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no per&#237;odo entre janeiro e abril de 2019&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Um question&#225;rio foi aplicado aos pacientes com UC e a pessoas sadias&#44; sobre eventos adversos &#224; imuniza&#231;&#227;o 30 dias ap&#243;s a vacina&#231;&#227;o&#44; e outro question&#225;rio para os doentes com UC que n&#227;o receberam a imuniza&#231;&#227;o&#44; a fim de se conhecer a motiva&#231;&#227;o que os levaram a n&#227;o receber a VFA&#46; Foram exclu&#237;dos os doentes que n&#227;o concordaram em participar do trabalho e assinar o termo de consentimento livre e esclarecido&#46; O estudo foi aprovado pelo Comit&#234; de &#201;tica em Pesquisa da institui&#231;&#227;o sob o n&#176; 2&#46;853&#46;158&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Os pacientes foram divididos nos seguintes grupos&#58; &#40;Grupo I&#41; 48 pacientes com UC em uso ou n&#227;o de omalizumabe&#47;anti&#8208;histam&#237;nico que receberam a VFA&#44; &#40;grupo III&#41; 41 pacientes com UC que n&#227;o receberam a VFA e &#40;grupo IIA&#41; 30 indiv&#237;duos normais &#40;sadios&#41; que fizeram uso da VFA &#40;grupo A&#41;&#46; No grupo I&#44; 48 indiv&#237;duos receberam a VFA &#8211; 30 deles estavam em uso de omalizumabe &#40;grupo B&#41;&#44; e 18 n&#227;o utilizavam omalizumabe &#40;grupo C&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">As vari&#225;veis qualitativas foram apresentadas por frequ&#234;ncia absoluta e frequ&#234;ncia relativa&#44; e as vari&#225;veis quantitativas foram apresentadas por m&#233;dia&#44; desvio&#8208;padr&#227;o&#44; valores m&#225;ximo e m&#237;nimo&#44; mediante teste de normalidade dos dados de Shapiro&#8208;Wilk &#40;p<span class="elsevierStyleHsp" style=""></span>&#62; 0&#44;05&#41;&#46; Para comparar as vari&#225;veis qualitativas foi utilizado o teste exato de Fischer&#46; Para todas as an&#225;lises&#44; o n&#237;vel de signific&#226;ncia adotado foi &#945;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; O programa estat&#237;stico utilizado foi Stata vers&#227;o 1&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Foram aplicados question&#225;rios aos 89 pacientes com UC&#44; e aos 30 indiv&#237;duos sadios que receberam a VFA &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> est&#227;o os resultados dos dados demogr&#225;ficos&#44; subtipos de UC e tratamento dos pacientes inclu&#237;dos no estudo no per&#237;odo entre janeiro e abril de 2019&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Dos pacientes com UC&#44; 48 &#40;53&#44;93&#37;&#41; receberam a VFA concomitante ao tratamento e 41 &#40;46&#44;07&#37;&#41; n&#227;o a receberam&#46; Todos os 48 pacientes que tomaram a VFA responderam ao question&#225;rio sobre rea&#231;&#245;es adversas&#46; A maioria dos pacientes &#40;89&#44;58&#37;&#41; n&#227;o referiu nenhuma rea&#231;&#227;o adversa &#224; vacina&#44; em concomit&#226;ncia com o tratamento com o omalizamabe&#46; Foram relatados tr&#234;s &#40;6&#44;25&#37;&#41; casos com rea&#231;&#227;o local &#224; aplica&#231;&#227;o da VFA&#44; um &#40;2&#44;08&#37;&#41; de astenia e um &#40;2&#44;08&#37;&#41; com exacerba&#231;&#227;o da doen&#231;a apresentando angioedema&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ao grupo de pacientes com UC que respondeu n&#227;o ter tomado voluntariamente a VFA&#44; a maioria &#40;31&#44;71&#37;&#41; n&#227;o procurou a imuniza&#231;&#227;o em virtude de j&#225; ter sido imunizado anteriormente ao tratamento da UC&#59; 26&#44;83&#37; referiram &#8220;Foi informado que n&#227;o deveria tomar por causa do tratamento por outro profissional da sa&#250;de&#8221;&#59; 21&#44;95&#37; referiram &#8220;Decidiu n&#227;o tomar&#8221;&#59; 12&#44;20&#37; tiveram &#8220;Receio de tomar a vacina devido &#224; doen&#231;a&#8221;&#46; Os demais pacientes responderam ao question&#225;rio com as seguintes afirma&#231;&#245;es&#58; &#8220;N&#227;o teve tempo&#44; orientado a n&#227;o tomar a vacina por causa de cirurgia bari&#225;trica&#8221; e &#8220;Orientada a n&#227;o tomar a vacina devido &#224; gravidez&#8221; &#8211; cada resposta destas compreendeu 2&#44;44&#37; das respostas&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> encontram&#8208;se descritos os eventos adversos em 