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conhecido por estar associado a alelos HLA e fatores ambientais&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">2&#8211;4</span></a> &#201; interessante notar que sua apresenta&#231;&#227;o cl&#237;nica tem sido associada a milia nas cicatrizes de les&#245;es bolhosas ou na pele n&#227;o lesionada em certos pacientes com PB&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">5</span></a> A presen&#231;a de milia est&#225; associada principalmente &#224; epiderm&#243;lise bolhosa adquirida &#40;EBA&#41; e porfiria cut&#226;nea tardia&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">6&#44;7</span></a> Prost et al&#46; &#40;1987&#41; descreveram a presen&#231;a de milia em casos de EBA e penfigoide cicatricial&#44; mas les&#245;es de milia estavam ausentes nos pacientes analisados com PB&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">8</span></a> Relatos sobre a associa&#231;&#227;o PB&#8208;milia v&#234;m aumentando nas &#250;ltimas d&#233;cadas em popula&#231;&#245;es diversas&#44; mas sua preval&#234;ncia e dados cl&#237;nico&#8208;laboratoriais ainda n&#227;o foram relatados na popula&#231;&#227;o brasileira com PB&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">9&#8211;15</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Dos 102 casos de PB compilados&#44; relatamos oito pacientes que apresentaram associa&#231;&#227;o com milia&#46; Avaliamos os achados cl&#237;nicos&#44; laboratoriais e de <span class="elsevierStyleItalic">immunoblotting</span> e determinamos os alelos HLA&#8208;DQ nesses oito pacientes com PB&#8208;milia&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Este estudo descritivo foi aprovado pelo Comit&#234; de &#201;tica local &#40;n&#176; 12248&#47;2010&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Foram revisados os prontu&#225;rios de 102 pacientes diagnosticados com PB em um per&#237;odo de 35 anos&#46; Todos eles moravam na regi&#227;o sudeste do Brasil&#46; O diagn&#243;stico de PB foi baseado em achados cl&#237;nicos&#44; confirmados pela presen&#231;a de bolhas subepid&#233;rmicas ao exame histopatol&#243;gico e por fluoresc&#234;ncia linear de IgG na zona da membrana basal &#40;ZMB&#41; por imunofluoresc&#234;ncia direta e indireta &#40;IFD e IFI&#44; respectivamente&#41;&#46; A IFI com anti&#8208;IgA e anti&#8208;IgG foi realizada pelo m&#233;todo <span class="elsevierStyleItalic">salt&#8208;split skin</span> &#40;SSS&#41;&#46; Os autoanticorpos IgG anti&#8208;BP180 e anti&#8208;BP230 foram determinados por ensaios ELISA &#40;valor de corte<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9 U&#47;mL&#59; MBL&#44; Jap&#227;o&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Os dados cl&#237;nicos foram avaliados para os oito pacientes com PB&#8208;milia inclu&#237;dos neste estudo&#44; e ensaios laboratoriais foram realizadas em amostras de DNA e soro armazenados&#46; Para a determina&#231;&#227;o de IgE total&#44; 50<span class="elsevierStyleHsp" style=""></span>&#956;L de soro foram preparados de acordo com as recomenda&#231;&#245;es do fabricante &#40;ImmunoCAPTM Total IgE&#44; Thermo&#8208;Fisher&#44; EUA&#41;&#46; A titula&#231;&#227;o foi realizada em Phadia100 &#40;Thermo&#8208;Fisher&#44; EUA&#41;&#46; Foram realizados os testes de <span class="elsevierStyleItalic">immunoblotting</span> &#40;IB&#41; com ant&#237;genos ZMB&#58; e com os dom&#237;nios C&#8208;terminais BP180&#8208;NC16a e BP180&#44; mol&#233;culas de BP230&#44; LAD&#8208;1&#44; col&#225;geno tipo VII e laminina&#8208;332&#46; Os alelos HLA&#8208;DQ foram determinados por PCR combinada com sondas oligonucleot&#237;dicas sequ&#234;ncia&#8208;espec&#237;ficas &#40;PCR&#8208;SSOP&#41;&#46; O kit LAB Type &#40;One Lambda Inc&#46;&#44; Kittredge&#44; CA&#44; EUA&#41; foi utilizado de acordo com as instru&#231;&#245;es do fabricante e a tecnologia Luminex&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="par0035" class="elsevierStylePara elsevierViewall">Dos 102 casos de PB compilados&#44; oito apresentaram les&#245;es de milia &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1 e 2</a>&#41;&#44; correspondendo &#224; preval&#234;ncia de PB&#8208;milia de 7&#44;8&#37;&#46; A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> resume