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composta por&#160;10&#160;subst&#226;ncias &#40;todas baterias elaboradas pela Asacpharma&#174;&#41;&#46; Todos os pacientes com rea&#231;&#245;es positivas ou duvidosas &#224; leitura de&#160;96&#160;horas &#40;segunda leitura ou leitura final&#41; foram inclu&#237;dos para avalia&#231;&#227;o dermatosc&#243;pica&#46; Os pacientes com testes negativos &#224; leitura de&#160;96&#160;horas foram exclu&#237;dos&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A avalia&#231;&#227;o &#40;leitura&#41; dos testes &#224;s&#160;96&#160;horas foi interpretada a olho nu &#40;por dermatologista <span class="elsevierStyleItalic">expert</span>&#160;&#8211;&#160;R&#46;R&#46;B&#46; e dermatologista pesquisadora&#160;&#8211;&#160;K&#46;O&#46;&#41;&#44; de acordo com os crit&#233;rios do International Contact Dermatitis Research Group &#40;ICDRG&#41;&#44; que seguem&#58; rea&#231;&#227;o duvidosa &#8211; algum eritema&#160;&#40;&#63;&#41;&#59; rea&#231;&#227;o leve &#8211; eritema definido&#44; leve infiltra&#231;&#227;o e p&#225;pulas eventuais&#160;&#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; rea&#231;&#227;o forte &#8211; eritema definido&#44; infiltra&#231;&#227;o&#44; p&#225;pulas e ves&#237;culas eventuais&#160;&#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; rea&#231;&#227;o muito forte &#8211; eritema intenso&#44; infiltra&#231;&#227;o e ves&#237;culas coalescentes &#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;15</span></a> Rea&#231;&#245;es duvidosas ou positivas em 48 horas e que tornaram&#8208;se negativas &#224; leitura a olho nu &#40;aus&#234;ncia de eritema&#41; em 96 horas&#44; foram classificadas como rea&#231;&#245;es irritativas&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A interpreta&#231;&#227;o dos testes de contato por meio da dermatoscopia foi realizada com aux&#237;lio de dermatosc&#243;pio Dermlite4 &#40;aumento de&#160;10&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#44; e as imagens das rea&#231;&#245;es foram registradas com <span class="elsevierStyleItalic">Handyscope FotoFinder</span>&#174; &#40;aumento de 20&#215;<span class="elsevierStyleHsp" style=""></span>&#41; e FotoFinder&#174; &#40;aumento de 40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#44; com camada espessa de gel de interface e m&#237;nima press&#227;o&#46; As imagens dermatosc&#243;picas foram obtidas pela dermatologista pesquisadora &#40;K&#46;O&#46;&#41; e avaliadas por R&#46;R&#46;B&#46; e K&#46;O&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Os resultados obtidos pela avalia&#231;&#227;o dermatosc&#243;pica envolveram as vari&#225;veis a seguir&#58; &#8208; &#193;rea total de acometimento da pele no local da c&#226;mara&#58; at&#233;&#160;50&#37; ou maior de&#160;50&#37;&#59; &#8208; Eritema homog&#234;neo&#58; eritema difuso na maior parte da &#225;rea da c&#226;mara&#59; &#8208; Eritema perifolicular&#58; eritema essencialmente em torno dos &#243;stios foliculares&#59; &#8208; P&#225;pulas &#8211; &#225;reas mais claras simulando um v&#233;u&#44; mal&#8208;delimitadas&#59; &#8208; Ves&#237;culas&#47;bolhas &#8211; c&#237;rculos esbranqui&#231;ados de diferentes tamanhos que lembram bolhas de sab&#227;o&#59; &#8208; P&#250;stulas&#58; c&#237;rculos amarelados&#59; &#8208; Crostas&#58; material s&#243;lido e aderido proveniente de ressecamento de l&#237;quido&#59; &#8208; Rea&#231;&#227;o p&#243;rica &#40;ou obstru&#231;&#227;o folicular&#41;&#58; padr&#227;o de rea&#231;&#227;o folicular&#44; podendo ser pigmento amarronzado ou forma&#231;&#227;o de crost&#237;culas nos &#243;stios foliculares&#59; &#8208; Acentua&#231;&#227;o folicular&#58; m&#250;ltiplos pequenos pontos branco&#8208;acinzentados do mesmo tamanho&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">As altera&#231;&#245;es vasculares foram classificadas em&#58; &#8208; Vasos puntiformes&#58; pequenos pontos&#59; &#8208; Lineares&#59; &#8208; Polim&#243;rficos&#58; quando n&#227;o seguem um padr&#227;o e se apresentam com mais de uma forma&#59; &#8208; Pet&#233;quias&#58; colora&#231;&#227;o purp&#250;rica que n&#227;o desaparece &#224; vitropress&#227;o&#46; Esses crit&#233;rios foram escolhidos a partir de estudos previamente publicados e adaptados de acordo com a experi&#234;ncia dos autores&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8&#44;16&#44;17</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es al&#233;rgicas t&#234;m como principais caracter&#237;sticas dermatosc&#243;picas o eritema homog&#234;neo e difuso&#44; envolvendo ou n&#227;o a &#225;rea folicular&#44; as p&#225;pulas e as forma&#231;&#245;es l&#237;quidas&#46; H&#225; a possibilidade de um conjunto de modifica&#231;&#245;es acess&#243;rias e secund&#225;rias como crostas&#44; rea&#231;&#227;o p&#243;rica e acentua&#231;&#227;o folicular&#59; por&#233;m esses achados isoladamente&#44; sem a forma&#231;&#227;o de eritema homog&#234;neo &#40;com ou sem p&#225;pulas e forma&#231;&#245;es l&#237;quidas&#41;&#44; n&#227;o se configuram em rea&#231;&#245;es do tipo al&#233;rgicas&#46; As altera&#231;&#245;es vasculares s&#227;o achados acess&#243;rios&#44; tamb&#233;m&#44; a serem mais explorados&#44; como neste estudo&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es irritativas n&#227;o foram consideradas especificamente na an&#225;lise&#44; pois o objetivo era avaliar as rea&#231;&#245;es que permaneceram com eritema nas 96 horas&#44; mas &#233; importante citar que as caracter&#237;sticas dermatosc&#243;picas das rea&#231;&#245;es irritativas s&#227;o descritas como rea&#231;&#227;o p&#243;rica e&#47;ou rea&#231;&#227;o perifolicular&#44; na aus&#234;ncia do eritema homog&#234;neo de base&#46; Igualmente ao que ocorre com nas rea&#231;&#245;es al&#233;rgicas&#44; n&#227;o h&#225; um definido padr&#227;o de altera&#231;&#245;es vasculares espec&#237;ficos para as rea&#231;&#245;es irritativas&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8&#44;17</span></a> Neste estudo&#44; os resultados com rea&#231;&#245;es irritativas foram considerados negativos para DAC&#44; ap&#243;s a dermatoscopia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">As informa&#231;&#245;es coletadas foram digitadas em base de dados no programa Microsoft Excel&#44; processados e analisados com aux&#237;lio do programa SPSS vers&#227;o&#160;25&#46; Os dados foram apresentados por meio de frequ&#234;ncias e percentuais&#44; e a idade por m&#233;dia e desvio&#8208;padr&#227;o&#46; As associa&#231;&#245;es foram verificadas por meio do teste Qui&#8208;Quadrado ou teste Exato de Fisher&#44; quando adequado&#46; O resultado antes foi comparado com o depois&#44; pel teste McNemmar&#46; Foram considerados resultados significativos