; retirada e enviada novamente para an&#225;lise do patologista&#46; O procedimento &#233; repetido at&#233; que margens livres de neoplasia sejam obtidas&#44; e assim o cirurgi&#227;o realiza a reconstru&#231;&#227;o da &#225;rea acometida ap&#243;s a retirada da les&#227;o&#46; Todas as amostras analisadas na congela&#231;&#227;o &#40;margens perif&#233;ricas e profunda&#41; s&#227;o submetidas a processamento histopatol&#243;gico convencional com confec&#231;&#227;o de blocos de parafina para confirmar o diagn&#243;stico do esp&#233;cime congelado no intraoperat&#243;rio&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Resultados</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados gerais</span><p id="par0085" class="elsevierStylePara elsevierViewall">Nosso estudo foi composto por 542 carcinomas cut&#226;neos&#44; excisados de 397 pacientes &#40;201 homens e 196 mulheres&#41;&#44; com idade m&#233;dia de 64 anos&#46; As caracter&#237;sticas cl&#237;nicas e de anatomia patol&#243;gica dos casos inclu&#237;dos no estudo est&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; O tamanho da les&#227;o por medi&#231;&#227;o da pe&#231;a patol&#243;gica &#40;cm&#41; foi em m&#233;dia 2&#44;0 &#215; 1&#44;4 &#215; 0&#44;56 &#40;di&#226;metro maior &#215; di&#226;metro menor &#215; espessura&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A topografia mais comum das les&#245;es ocorreu na regi&#227;o de cabe&#231;a e pesco&#231;o &#40;87&#44;8&#37;&#41;&#44; seguida por extremidades &#40;9&#44;4&#37;&#41; e tronco &#40;2&#44;8&#37;&#41;&#46; As les&#245;es acometendo as extremidades foram&#58; seis les&#245;es nas m&#227;os&#44; tr&#234;s les&#245;es nos p&#233;s&#44; cinco na regi&#227;o pr&#233;&#8208;tibial&#44; 13 nos membros superiores e 24 les&#245;es nos membros inferiores&#46; O CBC correspondeu a 79&#44;7&#37; dos casos&#44; e o CEC a 20&#44;3&#37;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">O seguimento m&#233;dio foi de 38 meses&#46; Em 53 casos tivemos perda de seguimento&#46; O tempo m&#225;ximo de seguimento foi de 74&#44;43 meses&#46; Os tipos de reconstru&#231;&#227;o ap&#243;s a ex&#233;rese cir&#250;rgica do carcinoma cut&#226;neo foram&#58; 454 retalho local &#40;83&#44;8&#37;&#41;&#44; 39 enxerto cut&#226;neo &#40;7&#44;2&#37;&#41;&#44; 34 fechamento prim&#225;rio &#40;6&#44;3&#37;&#41;&#44; 14 t&#233;cnica combinada &#40;2&#44;6&#37;&#41; e um microcir&#250;rgico &#40;0&#44;2&#37;&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Recorr&#234;ncia</span><p id="par0100" class="elsevierStylePara elsevierViewall">A recorr&#234;ncia tumoral total &#40;mediana de 38 meses&#41; foi de 1&#44;4&#37; &#8211; 0&#44;86&#37; para les&#245;es virgens de tratamento e 3&#44;7&#37; para les&#245;es secund&#225;rias&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Tamb&#233;m avaliamos as associa&#231;&#245;es entre as vari&#225;veis e a sobrevida livre de recorr&#234;ncia com a regress&#227;o COX&#44; mostrada na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Usando a regress&#227;o de COX m&#250;ltipla&#44; a associa&#231;&#227;o com a invas&#227;o perineural positiva apresentou um aumento de 13 vezes o risco de ter recidiva tumoral&#46; O n&#250;mero de amplia&#231;&#245;es de margens cir&#250;rgicas no intraoperat&#243;rio tamb&#233;m apresentou associa&#231;&#227;o&#44; com um aumento de 1&#44;8 vez o risco de recidiva tumoral para cada amplia&#231;&#227;o de margens&#46; Ent&#227;o&#44; quanto maior o n&#250;mero de amplia&#231;&#245;es de margens&#44; maior o risco de recidiva tumoral no futuro&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Dos sete casos recidivados&#44; quatro eram CBCs&#46; Desses&#44; tr&#234;s eram do subtipo histol&#243;gico misto &#40;mais de um subtipo histol&#243;gico&#41; e um CBC superficial&#44; todos localizados na face &#40;duas les&#245;es no couro cabeludo&#44; uma na fronte e uma no nariz&#41;&#44; tr&#234;s j&#225; eram tumores previamente recidivados &#40;subtipo histol&#243;gico misto&#41; e apresentaram margens comprometidas na primeira ressec&#231;&#227;o cir&#250;rgica &#8211; uma les&#227;o foi ampliada por at&#233; quatro vezes at&#233; atingir margens cir&#250;rgicas livres de tumor&#46; Os outros tr&#234;s casos recidivados eram CECs&#44; tamb&#233;m localizados na face &#40;orelha&#44; couro cabeludo e nariz&#41;&#44; todos les&#245;es virgens de tratamento&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Todos os pacientes que recidivaram tiveram um tempo m&#237;nimo de seguimento de quatro anos&#46; As recidivas ocorreram entre cinco e 44 meses ap&#243;s o procedimento cir&#250;rgico&#46; A sobrevida mediana livre de recidiva foi de 25 meses &#40;SD 5&#8208;44&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Revisamos as les&#245;es inclu&#237;das no estudo&#44; e 536 les&#245;es foram consideradas de alto risco&#46; A taxa de recidiva tumoral total nas les&#245;es de alto risco foi de 1&#44;3&#37; &#8211; 0&#44;87&#37; recidiva em tumor prim&#225;rio e 3&#44;7&#37; em tumor recorrente&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Rela&#231;&#227;o entre a congela&#231;&#227;o intraoperat&#243;ria &#8220;en face&#8221; e o resultado do processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina &#40;concordante ou discordante&#41;</span><p id="par0130" class="elsevierStylePara elsevierViewall">Os resultados do processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina estiveram de acordo com o resultado da congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; em 98&#37; das les&#245;es&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Avaliamos as associa&#231;&#245;es entre as vari&#225;veis do paciente e o resultado da patologia permanente &#40;parafina&#41; em rela&#231;&#227;o &#224; concord&#226;ncia com a congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46; As vari&#225;veis qualitativas descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> n&#227;o apresentaram signific&#226;ncia estat&#237;stica&#46; Por outro lado&#44; houve signific&#226;ncia estat&#237;stica em rela&#231;&#227;o &#224;s vari&#225;veis quantitativas&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Observou&#8208;se que existe uma rela&#231;&#227;o direta entre o n&#250;mero de les&#245;es operadas de um mesmo paciente e o aumento da discord&#226;ncia entre os m&#233;todos diagn&#243;sticos&#46; Cada les&#227;o operada em um mesmo paciente aumenta em 24&#37; o risco de discord&#226;ncia entre o resultado final do anatomopatol&#243;gico e a congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46; Em rela&#231;&#227;o &#224;s amplia&#231;&#245;es de margens&#44; para cada les&#227;o &#40;margem&#41; ampliada h&#225; um aumento de duas vezes no risco de haver discord&#226;ncia entre o resultado final do anatomopatol&#243;gico e a congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en</span><span class="elsevierStyleItalic">face</span>&#8221;&#46; Os resultados est&#227;o resumidos na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">Todas as vari&#225;veis com valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 foram inclu&#237;das na regress&#227;o log&#237;stica m&#250;ltipla &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discuss&#227;o</span><p id="par0150" class="elsevierStylePara elsevierViewall">Analisamos 397 pacientes&#44; com um total de 542 les&#245;es&#44; carcinomas cut&#226;neos &#40;CBC e CEC&#41;&#44; entre 1 de janeiro a 31 de dezembro de 2013 &#40;per&#237;odo de um ano&#41;&#44; em que foi realizado a congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46; Esse fato &#233; importante&#44; pois na literatura n&#227;o h&#225; estudos avaliando o uso da t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; com um n&#250;mero de casos similar em um per&#237;odo de tempo t&#227;o curto&#46; Na <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a> demonstramos de modo resumido algumas caracter&#237;sticas importantes de trabalhos encontrados na literatura sobre a congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0155" class="elsevierStylePara elsevierViewall">A maioria dos estudos encontrados na literatura sobre a t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; restrita a uma topografia espec&#237;fica&#44; descrevendo les&#245;es em regi&#227;o periorbital e na face&#44; mas nosso estudo teve um crit&#233;rio de inclus&#227;o mais amplo em rela&#231;&#227;o &#224; localiza&#231;&#227;o&#44; demonstrando que essa t&#233;cnica de congela&#231;&#227;o pode ser utilizada em outros s&#237;tios anat&#244;micos de maneira segura&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Tivemos uma taxa de 1&#44;4&#37; de recorr&#234;ncia tumoral total &#40;7&#47;542 les&#245;es&#41;&#46; Estratificando esse resultado&#44; houve uma taxa de 0&#44;86&#37; de recidiva para o tumor prim&#225;rio e 3&#44;7&#37; para o tumor recorrente&#44; com seguimento mediano superior a tr&#234;s anos&#46; Nenhum paciente que recorreu apresentou discord&#226;ncia entre o resultado da congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; intraoperat&#243;rio e o resultado final do exame anatomopatol&#243;gico &#40;exame de parafina&#41;&#44; demonstrando que essa t&#233;cnica de congela&#231;&#227;o &#233; segura e n&#227;o foi o fator determinante para a recorr&#234;ncia tumoral&#44; mais relacionada com a biologia