os dados demogr&#225;ficos e cl&#237;nicos desses oito pacientes&#46; Cinco eram do sexo masculino&#59; a mediana da idade era de 75&#44;5 anos&#59; e a mediana da dura&#231;&#227;o da doen&#231;a era de cinco meses&#46; A descri&#231;&#227;o cl&#237;nica mostrou les&#245;es ativas de PB nos oito pacientes&#46; Apenas um paciente apresentou acometimento mucoso&#46; Nenhum deles havia mudado sua medica&#231;&#227;o habitual antes do in&#237;cio do PB&#46; Digno de nota&#44; quatro pacientes apresentavam doen&#231;as neurol&#243;gicas &#40;DN&#41;&#46; Sete pacientes responderam bem ao tratamento usual&#44; e um faleceu em decorr&#234;ncia de tromboembolismo pulmonar ap&#243;s cirurgia de h&#233;rnia de disco&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> detalha os achados laboratoriais&#46; Seis dos sete pacientes apresentavam bolha subepid&#233;rmica&#44; e infiltrado inflamat&#243;rio eosinof&#237;lico na derme superior predominou em quatro pacientes ao exame histopatol&#243;gico&#46; Em cinco desses pacientes&#44; a IFD confirmou IgG ou C3&#44; ou ambos&#44; mas nenhuma fluoresc&#234;ncia linear de IgA na ZMB &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>A&#41;&#46; Em oito pacientes&#44; SSS&#8208;IFI demonstrou IgG ou C3&#44; ou ambos&#44; mas nenhuma fluoresc&#234;ncia linear de IgA no lado epid&#233;rmico da clivagem &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>B&#41;&#46; De interesse&#44; o aumento dos n&#237;veis s&#233;ricos de IgE total variando de 252 a &#62;<span class="elsevierStyleHsp" style=""></span>5&#46;000 kU&#47;mL foi documentado em sete dos oito pacientes&#46; Entre os oito pacientes&#44; o teste ELISA mostrou n&#237;veis aumentados de anticorpos anti&#8208;BP180&#44; anti&#8208;BP230 e em ambos anti&#8208;BP180 e anti&#8208;BP230 em dois&#44; um e tr&#234;s pacientes&#44; respectivamente&#59; dois pacientes testaram negativo para os anticorpos anti&#8208;BP180 e anti&#8208;BP230&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Entre os oito pacientes&#44; os testes de IB destacaram a reatividade de IgG contra BP230 em um paciente &#40;dados n&#227;o mostrados&#41;&#44; contra o dom&#237;nio BP180&#8208;NC16a em cinco pacientes &#40;<a class="elsevierStyleCrossRef" href="#fig0020">fig&#46; 4</a>A&#41; e contra o dom&#237;nio C&#8208;terminal de BP180 ou LAD&#8208;1&#44; ou ambos&#44; em quatro pacientes &#40;<a class="elsevierStyleCrossRef" href="#fig0020">figs&#46; 4</a>B e C&#41;&#46; Nenhum paciente apresentou reatividade contra col&#225;geno tipo VII ou laminina&#8208;332&#46; Os alelos HLA&#8208;DQ foram definidos em cinco dos oito pacientes &#40;ver <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#44; &#250;ltima coluna&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discuss&#227;o</span><p id="par0050" class="elsevierStylePara elsevierViewall">Que seja de nosso conhecimento&#44; a associa&#231;&#227;o PB&#8208;milia ainda &#233; considerada um achado cl&#237;nico incomum&#46;<span class="elsevierStyleSup">5&#44;9&#8211;15</span> N&#227;o h&#225; relato da associa&#231;&#227;o PB&#8208;milia na popula&#231;&#227;o brasileira&#46; Aqui&#44; &#233; apresentada a preval&#234;ncia de 7&#44;8&#37; de associa&#231;&#227;o PB&#8208;milia em 102 pacientes com PB&#44; indicando que o diagn&#243;stico diferencial cuidadoso com EBA &#233; obrigat&#243;rio&#44; visto que a forma&#231;&#227;o de milia &#233; frequentemente relatada em EBA&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Em virtude do aumento do dos relatos da associa&#231;&#227;o PB&#8208;milia&#44; &#233; interessante destacar algumas caracter&#237;sticas cl&#237;nicas e laboratoriais apresentadas pelos oito pacientes PB&#8208;milia&#58; &#40;i&#41; Associa&#231;&#227;o com DN foi descrita em quatro pacientes &#8208; tr&#234;s com acidente vascular cerebral &#40;pacientes 3&#44; 5 e 6&#41; e um com doen&#231;a de Parkinson e dem&#234;ncia &#40;paciente 8&#41;&#46; DN em associa&#231;&#227;o com PB estabelece uma rela&#231;&#227;o interessante para a patog&#234;nese do PB&#44;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">4&#44;16</span></a> mas nenhuma associa&#231;&#227;o DN&#8208;PB&#8208;milia foi encontrada na literatura&#46; &#40;ii&#41; N&#237;veis de IgE total aumentados foram demonstrados