quando&#160;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="par0065" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos&#160;77&#160;pacientes&#44; em um total de&#160;160&#160;rea&#231;&#245;es&#46; Verifica&#8208;se que a maioria da amostra foi composta por mulheres &#40;77&#44;9&#37;&#41;&#44; com ampla variabilidade et&#225;ria e de fototipos&#44; e hist&#243;ria pessoal de atopia em&#160;15&#44;6&#37; dos pacientes&#44; A maioria foi testada com a bateria padr&#227;o &#40;76&#44;6&#37;&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">As subst&#226;ncias mais prevalentes foram o sulfato de n&#237;quel &#40;23&#44;8&#37;&#41;&#44; o grupo das isotiazolinonas &#8211; &#8220;Kathon CG&#8221; &#40;9&#44;4&#37;&#41; e o grupo de perfumes &#8211; &#8220;Perfume&#8208;mix&#8221; &#40;8&#44;8&#37;&#41;&#46; As caracter&#237;sticas gerais dos pacientes que foram submetidos &#224; leitura dos testes de contato com a dermatoscopia est&#227;o descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Os principais achados dermatosc&#243;picos dos pacientes com DCA foram &#225;rea da rea&#231;&#227;o maior do que a metade do local da c&#226;mara &#40;90&#37;&#41;&#44; eritema homog&#234;neo &#40;86&#44;9&#37;&#41;&#44; ves&#237;culas &#40;30&#37;&#41;&#44; crostas &#40;21&#44;3&#37;&#41;&#44; eritema perifolicular &#40;35&#37;&#41;&#44; p&#250;stulas &#40;8&#44;8&#37;&#41;&#44; rea&#231;&#227;o p&#243;rica &#40;19&#44;4&#37;&#41; e altera&#231;&#245;es vasculares &#40;21&#44;3&#37;&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; As subst&#226;ncias que mais se apresentaram com padr&#227;o p&#243;rico foram sulfato de n&#237;quel &#40;39&#44;5&#37;&#41; e cobalto &#40;28&#44;6&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">As altera&#231;&#245;es morfol&#243;gicas vasculares encontradas foram vasos puntiformes&#44; lineares&#44; polim&#243;rficos&#44; petequiais e n&#227;o caracterizados&#46; Em 21&#44;3&#37; dos casos foi poss&#237;vel caracterizar a morfologia vascular predominante&#44; a saber&#58; 6&#44;3&#37;&#160;vasos puntiformes&#59; 5&#37; vasos lineares&#59; 3&#44;1&#37;&#160;vasos polim&#243;rficos&#59; e 6&#44;9&#37; petequiais&#46; Nos demais casos &#40;quase&#160;79&#37;&#41; houve um predom&#237;nio do eritema de base&#44; sem diferencia&#231;&#227;o da morfologia vascular&#46; As imagens das rea&#231;&#245;es dos testes de contato&#44; de acordo com o ICDRG&#44; a olho nu e com a dermatoscopia&#44; est&#227;o apresentadas nas <a class="elsevierStyleCrossRefs" href="#fig0005">figuras 1 e 2</a>&#46; Al&#233;m disso&#44; &#233; importante ressaltar a import&#226;ncia da dermatoscopia na defini&#231;&#227;o do eritema nas rea&#231;&#245;es duvidosas&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es foram consideradas negativas&#44; &#224; dermatoscopia&#44; quando n&#227;o apresentavam &#225;rea de eritema difuso&#44; ainda que isoladamente estivessem presentes eritema perifolicular e crost&#237;culas foliculares&#46; As rea&#231;&#245;es duvidosas&#44; &#224; dermatoscopia&#44; foram consideradas aquelas em que a d&#250;vida da exist&#234;ncia de alguma &#225;rea de eritema n&#227;o folicular permaneceu &#40;&#224; semelhan&#231;a da avalia&#231;&#227;o a olho nu&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Dentre as 160 rea&#231;&#245;es presentes&#44; 28 &#40;17&#44;5&#37;&#41; foram fracas&#44; 49 &#40;30&#44;6&#37;&#41; foram fortes&#44; 47 &#40;29&#44;3&#37;&#41; foram muito fortes e 36 &#40;22&#44;5&#37;&#41; duvidosas&#46; Avaliando as&#160;36&#160;rea&#231;&#245;es duvidosas a olho nu&#44; 33&#160;&#40;91&#44;6&#37;&#41; tiveram mudan&#231;a do resultado final ap&#243;s a dermatoscopia &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#58; 17&#160;foram reclassificadas como rea&#231;&#245;es negativas e 16&#160;como rea&#231;&#245;es positivas fracas &#40;&#43;&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Diante do n&#250;mero relativamente pequeno de pacientes com hist&#243;ria pessoal de atopia&#44; n&#227;o foi poss&#237;vel relacionar essa vari&#225;vel com um padr&#227;o espec&#237;fico de achados dermatol&#243;gicos aos testes de contato&#44; em leitura final&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discuss&#227;o</span><p id="par0100" class="elsevierStylePara elsevierViewall">A dermatoscopia parece revelar importantes altera&#231;&#245;es quando utilizadas na interpreta&#231;&#227;o dos testes de contato&#44; na suspeita de DCA&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8&#44;17</span></a> Corazza et al&#46; avaliaram principalmente as diferen&#231;as entre rea&#231;&#245;es al&#233;rgicas e irritativas e observaram que o eritema &#233; o mais importante na diferencia&#231;&#227;o entre as rea&#231;&#245;es irritantes e as rea&#231;&#245;es al&#233;rgicas&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">O objetivo primordial desse estudo foi descrever os achados dermatosc&#243;picos observados na avalia&#231;&#227;o final das rea&#231;&#245;es dos testes de contato&#44; sob a suspeita de DAC&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Em testes com rea&#231;&#245;es fortes &#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; e muito fortes &#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#44; a dermatoscopia n&#227;o se mostrou ser decisiva para o diagn&#243;stico&#44; pois nesses casos as caracter&#237;sticas cl&#237;nicas s&#227;o evidentes e podem ser complementadas com a palpa&#231;&#227;o&#46; J&#225; nas rea&#231;&#245;es duvidosas e fracas&#44; a mesma pode ser &#250;til na melhoria da interpreta&#231;&#227;o dos resultados&#46; Das&#160;160&#160;rea&#231;&#245;es presentes&#44; 28&#160;&#40;17&#44;5&#37;&#41; foram fracas e 36&#160;&#40;22&#44;5&#37;&#41; duvidosas antes da dermatoscopia&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">A dermatoscopia permitiu melhor defini&#231;&#227;o do eritema&#44; levando &#224; reclassifica&#231;&#227;o das rea&#231;&#245;es duvidosas em 91&#44;6&#37; dos casos &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#37;&#41;&#44; alcan&#231;ando a positividade em 44&#44;4&#37; das rea&#231;&#245;es inicialmente classificadas como duvidosas&#44; e&#160;17&#160;rea&#231;&#245;es foram reclassificadas como negativas&#46; Ap&#243;s a dermatoscopia&#44; restaram apenas tr&#234;s rea&#231;&#245;es duvidosas &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#59; esses achados foram estatisticamente significativos&#46; Obviamente&#44; as rea&#231;&#245;es fracas &#40;&#43;&#41; podem ou n&#227;o ser consideradas relevantes clinicamente&#44; pois algumas rea&#231;&#245;es n&#227;o t&#234;m rela&#231;&#227;o com o quadro cl&#237;nico do paciente&#46; A dermatoscopia apenas &#233; um m&#233;todo a revelar uma situa&#231;&#227;o que poderia passar sem a percep&#231;&#227;o de um poss&#237;vel