30 indiv&#237;duos sadios&#44; 30 doentes com UC tratados com omalizumabe e 18 doentes com UC sem uso de omalizumabe&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">A an&#225;lise estat&#237;stica&#44; utilizando o teste exato de Fischer&#44; n&#227;o demonstrou diferen&#231;as entre a presen&#231;a ou n&#227;o de rea&#231;&#245;es adversas entre os grupos A &#40;indiv&#237;duos sadios&#41;&#44; B &#40;doentes com UC tratados com omalizumabe&#41; e C &#40;doentes com UC sem uso de omalizumabe&#41;&#44; com p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;553&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">N&#227;o h&#225; relatos na literatura a respeito do uso de omalizumabe concomitante &#224; imuniza&#231;&#227;o contra a FA&#46; A imuniza&#231;&#227;o contra a FA nos pacientes com UC em uso de omalizumabe foi aconselhada&#44; pois as rea&#231;&#245;es mediadas pela IgE&#44; nos mast&#243;citos e bas&#243;filos&#44; n&#227;o s&#227;o cruciais ao combate de infec&#231;&#245;es virais&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Apenas tr&#234;s pacientes &#40;6&#44;25&#37;&#41; mencionaram rea&#231;&#227;o cut&#226;nea no local da aplica&#231;&#227;o da vacina&#46; A frequ&#234;ncia desse evento &#233; de 4&#37; na popula&#231;&#227;o que recebe a VFA&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Um indiv&#237;duo &#40;2&#44;08&#37;&#41; referiu astenia&#46; A ocorr&#234;ncia de manifesta&#231;&#227;o sist&#234;mica &#233; de 1&#37; a 6&#37; dos indiv&#237;duos&#46; Por fim&#44; um paciente &#40;2&#44;08&#37;&#41; referiu exacerba&#231;&#227;o do angioedema ao tomar a vacina&#44; o que pode estar ligado tanto a uma poss&#237;vel rea&#231;&#227;o &#224; VFA quanto &#224; flutua&#231;&#227;o na atividade do controle da urtic&#225;ria em tratamento&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Comparando&#8208;se os grupos doentes em uso do omalizumabe que tomaram a VFA e doentes com UC sem omalizumabe que tomaram a VFA&#44; n&#227;o houve diferen&#231;a estat&#237;stica&#46; No grupo controle das 30 pessoas sadias comparando&#8208;se aos 30 doentes com UC que faziam uso do omalizumabe e tomaram a VFA tamb&#233;m n&#227;o se observou diferen&#231;a estat&#237;stica em rela&#231;&#227;o aos efeitos adversos&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Nosso estudo mostrou que os doentes com UC em tratamento com anti&#8208;histam&#237;nicos e&#47;ou omalizumabe n&#227;o referiram eventos adversos ap&#243;s a imuniza&#231;&#227;o contra a FA&#44; quando comparados aos indiv&#237;duos sadios&#44; sem UC&#44; que receberam a imuniza&#231;&#227;o no mesmo per&#237;odo&#44; com a mesma vacina fornecida pelo Minist&#233;rio da Sa&#250;de do Brasil&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0085" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0090" class="elsevierStylePara elsevierViewall">Laura Ramos de Almeida&#58; An&#225;lise estat&#237;stica&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Roberta Fachini Criado&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Paulo Ricardo Criado&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Luis Felipe Ensina&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Beatrice Martinez Zugaib Abdalla&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Juarez Ant&#244;nio Sim&#245;es Quaresma&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; revis&#227;o cr&#237;tica da literatura&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0120" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">G&#234;nero</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16&#44;85&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">83&#44;15&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="3" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>UCE&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">71&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">79&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>UCindu&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>UCE &#43; UCind&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">15&#44;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">70&#44;79&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">28&#44;09&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Uso de