em sete pacientes&#46; O aumento da IgE total foi relacionado &#224; gravidade do PB&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">17&#8211;20</span></a> e foi relatado em um caso de associa&#231;&#227;o de PB&#8208;milia&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">13</span></a> O fato do aumento da IgE total ter sido identificado em 87&#44;5&#37; dos pacientes com PB&#8208;milia aqui inclu&#237;dos merece confirma&#231;&#227;o futura&#46; &#40;iii&#41; Curiosamente&#44; quatro pacientes apresentaram anticorpos contra o dom&#237;nio C&#8208;terminal de BP180 e LAD&#8208;1 em IB&#46; A intera&#231;&#227;o de prote&#237;nas hemidesmoss&#244;micas e componentes da matriz extracelular sob os hemidesmossomos tamb&#233;m pode resultar na forma&#231;&#227;o de milia&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">5</span></a> mas essas caracter&#237;sticas n&#227;o s&#227;o exclusivas da associa&#231;&#227;o PB&#8208;milia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Por fim&#44; os genes HLA s&#227;o provavelmente o fator de predisposi&#231;&#227;o gen&#233;tica mais significativo na patog&#234;nese da PB&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">2</span></a> Na maior s&#233;rie de casos de associa&#231;&#227;o PB&#8208;milia at&#233; o momento&#44; les&#245;es de milia estavam presentes em 23 &#40;31&#44;1&#37;&#41; dos 74 pacientes brit&#226;nicos com PB&#44; e o grupo al&#233;lico <span class="elsevierStyleItalic">HLA&#8208;DQ6</span> foi associado &#224; condi&#231;&#227;o PB&#8208;milia&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">21</span></a> Aqui&#44; tr&#234;s dos cinco casos apresentavam o grupo al&#233;lico <span class="elsevierStyleItalic">HLA&#8208;DQB1&#42;06</span>&#46; Al&#233;m disso&#44; tr&#234;s exibiam os alelos <span class="elsevierStyleItalic">HLA</span>&#8208;<span class="elsevierStyleItalic">DQA1</span>&#42;01&#58;03&#47;05&#58;05&#44; o alelo <span class="elsevierStyleItalic">HLA&#8208;DQB1&#42;03&#58;01</span>&#44; ou todos eles&#44; que representam alelos de suscetibilidade ao PB na popula&#231;&#227;o brasileira&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclus&#227;o</span><p id="par0065" class="elsevierStylePara elsevierViewall">Em conclus&#227;o&#44; les&#245;es de milia parecem ser uma descri&#231;&#227;o cl&#237;nica atual associada ao PB&#44; configurando um diagn&#243;stico diferencial especial com outras doen&#231;as bolhosas&#46; A forma&#231;&#227;o de milia em PB merece uma explica&#231;&#227;o baseada na patog&#234;nese do motivo pelo qual certos pacientes com PB as desenvolvem&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Suporte financeiro</span><p id="par0070" class="elsevierStylePara elsevierViewall">Este estudo foi parcialmente financiado pela FAPESP &#40;Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo&#41;&#44; processo n&#250;mero 2010&#47;51729&#8208;2&#44; e pela FAEPA &#40;Funda&#231;&#227;o de Apoio ao Ensino&#44; Pesquisa e Assist&#234;ncia&#41;&#46; SV e TAJ receberam bolsa de doutorado da CAPES &#40;Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de N&#237;vel Superior&#41; e da FAPESP&#44; respectivamente&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Contribui&#231;&#227;o dos autores</span><p id="par0075" class="elsevierStylePara elsevierViewall">Sebasti&#225;n Vernal&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; reda&#231;&#227;o do manuscrito&#44; participa&#231;&#227;o efetiva&#44; revis&#227;o da literatura&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Ederson Valei de Oliveira&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o efetiva&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Roberto Bueno Filho&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o efetiva&#44; participa&#231;&#227;o em conduta terap&#234;utica dos casos estudados&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Tamiris A&#46; Julio&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o efetiva&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Eduardo A&#46; Donadi&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o efetiva&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Aline Turatti&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o