diagn&#243;stico&#59; desta forma persiste sendo fundamental a correla&#231;&#227;o entre o resultado dos testes e a investiga&#231;&#227;o cl&#237;nica &#40;anamnese e exame f&#237;sico&#41;&#46; A dermatoscopia parece proporcionar uma melhor avalia&#231;&#227;o dos testes em pacientes com fototipos altos e na avalia&#231;&#227;o de subst&#226;ncias com pigmento&#44; principalmente na revela&#231;&#227;o do eritema homog&#234;neo &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Diferentemente do estudo de Corazza et al&#46;&#44; n&#227;o visualizamos ves&#237;culas em rea&#231;&#245;es fracas&#44; mas foi um achado muito presente em rea&#231;&#245;es fortes e muito fortes&#44; que se caracterizaram por c&#237;rculos esbranqui&#231;ados de diferentes tamanhos&#44; lembrando &#8220;bolhas de sab&#227;o&#8221;&#44; como j&#225; descrito na literatura&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Sobre as caracter&#237;sticas dos vasos nas rea&#231;&#245;es al&#233;rgicas&#44; houve um predom&#237;nio de eritema difuso&#160;&#40;79&#37;&#41;&#44; em diferentes graus&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;16</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclus&#227;o</span><p id="par0125" class="elsevierStylePara elsevierViewall">Esse estudo demonstra que a dermatoscopia &#233; muito &#250;til na interpreta&#231;&#227;o de rea&#231;&#245;es fracas e&#44; principalmente&#44; nas rea&#231;&#245;es duvidosas&#44; assim como na melhor defini&#231;&#227;o do eritema de rea&#231;&#245;es em pacientes com fototipos&#160;IV&#160;e&#160;V e de subst&#226;ncias com dep&#243;sito de pigmento&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Suporte financeiro</span><p id="par0130" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Contribui&#231;&#227;o dos autores</span><p id="par0135" class="elsevierStylePara elsevierViewall">Kenselyn Oppermann&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Cristiane Almeida Soares Cattani&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Renan Rangel Bonamigo&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflito de interesses</span><p id="par0150" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Apesar de ser muito utilizada nas diversas &#225;reas da Dermatologia&#44; existem poucos estudos que avaliam o benef&#237;cio da dermatoscopia na interpreta&#231;&#227;o dos testes de contato&#44; principalmente nas rea&#231;&#245;es fracas e duvidosas&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar o papel da dermatoscopia na interpreta&#231;&#227;o dos testes de contato e descrever os principais achados observados nessas rea&#231;&#245;es&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Metodologia</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo prospectivo&#44; realizado em centros de refer&#234;ncia em Dermatologia no Sul do Brasil&#44; que avaliou os resultados finais de testes de contato realizados com aux&#237;lio da dermatoscopia&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos&#160;77&#160;pacientes e 160&#160;rea&#231;&#245;es&#46; As subst&#226;ncias mais prevalentes foram sulfato de n&#237;quel &#40;23&#44;8&#37;&#41;&#44; kathon CG &#40;9&#44;4&#37;&#41; e perfume mix &#40;8&#44;8&#37;&#41;&#46; Os principais achados dermatosc&#243;picos foram &#225;rea da rea&#231;&#227;o maior do que a metade da &#225;rea da c&#226;mara &#40;90&#37;&#41;&#44; eritema homog&#234;neo &#40;86&#44;9&#37;&#41;&#44; ves&#237;culas &#40;30&#37;&#41;&#44; crostas &#40;21&#44;3&#37;&#41;&#44; eritema perifolicular &#40;35&#37;&#41;&#44; rea&#231;&#227;o p&#243;rica &#40;19&#44;4&#37;&#41; e p&#250;stulas &#40;8&#44;8&#37;&#41;&#46; Verificou&#8208;se que a dermatoscopia facilita a defini&#231;&#227;o do eritema em rea&#231;&#245;es na pele negra e daquelas decorrentes de subst&#226;ncias com dep&#243;sito de pigmento&#46; Entre as 64 rea&#231;&#245;es fracas ou duvidosas&#44; 36 &#40;56&#44;25&#37;&#41; tiveram modifica&#231;&#227;o do resultado final ap&#243;s a dermatoscopia&#59; entre as 36 rea&#231;&#245;es duvidosas&#44; 33 &#40;91&#44;6&#37;&#41; tiveram mudan&#231;a do resultado final ap&#243;s a dermatoscopia &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#227;o do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Tamanho amostral&#44; pois ainda que determinadas signific&#226;ncias tenham sido atingidas&#44; outras poss&#237;veis rela&#231;&#245;es podem n&#227;o ter sido observadas&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A dermatoscopia melhora de forma relevante a resolu&#231;&#227;o diagn&#243;stica na interpreta&#231;&#227;o dos testes de contato&#44; especialmente em rea&#231;&#245;es fracas e duvidosas&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Como citar este artigo&#58; Oppermann K&#44; Cattani CA&#44; Bonamigo RR&#46; Usefulness of dermoscopy in the evaluation of patch test reactions&#46; An Bras Dermatol&#46; 2021&#59;96&#58;706&#8211;11&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Trabalho realizado no Ambulat&#243;rio de Dermatologia Sanit&#225;ria do Rio Grande do Sul&#47;Servi&#231;o de Dermatologia&#44; Hospital de Cl&#237;nicas de Porto Alegre&#44; Porto Alegre&#44; RS&#44; Brasil&#46;</p>"
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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Achados dermatosc&#243;picos dos testes de contato&#58; &#40;a&#41;&#44;&#160;Eritema homog&#234;neo&#59; &#40;b&#41;&#44;&#160;Eritema perifolicular &#40;seta&#41;&#59; &#40;c&#41;&#44; P&#225;pulas &#40;seta&#41;&#59; &#40;d&#41;&#44;&#160;Crostas&#59; &#40;e&#41;&#44; Ves&#237;culas&#59; &#40;f&#41;&#44;&#160;Acentua&#231;&#227;o folicular &#40;paciente at&#243;pico&#41;&#59; &#40;g&#41;&#44;&#160;Vasos lineares&#59; &#40;h&#41;&#44;&#160;Petequias &#40;seta&#41;&#59; &#40;i&#41;&#44;&#160;P&#250;stulas&#59; &#40;j&#41;&#44;&#160;Padr&#227;o p&#243;rico&#46;</p>"
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        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Testes de contato&#58; &#40;a1&#41;&#44;&#160;Rea&#231;&#227;o fraca&#160;&#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#59; &#40;a2&#41;&#44;&#160;Fraca&#160;&#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; com dermatoscopia&#59; &#40;b1&#41;&#44;&#160;Forte&#160;&#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#59; &#40;b2&#41;&#44; Forte&#160;&#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; com dermatoscopia&#59; &#40;c1&#41;&#44;&#160;Muito forte&#160;&#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#59; &#40;c2&#41;&#44;&#160;Muito forte&#160;&#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; &#224; dermatoscopia&#59; &#40;d1&#41;&#44;&#160;Rea&#231;&#227;o duvidosa a olho nu&#59; &#40;d2&#41;&#44;&#160;Rea&#231;&#227;o&#160;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#224; dermatoscopia&#46;</p>"