omalizumabe</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">39&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tomou a vacina de febre amarela&#63;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">53&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dados demogr&#225;ficos&#44; tipo de urtic&#225;ria&#44; uso do omalizumabe e imuniza&#231;&#227;o contra a febre amarela entre os 89 doentes com urtic&#225;ria participantes do estudo</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Grupos de indiv&#237;duos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t  " colspan="5" align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#245;es adversas atribu&#237;das &#224; vacina contra febre amarela</th><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#227;o cut&#226;nea local&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Astenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Exacerba&#231;&#227;o do angioedema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Febre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Grupo A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25 &#40;83&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;10&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;6&#44;67&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grupo B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;90&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grupo C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;88&#44;89&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;11&#44;11&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">68 &#40;87&#44;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;7&#44;69&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;1&#44;28&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;1&#44;28&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;56&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "pt" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Compara&#231;&#227;o entre o relato de rea&#231;&#245;es adversas atribu&#237;das &#224; vacina&#231;&#227;o contra a febre amarela&#44; entre indiv&#237;duos sadios &#40;grupo A&#41;&#44; doentes com urtic&#225;ria cr&#244;nica tratados com omalizumabe &#40;grupo B&#41; doentes com urtic&#225;ria cr&#244;nica sem uso de omalizumabe &#40;grupo C&#41;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => """
                    Brasil&#46; Minist&#233;rio da Sa&#250;de&#46; Minist&#233;rio da Sa&#250;de divulga balan&#231;o de um ano da febre amarela &#91;Internet&#93;&#46; 2018 Dez&#46; 8 &#91;cited 2018 Dez 27&#93;&#46; Dispon&#237;vel em&#58; \n
                    <https: www.gov.br="" aude="" t&#8208;br="" ssuntos="" oticias="" inisterio&#8208;da&#8208;saude&#8208;divulga&#8208;balanco&#8208;de&#8208;um&#8208;ano&#8208;da&#8208;febre&#8208;amarela="">\n
                     &#46;\n
                    </https:>
                    """
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic urticaria in adults&#58; state&#8208;of&#8208;the&#8208;art in the new millennium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;R&#46; Criado"
                            1 => "R&#46;F&#46;J&#46; Criado"
                            2 => "C&#46;W&#46; Maruta"
                            3 => "V&#46;M&#46;S&#46; Reis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/abd1806-4841.20153509"
                      "Revista" => array:6 [
                        "tituloSerie" => "An Bras Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "90"
                        "paginaInicial" => "74"
                        "paginaFinal" => "89"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25672302"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
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            2 => array:3 [
              "identificador" => "bib0045"
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Carta ‐ Investigação
Eventos adversos da vacina da febre amarela em pacientes com urticária crônica: avaliação de doentes tratados com e sem omalizumabe e controles sadios
Laura Ramos de Almeidaa, Roberta Fachini Criadoa, Paulo Ricardo Criadoa, Luis Felipe Ensinab, Beatrice Martinez Zugaib Abdallaa,
Corresponding author
dra.beatrice.abdalla@gmail.com

Autor para correspondência.