do tumor&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5&#44;8</span></a> Nossa taxa de recorr&#234;ncia tumoral total se assemelha com a da literatura&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Com base em uma revis&#227;o da literatura&#44; a taxa de recorr&#234;ncia em cinco anos para CMM foi de 0&#44;6 a 3&#37; para CBC prim&#225;rio e 6 a 10&#37; para CBC recorrente&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> Montamos um fluxograma especificando os resultados separadamente de CBC e CEC quanto aos tumores prim&#225;rios&#44; recorrentes e ao &#237;ndice de recorr&#234;ncia &#40;<a class="elsevierStyleCrossRef" href="#fig0020">fig&#46; 4</a>&#41;&#46; Assim&#44; nossa taxa de recorr&#234;ncia para o CBC prim&#225;rio &#40;0&#44;3&#37;&#41; e o CBC recorrente &#40;4&#44;3&#37;&#41;&#44; com o uso da t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; &#233; semelhante aos resultados da CMM relatados na literatura&#46; Por&#233;m&#44; n&#227;o podemos comparar os resultados da congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; com a CMM&#44; pois n&#227;o h&#225; estudos na literatura comparando essas duas t&#233;cnicas&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0170" class="elsevierStylePara elsevierViewall">N&#227;o relatamos o tempo cir&#250;rgico encontrado com o uso da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; pois encontramos discord&#226;ncias entre anota&#231;&#245;es no prontu&#225;rio&#44; tornando os dados incertos&#46; Tullett et al&#46; relatam que o tempo para a prepara&#231;&#227;o das l&#226;minas na t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; de 45 a 75 minutos&#44; demonstrando que o uso dessa t&#233;cnica de congela&#231;&#227;o &#233; r&#225;pida&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Todas as margens perif&#233;ricas e profunda analisadas na congela&#231;&#227;o foram enviadas para an&#225;lise com a confec&#231;&#227;o de blocos de parafina&#44; afim de revisar as l&#226;minas da congela&#231;&#227;o de modo que o resultado seja seguro e assertivo que n&#227;o tenha havido tumor residual&#46; Na confec&#231;&#227;o de blocos de parafina&#44; as estruturas ficam mais evidentes e mais claras em virtude do corte histol&#243;gico mais fino&#44; possibilitando uma an&#225;lise mais detalhada&#46; Em 98&#37; dos casos tivemos o resultado da congela&#231;&#227;o intra&#8208;operat&#243;ria concordante com o resultado final do exame anatomopatol&#243;gico da pe&#231;a cir&#250;rgica &#40;exame de parafina&#41;&#46; Na experi&#234;ncia dos patologistas do nosso servi&#231;o&#44; essa discord&#226;ncia de interpreta&#231;&#227;o&#44; gerando o resultado da congela&#231;&#227;o falso&#8208;negativo&#44; &#233; comumente relacionada a cortes histol&#243;gicos espessos&#44; prolifera&#231;&#227;o inflamat&#243;ria&#44; prolifera&#231;&#227;o folicular e les&#245;es triquelimais&#46; Uma armadilha diagn&#243;stica comum na congela&#231;&#227;o de tumores cut&#226;neo &#233; confundir fol&#237;culos capilares seccionados tangencialmente em CBC&#46; A inflama&#231;&#227;o tamb&#233;m pode ser confundida com tumor ou pode obscurecer uma malignidade subjacente&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria padr&#227;o &#40;corte em &#8220;p&#227;o de forma&#8221;&#41; normalmente envolve se&#231;&#245;es por meio de amostras em seu eixo horizontal e longitudinal&#46; De acordo com a literatura&#44; aproximadamente 44&#37; de toda a margem &#233; normalmente examinada&#44; o que explica em parte por que os tumores inicialmente relatados como &#8220;completamente excisados&#8221; ocasionalmente recorrem&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">A t&#233;cnica de avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas por congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; descrita neste estudo oferece certos benef&#237;cios sobre as t&#233;cnicas de congela&#231;&#227;o padr&#227;o&#46; Um desses benef&#237;cios &#233; que essa t&#233;cnica examina todas as margens perif&#233;ricas e profunda&#44; evitando casos falso&#8208;negativos&#59; &#233; tamb&#233;m uma t&#233;cnica de r&#225;pida execu&#231;&#227;o e de f&#225;cil disponibilidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;7&#44;8&#44;13&#8211;15</span></a> Na <a class="elsevierStyleCrossRef" href="#fig0025">figura 5</a> demonstramos um desenho esquem&#225;tico da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; e da t&#233;cnica de congela&#231;&#227;o padr&#227;o&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0190" class="elsevierStylePara elsevierViewall">Podemos&#44; no entanto&#44; citar algumas limita&#231;&#245;es do uso da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#58; ela n&#227;o permite determinar a dist&#226;ncia entre o tumor e a margem final da pe&#231;a&#46; Mesmo que a margem seja negativa&#44; o tumor pode estar a apenas alguns micr&#244;metros de dist&#226;ncia&#46; Assim&#44; embora uma margem cl&#237;nica livre de 4<span class="elsevierStyleHsp" style=""></span>mm n&#227;o seja necess&#225;ria&#44; ainda &#233; preferido algum grau de margem cl&#237;nica livre ao utilizar a t&#233;cnica &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; para minimizar o risco de uma margem histol&#243;gica livre pequena&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;16&#44;17</span></a> De acordo com a literatura&#44; uma grande parte das recorr&#234;ncias tumorais ocorre ap&#243;s o quinto ano de tratamento&#46; Esse achado enfatiza a import&#226;ncia de um seguimento a longo prazo&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Esse fato demonstra um percal&#231;o em nosso estudo&#44; pois obtivemos um tempo de seguimento mediano de tr&#234;s anos&#46; No entanto&#44; nossos dados s&#227;o compar&#225;veis aos de outros estudos na literatura sobre uso de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">As les&#245;es em que houve discord&#226;ncia entre o resultado da congela&#231;&#227;o intraoperat&#243;ria e o resultado do processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina foram submetidas a tratamento complementar &#40;nova excis&#227;o cir&#250;rgica&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclus&#227;o</span><p id="par0200" class="elsevierStylePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; r&#225;pida&#44; segura e confi&#225;vel para garantir margens cir&#250;rgicas livres de tumor para CBC e CEC&#46; Nossa taxa de recorr&#234;ncia tumoral &#233; aceit&#225;vel&#44; de acordo com a literatura&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Suporte financeiro</span><p id="par0205" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Contribui&#231;&#227;o dos autores</span><p id="par0210" class="elsevierStylePara elsevierViewall">Ana Carolina Vasconcellos Guedes Otsuka&#58; Levantamento dos dados&#44; ou an&#225;lise e interpreta&#231;&#227;o dos dados&#59; Reda&#231;&#227;o do artigo ou revis&#227;o cr&#237;tica do conte&#250;do intelectual importante&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Eduardo Bertolli&#58; Concep&#231;&#227;o e o desenho do estudo&#44; an&#225;lise estat&#237;stica&#59; Reda&#231;&#227;o do artigo ou revis&#227;o cr&#237;tica do conte&#250;do intelectual importante&#59; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Mariana Petaccia de Macedo&#58; Concep&#231;&#227;o e o desenho do estudo&#59; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Clovis Antonio Lopes Pinto&#58; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; Aprova&#231;&#227;o final da vers&#227;o final do manuscrito&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Jo&#227;o Pedreira Duprat Neto&#58; Reda&#231;&#227;o do artigo ou revis&#227;o cr&#237;tica do conte&#250;do intelectual importante&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; aprova&#231;&#227;o final da vers&#227;o final do manuscrito&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflito de interesses</span><p id="par0235" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Os carcinomas cut&#226;neos dos tipos basocelular e espinocelular &#40;CBC e CEC&#41; s&#227;o os tipos mais comuns de c&#226;ncer no mundo&#46; A avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas por congela&#231;&#227;o vem sendo largamente utilizada para assegurar margens livres de doen&#231;a&#46; A t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; avalia todas as margens perif&#233;ricas e profunda&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Relatar os resultados da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; em rela&#231;&#227;o &#224; recorr&#234;ncia tumoral e &#224; concord&#226;ncia com o exame histopatol&#243;gico em parafina&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise retrospectiva dos pacientes submetidos &#224; ex&#233;rese cir&#250;rgica de CBC e CEC pelo N&#250;cleo de C&#226;ncer de Pele do A&#46;C&#46;Camargo Cancer Center&#44; Brasil&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nosso estudo incluiu 542 carcinomas de pele&#44; que foram excisados de 397 pacientes &#8211; 201 do sexo masculino &#40;50&#44;6&#37;&#41;&#44; 196 do sexo feminino &#40;49&#44;4&#37;&#41;&#44; com idade m&#233;dia de 64 anos&#46; Os tumores foram localizados em sua maioria na regi&#227;o da cabe&#231;a e pesco&#231;o &#40;87&#44;8&#37;&#41;&#46; O CBC correspondeu a 79&#44;7&#37; dos casos&#46; O seguimento m&#233;dio foi de 38 meses&#46; A recidiva tumoral ocorreu em 0&#44;86&#37; para os tumores prim&#225;rios e 3&#44;7&#37; para os tumores recorrentes&#46; O resultado da congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; foi concordante com o resultado final do exame anatomopatol&#243;gico &#40;exame em parafina&#41; em 98&#37; das les&#245;es&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">N&#227;o ter o tempo de seguimento m&#237;nimo de cinco anos em todos os pacientes&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; uma t&#233;cnica com baixa recidiva tumoral&#44; confi&#225;vel e segura para garantir margens cir&#250;rgicas negativas de tumor&#46;</p></span>"