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        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Utilidade da dermatoscopia nos testes de contato que cont&#234;m pigmento&#58; &#40;a1&#41;&#44; Teste de parafenilenodiamina a olho nu&#44; com rea&#231;&#227;o duvidosa&#59; &#40;a2&#41;&#44; Teste de parafenilenodiamina com rea&#231;&#227;o fraca &#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; &#40;b1&#41;&#44;&#160;Paciente com fototipo V e rea&#231;&#227;o ao n&#237;quel a olho nu&#44; com leve eritema&#59; &#40;b2&#41;&#44; O mesmo paciente com dermatoscopia mostrando eritema bem definido e rea&#231;&#227;o p&#243;rica&#59; &#40;c1&#41;&#44;&#160;Rea&#231;&#227;o ao azul disperse a olho nu&#44; com rea&#231;&#227;o duvidosa&#59; &#40;c2&#41;&#44;&#160;Rea&#231;&#227;o ao azul disperse com a dermatoscopia evidenciando somente pigmento sem eritema &#40;rea&#231;&#227;o negativa&#41;&#59; &#40;d1&#160;e&#160;d2&#41;&#44;&#160;Teste com Parafenilenodiamina&#44; a olho nu e &#224; dermatoscopia&#44; demostrando somente pigmenta&#231;&#227;o sem eritema e rea&#231;&#227;o negativa&#46;</p>"
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                  \t\t\t\t"><span class="elsevierStyleBold">Idade &#40;anos&#41;</span> m&#233;dia &#40;m&#237;nima &#8211; m&#225;xima&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17 &#40;22&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12 &#40;15&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>VI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12 &#40;15&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16 &#40;20&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cosm&#233;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Rea&#231;&#245;es</span> &#40;n&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Subst&#226;ncias mais prevalentes&#44;</span> n &#40;&#37;&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sulfato de n&#237;quel&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;23&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Kathon CG &#40;isotiazolinona&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;9&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Perfume mix&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;8&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Parafenilenodiamina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neomicina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;5&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Thimerosal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#227;o &#40;&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>49&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#227;o &#40;&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;66&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">40 &#40;90&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">48 &#40;97&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eritema homog&#234;neo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;66&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;93&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;95&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">47 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Eritema perifolicular&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;38&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">8 &#40;17&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">P&#225;pulas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;50&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;76&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ves&#237;culas&#47;bolhas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;38&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;61&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">P&#250;stulas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;19&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Crostas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;12&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;55&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obstru&#231;&#227;o folicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;11&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;12&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;27&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acentua&#231;&#227;o folicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;11&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;8&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Altera&#231;&#245;es vasculares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso puntiforme&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;8&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso petequial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso polim&#243;rfico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso n&#227;o caracterizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;90&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;71&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;76&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2750893.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Achados dermatosc&#243;picos das rea&#231;&#245;es aos testes de contato na leitura de&#160;96&#160;horas</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados das rea&#231;&#245;es em 96 h<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Olho nu&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dermatoscopia&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fraca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;17&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;27&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Forte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;30&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;30&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Muito forte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;29&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;29&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duvidosa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;22&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativa&#47;irritativa<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;10&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2750891.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">De acordo com o Grupo Internacional de Estudo em Dermatite de Contato&#46;</p>"
            ]
            1 => array:3 [
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Artigo original
A utilidade da dermatoscopia na avaliação das reações aos testes de contato
Kenselyn Oppermanna,
Corresponding author
kenselyn@gmail.com

Autor para correspondência.