efetiva&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Norito Ishii&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o efetiva&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Takashi Hashimoto&#58; Contribuiu com a obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; participa&#231;&#227;o efetiva&#44; reda&#231;&#227;o do manuscrito&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Ana Maria Roselino&#58; Contribuiu com a concep&#231;&#227;o e planejamento do estudo&#44; obten&#231;&#227;o e interpreta&#231;&#227;o dos dados&#44; reda&#231;&#227;o do manuscrito&#44; participa&#231;&#227;o efetiva&#44; revis&#227;o da literatura&#44; participa&#231;&#227;o em conduta terap&#234;utica dos casos estudados&#44; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflito de interesses</span><p id="par0120" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A associa&#231;&#227;o entre penfigoide bolhoso &#40;PB&#41; e les&#245;es de milia tem sido cada vez mais relatada&#44; mas sua preval&#234;ncia ainda n&#227;o havia sido relatada em uma popula&#231;&#227;o brasileira com PB&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Descrever a ocorr&#234;ncia e os achados cl&#237;nico&#8208;laboratoriais da associa&#231;&#227;o PB&#8208;milia em uma amostra da regi&#227;o sudeste brasileira&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Realizou-se estudo descritivo baseado nos prontu&#225;rios de 102 pacientes com PB&#46; Dados cl&#237;nicos e laboratoriais de pacientes com PB&#8208;milia foram obtidos&#46; IgE s&#233;rica total&#44; ensaios de <span class="elsevierStyleItalic">immunoblotting</span> com base em ant&#237;genos da zona da membrana basal e tipagem de alelos HLA&#8208;DQ foram realizados&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Les&#245;es de milia foram evidentes em oito &#40;7&#44;8&#37;&#41; pacientes com PB&#44; cinco do sexo masculino&#44; com idade entre 46 e 88 anos&#46; N&#237;veis elevados de IgE total foram determinados em sete &#40;87&#44;5&#37;&#41; de oito pacientes&#46; Em cinco dos oito pacientes&#44; o <span class="elsevierStyleItalic">immunoblotting</span> mostrou reatividade de IgG contra o dom&#237;nio BP180&#8208;NC16a&#44; mas n&#227;o contra col&#225;geno VII ou laminina&#8208;332&#59; tamb&#233;m revelou reatividade contra o dom&#237;nio C&#8208;terminal de BP180 ou LAD&#8208;1&#44; ou ambos em quatro deles&#46; Os alelos <span class="elsevierStyleItalic">HLA&#8208;DQB1</span>&#42;03&#58;01 e <span class="elsevierStyleItalic">HLA&#8208;DQA1</span>&#42;05&#58;05 foram identificados em tr&#234;s desses cinco pacientes com PB&#8208;milia&#46; Al&#233;m disso&#44; tr&#234;s dos cinco casos apresentaram o grupo al&#233;lico <span class="elsevierStyleItalic">HLA-DQB1&#42;</span>06&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O HLA foi determinado em cinco pacientes&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#245;es</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A forma&#231;&#227;o de milia em pacientes com PB parece ser menos incomum do que anteriormente admitido&#46; Os dados laboratoriais revelaram aumento de IgE&#59; autoanticorpos contra o dom&#237;nio C&#8208;terminal de BP180 ou LAD&#8208;1&#44; ou ambos&#59; e o grupo al&#233;lico <span class="elsevierStyleItalic">HLA-DQB1&#42;</span>06&#44; descrito na associa&#231;&#227;o PB&#8208;milia&#46; A determina&#231;&#227;o cuidadosa de anticorpos contra mol&#233;culas da zona da membrana basal e a caracteriza&#231;&#227;o do HLA em diferentes popula&#231;&#245;es podem fornecer mais informa&#231;&#245;es sobre essa associa&#231;&#227;o&#46;</p></span>"
        "secciones" => array:6 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Fundamentos"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objetivos"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "M&#233;todos"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Limita&#231;&#245;es do estudo"
          ]
          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Conclus&#245;es"
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        ]