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;vel&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Fronte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">10&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Nariz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">199&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">36&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">L&#225;bio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regi&#227;o malar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regi&#227;o temporal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regi&#227;o retroauricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Orelha&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">P&#225;lpebra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regi&#227;o cervical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tronco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dorso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Flanco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Membros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subtipos histol&#243;gicos de carcinoma cut&#226;neo basocelular</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Superficial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Esclerodermiforme&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Micronodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Misto<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">159&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outros<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de anestesia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Local exclusiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Local e seda&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Geral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">329&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bloqueio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apresenta&#231;&#227;o inicial da les&#227;o</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Virgem de tratamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">463&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tumor recidivado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Invas&#227;o perineural</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ausente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">533&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resultado primeira congela&#231;&#227;o</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Margens livres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">392&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Margens comprometidas<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">511&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamento complementar &#40;ap&#243;s a cirurgia&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Radioterapia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cirurgia complementar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamento t&#243;pico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Mais de um subtipo histol&#243;gico&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Outros subtipos de CBC&#58; adenoide e basoescamoso&#46;</p>"
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            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Em 116 les&#245;es foi necess&#225;ria uma amplia&#231;&#227;o de margem cir&#250;rgica no intraoperat&#243;rio para obter margens livres de tumor&#46; Em 20 les&#245;es&#44; foram necess&#225;rias duas amplia&#231;&#245;es&#46; Em 11 les&#245;es&#44; foram necess&#225;rias tr&#234;s amplia&#231;&#245;es&#46; Em duas les&#245;es&#44; foram necess&#225;rias quatro amplia&#231;&#245;es&#59; e em uma les&#227;o&#44; foram necess&#225;rios seis amplia&#231;&#245;es de margens cir&#250;rgicas para obter margens livres&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas qualitativas dos pacientes submetidos &#224; ex&#233;rese de carcinomas cut&#226;neos basocelular &#40;CBC&#41; e espinocelular &#40;CEC&#41;&#44; no ano de 2013&#44; de janeiro a dezembro no A&#46;C&#46;Camargo Cancer Center</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">RR&#44; risco relativo&#59; 95&#37; IC&#44; intervalo de confian&#231;a&#59; CBC&#44; carcinoma basocelular&#59; CEC&#44; carcinoma espinocelular&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Vari&#225;vel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o de COX simples</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o de COX m&#250;ltipla</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Invas&#227;o perineural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;507&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;023&#8208;70&#46;758&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;504&#8208;113&#46;216&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de amplia&#231;&#245;es at&#233; obter margens livres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;841&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;170&#8208;2&#46;895&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;872&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;205&#8208;2&#46;907&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Regress&#227;o de Cox simples e m&#250;ltipla com vari&#225;veis associadas &#224; sobrevida livre de recorr&#234;ncia em pacientes submetidos a ex&#233;rese de CBC e CEC&#44; no ano de 2013&#44; de janeiro a dezembro no A&#46;C&#46;Camargo Cancer Center</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">OR&#44; odds ratio&#59; 95&#37; IC&#44; intervalo de confian&#231;a&#59; CBC&#44; carcinoma basocelular&#59; CEC&#44; carcinoma espinocelular&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Vari&#225;vel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o log&#237;stica simples</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o log&#237;stica m&#250;ltipla</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de les&#245;es operadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;227&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;089&#8208;1&#46;383&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;243&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;101&#8208;1&#46;403&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de amplia&#231;&#245;es at&#233; margens livres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;945&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;231&#8208;3&#46;073&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;035&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;237&#8208;3&#46;347&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Regress&#227;o log&#237;stica simples e m&#250;ltipla com vari&#225;veis associadas ao resultado final do anatomopatol&#243;gico &#40;concordante e discordante&#41; em pacientes submetidos a ex&#233;rese de CBC e CEC&#44; no ano de 2013&#44; de janeiro a dezembro no A&#46;C&#46;Camargo Cancer Center</p>"
        ]
      ]
      8 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">CBC&#44; carcinoma basocelular&#59; CEC&#44; carcinoma espinocelular&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Per&#237;odo estudado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero de les&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Localiza&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Seguimento &#40;meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Taxa de recorr&#234;ncia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gayre et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1985 a 2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1638&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1992 a 2001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">534&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;2&#37;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gill et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1997 a 2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resti et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1998 a 2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC palpebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kvannli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1999 a 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">262&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC e CEC periorbitais&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Menesi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2002 a 2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC na face&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tullett et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2003 a 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nizamoglu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2010 a 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinomas de alto risco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presente estudo<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC e CEC cabe&#231;a e pesco&#231;o&#44; tronco e membros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Les&#227;o prim&#225;ria&#46;</p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Estudo atual&#46;</p>"