, Cristiane Almeida Soares Cattanib, Renan Rangel Bonamigoa,b,c
a Programa de Pós‐Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil
b Departamento de Saúde, Ambulatório de Dermatologia Sanitária de Porto Alegre, Porto Alegre, RS, Brasil
c Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
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mesmo seguindo crit&#233;rios de leitura internacionalmente aceitos&#44; h&#225; dificuldades para a conclus&#227;o de certos casos de suspeita de dermatite al&#233;rgica de contato &#40;DAC&#41;&#44; principalmente na diferencia&#231;&#227;o das rea&#231;&#245;es fracas e duvidosas&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Estabelecer qual o papel que a dermatoscopia pode exercer para melhorar a interpreta&#231;&#227;o dos testes de contato foi o objetivo do presente estudo&#44; assim como descrever os principais achados dermatosc&#243;picos das rea&#231;&#245;es&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Foi realizado estudo prospectivo com os pacientes encaminhados para teste de contato em dois servi&#231;os de refer&#234;ncia em dermatologia do Sul do Brasil&#44; o Ambulat&#243;rio de Dermatologia Sanit&#225;ria do Rio Grande do Sul e o Hospital de Cl&#237;nicas de Porto Alegre&#44; de novembro de&#160;2018 a dezembro de&#160;2019&#46; A pesquisa foi aprovada pelos respectivos Comit&#234;s de &#201;tica em Pesquisa&#44; n&#250;meros&#160;2&#46;952&#46;421&#44; 3&#46;032&#46;971&#44; 2&#46;990&#46;263&#44; assim como todos os participantes tiveram o termo de consentimento livre e esclarecido assinado&#44; de acordo com a declara&#231;&#227;o de Helsinki e da Resolu&#231;&#227;o do Conselho Nacional de Sa&#250;de de&#160;2012&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A dermatoscopia foi realizada na interpreta&#231;&#227;o dos testes realizados rotineiramente nos Servi&#231;os&#44; os quais utilizaram &#8211; de acordo com a indica&#231;&#227;o necess&#225;ria &#8211; a bateria padr&#227;o brasileira composta por&#160;30&#160;subst&#226;ncias ou uma bateria pedi&#225;trica&#44; composta por 20 subst&#226;ncias&#44; e uma bateria de cosm&#233;ticos&#44; composta por&#160;10&#160;subst&#226;ncias &#40;todas baterias elaboradas pela Asacpharma&#174;&#41;&#46; Todos os pacientes com rea&#231;&#245;es positivas ou duvidosas &#224; leitura de&#160;96&#160;horas &#40;segunda leitura ou leitura final&#41; foram inclu&#237;dos para avalia&#231;&#227;o dermatosc&#243;pica&#46; Os pacientes com testes negativos &#224; leitura de&#160;96&#160;horas foram exclu&#237;dos&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A avalia&#231;&#227;o &#40;leitura&#41; dos testes &#224;s&#160;96&#160;horas foi interpretada a olho nu &#40;por dermatologista <span class="elsevierStyleItalic">expert</span>&#160;&#8211;&#160;R&#46;R&#46;B&#46; e dermatologista pesquisadora&#160;&#8211;&#160;K&#46;O&#46;&#41;&#44; de acordo com os crit&#233;rios do International Contact Dermatitis Research Group &#40;ICDRG&#41;&#44; que seguem&#58; rea&#231;&#227;o duvidosa &#8211; algum eritema&#160;&#40;&#63;&#41;&#59; rea&#231;&#227;o leve &#8211; eritema definido&#44; leve infiltra&#231;&#227;o e p&#225;pulas eventuais&#160;&#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; rea&#231;&#227;o forte &#8211; eritema definido&#44; infiltra&#231;&#227;o&#44; p&#225;pulas e ves&#237;culas eventuais&#160;&#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; rea&#231;&#227;o muito forte &#8211; eritema intenso&#44; infiltra&#231;&#227;o e ves&#237;culas coalescentes &#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;15</span></a> Rea&#231;&#245;es duvidosas ou positivas em 48 horas e que tornaram&#8208;se negativas &#224; leitura a olho nu &#40;aus&#234;ncia de eritema&#41; em 96 horas&#44; foram classificadas como rea&#231;&#245;es irritativas&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A interpreta&#231;&#227;o dos testes de contato por meio da dermatoscopia foi realizada com aux&#237;lio de dermatosc&#243;pio Dermlite4 &#40;aumento de&#160;10&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#44; e as imagens das rea&#231;&#245;es foram registradas com <span class="elsevierStyleItalic">Handyscope FotoFinder</span>&#174; &#40;aumento de 20&#215;<span class="elsevierStyleHsp" style=""></span>&#41; e FotoFinder&#174; &#40;aumento de 40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#41;&#44; com camada espessa de gel de interface e m&#237;nima press&#227;o&#46; As imagens dermatosc&#243;picas foram obtidas pela dermatologista pesquisadora &#40;K&#46;O&#46;&#41; e avaliadas por R&#46;R&#46;B&#46; e K&#46;O&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Os resultados obtidos pela avalia&#231;&#227;o dermatosc&#243;pica envolveram as vari&#225;veis a seguir&#58; &#8208; &#193;rea total de acometimento da pele no local da c&#226;mara&#58; at&#233;&#160;50&#37; ou maior de&#160;50&#37;&#59; &#8208; Eritema homog&#234;neo&#58; eritema difuso na maior parte da &#225;rea da c&#226;mara&#59; &#8208; Eritema perifolicular&#58; eritema essencialmente em torno dos &#243;stios foliculares&#59; &#8208; P&#225;pulas &#8211; &#225;reas mais claras simulando um v&#233;u&#44; mal&#8208;delimitadas&#59; &#8208; Ves&#237;culas&#47;bolhas &#8211; c&#237;rculos esbranqui&#231;ados de diferentes tamanhos que lembram bolhas de sab&#227;o&#59; &#8208; P&#250;stulas&#58; c&#237;rculos amarelados&#59; &#8208; Crostas&#58; material s&#243;lido e aderido proveniente de ressecamento de l&#237;quido&#59; &#8208; Rea&#231;&#227;o p&#243;rica &#40;ou obstru&#231;&#227;o folicular&#41;&#58; padr&#227;o de rea&#231;&#227;o folicular&#44; podendo ser pigmento amarronzado ou forma&#231;&#227;o de crost&#237;culas nos &#243;stios foliculares&#59; &#8208; Acentua&#231;&#227;o folicular&#58; m&#250;ltiplos pequenos pontos branco&#8208;acinzentados do mesmo tamanho&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">As altera&#231;&#245;es vasculares foram classificadas em&#58; &#8208; Vasos puntiformes&#58; pequenos pontos&#59; &#8208; Lineares&#59; &#8208; Polim&#243;rficos&#58; quando n&#227;o seguem um padr&#227;o e se apresentam com mais de uma forma&#59; &#8208; Pet&#233;quias&#58; colora&#231;&#227;o purp&#250;rica que n&#227;o desaparece &#224; vitropress&#227;o&#46; Esses crit&#233;rios foram escolhidos a partir de estudos previamente publicados e adaptados de acordo com a experi&#234;ncia dos autores&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8&#44;16&#44;17</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es al&#233;rgicas t&#234;m como principais caracter&#237;sticas dermatosc&#243;picas o eritema homog&#234;neo e difuso&#44; envolvendo ou n&#227;o a &#225;rea folicular&#44; as p&#225;pulas e as forma&#231;&#245;es l&#237;quidas&#46; H&#225; a possibilidade de um conjunto de modifica&#231;&#245;es acess&#243;rias e secund&#225;rias como crostas&#44; rea&#231;&#227;o p&#243;rica e acentua&#231;&#227;o folicular&#59; por&#233;m esses achados isoladamente&#44; sem a forma&#231;&#227;o de eritema homog&#234;neo &#40;com ou sem p&#225;pulas e forma&#231;&#245;es l&#237;quidas&#41;&#44; n&#227;o se configuram em rea&#231;&#245;es do tipo al&#233;rgicas&#46; As altera&#231;&#245;es vasculares s&#227;o achados acess&#243;rios&#44; tamb&#233;m&#44; a serem mais explorados&#44; como neste estudo&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es irritativas n&#227;o foram consideradas especificamente na