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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Introdu&#231;&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">A dermatite at&#243;pica &#40;DA&#41; &#233; uma doen&#231;a inflamat&#243;ria da pele frequente e que afeta aproximadamente 20&#37; das crian&#231;as&#44; compromete a qualidade de vida do paciente e da fam&#237;lia&#46; Muta&#231;&#245;es no gene que codifica a prote&#237;na epid&#233;rmica filagrina demonstram ser um fator importante para o desenvolvimento dessa doen&#231;a&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> A filagrina tamb&#233;m est&#225; associada com a persist&#234;ncia e coexist&#234;ncia de outras doen&#231;as al&#233;rgicas&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A filagrina &#40;FILAGGRIN&#58; FILamentAGGRegatingproteIN&#41; &#233; uma prote&#237;na encontrada nos corne&#243;citos respons&#225;vel por agregar a queratina na forma&#231;&#227;o do estrato c&#243;rneo&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> &#201; produzida a partir de um precursor&#44; a pr&#243;&#8208;filagrina&#44; que se localiza na camada granulosa da epiderme nos gr&#226;nulos de querato hialina&#46; A pr&#243;&#8208;filagrina &#233; subsequentemente desfosforilada&#44; resulta na forma&#231;&#227;o de mon&#243;meros de filagrina que t&#234;m propriedades de agrega&#231;&#227;o de filamentos de queratina&#46; A degrada&#231;&#227;o da filagrina gera os fatores de hidrata&#231;&#227;o natural &#40;<span class="elsevierStyleItalic">Natural Mosturizing Factors</span> &#8722; NMFs&#41;&#44; que incluem amino&#225;cidos livres&#44; &#225;cido uroc&#226;nico &#40;UCA&#41; e &#225;cido pirrolid&#244;nico carbox&#237;lico &#40;PCA&#41;&#46; Os NMFs promovem capta&#231;&#227;o e aprisionamento da &#225;gua e manuten&#231;&#227;o do pH &#225;cido da pele&#44; essencial para o processo de hidrata&#231;&#227;o e manuten&#231;&#227;o da barreira cut&#226;nea&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">O gene que codifica a filagrina est&#225; localizado no cromossomo&#160;1q21&#44; em uma regi&#227;o denominada complexo de diferencia&#231;&#227;o epid&#233;rmica&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> De acordo com a literatura&#59; 27&#44;5&#37; dos brancos americanos&#59; 48&#37; dos europeus&#59; 31&#44;4&#37; dos chineses e 20&#37; dos japoneses portadores de dermatite at&#243;pica apresentam muta&#231;&#245;es no gene da filagrina&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Atualmente 47&#160;muta&#231;&#245;es com perda de fun&#231;&#227;o j&#225; foram identificadas no gene que codifica a filagrina em pacientes com DA&#46; Perfis distintos de muta&#231;&#245;es foram identificados em pacientes da Europa e da &#193;sia&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">6</span></a> Entre as muta&#231;&#245;es descritas&#44; as mais comumente encontradas nos brancos s&#227;o a R501X e a 2282del4 &#40;compreendem 50&#37; do total&#41;&#44; al&#233;m da R2447X e da S3247X&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> Na popula&#231;&#227;o japonesa&#44; as principais muta&#231;&#245;es foram a 3321delA e a S2554X&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> Essas muta&#231;&#245;es parecem variar de acordo com grupos &#233;tnicos&#44; por exemplo&#44; na popula&#231;&#227;o negra estudos demonstraram uma preval&#234;ncia bem menor que nos brancos&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> Gao et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> encontraram a R501X em 3&#44;2&#37; &#91;U1&#93; de 187&#160;pacientes negros com dermatite at&#243;pica e nenhuma associa&#231;&#227;o com 2282del4&#46; J&#225; Margolis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> avaliaram o gen&#243;tipo de 370&#160;negros com DA e encontraram muta&#231;&#245;es em apenas 1&#37; dos pacientes<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> &#40;R501X 3&#44;2&#37;&#59; 2282del4&#160;0&#44;5&#37;&#59; S3247X&#160;3&#37; e R2447X&#160;1&#44;4&#37;&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A filagrina&#160;2 &#233; uma prote&#237;na com fun&#231;&#227;o semelhante &#224; filagrina e tamb&#233;m codificada na regi&#227;o denominada complexo de diferencia&#231;&#227;o da epiderme&#46; De acordo com Makino et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> a express&#227;o da prote&#237;na filagrina&#160;2 est&#225; diminu&#237;da em portadores de DA&#46; H&#225; relato de uma associa&#231;&#227;o entre polimorfismos no gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;1689937411&#41; e DA persistente em pacientes negros portadores de dermatite at&#243;pica&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">N&#227;o h&#225; estudos sobre a preval&#234;ncia de filagrina e filagrina&#160;2 na popula&#231;&#227;o brasileira&#46; O objetivo deste estudo foi avaliar os polimorfismos no gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;16899374&#41; em crian&#231;as e adultos com dermatite at&#243;pica e verificar a associa&#231;&#227;o desses com a gravidade do quadro cl&#237;nico&#44; presen&#231;a de outras doen&#231;as al&#233;rgicas e fatores sociodemogr&#225;ficos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">M&#233;todos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Estudo transversal&#44; envolveu pacientes de ambos os sexos&#44; entre&#160;um&#160;e&#160;27&#160;anos&#44; com diagn&#243;stico de dermatite at&#243;pica&#44; de acordo com os crit&#233;rios da <span class="elsevierStyleItalic">United Kingdom Working Party</span> &#40;UK&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> recrutados nos ambulat&#243;rios de dermatite at&#243;pica&#46; Foram exclu&#237;dos aqueles com outras doen&#231;as cr&#244;nicas da pele &#40;psor&#237;ase&#44; entre outras&#41; ou doen&#231;as sist&#234;micas que afetam a pele&#44; como imunodefici&#234;ncias prim&#225;rias&#44; l&#250;pus eritematoso sist&#234;mico&#44; entre outras&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">De acordo com a ordem de chegada ao ambulat&#243;rio&#44; os pacientes responderam a um question&#225;rio com as seguintes vari&#225;veis&#58; sexo&#44; idade&#44; etnia&#44; in&#237;cio da DA&#44; hist&#243;ria familiar de doen&#231;as al&#233;rgicas e presen&#231;a de asma&#44; alergia alimentar e rinite&#46; Usou&#8208;se o question&#225;rio ISAAC&#44; validado para nossa linguagem&#44;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#44;15</span></a> para avaliar a presen&#231;a de asma e rinite&#46; Al&#233;m disso&#44; foi feita an&#225;lise da gravidade da DA pelo <span class="elsevierStyleItalic">Scoring Atopic Dermatitis</span> &#40;SCORAD&#41;&#46; Os n&#237;veis de gravidade da DA foram definidos como&#59; leve&#44; SCORAD at&#233;&#160;25&#160;pontos&#59; moderado&#44; entre&#160;25&#8211;50&#160;pontos&#59; e grave&#44; acima de&#160;50&#160;pontos&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Ap&#243;s a assinatura de termos de consentimento&#44; que relataram os principais objetivos&#44; riscos e benef&#237;cios da pesquisa&#44; por parte dos respons&#225;veis e de assentimento por parte dos pacientes adolescentes&#44; amostras de sangue venoso foram coletadas em tubos contendo EDTA&#46; A fim de aumentar a confiabilidade do estudo em rela&#231;&#227;o &#224; an&#225;lise das muta&#231;&#245;es&#44; foram