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Dados encontrados na literatura sobre o uso da congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;</p>"
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      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:17 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of worldwide incidence of nonmelanoma skin cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Lomas"
                            1 => "J&#46; Leonardi-Bee"
                            2 => "F&#46; Bath-Hextall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2012.10830.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2012"
                        "volumen" => "166"
                        "paginaInicial" => "1069"
                        "paginaFinal" => "1080"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22251204"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "nccn&#46;org &#91;Internet&#93;&#46; Pensilv&#226;nia&#58; National Comprehensive Cancer Network&#59; c2022&#46; NCCN Clinical Practice Guidelines in Oncology &#40;NCCN Guidelines&#41; Basal cell skin cancer &#40;2020&#41;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "inca&#46;gov &#91;Internet&#93;&#46; Minist&#233;rio da Sa&#250;de&#46; Instituto Nacional de C&#226;ncer Jos&#233; Alencar Gomes da Silva&#46; Estimativa 2020&#58; Incid&#234;ncia de c&#226;ncer no Brasil&#46; Rio de Janeiro&#58; INCA&#59; 2019&#46; Dispon&#237;vel em&#58; https&#58;&#47;&#47;www&#46;inca&#46;gov&#46;br&#47;sites&#47;ufu&#46;sti&#46;inca&#46;local&#47;files&#47;media&#47;document&#47;estimativa&#8208;2020&#8208;incidencia&#8208;de&#8208;cancer&#8208;no&#8208;brasil&#46;pdf&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of periocular basal cell carcinoma with modified en face frozen section controlled excision"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46;A&#46; Wong"
                            1 => "J&#46;A&#46; Marshall"
                            2 => "K&#46;J&#46; Whitehead"
                            3 => "R&#46;M&#46; Williamson"
                            4 => "T&#46;J&#46; Sullivan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00002341-200211000-00008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthal Plast Reconstr Surg&#46;"
                        "fecha" => "2002"
                        "volumen" => "18"
                        "paginaInicial" => "430"
                        "paginaFinal" => "435"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12439056"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A reliable frozen section technique for basal cell carcinomas of the head and neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46; Menesi"
                            1 => "E&#46;W&#46; Buchel"
                            2 => "T&#46; Je"
                            3 => "H&#46; Md"
                            4 => "T&#46;J&#46; Hayakawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Plast Surg&#46;"
                        "fecha" => "2014"
                        "volumen" => "22"
                        "paginaInicial" => "179"
                        "paginaFinal" => "182"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
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              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acur&#225;cia da bi&#243;psia de congela&#231;&#227;o no c&#226;ncer de pele n&#227;o&#8208;melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;M&#46; Kiyan"
                            1 => "J&#46; Broetto"
                            2 => "R&#46; Fischler"
                            3 => "A&#46;E&#46; Sperli"
                            4 => "J&#46;O&#46;G&#46; Freitas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Bras Cir Pl&#225;st&#46;"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "472"
                        "paginaFinal" => "474"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Excision of periocular basal cell carcinoma guided by en face frozen section"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Tullett"
                            1 => "S&#46; Sagili"
                            2 => "A&#46; Barrett"
                            3 => "R&#46; Malhotra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bjoms.2012.10.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Oral Maxillofac Surg&#46;"
                        "fecha" => "2013"
                        "volumen" => "51"
                        "paginaInicial" => "520"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23219018"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frozen section of skin specimens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;J&#46; Smith-Zagone"
                            1 => "M&#46;R&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5858/2005-129-1536-FSOSS"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Pathol Lab Med&#46;"
                        "fecha" => "2005"
                        "volumen" => "129"
                        "paginaInicial" => "1536"
                        "paginaFinal" => "1543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16329726"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Using frozen section margin control technique to manage non&#8208;melanomatous skin lesions in high&#8208;risk sites"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Nizamoglu"
                            1 => "H&#46; Douglas"
                            2 => "C&#46; McArdle"
                            3 => "B&#46; Mathew"
                            4 => "C&#46; Vize"
                            5 => "P&#46; Matteucci"
                          ]
                        ]
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Artigo original
O uso da técnica de avaliação intraoperatória de margens cirúrgicas por congelação “en face” no manejo de carcinomas cutâneos: resultados oncológicos de uma única instituição
Ana Carolina Vasconcellos Guedes Otsukaa,
Corresponding author
ac.otsuka@gmail.com

Autor para correspondência.
, Eduardo Bertollib, Mariana Petaccia de Macedoc, Clovis Antonio Lopes Pintod, João Pedreira Duprat Netob
a Cirurgia Plástica, A.C.Camargo Cancer Center, São Paulo, SP, Brasil
b Departamento da Oncologia Cutânea, A.C.Camargo Cancer Center, São Paulo, SP, Brasil
c Departamento de Patologia, Hospital Sírio Libanês, São Paulo, SP, Brasil
d Departamento de Patologia, A.C.Camargo Cancer Center, São Paulo, SP, Brasil
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">Os c&#226;nceres de pele carcinoma cut&#226;neo basocelular &#40;CBC&#41; e carcinoma cut&#226;neo espinocelular &#40;CEC&#41; s&#227;o mais prevalentes que todos os outros tipos de c&#226;ncer combinados&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> No Brasil correspondem a 30&#37; de todos os tumores malignos registrados no pa&#237;s&#46; Conforme dados do Instituto Nacional de C&#226;ncer &#40;INCA&#41;&#44; estima&#8208;se 176&#46;930 novos casos em 2020 &#8211; 83&#46;770 em homens e 93&#46;160 em mulheres&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">De acordo com o National Comprehensive Cancer Network &#40;NCCN&#41; Guidelines&#44; o principal objetivo do tratamento do CBC e CEC &#233; a remo&#231;&#227;o cir&#250;rgica completa do tumor e a preserva&#231;&#227;o m&#225;xima da fun&#231;&#227;o e cosm&#233;tica&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A ex&#233;rese com margem cir&#250;rgica ampla pode ocasionar desfiguramento e cicatrizes desnecess&#225;rias&#44; enquanto as ressec&#231;&#245;es conservadoras podem resultar na remo&#231;&#227;o incompleta do tumor e maior recorr&#234;ncia local&#44; especialmente em les&#245;es com alto risco de recorr&#234;ncia&#46; As caracter&#237;sticas de alto risco de CBC e CEC s&#227;o&#58; profundidade de invas&#227;o &#40;&#62; 6<span class="elsevierStyleHsp" style=""></span>mm ou invas&#227;o al&#233;m do subcut&#226;neo para CEC&#41;&#44; grau de diferencia&#231;&#227;o histol&#243;gica pouco diferenciado&#44; localiza&#231;&#227;o anat&#244;mica de alto risco &#40;face&#44; orelha&#44; pr&#233;&#47;p&#243;s&#8208;auricular&#44; genit&#225;lia&#44; m&#227;os e p&#233;s&#41;&#44; envolvimento perineural&#44; les&#245;es recorrentes ap&#243;s cirurgia e&#47;ou radioterapia&#44; imunossupress&#227;o e bordas mal definidas&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas da les&#227;o por exame de congela&#231;&#227;o vem sendo largamente utilizada para tentar assegurar margens livres de doen&#231;a&#44; e &#233; mais seguro em planejar a reconstru&#231;&#227;o definitiva&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> A cirurgia microgr&#225;fica de Mohs &#40;CMM&#41; &#233; uma das t&#233;cnicas propostas para CBC e CEC de alto risco&#44; pois