an&#225;lise&#44; pois o objetivo era avaliar as rea&#231;&#245;es que permaneceram com eritema nas 96 horas&#44; mas &#233; importante citar que as caracter&#237;sticas dermatosc&#243;picas das rea&#231;&#245;es irritativas s&#227;o descritas como rea&#231;&#227;o p&#243;rica e&#47;ou rea&#231;&#227;o perifolicular&#44; na aus&#234;ncia do eritema homog&#234;neo de base&#46; Igualmente ao que ocorre com nas rea&#231;&#245;es al&#233;rgicas&#44; n&#227;o h&#225; um definido padr&#227;o de altera&#231;&#245;es vasculares espec&#237;ficos para as rea&#231;&#245;es irritativas&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8&#44;17</span></a> Neste estudo&#44; os resultados com rea&#231;&#245;es irritativas foram considerados negativos para DAC&#44; ap&#243;s a dermatoscopia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">As informa&#231;&#245;es coletadas foram digitadas em base de dados no programa Microsoft Excel&#44; processados e analisados com aux&#237;lio do programa SPSS vers&#227;o&#160;25&#46; Os dados foram apresentados por meio de frequ&#234;ncias e percentuais&#44; e a idade por m&#233;dia e desvio&#8208;padr&#227;o&#46; As associa&#231;&#245;es foram verificadas por meio do teste Qui&#8208;Quadrado ou teste Exato de Fisher&#44; quando adequado&#46; O resultado antes foi comparado com o depois&#44; pel teste McNemmar&#46; Foram considerados resultados significativos quando&#160;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="par0065" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos&#160;77&#160;pacientes&#44; em um total de&#160;160&#160;rea&#231;&#245;es&#46; Verifica&#8208;se que a maioria da amostra foi composta por mulheres &#40;77&#44;9&#37;&#41;&#44; com ampla variabilidade et&#225;ria e de fototipos&#44; e hist&#243;ria pessoal de atopia em&#160;15&#44;6&#37; dos pacientes&#44; A maioria foi testada com a bateria padr&#227;o &#40;76&#44;6&#37;&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">As subst&#226;ncias mais prevalentes foram o sulfato de n&#237;quel &#40;23&#44;8&#37;&#41;&#44; o grupo das isotiazolinonas &#8211; &#8220;Kathon CG&#8221; &#40;9&#44;4&#37;&#41; e o grupo de perfumes &#8211; &#8220;Perfume&#8208;mix&#8221; &#40;8&#44;8&#37;&#41;&#46; As caracter&#237;sticas gerais dos pacientes que foram submetidos &#224; leitura dos testes de contato com a dermatoscopia est&#227;o descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Os principais achados dermatosc&#243;picos dos pacientes com DCA foram &#225;rea da rea&#231;&#227;o maior do que a metade do local da c&#226;mara &#40;90&#37;&#41;&#44; eritema homog&#234;neo &#40;86&#44;9&#37;&#41;&#44; ves&#237;culas &#40;30&#37;&#41;&#44; crostas &#40;21&#44;3&#37;&#41;&#44; eritema perifolicular &#40;35&#37;&#41;&#44; p&#250;stulas &#40;8&#44;8&#37;&#41;&#44; rea&#231;&#227;o p&#243;rica &#40;19&#44;4&#37;&#41; e altera&#231;&#245;es vasculares &#40;21&#44;3&#37;&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; As subst&#226;ncias que mais se apresentaram com padr&#227;o p&#243;rico foram sulfato de n&#237;quel &#40;39&#44;5&#37;&#41; e cobalto &#40;28&#44;6&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">As altera&#231;&#245;es morfol&#243;gicas vasculares encontradas foram vasos puntiformes&#44; lineares&#44; polim&#243;rficos&#44; petequiais e n&#227;o caracterizados&#46; Em 21&#44;3&#37; dos casos foi poss&#237;vel caracterizar a morfologia vascular predominante&#44; a saber&#58; 6&#44;3&#37;&#160;vasos puntiformes&#59; 5&#37; vasos lineares&#59; 3&#44;1&#37;&#160;vasos polim&#243;rficos&#59; e 6&#44;9&#37; petequiais&#46; Nos demais casos &#40;quase&#160;79&#37;&#41; houve um predom&#237;nio do eritema de base&#44; sem diferencia&#231;&#227;o da morfologia vascular&#46; As imagens das rea&#231;&#245;es dos testes de contato&#44; de acordo com o ICDRG&#44; a olho nu e com a dermatoscopia&#44; est&#227;o apresentadas nas <a class="elsevierStyleCrossRefs" href="#fig0005">figuras 1 e 2</a>&#46; Al&#233;m disso&#44; &#233; importante ressaltar a import&#226;ncia da dermatoscopia na defini&#231;&#227;o do eritema nas rea&#231;&#245;es duvidosas&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">As rea&#231;&#245;es foram consideradas negativas&#44; &#224; dermatoscopia&#44; quando n&#227;o apresentavam &#225;rea de eritema difuso&#44; ainda que isoladamente estivessem presentes eritema perifolicular e crost&#237;culas foliculares&#46; As rea&#231;&#245;es duvidosas&#44; &#224; dermatoscopia&#44; foram consideradas aquelas em que a d&#250;vida da exist&#234;ncia de alguma &#225;rea de eritema n&#227;o folicular permaneceu &#40;&#224; semelhan&#231;a da avalia&#231;&#227;o a olho nu&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Dentre as 160 rea&#231;&#245;es presentes&#44; 28 &#40;17&#44;5&#37;&#41; foram fracas&#44; 49 &#40;30&#44;6&#37;&#41; foram fortes&#44; 47 &#40;29&#44;3&#37;&#41; foram muito fortes e 36 &#40;22&#44;5&#37;&#41; duvidosas&#46; Avaliando as&#160;36&#160;rea&#231;&#245;es duvidosas a olho nu&#44; 33&#160;&#40;91&#44;6&#37;&#41; tiveram mudan&#231;a do resultado final ap&#243;s a dermatoscopia &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#58; 17&#160;foram reclassificadas como rea&#231;&#245;es negativas e 16&#160;como rea&#231;&#245;es positivas fracas &#40;&#43;&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Diante do n&#250;mero relativamente pequeno de pacientes com hist&#243;ria pessoal de atopia&#44; n&#227;o foi poss&#237;vel relacionar essa vari&#225;vel com um padr&#227;o espec&#237;fico de achados dermatol&#243;gicos aos testes de contato&#44; em leitura final&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discuss&#227;o</span><p id="par0100" class="elsevierStylePara elsevierViewall">A dermatoscopia parece revelar importantes altera&#231;&#245;es quando utilizadas na interpreta&#231;&#227;o dos testes de contato&#44; na suspeita de DCA&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8&#44;17</span></a> Corazza et al&#46; avaliaram principalmente as diferen&#231;as entre rea&#231;&#245;es al&#233;rgicas e irritativas e observaram que o eritema &#233; o mais importante na diferencia&#231;&#227;o entre as rea&#231;&#245;es irritantes e as rea&#231;&#245;es al&#233;rgicas&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">O objetivo primordial desse estudo foi descrever os achados dermatosc&#243;picos observados na avalia&#231;&#227;o final das rea&#231;&#245;es dos testes de contato&#44; sob a suspeita de DAC&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Em testes com rea&#231;&#245;es fortes &#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; e muito fortes &#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#44; a dermatoscopia n&#227;o se mostrou ser decisiva para o diagn&#243;stico&#44; pois nesses casos as caracter&#237;sticas cl&#237;nicas s&#227;o evidentes e podem ser complementadas com a palpa&#231;&#227;o&#46; J&#225; nas rea&#231;&#245;es duvidosas e fracas&#44; a mesma pode ser &#250;til na melhoria da interpreta&#231;&#227;o dos resultados&#46; Das&#160;160&#160;rea&#231;&#245;es presentes&#44; 28&#160;&#40;17&#44;5&#37;&#41; foram fracas e 36&#160;&#40;22&#44;5&#37;&#41; duvidosas antes da dermatoscopia&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">A dermatoscopia permitiu melhor defini&#231;&#227;o do eritema&#44; levando &#224; reclassifica&#231;&#227;o das rea&#231;&#245;es duvidosas em 91&#44;6&#37; dos casos &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#37;&#41;&#44; alcan&#231;ando a positividade em 44&#44;4&#37; das rea&#231;&#245;es inicialmente classificadas como duvidosas&#44; e&#160;17&#160;rea&#231;&#245;es foram reclassificadas como negativas&#46; Ap&#243;s a dermatoscopia&#44; restaram apenas tr&#234;s rea&#231;&#245;es duvidosas &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#59; esses achados foram estatisticamente significativos&#46; Obviamente&#44; as rea&#231;&#245;es fracas &#40;&#43;&#41; podem ou n&#227;o ser consideradas relevantes clinicamente&#44; pois algumas rea&#231;&#245;es n&#227;o t&#234;m rela&#231;&#227;o com o quadro cl&#237;nico do paciente&#46; A dermatoscopia apenas &#233; um m&#233;todo a revelar uma situa&#231;&#227;o que poderia passar sem a percep&#231;&#227;o de um poss&#237;vel diagn&#243;stico&#59; desta forma persiste sendo fundamental a correla&#231;&#227;o entre o resultado dos testes e a investiga&#231;&#227;o cl&#237;nica &#40;anamnese e exame f&#237;sico&#41;&#46; A dermatoscopia parece proporcionar uma melhor avalia&#231;&#227;o dos testes em pacientes com fototipos altos e na avalia&#231;&#227;o de subst&#226;ncias com pigmento&#44; principalmente na revela&#231;&#227;o do eritema homog&#234;neo &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Diferentemente do estudo de Corazza et al&#46;&#44; n&#227;o visualizamos ves&#237;culas em rea&#231;&#245;es fracas&#44; mas foi um achado muito presente em rea&#231;&#245;es fortes e muito fortes&#44; que se caracterizaram por c&#237;rculos esbranqui&#231;ados de diferentes tamanhos&#44; lembrando &#8220;bolhas de sab&#227;o&#8221;&#44; como j&#225; descrito na literatura&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Sobre as caracter&#237;sticas dos vasos nas rea&#231;&#245;es al&#233;rgicas&#44; houve um predom&#237;nio de eritema difuso&#160;&#40;79&#37;&#41;&#44; em diferentes graus&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;16</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclus&#227;o</span><p id="par0125" class="elsevierStylePara elsevierViewall">Esse estudo demonstra que a dermatoscopia &#233; muito &#250;til na interpreta&#231;&#227;o de rea&#231;&#245;es fracas e&#44; principalmente&#44; nas rea&#231;&#245;es duvidosas&#44; assim como na melhor defini&#231;&#227;o do eritema de rea&#231;&#245;es em pacientes com fototipos&#160;IV&#160;e&#160;V e de subst&#226;ncias com dep&#243;sito de pigmento&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Suporte financeiro</span><p id="par0130" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Contribui&#231;&#227;o dos autores</span><p id="par0135" class="elsevierStylePara elsevierViewall">Kenselyn Oppermann&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Cristiane Almeida Soares Cattani&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Renan Rangel Bonamigo&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#59; participa&#231;&#227;o intelectual em conduta proped&#234;utica e&#47;ou terap&#234;utica de casos estudados&#59; revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflito de interesses</span><p id="par0150" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Apesar de ser muito utilizada nas diversas &#225;reas da Dermatologia&#44; existem poucos estudos que avaliam o benef&#237;cio da dermatoscopia na interpreta&#231;&#227;o dos testes de contato&#44; principalmente nas rea&#231;&#245;es fracas e duvidosas&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar o papel da dermatoscopia na interpreta&#231;&#227;o dos testes de contato e descrever os principais achados observados nessas rea&#231;&#245;es&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Metodologia</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo prospectivo&#44; realizado em centros de refer&#234;ncia em Dermatologia no Sul do Brasil&#44; que avaliou os resultados finais de testes de contato realizados com aux&#237;lio da dermatoscopia&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos&#160;77&#160;pacientes e 160&#160;rea&#231;&#245;es&#46; As subst&#226;ncias mais prevalentes foram sulfato de n&#237;quel &#40;23&#44;8&#37;&#41;&#44; kathon CG &#40;9&#44;4&#37;&#41; e perfume mix &#40;8&#44;8&#37;&#41;&#46; Os principais achados dermatosc&#243;picos foram &#225;rea da rea&#231;&#227;o maior do que a metade da &#225;rea da c&#226;mara &#40;90&#37;&#41;&#44; eritema homog&#234;neo &#40;86&#44;9&#37;&#41;&#44; ves&#237;culas &#40;30&#37;&#41;&#44; crostas &#40;21&#44;3&#37;&#41;&#44; eritema perifolicular &#40;35&#37;&#41;&#44; rea&#231;&#227;o p&#243;rica &#40;19&#44;4&#37;&#41; e p&#250;stulas &#40;8&#44;8&#37;&#41;&#46; Verificou&#8208;se que a dermatoscopia facilita a defini&#231;&#227;o do eritema em rea&#231;&#245;es na pele negra e daquelas decorrentes de subst&#226;ncias com dep&#243;sito de pigmento&#46; Entre as 64 rea&#231;&#245;es fracas ou duvidosas&#44; 36 &#40;56&#44;25&#37;&#41; tiveram modifica&#231;&#227;o do resultado final ap&#243;s a dermatoscopia&#59; entre as 36 rea&#231;&#245;es duvidosas&#44; 33 &#40;91&#44;6&#37;&#41; tiveram mudan&#231;a do resultado final ap&#243;s a dermatoscopia &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#227;o do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Tamanho amostral&#44; pois ainda que determinadas signific&#226;ncias tenham sido atingidas&#44; outras poss&#237;veis rela&#231;&#245;es podem n&#227;o ter sido observadas&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclus&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A dermatoscopia melhora de forma relevante a resolu&#231;&#227;o diagn&#243;stica na interpreta&#231;&#227;o dos testes de contato&#44; especialmente em rea&#231;&#245;es fracas e duvidosas&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Como citar este artigo&#58; Oppermann K&#44; Cattani CA&#44; Bonamigo RR&#46; Usefulness of dermoscopy in the evaluation of patch test reactions&#46; An Bras Dermatol&#46; 2021&#59;96&#58;706&#8211;11&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Trabalho realizado no Ambulat&#243;rio de Dermatologia Sanit&#225;ria do Rio Grande do Sul&#47;Servi&#231;o de Dermatologia&#44; Hospital de Cl&#237;nicas de Porto Alegre&#44; Porto Alegre&#44; RS&#44; Brasil&#46;</p>"
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          "pt" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Achados dermatosc&#243;picos dos testes de contato&#58; &#40;a&#41;&#44;&#160;Eritema homog&#234;neo&#59; &#40;b&#41;&#44;&#160;Eritema perifolicular &#40;seta&#41;&#59; &#40;c&#41;&#44; P&#225;pulas &#40;seta&#41;&#59; &#40;d&#41;&#44;&#160;Crostas&#59; &#40;e&#41;&#44; Ves&#237;culas&#59; &#40;f&#41;&#44;&#160;Acentua&#231;&#227;o folicular &#40;paciente at&#243;pico&#41;&#59; &#40;g&#41;&#44;&#160;Vasos lineares&#59; &#40;h&#41;&#44;&#160;Petequias &#40;seta&#41;&#59; &#40;i&#41;&#44;&#160;P&#250;stulas&#59; &#40;j&#41;&#44;&#160;Padr&#227;o p&#243;rico&#46;</p>"
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        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Testes de contato&#58; &#40;a1&#41;&#44;&#160;Rea&#231;&#227;o fraca&#160;&#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#59; &#40;a2&#41;&#44;&#160;Fraca&#160;&#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; com dermatoscopia&#59; &#40;b1&#41;&#44;&#160;Forte&#160;&#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#59; &#40;b2&#41;&#44; Forte&#160;&#40;2<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; com dermatoscopia&#59; &#40;c1&#41;&#44;&#160;Muito forte&#160;&#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; a olho nu&#59; &#40;c2&#41;&#44;&#160;Muito forte&#160;&#40;3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; &#224; dermatoscopia&#59; &#40;d1&#41;&#44;&#160;Rea&#231;&#227;o duvidosa a olho nu&#59; &#40;d2&#41;&#44;&#160;Rea&#231;&#227;o&#160;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#224; dermatoscopia&#46;</p>"