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    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Como citar este artigo&#58; Vernal S&#44; Oliveira EV&#44; Bueno Filho R&#44; Julio TA&#44; Donadi EA&#44; Turatti A&#44; et al&#46; Bullous pemphigoid and milia&#58; prevalence and clinical laboratory findings in a Brazilian sample&#46; An Bras Dermatol&#46; 2022&#59;97&#58;435&#8211;42&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Trabalho realizado no Hospital Universit&#225;rio&#44; Faculdade de Medicina de Ribeir&#227;o Preto&#44; Universidade de S&#227;o Paulo&#44;&#160;Ribeir&#227;o Preto&#44;&#160;SP&#44; Brasil e na Kurume University Institute of Cutaneous Cell Biology&#44; &#223;ukuoka&#44; Jap&#227;o&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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            "Alto" => 866
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 2 nas tabelas 1 e 2&#46; &#40;A&#41;&#44; Les&#245;es crostosas sobre placas eritematosas no t&#243;rax anterior e abd&#244;men&#46; &#40;B&#41;&#44; Les&#245;es de milia &#40;<span class="elsevierStyleItalic">setas brancas</span>&#41; sobre les&#245;es cicatriciais podem ser vistas nessa imagem com amplia&#231;&#227;o&#46;</p>"
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      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 715
            "Ancho" => 2005
            "Tamanyo" => 125387
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 4 nas tabelas 1 e 2&#46; &#40;A&#41;&#44; Bolha hemorr&#225;gica e tensa sobre placas eritematosas no p&#233;&#46; &#40;B&#41;&#44; Les&#245;es de milia &#40;<span class="elsevierStyleItalic">seta branca</span>&#41; sobre les&#245;es cicatriciais podem ser vistas&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 689
            "Ancho" => 2000
            "Tamanyo" => 148977
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41;&#44; Imunofluoresc&#234;ncia direta em bi&#243;psia de pele mostrando fluoresc&#234;ncia linear de IgG na zona da membrana basal &#40;<span class="elsevierStyleItalic">seta branca</span>&#59; paciente 2&#41;&#46; Imunofluoresc&#234;ncia&#44; 400<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#46; &#40;B&#41;&#44; Imunofluoresc&#234;ncia indireta utilizando 1M&#8208;NaCl&#8208;salt&#8208;split skin mostra fluoresc&#234;ncia de IgG no lado epid&#233;rmico de clivagem &#40;paciente&#160;5&#41;&#46; Imunofluoresc&#234;ncia&#44; 400<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#46;</p>"
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      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figura 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Immunoblotting</span> utilizando BP180&#8208;NC16a &#40;A&#41; C&#8208;terminal BP180 &#40;B&#41; e c&#233;lulas HaCaT &#40;C&#41; com amostras de soro&#46; Para resultados positivos&#44; procure a prote&#237;na de refer&#234;ncia &#40;PR&#41; de&#58; soro do paciente PB &#40;penfigoide bolhoso&#41; &#40;A&#41;&#44; MMP&#44; soro do paciente com penfigoide das membranas mucosas &#40;B&#41; e LAD&#58; soro do paciente com dermatose IgA linear &#40;C&#41;&#46;</p>"
        ]
      ]
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        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero do paciente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sexo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Idade &#40;anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dura&#231;&#227;o da doen&#231;a &#40;meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Distribui&#231;&#227;o das les&#245;es&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hist&#243;rico m&#233;dico e comorbidades&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Medicamentos em uso no in&#237;cio das les&#245;es de PB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tronco&#44; membros&#44; m&#227;os e p&#233;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Erisipela recorrente&#44; hipertens&#227;o&#44; dislipidemia e c&#226;ncer de bexiga ressecado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enalapril&#44; amlodipina&#44; sinvastatina&#44; carvedilol e omeprazol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tronco&#44; abdome e membros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Doen&#231;a da tireoide&#44; hipertens&#227;o&#44; diabetes <span class="elsevierStyleItalic">mellitus</span> tipo 2 e hist&#243;ria de histoplasmose pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Metformina&#44; losartana&#44; aspirina&#44; ramipril&#44; omeprazol e atorvastatina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tronco e membros inferiores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertens&#227;o&#44; diabetes <span class="elsevierStyleItalic">mellitus</span> tipo 2 e acidente vascular encef&#225;lico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aspirina&#44; carvedilol&#44; furosemida&#44; dinitrato de isossorbida&#44; omeprazol&#44; NPH e insulina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pesco&#231;o&#44; tronco e membros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertens&#227;o&#44; hipotireoidismo&#44; hiperparatireoidismo e asma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Losartana&#44; amlodipina&#44; levotiroxina&#44; ranitidina&#44; duloxetina&#44; pregabalina&#44; primidona&#44; carbonato de c&#225;lcio&#44; pidolato de magn&#233;sio&#44; cloreto de pot&#225;ssio&#44; &#225;cido f&#243;lico e vitamina E&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tronco e m&#227;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertens&#227;o&#44; diabetes <span class="elsevierStyleItalic">mellitus</span> tipo 2&#44; dislipidemia e acidente vascular encef&#225;lico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hidroclorotiazida&#44; atenolol&#44; aspirina&#44; fenito&#237;na&#44; metformina&#44; sinvastatina&#44; diosmina&#44; indapamida e cilostazol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Couro cabeludo&#44; face&#44; tronco&#44; abd&#244;men e membros superiores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertens&#227;o&#44; dislipidemia&#44; tabagismo&#44; alcoolismo&#44; infec&#231;&#227;o urin&#225;ria de repeti&#231;&#227;o&#44; acidente vascular encef&#225;lico e epis&#243;dio de psicose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hidroclorotiazida&#44; sinvastatina&#44; clopidogrel&#44; nortriptilina e amiodarona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regi&#227;o axilar&#44; coxas e p&#233;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cefaleia cr&#244;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Desogestrel&#44; etinilestradiol e metamizol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mucosa oral&#44; t&#243;rax&#44; m&#227;os e p&#233;s e regi&#227;o inguinal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Doen&#231;a de Parkinson e dem&#234;ncia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prolopa&#44; domperidona&#44; omeprazol&#44; doxiciclina e nicotinamida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Dados demogr&#225;ficos e cl&#237;nicos de pacientes com associa&#231;&#227;o PB&#8208;milia</p>"
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        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
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          0 => array:3 [
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        "tabla" => array:3 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">PB&#44; penfigoide bolhoso&#59; IFD&#44; imunofluoresc&#234;ncia direta com deposi&#231;&#227;o de fluoresc&#234;ncia linear ao longo da zona da membrana basal&#59; SSS&#8208;IFI&#44; m&#233;todo <span class="elsevierStyleItalic">salt&#8208;split skin</span> na imunofluoresc&#234;ncia indireta com fluoresc&#234;ncia linear na clivagem epid&#233;rmica&#59; fluoresc&#234;ncia IgA negativa&#46; N&#46;D&#46;&#44; n&#227;o dispon&#237;vel&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero do paciente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;sticas histopatol&#243;gicas na bi&#243;psia de pele&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IFD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SSS&#8208; IFI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IgE s&#233;rico &#40;kU&#47;mL&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti&#8208;BP180 &#40;U&#47;mL&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti&#8208;BP230 &#40;U&#47;mL&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Achados de <span class="elsevierStyleItalic">Immunoblotting</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Alelos<span class="elsevierStyleItalic">HLA&#8208;DQ</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bolha subepid&#233;rmica