propicia a an&#225;lise intraoperat&#243;ria de 100&#37; da margem de excis&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Por&#233;m&#44; &#233; importante haver uma alternativa aceit&#225;vel e segura para suprir a CMM&#44; pois essa t&#233;cnica pode ser financeiramente invi&#225;vel e limitada em sua disponibilidade&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Outra t&#233;cnica em que tamb&#233;m h&#225; uma avalia&#231;&#227;o completa de todas as margens &#233; a avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas por congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; uma poss&#237;vel alternativa &#224; CMM&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">O termo &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; uma express&#227;o usada para se referir que ao examinar a pe&#231;a cir&#250;rgica durante a congela&#231;&#227;o intraoperat&#243;ria&#44; as se&#231;&#245;es de margens analisadas s&#227;o processadas paralelo &#224; margem cir&#250;rgica&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Nosso objetivo &#233; relatar os resultados da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; quanto &#224; recorr&#234;ncia do tumor e a concord&#226;ncia com os cortes de parafina&#44; na rotina de uma institui&#231;&#227;o&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material e m&#233;todos</span><p id="par0035" class="elsevierStylePara elsevierViewall">An&#225;lise retrospectiva de pacientes submetidos &#224; ex&#233;rese cir&#250;rgica de CBC e CEC pelo N&#250;cleo de C&#226;ncer de Pele do A&#46;C&#46;Camargo Cancer Center&#44; S&#227;o Paulo&#47;SP &#8211; Brasil&#44; entre janeiro a dezembro de 2013&#46; Houve aprova&#231;&#227;o do Comit&#234; de &#201;tica em pesquisa local para estse estudo&#44; n&#176; 2602&#47;18&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Pacientes</span><p id="par0040" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos no estudo pacientes com CBC e&#47;ou CEC&#44; prim&#225;rio ou recorrente&#44; submetidos &#224; t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; independente da topografia da les&#227;o&#46; Os crit&#233;rios de n&#227;o inclus&#227;o foram pacientes com outros tipos de neoplasia cut&#226;neas e pacientes que n&#227;o realizaram a t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Foram avaliados os seguintes dados cl&#237;nicos&#44; epidemiol&#243;gicos&#44; de anatomia patol&#243;gica e tratamento de cada paciente&#58; sexo&#44; idade&#44; tipo e subtipo de tumor&#44; tipo de reconstru&#231;&#227;o&#44; n&#250;mero de ressec&#231;&#245;es necess&#225;rias para obter margens cir&#250;rgicas livre de tumor&#44; o resultado do exame intraoperat&#243;rio de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; e resultado final do anatomopatol&#243;gico ap&#243;s processamento histopatol&#243;gico convencional com confec&#231;&#227;o de blocos de parafina&#44; necessidade de tratamento complementar&#44; tempo de seguimento e recorr&#234;ncia tumoral &#40;a recorr&#234;ncia foi definida como o reaparecimento da les&#227;o no acompanhamento cl&#237;nico confirmado por exame histol&#243;gico&#41;&#46; As les&#245;es prim&#225;rias foram consideradas CBCs ou CECs rec&#233;m&#8208;diagnosticados clinicamente&#44; e as les&#245;es secund&#225;rias foram aquelas que haviam sido tratadas anteriormente em outros hospitais e recorreram&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">An&#225;lise estat&#237;stica</span><p id="par0050" class="elsevierStylePara elsevierViewall">A an&#225;lise descritiva foi realizada com a avalia&#231;&#227;o dos prontu&#225;rios&#46; Regress&#245;es log&#237;sticas simples foram utilizadas para identificar vari&#225;veis que se associaram aos desfechos estudados&#46; Todas as vari&#225;veis com valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 foram inclu&#237;das nos modelos de regress&#227;o log&#237;stica m&#250;ltipla&#46; O software IBM SPSS v 20&#46;0&#174; foi utilizado para a an&#225;lise estat&#237;stica&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">T&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;en face&#8221;</span><p id="par0055" class="elsevierStylePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; propicia o exame de todas as margens do tumor&#46; Todas as margens perif&#233;ricas e profunda da pe&#231;a analisada na congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; foram enviadas para processamento histopatol&#243;gico convencional com confec&#231;&#227;o de blocos de parafina&#46; Assim&#44; foram comparados os resultados do exame intraoperat&#243;rio da congela&#231;&#227;o com o resultado final anatomopatol&#243;gico ap&#243;s processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">O procedimento cir&#250;rgico foi realizado da seguinte maneira&#58; as margens de ressec&#231;&#227;o do tumor cut&#226;neo foram demarcadas com aux&#237;lio de dermatosc&#243;pio manual utilizado pelo cirurgi&#227;o respons&#225;vel pelo procedimento&#44; com o objetivo de alcan&#231;ar margens de ressec&#231;&#227;o livres&#46; N&#227;o foi poss&#237;vel documentar a margem cir&#250;rgica utilizada para a excis&#227;o&#44; por se tratar de um estudo retrospectivo&#46; A excis&#227;o foi realizada sob anestesia geral&#44; anestesia local associada com seda&#231;&#227;o&#44; anestesia local pura ou raquianestesia associada a seda&#231;&#227;o&#44; dependendo das comorbidades do paciente&#44; do planejamento da reconstru&#231;&#227;o e do tamanho da les&#227;o&#46; A excis&#227;o da les&#227;o foi realizada com a borda circunferencial reta e a margem profunda plana&#44; diferindo da forma angulada da ressec&#231;&#227;o CMM&#46; Na <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> demonstramos o aspecto cl&#237;nico da les&#227;o antes da excis&#227;o com delimita&#231;&#227;o dermatosc&#243;pica das margens cir&#250;rgicas&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">O exame intraoperat&#243;rio para avalia&#231;&#227;o de margens cir&#250;rgicas da les&#227;o excisada se inicia com o recebimento pelo patologista do esp&#233;cime a fresco com identifica&#231;&#227;o pr&#233;via pelo cirurgi&#227;o do ponto de refer&#234;ncia do paciente de 12 horas&#46; Todas as margens laterais e profunda do esp&#233;cime s&#227;o ent&#227;o pintadas com tinta <span class="elsevierStyleItalic">nankin</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">As margens laterais do esp&#233;cime s&#227;o seccionadas em quatro setores considerando o ponto fiducial de 12 horas identificado previamente pelo cirurgi&#227;o e em cortes considerando o sentido hor&#225;rio do esp&#233;cime conforme a seguir&#58; 12&#8208;3 horas&#44; 3&#8208;6 horas&#44; 6&#8208;9 horas e 9&#8208;12 horas &#40;m&#233;todo de orienta&#231;&#227;o &#8220;face do rel&#243;gio&#8221;&#41;&#46; Essas margens s&#227;o separadas da amostra com uma incis&#227;o com a ajuda de uma l&#226;mina cir&#250;rgica no ponto inicial &#40;p&#46; ex&#46;&#44; 12 horas&#41; e uma ressec&#231;&#227;o interna de 2&#44;0 a 3&#44;0<span class="elsevierStyleHsp" style=""></span>mm de espessura da pele paralela &#224; borda circunferencial&#46; Toda a extens&#227;o lateral daquele setor &#233; considerada para avalia&#231;&#227;o microsc&#243;pica&#46; A margem profunda &#233; analisada em corte paralelo&#44; tangencial &#224; face cruenta&#46; O procedimento est&#225; ilustrado na <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a>&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Os fragmentos representativos de cada margem s&#227;o ent&#227;o individual e sequencialmente submetidos para cortes de congela&#231;&#227;o por embebi&#231;&#227;o em meio de inclus&#227;o de congela&#231;&#227;o &#40;<span class="elsevierStyleItalic">tissue tek</span><span class="elsevierStyleItalic">&#174;</span>&#41; e congelamento a &#8722;30<span class="elsevierStyleHsp" style=""></span>&#176;C em cri&#243;tomo&#44; com a face da tinta &#40;ou face externa&#41; voltada para a face de corte do aparelho&#46; S&#227;o realizados cortes de 5&#44;0<span class="elsevierStyleHsp" style=""></span>&#956;m seguidos de colora&#231;&#227;o com hematoxilina e eosina&#44; montagem das l&#226;minas e avalia&#231;&#227;o pelo patologista&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">As margens s&#227;o laudadas pelo patologista separadamente de acordo com a identifica&#231;&#227;o dos setores como margem livre de neoplasia ou margem comprometida pela neoplasia&#46; Quando uma amostra do fragmento for positiva para c&#233;lulas tumorais ap&#243;s o exame histopatol&#243;gico&#44; uma amostra adicional de tecido&#44; na &#225;rea acometida pelo tumor&#44; ser&#225; retirada e enviada novamente para an&#225;lise do patologista&#46; O procedimento &#233; repetido at&#233; que margens livres de neoplasia sejam obtidas&#44; e assim o cirurgi&#227;o realiza a reconstru&#231;&#227;o da &#225;rea acometida ap&#243;s a retirada da les&#227;o&#46; Todas as amostras analisadas na congela&#231;&#227;o &#40;margens perif&#233;ricas e profunda&#41; s&#227;o submetidas a processamento histopatol&#243;gico convencional com confec&#231;&#227;o de blocos de parafina para confirmar o diagn&#243;stico do esp&#233;cime congelado no intraoperat&#243;rio&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Resultados</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados gerais</span><p id="par0085" class="elsevierStylePara elsevierViewall">Nosso estudo foi composto por 542 carcinomas cut&#226;neos&#44; excisados de 397 pacientes &#40;201 homens e 196 mulheres&#41;&#44; com idade m&#233;dia de 64 anos&#46; As caracter&#237;sticas cl&#237;nicas e de anatomia patol&#243;gica dos casos inclu&#237;dos no estudo est&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; O tamanho da les&#227;o por medi&#231;&#227;o da pe&#231;a patol&#243;gica &#40;cm&#41; foi em m&#233;dia 2&#44;0 &#215; 1&#44;4 &#215; 0&#44;56 &#40;di&#226;metro maior &#215; di&#226;metro menor &#215; espessura&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A topografia mais comum das les&#245;es ocorreu na regi&#227;o de cabe&#231;a e pesco&#231;o &#40;87&#44;8&#37;&#41;&#44; seguida por extremidades &#40;9&#44;4&#37;&#41; e tronco &#40;2&#44;8&#37;&#41;&#46; As les&#245;es acometendo as extremidades foram&#58; seis les&#245;es nas m&#227;os&#44; tr&#234;s les&#245;es nos p&#233;s&#44; cinco na regi&#227;o pr&#233;&#8208;tibial&#44; 13 nos membros superiores e 24 les&#245;es nos membros inferiores&#46; O CBC correspondeu a 79&#44;7&#37; dos casos&#44; e o CEC a 20&#44;3&#37;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">O seguimento m&#233;dio foi de 38 meses&#46; Em 53 casos tivemos perda de seguimento&#46; O tempo m&#225;ximo de seguimento foi de 74&#44;43 meses&#46; Os tipos de reconstru&#231;&#227;o ap&#243;s a ex&#233;rese cir&#250;rgica do carcinoma cut&#226;neo foram&#58; 454 retalho local &#40;83&#44;8&#37;&#41;&#44; 39 enxerto cut&#226;neo &#40;7&#44;2&#37;&#41;&#44; 34 fechamento prim&#225;rio &#40;6&#44;3&#37;&#41;&#44; 14 t&#233;cnica combinada &#40;2&#44;6&#37;&#41; e um microcir&#250;rgico &#40;0&#44;2&#37;&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Recorr&#234;ncia</span><p id="par0100" class="elsevierStylePara elsevierViewall">A recorr&#234;ncia tumoral total &#40;mediana de 38 meses&#41; foi de 1&#44;4&#37; &#8211; 0&#44;86&#37; para les&#245;es virgens de tratamento e 3&#44;7&#37; para les&#245;es secund&#225;rias&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Tamb&#233;m avaliamos as associa&#231;&#245;es entre as vari&#225;veis e a sobrevida livre de recorr&#234;ncia com a regress&#227;o COX&#44; mostrada na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Usando a regress&#227;o de COX m&#250;ltipla&#44; a associa&#231;&#227;o com a invas&#227;o perineural positiva apresentou um aumento de 13 vezes o risco de ter recidiva tumoral&#46; O n&#250;mero de amplia&#231;&#245;es de margens cir&#250;rgicas no intraoperat&#243;rio tamb&#233;m apresentou associa&#231;&#227;o&#44; com um aumento de 1&#44;8 vez o risco de recidiva tumoral para cada amplia&#231;&#227;o de margens&#46; Ent&#227;o&#44; quanto maior o n&#250;mero de amplia&#231;&#245;es de margens&#44; maior o risco de recidiva tumoral no futuro&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Dos sete casos recidivados&#44; quatro eram CBCs&#46; Desses&#44; tr&#234;s eram do subtipo histol&#243;gico misto &#40;mais de um subtipo histol&#243;gico&#41; e um CBC superficial&#44; todos localizados na face &#40;duas les&#245;es no couro cabeludo&#44; uma na fronte e uma no nariz&#41;&#44; tr&#234;s j&#225; eram tumores previamente recidivados &#40;subtipo histol&#243;gico misto&#41; e apresentaram margens comprometidas na primeira ressec&#231;&#227;o cir&#250;rgica &#8211; uma les&#227;o foi ampliada por at&#233; quatro vezes at&#233; atingir margens cir&#250;rgicas livres de tumor&#46; Os outros tr&#234;s casos recidivados eram CECs&#44; tamb&#233;m localizados na face &#40;orelha&#44; couro cabeludo e nariz&#41;&#44; todos les&#245;es virgens de tratamento&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Todos os pacientes que recidivaram tiveram um tempo m&#237;nimo de seguimento de quatro anos&#46; As recidivas ocorreram entre cinco e 44 meses ap&#243;s o procedimento cir&#250;rgico&#46; A sobrevida mediana livre de recidiva foi de 25 meses &#40;SD 5&#8208;44&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Revisamos as les&#245;es inclu&#237;das no estudo&#44; e 536 les&#245;es foram consideradas de alto risco&#46; A taxa de recidiva tumoral total nas les&#245;es de alto risco foi de 1&#44;3&#37; &#8211; 0&#44;87&#37; recidiva em tumor prim&#225;rio e 3&#44;7&#37; em tumor recorrente&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Rela&#231;&#227;o entre a congela&#231;&#227;o intraoperat&#243;ria &#8220;en face&#8221; e o resultado do processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina &#40;concordante ou discordante&#41;</span><p id="par0130" class="elsevierStylePara elsevierViewall">Os resultados do processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina estiveram de acordo com o resultado da congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; em 98&#37; das les&#245;es&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Avaliamos as associa&#231;&#245;es entre as vari&#225;veis do paciente e o resultado da patologia permanente &#40;parafina&#41; em rela&#231;&#227;o &#224; concord&#226;ncia com a congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46; As vari&#225;veis qualitativas descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> n&#227;o apresentaram signific&#226;ncia estat&#237;stica&#46; Por outro lado&#44; houve signific&#226;ncia estat&#237;stica em rela&#231;&#227;o &#224;s vari&#225;veis quantitativas&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Observou&#8208;se que existe uma rela&#231;&#227;o direta entre o n&#250;mero de les&#245;es operadas de um mesmo paciente e o aumento da discord&#226;ncia entre os m&#233;todos diagn&#243;sticos&#46; Cada les&#227;o operada em um mesmo paciente aumenta em 24&#37; o risco de discord&#226;ncia entre o resultado final do anatomopatol&#243;gico e a congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46; Em rela&#231;&#227;o &#224;s amplia&#231;&#245;es de margens&#44; para cada les&#227;o &#40;margem&#41; ampliada h&#225; um aumento de duas vezes no risco de haver discord&#226;ncia entre o resultado final do anatomopatol&#243;gico e a congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en</span><span class="elsevierStyleItalic">face</span>&#8221;&#46; Os resultados est&#227;o resumidos na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">Todas as vari&#225;veis com valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 foram inclu&#237;das na regress&#227;o log&#237;stica m&#250;ltipla &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discuss&#227;o</span><p id="par0150" class="elsevierStylePara elsevierViewall">Analisamos 397 pacientes&#44; com um total de 542 les&#245;es&#44; carcinomas cut&#226;neos &#40;CBC e CEC&#41;&#44; entre 1 de janeiro a 31 de dezembro de 2013 &#40;per&#237;odo de um ano&#41;&#44; em que foi realizado a congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46; Esse fato &#233; importante&#44; pois na literatura n&#227;o h&#225; estudos avaliando o uso da t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; com um n&#250;mero de casos similar em um per&#237;odo de tempo t&#227;o curto&#46; Na <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a> demonstramos de modo resumido algumas caracter&#237;sticas importantes de trabalhos encontrados na literatura sobre a congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0155" class="elsevierStylePara elsevierViewall">A maioria dos estudos encontrados na literatura sobre a t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; restrita a uma topografia espec&#237;fica&#44; descrevendo les&#245;es em regi&#227;o periorbital e na face&#44; mas nosso estudo teve um crit&#233;rio de inclus&#227;o mais amplo em rela&#231;&#227;o &#224; localiza&#231;&#227;o&#44; demonstrando que essa t&#233;cnica de congela&#231;&#227;o pode ser utilizada em outros s&#237;tios anat&#244;micos de maneira segura&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Tivemos uma taxa de 1&#44;4&#37; de recorr&#234;ncia tumoral total &#40;7&#47;542 les&#245;es&#41;&#46; Estratificando esse resultado&#44; houve uma taxa de 0&#44;86&#37; de recidiva para o tumor prim&#225;rio e 3&#44;7&#37; para o tumor recorrente&#44; com seguimento mediano superior a tr&#234;s anos&#46; Nenhum paciente que recorreu apresentou discord&#226;ncia entre o resultado da congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; intraoperat&#243;rio e o resultado final do exame anatomopatol&#243;gico &#40;exame de parafina&#41;&#44; demonstrando que essa t&#233;cnica de congela&#231;&#227;o &#233; segura e n&#227;o foi o fator determinante para a recorr&#234;ncia tumoral&#44; mais relacionada com a biologia do tumor&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5&#44;8</span></a> Nossa taxa de recorr&#234;ncia tumoral total se assemelha com a da literatura&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Com base em uma revis&#227;o da literatura&#44; a taxa de recorr&#234;ncia em cinco anos para CMM foi de 0&#44;6 a 3&#37; para CBC prim&#225;rio e 6 a 10&#37; para CBC recorrente&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> Montamos um fluxograma especificando os resultados separadamente de CBC e CEC quanto aos tumores prim&#225;rios&#44; recorrentes e ao &#237;ndice de recorr&#234;ncia &#40;<a class="elsevierStyleCrossRef" href="#fig0020">fig&#46; 4</a>&#41;&#46; Assim&#44; nossa