, Juarez Antônio Simões Quaresmac
a Faculdade de Medicina, Centro Universitário Saúde ABC, Santo André, SP, Brasil
b Divisão de Alergia, Imunologia Clínica e Reumatologia, Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brasil
c Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Pará, Belém, PA, Brasil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atualmente&#44; o tratamento da urtic&#225;ria cr&#244;nica &#40;UC&#41; segue um consenso internacional&#46; Quando a UC n&#227;o responde a anti&#8208;histam&#237;nicos por at&#233; quatro semanas&#44; orienta&#8208;se o uso do omalizumabe na dose de 300<span class="elsevierStyleHsp" style=""></span>mg subcut&#226;neo &#40;SC&#41; a cada quatro semanas&#44; por pelo menos seis meses&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2</span></a> H&#225; contraindica&#231;&#227;o formal de vacina&#231;&#227;o com v&#237;rus vivo atenuado em pacientes utilizando imunobiol&#243;gicos&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A partir de julho de 2017&#44; no Brasil&#44; houve uma epidemia de febre amarela &#40;FA&#41;&#59; a Organiza&#231;&#227;o Mundial da Sa&#250;de &#40;OMS&#41; recomendou a imuniza&#231;&#227;o com a vacina da febre amarela &#40;VFA&#41; na dose fracionada&#44; em car&#225;ter tempor&#225;rio&#44; como estrat&#233;gia de bloqueio da doenc&#807;a&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Como o omalizumabe age exclusivamente na IgE dos mast&#243;citos e bas&#243;filos&#44; e n&#227;o atua na imunidade celular&#44; nosso grupo recomendou a VFA em doentes com UC&#44; moradores de &#225;reas de risco para a FA&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">O presente trabalho teve como objetivo avaliar a ocorr&#234;ncia de rea&#231;&#245;es adversas &#224; VFA nos doentes com UC com e sem uso de omalizumabe e&#47;ou anti&#8208;histam&#237;nico&#46; Como objetivo secund&#225;rio&#44; foi avaliado o motivo da n&#227;o vacina&#231;&#227;o por alguns pacientes em uso de omalizumabe&#46; Conduziu&#8208;se um estudo transversal e observacional coletando os dados demogr&#225;ficos de 89 doentes com UC que estavam em seguimento no ambulat&#243;rio de urtic&#225;ria&#44; no per&#237;odo entre janeiro e abril de 2019&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Um question&#225;rio foi aplicado aos pacientes com UC e a pessoas sadias&#44; sobre eventos adversos &#224; imuniza&#231;&#227;o 30 dias ap&#243;s a vacina&#231;&#227;o&#44; e outro question&#225;rio para os doentes com UC que n&#227;o receberam a imuniza&#231;&#227;o&#44; a fim de se conhecer a motiva&#231;&#227;o que os levaram a n&#227;o receber a VFA&#46; Foram exclu&#237;dos os doentes que n&#227;o concordaram em participar do trabalho e assinar o termo de consentimento livre e esclarecido&#46; O estudo foi aprovado pelo Comit&#234; de &#201;tica em Pesquisa da institui&#231;&#227;o sob o n&#176; 2&#46;853&#46;158&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Os pacientes foram divididos nos seguintes grupos&#58; &#40;Grupo I&#41; 48 pacientes com UC em uso ou n&#227;o de omalizumabe&#47;anti&#8208;histam&#237;nico que receberam a VFA&#44; &#40;grupo III&#41; 41 pacientes com UC que n&#227;o receberam a VFA e &#40;grupo IIA&#41; 30 indiv&#237;duos normais &#40;sadios&#41; que fizeram uso da VFA &#40;grupo A&#41;&#46; No grupo I&#44; 48 indiv&#237;duos receberam a VFA &#8211; 30 deles estavam em uso de omalizumabe &#40;grupo B&#41;&#44; e 18 n&#227;o utilizavam omalizumabe &#40;grupo C&#44; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">As vari&#225;veis qualitativas foram apresentadas por frequ&#234;ncia absoluta e frequ&#234;ncia relativa&#44; e as vari&#225;veis quantitativas foram apresentadas por m&#233;dia&#44; desvio&#8208;padr&#227;o&#44; valores m&#225;ximo e m&#237;nimo&#44; mediante teste de normalidade dos dados de Shapiro&#8208;Wilk &#40;p<span class="elsevierStyleHsp" style=""></span>&#62; 0&#44;05&#41;&#46; Para comparar as vari&#225;veis qualitativas foi utilizado o teste exato de Fischer&#46; Para todas as an&#225;lises&#44; o n&#237;vel de signific&#226;ncia adotado foi &#945;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; O programa estat&#237;stico utilizado foi Stata vers&#227;o 1&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Foram aplicados question&#225;rios aos 89 pacientes com UC&#44; e aos 30 