com eosin&#243;filos dentro da bolha e na derme superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG e C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG e C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 5000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dom&#237;nio BP180&#8208;NC16a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;D&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Descolamento epid&#233;rmico&#59; infiltrado inflamat&#243;rio com linf&#243;citos&#44; neutr&#243;filos e eosin&#243;filos na derme superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C3 e fibrinog&#234;nio&#59; IgG negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG e C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 5000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dom&#237;nio C&#8208;terminal BP180 e LAD&#8208;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;D&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Epiderme exibindo leve espongiose&#46; Discreto infiltrado inflamat&#243;rio linfocit&#225;rio intersticial na derme superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">782&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhum&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Foco de descolamento epid&#233;rmico&#46; Infiltrado inflamat&#243;rio perivascular e intersticial leve com linf&#243;citos na derme superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG e C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG e C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 5000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">159&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">72&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dom&#237;nio BP180&#8208;NC16a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">DQA1&#42;</span> 01&#58;02&#47;02&#58;01&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">DQB1&#42;</span> 02&#58;02&#47;06&#58;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;D&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG e C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">252&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BP180&#8208;NC16a&#44; dom&#237;nio C&#8208;terminal BP180&#44; e LAD&#8208;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">DQA1&#42;</span> 01&#58;01&#47;05&#58;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">DQB1&#42;</span> 03&#58;01&#47;05&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ves&#237;cula subepid&#233;rmica com fibrina&#44; neutr&#243;filos e linf&#243;citos&#46; Moderado infiltrado linfocit&#225;rio perianexial&#44; perivascular e intersticial na derme superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1286&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">68&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BP230&#59; dom&#237;nio C&#8208;terminal BP180&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">DQA1&#42;</span> 01&#58;02&#47;02&#58;01&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">DQB1&#42;</span> 02&#58;02&#47;06&#58;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ves&#237;cula subepid&#233;rmica&#59; infiltrado inflamat&#243;rio com numerosos eosin&#243;filos e linf&#243;citos na derme superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;D&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BP180&#8208;NC16a&#44; dom&#237;nio C&#8208;terminal BP180&#44; e LAD&#8208;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">DQA1&#42;</span> 05&#58;05&#47;05&#58;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">DQB1&#42;</span> 03&#58;01&#47;03&#58;01&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Ves&#237;cula subepid&#233;rmica com alguns eosin&#243;filos em seu interior&#59; ceratin&#243;citos necr&#243;ticos no assoalho da clivagem&#46; Infiltrado inflamat&#243;rio intersticial e perivascular com predom&#237;nio de linf&#243;citos e eosin&#243;filos na derme superior&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">427&nbsp;\t\t\t\t\t\t\n
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          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Dados laboratoriais de pacientes com associa&#231;&#227;o PB&#8208;milia</p>"
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