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        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Utilidade da dermatoscopia nos testes de contato que cont&#234;m pigmento&#58; &#40;a1&#41;&#44; Teste de parafenilenodiamina a olho nu&#44; com rea&#231;&#227;o duvidosa&#59; &#40;a2&#41;&#44; Teste de parafenilenodiamina com rea&#231;&#227;o fraca &#40;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41;&#59; &#40;b1&#41;&#44;&#160;Paciente com fototipo V e rea&#231;&#227;o ao n&#237;quel a olho nu&#44; com leve eritema&#59; &#40;b2&#41;&#44; O mesmo paciente com dermatoscopia mostrando eritema bem definido e rea&#231;&#227;o p&#243;rica&#59; &#40;c1&#41;&#44;&#160;Rea&#231;&#227;o ao azul disperse a olho nu&#44; com rea&#231;&#227;o duvidosa&#59; &#40;c2&#41;&#44;&#160;Rea&#231;&#227;o ao azul disperse com a dermatoscopia evidenciando somente pigmento sem eritema &#40;rea&#231;&#227;o negativa&#41;&#59; &#40;d1&#160;e&#160;d2&#41;&#44;&#160;Teste com Parafenilenodiamina&#44; a olho nu e &#224; dermatoscopia&#44; demostrando somente pigmenta&#231;&#227;o sem eritema e rea&#231;&#227;o negativa&#46;</p>"
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                  \t\t\t\t"><span class="elsevierStyleBold">Idade &#40;anos&#41;</span> m&#233;dia &#40;m&#237;nima &#8211; m&#225;xima&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17 &#40;22&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12 &#40;15&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>VI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12 &#40;15&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16 &#40;20&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cosm&#233;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Rea&#231;&#245;es</span> &#40;n&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Subst&#226;ncias mais prevalentes&#44;</span> n &#40;&#37;&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sulfato de n&#237;quel&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;23&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Kathon CG &#40;isotiazolinona&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;9&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Perfume mix&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;8&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Parafenilenodiamina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neomicina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;5&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Thimerosal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#227;o &#40;&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>49&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#227;o &#40;&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;66&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">40 &#40;90&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">48 &#40;97&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eritema homog&#234;neo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;66&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;93&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;95&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">47 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Eritema perifolicular&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;38&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">8 &#40;17&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">P&#225;pulas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;50&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;76&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ves&#237;culas&#47;bolhas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;38&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;61&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">P&#250;stulas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;19&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Crostas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;12&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;55&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obstru&#231;&#227;o folicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;11&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;12&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;27&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acentua&#231;&#227;o folicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;11&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;8&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Altera&#231;&#245;es vasculares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso puntiforme&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;8&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso petequial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso polim&#243;rfico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaso n&#227;o caracterizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;90&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;71&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;76&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2750893.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Achados dermatosc&#243;picos das rea&#231;&#245;es aos testes de contato na leitura de&#160;96&#160;horas</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados das rea&#231;&#245;es em 96 h<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Olho nu&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dermatoscopia&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fraca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;17&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;27&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Forte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;30&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;30&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Muito forte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;29&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;29&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duvidosa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;22&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativa&#47;irritativa<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;10&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2750891.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">De acordo com o Grupo Internacional de Estudo em Dermatite de Contato&#46;</p>"
            ]
            1 => array:3 [
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Article information
ISSN: 26662752
Original language: Portuguese
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2022 July 89 58 147
2022 June 100 71 171
2022 May 77 52 129
2022 April 125 82 207
2022 March 80 103 183
2022 February 42 49 91
2022 January 112 121 233
2021 December 96 97 193
2021 November 95 80 175
2021 October 28 46 74
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