analisadas amostras controle&#46; Devido &#224; dificuldade &#233;tica de criar um grupo controle pedi&#225;trico com coleta de sangue&#44; optou&#8208;se por amostras de um mesmo grupo populacional provenientes de um banco de medula &#243;ssea&#44; as quais foram pareadas por sexo e etnia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Para a determina&#231;&#227;o da varia&#231;&#227;o gen&#233;tica da filagrina&#160;2&#44; o DNA gen&#244;mico dos indiv&#237;duos participantes do estudo foi purificado com aux&#237;lio do kit QIAamp DNA Blood Mini kit &#40;Qiagen&#44; Valencia&#44; CA&#41;&#44; de acordo com as instru&#231;&#245;es do fabricante&#46; O princ&#237;pio desse kit baseia&#8208;se na extra&#231;&#227;o de DNA gen&#244;mico de c&#233;lulas sangu&#237;neas nucleadas e posterior liga&#231;&#227;o do DNA a uma matriz de fibra de vidro contida em uma coluna de MicroSpin&#46; Resumidamente&#44; ap&#243;s a digest&#227;o das membranas celulares pela proteinase&#160;K&#44; o material nucleico foi transferido para uma membrana de s&#237;lica&#44; onde sofreu v&#225;rias lavagens com solu&#231;&#245;es alco&#243;licas&#46; A elui&#231;&#227;o foi feita pela adi&#231;&#227;o de &#225;gua ultrapura&#46; O DNA gen&#244;mico foi quantificado atrav&#233;s da medida da absorb&#226;ncia na densidade &#243;ptica de 260&#160;nm &#40;OD260&#41; com o espectrofot&#244;metro NanoDrop Lite &#40;<span class="elsevierStyleItalic">ThermoScientific</span>&#41;&#46; A prepara&#231;&#227;o final foi armazenada a &#8208;20<span class="elsevierStyleHsp" style=""></span>&#176;C&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">A genotipagem do gene da filagrina&#160;2 &#40;rs&#160;16833974 e rs&#160;12568784&#41; foi feita atrav&#233;s de PCR em tempo real&#44; usou&#8208;se sonda TaqMan&#174; de uso comercial &#40;ABI assay&#59; <span class="elsevierStyleItalic">Applied Biosystems</span>&#41; marcada com os fluoroforos VIC e FAM para cada alelo&#44; sendo C&#95;34256909&#95;10 para rs16833974 e C&#95;11261511 para rs12568784&#46; Resumidamente&#44; a rea&#231;&#227;o foi feita em um volume final de 10&#160;uL&#44; com 40&#160;ng de DNA gen&#244;mico&#44; Taqman SNP GenotypingAssays 40X e TaqmanGenotyping Master Mix&#44; de acordo com as instru&#231;&#245;es do fabricante&#46; Inicialmente as amostras foram submetidas a uma etapa de leitura pr&#233;&#8208;PCR a 60<span class="elsevierStyleHsp" style=""></span>&#176;C por 30&#160;segundos&#44; seguida pela etapa de desnatura&#231;&#227;o a 95<span class="elsevierStyleHsp" style=""></span>&#176;C durante 10&#160;minutos&#46; Em seguida foram submetidas &#224; etapa de amplifica&#231;&#227;o&#44; que consistia em 40&#160;ciclos de 95<span class="elsevierStyleHsp" style=""></span>&#176;C por 15&#160;segundos e 60<span class="elsevierStyleHsp" style=""></span>&#176;C por 1&#160;minuto&#44; para anelamento do <span class="elsevierStyleItalic">primer</span> e extens&#227;o dos fragmentos&#46; Ap&#243;s a amplifica&#231;&#227;o dos fragmentos de DNA&#44; as amostras foram submetidas &#224; etapa final de leitura p&#243;s&#8208;PCR a 60<span class="elsevierStyleHsp" style=""></span>&#176;C durante 30 segundos&#46; A rea&#231;&#227;o da PCR foi feita com aux&#237;lio do termociclador ABI StepOnePlus Real&#8208;Time PCR System &#40;Applied Biosystems&#44; Foster City&#44; CA&#41;&#46; Os resultados da an&#225;lise de discrimina&#231;&#227;o al&#233;lica foram plotados em um gr&#225;fico de dispers&#227;o que contrastou a fluoresc&#234;ncia de cada sonda&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">An&#225;lise estat&#237;stica</span><p id="par0075" class="elsevierStylePara elsevierViewall">Usou&#8208;se uma amostra de 48&#160;pacientes com um grupo controle maior &#40;1&#44;7&#160;vez&#41; de 83&#160;pacientes&#44; para uma melhor an&#225;lise estat&#237;stica&#46; Fez&#8208;se uso das estat&#237;sticas de frequ&#234;ncia&#44; frequ&#234;ncia relativa e teste qui&#8208;quadrado linear para apresenta&#231;&#227;o das vari&#225;veis em tabelas descritivas&#44; com objetivo de compreender o perfil da amostra e tamb&#233;m do controle&#46; Com o intuito de verificar poss&#237;veis associa&#231;&#245;es usou&#8208;se o teste estat&#237;stico qui&#8208;quadrado&#44; ou o exato de Fisher&#44; para identificar evid&#234;ncias que comprovem signific&#226;ncia de determinadas vari&#225;veis em rela&#231;&#227;o &#224; muta&#231;&#227;o gen&#233;tica estudada e n&#237;vel de <span class="elsevierStyleItalic">Scoring Atopic Dermatitis</span> &#40;SCORAD&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Usou&#8208;se o n&#237;vel de signific&#226;ncia de&#160;0&#44;05&#59; p&#8208;valor&#160;&#60;&#160;0&#44;05 para avalia&#231;&#227;o das associa&#231;&#245;es entre a vari&#225;vel dependente &#40;muta&#231;&#245;es no gene da filagrina&#160;2&#41; e as demais vari&#225;veis de interesse do estudo&#46; Os programas Microsoft Excel 2010 e Software R&#44; vers&#227;o&#160;3&#46;3&#46;1 &#40;R Core Team 2015&#44; Viena&#44; &#193;ustria&#41;&#44; foram empregados para organiza&#231;&#227;o&#44; cria&#231;&#227;o de tabelas e an&#225;lise estat&#237;stica dos dados&#46; O estudo seguiu os princ&#237;pios da Declara&#231;&#227;o de Helsinki e foi aprovado pelo comit&#234; de &#233;tica sob parecer n&#176;&#160;36934514&#46;9&#46;0000&#46;5259&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Resultados</span><p id="par0090" class="elsevierStylePara elsevierViewall">De novembro&#160;de 2015 a fevereiro de&#160;2016 foram coletados os dados de&#160;48&#160;pacientes&#44; 54&#37; do sexo masculino&#46; O grupo controle foi constitu&#237;do por&#160;83&#160;amostras&#46; A preval&#234;ncia total do polimorfismo rs&#160;16833974 no grupo de pacientes &#233;&#160;16&#44;7&#37; &#40;14&#44;6&#37;&#160;heterozigoto e 2&#44;1&#37;&#160;homozigoto&#41; e no controle 15&#44;7&#37;&#160;&#40;heterozigotos&#41;&#46; J&#225; a preval&#234;ncia total do polimorfismo rs&#160;12568784 &#233;&#58;&#160;43&#44;7&#37; dos pacientes &#40;35&#44;4&#37;&#160;heterozigotos e 8&#44;3&#37;&#160;homozigotos&#41; e dos controles 46&#44;9&#37; &#40;37&#44;3&#37;&#160;heterozigoto e 9&#44;6&#37;&#160;homozigoto&#41;&#46; As principais caracter&#237;sticas da amostra e do grupo controle s&#227;o descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">A distribui&#231;&#227;o do polimorfismo gen&#233;tico de rs&#160;16833974 e rs&#160;12568784 de acordo com as vari&#225;veis sociodemogr&#225;ficas da amostra e do grupo controle &#233; demonstrada respectivamente na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">As principais vari&#225;veis estudadas foram&#58; sexo&#44; etnia&#44; SCORAD&#44; hist&#243;ria familiar de atopia e doen&#231;as al&#233;rgicas associadas&#46; Quanto ao polimorfismo rs&#160;16833974&#44; foram encontradas diferen&#231;as estat&#237;sticas quanto &#224; vari&#225;vel etnia&#44; quanto mais escura a cor da pele&#44; maior a chance de se ter o polimorfismo&#44; p&#8208;valor&#160;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#160;0&#44;031 &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Foram encontradas diferen&#231;as estatisticamente significantes&#44; p &#62; 0&#44;05&#44; de acordo com a <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Quanto ao polimorfismo rs12568784&#44; tamb&#233;m foram estudadas as seguintes