taxa de recorr&#234;ncia para o CBC prim&#225;rio &#40;0&#44;3&#37;&#41; e o CBC recorrente &#40;4&#44;3&#37;&#41;&#44; com o uso da t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; &#233; semelhante aos resultados da CMM relatados na literatura&#46; Por&#233;m&#44; n&#227;o podemos comparar os resultados da congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; com a CMM&#44; pois n&#227;o h&#225; estudos na literatura comparando essas duas t&#233;cnicas&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0170" class="elsevierStylePara elsevierViewall">N&#227;o relatamos o tempo cir&#250;rgico encontrado com o uso da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#44; pois encontramos discord&#226;ncias entre anota&#231;&#245;es no prontu&#225;rio&#44; tornando os dados incertos&#46; Tullett et al&#46; relatam que o tempo para a prepara&#231;&#227;o das l&#226;minas na t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; de 45 a 75 minutos&#44; demonstrando que o uso dessa t&#233;cnica de congela&#231;&#227;o &#233; r&#225;pida&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Todas as margens perif&#233;ricas e profunda analisadas na congela&#231;&#227;o foram enviadas para an&#225;lise com a confec&#231;&#227;o de blocos de parafina&#44; afim de revisar as l&#226;minas da congela&#231;&#227;o de modo que o resultado seja seguro e assertivo que n&#227;o tenha havido tumor residual&#46; Na confec&#231;&#227;o de blocos de parafina&#44; as estruturas ficam mais evidentes e mais claras em virtude do corte histol&#243;gico mais fino&#44; possibilitando uma an&#225;lise mais detalhada&#46; Em 98&#37; dos casos tivemos o resultado da congela&#231;&#227;o intra&#8208;operat&#243;ria concordante com o resultado final do exame anatomopatol&#243;gico da pe&#231;a cir&#250;rgica &#40;exame de parafina&#41;&#46; Na experi&#234;ncia dos patologistas do nosso servi&#231;o&#44; essa discord&#226;ncia de interpreta&#231;&#227;o&#44; gerando o resultado da congela&#231;&#227;o falso&#8208;negativo&#44; &#233; comumente relacionada a cortes histol&#243;gicos espessos&#44; prolifera&#231;&#227;o inflamat&#243;ria&#44; prolifera&#231;&#227;o folicular e les&#245;es triquelimais&#46; Uma armadilha diagn&#243;stica comum na congela&#231;&#227;o de tumores cut&#226;neo &#233; confundir fol&#237;culos capilares seccionados tangencialmente em CBC&#46; A inflama&#231;&#227;o tamb&#233;m pode ser confundida com tumor ou pode obscurecer uma malignidade subjacente&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria padr&#227;o &#40;corte em &#8220;p&#227;o de forma&#8221;&#41; normalmente envolve se&#231;&#245;es por meio de amostras em seu eixo horizontal e longitudinal&#46; De acordo com a literatura&#44; aproximadamente 44&#37; de toda a margem &#233; normalmente examinada&#44; o que explica em parte por que os tumores inicialmente relatados como &#8220;completamente excisados&#8221; ocasionalmente recorrem&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">A t&#233;cnica de avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas por congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; descrita neste estudo oferece certos benef&#237;cios sobre as t&#233;cnicas de congela&#231;&#227;o padr&#227;o&#46; Um desses benef&#237;cios &#233; que essa t&#233;cnica examina todas as margens perif&#233;ricas e profunda&#44; evitando casos falso&#8208;negativos&#59; &#233; tamb&#233;m uma t&#233;cnica de r&#225;pida execu&#231;&#227;o e de f&#225;cil disponibilidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;7&#44;8&#44;13&#8211;15</span></a> Na <a class="elsevierStyleCrossRef" href="#fig0025">figura 5</a> demonstramos um desenho esquem&#225;tico da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; e da t&#233;cnica de congela&#231;&#227;o padr&#227;o&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0190" class="elsevierStylePara elsevierViewall">Podemos&#44; no entanto&#44; citar algumas limita&#231;&#245;es do uso da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#58; ela n&#227;o permite determinar a dist&#226;ncia entre o tumor e a margem final da pe&#231;a&#46; Mesmo que a margem seja negativa&#44; o tumor pode estar a apenas alguns micr&#244;metros de dist&#226;ncia&#46; Assim&#44; embora uma margem cl&#237;nica livre de 4<span class="elsevierStyleHsp" style=""></span>mm n&#227;o seja necess&#225;ria&#44; ainda &#233; preferido algum grau de margem cl&#237;nica livre ao utilizar a t&#233;cnica &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; para minimizar o risco de uma margem histol&#243;gica livre pequena&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;16&#44;17</span></a> De acordo com a literatura&#44; uma grande parte das recorr&#234;ncias tumorais ocorre ap&#243;s o quinto ano de tratamento&#46; Esse achado enfatiza a import&#226;ncia de um seguimento a longo prazo&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Esse fato demonstra um percal&#231;o em nosso estudo&#44; pois obtivemos um tempo de seguimento mediano de tr&#234;s anos&#46; No entanto&#44; nossos dados s&#227;o compar&#225;veis aos de outros estudos na literatura sobre uso de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">As les&#245;es em que houve discord&#226;ncia entre o resultado da congela&#231;&#227;o intraoperat&#243;ria e o resultado do processamento histopatol&#243;gico com confec&#231;&#227;o de blocos de parafina foram submetidas a tratamento complementar &#40;nova excis&#227;o cir&#250;rgica&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclus&#227;o</span><p id="par0200" class="elsevierStylePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; r&#225;pida&#44; segura e confi&#225;vel para garantir margens cir&#250;rgicas livres de tumor para CBC e CEC&#46; Nossa taxa de recorr&#234;ncia tumoral &#233; aceit&#225;vel&#44; de acordo com a literatura&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Suporte financeiro</span><p id="par0205" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Contribui&#231;&#227;o dos autores</span><p id="par0210" class="elsevierStylePara elsevierViewall">Ana Carolina Vasconcellos Guedes Otsuka&#58; Levantamento dos dados&#44; ou an&#225;lise e interpreta&#231;&#227;o dos dados&#59; Reda&#231;&#227;o do artigo ou revis&#227;o cr&#237;tica do conte&#250;do intelectual importante&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Eduardo Bertolli&#58; Concep&#231;&#227;o e o desenho do estudo&#44; an&#225;lise estat&#237;stica&#59; Reda&#231;&#227;o do artigo ou revis&#227;o cr&#237;tica do conte&#250;do intelectual importante&#59; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Mariana Petaccia de Macedo&#58; Concep&#231;&#227;o e o desenho do estudo&#59; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Clovis Antonio Lopes Pinto&#58; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; Aprova&#231;&#227;o final da vers&#227;o final do manuscrito&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Jo&#227;o Pedreira Duprat Neto&#58; Reda&#231;&#227;o do artigo ou revis&#227;o cr&#237;tica do conte&#250;do intelectual importante&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; aprova&#231;&#227;o final da vers&#227;o final do manuscrito&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflito de interesses</span><p id="par0235" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Os carcinomas cut&#226;neos dos tipos basocelular e espinocelular &#40;CBC e CEC&#41; s&#227;o os tipos mais comuns de c&#226;ncer no mundo&#46; A avalia&#231;&#227;o intraoperat&#243;ria de margens cir&#250;rgicas por congela&#231;&#227;o vem sendo largamente utilizada para assegurar margens livres de doen&#231;a&#46; A t&#233;cnica de congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; avalia todas as margens perif&#233;ricas e profunda&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Relatar os resultados da t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; em rela&#231;&#227;o &#224; recorr&#234;ncia tumoral e &#224; concord&#226;ncia com o exame histopatol&#243;gico em parafina&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise retrospectiva dos pacientes submetidos &#224; ex&#233;rese cir&#250;rgica de CBC e CEC pelo N&#250;cleo de C&#226;ncer de Pele do A&#46;C&#46;Camargo Cancer Center&#44; Brasil&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nosso estudo incluiu 542 carcinomas de pele&#44; que foram excisados de 397 pacientes &#8211; 201 do sexo masculino &#40;50&#44;6&#37;&#41;&#44; 196 do sexo feminino &#40;49&#44;4&#37;&#41;&#44; com idade m&#233;dia de 64 anos&#46; Os tumores foram localizados em sua maioria na regi&#227;o da cabe&#231;a e pesco&#231;o &#40;87&#44;8&#37;&#41;&#46; O CBC correspondeu a 79&#44;7&#37; dos casos&#46; O seguimento m&#233;dio foi de 38 meses&#46; A recidiva tumoral ocorreu em 0&#44;86&#37; para os tumores prim&#225;rios e 3&#44;7&#37; para os tumores recorrentes&#46; O resultado da congela&#231;&#227;o intraoperat&#243;ria &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; foi concordante com o resultado final do exame anatomopatol&#243;gico &#40;exame em parafina&#41; em 98&#37; das les&#245;es&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">N&#227;o ter o tempo de seguimento m&#237;nimo de cinco anos em todos os pacientes&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A t&#233;cnica de congela&#231;&#227;o &#8220;<span class="elsevierStyleItalic">en face</span>&#8221; &#233; uma t&#233;cnica com baixa recidiva tumoral&#44; confi&#225;vel e segura para garantir margens cir&#250;rgicas negativas de tumor&#46;</p></span>"