indiv&#237;duos sadios que receberam a VFA &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> est&#227;o os resultados dos dados demogr&#225;ficos&#44; subtipos de UC e tratamento dos pacientes inclu&#237;dos no estudo no per&#237;odo entre janeiro e abril de 2019&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Dos pacientes com UC&#44; 48 &#40;53&#44;93&#37;&#41; receberam a VFA concomitante ao tratamento e 41 &#40;46&#44;07&#37;&#41; n&#227;o a receberam&#46; Todos os 48 pacientes que tomaram a VFA responderam ao question&#225;rio sobre rea&#231;&#245;es adversas&#46; A maioria dos pacientes &#40;89&#44;58&#37;&#41; n&#227;o referiu nenhuma rea&#231;&#227;o adversa &#224; vacina&#44; em concomit&#226;ncia com o tratamento com o omalizamabe&#46; Foram relatados tr&#234;s &#40;6&#44;25&#37;&#41; casos com rea&#231;&#227;o local &#224; aplica&#231;&#227;o da VFA&#44; um &#40;2&#44;08&#37;&#41; de astenia e um &#40;2&#44;08&#37;&#41; com exacerba&#231;&#227;o da doen&#231;a apresentando angioedema&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ao grupo de pacientes com UC que respondeu n&#227;o ter tomado voluntariamente a VFA&#44; a maioria &#40;31&#44;71&#37;&#41; n&#227;o procurou a imuniza&#231;&#227;o em virtude de j&#225; ter sido imunizado anteriormente ao tratamento da UC&#59; 26&#44;83&#37; referiram &#8220;Foi informado que n&#227;o deveria tomar por causa do tratamento por outro profissional da sa&#250;de&#8221;&#59; 21&#44;95&#37; referiram &#8220;Decidiu n&#227;o tomar&#8221;&#59; 12&#44;20&#37; tiveram &#8220;Receio de tomar a vacina devido &#224; doen&#231;a&#8221;&#46; Os demais pacientes responderam ao question&#225;rio com as seguintes afirma&#231;&#245;es&#58; &#8220;N&#227;o teve tempo&#44; orientado a n&#227;o tomar a vacina por causa de cirurgia bari&#225;trica&#8221; e &#8220;Orientada a n&#227;o tomar a vacina devido &#224; gravidez&#8221; &#8211; cada resposta destas compreendeu 2&#44;44&#37; das respostas&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> encontram&#8208;se descritos os eventos adversos em 30 indiv&#237;duos sadios&#44; 30 doentes com UC tratados com omalizumabe e 18 doentes com UC sem uso de omalizumabe&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">A an&#225;lise estat&#237;stica&#44; utilizando o teste exato de Fischer&#44; n&#227;o demonstrou diferen&#231;as entre a presen&#231;a ou n&#227;o de rea&#231;&#245;es adversas entre os grupos A &#40;indiv&#237;duos sadios&#41;&#44; B &#40;doentes com UC tratados com omalizumabe&#41; e C &#40;doentes com UC sem uso de omalizumabe&#41;&#44; com p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;553&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">N&#227;o h&#225; relatos na literatura a respeito do uso de omalizumabe concomitante &#224; imuniza&#231;&#227;o contra a FA&#46; A imuniza&#231;&#227;o contra a FA nos pacientes com UC em uso de omalizumabe foi aconselhada&#44; pois as rea&#231;&#245;es mediadas pela IgE&#44; nos mast&#243;citos e bas&#243;filos&#44; n&#227;o s&#227;o cruciais ao combate de infec&#231;&#245;es virais&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Apenas tr&#234;s pacientes &#40;6&#44;25&#37;&#41; mencionaram rea&#231;&#227;o cut&#226;nea no local da aplica&#231;&#227;o da vacina&#46; A frequ&#234;ncia desse evento &#233; de 4&#37; na popula&#231;&#227;o que recebe a VFA&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Um indiv&#237;duo &#40;2&#44;08&#37;&#41; referiu astenia&#46; A ocorr&#234;ncia de manifesta&#231;&#227;o sist&#234;mica &#233; de 1&#37; a 6&#37; dos indiv&#237;duos&#46; Por fim&#44; um paciente &#40;2&#44;08&#37;&#41; referiu exacerba&#231;&#227;o do angioedema ao tomar a vacina&#44; o que pode estar ligado tanto a uma poss&#237;vel rea&#231;&#227;o &#224; VFA quanto &#224; flutua&#231;&#227;o na atividade do controle da urtic&#225;ria em tratamento&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Comparando&#8208;se os grupos doentes em uso do omalizumabe que tomaram a VFA e doentes com UC sem omalizumabe que tomaram a VFA&#44; n&#227;o houve diferen&#231;a estat&#237;stica&#46; No grupo controle das 30 pessoas sadias comparando&#8208;se aos 30 doentes com UC que faziam uso do omalizumabe e tomaram a VFA tamb&#233;m n&#227;o se observou diferen&#231;a estat&#237;stica em rela&#231;&#227;o aos efeitos adversos&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Nosso