vari&#225;veis&#58; sexo&#44; etnia&#44; SCORAD&#44; hist&#243;rico familiar de atopia e doen&#231;as al&#233;rgicas associadas &#40;alergia alimentar&#44; asma e rinite&#41; e n&#227;o foi encontrada signific&#226;ncia estat&#237;stica entre as vari&#225;veis&#44; exceto a vari&#225;vel parental&#46; O teste apresentou p&#8208;valor&#160;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#160;0&#44;032&#44; menor do que o n&#237;vel de signific&#226;ncia de&#160;0&#44;05&#160;&#40;5&#37;&#41;&#46; Visto isso&#44; &#233; poss&#237;vel afirmar a exist&#234;ncia de evid&#234;ncias estat&#237;sticas que comprovem alguma rela&#231;&#227;o de causa entre polimorfismo e atopia &#40;Pai&#41;&#46; De acordo com os dados da tabela pode&#8208;se perceber uma redu&#231;&#227;o no polimorfismo rs&#160;12568784 na presen&#231;a de Atopia &#40;Pai&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Foram feitos 46&#160;cruzamentos de interesses no total&#44; buscou&#8208;se verificar signific&#226;ncia estat&#237;stica entre polimorfismo e hist&#243;ria familiar&#44; sexo&#44; etnia&#44; gravidade da doen&#231;a&#44; atopia &#40;asma&#44; rinite&#44; alergia familiar&#41; e compara&#231;&#227;o com o controle quanto &#224; frequ&#234;ncia da muta&#231;&#227;o&#44; etnia e sexo&#46; Buscamos fazer avalia&#231;&#227;o separadamente dos polimorfismos heterozigotos e homozigotos&#44; por&#233;m nenhuma associa&#231;&#227;o foi encontrada&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discuss&#227;o</span><p id="par0125" class="elsevierStylePara elsevierViewall">A rela&#231;&#227;o entre polimorfismos do gene da filagrina&#160;2 e dermatite at&#243;pica foi recentemente relatada&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> De acordo com a literatura&#44; o polimorfismo da filagrina&#160;2 pode influenciar a gravidade do quadro&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> Neste estudo&#44; buscamos analisar alguns pontos dessa associa&#231;&#227;o de forma ampla&#44; atrav&#233;s da an&#225;lise explorat&#243;ria e correla&#231;&#227;o de dados cl&#237;nicos e demogr&#225;ficos&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">&#201; importante considerar que o grupo controle usado no estudo foi de conveni&#234;ncia&#44; com amostras de banco de medula &#243;ssea&#44; visto a dificuldade de organizar um grupo controle de crian&#231;as&#46; Foi feito pareamento de sexo e etnia entre os grupos&#46; Este &#233; o primeiro trabalho que usa controles para avaliar polimorfismos da filagrina&#160;2 e DA&#46; N&#227;o foram encontradas diferen&#231;as estat&#237;sticas entre a preval&#234;ncia dos polimorfismos no grupo de pacientes com DA e no grupo controle&#46; Al&#233;m disso&#44; tamb&#233;m n&#227;o houve diferen&#231;a quanto ao n&#237;vel de gravidade em pacientes portadores do polimorfismo&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Da mesma forma&#44; quando se analisaram as correla&#231;&#245;es entre a idade no in&#237;cio da DA e os polimorfismos&#44; n&#227;o houve diferen&#231;as estat&#237;sticas&#46; Assim como descrito por Margolis et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> tamb&#233;m n&#227;o foi encontrada associa&#231;&#227;o do polimorfismo com outros doen&#231;as at&#243;picas avaliadas &#40;asma&#44; rinite&#44; alergia alimentar&#41;&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">A hist&#243;ria familiar &#233; um importante fator de risco para o desenvolvimento da DA&#46; Aproximadamente&#160;70&#37; dos pacientes com DA apresentam hist&#243;ria familiar de doen&#231;as at&#243;picas&#46; A probabilidade de desenvolvimento da DA &#233; de cerca de duas a tr&#234;s vezes maior em crian&#231;as com um dos pais at&#243;picos e aumenta para tr&#234;s a cinco vezes se ambos os pais forem at&#243;picos&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">17</span></a> De um modo geral&#44; a hist&#243;ria materna de DA &#233; mais preditiva para o desenvolvimento de DA em rela&#231;&#227;o &#224; atopia paterna&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">18</span></a> Em nosso estudo&#44;&#160;85&#37; dos pacientes apresentaram hist&#243;ria familiar positiva para atopia&#44; corroboraram a literatura&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">De um modo geral&#44; n&#227;o foram observadas diferen&#231;as estat&#237;sticas entre hist&#243;ria familiar de atopia e polimorfismos de filagrina&#160;2&#44; exceto para aumento da frequ&#234;ncia da muta&#231;&#227;o do polimorfismo rs&#160;12568784 na presen&#231;a de atopia paterna&#46; Esse dado pode referir&#8208;se apenas a um achado estat&#237;stico&#44; em fun&#231;&#227;o do reduzido n&#250;mero amostral e possivelmente sem plausibilidade biol&#243;gica&#46; Mais estudos s&#227;o necess&#225;rios para elucidar esse achado&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">De acordo com Margolis et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> os polimorfismos do gene da filagrina&#160;2&#44; rs&#160;12568784 e rs&#160;16833974&#44; est&#227;o associadas com a persist&#234;ncia da DA em negros e est&#227;o ausentes&#44; ou s&#227;o raramente encontrados&#44; em indiv&#237;duos de origem europeia&#46; Na popula&#231;&#227;o do estudo&#44; houve signific&#226;ncia estat&#237;stica entre o polimorfismo rs&#160;16833974 e os pacientes com DA autodeclarados negros&#44; o que corroborou a literatura&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">A popula&#231;&#227;o brasileira tem um alto grau de miscigena&#231;&#227;o e segue diferentes padr&#245;es &#233;tnicos quando comparada a grupos populacionais de outros pa&#237;ses e continentes&#44; como China&#44; Estados Unidos&#44; Jap&#227;o e Europa&#44; onde j&#225; existem estudos com preval&#234;ncia da filagrina&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a> Portanto&#44; &#233; dif&#237;cil estabelecer uma classifica&#231;&#227;o por etnias em nosso pa&#237;s&#46; O uso exclusivo de informa&#231;&#245;es da etnia autodeclarada n&#227;o &#233; o melhor m&#233;todo para&#160;classi&#64257;ca&#231;&#227;o &#233;tnica<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> e &#233; uma limita&#231;&#227;o do estudo&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Os genomas da maioria dos brasileiros s&#227;o miscigenados e os marcadores gen&#233;ticos s&#227;o capazes de fornecer novos e valiosos <span class="elsevierStyleItalic">insights</span> sobre a estrutura atual da popula&#231;&#227;o brasileira&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Perspectivas futuras de an&#225;lises de ancestralidade das amostras sangu&#237;neas de nosso estudo poder&#227;o permitir um melhor esclarecimento acerca da associa&#231;&#227;o entre a filagrina&#160;2 e DA&#44; visto que a preval&#234;ncia das muta&#231;&#245;es do gene da filagrina apresenta diferen&#231;as &#233;tnicas tanto na popula&#231;&#227;o geral quanto em indiv&#237;duos portadores de DA&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">O pequeno tamanho amostral pode ter limitado a signific&#226;ncia de nossos resultados e talvez uma maior amostra e&#47;ou o estudo de ancestralidade poder&#225; contribuir para o esclarecimento entre indiv&#237;duos com DA e os polimorfismo da filagrina&#160;2&#46; A feitura do estudo prote&#244;mico da filagrina&#160;2&#44; j&#225; que diferen&#231;as estruturais podem se dever a controles p&#243;s&#8208;transcricionais&#44; tamb&#233;m