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;2&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">199&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">P&#225;lpebra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regi&#227;o cervical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tronco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dorso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Flanco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Membros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subtipos histol&#243;gicos de carcinoma cut&#226;neo basocelular</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Superficial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Esclerodermiforme&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Micronodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Misto<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">159&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outros<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de anestesia</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Local exclusiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Local e seda&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Geral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">329&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bloqueio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apresenta&#231;&#227;o inicial da les&#227;o</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Virgem de tratamento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">463&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tumor recidivado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Invas&#227;o perineural</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ausente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">533&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resultado primeira congela&#231;&#227;o</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Margens livres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">392&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Margens comprometidas<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">511&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamento complementar &#40;ap&#243;s a cirurgia&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Radioterapia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cirurgia complementar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamento t&#243;pico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Mais de um subtipo histol&#243;gico&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Outros subtipos de CBC&#58; adenoide e basoescamoso&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Em 116 les&#245;es foi necess&#225;ria uma amplia&#231;&#227;o de margem cir&#250;rgica no intraoperat&#243;rio para obter margens livres de tumor&#46; Em 20 les&#245;es&#44; foram necess&#225;rias duas amplia&#231;&#245;es&#46; Em 11 les&#245;es&#44; foram necess&#225;rias tr&#234;s amplia&#231;&#245;es&#46; Em duas les&#245;es&#44; foram necess&#225;rias quatro amplia&#231;&#245;es&#59; e em uma les&#227;o&#44; foram necess&#225;rios seis amplia&#231;&#245;es de margens cir&#250;rgicas para obter margens livres&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas qualitativas dos pacientes submetidos &#224; ex&#233;rese de carcinomas cut&#226;neos basocelular &#40;CBC&#41; e espinocelular &#40;CEC&#41;&#44; no ano de 2013&#44; de janeiro a dezembro no A&#46;C&#46;Camargo Cancer Center</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">RR&#44; risco relativo&#59; 95&#37; IC&#44; intervalo de confian&#231;a&#59; CBC&#44; carcinoma basocelular&#59; CEC&#44; carcinoma espinocelular&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Vari&#225;vel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o de COX simples</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o de COX m&#250;ltipla</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Invas&#227;o perineural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;507&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;023&#8208;70&#46;758&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;504&#8208;113&#46;216&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de amplia&#231;&#245;es at&#233; obter margens livres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;841&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;170&#8208;2&#46;895&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;872&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;205&#8208;2&#46;907&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Regress&#227;o de Cox simples e m&#250;ltipla com vari&#225;veis associadas &#224; sobrevida livre de recorr&#234;ncia em pacientes submetidos a ex&#233;rese de CBC e CEC&#44; no ano de 2013&#44; de janeiro a dezembro no A&#46;C&#46;Camargo Cancer Center</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">OR&#44; odds ratio&#59; 95&#37; IC&#44; intervalo de confian&#231;a&#59; CBC&#44; carcinoma basocelular&#59; CEC&#44; carcinoma espinocelular&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Vari&#225;vel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o log&#237;stica simples</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regress&#227;o log&#237;stica m&#250;ltipla</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de les&#245;es operadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;227&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;089&#8208;1&#46;383&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;243&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;101&#8208;1&#46;403&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de amplia&#231;&#245;es at&#233; margens livres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;945&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;231&#8208;3&#46;073&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;035&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;237&#8208;3&#46;347&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Regress&#227;o log&#237;stica simples e m&#250;ltipla com vari&#225;veis associadas ao resultado final do anatomopatol&#243;gico &#40;concordante e discordante&#41; em pacientes submetidos a ex&#233;rese de CBC e CEC&#44; no ano de 2013&#44; de janeiro a dezembro no A&#46;C&#46;Camargo Cancer Center</p>"
        ]
      ]
      8 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">CBC&#44; carcinoma basocelular&#59; CEC&#44; carcinoma espinocelular&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Per&#237;odo estudado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero de les&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Localiza&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Seguimento &#40;meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Taxa de recorr&#234;ncia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gayre et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1985 a 2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1638&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1992 a 2001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">534&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;2&#37;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gill et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1997 a 2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resti et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1998 a 2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC palpebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kvannli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1999 a 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">262&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC e CEC periorbitais&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Menesi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2002 a 2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC na face&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tullett et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2003 a 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC periocular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nizamoglu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2010 a 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinomas de alto risco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presente estudo<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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Article information
ISSN: 26662752
Original language: Portuguese
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2024 January 169 67 236
2023 December 151 63 214
2023 November 180 95 275
2023 October 194 78 272
2023 September 208 90 298
2023 August 219 40 259
2023 July 202 57 259
2023 June 183 56 239
2023 May 165 33 198
2023 April 131 42 173
2023 March 137 45 182
2023 February 70 40 110
2023 January 108 52 160
2022 December 128 47 175
2022 November 146 81 227
2022 October 130 105 235
2022 September 113 102 215
2022 August 62 54 116
2022 July 19 20 39
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