estudo mostrou que os doentes com UC em tratamento com anti&#8208;histam&#237;nicos e&#47;ou omalizumabe n&#227;o referiram eventos adversos ap&#243;s a imuniza&#231;&#227;o contra a FA&#44; quando comparados aos indiv&#237;duos sadios&#44; sem UC&#44; que receberam a imuniza&#231;&#227;o no mesmo per&#237;odo&#44; com a mesma vacina fornecida pelo Minist&#233;rio da Sa&#250;de do Brasil&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Suporte financeiro</span><p id="par0085" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Contribui&#231;&#227;o dos autores</span><p id="par0090" class="elsevierStylePara elsevierViewall">Laura Ramos de Almeida&#58; An&#225;lise estat&#237;stica&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Roberta Fachini Criado&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Paulo Ricardo Criado&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Luis Felipe Ensina&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Beatrice Martinez Zugaib Abdalla&#58; Aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; elabora&#231;&#227;o e reda&#231;&#227;o do manuscrito&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Juarez Ant&#244;nio Sim&#245;es Quaresma&#58; An&#225;lise estat&#237;stica&#59; aprova&#231;&#227;o da vers&#227;o final do manuscrito&#59; concep&#231;&#227;o e planejamento do estudo&#59; revis&#227;o cr&#237;tica da literatura&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflito de interesses</span><p id="par0120" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Manifesta&#231;&#245;es cl&#237;nicas</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>UC &#43; angiodema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>UC isolado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Angiodema isolado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Uso de omalizumabe</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tomou a vacina de febre amarela&#63;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dados demogr&#225;ficos&#44; tipo de urtic&#225;ria&#44; uso do omalizumabe e imuniza&#231;&#227;o contra a febre amarela entre os 89 doentes com urtic&#225;ria participantes do estudo</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Grupos de indiv&#237;duos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#245;es adversas atribu&#237;das &#224; vacina contra febre amarela</th><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col">Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nenhuma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rea&#231;&#227;o cut&#226;nea local&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Astenia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Exacerba&#231;&#227;o do angioedema&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Febre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grupo A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;83&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;10&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;6&#44;67&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grupo B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;90&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grupo C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;88&#44;89&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;11&#44;11&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;87&#44;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;7&#44;69&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;28&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;28&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;56&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab2658515.png"
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          "pt" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Compara&#231;&#227;o entre o relato de rea&#231;&#245;es adversas atribu&#237;das &#224; vacina&#231;&#227;o contra a febre amarela&#44; entre indiv&#237;duos sadios &#40;grupo A&#41;&#44; doentes com urtic&#225;ria cr&#244;nica tratados com omalizumabe &#40;grupo B&#41; doentes com urtic&#225;ria cr&#244;nica sem uso de omalizumabe &#40;grupo C&#41;</p>"
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Article information
ISSN: 26662752
Original language: Portuguese
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