contribuiria para uma melhor avalia&#231;&#227;o da filagrina&#160;2&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">At&#233; o momento&#44; n&#227;o h&#225; estudos de polimorfismos do gene da filagrina&#160;2 e DA na Am&#233;rica Latina&#44; o que refor&#231;ando a relev&#226;ncia de nosso estudo e o ineditismo dessa iniciativa no Brasil&#46; Al&#233;m disso&#44; este &#233; o primeiro estudo em n&#237;vel mundial que usa um grupo controle para avaliar altera&#231;&#245;es no gene da filagrina&#160;2&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclus&#227;o</span><p id="par0185" class="elsevierStylePara elsevierViewall">Muito pouco se sabe sobre o perfil de polimorfismos de filagrinas&#160;2 associados &#224; DA na altamente miscigenada popula&#231;&#227;o brasileira&#46; Os resultados deste trabalho podem ser um consider&#225;vel incentivo &#224;s pesquisas sobre polimorfismos e DA no pa&#237;s&#44; colaborar para uma melhor compreens&#227;o&#44; n&#227;o apenas de formas de tratamento da doen&#231;a&#44; mas tamb&#233;m do perfil gen&#233;tico da popula&#231;&#227;o&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Quanto ao polimorfismo rs16833974&#44; foram encontradas diferen&#231;as estatisticamente significantes em rela&#231;&#227;o &#224; vari&#225;vel etnia&#46; Quanto mais escura a cor da pele&#44; maior a chance de ocorrer o polimorfismo&#44; valor de p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Suporte financeiro</span><p id="par0200" class="elsevierStylePara elsevierViewall">Fundo de Apoio &#224; Dermatologia &#40;Funaderm&#41;&#44; da Sociedade Brasileira de Dermatologia&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Contribui&#231;&#227;o dos autores</span><p id="par0210" class="elsevierStylePara elsevierViewall">Amanda Hertz&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Luna Azulay&#8208;Abulafia&#58; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Adriana Paulino do Nascimento&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Cintya Yumi Ohara&#58; Concep&#231;&#227;o e planejamento do estudo&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Fabio Chigres Kuschnir&#58; Revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Lu&#237;s Cristov&#227;o Porto&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflitos de interesse</span><p id="par0245" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Polimorfismos do gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;16899374&#41; est&#227;o associados com dermatite at&#243;pica persistente em pacientes negros&#46; A filagrina&#160;2 &#233; uma prote&#237;na com fun&#231;&#227;o semelhante &#224; filagrina e tamb&#233;m codificada no complexo de diferencia&#231;&#227;o da epiderme no cromossomo 1q21&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar os polimorfismos no gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;16899374&#41; em crian&#231;as e adultos com dermatite at&#243;pica e verificar a associa&#231;&#227;o desses com a gravidade do quadro cl&#237;nico&#44; presen&#231;a de outras doen&#231;as al&#233;rgicas e fatores sociodemogr&#225;ficos&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">O estudo foi feito com pacientes do ambulat&#243;rio de dermatite at&#243;pica e grupo controle&#46; Foram usados question&#225;rios para avaliar etnia&#44; sexo&#44; faixa et&#225;ria&#44; hist&#243;rico familiar&#44; <span class="elsevierStyleItalic">Scoring</span><span class="elsevierStyleItalic">Atopic Dermatitis</span> &#40;SCORAD&#41;&#44; entre outros par&#226;metros&#46; A genotipagem do gene da filagrina&#160;2 foi feita atrav&#233;s de rea&#231;&#227;o em cadeia da polimerase em tempo real&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram avaliados&#160;48&#160;pacientes e 83&#160;controles&#46; N&#227;o foi encontrada uma correla&#231;&#227;o entre as vari&#225;veis estudadas dos pacientes com dermatite at&#243;pica e os polimorfismos&#46; Tamb&#233;m n&#227;o houve diferen&#231;a significativa entre a preval&#234;ncia dos polimorfismos nos pacientes e no grupo controle p&#160;&#62;&#160;0&#44;05&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O uso exclusivo de informa&#231;&#245;es da etnia autodeclarada e o n&#250;mero da amostra&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Os resultados deste trabalho podem ser um incentivo para o estudo de polimorfismos na dermatite at&#243;pica&#44; considerando&#8208;se a caracter&#237;stica multi&#233;tnica da popula&#231;&#227;o brasileira&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclus&#227;o</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Este &#233; um trabalho in&#233;dito no Brasil e o primeiro estudo no mundo a ter um grupo controle para avaliar altera&#231;&#245;es no gene da filagrina&#160;2&#46;</p></span>"
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pardos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pretos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infanto &#40;0&#8211;2 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#8211;30 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crian&#231;as &#40;3&#8211;9 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#8211;45 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adolescentes &#40;10&#8211;19 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 45 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adultos &#40;20&#160;anos ou mais&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
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            "detalle" => "Tabela "
            "rol" => "short"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Vari&#225;veis sociodemogr&#225;ficas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="10" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Polimorfismo rs16833974</th></tr><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="5" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="5" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controle</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Presente</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ausente</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Presente</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ausente</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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            1 => array:2 [
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                  \t\t\t\t" scope="col">Vari&#225;veis sociodemogr&#225;ficas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Vari&#225;veis estudadas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Polimorfismo rs 16833974</th><th class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="8" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Alergia alimentar</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t" scope="col">Vari&#225;veis estudadas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Polimorfismo rs12568784</th><th class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Alergia alimentar</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&#37;&nbsp;\t\t\t\t\t\t\n
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Investigação
Análise dos polimorfismos no gene da filagrina 2 em pacientes com dermatite atópica
Amanda Hertza,
Corresponding author
hertzamanda@gmail.com

Autor para correspondência.
, Luna Azulay‐Abulafiab, Adriana Paulino do Nascimentoc, Cintya Yumi Oharad, Fabio Chigres Kuschnire,f, Luís Cristovão Portoc
a Ambulatório de Dermatologia Pediátrica, Instituto de Dermatologia Prof. Rubem David Azulay, Rio de Janeiro, RJ, Brasil
b Departamento de Dermatologia, Instituto de Dermatologia Prof. Rubem David Azulay, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
c Laboratório de Histocompatibilidade e Criopreservação, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
d Departamento de Alergia e Imunopatologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
e Departamento de Pediatria, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
f Departamento de Alergia, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Introdu&#231;&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">A dermatite at&#243;pica &#40;DA&#41; &#233; uma doen&#231;a inflamat&#243;ria da pele frequente e que afeta aproximadamente 20&#37; das crian&#231;as&#44; compromete a qualidade de vida do paciente e da fam&#237;lia&#46; Muta&#231;&#245;es no gene que codifica a prote&#237;na epid&#233;rmica filagrina demonstram ser um fator importante para o desenvolvimento dessa doen&#231;a&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> A filagrina tamb&#233;m est&#225; associada com a persist&#234;ncia e coexist&#234;ncia de outras doen&#231;as al&#233;rgicas&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A filagrina &#40;FILAGGRIN&#58; FILamentAGGRegatingproteIN&#41; &#233; uma prote&#237;na encontrada nos corne&#243;citos respons&#225;vel por agregar a queratina na forma&#231;&#227;o do estrato c&#243;rneo&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> &#201; produzida a partir de um precursor&#44; a pr&#243;&#8208;filagrina&#44; que se localiza na camada granulosa da epiderme nos gr&#226;nulos de querato hialina&#46; A pr&#243;&#8208;filagrina &#233; subsequentemente desfosforilada&#44; resulta na forma&#231;&#227;o de mon&#243;meros de filagrina que t&#234;m propriedades de agrega&#231;&#227;o de filamentos de queratina&#46; A degrada&#231;&#227;o da filagrina gera os fatores de hidrata&#231;&#227;o natural &#40;<span class="elsevierStyleItalic">Natural Mosturizing Factors</span> &#8722; NMFs&#41;&#44; que incluem amino&#225;cidos livres&#44; &#225;cido uroc&#226;nico &#40;UCA&#41; e &#225;cido pirrolid&#244;nico carbox&#237;lico &#40;PCA&#41;&#46; Os NMFs promovem capta&#231;&#227;o e aprisionamento da &#225;gua e manuten&#231;&#227;o do pH &#225;cido da pele&#44; essencial para o processo de hidrata&#231;&#227;o e manuten&#231;&#227;o da barreira cut&#226;nea&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">O gene que codifica a filagrina est&#225; localizado no cromossomo&#160;1q21&#44; em uma regi&#227;o denominada complexo de diferencia&#231;&#227;o epid&#233;rmica&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> De acordo com a literatura&#59; 27&#44;5&#37; dos brancos americanos&#59; 48&#37; dos europeus&#59; 31&#44;4&#37; dos chineses e 20&#37; dos japoneses portadores de dermatite at&#243;pica apresentam muta&#231;&#245;es no gene da filagrina&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Atualmente 47&#160;muta&#231;&#245;es com perda de fun&#231;&#227;o j&#225; foram identificadas no gene que codifica a filagrina em pacientes com DA&#46; Perfis distintos de muta&#231;&#245;es foram identificados em pacientes da Europa e da &#193;sia&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">6</span></a> Entre as muta&#231;&#245;es descritas&#44; as mais comumente encontradas nos brancos s&#227;o a R501X e a 2282del4 &#40;compreendem 50&#37; do total&#41;&#44; al&#233;m da R2447X e da S3247X&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> Na popula&#231;&#227;o japonesa&#44; as principais muta&#231;&#245;es foram a 3321delA e a S2554X&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> Essas muta&#231;&#245;es parecem variar de acordo com grupos &#233;tnicos&#44; por exemplo&#44; na popula&#231;&#227;o negra estudos demonstraram uma preval&#234;ncia bem menor que nos brancos&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> Gao et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> encontraram a R501X em 3&#44;2&#37; &#91;U1&#93; de 187&#160;pacientes negros com dermatite at&#243;pica e nenhuma associa&#231;&#227;o com 2282del4&#46; J&#225; Margolis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> avaliaram o gen&#243;tipo de 370&#160;negros com DA e encontraram muta&#231;&#245;es em apenas 1&#37; dos pacientes<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> &#40;R501X 3&#44;2&#37;&#59; 2282del4&#160;0&#44;5&#37;&#59; S3247X&#160;3&#37; e R2447X&#160;1&#44;4&#37;&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A filagrina&#160;2 &#233; uma prote&#237;na com fun&#231;&#227;o semelhante &#224; filagrina e tamb&#233;m codificada na regi&#227;o denominada complexo de diferencia&#231;&#227;o da epiderme&#46; De acordo com Makino et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> a express&#227;o da prote&#237;na filagrina&#160;2 est&#225; diminu&#237;da em portadores de DA&#46; H&#225; relato de uma associa&#231;&#227;o entre polimorfismos no gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;1689937411&#41; e DA persistente em pacientes negros portadores de dermatite at&#243;pica&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">N&#227;o h&#225; estudos sobre a preval&#234;ncia de filagrina e filagrina&#160;2 na popula&#231;&#227;o brasileira&#46; O objetivo deste estudo foi avaliar os polimorfismos no gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;16899374&#41; em crian&#231;as e adultos com dermatite at&#243;pica e verificar a associa&#231;&#227;o desses com a gravidade do quadro cl&#237;nico&#44; presen&#231;a de outras doen&#231;as al&#233;rgicas e fatores sociodemogr&#225;ficos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">M&#233;todos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Estudo transversal&#44; envolveu pacientes de ambos os sexos&#44; entre&#160;um&#160;e&#160;27&#160;anos&#44; com diagn&#243;stico de dermatite at&#243;pica&#44; de acordo com os crit&#233;rios da <span class="elsevierStyleItalic">United Kingdom Working Party</span> &#40;UK&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> recrutados nos ambulat&#243;rios de dermatite at&#243;pica&#46; Foram exclu&#237;dos aqueles com outras doen&#231;as cr&#244;nicas da pele &#40;psor&#237;ase&#44; entre outras&#41; ou doen&#231;as sist&#234;micas que afetam a pele&#44; como imunodefici&#234;ncias prim&#225;rias&#44; l&#250;pus eritematoso sist&#234;mico&#44; entre outras&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">De acordo com a ordem de chegada ao ambulat&#243;rio&#44; os pacientes responderam a um question&#225;rio com as seguintes vari&#225;veis&#58; sexo&#44; idade&#44; etnia&#44; in&#237;cio da DA&#44; hist&#243;ria familiar de doen&#231;as al&#233;rgicas e presen&#231;a de asma&#44; alergia alimentar e rinite&#46; Usou&#8208;se o question&#225;rio ISAAC&#44; validado para nossa linguagem&#44;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#44;15</span></a> para avaliar a presen&#231;a de asma e rinite&#46; Al&#233;m disso&#44; foi feita an&#225;lise da gravidade da DA pelo <span class="elsevierStyleItalic">Scoring Atopic Dermatitis</span> &#40;SCORAD&#41;&#46; Os n&#237;veis de gravidade da DA foram definidos como&#59; leve&#44; SCORAD at&#233;&#160;25&#160;pontos&#59; moderado&#44; entre&#160;25&#8211;50&#160;pontos&#59; e grave&#44; acima de&#160;50&#160;pontos&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Ap&#243;s a assinatura de termos de consentimento&#44; que relataram os principais objetivos&#44; riscos e benef&#237;cios da pesquisa&#44; por parte dos respons&#225;veis e de assentimento por parte dos pacientes adolescentes&#44; amostras de sangue venoso foram coletadas em tubos contendo EDTA&#46; A fim de aumentar a confiabilidade do estudo em rela&#231;&#227;o &#224; an&#225;lise das muta&#231;&#245;es&#44; foram analisadas amostras controle&#46; Devido &#224; dificuldade &#233;tica de criar um grupo controle pedi&#225;trico com coleta de sangue&#44; optou&#8208;se por amostras de um mesmo grupo populacional provenientes de um banco de medula &#243;ssea&#44; as quais foram pareadas por sexo e etnia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Para a determina&#231;&#227;o da varia&#231;&#227;o gen&#233;tica da filagrina&#160;2&#44; o DNA gen&#244;mico dos indiv&#237;duos participantes do estudo foi purificado com aux&#237;lio do kit QIAamp DNA Blood Mini kit &#40;Qiagen&#44; Valencia&#44; CA&#41;&#44; de acordo com as instru&#231;&#245;es do fabricante&#46; O princ&#237;pio desse kit baseia&#8208;se na extra&#231;&#227;o de DNA gen&#244;mico de c&#233;lulas sangu&#237;neas nucleadas e posterior liga&#231;&#227;o do DNA a uma matriz de fibra de vidro contida em uma coluna de MicroSpin&#46; Resumidamente&#44; ap&#243;s a digest&#227;o das membranas celulares pela proteinase&#160;K&#44; o material nucleico foi transferido para uma membrana de s&#237;lica&#44; onde sofreu v&#225;rias lavagens com solu&#231;&#245;es alco&#243;licas&#46; A elui&#231;&#227;o foi feita pela adi&#231;&#227;o de &#225;gua ultrapura&#46; O DNA gen&#244;mico foi quantificado atrav&#233;s da medida da absorb&#226;ncia na densidade &#243;ptica de 260&#160;nm &#40;OD260&#41; com o espectrofot&#244;metro NanoDrop Lite &#40;<span class="elsevierStyleItalic">ThermoScientific</span>&#41;&#46; A prepara&#231;&#227;o final foi armazenada a &#8208;20<span class="elsevierStyleHsp" style=""></span>&#176;C&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">A genotipagem do gene da filagrina&#160;2 &#40;rs&#160;16833974 e rs&#160;12568784&#41; foi feita atrav&#233;s de PCR em tempo real&#44; usou&#8208;se sonda TaqMan&#174; de uso comercial &#40;ABI assay&#59; <span class="elsevierStyleItalic">Applied Biosystems</span>&#41; marcada com os fluoroforos VIC e FAM para cada alelo&#44; sendo C&#95;34256909&#95;10 para rs16833974 e C&#95;11261511 para rs12568784&#46; Resumidamente&#44; a rea&#231;&#227;o foi feita em um volume final de 10&#160;uL&#44; com 40&#160;ng de DNA gen&#244;mico&#44; Taqman SNP GenotypingAssays 40X e TaqmanGenotyping Master Mix&#44; de acordo com as instru&#231;&#245;es do fabricante&#46; Inicialmente as amostras foram submetidas a uma etapa de leitura pr&#233;&#8208;PCR a 60<span class="elsevierStyleHsp" style=""></span>&#176;C por 30&#160;segundos&#44; seguida pela etapa de desnatura&#231;&#227;o a 95<span class="elsevierStyleHsp" style=""></span>&#176;C durante 10&#160;minutos&#46; Em seguida foram submetidas &#224; etapa de amplifica&#231;&#227;o&#44; que consistia em 40&#160;ciclos de 95<span class="elsevierStyleHsp" style=""></span>&#176;C por 15&#160;segundos e 60<span class="elsevierStyleHsp" style=""></span>&#176;C por 1&#160;minuto&#44; para anelamento do <span class="elsevierStyleItalic">primer</span> e extens&#227;o dos fragmentos&#46; Ap&#243;s a amplifica&#231;&#227;o dos fragmentos de DNA&#44; as amostras foram submetidas &#224; etapa final de leitura p&#243;s&#8208;PCR a 60<span class="elsevierStyleHsp" style=""></span>&#176;C durante 30 segundos&#46; A rea&#231;&#227;o da PCR foi feita com aux&#237;lio do termociclador ABI StepOnePlus Real&#8208;Time PCR System &#40;Applied Biosystems&#44; Foster City&#44; CA&#41;&#46; Os resultados da an&#225;lise de discrimina&#231;&#227;o al&#233;lica foram plotados em um gr&#225;fico de dispers&#227;o que contrastou a fluoresc&#234;ncia de cada sonda&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">An&#225;lise estat&#237;stica</span><p id="par0075" class="elsevierStylePara elsevierViewall">Usou&#8208;se uma amostra de 48&#160;pacientes com um grupo controle maior &#40;1&#44;7&#160;vez&#41; de 83&#160;pacientes&#44; para uma melhor an&#225;lise estat&#237;stica&#46; Fez&#8208;se uso das estat&#237;sticas de frequ&#234;ncia&#44; frequ&#234;ncia relativa e teste qui&#8208;quadrado linear para apresenta&#231;&#227;o das vari&#225;veis em tabelas descritivas&#44; com objetivo de compreender o perfil da amostra e tamb&#233;m do controle&#46; Com o intuito de verificar poss&#237;veis associa&#231;&#245;es usou&#8208;se o teste estat&#237;stico qui&#8208;quadrado&#44; ou o exato de Fisher&#44; para identificar evid&#234;ncias que comprovem signific&#226;ncia de determinadas vari&#225;veis em rela&#231;&#227;o &#224; muta&#231;&#227;o gen&#233;tica estudada e n&#237;vel de <span class="elsevierStyleItalic">Scoring Atopic Dermatitis</span> &#40;SCORAD&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Usou&#8208;se o n&#237;vel de signific&#226;ncia de&#160;0&#44;05&#59; p&#8208;valor&#160;&#60;&#160;0&#44;05 para avalia&#231;&#227;o das associa&#231;&#245;es entre a vari&#225;vel dependente &#40;muta&#231;&#245;es no gene da filagrina&#160;2&#41; e as demais vari&#225;veis de interesse do estudo&#46; Os programas Microsoft Excel 2010 e Software R&#44; vers&#227;o&#160;3&#46;3&#46;1 &#40;R Core Team 2015&#44; Viena&#44; &#193;ustria&#41;&#44; foram empregados para organiza&#231;&#227;o&#44; cria&#231;&#227;o de tabelas e an&#225;lise estat&#237;stica dos dados&#46; O estudo seguiu os princ&#237;pios da Declara&#231;&#227;o de Helsinki e foi aprovado pelo comit&#234; de &#233;tica sob parecer n&#176;&#160;36934514&#46;9&#46;0000&#46;5259&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Resultados</span><p id="par0090" class="elsevierStylePara elsevierViewall">De novembro&#160;de 2015 a fevereiro de&#160;2016 foram coletados os dados de&#160;48&#160;pacientes&#44; 54&#37; do sexo masculino&#46; O grupo controle foi constitu&#237;do por&#160;83&#160;amostras&#46; A preval&#234;ncia total do polimorfismo rs&#160;16833974 no grupo de pacientes &#233;&#160;16&#44;7&#37; &#40;14&#44;6&#37;&#160;heterozigoto e 2&#44;1&#37;&#160;homozigoto&#41; e no controle 15&#44;7&#37;&#160;&#40;heterozigotos&#41;&#46; J&#225; a preval&#234;ncia total do polimorfismo rs&#160;12568784 &#233;&#58;&#160;43&#44;7&#37; dos pacientes &#40;35&#44;4&#37;&#160;heterozigotos e 8&#44;3&#37;&#160;homozigotos&#41; e dos controles 46&#44;9&#37; &#40;37&#44;3&#37;&#160;heterozigoto e 9&#44;6&#37;&#160;homozigoto&#41;&#46; As principais caracter&#237;sticas da amostra e do grupo controle s&#227;o descritas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">A distribui&#231;&#227;o do polimorfismo gen&#233;tico de rs&#160;16833974 e rs&#160;12568784 de acordo com as vari&#225;veis sociodemogr&#225;ficas da amostra e do grupo controle &#233; demonstrada respectivamente na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">As principais vari&#225;veis estudadas foram&#58; sexo&#44; etnia&#44; SCORAD&#44; hist&#243;ria familiar de atopia e doen&#231;as al&#233;rgicas associadas&#46; Quanto ao polimorfismo rs&#160;16833974&#44; foram encontradas diferen&#231;as estat&#237;sticas quanto &#224; vari&#225;vel etnia&#44; quanto mais escura a cor da pele&#44; maior a chance de se ter o polimorfismo&#44; p&#8208;valor&#160;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#160;0&#44;031 &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Foram encontradas diferen&#231;as estatisticamente significantes&#44; p &#62; 0&#44;05&#44; de acordo com a <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Quanto ao polimorfismo rs12568784&#44; tamb&#233;m foram estudadas as seguintes vari&#225;veis&#58; sexo&#44; etnia&#44; SCORAD&#44; hist&#243;rico familiar de atopia e doen&#231;as al&#233;rgicas associadas &#40;alergia alimentar&#44; asma e rinite&#41; e n&#227;o foi encontrada signific&#226;ncia estat&#237;stica entre as vari&#225;veis&#44; exceto a vari&#225;vel parental&#46; O teste apresentou p&#8208;valor&#160;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#160;0&#44;032&#44; menor do que o n&#237;vel de signific&#226;ncia de&#160;0&#44;05&#160;&#40;5&#37;&#41;&#46; Visto isso&#44; &#233; poss&#237;vel afirmar a exist&#234;ncia de evid&#234;ncias estat&#237;sticas que comprovem alguma rela&#231;&#227;o de causa entre polimorfismo e atopia &#40;Pai&#41;&#46; De acordo com os dados da tabela pode&#8208;se perceber uma redu&#231;&#227;o no polimorfismo rs&#160;12568784 na presen&#231;a de Atopia &#40;Pai&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Foram feitos 46&#160;cruzamentos de interesses no total&#44; buscou&#8208;se verificar signific&#226;ncia estat&#237;stica entre polimorfismo e hist&#243;ria familiar&#44; sexo&#44; etnia&#44; gravidade da doen&#231;a&#44; atopia &#40;asma&#44; rinite&#44; alergia familiar&#41; e compara&#231;&#227;o com o controle quanto &#224; frequ&#234;ncia da muta&#231;&#227;o&#44; etnia e sexo&#46; Buscamos fazer avalia&#231;&#227;o separadamente dos polimorfismos heterozigotos e homozigotos&#44; por&#233;m nenhuma associa&#231;&#227;o foi encontrada&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discuss&#227;o</span><p id="par0125" class="elsevierStylePara elsevierViewall">A rela&#231;&#227;o entre polimorfismos do gene da filagrina&#160;2 e dermatite at&#243;pica foi recentemente relatada&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> De acordo com a literatura&#44; o polimorfismo da filagrina&#160;2 pode influenciar a gravidade do quadro&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> Neste estudo&#44; buscamos analisar alguns pontos dessa associa&#231;&#227;o de forma ampla&#44; atrav&#233;s da an&#225;lise explorat&#243;ria e correla&#231;&#227;o de dados cl&#237;nicos e demogr&#225;ficos&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">&#201; importante considerar que o grupo controle usado no estudo foi de conveni&#234;ncia&#44; com amostras de banco de medula &#243;ssea&#44; visto a dificuldade de organizar um grupo controle de crian&#231;as&#46; Foi feito pareamento de sexo e etnia entre os grupos&#46; Este &#233; o primeiro trabalho que usa controles para avaliar polimorfismos da filagrina&#160;2 e DA&#46; N&#227;o foram encontradas diferen&#231;as estat&#237;sticas entre a preval&#234;ncia dos polimorfismos no grupo de pacientes com DA e no grupo controle&#46; Al&#233;m disso&#44; tamb&#233;m n&#227;o houve diferen&#231;a quanto ao n&#237;vel de gravidade em pacientes portadores do polimorfismo&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Da mesma forma&#44; quando se analisaram as correla&#231;&#245;es entre a idade no in&#237;cio da DA e os polimorfismos&#44; n&#227;o houve diferen&#231;as estat&#237;sticas&#46; Assim como descrito por Margolis et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> tamb&#233;m n&#227;o foi encontrada associa&#231;&#227;o do polimorfismo com outros doen&#231;as at&#243;picas avaliadas &#40;asma&#44; rinite&#44; alergia alimentar&#41;&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">A hist&#243;ria familiar &#233; um importante fator de risco para o desenvolvimento da DA&#46; Aproximadamente&#160;70&#37; dos pacientes com DA apresentam hist&#243;ria familiar de doen&#231;as at&#243;picas&#46; A probabilidade de desenvolvimento da DA &#233; de cerca de duas a tr&#234;s vezes maior em crian&#231;as com um dos pais at&#243;picos e aumenta para tr&#234;s a cinco vezes se ambos os pais forem at&#243;picos&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">17</span></a> De um modo geral&#44; a hist&#243;ria materna de DA &#233; mais preditiva para o desenvolvimento de DA em rela&#231;&#227;o &#224; atopia paterna&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">18</span></a> Em nosso estudo&#44;&#160;85&#37; dos pacientes apresentaram hist&#243;ria familiar positiva para atopia&#44; corroboraram a literatura&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">De um modo geral&#44; n&#227;o foram observadas diferen&#231;as estat&#237;sticas entre hist&#243;ria familiar de atopia e polimorfismos de filagrina&#160;2&#44; exceto para aumento da frequ&#234;ncia da muta&#231;&#227;o do polimorfismo rs&#160;12568784 na presen&#231;a de atopia paterna&#46; Esse dado pode referir&#8208;se apenas a um achado estat&#237;stico&#44; em fun&#231;&#227;o do reduzido n&#250;mero amostral e possivelmente sem plausibilidade biol&#243;gica&#46; Mais estudos s&#227;o necess&#225;rios para elucidar esse achado&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">De acordo com Margolis et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> os polimorfismos do gene da filagrina&#160;2&#44; rs&#160;12568784 e rs&#160;16833974&#44; est&#227;o associadas com a persist&#234;ncia da DA em negros e est&#227;o ausentes&#44; ou s&#227;o raramente encontrados&#44; em indiv&#237;duos de origem europeia&#46; Na popula&#231;&#227;o do estudo&#44; houve signific&#226;ncia estat&#237;stica entre o polimorfismo rs&#160;16833974 e os pacientes com DA autodeclarados negros&#44; o que corroborou a literatura&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">A popula&#231;&#227;o brasileira tem um alto grau de miscigena&#231;&#227;o e segue diferentes padr&#245;es &#233;tnicos quando comparada a grupos populacionais de outros pa&#237;ses e continentes&#44; como China&#44; Estados Unidos&#44; Jap&#227;o e Europa&#44; onde j&#225; existem estudos com preval&#234;ncia da filagrina&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a> Portanto&#44; &#233; dif&#237;cil estabelecer uma classifica&#231;&#227;o por etnias em nosso pa&#237;s&#46; O uso exclusivo de informa&#231;&#245;es da etnia autodeclarada n&#227;o &#233; o melhor m&#233;todo para&#160;classi&#64257;ca&#231;&#227;o &#233;tnica<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> e &#233; uma limita&#231;&#227;o do estudo&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Os genomas da maioria dos brasileiros s&#227;o miscigenados e os marcadores gen&#233;ticos s&#227;o capazes de fornecer novos e valiosos <span class="elsevierStyleItalic">insights</span> sobre a estrutura atual da popula&#231;&#227;o brasileira&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Perspectivas futuras de an&#225;lises de ancestralidade das amostras sangu&#237;neas de nosso estudo poder&#227;o permitir um melhor esclarecimento acerca da associa&#231;&#227;o entre a filagrina&#160;2 e DA&#44; visto que a preval&#234;ncia das muta&#231;&#245;es do gene da filagrina apresenta diferen&#231;as &#233;tnicas tanto na popula&#231;&#227;o geral quanto em indiv&#237;duos portadores de DA&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">O pequeno tamanho amostral pode ter limitado a signific&#226;ncia de nossos resultados e talvez uma maior amostra e&#47;ou o estudo de ancestralidade poder&#225; contribuir para o esclarecimento entre indiv&#237;duos com DA e os polimorfismo da filagrina&#160;2&#46; A feitura do estudo prote&#244;mico da filagrina&#160;2&#44; j&#225; que diferen&#231;as estruturais podem se dever a controles p&#243;s&#8208;transcricionais&#44; tamb&#233;m contribuiria para uma melhor avalia&#231;&#227;o da filagrina&#160;2&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">At&#233; o momento&#44; n&#227;o h&#225; estudos de polimorfismos do gene da filagrina&#160;2 e DA na Am&#233;rica Latina&#44; o que refor&#231;ando a relev&#226;ncia de nosso estudo e o ineditismo dessa iniciativa no Brasil&#46; Al&#233;m disso&#44; este &#233; o primeiro estudo em n&#237;vel mundial que usa um grupo controle para avaliar altera&#231;&#245;es no gene da filagrina&#160;2&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclus&#227;o</span><p id="par0185" class="elsevierStylePara elsevierViewall">Muito pouco se sabe sobre o perfil de polimorfismos de filagrinas&#160;2 associados &#224; DA na altamente miscigenada popula&#231;&#227;o brasileira&#46; Os resultados deste trabalho podem ser um consider&#225;vel incentivo &#224;s pesquisas sobre polimorfismos e DA no pa&#237;s&#44; colaborar para uma melhor compreens&#227;o&#44; n&#227;o apenas de formas de tratamento da doen&#231;a&#44; mas tamb&#233;m do perfil gen&#233;tico da popula&#231;&#227;o&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Quanto ao polimorfismo rs16833974&#44; foram encontradas diferen&#231;as estatisticamente significantes em rela&#231;&#227;o &#224; vari&#225;vel etnia&#46; Quanto mais escura a cor da pele&#44; maior a chance de ocorrer o polimorfismo&#44; valor de p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;031&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Suporte financeiro</span><p id="par0200" class="elsevierStylePara elsevierViewall">Fundo de Apoio &#224; Dermatologia &#40;Funaderm&#41;&#44; da Sociedade Brasileira de Dermatologia&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Contribui&#231;&#227;o dos autores</span><p id="par0210" class="elsevierStylePara elsevierViewall">Amanda Hertz&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#59; revis&#227;o cr&#237;tica da literatura&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Luna Azulay&#8208;Abulafia&#58; Participa&#231;&#227;o efetiva na orienta&#231;&#227;o da pesquisa&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Adriana Paulino do Nascimento&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Cintya Yumi Ohara&#58; Concep&#231;&#227;o e planejamento do estudo&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Fabio Chigres Kuschnir&#58; Revis&#227;o cr&#237;tica da literatura&#59; revis&#227;o cr&#237;tica do manuscrito&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Lu&#237;s Cristov&#227;o Porto&#58; Concep&#231;&#227;o e planejamento do estudo&#59; obten&#231;&#227;o&#44; an&#225;lise e interpreta&#231;&#227;o dos dados&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflitos de interesse</span><p id="par0245" class="elsevierStylePara elsevierViewall">Nenhum&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Polimorfismos do gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;16899374&#41; est&#227;o associados com dermatite at&#243;pica persistente em pacientes negros&#46; A filagrina&#160;2 &#233; uma prote&#237;na com fun&#231;&#227;o semelhante &#224; filagrina e tamb&#233;m codificada no complexo de diferencia&#231;&#227;o da epiderme no cromossomo 1q21&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar os polimorfismos no gene da filagrina&#160;2 &#40;rs&#160;12568784 e rs&#160;16899374&#41; em crian&#231;as e adultos com dermatite at&#243;pica e verificar a associa&#231;&#227;o desses com a gravidade do quadro cl&#237;nico&#44; presen&#231;a de outras doen&#231;as al&#233;rgicas e fatores sociodemogr&#225;ficos&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">O estudo foi feito com pacientes do ambulat&#243;rio de dermatite at&#243;pica e grupo controle&#46; Foram usados question&#225;rios para avaliar etnia&#44; sexo&#44; faixa et&#225;ria&#44; hist&#243;rico familiar&#44; <span class="elsevierStyleItalic">Scoring</span><span class="elsevierStyleItalic">Atopic Dermatitis</span> &#40;SCORAD&#41;&#44; entre outros par&#226;metros&#46; A genotipagem do gene da filagrina&#160;2 foi feita atrav&#233;s de rea&#231;&#227;o em cadeia da polimerase em tempo real&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram avaliados&#160;48&#160;pacientes e 83&#160;controles&#46; N&#227;o foi encontrada uma correla&#231;&#227;o entre as vari&#225;veis estudadas dos pacientes com dermatite at&#243;pica e os polimorfismos&#46; Tamb&#233;m n&#227;o houve diferen&#231;a significativa entre a preval&#234;ncia dos polimorfismos nos pacientes e no grupo controle p&#160;&#62;&#160;0&#44;05&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limita&#231;&#245;es do estudo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O uso exclusivo de informa&#231;&#245;es da etnia autodeclarada e o n&#250;mero da amostra&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Os resultados deste trabalho podem ser um incentivo para o estudo de polimorfismos na dermatite at&#243;pica&#44; considerando&#8208;se a caracter&#237;stica multi&#233;tnica da popula&#231;&#227;o brasileira&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclus&#227;o</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Este &#233; um trabalho in&#233;dito no Brasil e o primeiro estudo no mundo a ter um grupo controle para avaliar altera&#231;&#245;es no gene da filagrina&#160;2&#46;</p></span>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Etnia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Brancos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pardos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pretos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infanto &#40;0&#8211;2 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#8211;30 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crian&#231;as &#40;3&#8211;9 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#8211;45 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adolescentes &#40;10&#8211;19 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 45 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  """
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                  \t\t\t\t" scope="col">Vari&#225;veis sociodemogr&#225;ficas&nbsp;\t\t\t\t\t\t\n
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2296272.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t" scope="col">Vari&#225;veis sociodemogr&#225;ficas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Polimorfismo rs12568784</th></tr><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Moderado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">HF Atopia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="8" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Brancos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pardos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pretos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Vari&#225;veis estudadas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Moderado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Etnia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Brancos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;38&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pardos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pretos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o identificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">100&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">29&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">57&#37;&nbsp;\t\t\t\t\t\t\n
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Article information
ISSN: 26662752
Original language: Portuguese
DOI:10.1016/j.abdp.2019.07.002
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